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Conserved domains on  [gi|257743172|emb|CBC51716|]
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unnamed protein product [Arabidopsis thaliana]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RecA-like_spastin cd19524
ATPase domain of spastin; Spastin is an ATP-dependent microtubule-severing protein involved in ...
 84-247 1.03e-104

ATPase domain of spastin; Spastin is an ATP-dependent microtubule-severing protein involved in microtubule dynamics; it specifically recognizes and cuts microtubules that are polyglutamylated. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


:

Pssm-ID: 410932 [Multi-domain]  Cd Length: 164  Bit Score: 304.47  E-value: 1.03e-104
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257743172  84 DVAGLNGAKQALLEMVILPAKRRDLFTGLRRPARGLLLFGPPGNGKTMLAKAVASESQATFFNVSASSLTSKWVGEAEKL 163
Cdd:cd19524    1 DIAGQDLAKQALQEMVILPSLRPELFTGLRAPARGLLLFGPPGNGKTMLAKAVAAESNATFFNISAASLTSKYVGEGEKL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257743172 164 VKTLFQVAISRQPSVIFMDEIDSIMSTRSTSENEASRRLKSEFLIQFDGVTSNPDDLVIIIGATNKPQELDDAVLRRLVK 243
Cdd:cd19524   81 VRALFAVARELQPSIIFIDEVDSLLSERSEGEHEASRRLKTEFLIEFDGVQSNGDDRVLVMGATNRPQELDDAVLRRFTK 160


                 ....
gi 257743172 244 RIYV 247
Cdd:cd19524  161 RVYV 164
AAA_lid_3 pfam17862
AAA+ lid domain; This entry represents the alpha helical AAA+ lid domain that is found to the ...
 274-309 3.90e-11

AAA+ lid domain; This entry represents the alpha helical AAA+ lid domain that is found to the C-terminus of AAA domains.


:

Pssm-ID: 465537 [Multi-domain]  Cd Length: 45  Bit Score: 57.55  E-value: 3.90e-11
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 257743172  274 DIDKIVKETEGYSGSDLQALCEEAAMMPIRELGANI 309
Cdd:pfam17862   3 DLEELAERTEGFSGADLEALCREAALAALRRGLEAV 38
Vps4_C super family cl07827
Vps4 C terminal oligomerization domain; This domain is found at the C terminal of ATPase ...
 312-352 9.35e-04

Vps4 C terminal oligomerization domain; This domain is found at the C terminal of ATPase proteins involved in vacuolar sorting. It forms an alpha helix structure and is required for oligomerization.


The actual alignment was detected with superfamily member pfam09336:

Pssm-ID: 462762 [Multi-domain]  Cd Length: 61  Bit Score: 37.09  E-value: 9.35e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 257743172  312 IQANKV--RSLRYDDFRKSMAVIRPSLSKSKWEELERWNSEFG 352
Cdd:pfam09336  19 IPSDKLlePPVTMKDFLKALKSSRPTVSKEDLEKYEEFTKEFG 61
 
Name Accession Description Interval E-value
RecA-like_spastin cd19524
ATPase domain of spastin; Spastin is an ATP-dependent microtubule-severing protein involved in ...
 84-247 1.03e-104

ATPase domain of spastin; Spastin is an ATP-dependent microtubule-severing protein involved in microtubule dynamics; it specifically recognizes and cuts microtubules that are polyglutamylated. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410932 [Multi-domain]  Cd Length: 164  Bit Score: 304.47  E-value: 1.03e-104
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257743172  84 DVAGLNGAKQALLEMVILPAKRRDLFTGLRRPARGLLLFGPPGNGKTMLAKAVASESQATFFNVSASSLTSKWVGEAEKL 163
Cdd:cd19524    1 DIAGQDLAKQALQEMVILPSLRPELFTGLRAPARGLLLFGPPGNGKTMLAKAVAAESNATFFNISAASLTSKYVGEGEKL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257743172 164 VKTLFQVAISRQPSVIFMDEIDSIMSTRSTSENEASRRLKSEFLIQFDGVTSNPDDLVIIIGATNKPQELDDAVLRRLVK 243
Cdd:cd19524   81 VRALFAVARELQPSIIFIDEVDSLLSERSEGEHEASRRLKTEFLIEFDGVQSNGDDRVLVMGATNRPQELDDAVLRRFTK 160


                 ....
gi 257743172 244 RIYV 247
Cdd:cd19524  161 RVYV 164
RPT1 COG1222
ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein ...
 34-340 3.84e-88

ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440835 [Multi-domain]  Cd Length: 326  Bit Score: 268.03  E-value: 3.84e-88
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257743172  34 ARGGVATPRNPKDAAASPKPVKES------GNVYDDKLVEMINTTIVDRSPSVKWDDVAGLNGAKQALLEMVILPAKRRD 107
Cdd:COG1222   23 ERLGVELALLLQPVKALELLEEAPalllndANLTQKRLGTPRGTAVPAESPDVTFDDIGGLDEQIEEIREAVELPLKNPE 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257743172 108 LFT--GLRRPaRGLLLFGPPGNGKTMLAKAVASESQATFFNVSASSLTSKWVGEAEKLVKTLFQVAISRQPSVIFMDEID 185
Cdd:COG1222  103 LFRkyGIEPP-KGVLLYGPPGTGKTLLAKAVAGELGAPFIRVRGSELVSKYIGEGARNVREVFELAREKAPSIIFIDEID 181

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257743172 186 SIMSTRS-TSENEASRRLKSEFLIQFDGVTSNPDdlVIIIGATNKPQELDDAVLR--RLVKRIYVPLPDSNVRKLLFKTK 262
Cdd:COG1222  182 AIAARRTdDGTSGEVQRTVNQLLAELDGFESRGD--VLIIAATNRPDLLDPALLRpgRFDRVIEVPLPDEEAREEILKIH 259

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 257743172 263 LKCQPhsLSDG-DIDKIVKETEGYSGSDLQALCEEAAMMPIRElganiltiqanKVRSLRYDDFRKSMAVIRPSLSKSK 340
Cdd:COG1222  260 LRDMP--LADDvDLDKLAKLTEGFSGADLKAIVTEAGMFAIRE-----------GRDTVTMEDLEKAIEKVKKKTETAT 325
cell_div_CdvC NF041006
cell division protein CdvC;
53-351 1.32e-78

cell division protein CdvC;


Pssm-ID: 468935 [Multi-domain]  Cd Length: 371  Bit Score: 245.41  E-value: 1.32e-78
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257743172  53 PVKESGNVYDDKLVEMInttIVDRSPSVKWDDVAGLNGAKQALLEMVILPAKRRDLFTgLRRPaRGLLLFGPPGNGKTML 132
Cdd:NF041006  76 PAEPAGPDVEKESDEEL---VVKEKPKVTFSDIVGLEDVKEALKEAIVYPSKRPDLFP-LGWP-RGILLYGPPGCGKTML 150

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257743172 133 AKAVASESQATFFNVSASSLTSKWVGEAEKLVKTLFQVA--ISRQ---PSVIFMDEIDSIMSTRStSENEASRRLKSEFL 207
Cdd:NF041006 151 AAAVANEIDSEFIHVDAASIMSKWLGEAEKNVAKIFKKAreKSKEegkPAIIFIDEIDALLGVYS-SEVGGEVRVRNQFL 229

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257743172 208 IQFDGVTSNPDDL-VIIIGATNKPQELDDAVLRRLVKRIYVPLPDSNVRKLLFK---TKLKCQPhslsDGDIDKIVKETE 283
Cdd:NF041006 230 KEMDGLQDKSENYhVYVIGATNKPWRLDEPFLRRFQKRIYIPLPDREQRLELLKyytSKIKLEN----DVDLDELAEMTE 305

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 257743172 284 GYSGSDLQALCEEAAMMPIRELGANiltiQANKVRSLRYDDFRKSMAVIRPSLSKSKWEELERWNSEF 351
Cdd:NF041006 306 GYTASDIRDIVQAAHMRVVKEMFEK----GLGEPRPITMEDFKEVLKIRKPSVNQEMLKAYEAWHEKF 369
CDC48 TIGR01243
AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two ...
 78-352 1.79e-65

AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two members each from three archaeal species. It also includes yeast CDC48 (cell division control protein 48) and the human ortholog, transitional endoplasmic reticulum ATPase (valosin-containing protein). These proteins in eukaryotes are involved in the budding and transfer of membrane from the transitional endoplasmic reticulum to the Golgi apparatus.


