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Conserved domains on  [gi|2474877695|emb|CAI8284922|]
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MAG: Phosphoserine aminotransferase [uncultured Bacteroidetes bacterium]

Protein Classification

3-phosphoserine/phosphohydroxythreonine transaminase( domain architecture ID 10012345)

3-phosphoserine/phosphohydroxythreonine transaminase catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
SerC COG1932
Phosphoserine aminotransferase [Coenzyme transport and metabolism, Amino acid transport and ...
1-353 0e+00

Phosphoserine aminotransferase [Coenzyme transport and metabolism, Amino acid transport and metabolism]; Phosphoserine aminotransferase is part of the Pathway/BioSystem: Serine biosynthesis


:

Pssm-ID: 441535  Cd Length: 358  Bit Score: 541.58  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2474877695   1 MRLHNFSAGPSILPKEVMHQAAEAVKELDGSKLSLIEISHRSKAFIDIMDEACERALRLTGLeGKGYKAIFLQGGASLQF 80
Cdd:COG1932     1 MRVYNFSAGPAKLPEEVLEQAQAELLDWNGSGMSVMEMSHRSKPFKAIVEEAEADLRELLGI-PDGYEVLFLQGGATAQF 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2474877695  81 LMAAYNLLEN--KAGYLNTGTWSDKAIKEAKLFGEVIEIASSKDQNYNHIPK--DYSIPSGLDYLHLTTNNTIFGTQFKS 156
Cdd:COG1932    80 AMVPMNLLRGgkKADYLVTGEWSKKAIKEAKKYGEVNVVASSEDDNFGYIPKpeEWQLSPDADYVHYTSNETITGVEFHE 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2474877695 157 IPET-DAPLVADMSSDIFSRTFDYSKFDLFYAGAQKNMGPAGTTLVIVKESLLGKVSRAIPSMMSYEVHASKDSMFNTPP 235
Cdd:COG1932   160 LPDVgDVPLVADMSSDILSRPVDVSKFGLIYAGAQKNIGPAGLTVVIVRPDLLGRAERAIPSMLDYKTHADNDSMYNTPP 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2474877695 236 VFAVYTSMLNMRWIESQGGIRSLGDKNSVKSTLLYGEIDRNSLFEGFAAKEDRSDMNATFNLKDTAYTEAFDSLCQTAGI 315
Cdd:COG1932   240 TFAIYLAGLVLKWLKEQGGLAAMEKRNAEKAALLYDWIDASDFYTNPVDPEDRSRMNVTFDLADEELDAAFLAEAKAAGL 319
                         330       340       350
                  ....*....|....*....|....*....|....*...
gi 2474877695 316 SGLKGHRSVGGYRASMYNAMSIESVEILVDCMQILEKK 353
Cdd:COG1932   320 VGLKGHRSVGGMRASIYNAMPLEGVEALVDFMDEFERR 357
 
Name Accession Description Interval E-value
SerC COG1932
Phosphoserine aminotransferase [Coenzyme transport and metabolism, Amino acid transport and ...
1-353 0e+00

Phosphoserine aminotransferase [Coenzyme transport and metabolism, Amino acid transport and metabolism]; Phosphoserine aminotransferase is part of the Pathway/BioSystem: Serine biosynthesis


Pssm-ID: 441535  Cd Length: 358  Bit Score: 541.58  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2474877695   1 MRLHNFSAGPSILPKEVMHQAAEAVKELDGSKLSLIEISHRSKAFIDIMDEACERALRLTGLeGKGYKAIFLQGGASLQF 80
Cdd:COG1932     1 MRVYNFSAGPAKLPEEVLEQAQAELLDWNGSGMSVMEMSHRSKPFKAIVEEAEADLRELLGI-PDGYEVLFLQGGATAQF 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2474877695  81 LMAAYNLLEN--KAGYLNTGTWSDKAIKEAKLFGEVIEIASSKDQNYNHIPK--DYSIPSGLDYLHLTTNNTIFGTQFKS 156
Cdd:COG1932    80 AMVPMNLLRGgkKADYLVTGEWSKKAIKEAKKYGEVNVVASSEDDNFGYIPKpeEWQLSPDADYVHYTSNETITGVEFHE 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2474877695 157 IPET-DAPLVADMSSDIFSRTFDYSKFDLFYAGAQKNMGPAGTTLVIVKESLLGKVSRAIPSMMSYEVHASKDSMFNTPP 235
Cdd:COG1932   160 LPDVgDVPLVADMSSDILSRPVDVSKFGLIYAGAQKNIGPAGLTVVIVRPDLLGRAERAIPSMLDYKTHADNDSMYNTPP 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2474877695 236 VFAVYTSMLNMRWIESQGGIRSLGDKNSVKSTLLYGEIDRNSLFEGFAAKEDRSDMNATFNLKDTAYTEAFDSLCQTAGI 315
Cdd:COG1932   240 TFAIYLAGLVLKWLKEQGGLAAMEKRNAEKAALLYDWIDASDFYTNPVDPEDRSRMNVTFDLADEELDAAFLAEAKAAGL 319
                         330       340       350
                  ....*....|....*....|....*....|....*...
gi 2474877695 316 SGLKGHRSVGGYRASMYNAMSIESVEILVDCMQILEKK 353
Cdd:COG1932   320 VGLKGHRSVGGMRASIYNAMPLEGVEALVDFMDEFERR 357
PRK05355 PRK05355
3-phosphoserine/phosphohydroxythreonine transaminase;
1-353 0e+00

