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Conserved domains on  [gi|257356690|emb|CBC18132|]
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unnamed protein product [Arabidopsis thaliana]

Protein Classification

alpha/beta fold hydrolase( domain architecture ID 11426811)

alpha/beta hydrolase family protein catalyzes the hydrolysis of substrates with different chemical composition or physicochemical properties using a nucleophile-His-acid catalytic triad

PubMed:  1409539|12369917

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
 60-309 2.93e-36

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


:

Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 129.74  E-value: 2.93e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257356690  60 PTKPVLLFIHGFAAeGIVTWQFQVGSLAKKYSVYIPDLLFFGGSYSDNADRSPAFQAHCLVKSLRILGIEKFTLVGFSYG 139
Cdd:COG0596   21 PDGPPVVLLHGLPG-SSYEWRPLIPALAAGYRVIAPDLRGHGRSDKPAGGYTLDDLADDLAALLDALGLERVVLVGHSMG 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257356690 140 GMVAFKIAEEYPEMVQAMVVSGSILAmtdtisesnlnqlgfkssadlllptsvkglktlftlAVHKPMWFPKRLFKDFIE 219
Cdd:COG0596  100 GMVALELAARHPERVAGLVLVDEVLA------------------------------------ALAEPLRRPGLAPEALAA 143

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257356690 220 VMITNRkeRAELLEALvisnKDVTIPrfqqkIHLLWGESDQIFNLEFAKSMKEQLgENATMESIKKAGHLAHLERPCVYN 299
Cdd:COG0596  144 LLRALA--RTDLRERL----ARITVP-----TLVIWGEKDPIVPPALARRLAELL-PNAELVVLPGAGHFPPLEQPEAFA 211

                        250
                 ....*....|
gi 257356690 300 RRLKKFLASV 309
Cdd:COG0596  212 AALRDFLARL 221
 
Name Accession Description Interval E-value
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
 60-309 2.93e-36

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 129.74  E-value: 2.93e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257356690  60 PTKPVLLFIHGFAAeGIVTWQFQVGSLAKKYSVYIPDLLFFGGSYSDNADRSPAFQAHCLVKSLRILGIEKFTLVGFSYG 139
Cdd:COG0596   21 PDGPPVVLLHGLPG-SSYEWRPLIPALAAGYRVIAPDLRGHGRSDKPAGGYTLDDLADDLAALLDALGLERVVLVGHSMG 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257356690 140 GMVAFKIAEEYPEMVQAMVVSGSILAmtdtisesnlnqlgfkssadlllptsvkglktlftlAVHKPMWFPKRLFKDFIE 219
Cdd:COG0596  100 GMVALELAARHPERVAGLVLVDEVLA------------------------------------ALAEPLRRPGLAPEALAA 143

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257356690 220 VMITNRkeRAELLEALvisnKDVTIPrfqqkIHLLWGESDQIFNLEFAKSMKEQLgENATMESIKKAGHLAHLERPCVYN 299
Cdd:COG0596  144 LLRALA--RTDLRERL----ARITVP-----TLVIWGEKDPIVPPALARRLAELL-PNAELVVLPGAGHFPPLEQPEAFA 211

                        250
                 ....*....|
gi 257356690 300 RRLKKFLASV 309
Cdd:COG0596  212 AALRDFLARL 221
Abhydrolase_1 pfam00561
alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.
 63-295 9.48e-23

alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.


Pssm-ID: 395444 [Multi-domain]  Cd Length: 245  Bit Score: 94.49  E-value: 9.48e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257356690   63 PVLLFIHGFAAeGIVTWQFQVGSLAKK-YSVYIPDLLFFGGS--YSDNADRSPAFQAHCLVKSLRILGIEKFTLVGFSYG 139
Cdd:pfam00561   1 PPVLLLHGLPG-SSDLWRKLAPALARDgFRVIALDLRGFGKSsrPKAQDDYRTDDLAEDLEYILEALGLEKVNLVGHSMG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257356690  140 GMVAFKIAEEYPEMVQAMVVSGSILAMTDTISES---NLNQLGFKSSADLLLPTSVKGLKTLFTLAVHKPMWFPKRLFKD 216
Cdd:pfam00561  80 GLIALAYAAKYPDRVKALVLLGALDPPHELDEADrfiLALFPGFFDGFVADFAPNPLGRLVAKLLALLLLRLRLLKALPL 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257356690  217 FI------EVMITNRKERAELLEALVISNKDV--TIPRFQQKIHLLWGESDQIFNLEFAKSMKEQLgENATMESIKKAGH 288
Cdd:pfam00561 160 LNkrfpsgDYALAKSLVTGALLFIETWSTELRakFLGRLDEPTLIIWGDQDPLVPPQALEKLAQLF-PNARLVVIPDAGH 238