Pssm-ID: 273521 [Multi-domain]  Cd Length: 733  Bit Score: 220.16  E-value: 1.79e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257743172   78 PSVKWDDVAGLNGAKQALLEMVILPAKRRDLFTGLR-RPARGLLLFGPPGNGKTMLAKAVASESQATFFNVSASSLTSKW 156
Cdd:TIGR01243 448 PNVRWSDIGGLEEVKQELREAVEWPLKHPEIFEKMGiRPPKGVLLFGPPGTGKTLLAKAVATESGANFIAVRGPEILSKW 527

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257743172  157 VGEAEKLVKTLFQVAISRQPSVIFMDEIDSIMSTRSTSENEA-SRRLKSEFLIQFDGVTSNPDdlVIIIGATNKPQELDD 235
Cdd:TIGR01243 528 VGESEKAIREIFRKARQAAPAIIFFDEIDAIAPARGARFDTSvTDRIVNQLLTEMDGIQELSN--VVVIAATNRPDILDP 605

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257743172  236 AVLR--RLVKRIYVPLPDSNVRKLLFKTKLKCQPHSlSDGDIDKIVKETEGYSGSDLQALCEEAAMMPIRELGANIL--- 310
Cdd:TIGR01243 606 ALLRpgRFDRLILVPPPDEEARKEIFKIHTRSMPLA-EDVDLEELAEMTEGYTGADIEAVCREAAMAALRESIGSPAkek 684

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 257743172  311 ----TIQANKVRSLRYDDFRKSMAVIRPSLSKSKWEELERWNSEFG 352
Cdd:TIGR01243 685 levgEEEFLKDLKVEMRHFLEALKKVKPSVSKEDMLRYERLAKELK 730
PRK03992 PRK03992
proteasome-activating nucleotidase; Provisional
 74-304 1.27e-62

proteasome-activating nucleotidase; Provisional


Pssm-ID: 179699 [Multi-domain]  Cd Length: 389  Bit Score: 204.68  E-value: 1.27e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257743172  74 VDRSPSVKWDDVAGLNGAKQALLEMVILPAKRRDLFT--GLRrPARGLLLFGPPGNGKTMLAKAVASESQATFFNVSASS 151
Cdd:PRK03992 122 VIESPNVTYEDIGGLEEQIREVREAVELPLKKPELFEevGIE-PPKGVLLYGPPGTGKTLLAKAVAHETNATFIRVVGSE 200

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257743172 152 LTSKWVGEAEKLVKTLFQVAISRQPSVIFMDEIDSIMSTRSTSENEASR---RLKSEFLIQFDGVtsNPDDLVIIIGATN 228
Cdd:PRK03992 201 LVQKFIGEGARLVRELFELAREKAPSIIFIDEIDAIAAKRTDSGTSGDRevqRTLMQLLAEMDGF--DPRGNVKIIAATN 278

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 257743172 229 KPQELDDAVLR--RLVKRIYVPLPDSNVRKLLFKTKLKCQphSLSDG-DIDKIVKETEGYSGSDLQALCEEAAMMPIRE 304
Cdd:PRK03992 279 RIDILDPAILRpgRFDRIIEVPLPDEEGRLEILKIHTRKM--NLADDvDLEELAELTEGASGADLKAICTEAGMFAIRD 355
AAA pfam00004
ATPase family associated with various cellular activities (AAA); AAA family proteins often ...
 119-249 5.10e-53

ATPase family associated with various cellular activities (AAA); AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.


Pssm-ID: 459627 [Multi-domain]  Cd Length: 130  Bit Score: 171.24  E-value: 5.10e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257743172  119 LLLFGPPGNGKTMLAKAVASESQATFFNVSASSLTSKWVGEAEKLVKTLFQVAISRQPSVIFMDEIDSIMSTRSTSENEA 198
Cdd:pfam00004   1 LLLYGPPGTGKTTLAKAVAKELGAPFIEISGSELVSKYVGESEKRLRELFEAAKKLAPCVIFIDEIDALAGSRGSGGDSE 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 257743172  199 SRRLKSEFLIQFDGVTSNPDDlVIIIGATNKPQELDDAVLRRLVKRIYVPL 249
Cdd:pfam00004  81 SRRVVNQLLTELDGFTSSNSK-VIVIAATNRPDKLDPALLGRFDRIIEFPL 130
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 115-251 2.85e-14

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 69.32  E-value: 2.85e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257743172   115 PARGLLLFGPPGNGKTMLAKAVASESQATFFNV-----------------SASSLTSKWVGEAEKLVKTLFQVAISRQPS 177
Cdd:smart00382   1 PGEVILIVGPPGSGKTTLARALARELGPPGGGViyidgedileevldqllLIIVGGKKASGSGELRLRLALALARKLKPD 80

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 257743172   178 VIFMDEIDSIMSTRSTSENEASRRLKSEFLIQfdgvtsnPDDLVIIIGATNKPQELDDAVLRRLV-KRIYVPLPD 251
Cdd:smart00382  81 VLILDEITSLLDAEQEALLLLLEELRLLLLLK-------SEKNLTVILTTNDEKDLGPALLRRRFdRRIVLLLIL 148
AAA_lid_3 pfam17862
AAA+ lid domain; This entry represents the alpha helical AAA+ lid domain that is found to the ...
 274-309 3.90e-11

AAA+ lid domain; This entry represents the alpha helical AAA+ lid domain that is found to the C-terminus of AAA domains.


Pssm-ID: 465537 [Multi-domain]  Cd Length: 45  Bit Score: 57.55  E-value: 3.90e-11
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 257743172  274 DIDKIVKETEGYSGSDLQALCEEAAMMPIRELGANI 309
Cdd:pfam17862   3 DLEELAERTEGFSGADLEALCREAALAALRRGLEAV 38
Vps4_C pfam09336
Vps4 C terminal oligomerization domain; This domain is found at the C terminal of ATPase ...
 312-352 9.35e-04

Vps4 C terminal oligomerization domain; This domain is found at the C terminal of ATPase proteins involved in vacuolar sorting. It forms an alpha helix structure and is required for oligomerization.


Pssm-ID: 462762 [Multi-domain]  Cd Length: 61  Bit Score: 37.09  E-value: 9.35e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 257743172  312 IQANKV--RSLRYDDFRKSMAVIRPSLSKSKWEELERWNSEFG 352
Cdd:pfam09336  19 IPSDKLlePPVTMKDFLKALKSSRPTVSKEDLEKYEEFTKEFG 61
IS21_help_AAA NF038214
IS21-like element helper ATPase IstB; This protein family model resembles PF01695, but was ...
 102-137 8.42e-03

IS21-like element helper ATPase IstB; This protein family model resembles PF01695, but was built to hit full-length AAA+ ATPases of IS21 family IS (insertion sequence) elements.