3-phosphoserine/phosphohydroxythreonine transaminase;


Pssm-ID: 235428  Cd Length: 360  Bit Score: 540.84  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2474877695   1 MRLHNFSAGPSILPKEVMHQAAEAVKELDGSKLSLIEISHRSKAFIDIMDEACERALRLTGLeGKGYKAIFLQGGASLQF 80
Cdd:PRK05355    2 MRVYNFSAGPAMLPEEVLEQAQQELLDWNGSGMSVMEISHRSKEFEAVAEEAEADLRELLNI-PDNYKVLFLQGGASLQF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2474877695  81 LMAAYNLLEN--KAGYLNTGTWSDKAIKEAKLFGEVIEIASSKDQNYNHIPK--DYSIPSGLDYLHLTTNNTIFGTQFKS 156
Cdd:PRK05355   81 AMVPMNLLGGgkKADYVDTGSWSKKAIKEAKKYGEVNVAASSEDDGFTYIPPldEWQLSDDAAYVHYTSNETIDGTEFHE 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2474877695 157 IPET-DAPLVADMSSDIFSRTFDYSKFDLFYAGAQKNMGPAGTTLVIVKESLLGKVSRAIPSMMSYEVHASKDSMFNTPP 235
Cdd:PRK05355  161 LPDTgDVPLVADMSSDILSRPIDVSKFGLIYAGAQKNIGPAGLTIVIVREDLLGRALPSIPSMLDYKTHADNDSMYNTPP 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2474877695 236 VFAVYTSMLNMRWIESQGGIRSLGDKNSVKSTLLYGEIDRNSLFEGFAAKEDRSDMNATFNLKDTAYTEAFDSLCQTAGI 315
Cdd:PRK05355  241 TFAIYLAGLVFKWLKEQGGVAAMEKRNQEKAALLYDAIDSSDFYRNPVAPEDRSRMNVPFTLADEELDKKFLAEAKAAGL 320
                         330       340       350
                  ....*....|....*....|....*....|....*...
gi 2474877695 316 SGLKGHRSVGGYRASMYNAMSIESVEILVDCMQILEKK 353
Cdd:PRK05355  321 VGLKGHRSVGGMRASIYNAMPLEGVQALVDFMKEFERR 358
PSAT_like cd00611
Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP) ...
4-352 1.07e-151

Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as a dimer and catalyzes the conversion of phosphohydroxypyruvate to phosphoserine.


Pssm-ID: 99736 [Multi-domain]  Cd Length: 355  Bit Score: 430.95  E-value: 1.07e-151
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2474877695   4 HNFSAGPSILPKEVMHQAAEAVKELDGSKLSLIEISHRSKAFIDIMDEACERALRLTGLEgKGYKAIFLQGGASLQFLMA 83
Cdd:cd00611     1 INFSAGPAALPEEVLEQAQKELLDFNGLGMSVMEMSHRSKDFEAIVNEAESDLRELLNIP-DNYKVLFLQGGATGQFAAV 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2474877695  84 AYNLL--ENKAGYLNTGTWSDKAIKEAKLFGEVIEIASSKD-QNYNHIPKDYSIP--SGLDYLHLTTNNTIFGTQFKSIP 158
Cdd:cd00611    80 PLNLLgdKGTADYVVTGAWSAKAAKEAKRYGGVVVIVAAKEeGKYTKIPDVETWDlaPDAAYVHYCSNETIHGVEFDEVP 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2474877695 159 ET-DAPLVADMSSDIFSRTFDYSKFDLFYAGAQKNMGPAGTTLVIVKESLLGKVSRAIPSMMSYEVHASKDSMFNTPPVF 237
Cdd:cd00611   160 DTgGVPLVADMSSNILSRPIDVSKFGVIYAGAQKNLGPAGVTVVIVRKDLLGKARKITPSMLNYKTHADNNSLYNTPPTF 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2474877695 238 AVYTSMLNMRWIESQGGIRSLGDKNSVKSTLLYGEIDRNS-LFEGFAAKEDRSDMNATFNLKDTAYTEAFDSLCQTAGIS 316
Cdd:cd00611   240 AIYMMGLVLKWLKEQGGVEAMEKRNRQKAQLLYDTIDNSNgFYRGPVDKRARSRMNVPFRLGKEELEKEFLKEAEAAGMI 319
                         330       340       350
                  ....*....|....*....|....*....|....*.
gi 2474877695 317 GLKGHRSVGGYRASMYNAMSIESVEILVDCMQILEK 352
Cdd:cd00611   320 GLKGHRSVGGIRASIYNALSLEGVQALADFMKEFQK 355
serC_1 TIGR01364
phosphoserine aminotransferase; This model represents the common form of the phosphoserine ...
11-353 3.22e-141

