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Conserved domains on  [gi|218365270|emb|CAR02991|]
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putative inner membrane oxidoreductase [Escherichia coli S88]

Protein Classification

electron transport complex subunit D( domain architecture ID 10011536)

electron transport complex subunit D is part of the Rnf complex that functions as a redox-driven ion pump, coupling an oxidoreduction process to the translocation of Na+ across the cell membrane

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
rnfD PRK00816
electron transport complex protein RnfD; Reviewed
2-351 0e+00

electron transport complex protein RnfD; Reviewed


:

Pssm-ID: 234844  Cd Length: 350  Bit Score: 663.89  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218365270   2 VFRIASSPYTHNQRQTSRIMLLVLLAAVPGIAAQLWFFGWGTLVQILLASVSALLAEALVLKLRKQSVAATLKDNSALLT 81
Cdd:PRK00816   1 AFKIASSPHTHNQRQTSRIMLWVILAALPGIAAQTYFFGWGTLIQILLAIVTALLAEAAVLKLRKRPVAATLKDNSALLT 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218365270  82 GLLLAVSIPPLAPWWMVVLGTVFAVIIAKQLYGGLGQNPFNPAMIGYVVLLISFPVQMTSWLPPHEIAVNIPGFIDAIQV 161
Cdd:PRK00816  81 ALLLAVSIPPLAPWWMIVIGTVFAIIIAKQLYGGLGQNPFNPAMVGYVVLLISFPVQMTSWLPPIELAAEPPGFLDALSL 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218365270 162 IFSGHTTSGGDMNTLRLGIDGISQATPLDTFKTSVRAGHSVEEIMQYPIYSGILAGAGWQWVNLAWLAGGVWLLWQKAIR 241
Cdd:PRK00816 161 IFTGHTADGFDMHQLRLGIDGISQATPLDTFKTSLRAGHTVEEILQQPIFSGILAGVGWQWVNLAYLAGGLFLLWQKAIR 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218365270 242 WHVPLSFLVTLALCATLGWLFSPDTLAAPQIHLLSGATMLGAFFILTDPVTASTTNRGRLIFGALAGLLVWMIRSFGGYP 321
Cdd:PRK00816 241 WHIPVAFLATLALCATLGWLFSPDTLASPLLHLFSGATMLGAFFIATDPVTASTTPRGRLIFGALIGLLVYLIRSFGGYP 320
                        330       340       350
                 ....*....|....*....|....*....|
gi 218365270 322 DGVAFAVLLANITVPLIDYYTRPRVYGHRK 351
Cdd:PRK00816 321 DGVAFAVLLANICVPLIDYYTRPRVYGHRK 350
 
Name Accession Description Interval E-value
rnfD PRK00816
electron transport complex protein RnfD; Reviewed
2-351 0e+00

electron transport complex protein RnfD; Reviewed


Pssm-ID: 234844  Cd Length: 350  Bit Score: 663.89  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218365270   2 VFRIASSPYTHNQRQTSRIMLLVLLAAVPGIAAQLWFFGWGTLVQILLASVSALLAEALVLKLRKQSVAATLKDNSALLT 81
Cdd:PRK00816   1 AFKIASSPHTHNQRQTSRIMLWVILAALPGIAAQTYFFGWGTLIQILLAIVTALLAEAAVLKLRKRPVAATLKDNSALLT 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218365270  82 GLLLAVSIPPLAPWWMVVLGTVFAVIIAKQLYGGLGQNPFNPAMIGYVVLLISFPVQMTSWLPPHEIAVNIPGFIDAIQV 161
Cdd:PRK00816  81 ALLLAVSIPPLAPWWMIVIGTVFAIIIAKQLYGGLGQNPFNPAMVGYVVLLISFPVQMTSWLPPIELAAEPPGFLDALSL 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218365270 162 IFSGHTTSGGDMNTLRLGIDGISQATPLDTFKTSVRAGHSVEEIMQYPIYSGILAGAGWQWVNLAWLAGGVWLLWQKAIR 241
Cdd:PRK00816 161 IFTGHTADGFDMHQLRLGIDGISQATPLDTFKTSLRAGHTVEEILQQPIFSGILAGVGWQWVNLAYLAGGLFLLWQKAIR 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218365270 242 WHVPLSFLVTLALCATLGWLFSPDTLAAPQIHLLSGATMLGAFFILTDPVTASTTNRGRLIFGALAGLLVWMIRSFGGYP 321
Cdd:PRK00816 241 WHIPVAFLATLALCATLGWLFSPDTLASPLLHLFSGATMLGAFFIATDPVTASTTPRGRLIFGALIGLLVYLIRSFGGYP 320
                        330       340       350
                 ....*....|....*....|....*....|
gi 218365270 322 DGVAFAVLLANITVPLIDYYTRPRVYGHRK 351
Cdd:PRK00816 321 DGVAFAVLLANICVPLIDYYTRPRVYGHRK 350
RnfD COG4658
Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfD subunit [Energy production and ...
3-350 1.05e-180

Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfD subunit [Energy production and conversion]; Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfD subunit is part of the Pathway/BioSystem: Na+-translocating Fd:NADH oxidoreductase


Pssm-ID: 443696  Cd Length: 332  Bit Score: 503.50  E-value: 1.05e-180
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218365270   3 FRIASSPYTHNQRQTSRIMLLVLLAAVPGIAAQLWFFGWGTLVQILLASVSALLAEALVLKLRKQSVaaTLKDNSALLTG 82
Cdd:COG4658    4 LKVSSSPHIHSGDSTSRIMLDVLLALLPALAAGVYFFGWGALIVILLAVLTAVLTEALILKLRKRPP--TLGDGSAVVTG 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218365270  83 LLLAVSIPPLAPWWMVVLGTVFAVIIAKQLYGGLGQNPFNPAMIGYVVLLISFPVQMTSWLPPHEIAvniPGFIDAIQVI 162
Cdd:COG4658   82 LLLALSLPPTAPWWMVVIGSFFAIVVAKQLFGGLGQNPFNPAMVGRAFLLISFPVQMTTWLPPAPLA---AGFLDSLALI 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218365270 163 FSGhttsggdmntlrLGIDGISQATPLDTFKTSVRAgHSVEEIMQYPIYsGILAGAGWQWVNLAWLAGGVWLLWQKAIRW 242
Cdd:COG4658  159 FTG------------GGVDAVTGATPLDALKTGLSA-LTVSEILQDLFF-GNIGGSGGETSALALLLGGLYLLYRRIISW 224
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218365270 243 HVPLSFLVTLALCATLGWLFSPDTLAAPQIHLLSGATMLGAFFILTDPVTASTTNRGRLIFGALAGLLVWMIRSFGGYPD 322
Cdd:COG4658  225 HIPVAYLGTVAVLAGLFGLIDPDRYASPLFHLLSGGLMLGAFFMATDPVTSPTTPKGRLIFGAGIGLLTYLIRTFGGYPE 304
                        330       340
                 ....*....|....*....|....*...
gi 218365270 323 GVAFAVLLANITVPLIDYYTRPRVYGHR 350
Cdd:COG4658  305 GVAFAILLMNAAVPLIDRYTRPRVFGHV 332
rnfD TIGR01946
electron transport complex, RnfABCDGE type, D subunit; The six subunit complex RnfABCDGE in ...
8-349 2.51e-175

electron transport complex, RnfABCDGE type, D subunit; The six subunit complex RnfABCDGE in Rhodobacter capsulatus encodes an apparent NADH oxidoreductase responsible for electron transport to nitrogenase, necessary for nitrogen fixation. A closely related complex in E. coli, RsxABCDGE (Reducer of SoxR), reduces the 2Fe-2S-containing superoxide sensor SoxR, active as a transcription factor when oxidized. This family of putative NADH oxidoreductase complexes exists in many of the same species as the related NQR, a Na(+)-translocating NADH-quinone reductase, but is distinct. This model describes the A subunit. [Energy metabolism, Electron transport]


