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Conserved domains on  [gi|223967439|emb|CAR93450|]
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CG4570-PA [Drosophila melanogaster]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HTH_Tnp_Tc3_2 super family cl09264
Transposase; Transposase proteins are necessary for efficient DNA transposition. This family ...
 84-164 1.34e-06

Transposase; Transposase proteins are necessary for efficient DNA transposition. This family includes the amino-terminal region of Tc1, Tc1A, Tc1B and Tc2B transposases of C.elegans. The region encompasses the specific DNA binding and second DNA recognition domains as well as an amino-terminal region of the catalytic domain of Tc3 as described in. Tc3 is a member of the Tc1/mariner family of transposable elements.


The actual alignment was detected with superfamily member pfam01498:

Pssm-ID: 366677 [Multi-domain]  Cd Length: 72  Bit Score: 44.92  E-value: 1.34e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223967439   84 RQIVeQMLSDNPHYTSIDVQRELARHGIEVSRRTLQRRISEIRSKGiRQPRGSPqpkepstfGLSEGAKKRRLAWATAHQ 163
Cdd:pfam01498   2 RRIV-RLVRKDPRITARDLANELKEAGKSVSRSTIRRRLRKAGLKG-RRPRKKP--------LLSKKNRKARLEFAREHL 71


                  .
gi 223967439  164 D 164
Cdd:pfam01498  72 N 72
Commd super family cl06336
COMM_Domain, a family of domains found at the C-terminus of HCarG, the copper metabolism gene ...
 9-123 7.68e-03

COMM_Domain, a family of domains found at the C-terminus of HCarG, the copper metabolism gene MURR1 product, and related proteins. Presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB. Murr1/Commd1 is a protein involved in copper homeostasis, which has also been identified as a regulator of the human delta epithelial sodium channel. HCaRG, a nuclear protein that might be involved in cell proliferation, is negatively regulated by extracellular calcium concentration, and its basal mRNA levels are higher in hypertensive animals.


The actual alignment was detected with superfamily member cd04750:

Pssm-ID: 471425 [Multi-domain]  Cd Length: 166  Bit Score: 36.14  E-value: 7.68e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223967439   9 SIVKALKGSNS--CEEIAQILECDVESVISCIrecellEGKTATLRLPQKLKTA-----APVAVAQEEEKKRDVGRPKVL 81
Cdd:cd04750    6 AIEFLFKGINQkkYEGAARKLEVEVETVQHGV------EALVYLLIESTKLKLSerdfqDSIEFLGFSDDLNEILLQLYE 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 223967439  82 ENRQIVEQMLS----DNPHYTSIDvqrelARHGIEVSRRTLQRRIS 123
Cdd:cd04750   80 SNRKEIRNILKelspDLPHYHNLE-----WRLDVQIASRSLRSQVK 120
 
Name Accession Description Interval E-value
HTH_Tnp_Tc3_2 pfam01498
Transposase; Transposase proteins are necessary for efficient DNA transposition. This family ...
 84-164 1.34e-06

Transposase; Transposase proteins are necessary for efficient DNA transposition. This family includes the amino-terminal region of Tc1, Tc1A, Tc1B and Tc2B transposases of C.elegans. The region encompasses the specific DNA binding and second DNA recognition domains as well as an amino-terminal region of the catalytic domain of Tc3 as described in. Tc3 is a member of the Tc1/mariner family of transposable elements.


Pssm-ID: 366677 [Multi-domain]  Cd Length: 72  Bit Score: 44.92  E-value: 1.34e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223967439   84 RQIVeQMLSDNPHYTSIDVQRELARHGIEVSRRTLQRRISEIRSKGiRQPRGSPqpkepstfGLSEGAKKRRLAWATAHQ 163
Cdd:pfam01498   2 RRIV-RLVRKDPRITARDLANELKEAGKSVSRSTIRRRLRKAGLKG-RRPRKKP--------LLSKKNRKARLEFAREHL 71


                  .
gi 223967439  164 D 164
Cdd:pfam01498  72 N 72
Commd2 cd04750
COMM_Domain containing protein 2. The COMM Domain is found at the C-terminus of a variety of ...
 9-123 7.68e-03

COMM_Domain containing protein 2. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB.