Pssm-ID: 439516  Cd Length: 232  Bit Score: 37.45  E-value: 8.42e-03
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 257743172 102 PAKRRDLFTG--LRRpARGLLLFGPPGNGKTMLAKAVA 137
Cdd:NF038214  75 KAQIRELATLdfIER-AENVLLLGPPGTGKTHLAIALG 111
 
Name Accession Description Interval E-value
RecA-like_spastin cd19524
ATPase domain of spastin; Spastin is an ATP-dependent microtubule-severing protein involved in ...
 84-247 1.03e-104

ATPase domain of spastin; Spastin is an ATP-dependent microtubule-severing protein involved in microtubule dynamics; it specifically recognizes and cuts microtubules that are polyglutamylated. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410932 [Multi-domain]  Cd Length: 164  Bit Score: 304.47  E-value: 1.03e-104
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257743172  84 DVAGLNGAKQALLEMVILPAKRRDLFTGLRRPARGLLLFGPPGNGKTMLAKAVASESQATFFNVSASSLTSKWVGEAEKL 163
Cdd:cd19524    1 DIAGQDLAKQALQEMVILPSLRPELFTGLRAPARGLLLFGPPGNGKTMLAKAVAAESNATFFNISAASLTSKYVGEGEKL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257743172 164 VKTLFQVAISRQPSVIFMDEIDSIMSTRSTSENEASRRLKSEFLIQFDGVTSNPDDLVIIIGATNKPQELDDAVLRRLVK 243
Cdd:cd19524   81 VRALFAVARELQPSIIFIDEVDSLLSERSEGEHEASRRLKTEFLIEFDGVQSNGDDRVLVMGATNRPQELDDAVLRRFTK 160


                 ....
gi 257743172 244 RIYV 247
Cdd:cd19524  161 RVYV 164
RecA-like_Figl-1 cd19525
ATPase domain of Fidgetin-Like 1 (FIGL-1); FIGL-1 may participate in DNA repair in the nucleus; ...
 62-247 7.05e-91

ATPase domain of Fidgetin-Like 1 (FIGL-1); FIGL-1 may participate in DNA repair in the nucleus; it may be involved in DNA double-strand break repair via homologous recombination. Caenorhabditis elegans FIGL-1 is a nuclear protein and controls the mitotic progression in the germ line and mouse FIGL-1 may be involved in the control of male meiosis. human FIGL-1 has been shown to be a centrosome protein involved in ciliogenesis perhaps as a microtubule-severing protein. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410933 [Multi-domain]  Cd Length: 186  Bit Score: 270.32  E-value: 7.05e-91
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257743172  62 DDKLVEMINTTIVDRSPSVKWDDVAGLNGAKQALLEMVILPAKRRDLFTGLRRPARGLLLFGPPGNGKTMLAKAVASESQ 141
Cdd:cd19525    1 EPKMIELIMSEIMDHGPPINWADIAGLEFAKKTIKEIVVWPMLRPDIFTGLRGPPKGILLFGPPGTGKTLIGKCIASQSG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257743172 142 ATFFNVSASSLTSKWVGEAEKLVKTLFQVAISRQPSVIFMDEIDSIMSTRSTSENEASRRLKSEFLIQFDGVTSNPDDLV 221
Cdd:cd19525   81 ATFFSISASSLTSKWVGEGEKMVRALFSVARCKQPAVIFIDEIDSLLSQRGEGEHESSRRIKTEFLVQLDGATTSSEDRI 160

                        170       180
                 ....*....|....*....|....*.
gi 257743172 222 IIIGATNKPQELDDAVLRRLVKRIYV 247
Cdd:cd19525  161 LVVGATNRPQEIDEAARRRLVKRLYI 186
RecA-like_VPS4-like cd19509
ATPase domain of VPS4, ATAD1, K, KTNA1, Spastin, FIGL-1 and similar ATPase domains; This ...
 85-247 6.23e-90

ATPase domain of VPS4, ATAD1, K, KTNA1, Spastin, FIGL-1 and similar ATPase domains; This subfamily includes the ATPase domains of vacuolar protein sorting-associated protein 4 (VPS4), ATPase family AAA domain-containing protein 1 (ATAD1, also known as Thorase), Katanin p60 ATPase-containing subunit A1 (KTNA1), Spastin, and Fidgetin-Like 1 (FIGL-1). This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410917 [Multi-domain]  Cd Length: 163  Bit Score: 266.91  E-value: 6.23e-90
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257743172  85 VAGLNGAKQALLEMVILPAKRRDLFTGLRRPARGLLLFGPPGNGKTMLAKAVASESQATFFNVSASSLTSKWVGEAEKLV 164
Cdd:cd19509    1 IAGLDDAKEALKEAVILPSLRPDLFPGLRGPPRGILLYGPPGTGKTLLARAVASESGSTFFSISASSLVSKWVGESEKIV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257743172 165 KTLFQVAISRQPSVIFMDEIDSIMSTRSTSENEASRRLKSEFLIQFDGVTSNPDDLVIIIGATNKPQELDDAVLRRLVKR 244
Cdd:cd19509   81 RALFALARELQPSIIFIDEIDSLLSERGSGEHEASRRVKTEFLVQMDGVLNKPEDRVLVLGATNRPWELDEAFLRRFEKR 160


                 ...
gi 257743172 245 IYV 247
Cdd:cd19509  161 IYI 163
RPT1 COG1222
ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein ...
 34-340 3.84e-88

ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440835 [Multi-domain]  Cd Length: 326  Bit Score: 268.03  E-value: 3.84e-88
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257743172  34 ARGGVATPRNPKDAAASPKPVKES------GNVYDDKLVEMINTTIVDRSPSVKWDDVAGLNGAKQALLEMVILPAKRRD 107
Cdd:COG1222   23 ERLGVELALLLQPVKALELLEEAPalllndANLTQKRLGTPRGTAVPAESPDVTFDDIGGLDEQIEEIREAVELPLKNPE 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257743172 108 LFT--GLRRPaRGLLLFGPPGNGKTMLAKAVASESQATFFNVSASSLTSKWVGEAEKLVKTLFQVAISRQPSVIFMDEID 185
Cdd:COG1222  103 LFRkyGIEPP-KGVLLYGPPGTGKTLLAKAVAGELGAPFIRVRGSELVSKYIGEGARNVREVFELAREKAPSIIFIDEID 181

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257743172 186 SIMSTRS-TSENEASRRLKSEFLIQFDGVTSNPDdlVIIIGATNKPQELDDAVLR--RLVKRIYVPLPDSNVRKLLFKTK 262
Cdd:COG1222  182 AIAARRTdDGTSGEVQRTVNQLLAELDGFESRGD--VLIIAATNRPDLLDPALLRpgRFDRVIEVPLPDEEAREEILKIH 259

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 257743172 263 LKCQPhsLSDG-DIDKIVKETEGYSGSDLQALCEEAAMMPIRElganiltiqanKVRSLRYDDFRKSMAVIRPSLSKSK 340
Cdd:COG1222  260 LRDMP--LADDvDLDKLAKLTEGFSGADLKAIVTEAGMFAIRE-----------GRDTVTMEDLEKAIEKVKKKTETAT 325
cell_div_CdvC NF041006
cell division protein CdvC;
53-351 1.32e-78

cell division protein CdvC;


