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Conserved domains on  [gi|238031132|emb|CAY69055|]
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Hypothetical protein PAS_chr2-1_0432 [Komagataella phaffii GS115]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GYF pfam02213
GYF domain; The GYF domain is named because of the presence of Gly-Tyr-Phe residues. The GYF ...
 165-209 7.65e-17

GYF domain; The GYF domain is named because of the presence of Gly-Tyr-Phe residues. The GYF domain is a proline-binding domain in CD2-binding protein Swiss:O95400.


:

Pssm-ID: 460496  Cd Length: 45  Bit Score: 74.54  E-value: 7.65e-17
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 238031132  165 WIYLDAQGQEQGPFDGLMMQGWFEANYLTPELRLRRKEESSFRTL 209
Cdd:pfam02213   1 WEYKDPQGEVQGPFSSAEMQEWYKAGYFPDDLPVRRVGDTEFYPL 45
tolA_full TIGR02794
TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the ...
 414-554 7.32e-04

TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the outer membrane complex of TolB and OprL (also called Pal). Most of the length of the protein consists of low-complexity sequence that may differ in both length and composition from one species to another, complicating efforts to discriminate TolA (the most divergent gene in the tol-pal system) from paralogs such as TonB. Selection of members of the seed alignment and criteria for setting scoring cutoffs are based largely conserved operon struction. //The Tol-Pal complex is required for maintaining outer membrane integrity. Also involved in transport (uptake) of colicins and filamentous DNA, and implicated in pathogenesis. Transport is energized by the proton motive force. TolA is an inner membrane protein that interacts with periplasmic TolB and with outer membrane porins ompC, phoE and lamB. [Transport and binding proteins, Other, Cellular processes, Pathogenesis]


:

Pssm-ID: 274303 [Multi-domain]  Cd Length: 346  Bit Score: 42.53  E-value: 7.32e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238031132  414 QQEELTKAKLRRQAEEARLQESLRLQRLKEQEKSKNEVSTSQKASDIAPWANTKVsgpplslRQIQELEAKQLQERKKK- 492
Cdd:TIGR02794  64 KKEQERQKKLEQQAEEAEKQRAAEQARQKELEQRAAAEKAAKQAEQAAKQAEEKQ-------KQAEEAKAKQAAEAKAKa 136

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 238031132  493 -QLNNVQNQPIAQRLSEGAASTSLPASATWAKTPvapvlATKSLTEIQKEQAEAQAQRLQSQA 554
Cdd:TIGR02794 137 eAEAERKAKEEAAKQAEEEAKAKAAAEAKKKAEE-----AKKKAEAEAKAKAEAEAKAKAEEA 194
 
Name Accession Description Interval E-value
GYF pfam02213
GYF domain; The GYF domain is named because of the presence of Gly-Tyr-Phe residues. The GYF ...
 165-209 7.65e-17

GYF domain; The GYF domain is named because of the presence of Gly-Tyr-Phe residues. The GYF domain is a proline-binding domain in CD2-binding protein Swiss:O95400.


Pssm-ID: 460496  Cd Length: 45  Bit Score: 74.54  E-value: 7.65e-17
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 238031132  165 WIYLDAQGQEQGPFDGLMMQGWFEANYLTPELRLRRKEESSFRTL 209
Cdd:pfam02213   1 WEYKDPQGEVQGPFSSAEMQEWYKAGYFPDDLPVRRVGDTEFYPL 45
GYF cd00072
GYF domain: contains conserved Gly-Tyr-Phe residues; Proline-binding domain in CD2-binding and ...
 163-217 3.05e-11

GYF domain: contains conserved Gly-Tyr-Phe residues; Proline-binding domain in CD2-binding and other proteins. Involved in signaling lymphocyte activity. Also present in other unrelated proteins (mainly unknown) derived from diverse eukaryotic species.


Pssm-ID: 238027  Cd Length: 57  Bit Score: 59.24  E-value: 3.05e-11
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 238031132 163 IQWIYLDAQGQEQGPFDGLMMQGWFEANYLTPELRLRR-KEESSFRTLAELVQSLG 217
Cdd:cd00072    2 VQWFYKDPQGEIQGPFSASQMLQWYQAGYFPDGLQVRRlDNGGEFYTLGDILFDLG 57
GYF smart00444
Contains conserved Gly-Tyr-Phe residues; Proline-binding domain in CD2-binding protein. ...
 163-218 1.83e-09

Contains conserved Gly-Tyr-Phe residues; Proline-binding domain in CD2-binding protein. Contains conserved Gly-Tyr-Phe residues.


