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Conserved domains on  [gi|2368637465|emb|CAI5246045|]
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ADM_HP2_G0007990.mRNA.1.CDS.1 [Saccharomyces cerevisiae]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Rad21_Rec8_M_ScScc1p-like cd21791
Middle HEAT-repeat binding domain found in Saccharomyces cerevisiae sister chromatid cohesion ...
 315-394 4.52e-27

Middle HEAT-repeat binding domain found in Saccharomyces cerevisiae sister chromatid cohesion protein 1 (ScScc1p) and similar proteins; ScScc1p, also called Mcd1, or Rhc21, or Pds3, is a cleavable component of the cohesin complex involved in chromosome cohesion during the cell cycle. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At the metaphase-anaphase transition, ScScc1p is cleaved by ESP1 and dissociates from chromatin, allowing sister chromatids to segregate. This model corresponds to HEAT-repeat binding domain of ScScc1p in the middle region, which consists of short helices and two long extended segments. It is responsible for the binding of the budding yeast cohesin HEAT-repeat subunit Scc3. The Scc3-Scc1 subcomplex engages double-stranded DNA through a conserved, positively charged surface, and plays a central role in the recruitment of cohesin complexes to chromosomes and therefore for cohesin to faithfully execute its functions during cell division.


:

Pssm-ID: 439293  Cd Length: 82  Bit Score: 104.32  E-value: 4.52e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2368637465 315 RRNSKLLNTKSIQIDEETENSESI----ASSNTYKEERSNNlltpQPTNFTTKRLWSEITESMSYLPDSILKNFLSYESL 390
Cdd:cd21791     3 RKNSALSNTKKIQVDDETELSDEEvketESPPTNSDESSNN----QEPKLTKKRLWSEIAESMDYLPQSIVENLLSYQSL 78


                  ....
gi 2368637465 391 KKRK 394
Cdd:cd21791    79 KKQK 82
Rad21_Rec8_N pfam04825
N terminus of Rad21 / Rec8 like protein; This family represents a conserved N-terminal region ...
 17-108 6.70e-22

N terminus of Rad21 / Rec8 like protein; This family represents a conserved N-terminal region found in eukaryotic cohesins of the Rad21, Rec8 and Scc1 families. Members of this family mediate sister chromatid cohesion during mitosis and meiosis, as part of the cohesin complex. Cohesion is necessary for homologous recombination (including double-strand break repair) and correct chromatid segregation. These proteins may also be involved in chromosome condensation. Dissociation at the metaphase to anaphase transition causes loss of cohesion and chromatid segregation.


:

Pssm-ID: 461446  Cd Length: 104  Bit Score: 90.69  E-value: 6.70e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2368637465  17 NKGPLAQIWLASNM-SNIPRGSVIQTHIAESAKEIAKASgcddesgdnEYITLRTSGELLQGIVRVYSKQATFLLTDIKD 95
Cdd:pfam04825  10 KKGPLATVWLAATLgKKLSKKQILEVDIPKACETIINPE---------APLALRLSGQLLLGVVRIYSRKAKYLLDDCNE 80

                          90
                  ....*....|...
gi 2368637465  96 TLTKISMLFKTSQ 108
Cdd:pfam04825  81 ALVKIKKAFRPGQ 93
Rad21_Rec8 pfam04824
Conserved region of Rad21 / Rec8 like protein; This family represents a conserved region found ...
 505-559 1.31e-16

Conserved region of Rad21 / Rec8 like protein; This family represents a conserved region found in eukaryotic cohesins of the Rad21, Rec8 and Scc1 families. Members of this family mediate sister chromatid cohesion during mitosis and meiosis, as part of the cohesin complex. Cohesion is necessary for homologous recombination (including double-strand break repair) and correct chromatid segregation. These proteins may also be involved in chromosome condensation. Dissociation at the metaphase to anaphase transition causes loss of cohesion and chromatid segregation.


:

Pssm-ID: 335912  Cd Length: 55  Bit Score: 73.91  E-value: 1.31e-16
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2368637465 505 TDVLKSQANTEPENITKREASRGFFDILSLATEGCIGLSQTEAFGNIKIDAKPAL 559
Cdd:pfam04824   1 TEGEKDSLSLLPAGKTRKEAARLFYELLVLATKGAIKVKQEEPYGDILITPGPKF 55
 
Name Accession Description Interval E-value
Rad21_Rec8_M_ScScc1p-like cd21791
Middle HEAT-repeat binding domain found in Saccharomyces cerevisiae sister chromatid cohesion ...
 315-394 4.52e-27

Middle HEAT-repeat binding domain found in Saccharomyces cerevisiae sister chromatid cohesion protein 1 (ScScc1p) and similar proteins; ScScc1p, also called Mcd1, or Rhc21, or Pds3, is a cleavable component of the cohesin complex involved in chromosome cohesion during the cell cycle. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At the metaphase-anaphase transition, ScScc1p is cleaved by ESP1 and dissociates from chromatin, allowing sister chromatids to segregate. This model corresponds to HEAT-repeat binding domain of ScScc1p in the middle region, which consists of short helices and two long extended segments. It is responsible for the binding of the budding yeast cohesin HEAT-repeat subunit Scc3. The Scc3-Scc1 subcomplex engages double-stranded DNA through a conserved, positively charged surface, and plays a central role in the recruitment of cohesin complexes to chromosomes and therefore for cohesin to faithfully execute its functions during cell division.