Pssm-ID: 131001  Cd Length: 327  Bit Score: 489.57  E-value: 2.51e-175
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218365270    8 SPYTHNQRQTSRIMLLVLLAAVPGIAAQLWFFGWGTLVQILLASVSALLAEALVLKLRKQSVAATLKDNSALLTGLLLAV 87
Cdd:TIGR01946   1 SPHIRSGDSTRKIMRDVLIALLPGLAAQVYFFGWGTLIQIALAILTALILEAAILKLRKRSIKAFLKDGSAILTGLLLAV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218365270   88 SIPPLAPWWMVVLGTVFAVIIAKQLYGGLGQNPFNPAMIGYVVLLISFPVQMTSWLPPHEIAvnipGFIDAIQVIFSGHT 167
Cdd:TIGR01946  81 AIPPLAPWWMIVIGTIFAIVLGKHLYGGLGQNIFNPAMVGYVFLLISFPVQMTTWPPPGKLL----SFVDSFSLIFSGNT 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218365270  168 TsggdmntlrlGIDGISQATPLDTFKTSVRAGHSVEeIMQYPIYSGILAGAGWQWVNLAWLAGGVWLLWQKAIRWHVPLS 247
Cdd:TIGR01946 157 S----------GIDGITTATPLDLFKTGLSLGTDLL-PPKLPIFLGKSAGCGWEWSNLAFLLGGIYLLYRKIITWHIPVS 225
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218365270  248 FLVTLALCATLGWLFSPDTLAAPQIHLLSGATMLGAFFILTDPVTASTTNRGRLIFGALAGLLVWMIRSFGGYPDGVAFA 327
Cdd:TIGR01946 226 MLATLFVLSTITYLFSPFTHASPLFHLFSGGTMLGAFFIATDPVTAPTTNKGRIIFGAGIGVLVYLIRTFGGYPDGVAFA 305
                         330       340
                  ....*....|....*....|..
gi 218365270  328 VLLANITVPLIDYYTRPRVYGH 349
Cdd:TIGR01946 306 ILLMNLCVPLIDYYTRPRTYGH 327
NQR2_RnfD_RnfE pfam03116
NQR2, RnfD, RnfE family; This family of bacterial proteins includes a sodium-translocating ...
6-348 7.87e-139

NQR2, RnfD, RnfE family; This family of bacterial proteins includes a sodium-translocating NADH-ubiquinone oxidoreductase (i.e. a respiration linked sodium pump). In Vibrio cholerae, it negatively regulates the expression of virulence factors through inhibiting (by an unknown mechanism) the transcription of the transcriptional activator ToxT. The family also includes proteins involved in nitrogen fixation, RnfD and RnfE. The similarity of these proteins to NADH-ubiquinone oxidoreductases was previously noted.


Pssm-ID: 460811  Cd Length: 304  Bit Score: 396.02  E-value: 7.87e-139
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218365270    6 ASSPYTHNQRQTSRIMLLVLLAAVPGIAAQLWFFGWGTLVQILLASVSALLAEALVLKLRKQSVAaTLKDNSALLTGLLL 85
Cdd:pfam03116   1 SSSPHIRDGISTKRIMLDVLIALLPALLFGVYNFGLQALLVILVAVAVAVLTEALFAKLRKKKVT-TLGDLSAVVTGLLL 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218365270   86 AVSIPPLAPWWMVVLGTVFAVIIAKQLYGGLGQNPFNPAMIGYVVLLISFPVQMTSWLPPheiavnipgfidaiqvifsg 165
Cdd:pfam03116  80 ALNLPPTAPWWMVAIGSAFAIVVGKQLFGGLGQNFFNPALVGRAFLLISFPVAMTTWVAP-------------------- 139
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218365270  166 httsggdmntlrlgiDGISQATPLDTFKTSvraGHSVEEIMQYPIYSGILAGAGWQWVNLAWLAGGVWLLWQKAIRWHVP 245
Cdd:pfam03116 140 ---------------DAVTGATPLAQLKAG---GLFFGLISYLDLFLGNIPGSIGETSALALLIGGLYLLARRIISWRIP 201
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218365270  246 LSFLVTLALCATLGWLFSPDTLAAPQIHLLSGATMLGAFFILTDPVTASTTNRGRLIFGALAGLLVWMIRSFGGYPDGVA 325
Cdd:pfam03116 202 VSFLAGVAVLALLFGLSNPMFFADPLFHLLSGGLMLGAFFMATDPVTSPVTPKGKLIYGAGIGLLTVLIRVFGGYPEGVS 281
                         330       340
                  ....*....|....*....|...
gi 218365270  326 FAVLLANITVPLIDYYTRPRVYG 348
Cdd:pfam03116 282 FAILLMNLLVPLIDRYTRPRVFG 304
 