Pssm-ID: 214666  Cd Length: 56  Bit Score: 53.88  E-value: 1.83e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 238031132   163 IQWIYLDAQGQEQGPFDGLMMQGWFEANYLTPELRLRRKEESSFRTLAELVQSLGD 218
Cdd:smart00444   1 VLWLYKDPDGEIQGPFTASQMSQWYQAGYFPDSLQIKRLNEPPYETLGDLDRLLGL 56
tolA_full TIGR02794
TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the ...
 414-554 7.32e-04

TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the outer membrane complex of TolB and OprL (also called Pal). Most of the length of the protein consists of low-complexity sequence that may differ in both length and composition from one species to another, complicating efforts to discriminate TolA (the most divergent gene in the tol-pal system) from paralogs such as TonB. Selection of members of the seed alignment and criteria for setting scoring cutoffs are based largely conserved operon struction. //The Tol-Pal complex is required for maintaining outer membrane integrity. Also involved in transport (uptake) of colicins and filamentous DNA, and implicated in pathogenesis. Transport is energized by the proton motive force. TolA is an inner membrane protein that interacts with periplasmic TolB and with outer membrane porins ompC, phoE and lamB. [Transport and binding proteins, Other, Cellular processes, Pathogenesis]


Pssm-ID: 274303 [Multi-domain]  Cd Length: 346  Bit Score: 42.53  E-value: 7.32e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238031132  414 QQEELTKAKLRRQAEEARLQESLRLQRLKEQEKSKNEVSTSQKASDIAPWANTKVsgpplslRQIQELEAKQLQERKKK- 492
Cdd:TIGR02794  64 KKEQERQKKLEQQAEEAEKQRAAEQARQKELEQRAAAEKAAKQAEQAAKQAEEKQ-------KQAEEAKAKQAAEAKAKa 136

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 238031132  493 -QLNNVQNQPIAQRLSEGAASTSLPASATWAKTPvapvlATKSLTEIQKEQAEAQAQRLQSQA 554
Cdd:TIGR02794 137 eAEAERKAKEEAAKQAEEEAKAKAAAEAKKKAEE-----AKKKAEAEAKAKAEAEAKAKAEEA 194
tolA PRK09510
cell envelope integrity inner membrane protein TolA; Provisional
 410-547 6.87e-03

cell envelope integrity inner membrane protein TolA; Provisional


Pssm-ID: 236545 [Multi-domain]  Cd Length: 387  Bit Score: 39.40  E-value: 6.87e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238031132 410 LREIQQEELTKAKLRRQAEEARLQESLRLQRLKEQEKSKNEVSTSQKASDIAPWANTKVSGPPLSLRQIQELEAKQLQER 489
Cdd:PRK09510  80 QRKKKEQQQAEELQQKQAAEQERLKQLEKERLAAQEQKKQAEEAAKQAALKQKQAEEAAAKAAAAAKAKAEAEAKRAAAA 159

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 238031132 490 KKKQLNNVQNQPIAQRLSEGAASTSLPASATWAKTPVApvLATKSLTEIQKEQAEAQA 547
Cdd:PRK09510 160 AKKAAAEAKKKAEAEAAKKAAAEAKKKAEAEAAAKAAA--EAKKKAEAEAKKKAAAEA 215
 
Name Accession Description Interval E-value
GYF pfam02213
GYF domain; The GYF domain is named because of the presence of Gly-Tyr-Phe residues. The GYF ...
 165-209 7.65e-17

GYF domain; The GYF domain is named because of the presence of Gly-Tyr-Phe residues. The GYF domain is a proline-binding domain in CD2-binding protein Swiss:O95400.


Pssm-ID: 460496  Cd Length: 45  Bit Score: 74.54  E-value: 7.65e-17
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 238031132  165 WIYLDAQGQEQGPFDGLMMQGWFEANYLTPELRLRRKEESSFRTL 209
Cdd:pfam02213   1 WEYKDPQGEVQGPFSSAEMQEWYKAGYFPDDLPVRRVGDTEFYPL 45
GYF cd00072
GYF domain: contains conserved Gly-Tyr-Phe residues; Proline-binding domain in CD2-binding and ...
 163-217 3.05e-11

GYF domain: contains conserved Gly-Tyr-Phe residues; Proline-binding domain in CD2-binding and other proteins. Involved in signaling lymphocyte activity. Also present in other unrelated proteins (mainly unknown) derived from diverse eukaryotic species.