Pssm-ID: 439293  Cd Length: 82  Bit Score: 104.32  E-value: 4.52e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2368637465 315 RRNSKLLNTKSIQIDEETENSESI----ASSNTYKEERSNNlltpQPTNFTTKRLWSEITESMSYLPDSILKNFLSYESL 390
Cdd:cd21791     3 RKNSALSNTKKIQVDDETELSDEEvketESPPTNSDESSNN----QEPKLTKKRLWSEIAESMDYLPQSIVENLLSYQSL 78


                  ....
gi 2368637465 391 KKRK 394
Cdd:cd21791    79 KKQK 82
Rad21_Rec8_N pfam04825
N terminus of Rad21 / Rec8 like protein; This family represents a conserved N-terminal region ...
 17-108 6.70e-22

N terminus of Rad21 / Rec8 like protein; This family represents a conserved N-terminal region found in eukaryotic cohesins of the Rad21, Rec8 and Scc1 families. Members of this family mediate sister chromatid cohesion during mitosis and meiosis, as part of the cohesin complex. Cohesion is necessary for homologous recombination (including double-strand break repair) and correct chromatid segregation. These proteins may also be involved in chromosome condensation. Dissociation at the metaphase to anaphase transition causes loss of cohesion and chromatid segregation.


Pssm-ID: 461446  Cd Length: 104  Bit Score: 90.69  E-value: 6.70e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2368637465  17 NKGPLAQIWLASNM-SNIPRGSVIQTHIAESAKEIAKASgcddesgdnEYITLRTSGELLQGIVRVYSKQATFLLTDIKD 95
Cdd:pfam04825  10 KKGPLATVWLAATLgKKLSKKQILEVDIPKACETIINPE---------APLALRLSGQLLLGVVRIYSRKAKYLLDDCNE 80

                          90
                  ....*....|...
gi 2368637465  96 TLTKISMLFKTSQ 108
Cdd:pfam04825  81 ALVKIKKAFRPGQ 93
Rad21_Rec8 pfam04824
Conserved region of Rad21 / Rec8 like protein; This family represents a conserved region found ...
 505-559 1.31e-16

Conserved region of Rad21 / Rec8 like protein; This family represents a conserved region found in eukaryotic cohesins of the Rad21, Rec8 and Scc1 families. Members of this family mediate sister chromatid cohesion during mitosis and meiosis, as part of the cohesin complex. Cohesion is necessary for homologous recombination (including double-strand break repair) and correct chromatid segregation. These proteins may also be involved in chromosome condensation. Dissociation at the metaphase to anaphase transition causes loss of cohesion and chromatid segregation.


Pssm-ID: 335912  Cd Length: 55  Bit Score: 73.91  E-value: 1.31e-16
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2368637465 505 TDVLKSQANTEPENITKREASRGFFDILSLATEGCIGLSQTEAFGNIKIDAKPAL 559
Cdd:pfam04824   1 TEGEKDSLSLLPAGKTRKEAARLFYELLVLATKGAIKVKQEEPYGDILITPGPKF 55
 
Name Accession Description Interval E-value
Rad21_Rec8_M_ScScc1p-like cd21791
Middle HEAT-repeat binding domain found in Saccharomyces cerevisiae sister chromatid cohesion ...
 315-394 4.52e-27

Middle HEAT-repeat binding domain found in Saccharomyces cerevisiae sister chromatid cohesion protein 1 (ScScc1p) and similar proteins; ScScc1p, also called Mcd1, or Rhc21, or Pds3, is a cleavable component of the cohesin complex involved in chromosome cohesion during the cell cycle. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At the metaphase-anaphase transition, ScScc1p is cleaved by ESP1 and dissociates from chromatin, allowing sister chromatids to segregate. This model corresponds to HEAT-repeat binding domain of ScScc1p in the middle region, which consists of short helices and two long extended segments. It is responsible for the binding of the budding yeast cohesin HEAT-repeat subunit Scc3. The Scc3-Scc1 subcomplex engages double-stranded DNA through a conserved, positively charged surface, and plays a central role in the recruitment of cohesin complexes to chromosomes and therefore for cohesin to faithfully execute its functions during cell division.