phosphoserine aminotransferase; This model represents the common form of the phosphoserine aminotransferase SerC. The phosphoserine aminotransferase of the archaeon Methanosarcina barkeri and putative phosphoserine aminotransferase of Mycobacterium tuberculosis are represented by separate models. All are members of the class V aminotransferases (pfam00266). [Amino acid biosynthesis, Serine family]


Pssm-ID: 130431  Cd Length: 349  Bit Score: 403.97  E-value: 3.22e-141
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2474877695  11 SILPKEVMHQAAEAVKELDGSKLSLIEISHRSKAFIDIMDEAcERALR-LTGLEgKGYKAIFLQGGASLQFLMAAYNLLE 89
Cdd:TIGR01364   1 AALPEEVLEQAQKELLNFNGTGMSVMEISHRSKEFEAVANEA-ESDLReLLNIP-DNYEVLFLQGGATGQFAAVPLNLLA 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2474877695  90 N--KAGYLNTGTWSDKAIKEAKLFGEVIEIASSKDQNYNHIP--KDYSIPSGLDYLHLTTNNTIFGTQFKSIPE-TDAPL 164
Cdd:TIGR01364  79 EgkVADYIVTGAWSKKAAKEAKKYGVVNVVASGKEGNYTKIPdpSTWEISEDAAYVHYCANETIHGVEFRELPDvKNAPL 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2474877695 165 VADMSSDIFSRTFDYSKFDLFYAGAQKNMGPAGTTLVIVKESLLGKVSRAIPSMMSYEVHASKDSMFNTPPVFAVYTSML 244
Cdd:TIGR01364 159 VADMSSNILSRPIDVSKFGLIYAGAQKNIGPAGLTVVIVRKDLLGRASRITPSMLNYKIHAENDSMYNTPPTFAIYVSGL 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2474877695 245 NMRWIESQGGIRSLGDKNSVKSTLLYGEIDRNS-LFEGFAAKEDRSDMNATFNLKDTAYTEAFDSLCQTAGISGLKGHRS 323
Cdd:TIGR01364 239 VFKWLKEQGGVKAIEKRNQAKAQLLYDTIDNSNgFYRNPVDPRNRSRMNVVFTLGNEELEKRFLKEAEERGLVSLKGHRS 318
                         330       340       350
                  ....*....|....*....|....*....|
gi 2474877695 324 VGGYRASMYNAMSIESVEILVDCMQILEKK 353
Cdd:TIGR01364 319 VGGMRASIYNAMPLEGVQALVDFMKEFQKK 348
Aminotran_5 pfam00266
Aminotransferase class-V; This domain is found in amino transferases, and other enzymes ...
5-343 5.49e-30

Aminotransferase class-V; This domain is found in amino transferases, and other enzymes including cysteine desulphurase EC:4.4.1.-.


Pssm-ID: 425567 [Multi-domain]  Cd Length: 368  Bit Score: 117.73  E-value: 5.49e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2474877695   5 NFSAGPSILPKEVMHQAAEAVKELDGSKLSliEISHRSKAFIDIMDEACERALRLTGLEGKgYKAIFLQGGASlQFLMAA 84
Cdd:pfam00266   3 LDSAATTQKPQEVLDAIQEYYTDYNGNVHR--GVHTLGKEATQAYEEAREKVAEFINAPSN-DEIIFTSGTTE-AINLVA 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2474877695  85 YNLLEN-KAG----YLNTGTWSDK-AIKEAKLFG--EVIEIASSKDQNYNHIPKDYSIPSGLDYLHLTTNNTIFGTQF-- 154
Cdd:pfam00266  79 LSLGRSlKPGdeivITEMEHHANLvPWQELAKRTgaRVRVLPLDEDGLLDLDELEKLITPKTKLVAITHVSNVTGTIQpv 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2474877695 155 ----KSIPETDAPLVADMSSDIFSRTFDYSKF--DLFYAGAQKNMGPAGTTLVIVKESLLGKVS--------RAIPSmMS 220
Cdd:pfam00266 159 peigKLAHQYGALVLVDAAQAIGHRPIDVQKLgvDFLAFSGHKLYGPTGIGVLYGRRDLLEKMPpllggggmIETVS-LQ 237
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2474877695 221 YEVHASKDSMFN--TPPVFAVYTSMLNMRWIESqGGIRSLGDKNSVKSTLLYGEIDRNSLFEGFAAKEDRSDMNATFNLK 298
Cdd:pfam00266 238 ESTFADAPWKFEagTPNIAGIIGLGAALEYLSE-IGLEAIEKHEHELAQYLYERLLSLPGIRLYGPERRASIISFNFKGV 316
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2474877695 299 DTAYTEafdSLCQTAGISGLKGHRSV----------GGYRASMYNAMSIESVEIL 343
Cdd:pfam00266 317 HPHDVA---TLLDESGIAVRSGHHCAqplmvrlglgGTVRASFYIYNTQEDVDRL 368
 