Name Accession Description Interval E-value
rnfD PRK00816
electron transport complex protein RnfD; Reviewed
2-351 0e+00

electron transport complex protein RnfD; Reviewed


Pssm-ID: 234844  Cd Length: 350  Bit Score: 663.89  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218365270   2 VFRIASSPYTHNQRQTSRIMLLVLLAAVPGIAAQLWFFGWGTLVQILLASVSALLAEALVLKLRKQSVAATLKDNSALLT 81
Cdd:PRK00816   1 AFKIASSPHTHNQRQTSRIMLWVILAALPGIAAQTYFFGWGTLIQILLAIVTALLAEAAVLKLRKRPVAATLKDNSALLT 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218365270  82 GLLLAVSIPPLAPWWMVVLGTVFAVIIAKQLYGGLGQNPFNPAMIGYVVLLISFPVQMTSWLPPHEIAVNIPGFIDAIQV 161
Cdd:PRK00816  81 ALLLAVSIPPLAPWWMIVIGTVFAIIIAKQLYGGLGQNPFNPAMVGYVVLLISFPVQMTSWLPPIELAAEPPGFLDALSL 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218365270 162 IFSGHTTSGGDMNTLRLGIDGISQATPLDTFKTSVRAGHSVEEIMQYPIYSGILAGAGWQWVNLAWLAGGVWLLWQKAIR 241
Cdd:PRK00816 161 IFTGHTADGFDMHQLRLGIDGISQATPLDTFKTSLRAGHTVEEILQQPIFSGILAGVGWQWVNLAYLAGGLFLLWQKAIR 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218365270 242 WHVPLSFLVTLALCATLGWLFSPDTLAAPQIHLLSGATMLGAFFILTDPVTASTTNRGRLIFGALAGLLVWMIRSFGGYP 321
Cdd:PRK00816 241 WHIPVAFLATLALCATLGWLFSPDTLASPLLHLFSGATMLGAFFIATDPVTASTTPRGRLIFGALIGLLVYLIRSFGGYP 320
                        330       340       350
                 ....*....|....*....|....*....|
gi 218365270 322 DGVAFAVLLANITVPLIDYYTRPRVYGHRK 351
Cdd:PRK00816 321 DGVAFAVLLANICVPLIDYYTRPRVYGHRK 350
RnfD COG4658
Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfD subunit [Energy production and ...
3-350 1.05e-180

Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfD subunit [Energy production and conversion]; Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfD subunit is part of the Pathway/BioSystem: Na+-translocating Fd:NADH oxidoreductase


Pssm-ID: 443696  Cd Length: 332  Bit Score: 503.50  E-value: 1.05e-180
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218365270   3 FRIASSPYTHNQRQTSRIMLLVLLAAVPGIAAQLWFFGWGTLVQILLASVSALLAEALVLKLRKQSVaaTLKDNSALLTG 82
Cdd:COG4658    4 LKVSSSPHIHSGDSTSRIMLDVLLALLPALAAGVYFFGWGALIVILLAVLTAVLTEALILKLRKRPP--TLGDGSAVVTG 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218365270  83 LLLAVSIPPLAPWWMVVLGTVFAVIIAKQLYGGLGQNPFNPAMIGYVVLLISFPVQMTSWLPPHEIAvniPGFIDAIQVI 162
Cdd:COG4658   82 LLLALSLPPTAPWWMVVIGSFFAIVVAKQLFGGLGQNPFNPAMVGRAFLLISFPVQMTTWLPPAPLA---AGFLDSLALI 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218365270 163 FSGhttsggdmntlrLGIDGISQATPLDTFKTSVRAgHSVEEIMQYPIYsGILAGAGWQWVNLAWLAGGVWLLWQKAIRW 242
Cdd:COG4658  159 FTG------------GGVDAVTGATPLDALKTGLSA-LTVSEILQDLFF-GNIGGSGGETSALALLLGGLYLLYRRIISW 224
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218365270 243 HVPLSFLVTLALCATLGWLFSPDTLAAPQIHLLSGATMLGAFFILTDPVTASTTNRGRLIFGALAGLLVWMIRSFGGYPD 322
Cdd:COG4658  225 HIPVAYLGTVAVLAGLFGLIDPDRYASPLFHLLSGGLMLGAFFMATDPVTSPTTPKGRLIFGAGIGLLTYLIRTFGGYPE 304
                        330       340
                 ....*....|....*....|....*...
gi 218365270 323 GVAFAVLLANITVPLIDYYTRPRVYGHR 350
Cdd:COG4658  305 GVAFAILLMNAAVPLIDRYTRPRVFGHV 332
rnfD TIGR01946
electron transport complex, RnfABCDGE type, D subunit; The six subunit complex RnfABCDGE in ...
8-349 2.51e-175