Pssm-ID: 439293  Cd Length: 82  Bit Score: 104.32  E-value: 4.52e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2368637465 315 RRNSKLLNTKSIQIDEETENSESI----ASSNTYKEERSNNlltpQPTNFTTKRLWSEITESMSYLPDSILKNFLSYESL 390
Cdd:cd21791     3 RKNSALSNTKKIQVDDETELSDEEvketESPPTNSDESSNN----QEPKLTKKRLWSEIAESMDYLPQSIVENLLSYQSL 78


                  ....
gi 2368637465 391 KKRK 394
Cdd:cd21791    79 KKQK 82
Rad21_Rec8_N pfam04825
N terminus of Rad21 / Rec8 like protein; This family represents a conserved N-terminal region ...
 17-108 6.70e-22

N terminus of Rad21 / Rec8 like protein; This family represents a conserved N-terminal region found in eukaryotic cohesins of the Rad21, Rec8 and Scc1 families. Members of this family mediate sister chromatid cohesion during mitosis and meiosis, as part of the cohesin complex. Cohesion is necessary for homologous recombination (including double-strand break repair) and correct chromatid segregation. These proteins may also be involved in chromosome condensation. Dissociation at the metaphase to anaphase transition causes loss of cohesion and chromatid segregation.


Pssm-ID: 461446  Cd Length: 104  Bit Score: 90.69  E-value: 6.70e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2368637465  17 NKGPLAQIWLASNM-SNIPRGSVIQTHIAESAKEIAKASgcddesgdnEYITLRTSGELLQGIVRVYSKQATFLLTDIKD 95
Cdd:pfam04825  10 KKGPLATVWLAATLgKKLSKKQILEVDIPKACETIINPE---------APLALRLSGQLLLGVVRIYSRKAKYLLDDCNE 80

                          90
                  ....*....|...
gi 2368637465  96 TLTKISMLFKTSQ 108
Cdd:pfam04825  81 ALVKIKKAFRPGQ 93
Rad21_Rec8 pfam04824
Conserved region of Rad21 / Rec8 like protein; This family represents a conserved region found ...
 505-559 1.31e-16

Conserved region of Rad21 / Rec8 like protein; This family represents a conserved region found in eukaryotic cohesins of the Rad21, Rec8 and Scc1 families. Members of this family mediate sister chromatid cohesion during mitosis and meiosis, as part of the cohesin complex. Cohesion is necessary for homologous recombination (including double-strand break repair) and correct chromatid segregation. These proteins may also be involved in chromosome condensation. Dissociation at the metaphase to anaphase transition causes loss of cohesion and chromatid segregation.


Pssm-ID: 335912  Cd Length: 55  Bit Score: 73.91  E-value: 1.31e-16
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2368637465 505 TDVLKSQANTEPENITKREASRGFFDILSLATEGCIGLSQTEAFGNIKIDAKPAL 559
Cdd:pfam04824   1 TEGEKDSLSLLPAGKTRKEAARLFYELLVLATKGAIKVKQEEPYGDILITPGPKF 55
Rad21_Rec8_M cd21747
Middle HEAT-repeat binding domain of Rad21/Rec8-like proteins; This family includes eukaryotic ...
 314-373 9.49e-07

Middle HEAT-repeat binding domain of Rad21/Rec8-like proteins; This family includes eukaryotic cohesins of the Rad21, Rec8, and Scc1 subfamilies. They mediate sister chromatid cohesion during mitosis and meiosis, as part of the cohesin complex. Cohesion is necessary for homologous recombination (including double-strand break repair) and correct chromatid segregation. These proteins may also be involved in chromosome condensation. Dissociation at the metaphase to anaphase transition causes loss of cohesion and chromatid segregation. This model corresponds to a conserved middle/central region of family members, consisting of short helices and two extended segments, which functions in binding to HEAT-repeat containing cohesin subunits. For example, human Scc1 homolog (NXP-1) binds to either SA1 or SA2, two homologous HEAT-containing proteins; the SA-Scc1 heterodimer mediates the binding between cohesin and its regulators, including Scc2-Scc4, Pds5, Wapl, and Sgo1.


Pssm-ID: 439289 [Multi-domain]  Cd Length: 79  Bit Score: 46.69  E-value: 9.49e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2368637465 314 TRRNSKLLNTKSIQIDEETENSESIASSNTYKEERSNNLLT--PQPTNFTTKRLWSEITESM 373
Cdd:cd21747     2 RRRKRKLLIDEVTELSTEQMRSQLQDTSDIVRSRDLNPPTPvrPLRKASGTDSLFSLNPLSG 63
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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