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Conserved domains on  [gi|123237050|emb|CAM26658|]
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rhomboid 5 homolog 1 (Drosophila), partial [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Rhomboid_SP super family cl13970
Rhomboid serine protease; This domain family is found in eukaryotes, and is approximately 210 ...
 91-163 8.59e-42

Rhomboid serine protease; This domain family is found in eukaryotes, and is approximately 210 amino acids in length. The family is found in association with pfam01694. Rhomboid is a seven-transmembrane spanning protein that resides in the Golgi and acts as a serine protease to cleave Spitz.


The actual alignment was detected with superfamily member pfam12595:

Pssm-ID: 463639  Cd Length: 193  Bit Score: 138.08  E-value: 8.59e-42
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 123237050   91 VSKDSDSTQKWQRKSIRHCSQRYGKLKPQVLRELDLPSQDNVSLTSTETPPPLYVGPCQLGMQKIIDPLARGR 163
Cdd:pfam12595   1 VSKDSDSTQRWQRKSLRHCSMRYGKLKPQVIREMELPSQDNPSLTSTETPPPLYLPKSHHGMQRIVDPLARGR 73
 
Name Accession Description Interval E-value
Rhomboid_SP pfam12595
Rhomboid serine protease; This domain family is found in eukaryotes, and is approximately 210 ...
 91-163 8.59e-42

Rhomboid serine protease; This domain family is found in eukaryotes, and is approximately 210 amino acids in length. The family is found in association with pfam01694. Rhomboid is a seven-transmembrane spanning protein that resides in the Golgi and acts as a serine protease to cleave Spitz.


Pssm-ID: 463639  Cd Length: 193  Bit Score: 138.08  E-value: 8.59e-42
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 123237050   91 VSKDSDSTQKWQRKSIRHCSQRYGKLKPQVLRELDLPSQDNVSLTSTETPPPLYVGPCQLGMQKIIDPLARGR 163
Cdd:pfam12595   1 VSKDSDSTQRWQRKSLRHCSMRYGKLKPQVIREMELPSQDNPSLTSTETPPPLYLPKSHHGMQRIVDPLARGR 73
 
Name Accession Description Interval E-value
Rhomboid_SP pfam12595
Rhomboid serine protease; This domain family is found in eukaryotes, and is approximately 210 ...
 91-163 8.59e-42

Rhomboid serine protease; This domain family is found in eukaryotes, and is approximately 210 amino acids in length. The family is found in association with pfam01694. Rhomboid is a seven-transmembrane spanning protein that resides in the Golgi and acts as a serine protease to cleave Spitz.


Pssm-ID: 463639  Cd Length: 193  Bit Score: 138.08  E-value: 8.59e-42
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 123237050   91 VSKDSDSTQKWQRKSIRHCSQRYGKLKPQVLRELDLPSQDNVSLTSTETPPPLYVGPCQLGMQKIIDPLARGR 163
Cdd:pfam12595   1 VSKDSDSTQRWQRKSLRHCSMRYGKLKPQVIREMELPSQDNPSLTSTETPPPLYLPKSHHGMQRIVDPLARGR 73
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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