electron transport complex, RnfABCDGE type, D subunit; The six subunit complex RnfABCDGE in Rhodobacter capsulatus encodes an apparent NADH oxidoreductase responsible for electron transport to nitrogenase, necessary for nitrogen fixation. A closely related complex in E. coli, RsxABCDGE (Reducer of SoxR), reduces the 2Fe-2S-containing superoxide sensor SoxR, active as a transcription factor when oxidized. This family of putative NADH oxidoreductase complexes exists in many of the same species as the related NQR, a Na(+)-translocating NADH-quinone reductase, but is distinct. This model describes the A subunit. [Energy metabolism, Electron transport]


Pssm-ID: 131001  Cd Length: 327  Bit Score: 489.57  E-value: 2.51e-175
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218365270    8 SPYTHNQRQTSRIMLLVLLAAVPGIAAQLWFFGWGTLVQILLASVSALLAEALVLKLRKQSVAATLKDNSALLTGLLLAV 87
Cdd:TIGR01946   1 SPHIRSGDSTRKIMRDVLIALLPGLAAQVYFFGWGTLIQIALAILTALILEAAILKLRKRSIKAFLKDGSAILTGLLLAV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218365270   88 SIPPLAPWWMVVLGTVFAVIIAKQLYGGLGQNPFNPAMIGYVVLLISFPVQMTSWLPPHEIAvnipGFIDAIQVIFSGHT 167
Cdd:TIGR01946  81 AIPPLAPWWMIVIGTIFAIVLGKHLYGGLGQNIFNPAMVGYVFLLISFPVQMTTWPPPGKLL----SFVDSFSLIFSGNT 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218365270  168 TsggdmntlrlGIDGISQATPLDTFKTSVRAGHSVEeIMQYPIYSGILAGAGWQWVNLAWLAGGVWLLWQKAIRWHVPLS 247
Cdd:TIGR01946 157 S----------GIDGITTATPLDLFKTGLSLGTDLL-PPKLPIFLGKSAGCGWEWSNLAFLLGGIYLLYRKIITWHIPVS 225
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218365270  248 FLVTLALCATLGWLFSPDTLAAPQIHLLSGATMLGAFFILTDPVTASTTNRGRLIFGALAGLLVWMIRSFGGYPDGVAFA 327
Cdd:TIGR01946 226 MLATLFVLSTITYLFSPFTHASPLFHLFSGGTMLGAFFIATDPVTAPTTNKGRIIFGAGIGVLVYLIRTFGGYPDGVAFA 305
                         330       340
                  ....*....|....*....|..
gi 218365270  328 VLLANITVPLIDYYTRPRVYGH 349
Cdd:TIGR01946 306 ILLMNLCVPLIDYYTRPRTYGH 327
NQR2_RnfD_RnfE pfam03116
NQR2, RnfD, RnfE family; This family of bacterial proteins includes a sodium-translocating ...
6-348 7.87e-139

NQR2, RnfD, RnfE family; This family of bacterial proteins includes a sodium-translocating NADH-ubiquinone oxidoreductase (i.e. a respiration linked sodium pump). In Vibrio cholerae, it negatively regulates the expression of virulence factors through inhibiting (by an unknown mechanism) the transcription of the transcriptional activator ToxT. The family also includes proteins involved in nitrogen fixation, RnfD and RnfE. The similarity of these proteins to NADH-ubiquinone oxidoreductases was previously noted.