Pssm-ID: 468935 [Multi-domain]  Cd Length: 371  Bit Score: 245.41  E-value: 1.32e-78
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257743172  53 PVKESGNVYDDKLVEMInttIVDRSPSVKWDDVAGLNGAKQALLEMVILPAKRRDLFTgLRRPaRGLLLFGPPGNGKTML 132
Cdd:NF041006  76 PAEPAGPDVEKESDEEL---VVKEKPKVTFSDIVGLEDVKEALKEAIVYPSKRPDLFP-LGWP-RGILLYGPPGCGKTML 150

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257743172 133 AKAVASESQATFFNVSASSLTSKWVGEAEKLVKTLFQVA--ISRQ---PSVIFMDEIDSIMSTRStSENEASRRLKSEFL 207
Cdd:NF041006 151 AAAVANEIDSEFIHVDAASIMSKWLGEAEKNVAKIFKKAreKSKEegkPAIIFIDEIDALLGVYS-SEVGGEVRVRNQFL 229

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257743172 208 IQFDGVTSNPDDL-VIIIGATNKPQELDDAVLRRLVKRIYVPLPDSNVRKLLFK---TKLKCQPhslsDGDIDKIVKETE 283
Cdd:NF041006 230 KEMDGLQDKSENYhVYVIGATNKPWRLDEPFLRRFQKRIYIPLPDREQRLELLKyytSKIKLEN----DVDLDELAEMTE 305

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 257743172 284 GYSGSDLQALCEEAAMMPIRELGANiltiQANKVRSLRYDDFRKSMAVIRPSLSKSKWEELERWNSEF 351
Cdd:NF041006 306 GYTASDIRDIVQAAHMRVVKEMFEK----GLGEPRPITMEDFKEVLKIRKPSVNQEMLKAYEAWHEKF 369
RecA-like_VPS4 cd19521
ATPase domain of vacuolar protein sorting-associated protein 4; Vacuolar protein ...
 78-247 8.41e-75

ATPase domain of vacuolar protein sorting-associated protein 4; Vacuolar protein sorting-associated protein 4 (Vps4) is believed to be involved in intracellular protein transport out of a prevacuolar endosomal compartment. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410929 [Multi-domain]  Cd Length: 170  Bit Score: 228.59  E-value: 8.41e-75
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257743172  78 PSVKWDDVAGLNGAKQALLEMVILPAKRRDLFTGLRRPARGLLLFGPPGNGKTMLAKAVASESQATFFNVSASSLTSKWV 157
Cdd:cd19521    2 PNVKWEDVAGLEGAKEALKEAVILPVKFPHLFTGNRKPWSGILLYGPPGTGKSYLAKAVATEANSTFFSVSSSDLVSKWM 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257743172 158 GEAEKLVKTLFQVAISRQPSVIFMDEIDSIMSTRSTSENEASRRLKSEFLIQFDGVtSNPDDLVIIIGATNKPQELDDAV 237
Cdd:cd19521   82 GESEKLVKQLFAMARENKPSIIFIDEVDSLCGTRGEGESEASRRIKTELLVQMNGV-GNDSQGVLVLGATNIPWQLDSAI 160

                        170
                 ....*....|
gi 257743172 238 LRRLVKRIYV 247
Cdd:cd19521  161 RRRFEKRIYI 170
SpoVK COG0464
AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle ...
 74-309 1.87e-69

AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 440232 [Multi-domain]  Cd Length: 397  Bit Score: 222.48  E-value: 1.87e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257743172  74 VDRSPSVKWDDVAGLNGAKQALLEMVILPAKRRDLFT--GLRRPaRGLLLFGPPGNGKTMLAKAVASESQATFFNVSASS 151
Cdd:COG0464  148 LLELREAILDDLGGLEEVKEELRELVALPLKRPELREeyGLPPP-RGLLLYGPPGTGKTLLARALAGELGLPLIEVDLSD 226

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257743172 152 LTSKWVGEAEKLVKTLFQVAISRQPSVIFMDEIDSIMSTRSTSENEASRRLKSEFLIQFDGVTSNpddlVIIIGATNKPQ 231
Cdd:COG0464  227 LVSKYVGETEKNLREVFDKARGLAPCVLFIDEADALAGKRGEVGDGVGRRVVNTLLTEMEELRSD----VVVIAATNRPD 302

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 257743172 232 ELDDAVLRRLVKRIYVPLPDSNVRKLLFKTKLKCQPHSlSDGDIDKIVKETEGYSGSDLQALCEEAAMMPIRELGANI 309
Cdd:COG0464  303 LLDPALLRRFDEIIFFPLPDAEERLEIFRIHLRKRPLD-EDVDLEELAEATEGLSGADIRNVVRRAALQALRLGREPV 379
RecA-like_ATAD1 cd19520
ATPase domain of ATPase family AAA domain-containing protein 1 and similar ATPase domains; ...
 84-247 3.21e-67

ATPase domain of ATPase family AAA domain-containing protein 1 and similar ATPase domains; ATPase family AAA domain-containing protein 1 (ATAD1, also known as Thorase) is an ATPase that plays a critical role in regulating the surface expression of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, thereby regulating synaptic plasticity, learning and memory. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410928 [Multi-domain]  Cd Length: 166  Bit Score: 209.20  E-value: 3.21e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257743172  84 DVAGLNGAKQALLEMVILPAKRRDLF--TGLRRPARGLLLFGPPGNGKTMLAKAVASESQATFFNVSASSLTSKWVGEAE 161
Cdd:cd19520    1 DIGGLDEVITELKELVILPLQRPELFdnSRLLQPPKGVLLYGPPGCGKTMLAKATAKEAGARFINLQVSSLTDKWYGESQ 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257743172 162 KLVKTLFQVAISRQPSVIFMDEIDSIMSTRSTSENEASRRLKSEFLIQFDGVTSNPDDLVIIIGATNKPQELDDAVLRRL 241
Cdd:cd19520   81 KLVAAVFSLASKLQPSIIFIDEIDSFLRQRSSTDHEATAMMKAEFMSLWDGLSTDGNCRVIVMGATNRPQDLDEAILRRM 160


                 ....*.
gi 257743172 242 VKRIYV 247
Cdd:cd19520  161 PKRFHI 166
RecA-like_KTNA1 cd19522
Katanin p60 ATPase-containing subunit A1; Katanin p60 ATPase-containing subunit A1 (KTNA1) is ...
 84-247 1.24e-66

Katanin p60 ATPase-containing subunit A1; Katanin p60 ATPase-containing subunit A1 (KTNA1) is the catalytic subunit of the Katanin complex which is severs microtubules in an ATP-dependent manner, and is implicated in multiple aspects of microtubule dynamics. In addition to the p60 catalytic ATPase subunit, Katanin contains an accessory subunit (p80 or p80-like). The microtubule-severing activity of the ATPase is essential for female meiotic spindle assembly, and male gamete production; and the katanin complex severing microtubules is under tight regulation during the transition from the meiotic to mitotic stage to allow proper embryogenesis. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410930 [Multi-domain]  Cd Length: 170  Bit Score: 207.53  E-value: 1.24e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257743172  84 DVAGLNGAKQALLEMVILPAKRRDLFTGLRRPARGLLLFGPPGNGKTMLAKAVASESQATFFNVSASSLTSKWVGEAEKL 163
Cdd:cd19522    1 DIADLEEAKKLLEEAVVLPMWMPEFFKGIRRPWKGVLMVGPPGTGKTLLAKAVATECGTTFFNVSSSTLTSKYRGESEKL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257743172 164 VKTLFQVAISRQPSVIFMDEIDSIMSTRSTS-ENEASRRLKSEFLIQFDGVT-----SNPDDLVIIIGATNKPQELDDAV 237
Cdd:cd19522   81 VRLLFEMARFYAPTTIFIDEIDSICSRRGTSeEHEASRRVKSELLVQMDGVGgasenDDPSKMVMVLAATNFPWDIDEAL 160

                        170
                 ....*....|
gi 257743172 238 LRRLVKRIYV 247
Cdd:cd19522  161 RRRLEKRIYI 170
CDC48 TIGR01243
AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two ...
 78-352 1.79e-65

AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two members each from three archaeal species. It also includes yeast CDC48 (cell division control protein 48) and the human ortholog, transitional endoplasmic reticulum ATPase (valosin-containing protein). These proteins in eukaryotes are involved in the budding and transfer of membrane from the transitional endoplasmic reticulum to the Golgi apparatus.