                  ....*..
gi 257356690  289 LAHLERP 295
Cdd:pfam00561 239 FAFLEGP 245
PRK14875 PRK14875
acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional
 63-309 5.95e-16

acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional


Pssm-ID: 184875 [Multi-domain]  Cd Length: 371  Bit Score: 77.29  E-value: 5.95e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257356690  63 PVLLfIHGFAAEgIVTWQFQVGSLAKKYSVYIPDLLFFGGSYSDNADRSPAFQAHCLVKSLRILGIEKFTLVGFSYGGMV 142
Cdd:PRK14875 133 PVVL-IHGFGGD-LNNWLFNHAALAAGRPVIALDLPGHGASSKAVGAGSLDELAAAVLAFLDALGIERAHLVGHSMGGAV 210

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257356690 143 AFKIAEEYPEMVQAMVVSGSIlAMTDTISESNLNqlGFKSSAdlllptSVKGLKTLFTLAVHKpmwfPKRLFKDFIEVMI 222
Cdd:PRK14875 211 ALRLAARAPQRVASLTLIAPA-GLGPEINGDYID--GFVAAE------SRRELKPVLELLFAD----PALVTRQMVEDLL 277

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257356690 223 tnRKERAEL----LEALVISN------KDVTIPR---FQQKIHLLWGESDQIFNLEFAksmkEQLGENATMESIKKAGHL 289
Cdd:PRK14875 278 --KYKRLDGvddaLRALADALfaggrqRVDLRDRlasLAIPVLVIWGEQDRIIPAAHA----QGLPDGVAVHVLPGAGHM 351

                        250       260
                 ....*....|....*....|
gi 257356690 290 AHLERPCVYNRRLKKFLASV 309
Cdd:PRK14875 352 PQMEAAADVNRLLAEFLGKA 371
menH_SHCHC TIGR03695
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase; This protein catalyzes the ...
 61-306 6.45e-16

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase; This protein catalyzes the formation of SHCHC, or (1 R,6 R)-2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate, by elmination of pyruvate from 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC). Note that SHCHC synthase activity previously was attributed to MenD, which in fact is SEPHCHC synthase. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 274729 [Multi-domain]  Cd Length: 252  Bit Score: 75.72  E-value: 6.45e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257356690   61 TKPVLLFIHGFAAEGiVTWQFQVGSLAKKYSVYIPDLLFFGGSYSDNADRSPAFQAHC---LVKSLRILGIEKFTLVGFS 137
Cdd:TIGR03695   1 AKPVLVFLHGFLGSG-ADWQALIEALGPHFRCLAIDLPGHGSSQSPSDIERYDFEEAAqllLATLLDQLGIEPFFLVGYS 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257356690  138 YGGMVAFKIAEEYPEMVQAMVVSGSILAMTDtiseSNLNQLGFKSSADLLLPTSVKGLKTLFTlavhkpMWFPKRLFKD- 216
Cdd:TIGR03695  80 MGGRIALYYALQYPERVQGLILESGSPGLQT----EEERAARRQNDEQLAQRFEQEGLEAFLD------DWYQQPLFASq 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257356690  217 -----FIEVMItnRKER--------AELLEALVISN--------KDVTIPrfqqkIHLLWGESDQIFnLEFAKSMKEQLg 275
Cdd:TIGR03695 150 knlppEQRQAL--RAERlannpeglAKMLRATGLGKqpslwpklQALKIP-----VLYLCGERDEKF-VQIAKEMQKLI- 220

                         250       260       270
                  ....*....|....*....|....*....|.
gi 257356690  276 ENATMESIKKAGHLAHLERPCVYNRRLKKFL 306
Cdd:TIGR03695 221 PNLTLHIIPNAGHNIHLENPEAFAKILLAFL 251
 
Name Accession Description Interval E-value
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
 60-309 2.93e-36

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 129.74  E-value: 2.93e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257356690  60 PTKPVLLFIHGFAAeGIVTWQFQVGSLAKKYSVYIPDLLFFGGSYSDNADRSPAFQAHCLVKSLRILGIEKFTLVGFSYG 139
Cdd:COG0596   21 PDGPPVVLLHGLPG-SSYEWRPLIPALAAGYRVIAPDLRGHGRSDKPAGGYTLDDLADDLAALLDALGLERVVLVGHSMG 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257356690 140 GMVAFKIAEEYPEMVQAMVVSGSILAmtdtisesnlnqlgfkssadlllptsvkglktlftlAVHKPMWFPKRLFKDFIE 219
Cdd:COG0596  100 GMVALELAARHPERVAGLVLVDEVLA------------------------------------ALAEPLRRPGLAPEALAA 143