Name Accession Description Interval E-value
SerC COG1932
Phosphoserine aminotransferase [Coenzyme transport and metabolism, Amino acid transport and ...
1-353 0e+00

Phosphoserine aminotransferase [Coenzyme transport and metabolism, Amino acid transport and metabolism]; Phosphoserine aminotransferase is part of the Pathway/BioSystem: Serine biosynthesis


Pssm-ID: 441535  Cd Length: 358  Bit Score: 541.58  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2474877695   1 MRLHNFSAGPSILPKEVMHQAAEAVKELDGSKLSLIEISHRSKAFIDIMDEACERALRLTGLeGKGYKAIFLQGGASLQF 80
Cdd:COG1932     1 MRVYNFSAGPAKLPEEVLEQAQAELLDWNGSGMSVMEMSHRSKPFKAIVEEAEADLRELLGI-PDGYEVLFLQGGATAQF 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2474877695  81 LMAAYNLLEN--KAGYLNTGTWSDKAIKEAKLFGEVIEIASSKDQNYNHIPK--DYSIPSGLDYLHLTTNNTIFGTQFKS 156
Cdd:COG1932    80 AMVPMNLLRGgkKADYLVTGEWSKKAIKEAKKYGEVNVVASSEDDNFGYIPKpeEWQLSPDADYVHYTSNETITGVEFHE 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2474877695 157 IPET-DAPLVADMSSDIFSRTFDYSKFDLFYAGAQKNMGPAGTTLVIVKESLLGKVSRAIPSMMSYEVHASKDSMFNTPP 235
Cdd:COG1932   160 LPDVgDVPLVADMSSDILSRPVDVSKFGLIYAGAQKNIGPAGLTVVIVRPDLLGRAERAIPSMLDYKTHADNDSMYNTPP 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2474877695 236 VFAVYTSMLNMRWIESQGGIRSLGDKNSVKSTLLYGEIDRNSLFEGFAAKEDRSDMNATFNLKDTAYTEAFDSLCQTAGI 315
Cdd:COG1932   240 TFAIYLAGLVLKWLKEQGGLAAMEKRNAEKAALLYDWIDASDFYTNPVDPEDRSRMNVTFDLADEELDAAFLAEAKAAGL 319
                         330       340       350
                  ....*....|....*....|....*....|....*...
gi 2474877695 316 SGLKGHRSVGGYRASMYNAMSIESVEILVDCMQILEKK 353
Cdd:COG1932   320 VGLKGHRSVGGMRASIYNAMPLEGVEALVDFMDEFERR 357
PRK05355 PRK05355
3-phosphoserine/phosphohydroxythreonine transaminase;
1-353 0e+00

3-phosphoserine/phosphohydroxythreonine transaminase;


Pssm-ID: 235428  Cd Length: 360  Bit Score: 540.84  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2474877695   1 MRLHNFSAGPSILPKEVMHQAAEAVKELDGSKLSLIEISHRSKAFIDIMDEACERALRLTGLeGKGYKAIFLQGGASLQF 80
Cdd:PRK05355    2 MRVYNFSAGPAMLPEEVLEQAQQELLDWNGSGMSVMEISHRSKEFEAVAEEAEADLRELLNI-PDNYKVLFLQGGASLQF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2474877695  81 LMAAYNLLEN--KAGYLNTGTWSDKAIKEAKLFGEVIEIASSKDQNYNHIPK--DYSIPSGLDYLHLTTNNTIFGTQFKS 156
Cdd:PRK05355   81 AMVPMNLLGGgkKADYVDTGSWSKKAIKEAKKYGEVNVAASSEDDGFTYIPPldEWQLSDDAAYVHYTSNETIDGTEFHE 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2474877695 157 IPET-DAPLVADMSSDIFSRTFDYSKFDLFYAGAQKNMGPAGTTLVIVKESLLGKVSRAIPSMMSYEVHASKDSMFNTPP 235
Cdd:PRK05355  161 LPDTgDVPLVADMSSDILSRPIDVSKFGLIYAGAQKNIGPAGLTIVIVREDLLGRALPSIPSMLDYKTHADNDSMYNTPP 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2474877695 236 VFAVYTSMLNMRWIESQGGIRSLGDKNSVKSTLLYGEIDRNSLFEGFAAKEDRSDMNATFNLKDTAYTEAFDSLCQTAGI 315
Cdd:PRK05355  241 TFAIYLAGLVFKWLKEQGGVAAMEKRNQEKAALLYDAIDSSDFYRNPVAPEDRSRMNVPFTLADEELDKKFLAEAKAAGL 320
                         330       340       350
                  ....*....|....*....|....*....|....*...
gi 2474877695 316 SGLKGHRSVGGYRASMYNAMSIESVEILVDCMQILEKK 353
Cdd:PRK05355  321 VGLKGHRSVGGMRASIYNAMPLEGVQALVDFMKEFERR 358
PSAT_like cd00611
Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP) ...
4-352 1.07e-151

Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as a dimer and catalyzes the conversion of phosphohydroxypyruvate to phosphoserine.


Pssm-ID: 99736 [Multi-domain]  Cd Length: 355  Bit Score: 430.95  E-value: 1.07e-151
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2474877695   4 HNFSAGPSILPKEVMHQAAEAVKELDGSKLSLIEISHRSKAFIDIMDEACERALRLTGLEgKGYKAIFLQGGASLQFLMA 83
Cdd:cd00611     1 INFSAGPAALPEEVLEQAQKELLDFNGLGMSVMEMSHRSKDFEAIVNEAESDLRELLNIP-DNYKVLFLQGGATGQFAAV 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2474877695  84 AYNLL--ENKAGYLNTGTWSDKAIKEAKLFGEVIEIASSKD-QNYNHIPKDYSIP--SGLDYLHLTTNNTIFGTQFKSIP 158
Cdd:cd00611    80 PLNLLgdKGTADYVVTGAWSAKAAKEAKRYGGVVVIVAAKEeGKYTKIPDVETWDlaPDAAYVHYCSNETIHGVEFDEVP 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2474877695 159 ET-DAPLVADMSSDIFSRTFDYSKFDLFYAGAQKNMGPAGTTLVIVKESLLGKVSRAIPSMMSYEVHASKDSMFNTPPVF 237
Cdd:cd00611   160 DTgGVPLVADMSSNILSRPIDVSKFGVIYAGAQKNLGPAGVTVVIVRKDLLGKARKITPSMLNYKTHADNNSLYNTPPTF 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2474877695 238 AVYTSMLNMRWIESQGGIRSLGDKNSVKSTLLYGEIDRNS-LFEGFAAKEDRSDMNATFNLKDTAYTEAFDSLCQTAGIS 316
Cdd:cd00611   240 AIYMMGLVLKWLKEQGGVEAMEKRNRQKAQLLYDTIDNSNgFYRGPVDKRARSRMNVPFRLGKEELEKEFLKEAEAAGMI 319
                         330       340       350
                  ....*....|....*....|....*....|....*.
gi 2474877695 317 GLKGHRSVGGYRASMYNAMSIESVEILVDCMQILEK 352
Cdd:cd00611   320 GLKGHRSVGGIRASIYNALSLEGVQALADFMKEFQK 355
serC_1 TIGR01364
phosphoserine aminotransferase; This model represents the common form of the phosphoserine ...
11-353 3.22e-141

phosphoserine aminotransferase; This model represents the common form of the phosphoserine aminotransferase SerC. The phosphoserine aminotransferase of the archaeon Methanosarcina barkeri and putative phosphoserine aminotransferase of Mycobacterium tuberculosis are represented by separate models. All are members of the class V aminotransferases (pfam00266). [Amino acid biosynthesis, Serine family]