Pssm-ID: 273521 [Multi-domain]  Cd Length: 733  Bit Score: 220.16  E-value: 1.79e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257743172   78 PSVKWDDVAGLNGAKQALLEMVILPAKRRDLFTGLR-RPARGLLLFGPPGNGKTMLAKAVASESQATFFNVSASSLTSKW 156
Cdd:TIGR01243 448 PNVRWSDIGGLEEVKQELREAVEWPLKHPEIFEKMGiRPPKGVLLFGPPGTGKTLLAKAVATESGANFIAVRGPEILSKW 527

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257743172  157 VGEAEKLVKTLFQVAISRQPSVIFMDEIDSIMSTRSTSENEA-SRRLKSEFLIQFDGVTSNPDdlVIIIGATNKPQELDD 235
Cdd:TIGR01243 528 VGESEKAIREIFRKARQAAPAIIFFDEIDAIAPARGARFDTSvTDRIVNQLLTEMDGIQELSN--VVVIAATNRPDILDP 605

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257743172  236 AVLR--RLVKRIYVPLPDSNVRKLLFKTKLKCQPHSlSDGDIDKIVKETEGYSGSDLQALCEEAAMMPIRELGANIL--- 310
Cdd:TIGR01243 606 ALLRpgRFDRLILVPPPDEEARKEIFKIHTRSMPLA-EDVDLEELAEMTEGYTGADIEAVCREAAMAALRESIGSPAkek 684

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 257743172  311 ----TIQANKVRSLRYDDFRKSMAVIRPSLSKSKWEELERWNSEFG 352
Cdd:TIGR01243 685 levgEEEFLKDLKVEMRHFLEALKKVKPSVSKEDMLRYERLAKELK 730
PRK03992 PRK03992
proteasome-activating nucleotidase; Provisional
 74-304 1.27e-62

proteasome-activating nucleotidase; Provisional


Pssm-ID: 179699 [Multi-domain]  Cd Length: 389  Bit Score: 204.68  E-value: 1.27e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257743172  74 VDRSPSVKWDDVAGLNGAKQALLEMVILPAKRRDLFT--GLRrPARGLLLFGPPGNGKTMLAKAVASESQATFFNVSASS 151
Cdd:PRK03992 122 VIESPNVTYEDIGGLEEQIREVREAVELPLKKPELFEevGIE-PPKGVLLYGPPGTGKTLLAKAVAHETNATFIRVVGSE 200

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257743172 152 LTSKWVGEAEKLVKTLFQVAISRQPSVIFMDEIDSIMSTRSTSENEASR---RLKSEFLIQFDGVtsNPDDLVIIIGATN 228
Cdd:PRK03992 201 LVQKFIGEGARLVRELFELAREKAPSIIFIDEIDAIAAKRTDSGTSGDRevqRTLMQLLAEMDGF--DPRGNVKIIAATN 278

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 257743172 229 KPQELDDAVLR--RLVKRIYVPLPDSNVRKLLFKTKLKCQphSLSDG-DIDKIVKETEGYSGSDLQALCEEAAMMPIRE 304
Cdd:PRK03992 279 RIDILDPAILRpgRFDRIIEVPLPDEEGRLEILKIHTRKM--NLADDvDLEELAELTEGASGADLKAICTEAGMFAIRD 355
AAA pfam00004
ATPase family associated with various cellular activities (AAA); AAA family proteins often ...
 119-249 5.10e-53

ATPase family associated with various cellular activities (AAA); AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.


Pssm-ID: 459627 [Multi-domain]  Cd Length: 130  Bit Score: 171.24  E-value: 5.10e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257743172  119 LLLFGPPGNGKTMLAKAVASESQATFFNVSASSLTSKWVGEAEKLVKTLFQVAISRQPSVIFMDEIDSIMSTRSTSENEA 198
Cdd:pfam00004   1 LLLYGPPGTGKTTLAKAVAKELGAPFIEISGSELVSKYVGESEKRLRELFEAAKKLAPCVIFIDEIDALAGSRGSGGDSE 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 257743172  199 SRRLKSEFLIQFDGVTSNPDDlVIIIGATNKPQELDDAVLRRLVKRIYVPL 249
Cdd:pfam00004  81 SRRVVNQLLTELDGFTSSNSK-VIVIAATNRPDKLDPALLGRFDRIIEFPL 130
CDC48 TIGR01243
AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two ...
 78-344 3.79e-52

AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two members each from three archaeal species. It also includes yeast CDC48 (cell division control protein 48) and the human ortholog, transitional endoplasmic reticulum ATPase (valosin-containing protein). These proteins in eukaryotes are involved in the budding and transfer of membrane from the transitional endoplasmic reticulum to the Golgi apparatus.


Pssm-ID: 273521 [Multi-domain]  Cd Length: 733  Bit Score: 183.95  E-value: 3.79e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257743172   78 PSVKWDDVAGLNGAKQALLEMVILPAKRRDLFTGLR-RPARGLLLFGPPGNGKTMLAKAVASESQATFFNVSASSLTSKW 156
Cdd:TIGR01243 173 PKVTYEDIGGLKEAKEKIREMVELPMKHPELFEHLGiEPPKGVLLYGPPGTGKTLLAKAVANEAGAYFISINGPEIMSKY 252

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257743172  157 VGEAEKLVKTLFQVAISRQPSVIFMDEIDSIMSTRSTSENEASRRLKSEFLIQFDGVTSNPDdlVIIIGATNKPQELDDA 236
Cdd:TIGR01243 253 YGESEERLREIFKEAEENAPSIIFIDEIDAIAPKREEVTGEVEKRVVAQLLTLMDGLKGRGR--VIVIGATNRPDALDPA 330

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257743172  237 VLR--RLVKRIYVPLPDSNVRKLLFKTKLKCQPHSlSDGDIDKIVKETEGYSGSDLQALCEEAAMMPIREL------GAN 308
Cdd:TIGR01243 331 LRRpgRFDREIVIRVPDKRARKEILKVHTRNMPLA-EDVDLDKLAEVTHGFVGADLAALAKEAAMAALRRFiregkiNFE 409

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 257743172  309 ILTIQANKVRSLRY--DDFRKSMAVIRPSLSKS--------KWEEL 344
Cdd:TIGR01243 410 AEEIPAEVLKELKVtmKDFMEALKMVEPSAIREvlvevpnvRWSDI 455
RecA-like_fidgetin cd19523
ATPase domain of fidgetin; Fidgetin (FIGN) is a ATP-dependent microtubule severing protein. ...
 84-247 6.63e-52