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257356690 220 VMITNRkeRAELLEALvisnKDVTIPrfqqkIHLLWGESDQIFNLEFAKSMKEQLgENATMESIKKAGHLAHLERPCVYN 299
Cdd:COG0596  144 LLRALA--RTDLRERL----ARITVP-----TLVIWGEKDPIVPPALARRLAELL-PNAELVVLPGAGHFPPLEQPEAFA 211

                        250
                 ....*....|
gi 257356690 300 RRLKKFLASV 309
Cdd:COG0596  212 AALRDFLARL 221
Abhydrolase_1 pfam00561
alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.
 63-295 9.48e-23

alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.


Pssm-ID: 395444 [Multi-domain]  Cd Length: 245  Bit Score: 94.49  E-value: 9.48e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257356690   63 PVLLFIHGFAAeGIVTWQFQVGSLAKK-YSVYIPDLLFFGGS--YSDNADRSPAFQAHCLVKSLRILGIEKFTLVGFSYG 139
Cdd:pfam00561   1 PPVLLLHGLPG-SSDLWRKLAPALARDgFRVIALDLRGFGKSsrPKAQDDYRTDDLAEDLEYILEALGLEKVNLVGHSMG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257356690  140 GMVAFKIAEEYPEMVQAMVVSGSILAMTDTISES---NLNQLGFKSSADLLLPTSVKGLKTLFTLAVHKPMWFPKRLFKD 216
Cdd:pfam00561  80 GLIALAYAAKYPDRVKALVLLGALDPPHELDEADrfiLALFPGFFDGFVADFAPNPLGRLVAKLLALLLLRLRLLKALPL 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257356690  217 FI------EVMITNRKERAELLEALVISNKDV--TIPRFQQKIHLLWGESDQIFNLEFAKSMKEQLgENATMESIKKAGH 288
Cdd:pfam00561 160 LNkrfpsgDYALAKSLVTGALLFIETWSTELRakFLGRLDEPTLIIWGDQDPLVPPQALEKLAQLF-PNARLVVIPDAGH 238


                  ....*..
gi 257356690  289 LAHLERP 295
Cdd:pfam00561 239 FAFLEGP 245
PRK14875 PRK14875
acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional
 63-309 5.95e-16

acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional


Pssm-ID: 184875 [Multi-domain]  Cd Length: 371  Bit Score: 77.29  E-value: 5.95e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257356690  63 PVLLfIHGFAAEgIVTWQFQVGSLAKKYSVYIPDLLFFGGSYSDNADRSPAFQAHCLVKSLRILGIEKFTLVGFSYGGMV 142
Cdd:PRK14875 133 PVVL-IHGFGGD-LNNWLFNHAALAAGRPVIALDLPGHGASSKAVGAGSLDELAAAVLAFLDALGIERAHLVGHSMGGAV 210

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257356690 143 AFKIAEEYPEMVQAMVVSGSIlAMTDTISESNLNqlGFKSSAdlllptSVKGLKTLFTLAVHKpmwfPKRLFKDFIEVMI 222
Cdd:PRK14875 211 ALRLAARAPQRVASLTLIAPA-GLGPEINGDYID--GFVAAE------SRRELKPVLELLFAD----PALVTRQMVEDLL 277

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257356690 223 tnRKERAEL----LEALVISN------KDVTIPR---FQQKIHLLWGESDQIFNLEFAksmkEQLGENATMESIKKAGHL 289
Cdd:PRK14875 278 --KYKRLDGvddaLRALADALfaggrqRVDLRDRlasLAIPVLVIWGEQDRIIPAAHA----QGLPDGVAVHVLPGAGHM 351

                        250       260
                 ....*....|....*....|
gi 257356690 290 AHLERPCVYNRRLKKFLASV 309
Cdd:PRK14875 352 PQMEAAADVNRLLAEFLGKA 371
menH_SHCHC TIGR03695
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase; This protein catalyzes the ...
 61-306 6.45e-16