Pssm-ID: 130431  Cd Length: 349  Bit Score: 403.97  E-value: 3.22e-141
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2474877695  11 SILPKEVMHQAAEAVKELDGSKLSLIEISHRSKAFIDIMDEAcERALR-LTGLEgKGYKAIFLQGGASLQFLMAAYNLLE 89
Cdd:TIGR01364   1 AALPEEVLEQAQKELLNFNGTGMSVMEISHRSKEFEAVANEA-ESDLReLLNIP-DNYEVLFLQGGATGQFAAVPLNLLA 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2474877695  90 N--KAGYLNTGTWSDKAIKEAKLFGEVIEIASSKDQNYNHIP--KDYSIPSGLDYLHLTTNNTIFGTQFKSIPE-TDAPL 164
Cdd:TIGR01364  79 EgkVADYIVTGAWSKKAAKEAKKYGVVNVVASGKEGNYTKIPdpSTWEISEDAAYVHYCANETIHGVEFRELPDvKNAPL 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2474877695 165 VADMSSDIFSRTFDYSKFDLFYAGAQKNMGPAGTTLVIVKESLLGKVSRAIPSMMSYEVHASKDSMFNTPPVFAVYTSML 244
Cdd:TIGR01364 159 VADMSSNILSRPIDVSKFGLIYAGAQKNIGPAGLTVVIVRKDLLGRASRITPSMLNYKIHAENDSMYNTPPTFAIYVSGL 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2474877695 245 NMRWIESQGGIRSLGDKNSVKSTLLYGEIDRNS-LFEGFAAKEDRSDMNATFNLKDTAYTEAFDSLCQTAGISGLKGHRS 323
Cdd:TIGR01364 239 VFKWLKEQGGVKAIEKRNQAKAQLLYDTIDNSNgFYRNPVDPRNRSRMNVVFTLGNEELEKRFLKEAEERGLVSLKGHRS 318
                         330       340       350
                  ....*....|....*....|....*....|
gi 2474877695 324 VGGYRASMYNAMSIESVEILVDCMQILEKK 353
Cdd:TIGR01364 319 VGGMRASIYNAMPLEGVQALVDFMKEFQKK 348
PLN02452 PLN02452
phosphoserine transaminase
2-348 2.60e-113

phosphoserine transaminase


Pssm-ID: 178071  Cd Length: 365  Bit Score: 333.97  E-value: 2.60e-113
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2474877695   2 RLHNFSAGPSILPKEVMHQAAEAVKELDGSKLSLIEISHRSKAFIDIMDEACERALRLTGLEGKgYKAIFLQGGASLQFL 81
Cdd:PLN02452    7 RVFNFSAGPATLPANVLAKAQAELYNWEGSGMSVMEMSHRGKEFLSIIQKAEADLRELLDIPDN-YEVLFLQGGASTQFA 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2474877695  82 MAAYNLL--ENKAGYLNTGTWSDKAIKEAKLFGEVIEIASSKDQNYNHIP--KDYSIPSGLDYLHLTTNNTIFGTQFKSI 157
Cdd:PLN02452   86 AIPLNLCkpGDKADFVVTGSWSKKAAKEAKKYCKTNVIASGKDEKYTKIPsvSEWELTPDAKFVHICANETIHGVEFKDY 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2474877695 158 PET-DAPLVADMSSDIFSRTFDYSKFDLFYAGAQKNMGPAGTTLVIVKESLLGKVSRAIPSMMSYEVHASKDSMFNTPPV 236
Cdd:PLN02452  166 PDVgNVPLVADMSSNFLSKPVDVSKYGVIYAGAQKNVGPSGVTIVIIRKDLIGNARPITPGMLDYKIHAENDSLYNTPPC 245
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2474877695 237 FAVYTSMLNMRWIESQGGIRSLGDKNSVKSTLLYGEIDrNSlfEGF----AAKEDRSDMNATFNLKDTAYTEAFDSLCQT 312
Cdd:PLN02452  246 FGIYMCGLVFEDLLAQGGLKAMEKRNIRKADLLYDAID-ES--NGFyvcpVEKSVRSLMNVPFTLGGSELEAEFVKEAAK 322
                         330       340       350
                  ....*....|....*....|....*....|....*.
gi 2474877695 313 AGISGLKGHRSVGGYRASMYNAMSIESVEILVDCMQ 348
Cdd:PLN02452  323 AGMVQLKGHRSVGGMRASIYNAMPLAGVEKLVAFMK 358
PRK12462 PRK12462
phosphoserine aminotransferase; Provisional
5-354 7.95e-106

phosphoserine aminotransferase; Provisional


Pssm-ID: 183540  Cd Length: 364  Bit Score: 314.83  E-value: 7.95e-106
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2474877695   5 NFSAGPSILPKEVMHQAAEAVKELDGSKLSLIEISHRSKAFIDIMDEAcERALR-LTGLEgKGYKAIFLQGGASLQFLMA 83
Cdd:PRK12462    7 NFSGGPGALPDTVLEQVRQAVVELPETGLSVLGMSHRSSWFSSLLAQA-EADLRdLLGIP-DEYGVVFLQGGSSLQFSMI 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2474877695  84 AYNLLENKAG---YLNTGTWSDKAIKEAKLFGEVIEIASSKDQNYNHIPKDYSIPSGLD--YLHLTTNNTIFGTQFKSIP 158
Cdd:PRK12462   85 PMNFSRPGAAapeYVTTGYWSRKAIGEASRVAAMRVVWDGAASGYRTLPSLAELDWDARapFRHYVSNETVEGLQFPDAA 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2474877695 159 ETD-APLVADMSSDIFSRTFDYSKFDLFYAGAQKNMGPAGTTLVIVKESLLGKVSRAIPSMMSYEVHASKDSMFNTPPVF 237
Cdd:PRK12462  165 GLPdSPLIADMSSDFMSRPFDVEAYGMVYAHAQKNLGPAGVTVAIIRRALLERVPDTLPPMLDFRTHVEHRSNYNTPPVF 244
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2474877695 238 AVYTSMLNMRWIESQ-GGIRSLGDKNSVKSTLLYGEIDR-NSLFEGFAAKEDRSDMNATFNLKDTAYTEAFDSLCQTAGI 315
Cdd:PRK12462  245 AIYVMALVLRWIRDEiGGVHAMRDINARKAAMLYATLDAlNEVIDCHAHRAARSTMNVAFRFRQPRLDTLFKEQSTEAGF 324
                         330       340       350
                  ....*....|....*....|....*....|....*....
gi 2474877695 316 SGLKGHRSVGGYRASMYNAMSIESVEILVDCMQILEKKQ 354
Cdd:PRK12462  325 CGLSGHRSIGGIRASLYNAVSEQAVSRLCAFLKDFAIRH 363
Aminotran_5 pfam00266
Aminotransferase class-V; This domain is found in amino transferases, and other enzymes ...
5-343 5.49e-30