ATPase domain of fidgetin; Fidgetin (FIGN) is a ATP-dependent microtubule severing protein. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410931 [Multi-domain]  Cd Length: 163  Bit Score: 169.68  E-value: 6.63e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257743172  84 DVAGLNGAKQALLEMVILPAKRRDLFTGLRRPARGLLLFGPPGNGKTMLAKAVASESQATFFNVSASSLTSKWVGEAEKL 163
Cdd:cd19523    1 DIAGLGALKAAIKEEVLWPLLRPDAFSGLLRLPRSILLFGPRGTGKTLLGRCLASQLGATFLRLRGSTLVAKWAGEGEKI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257743172 164 VKTLFQVAISRQPSVIFMDEIDSIMSTRsTSENEASRRLKSEFLIQFDGVTSNPDDLVIIIGATNKPQELDDAVLRRLVK 243
Cdd:cd19523   81 LQASFLAARCRQPSVLFISDLDALLSSQ-DDEASPVGRLQVELLAQLDGVLGSGEDGVLVVCTTSKPEEIDESLRRYFSK 159


                 ....
gi 257743172 244 RIYV 247
Cdd:cd19523  160 RLLV 163
PTZ00454 PTZ00454
26S protease regulatory subunit 6B-like protein; Provisional
 63-303 1.15e-48

26S protease regulatory subunit 6B-like protein; Provisional


Pssm-ID: 240423 [Multi-domain]  Cd Length: 398  Bit Score: 168.40  E-value: 1.15e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257743172  63 DKLVEMINttiVDRSPSVKWDDVAGLNGAKQALLEMVILPAKRRDLFTGLR-RPARGLLLFGPPGNGKTMLAKAVASESQ 141
Cdd:PTZ00454 128 DSSIQLLQ---MSEKPDVTYSDIGGLDIQKQEIREAVELPLTCPELYEQIGiDPPRGVLLYGPPGTGKTMLAKAVAHHTT 204

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257743172 142 ATFFNVSASSLTSKWVGEAEKLVKTLFQVAISRQPSVIFMDEIDSIMSTRSTSENEASR---RLKSEFLIQFDGVTSNPD 218
Cdd:PTZ00454 205 ATFIRVVGSEFVQKYLGEGPRMVRDVFRLARENAPSIIFIDEVDSIATKRFDAQTGADRevqRILLELLNQMDGFDQTTN 284

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257743172 219 dlVIIIGATNKPQELDDAVLR--RLVKRIYVPLPDSNVRKLLFKT---KLKCQPhslsDGDIDKIVKETEGYSGSDLQAL 293
Cdd:PTZ00454 285 --VKVIMATNRADTLDPALLRpgRLDRKIEFPLPDRRQKRLIFQTitsKMNLSE----EVDLEDFVSRPEKISAADIAAI 358

                        250
                 ....*....|
gi 257743172 294 CEEAAMMPIR 303
Cdd:PTZ00454 359 CQEAGMQAVR 368
RecA-like_CDC48_r2-like cd19511
second of two ATPase domains of CDC48/p97, PEX1 and -6, VAT and NVL, and similar ATPase ...
 91-247 1.71e-48

second of two ATPase domains of CDC48/p97, PEX1 and -6, VAT and NVL, and similar ATPase domains; This subfamily includes the second of two ATPase domains of the molecular chaperone CDC48 in yeast and p97 or VCP in metazoans, Peroxisomal biogenesis factor 1 (PEX1) and -6 (PEX6), Valosin-containing protein-like ATPase (VAT), and nuclear VCP-like protein (NVL). This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410919 [Multi-domain]  Cd Length: 159  Bit Score: 160.53  E-value: 1.71e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257743172  91 AKQALLEMVILPAKRRDLFTGLR-RPARGLLLFGPPGNGKTMLAKAVASESQATFFNVSASSLTSKWVGEAEKLVKTLFQ 169
Cdd:cd19511    1 VKRELKEAVEWPLKHPDAFKRLGiRPPKGVLLYGPPGCGKTLLAKALASEAGLNFISVKGPELFSKYVGESERAVREIFQ 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257743172 170 VAISRQPSVIFMDEIDSIMSTRSTS-ENEASRRLKSEFLIQFDGVtsNPDDLVIIIGATNKPQELDDAVLR--RLVKRIY 246
Cdd:cd19511   81 KARQAAPCIIFFDEIDSLAPRRGQSdSSGVTDRVVSQLLTELDGI--ESLKGVVVIAATNRPDMIDPALLRpgRLDKLIY 158


                 .
gi 257743172 247 V 247
Cdd:cd19511  159 V 159
RecA-like_CDC48_NLV2_r1-like cd19503
first of two ATPase domains of CDC48 and NLV2, and similar ATPase domains; CDC48 in yeast and ...
 84-240 4.64e-48

first of two ATPase domains of CDC48 and NLV2, and similar ATPase domains; CDC48 in yeast and p97 or VCP metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the first of the two ATPase domains. This subfamily also includes the first of the two ATPase domains of NVL (nuclear VCP-like protein) 2, an isoform of NVL mainly present in the nucleolus, which is involved in ribosome biogenesis, in telomerase assembly and the regulation of telomerase activity, and in pre-rRNA processing. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410911 [Multi-domain]  Cd Length: 165  Bit Score: 159.76  E-value: 4.64e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257743172  84 DVAGLNGAKQALLEMVILPAKRRDLFTGLR-RPARGLLLFGPPGNGKTMLAKAVASESQATFFNVSASSLTSKWVGEAEK 162
Cdd:cd19503    1 DIGGLDEQIASLKELIELPLKYPELFRALGlKPPRGVLLHGPPGTGKTLLARAVANEAGANFLSISGPSIVSKYLGESEK 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 257743172 163 LVKTLFQVAISRQPSVIFMDEIDSIMSTRSTSENEASRRLKSEFLIQFDGVTSNPDdlVIIIGATNKPQELDDAvLRR 240
Cdd:cd19503   81 NLREIFEEARSHAPSIIFIDEIDALAPKREEDQREVERRVVAQLLTLMDGMSSRGK--VVVIAATNRPDAIDPA-LRR 155
PTZ00361 PTZ00361
26 proteosome regulatory subunit 4-like protein; Provisional
 60-304 1.52e-47

26 proteosome regulatory subunit 4-like protein; Provisional


Pssm-ID: 185575 [Multi-domain]  Cd Length: 438  Bit Score: 166.48  E-value: 1.52e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257743172  60 VYDDKLVEMINTTIVDRSPSVKWDDVAGLNGAKQALLEMVILPAKRRDLFTGLR-RPARGLLLFGPPGNGKTMLAKAVAS 138
Cdd:PTZ00361 160 ILLDEVDPLVSVMKVDKAPLESYADIGGLEQQIQEIKEAVELPLTHPELYDDIGiKPPKGVILYGPPGTGKTLLAKAVAN 239

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257743172 139 ESQATFFNVSASSLTSKWVGEAEKLVKTLFQVAISRQPSVIFMDEIDSIMSTR----STSENEASRRLkSEFLIQFDGVT 214
Cdd:PTZ00361 240 ETSATFLRVVGSELIQKYLGDGPKLVRELFRVAEENAPSIVFIDEIDAIGTKRydatSGGEKEIQRTM-LELLNQLDGFD 318

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257743172 215 SNPDdlVIIIGATNKPQELDDAVLR--RLVKRIYVPLPDSNVRKLLFktKLKCQPHSLS-DGDIDKIVKETEGYSGSDLQ 291
Cdd:PTZ00361 319 SRGD--VKVIMATNRIESLDPALIRpgRIDRKIEFPNPDEKTKRRIF--EIHTSKMTLAeDVDLEEFIMAKDELSGADIK 394