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase; This protein catalyzes the formation of SHCHC, or (1 R,6 R)-2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate, by elmination of pyruvate from 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC). Note that SHCHC synthase activity previously was attributed to MenD, which in fact is SEPHCHC synthase. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 274729 [Multi-domain]  Cd Length: 252  Bit Score: 75.72  E-value: 6.45e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257356690   61 TKPVLLFIHGFAAEGiVTWQFQVGSLAKKYSVYIPDLLFFGGSYSDNADRSPAFQAHC---LVKSLRILGIEKFTLVGFS 137
Cdd:TIGR03695   1 AKPVLVFLHGFLGSG-ADWQALIEALGPHFRCLAIDLPGHGSSQSPSDIERYDFEEAAqllLATLLDQLGIEPFFLVGYS 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257356690  138 YGGMVAFKIAEEYPEMVQAMVVSGSILAMTDtiseSNLNQLGFKSSADLLLPTSVKGLKTLFTlavhkpMWFPKRLFKD- 216
Cdd:TIGR03695  80 MGGRIALYYALQYPERVQGLILESGSPGLQT----EEERAARRQNDEQLAQRFEQEGLEAFLD------DWYQQPLFASq 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257356690  217 -----FIEVMItnRKER--------AELLEALVISN--------KDVTIPrfqqkIHLLWGESDQIFnLEFAKSMKEQLg 275
Cdd:TIGR03695 150 knlppEQRQAL--RAERlannpeglAKMLRATGLGKqpslwpklQALKIP-----VLYLCGERDEKF-VQIAKEMQKLI- 220

                         250       260       270
                  ....*....|....*....|....*....|.
gi 257356690  276 ENATMESIKKAGHLAHLERPCVYNRRLKKFL 306
Cdd:TIGR03695 221 PNLTLHIIPNAGHNIHLENPEAFAKILLAFL 251
PldB COG2267
Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];
56-294 2.77e-14

Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];


Pssm-ID: 441868 [Multi-domain]  Cd Length: 221  Bit Score: 70.80  E-value: 2.77e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257356690  56 EPQKPTKPVLLFIHGFAaEGIVTWQFQVGSLAKK-YSVYIPDLLFFGGSYSDNADRsPAFQ-----AHCLVKSLRILGIE 129
Cdd:COG2267   22 RPAGSPRGTVVLVHGLG-EHSGRYAELAEALAAAgYAVLAFDLRGHGRSDGPRGHV-DSFDdyvddLRAALDALRARPGL 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257356690 130 KFTLVGFSYGGMVAFKIAEEYPEMVQAMVVSGSILAmtdtisesnlnqlgfkssADLLLPTSVKGLKTLftlavhkpmwf 209
Cdd:COG2267  100 PVVLLGHSMGGLIALLYAARYPDRVAGLVLLAPAYR------------------ADPLLGPSARWLRAL----------- 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257356690 210 pkrlfkdfievmitnrkeraELLEALvisnKDVTIPrfqqkIHLLWGESDQIFNLEFAKSMKEQLGENATMESIKKAGHL 289
Cdd:COG2267  151 --------------------RLAEAL----ARIDVP-----VLVLHGGADRVVPPEAARRLAARLSPDVELVLLPGARHE 201


                 ....*
gi 257356690 290 AHLER 294
Cdd:COG2267  202 LLNEP 206
PLN02578 PLN02578
hydrolase
 63-308 3.21e-11

hydrolase


Pssm-ID: 215315 [Multi-domain]  Cd Length: 354  Bit Score: 63.32  E-value: 3.21e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257356690  63 PVLLfIHGFAAEgIVTWQFQVGSLAKKYSVYIPDLLFFGgsYSDNA--DRSPAFQAHCLVKSLRILGIEKFTLVGFSYGG 140
Cdd:PLN02578  88 PIVL-IHGFGAS-AFHWRYNIPELAKKYKVYALDLLGFG--WSDKAliEYDAMVWRDQVADFVKEVVKEPAVLVGNSLGG 163

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257356690 141 MVAFKIAEEYPEMVQAMVVSGSILAMTDTISESNLNQLGFKSSADLLLptsVKGLKTLFT----LAVHKPMWFPKRLFKD 216
Cdd:PLN02578 164 FTALSTAVGYPELVAGVALLNSAGQFGSESREKEEAIVVEETVLTRFV---VKPLKEWFQrvvlGFLFWQAKQPSRIESV 240

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257356690 217 FIEVMITNRKERAELLEALVISNKDVT--------IPRF--QQK--------------IHLLWGESDQIFNLEFAKSMKE 272
Cdd:PLN02578 241 LKSVYKDKSNVDDYLVESITEPAADPNagevyyrlMSRFlfNQSrytldsllsklscpLLLLWGDLDPWVGPAKAEKIKA 320

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 257356690 273 qLGENATMESIkKAGHLAHLERPCVYNRRLKKFLAS 308
Cdd:PLN02578 321 -FYPDTTLVNL-QAGHCPHDEVPEQVNKALLEWLSS 354
Abhydrolase_6 pfam12697
Alpha/beta hydrolase family; This family contains alpha/beta hydrolase enzymes of diverse ...
 65-293 3.80e-11

Alpha/beta hydrolase family; This family contains alpha/beta hydrolase enzymes of diverse specificity.