Pssm-ID: 460811  Cd Length: 304  Bit Score: 396.02  E-value: 7.87e-139
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218365270    6 ASSPYTHNQRQTSRIMLLVLLAAVPGIAAQLWFFGWGTLVQILLASVSALLAEALVLKLRKQSVAaTLKDNSALLTGLLL 85
Cdd:pfam03116   1 SSSPHIRDGISTKRIMLDVLIALLPALLFGVYNFGLQALLVILVAVAVAVLTEALFAKLRKKKVT-TLGDLSAVVTGLLL 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218365270   86 AVSIPPLAPWWMVVLGTVFAVIIAKQLYGGLGQNPFNPAMIGYVVLLISFPVQMTSWLPPheiavnipgfidaiqvifsg 165
Cdd:pfam03116  80 ALNLPPTAPWWMVAIGSAFAIVVGKQLFGGLGQNFFNPALVGRAFLLISFPVAMTTWVAP-------------------- 139
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218365270  166 httsggdmntlrlgiDGISQATPLDTFKTSvraGHSVEEIMQYPIYSGILAGAGWQWVNLAWLAGGVWLLWQKAIRWHVP 245
Cdd:pfam03116 140 ---------------DAVTGATPLAQLKAG---GLFFGLISYLDLFLGNIPGSIGETSALALLIGGLYLLARRIISWRIP 201
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218365270  246 LSFLVTLALCATLGWLFSPDTLAAPQIHLLSGATMLGAFFILTDPVTASTTNRGRLIFGALAGLLVWMIRSFGGYPDGVA 325
Cdd:pfam03116 202 VSFLAGVAVLALLFGLSNPMFFADPLFHLLSGGLMLGAFFMATDPVTSPVTPKGKLIYGAGIGLLTVLIRVFGGYPEGVS 281
                         330       340
                  ....*....|....*....|...
gi 218365270  326 FAVLLANITVPLIDYYTRPRVYG 348
Cdd:pfam03116 282 FAILLMNLLVPLIDRYTRPRVFG 304
NqrB COG1805
Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrB [Energy production and ...
79-341 2.00e-41

Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrB [Energy production and conversion]; Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrB is part of the Pathway/BioSystem: Na+-translocating NADH dehydrogenase


Pssm-ID: 441410  Cd Length: 402  Bit Score: 149.19  E-value: 2.00e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218365270  79 LLTGLLLAVSIPPLAPWWMVVLGTVFAVIIAKQLYGGLGQNPFNPAMIGYVVLLISFPVQMTSwlppheiavnipgfiDA 158
Cdd:COG1805  151 LVTGMLFPLILPPTIPLWQVALGISFGVVIGKEVFGGTGKNFLNPALTGRAFLFFAYPAQMSG---------------DK 215
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218365270 159 IQVifsghttsggdmntlrlGIDGISQATPLdtfktSVRAGHSVEeimqypiysGILAGAGWQWVN-------------- 224
Cdd:COG1805  216 VWV-----------------AVDGFSGATPL-----GQAAAGGLD---------AVGTGAGYSWMDaflgfipgsigets 264
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218365270 225 -LAWLAGGVWLLWQKAIRWHVPLSFLVTLALCATLGWLFSPDTLAA----PQIHLLSGATMLGAFFILTDPVTASTTNRG 299
Cdd:COG1805  265 tLAILIGAAILIVTGIASWRIMLGVFIGMIATSLLFNLIGSDTNPMfampWYWHLVLGGFAFGMVFMATDPVSAAMTNKG 344
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 218365270 300 RLIFGALAGLLVWMIRSFG-GYPDGVAFAVLLANITVPLIDYY 341
Cdd:COG1805  345 KWIYGFLIGFMTVLIRVVNpAYPEGMMLAILFANVFAPLIDHF 387
PRK05349 PRK05349
Na(+)-translocating NADH-quinone reductase subunit B; Provisional
79-341 1.86e-37