                        250
                 ....*....|...
gi 257743172 292 ALCEEAAMMPIRE 304
Cdd:PTZ00361 395 AICTEAGLLALRE 407
RecA-like_protease cd19481
proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of ...
 91-247 3.57e-47

proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410889 [Multi-domain]  Cd Length: 158  Bit Score: 157.06  E-value: 3.57e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257743172  91 AKQALLEMVILPAKRRDLFTGLRRPARGLLLFGPPGNGKTMLAKAVASESQATFFNVSASSLTSKWVGEAEKLVKTLFQV 170
Cdd:cd19481    1 LKASLREAVEAPRRGSRLRRYGLGLPKGILLYGPPGTGKTLLAKALAGELGLPLIVVKLSSLLSKYVGESEKNLRKIFER 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257743172 171 AISRQPSVIFMDEIDSIMSTRSTS-ENEASRRLKSEFLIQFDGVTSNPDdlVIIIGATNKPQELDDAVLR--RLVKRIYV 247
Cdd:cd19481   81 ARRLAPCILFIDEIDAIGRKRDSSgESGELRRVLNQLLTELDGVNSRSK--VLVIAATNRPDLLDPALLRpgRFDEVIEF 158
COG1223 COG1223
Predicted ATPase, AAA+ superfamily [General function prediction only];
82-304 6.90e-46

Predicted ATPase, AAA+ superfamily [General function prediction only];


Pssm-ID: 440836 [Multi-domain]  Cd Length: 246  Bit Score: 156.58  E-value: 6.90e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257743172  82 WDDVAGLNGAKQALlEMVILPAKRRDLftgLRR----PARGLLLFGPPGNGKTMLAKAVASESQATFFNVSASSLTSKWV 157
Cdd:COG1223    1 LDDVVGQEEAKKKL-KLIIKELRRREN---LRKfglwPPRKILFYGPPGTGKTMLAEALAGELKLPLLTVRLDSLIGSYL 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257743172 158 GEAEKLVKTLFQvAISRQPSVIFMDEIDSIMSTRS-TSENEASRRLKSEFLIQFDGVTSNpddlVIIIGATNKPQELDDA 236
Cdd:COG1223   77 GETARNLRKLFD-FARRAPCVIFFDEFDAIAKDRGdQNDVGEVKRVVNALLQELDGLPSG----SVVIAATNHPELLDSA 151

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 257743172 237 VLRRLVKRIYVPLPDSNVRKLLFKTKLKCQPHSLSDgDIDKIVKETEGYSGSDLQALCEEAAMMPIRE 304
Cdd:COG1223  152 LWRRFDEVIEFPLPDKEERKEILELNLKKFPLPFEL-DLKKLAKKLEGLSGADIEKVLKTALKKAILE 218
RecA-like_PAN_like cd19502
proteasome activating nucleotidase PAN and related proteasome subunits; This subfamily ...
 82-247 2.12e-44

proteasome activating nucleotidase PAN and related proteasome subunits; This subfamily contains ATPase subunits of the eukaryotic 26S proteasome, and of the archaeal proteasome which carry out ATP-dependent degradation of substrates of the ubiquitin-proteasome pathway. The eukaryotic 26S proteasome consists of a proteolytic 20S core particle (CP), and a 19S regulatory particle (RP) which provides the ATP-dependence and the specificity for ubiquitinated proteins. In the archaea the RP is a homohexameric complex of proteasome-activating nucleotidase (PAN). This subfamily also includes various eukaryotic 26S subunits including, proteasome 26S subunit, ATPase 2 (PSMC2, also known as S7 and MSS1) which is a member of the 19S RP and has a chaperone like activity; and proteasome 20S subunit alpha 6 (PSMA6, also known as IOTA, p27K, and PROS27) which is a member of the 20S CP. This RecA-like_PAN subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410910 [Multi-domain]  Cd Length: 171  Bit Score: 150.57  E-value: 2.12e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257743172  82 WDDVAGLNGAKQALLEMVILPAKRRDLFTGLR-RPARGLLLFGPPGNGKTMLAKAVASESQATFFNVSASSLTSKWVGEA 160
Cdd:cd19502    2 YEDIGGLDEQIREIREVVELPLKHPELFEELGiEPPKGVLLYGPPGTGKTLLAKAVANHTDATFIRVVGSELVQKYIGEG 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257743172 161 EKLVKTLFQVAISRQPSVIFMDEIDSIMSTR----STSENEASRRLkSEFLIQFDGVtsNPDDLVIIIGATNKPQELDDA 236
Cdd:cd19502   82 ARLVRELFEMAREKAPSIIFIDEIDAIGAKRfdsgTGGDREVQRTM-LELLNQLDGF--DPRGNIKVIMATNRPDILDPA 158

                        170
                 ....*....|...
gi 257743172 237 VLR--RLVKRIYV 247
Cdd:cd19502  159 LLRpgRFDRKIEF 171
RecA-like_VCP_r2 cd19529
second of two ATPase domains of Valosin-containing protein-like ATPase (VAT) and similar ...
 91-247 1.51e-43

second of two ATPase domains of Valosin-containing protein-like ATPase (VAT) and similar ATPase domains; The Valosin-containing protein-like ATPase of Thermoplasma acidophilum (VAT), is an archaeal homolog of the ubiquitous Cdc48/p97. It is a protein unfoldase that functions in concert with the 20S proteasome by unfolding proteasome substrates and passing them on for degradation. VAT forms a homohexamer, each monomer contains two tandem ATPase domains, referred to as D1 and D2, and an N-terminal domain. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410937 [Multi-domain]  Cd Length: 159  Bit Score: 148.03  E-value: 1.51e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257743172  91 AKQALLEMVILPAKRRDLFTGLR-RPARGLLLFGPPGNGKTMLAKAVASESQATFFNVSASSLTSKWVGEAEKLVKTLFQ 169
Cdd:cd19529    1 VKQELKEAVEWPLLKPEVFKRLGiRPPKGILLYGPPGTGKTLLAKAVATESNANFISVKGPELLSKWVGESEKAIREIFR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257743172 170 VAISRQPSVIFMDEIDSIMSTR-STSENEASRRLKSEFLIQFDGVTSNPDdlVIIIGATNKPQELDDAVLR--RLVKRIY 246
Cdd:cd19529   81 KARQVAPCVIFFDEIDSIAPRRgTTGDSGVTERVVNQLLTELDGLEEMNG--VVVIAATNRPDIIDPALLRagRFDRLIY 158


                 .
gi 257743172 247 V 247
Cdd:cd19529  159 I 159
RecA-like_CDC48_r2-like cd19528
second of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or ...
 92-247 7.08e-41

second of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP in metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the second of the two ATPase domains. CDC48's roles include in the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis, and in the formation of the nuclear envelope, and of the transitional endoplasmic reticulum (tER). This RecA-like_cdc48_r2-like subfamily belongs to the RecA-like family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410936 [Multi-domain]  Cd Length: 161  Bit Score: 141.11  E-value: 7.08e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257743172  92 KQALLEMVILPAKRRDLFT--GLRrPARGLLLFGPPGNGKTMLAKAVASESQATFFNVSASSLTSKWVGEAEKLVKTLFQ 169
Cdd:cd19528    2 KRELQELVQYPVEHPDKFLkfGMT-PSKGVLFYGPPGCGKTLLAKAIANECQANFISVKGPELLTMWFGESEANVRDIFD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257743172 170 VAISRQPSVIFMDEIDSIMSTRSTS---ENEASRRLKSEFLIQFDGVTSNPDdlVIIIGATNKPQELDDAVLR--RLVKR 244
Cdd:cd19528   81 KARAAAPCVLFFDELDSIAKARGGNigdAGGAADRVINQILTEMDGMNTKKN--VFIIGATNRPDIIDPAILRpgRLDQL 158