Pssm-ID: 463673 [Multi-domain]  Cd Length: 211  Bit Score: 61.72  E-value: 3.80e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257356690   65 LLFIHGFaaeGIVTWQFQvGSLAKKYSVYIPDLLFFGGSYSDNADRSPAFQAHCLVKSLRILGieKFTLVGFSYGGMVAF 144
Cdd:pfam12697   1 VVLVHGA---GLSAAPLA-ALLAAGVAVLAPDLPGHGSSSPPPLDLADLADLAALLDELGAAR--PVVLVGHSLGGAVAL 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257356690  145 kiaeeypEMVQAMVVSGSILAmtdtiSESNLNQLGFKSSADLLLPTSVKGLKTLFTLAVHKPMWFPKRLFKDFIEVMITN 224
Cdd:pfam12697  75 -------AAAAAALVVGVLVA-----PLAAPPGLLAALLALLARLGAALAAPAWLAAESLARGFLDDLPADAEWAAALAR 142

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 257356690  225 RKERAELLEALVISNkdvtIPRFQQKIHLLWGEsDQIFNLEFAKSMKEQlgENATMESIKKAGHLAHLE 293
Cdd:pfam12697 143 LAALLAALALLPLAA----WRDLPVPVLVLAEE-DRLVPELAQRLLAAL--AGARLVVLPGAGHLPLDD 204
PLN02894 PLN02894
hydrolase, alpha/beta fold family protein
 14-162 1.45e-08

hydrolase, alpha/beta fold family protein


Pssm-ID: 215484 [Multi-domain]  Cd Length: 402  Bit Score: 55.30  E-value: 1.45e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257356690  14 RLMKLAGViPYTVEL------EPGTKMNFWipketlkkTKKSDK----NFAVEPQKPTKPVLLFIHGFAA-EGIVTWQFQ 82
Cdd:PLN02894  56 RLLSLVKT-PYVQEQvnigsgPPGSKVRWF--------RSASNEprfiNTVTFDSKEDAPTLVMVHGYGAsQGFFFRNFD 126

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257356690  83 vgSLAKKYSVYIPDLLFFGGS-----YSDNADRSPAFQAHCLVKSLRILGIEKFTLVGFSYGGMVAFKIAEEYPEMVQAM 157
Cdd:PLN02894 127 --ALASRFRVIAIDQLGWGGSsrpdfTCKSTEETEAWFIDSFEEWRKAKNLSNFILLGHSFGGYVAAKYALKHPEHVQHL 204


                 ....*
gi 257356690 158 VVSGS 162
Cdd:PLN02894 205 ILVGP 209
DAP2 COG1506
Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];
57-174 6.98e-08

Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];


Pssm-ID: 441115 [Multi-domain]  Cd Length: 234  Bit Score: 52.33  E-value: 6.98e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257356690  57 PQKPTKPVLLFIHGFAAEGIVTWQFQVGSLAKK-YSVYIPDLLFFGGS-----YSDNADRSPAFQAhclVKSLRILGIEK 130
Cdd:COG1506   18 ADGKKYPVVVYVHGGPGSRDDSFLPLAQALASRgYAVLAPDYRGYGESagdwgGDEVDDVLAAIDY---LAARPYVDPDR 94

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 257356690 131 FTLVGFSYGGMVAFKIAEEYPEMVQAMVVSGSILAMTDTISESN 174
Cdd:COG1506   95 IGIYGHSYGGYMALLAAARHPDRFKAAVALAGVSDLRSYYGTTR 138
YvaK COG1647
Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism];
59-309 7.09e-08

Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 441253 [Multi-domain]  Cd Length: 246  Bit Score: 52.64  E-value: 7.09e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257356690  59 KPTKPVLLFIHGFAAegivTwQFQVGSLAKK-----YSVYIPDLLFFGGSYSDNADRSPAFQAHCLVKSLRIL--GIEKF 131
Cdd:COG1647   12 EGGRKGVLLLHGFTG----S-PAEMRPLAEAlakagYTVYAPRLPGHGTSPEDLLKTTWEDWLEDVEEAYEILkaGYDKV 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257356690 132 TLVGFSYGGMVAFKIAEEYPEMVQAMVVSGSIlamtdTISESNLNQLGFKSSADLLLPTSVKGLKTlFTLAVHKPMWFPK 211
Cdd:COG1647   87 IVIGLSMGGLLALLLAARYPDVAGLVLLSPAL-----KIDDPSAPLLPLLKYLARSLRGIGSDIED-PEVAEYAYDRTPL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257356690 212 RLFKDFIEVMitnRKERAELlealvisnKDVTIPrfqqkIHLLWGESDQIFNLEFAKSMKEQLG-ENATMESIKKAGHLA 290
Cdd:COG1647  161 RALAELQRLI---REVRRDL--------PKITAP-----TLIIQSRKDEVVPPESARYIYERLGsPDKELVWLEDSGHVI 224

                        250       260
                 ....*....|....*....|.
gi 257356690 291 HL--ERPCVYnRRLKKFLASV 309
Cdd:COG1647  225 TLdkDREEVA-EEILDFLERL 244
EstA COG1075
Triacylglycerol esterase/lipase EstA, alpha/beta hydrolase fold [Lipid transport and ...
 59-143 1.41e-06

Triacylglycerol esterase/lipase EstA, alpha/beta hydrolase fold [Lipid transport and metabolism];


Pssm-ID: 440693 [Multi-domain]  Cd Length: 106  Bit Score: 45.98  E-value: 1.41e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257356690  59 KPTKPVLLFIHGFAAEGIvTWQFQVGSLAKK-YSVYIPDLLFFGGSYSDNADRspafQAHCLVKSLRILGIEKFTLVGFS 137
Cdd:COG1075    2 AATRYPVVLVHGLGGSAA-SWAPLAPRLRAAgYPVYALNYPSTNGSIEDSAEQ----LAAFVDAVLAATGAEKVDLVGHS 76


                 ....*.
gi 257356690 138 YGGMVA 143
Cdd:COG1075   77 MGGLVA 82
PLN02679 PLN02679
hydrolase, alpha/beta fold family protein
 58-311 1.63e-06

hydrolase, alpha/beta fold family protein


Pssm-ID: 178283 [Multi-domain]  Cd Length: 360  Bit Score: 49.07  E-value: 1.63e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257356690  58 QKPTKPVLLFIHGFAAEgIVTWQFQVGSLAKKYSVYIPDLLFFGGSysdnaDRSPAFQ------AHCLVKSLRILgIEKF 131
Cdd:PLN02679  84 VTSSGPPVLLVHGFGAS-IPHWRRNIGVLAKNYTVYAIDLLGFGAS-----DKPPGFSytmetwAELILDFLEEV-VQKP 156

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257356690 132 T-LVGFSYGGMvAFKIA--EEYPEMVQAMVVSGSILAMTDtisesnlnqlgfKSSAD-----LLLPTsvkglktlftlav 203
Cdd:PLN02679 157 TvLIGNSVGSL-ACVIAasESTRDLVRGLVLLNCAGGMNN------------KAVVDdwrikLLLPL------------- 210

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257356690 204 hkpMWFPKRLFKD-FIEVMITNR-KERAELLEAL--VISNKD--------------------------VT---------- 243
Cdd:PLN02679 211 ---LWLIDFLLKQrGIASALFNRvKQRDNLKNILlsVYGNKEavddelveiirgpaddegaldafvsiVTgppgpnpikl 287

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 257356690 244 IPRFQQKIHLLWGESDQIFNLE-----FAKSMKEQLgENATMESIKKAGHLAHLERPCVYNRRLKKFLASVYS 311
Cdd:PLN02679 288 IPRISLPILVLWGDQDPFTPLDgpvgkYFSSLPSQL-PNVTLYVLEGVGHCPHDDRPDLVHEKLLPWLAQLPS 359
PLN02980 PLN02980
2-oxoglutarate decarboxylase/ hydro-lyase/ magnesium ion binding / thiamin pyrophosphate ...
 64-310 1.85e-05

2-oxoglutarate decarboxylase/ hydro-lyase/ magnesium ion binding / thiamin pyrophosphate binding


Pssm-ID: 215530 [Multi-domain]  Cd Length: 1655  Bit Score: 46.39  E-value: 1.85e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257356690   64 VLLFIHGFAAEG---IVTWQFQVGSlAKKYSVYIPDllfFGGS----YSDNADRSPAFQ----AHCLVKSLRILGIEKFT 132
Cdd:PLN02980 1373 VVLFLHGFLGTGedwIPIMKAISGS-ARCISIDLPG---HGGSkiqnHAKETQTEPTLSvelvADLLYKLIEHITPGKVT 1448