Na(+)-translocating NADH-quinone reductase subunit B; Provisional


Pssm-ID: 235425  Cd Length: 405  Bit Score: 138.84  E-value: 1.86e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218365270  79 LLTGLLLAVSIPPLAPWWMVVLGTVFAVIIAKQLYGGLGQNPFNPAMIGYVVLLISFPVQMTSwlppheiavnipgfiDA 158
Cdd:PRK05349 151 FVTSILFALILPPTIPLWQVALGISFGVVIAKEVFGGTGRNFLNPALAGRAFLFFAYPAQMSG---------------DA 215
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218365270 159 IQVifsghttsggdmntlrlGIDGISQATPLdtfktsvraGHSVEEIMQYPIYSGILAGAGWQ---WVN----------L 225
Cdd:PRK05349 216 VWV-----------------AVDGFSGATAL---------SQAAAGGLDALVNTVTGQPITWMdafLGFipgsigetstL 269
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218365270 226 AWLAGGVWLLWQKAIRWHVPLSFLVTLALCATLGWLFSPDTLAAPQI----HLLSGATMLGAFFILTDPVTASTTNRGRL 301
Cdd:PRK05349 270 AILIGGAILLFTRIASWRIVAGVMIGMIATSLLFNLIGSDTNPMFAMpwywHLVLGGFAFGMVFMATDPVSASFTNKGKW 349
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 218365270 302 IFGALAGLLVWMIRSFG-GYPDGVAFAVLLANITVPLIDYY 341
Cdd:PRK05349 350 IYGALIGFMTVLIRVVNpAYPEGMMLAILFANLFAPLFDYF 390
PRK01024 PRK01024
Na(+)-translocating NADH-quinone reductase subunit B; Provisional
31-341 5.77e-24

Na(+)-translocating NADH-quinone reductase subunit B; Provisional


Pssm-ID: 179207  Cd Length: 503  Bit Score: 102.55  E-value: 5.77e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218365270  31 GIAAQLWFfGWGTLVQILLASVS-ALLAEALVLKLRKQSVAATLkdnsaLLTGLLLAVSIPPLAPWWMVVLGTVFAVIIA 109
Cdd:PRK01024 109 GIGSILWA-GCKIFLPLLFISYAvGGTCEVLFAIIRKHKIAEGL-----LVTGILYPLILPPTIPYWMAALGIAFGVVVG 182
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218365270 110 KQLYGGLGQNPFNPAMIGYVVLLISFPVQMTS--WL--------------------------------------PPH--- 146
Cdd:PRK01024 183 KELFGGTGMNILNPALSGRAFLFFTFPAKMSGdvWVgsnpsrikesllkmnslagkshidgfsqstclqtlnstPPSvkr 262
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218365270 147 ----EIAVNIPGF-----IDAIQVIFSGHTTSGGDMNTLRLGIDGISQ--ATPLDTFKTSVRAGHSVEEIMQYPIYSGIL 215
Cdd:PRK01024 263 vhvdAIASNILHLehvptQDVIQSQFSTWTESHPGLTLDQLTLEQLQNfvTTPLAEGGLGLLPTQFDSAYSITDVIYGIG 342
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218365270 216 AGAGWQ--WVN----------LAWLAGGVWLLWQKAIRWHVPLSFLVTLALCAtlgWLF--------------SPDTLAA 269
Cdd:PRK01024 343 KFSTGNlfFGNilgslgetstFACLLGAIFLILTGIASWRTMLSFGLGAFFTA---WLFkimsilivgnagawAPAKFFI 419
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 218365270 270 PQI-HLLSGATMLGAFFILTDPVTASTTNRGRLIFGALAGLLVWMIRSFG-GYPDGVAFAVLLANITVPLIDYY 341
Cdd:PRK01024 420 PAYrHLFLGGLAFGLVFMATDPVSSPTMKLAKWIYGAFIGFMTIVIRLINpAYPEGVMLAILLGNVFAPLFDYF 493
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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