Pssm-ID: 240098 [Multi-domain]  Cd Length: 166  Bit Score: 36.14  E-value: 7.68e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223967439   9 SIVKALKGSNS--CEEIAQILECDVESVISCIrecellEGKTATLRLPQKLKTA-----APVAVAQEEEKKRDVGRPKVL 81
Cdd:cd04750    6 AIEFLFKGINQkkYEGAARKLEVEVETVQHGV------EALVYLLIESTKLKLSerdfqDSIEFLGFSDDLNEILLQLYE 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 223967439  82 ENRQIVEQMLS----DNPHYTSIDvqrelARHGIEVSRRTLQRRIS 123
Cdd:cd04750   80 SNRKEIRNILKelspDLPHYHNLE-----WRLDVQIASRSLRSQVK 120
 
Name Accession Description Interval E-value
HTH_Tnp_Tc3_2 pfam01498
Transposase; Transposase proteins are necessary for efficient DNA transposition. This family ...
 84-164 1.34e-06

Transposase; Transposase proteins are necessary for efficient DNA transposition. This family includes the amino-terminal region of Tc1, Tc1A, Tc1B and Tc2B transposases of C.elegans. The region encompasses the specific DNA binding and second DNA recognition domains as well as an amino-terminal region of the catalytic domain of Tc3 as described in. Tc3 is a member of the Tc1/mariner family of transposable elements.


Pssm-ID: 366677 [Multi-domain]  Cd Length: 72  Bit Score: 44.92  E-value: 1.34e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223967439   84 RQIVeQMLSDNPHYTSIDVQRELARHGIEVSRRTLQRRISEIRSKGiRQPRGSPqpkepstfGLSEGAKKRRLAWATAHQ 163
Cdd:pfam01498   2 RRIV-RLVRKDPRITARDLANELKEAGKSVSRSTIRRRLRKAGLKG-RRPRKKP--------LLSKKNRKARLEFAREHL 71


                  .
gi 223967439  164 D 164
Cdd:pfam01498  72 N 72
HTH_11 pfam08279
HTH domain; This family includes helix-turn-helix domains in a wide variety of proteins.
 84-131 4.41e-03

HTH domain; This family includes helix-turn-helix domains in a wide variety of proteins.


Pssm-ID: 429896 [Multi-domain]  Cd Length: 52  Bit Score: 34.72  E-value: 4.41e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 223967439   84 RQIVEQMLSDNPHYTSidvqRELARHgIEVSRRTLQRRISEIRSKGIR 131
Cdd:pfam08279   1 LQILQLLLEARGPISG----QELAEK-LGVSRRTIRRDIKILEELGVP 43
Commd2 cd04750
COMM_Domain containing protein 2. The COMM Domain is found at the C-terminus of a variety of ...
 9-123 7.68e-03

COMM_Domain containing protein 2. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB.


Pssm-ID: 240098 [Multi-domain]  Cd Length: 166  Bit Score: 36.14  E-value: 7.68e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223967439   9 SIVKALKGSNS--CEEIAQILECDVESVISCIrecellEGKTATLRLPQKLKTA-----APVAVAQEEEKKRDVGRPKVL 81
Cdd:cd04750    6 AIEFLFKGINQkkYEGAARKLEVEVETVQHGV------EALVYLLIESTKLKLSerdfqDSIEFLGFSDDLNEILLQLYE 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 223967439  82 ENRQIVEQMLS----DNPHYTSIDvqrelARHGIEVSRRTLQRRIS 123
Cdd:cd04750   80 SNRKEIRNILKelspDLPHYHNLE-----WRLDVQIASRSLRSQVK 120
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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