Pssm-ID: 238027  Cd Length: 57  Bit Score: 59.24  E-value: 3.05e-11
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 238031132 163 IQWIYLDAQGQEQGPFDGLMMQGWFEANYLTPELRLRR-KEESSFRTLAELVQSLG 217
Cdd:cd00072    2 VQWFYKDPQGEIQGPFSASQMLQWYQAGYFPDGLQVRRlDNGGEFYTLGDILFDLG 57
GYF smart00444
Contains conserved Gly-Tyr-Phe residues; Proline-binding domain in CD2-binding protein. ...
 163-218 1.83e-09

Contains conserved Gly-Tyr-Phe residues; Proline-binding domain in CD2-binding protein. Contains conserved Gly-Tyr-Phe residues.


Pssm-ID: 214666  Cd Length: 56  Bit Score: 53.88  E-value: 1.83e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 238031132   163 IQWIYLDAQGQEQGPFDGLMMQGWFEANYLTPELRLRRKEESSFRTLAELVQSLGD 218
Cdd:smart00444   1 VLWLYKDPDGEIQGPFTASQMSQWYQAGYFPDSLQIKRLNEPPYETLGDLDRLLGL 56
tolA_full TIGR02794
TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the ...
 414-554 7.32e-04

TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the outer membrane complex of TolB and OprL (also called Pal). Most of the length of the protein consists of low-complexity sequence that may differ in both length and composition from one species to another, complicating efforts to discriminate TolA (the most divergent gene in the tol-pal system) from paralogs such as TonB. Selection of members of the seed alignment and criteria for setting scoring cutoffs are based largely conserved operon struction. //The Tol-Pal complex is required for maintaining outer membrane integrity. Also involved in transport (uptake) of colicins and filamentous DNA, and implicated in pathogenesis. Transport is energized by the proton motive force. TolA is an inner membrane protein that interacts with periplasmic TolB and with outer membrane porins ompC, phoE and lamB. [Transport and binding proteins, Other, Cellular processes, Pathogenesis]


Pssm-ID: 274303 [Multi-domain]  Cd Length: 346  Bit Score: 42.53  E-value: 7.32e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238031132  414 QQEELTKAKLRRQAEEARLQESLRLQRLKEQEKSKNEVSTSQKASDIAPWANTKVsgpplslRQIQELEAKQLQERKKK- 492
Cdd:TIGR02794  64 KKEQERQKKLEQQAEEAEKQRAAEQARQKELEQRAAAEKAAKQAEQAAKQAEEKQ-------KQAEEAKAKQAAEAKAKa 136

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 238031132  493 -QLNNVQNQPIAQRLSEGAASTSLPASATWAKTPvapvlATKSLTEIQKEQAEAQAQRLQSQA 554
Cdd:TIGR02794 137 eAEAERKAKEEAAKQAEEEAKAKAAAEAKKKAEE-----AKKKAEAEAKAKAEAEAKAKAEEA 194
tolA PRK09510
cell envelope integrity inner membrane protein TolA; Provisional
 410-547 6.87e-03

cell envelope integrity inner membrane protein TolA; Provisional


Pssm-ID: 236545 [Multi-domain]  Cd Length: 387  Bit Score: 39.40  E-value: 6.87e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238031132 410 LREIQQEELTKAKLRRQAEEARLQESLRLQRLKEQEKSKNEVSTSQKASDIAPWANTKVSGPPLSLRQIQELEAKQLQER 489
Cdd:PRK09510  80 QRKKKEQQQAEELQQKQAAEQERLKQLEKERLAAQEQKKQAEEAAKQAALKQKQAEEAAAKAAAAAKAKAEAEAKRAAAA 159

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 238031132 490 KKKQLNNVQNQPIAQRLSEGAASTSLPASATWAKTPVApvLATKSLTEIQKEQAEAQA 547
Cdd:PRK09510 160 AKKAAAEAKKKAEAEAAKKAAAEAKKKAEAEAAAKAAA--EAKKKAEAEAKKKAAAEA 215
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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