Aminotransferase class-V; This domain is found in amino transferases, and other enzymes including cysteine desulphurase EC:4.4.1.-.


Pssm-ID: 425567 [Multi-domain]  Cd Length: 368  Bit Score: 117.73  E-value: 5.49e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2474877695   5 NFSAGPSILPKEVMHQAAEAVKELDGSKLSliEISHRSKAFIDIMDEACERALRLTGLEGKgYKAIFLQGGASlQFLMAA 84
Cdd:pfam00266   3 LDSAATTQKPQEVLDAIQEYYTDYNGNVHR--GVHTLGKEATQAYEEAREKVAEFINAPSN-DEIIFTSGTTE-AINLVA 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2474877695  85 YNLLEN-KAG----YLNTGTWSDK-AIKEAKLFG--EVIEIASSKDQNYNHIPKDYSIPSGLDYLHLTTNNTIFGTQF-- 154
Cdd:pfam00266  79 LSLGRSlKPGdeivITEMEHHANLvPWQELAKRTgaRVRVLPLDEDGLLDLDELEKLITPKTKLVAITHVSNVTGTIQpv 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2474877695 155 ----KSIPETDAPLVADMSSDIFSRTFDYSKF--DLFYAGAQKNMGPAGTTLVIVKESLLGKVS--------RAIPSmMS 220
Cdd:pfam00266 159 peigKLAHQYGALVLVDAAQAIGHRPIDVQKLgvDFLAFSGHKLYGPTGIGVLYGRRDLLEKMPpllggggmIETVS-LQ 237
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2474877695 221 YEVHASKDSMFN--TPPVFAVYTSMLNMRWIESqGGIRSLGDKNSVKSTLLYGEIDRNSLFEGFAAKEDRSDMNATFNLK 298
Cdd:pfam00266 238 ESTFADAPWKFEagTPNIAGIIGLGAALEYLSE-IGLEAIEKHEHELAQYLYERLLSLPGIRLYGPERRASIISFNFKGV 316
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2474877695 299 DTAYTEafdSLCQTAGISGLKGHRSV----------GGYRASMYNAMSIESVEIL 343
Cdd:pfam00266 317 HPHDVA---TLLDESGIAVRSGHHCAqplmvrlglgGTVRASFYIYNTQEDVDRL 368
AGAT_like cd06451
Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate ...
6-240 3.25e-08

Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT), serine-glyoxylate aminotransferase (SGAT), and 3-hydroxykynurenine transaminase (HKT). AGAT is a homodimeric protein, which catalyses the transamination of glyoxylate to glycine, and SGAT converts serine and glyoxylate to hydroxypyruvate and glycine. HKT catalyzes the PLP-dependent transamination of 3-hydroxykynurenine, a potentially toxic metabolite of the kynurenine pathway.


Pssm-ID: 99744 [Multi-domain]  Cd Length: 356  Bit Score: 54.60  E-value: 3.25e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2474877695   6 FSAGPSILPKEVMhQAaeavkeldgskLSLIEISHRSKAFIDIMDEACERALRLTGLEgkGYKAIFLQGGASLQFLMAAY 85
Cdd:cd06451     3 LIPGPSNVPPRVL-KA-----------MNRPMLGHRSPEFLALMDEILEGLRYVFQTE--NGLTFLLSGSGTGAMEAALS 68
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2474877695  86 NLLENKAGYLN--TGTWSDKAIKEAKLFG-EVIEIASSKDQNYNhiPKDY-SIPSGLDY--LHLTTNNTIFGTQF----- 154
Cdd:cd06451    69 NLLEPGDKVLVgvNGVFGDRWADMAERYGaDVDVVEKPWGEAVS--PEEIaEALEQHDIkaVTLTHNETSTGVLNplegi 146
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2474877695 155 -KSIPETDAPLVADMSSDIFSRTFDYSKF--DLFYAGAQKNMG-PAGTTLVIVKESLLGKVSRAIPSMMSY-------EV 223
Cdd:cd06451   147 gALAKKHDALLIVDAVSSLGGEPFRMDEWgvDVAYTGSQKALGaPPGLGPIAFSERALERIKKKTKPKGFYfdlllllKY 226
                         250
                  ....*....|....*..
gi 2474877695 224 HASKDSMFNTPPVFAVY 240
Cdd:cd06451   227 WGEGYSYPHTPPVNLLY 243
PRK03080 PRK03080
phosphoserine transaminase;
5-307 1.63e-07