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257356690  133 LVGFSYGGMVAFKIAEEYPEMVQ-AMVVSGSIlAMTDTISEsNLNQLGFKSSADLLLptsVKGLKTLFTLAVHKPMWFPK 211
Cdd:PLN02980 1449 LVGYSMGARIALYMALRFSDKIEgAVIISGSP-GLKDEVAR-KIRSAKDDSRARMLI---DHGLEIFLENWYSGELWKSL 1523

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257356690  212 RLFKDFIEVMIT-----NRKERAELLEALVISN--------KDVTIPrfqqkIHLLWGESDQIFNlEFAKSMKEQLGENA 278
Cdd:PLN02980 1524 RNHPHFNKIVASrllhkDVPSLAKLLSDLSIGRqpslwedlKQCDTP-----LLLVVGEKDVKFK-QIAQKMYREIGKSK 1597

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 257356690  279 T-----------MESIKKAGHLAHLERPCVYNRRLKKFLASVY 310
Cdd:PLN02980 1598 EsgndkgkeiieIVEIPNCGHAVHLENPLPVIRALRKFLTRLH 1640
PRK11126 PRK11126
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase; Provisional
 61-308 6.08e-05

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase; Provisional


Pssm-ID: 236855 [Multi-domain]  Cd Length: 242  Bit Score: 43.67  E-value: 6.08e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257356690  61 TKPVLLFIHGF---AAEgivtWQfQVGSLAKKYSVYIPDLLFFGGSysdnADRSPAFQAHC---LVKSLRILGIEKFTLV 134
Cdd:PRK11126   1 GLPWLVFLHGLlgsGQD----WQ-PVGEALPDYPRLYIDLPGHGGS----AAISVDGFADVsrlLSQTLQSYNILPYWLV 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257356690 135 GFSYGGMVAFKIA--EEYPEMVQAMVVSGSI-LA-------------------MTDTISE-----------SNLN----- 176
Cdd:PRK11126  72 GYSLGGRIAMYYAcqGLAGGLCGLIVEGGNPgLQnaeerqarwqndrqwaqrfRQEPLEQvladwyqqpvfASLNaeqrq 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257356690 177 QLGFKSS-------ADLLLPTSvkglktlftLAvHKPmwfpkrlfkdfievmitnrkeraELLEALvisnKDVTIPrfqq 249
Cdd:PRK11126 152 QLVAKRSnnngaavAAMLEATS---------LA-KQP-----------------------DLRPAL----QALTFP---- 190

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 257356690 250 kIHLLWGESDQIFnlefaKSMKEQLGenATMESIKKAGHLAHLERPCVYNRRLKKFLAS 308
Cdd:PRK11126 191 -FYYLCGERDSKF-----QALAQQLA--LPLHVIPNAGHNAHRENPAAFAASLAQILRL 241
PRK08775 PRK08775
homoserine O-succinyltransferase;
99-159 2.22e-04

homoserine O-succinyltransferase;


Pssm-ID: 181553 [Multi-domain]  Cd Length: 343  Bit Score: 42.47  E-value: 2.22e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 257356690  99 FFGGSYSDNADRSPAFQAHCLVKSLRILGIEK-FTLVGFSYGGMVAFKIAEEYPEMVQAMVV 159
Cdd:PRK08775 107 FIGADGSLDVPIDTADQADAIALLLDALGIARlHAFVGYSYGALVGLQFASRHPARVRTLVV 168
Hydrolase_4 pfam12146
Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is ...
 60-161 1.27e-03

Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is approximately 110 amino acids in length. It is found in association with pfam00561. The majority of the members in this family carry the exopeptidase active-site residues of Ser-122, Asp-239 and His-269 as in UniProtKB:Q7ZWC2.


