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Conserved domains on  [gi|83999032|emb|CAI77114|]
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drs protein [Drosophila melanogaster]

Protein Classification

gamma-thionin family protein( domain architecture ID 10447803)

gamma-thionin family protein adopting the "knottin" fold, a stable cysteine-rich scaffold, in which one disulfide bridge crosses the macrocycle made by two other disulfide bridges and the connecting backbone segments, found in plant lectins/antimicrobial peptides, plant proteinase/amylase inhibitors, plant gamma-thionins, and arthropod defensins

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Gamma-thionin pfam00304
Gamma-thionin family;
27-69 1.31e-09

Gamma-thionin family;


:

Pssm-ID: 395240  Cd Length: 44  Bit Score: 48.04  E-value: 1.31e-09
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 83999032   27 DCLSGRYKGPCAVWDNetCRRVCKEEGRSSGHCS-PSLKCWCEG 69
Cdd:pfam00304  1 ESKSGRFKGPCLSDSN--CANVCINEGFGGGHCSgPRRRCFCTR 42
 
Name Accession Description Interval E-value
Gamma-thionin pfam00304
Gamma-thionin family;
27-69 1.31e-09

Gamma-thionin family;


Pssm-ID: 395240  Cd Length: 44  Bit Score: 48.04  E-value: 1.31e-09
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 83999032   27 DCLSGRYKGPCAVWDNetCRRVCKEEGRSSGHCS-PSLKCWCEG 69
Cdd:pfam00304  1 ESKSGRFKGPCLSDSN--CANVCINEGFGGGHCSgPRRRCFCTR 42
neurotoxins_LC_scorpion cd23106
long-chain neurotoxins from scorpions; Scorpion venoms contain groups of neurotoxins active ...
39-69 2.75e-04

long-chain neurotoxins from scorpions; Scorpion venoms contain groups of neurotoxins active specifically on mammals or insects. These peptide toxins can be classified into two main categories based on their molecular sizes and pharmacological actions. Short-chain toxins, composed of 30-40 amino acid residues with 3 or 4 disulfide bonds, affect mainly potassium or chloride channels, while long-chain toxins, composed of 60-70 amino acid residues with 4 disulfide bonds, affect mainly sodium channels and can be divided into two groups, the alpha and beta toxins. The alpha toxins bind in a voltage-dependent manner and modulate the sodium current inactivation stage, whereas binding of beta toxins is voltage-independent and interferes with the sodium current activation stage. The beta toxin class includes the groups of excitatory and depressant toxins, which differ in their mode of action and are highly specific against insects. They can selectively bind to the corresponding channels on the membrane of excitable cells, thus impairing the initial rapid depolarization phase of the action potential in nerve and muscle, resulting in neurotoxicity. This family contains the long-chain alpha and beta toxins from scorpion venom.


Pssm-ID: 467870  Cd Length: 60  Bit Score: 34.91  E-value: 2.75e-04
                       10        20        30
               ....*....|....*....|....*....|.
gi 83999032 39 VWDNETCRRVCKEEGRSSGHCSPSLKCWCEG 69
Cdd:cd23106 15 LIENEYCNKECKKKGGSSGYCYWWLACWCEG 45
Knot1 smart00505
Knottins; Knottins, representing plant lectins/antimicrobial peptides, plant proteinase ...
29-69 3.30e-04

Knottins; Knottins, representing plant lectins/antimicrobial peptides, plant proteinase/amylase inhibitors, plant gamma-thionins and arthropod defensins.


Pssm-ID: 214700  Cd Length: 45  Bit Score: 34.37  E-value: 3.30e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 83999032    29 LSGRYKGPCAVWDNEtCRRVCKEEGRSSGHCSP-SLKCWCEG 69
Cdd:smart00505  5 YSVTFSGNCKSSCAL-CAKLCKKKGAKGGYCRGtTRRCFCYK 45
 
Name Accession Description Interval E-value
Gamma-thionin pfam00304
Gamma-thionin family;
27-69 1.31e-09

Gamma-thionin family;


Pssm-ID: 395240  Cd Length: 44  Bit Score: 48.04  E-value: 1.31e-09
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 83999032   27 DCLSGRYKGPCAVWDNetCRRVCKEEGRSSGHCS-PSLKCWCEG 69
Cdd:pfam00304  1 ESKSGRFKGPCLSDSN--CANVCINEGFGGGHCSgPRRRCFCTR 42
neurotoxins_LC_scorpion cd23106
long-chain neurotoxins from scorpions; Scorpion venoms contain groups of neurotoxins active ...
39-69 2.75e-04

long-chain neurotoxins from scorpions; Scorpion venoms contain groups of neurotoxins active specifically on mammals or insects. These peptide toxins can be classified into two main categories based on their molecular sizes and pharmacological actions. Short-chain toxins, composed of 30-40 amino acid residues with 3 or 4 disulfide bonds, affect mainly potassium or chloride channels, while long-chain toxins, composed of 60-70 amino acid residues with 4 disulfide bonds, affect mainly sodium channels and can be divided into two groups, the alpha and beta toxins. The alpha toxins bind in a voltage-dependent manner and modulate the sodium current inactivation stage, whereas binding of beta toxins is voltage-independent and interferes with the sodium current activation stage. The beta toxin class includes the groups of excitatory and depressant toxins, which differ in their mode of action and are highly specific against insects. They can selectively bind to the corresponding channels on the membrane of excitable cells, thus impairing the initial rapid depolarization phase of the action potential in nerve and muscle, resulting in neurotoxicity. This family contains the long-chain alpha and beta toxins from scorpion venom.


Pssm-ID: 467870  Cd Length: 60  Bit Score: 34.91  E-value: 2.75e-04
                       10        20        30
               ....*....|....*....|....*....|.
gi 83999032 39 VWDNETCRRVCKEEGRSSGHCSPSLKCWCEG 69
Cdd:cd23106 15 LIENEYCNKECKKKGGSSGYCYWWLACWCEG 45
Knot1 smart00505
Knottins; Knottins, representing plant lectins/antimicrobial peptides, plant proteinase ...
29-69 3.30e-04

Knottins; Knottins, representing plant lectins/antimicrobial peptides, plant proteinase/amylase inhibitors, plant gamma-thionins and arthropod defensins.


Pssm-ID: 214700  Cd Length: 45  Bit Score: 34.37  E-value: 3.30e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 83999032    29 LSGRYKGPCAVWDNEtCRRVCKEEGRSSGHCSP-SLKCWCEG 69
Cdd:smart00505  5 YSVTFSGNCKSSCAL-CAKLCKKKGAKGGYCRGtTRRCFCYK 45
Knot1 cd00107
The "knottin" fold is stable cysteine-rich scaffold, in which one disulfide bridge crosses the ...
35-68 5.12e-03

The "knottin" fold is stable cysteine-rich scaffold, in which one disulfide bridge crosses the macrocycle made by two other disulfide bridges and the connecting backbone segments. Members include plant lectins/antimicrobial peptides, plant proteinase/amylase inhibitors, plant gamma-thionins, and arthropod defensins.


Pssm-ID: 238055  Cd Length: 33  Bit Score: 31.17  E-value: 5.12e-03
                       10        20        30
               ....*....|....*....|....*....|....*
gi 83999032 35 GPCAVWDNetCRRVCKEEGRSSGHCSP-SLKCWCE 68
Cdd:cd00107  1 GTCFSDSY--CDKECKKKGASGGYCYGqGLACWCY 33
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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