phosphoserine transaminase;


Pssm-ID: 235103  Cd Length: 378  Bit Score: 52.50  E-value: 1.63e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2474877695   5 NFSAGPSILPKEvmhqaaeavKELDGSKLSLIEISHRSKAFIDIMDEACERALRLTGLEgKGYKAIFLQGGASLQFLMAA 84
Cdd:PRK03080   15 RFSSGPCKKRPG---------WQLEALADALLGRSHRQKPVKALLKRVIEGTRELLSLP-EGYEVGIVPGSDTGAWEMAL 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2474877695  85 YNLL-ENKAGYLNTGTWSDK----AIKEAKLfGEVIEIASskdqNYNHIPKdysiPSGLDYLH---LTTNNTIFGTQFKS 156
Cdd:PRK03080   85 WSLLgARRVDHLAWESFGSKwatdVVKQLKL-EDPRVLEA----DYGSLPD----LSAVDFDRdvvFTWNGTTTGVRVPV 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2474877695 157 ---IPETDAPLVA-DMSSDIFSRTFDYSKFDLFYAGAQKNMG-PAGTTLVIVK-------ESLlgKVSRAIP---SMMSY 221
Cdd:PRK03080  156 arwIGADREGLTIcDATSAAFALPLDWSKLDVYTFSWQKVLGgEGGHGMAILSpraverlESY--TPARPIPkffRLTKG 233
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2474877695 222 E--VHAS-KDSMFNTPPVFAVYTSMLNMRWIESQGGIRSLGDKNSVKSTLLYGEIDRNSLFEGFAAK-EDRSDMNATFNL 297
Cdd:PRK03080  234 GkaIENSfKGQTINTPSMLTVEDYLDQLDWANSIGGLDALIARTAANASVLYDWAEKTPWATPLVADpATRSNTSVTLDF 313
                         330
                  ....*....|
gi 2474877695 298 KDTayTEAFD 307
Cdd:PRK03080  314 VDA--QAAVD 321
AAT_I cd01494
Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP) ...
49-204 1.81e-07

Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the substrate in four kinds of reactions (1) transamination (movement of amino groups), (2) racemization (redistribution of enantiomers), (3) decarboxylation (removing COOH groups), and (4) various side-chain reactions depending on the enzyme involved. Pyridoxal phosphate (PLP) dependent enzymes were previously classified into alpha, beta and gamma classes, based on the chemical characteristics (carbon atom involved) of the reaction they catalyzed. The availability of several structures allowed a comprehensive analysis of the evolutionary classification of PLP dependent enzymes, and it was found that the functional classification did not always agree with the evolutionary history of these enzymes. Structure and sequence analysis has revealed that the PLP dependent enzymes can be classified into four major groups of different evolutionary origin: aspartate aminotransferase superfamily (fold type I), tryptophan synthase beta superfamily (fold type II), alanine racemase superfamily (fold type III), and D-amino acid superfamily (fold type IV) and Glycogen phophorylase family (fold type V).


Pssm-ID: 99742 [Multi-domain]  Cd Length: 170  Bit Score: 50.46  E-value: 1.81e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2474877695  49 MDEACERALRLTGlegKGYKAIFLQGGASLQFLMAAYNLLENKAG--YLNTGTWSDKAIKEAKLFGEVIEIASSKDQ--- 123
Cdd:cd01494     2 LEELEEKLARLLQ---PGNDKAVFVPSGTGANEAALLALLGPGDEviVDANGHGSRYWVAAELAGAKPVPVPVDDAGygg 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2474877695 124 NYNHIPKDYSIPSGLDYLHLTTNNTIFG-----TQFKSIP-ETDAPLVADMSSDIFSRTF-----DYSKFDLFYAGAQKN 192
Cdd:cd01494    79 LDVAILEELKAKPNVALIVITPNTTSGGvlvplKEIRKIAkEYGILLLVDAASAGGASPApgvliPEGGADVVTFSLHKN 158
                         170
                  ....*....|..
gi 2474877695 193 MGPAGTTLVIVK 204
Cdd:cd01494   159 LGGEGGGVVIVK 170
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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