Pssm-ID: 463473 [Multi-domain]  Cd Length: 238  Bit Score: 39.51  E-value: 1.27e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257356690   60 PTKPVLLFIHGFAaEGIVTWQFQVGSLAKK-YSVYIPDLLFFGGSysDNAD-RSPAFQ-----AHCLVKSLR-ILGIEKF 131
Cdd:pfam12146   2 EPRAVVVLVHGLG-EHSGRYAHLADALAAQgFAVYAYDHRGHGRS--DGKRgHVPSFDdyvddLDTFVDKIReEHPGLPL 78

                          90       100       110
                  ....*....|....*....|....*....|
gi 257356690  132 TLVGFSYGGMVAFKIAEEYPEMVQAMVVSG 161
Cdd:pfam12146  79 FLLGHSMGGLIAALYALRYPDKVDGLILSA 108
PRK10566 PRK10566
esterase; Provisional
 63-161 1.60e-03

esterase; Provisional


Pssm-ID: 182555 [Multi-domain]  Cd Length: 249  Bit Score: 39.20  E-value: 1.60e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257356690  63 PVLLFIHGFAAEGIVTWQFQVgSLAKK-YSVYIPDLLFFGGSYSDNADRS---------------PAFQAHCLVKSLrIL 126
Cdd:PRK10566  28 PTVFFYHGFTSSKLVYSYFAV-ALAQAgFRVIMPDAPMHGARFSGDEARRlnhfwqillqnmqefPTLRAAIREEGW-LL 105

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 257356690 127 GiEKFTLVGFSYGGMVAFKIAEEYPEM--VQAMVVSG 161
Cdd:PRK10566 106 D-DRLAVGGASMGGMTALGIMARHPWVkcVASLMGSG 141
DLH COG0412
Dienelactone hydrolase [Secondary metabolites biosynthesis, transport and catabolism];
55-160 2.44e-03

Dienelactone hydrolase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 440181 [Multi-domain]  Cd Length: 226  Bit Score: 38.79  E-value: 2.44e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257356690  55 VEPQKPTK-PVLLFIHGFAaeGIVTWQFQVGS-LAKK-YSVYIPDLLFFGGSYSDNADRSPAFQAHCL------------ 119
Cdd:COG0412   21 ARPAGGGPrPGVVVLHEIF--GLNPHIRDVARrLAAAgYVVLAPDLYGRGGPGDDPDEARALMGALDPellaadlraald 98

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 257356690 120 -VKSLRILGIEKFTLVGFSYGGMVAFKIAEEYPEmVQAmVVS 160
Cdd:COG0412   99 wLKAQPEVDAGRVGVVGFCFGGGLALLAAARGPD-LAA-AVS 138
PRK10349 PRK10349
pimeloyl-ACP methyl ester esterase BioH;
65-162 2.62e-03

pimeloyl-ACP methyl ester esterase BioH;


Pssm-ID: 137836 [Multi-domain]  Cd Length: 256  Bit Score: 38.85  E-value: 2.62e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257356690  65 LLFIHGFAAEGIVtWQFQVGSLAKKYSVYIPDLLFFGgsysdnadRSPAFQAHCLVKSLRIL---GIEKFTLVGFSYGGM 141
Cdd:PRK10349  16 LVLLHGWGLNAEV-WRCIDEELSSHFTLHLVDLPGFG--------RSRGFGALSLADMAEAVlqqAPDKAIWLGWSLGGL 86

                         90       100
                 ....*....|....*....|.
gi 257356690 142 VAFKIAEEYPEMVQAMVVSGS 162
Cdd:PRK10349  87 VASQIALTHPERVQALVTVAS 107
homoserO_Ac_trn TIGR01392
homoserine O-acetyltransferase; This family describes homoserine-O-acetyltransferase, an ...
 123-159 4.61e-03

homoserine O-acetyltransferase; This family describes homoserine-O-acetyltransferase, an enzyme of methionine biosynthesis. This model has been rebuilt to identify sequences more broadly, including a number of sequences suggested to be homoserine O-acetyltransferase based on proximity to other Met biosynthesis genes. [Amino acid biosynthesis, Aspartate family]


Pssm-ID: 273596 [Multi-domain]  Cd Length: 351  Bit Score: 38.44  E-value: 4.61e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 257356690  123 LRILGIEKFTLV-GFSYGGMVAFKIAEEYPEMVQAMVV 159
Cdd:TIGR01392 120 LDHLGIEQIAAVvGGSMGGMQALEWAIDYPERVRAIVV 157
MET2 COG2021
Homoserine O-acetyltransferase [Amino acid transport and metabolism]; Homoserine ...
 123-159 4.80e-03

Homoserine O-acetyltransferase [Amino acid transport and metabolism]; Homoserine O-acetyltransferase is part of the Pathway/BioSystem: Methionine biosynthesis


Pssm-ID: 441624 [Multi-domain]  Cd Length: 355  Bit Score: 38.15  E-value: 4.80e-03
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 257356690 123 LRILGIEKF-TLVGFSYGGMVAFKIAEEYPEMVQAMVV 159
Cdd:COG2021  121 LDHLGIERLaAVIGGSMGGMQALEWAVSYPDRVRRAIV 158
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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