                 ...
gi 257743172 245 IYV 247
Cdd:cd19528  159 IYI 161
RecA-like_NVL_r2-like cd19530
second of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL ...
 96-247 8.44e-41

second of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL exists in two forms with N-terminal extensions of different lengths in mammalian cells. NVL has two alternatively spliced isoforms, a short form, NVL1, and a long form, NVL2. NVL2, the major species, is mainly present in the nucleolus, whereas NVL1 is nucleoplasmic. Each has an N-terminal domain, followed by two tandem ATPase domains; this subfamily includes the first of the two ATPase domains. NVL2 is involved in the biogenesis of the 60S ribosome subunit by associating specifically with ribosome protein L5 and modulating the function of DOB1. NVL2 is also required for telomerase assembly and the regulation of telomerase activity, and is involved in pre-rRNA processing. The role of NVL1 is unclear. This RecA-like_NVL_r1-like subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410938 [Multi-domain]  Cd Length: 161  Bit Score: 140.70  E-value: 8.44e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257743172  96 LEMVIL-PAKRRDLFT--GLRRPArGLLLFGPPGNGKTMLAKAVASESQATFFNVSASSLTSKWVGEAEKLVKTLFQVAI 172
Cdd:cd19530    8 LTMSILrPIKRPDIYKalGIDLPT-GVLLYGPPGCGKTLLAKAVANESGANFISVKGPELLNKYVGESERAVRQVFQRAR 86

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 257743172 173 SRQPSVIFMDEIDSIMSTRSTSENEASRRLKSEFLIQFDGVTSNPDdlVIIIGATNKPQELDDAVLR--RLVKRIYV 247
Cdd:cd19530   87 ASAPCVIFFDEVDALVPKRGDGGSWASERVVNQLLTEMDGLEERSN--VFVIAATNRPDIIDPAMLRpgRLDKTLYV 161
RecA-like_NVL_r1-like cd19518
first of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL ...
 84-240 3.47e-40

first of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL exists in two forms with N-terminal extensions of different lengths in mammalian cells. NVL has two alternatively spliced isoforms, a short form, NVL1, and a long form, NVL2. NVL2, the major species, is mainly present in the nucleolus, whereas NVL1 is nucleoplasmic. Each has an N-terminal domain, followed by two tandem ATPase domains; this subfamily includes the first of the two ATPase domains. NVL2 is involved in the biogenesis of the 60S ribosome subunit by associating specifically with ribosome protein L5 and modulating the function of DOB1. NVL2 is also required for telomerase assembly and the regulation of telomerase activity, and is involved in pre-rRNA processing. The role of NVL1 is unclear. This RecA-like_NVL_r1-like subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410926 [Multi-domain]  Cd Length: 169  Bit Score: 139.46  E-value: 3.47e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257743172  84 DVAGLNGAKQALLEMVILPAKRRDLF--TGLRrPARGLLLFGPPGNGKTMLAKAVASESQATFFNVSASSLTSKWVGEAE 161
Cdd:cd19518    1 DIGGMDSTLKELCELLIHPILPPEYFqhLGVE-PPRGVLLHGPPGCGKTMLANAIAGELKVPFLKISATEIVSGVSGESE 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257743172 162 KLVKTLFQVAISRQPSVIFMDEIDSIMSTRSTSENEASRRLKSEFLIQFDGVTSNPDD--LVIIIGATNKPQELDDAvLR 239
Cdd:cd19518   80 EKIRELFDQAISNAPCIVFIDEIDAITPKRESAQREMERRIVSQLLTCMDELNNEKTAggPVLVIGATNRPDSLDPA-LR 158


                 .
gi 257743172 240 R 240
Cdd:cd19518  159 R 159
RecA-like_FtsH cd19501
ATP-dependent zinc metalloprotease FtsH; FtsH ATPase is a processive, ATP-dependent zinc ...
 80-247 7.53e-40

ATP-dependent zinc metalloprotease FtsH; FtsH ATPase is a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. It is anchored to the cytoplasmic membrane such that the amino- and carboxy-termini are exposed to the cytoplasm. It presents a membrane-bound hexameric structure that is able to unfold and degrade protein substrates. It is comprised of an N-terminal transmembrane region and the larger C-terminal cytoplasmic region, which consists of an ATPase domain and a protease domain. This RecA-Like FTsH subfamily represents the ATPase domain, and belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410909 [Multi-domain]  Cd Length: 171  Bit Score: 138.52  E-value: 7.53e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257743172  80 VKWDDVAGLNGAKQALLEMVIL---PAKRRDLftGLRRPaRGLLLFGPPGNGKTMLAKAVASESQATFFNVSASSLTSKW 156
Cdd:cd19501    1 VTFKDVAGCEEAKEELKEVVEFlknPEKFTKL--GAKIP-KGVLLVGPPGTGKTLLAKAVAGEAGVPFFSISGSDFVEMF 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257743172 157 VGEAEKLVKTLFQVAISRQPSVIFMDEIDSIMSTRST----SENEASRRLkSEFLIQFDGVTSNPDdlVIIIGATNKPQE 232
Cdd:cd19501   78 VGVGASRVRDLFEQAKKNAPCIVFIDEIDAVGRKRGAglggGHDEREQTL-NQLLVEMDGFESNTG--VIVIAATNRPDV 154

                        170
                 ....*....|....*..
gi 257743172 233 LDDAVLR--RLVKRIYV 247
Cdd:cd19501  155 LDPALLRpgRFDRQVYV 171
RecA-like_CDC48_r1-like cd19519
first of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP ...
 84-240 3.19e-39

first of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the first of the two ATPase domains. CDC48's roles include in the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis, and in the formation of the nuclear envelope, and of the transitional endoplasmic reticulum (tER). This RecA-like_cdc48_r1-like subfamily belongs to the RecA-like family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410927 [Multi-domain]  Cd Length: 166  Bit Score: 136.80  E-value: 3.19e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257743172  84 DVAGLNGAKQALLEMVILPAKRRDLFTGLR-RPARGLLLFGPPGNGKTMLAKAVASESQATFFNVSASSLTSKWVGEAEK 162
Cdd:cd19519    1 DIGGCRKQLAQIREMVELPLRHPELFKAIGiKPPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESES 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 257743172 163 LVKTLFQVAISRQPSVIFMDEIDSIMSTRSTSENEASRRLKSEFLIQFDGVTSNPDdlVIIIGATNKPQELDDAvLRR 240
Cdd:cd19519   81 NLRKAFEEAEKNAPAIIFIDEIDAIAPKREKTHGEVERRIVSQLLTLMDGLKQRAH--VIVMAATNRPNSIDPA-LRR 155
ftsH CHL00176
cell division protein; Validated
 80-317 1.44e-37

cell division protein; Validated


Pssm-ID: 214386 [Multi-domain]  Cd Length: 638  Bit Score: 142.50  E-value: 1.44e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257743172  80 VKWDDVAGLNGAKQALLEMV-ILPAKRRDLFTGLRRPaRGLLLFGPPGNGKTMLAKAVASESQATFFNVSASSLTSKWVG 158
Cdd:CHL00176 180 ITFRDIAGIEEAKEEFEEVVsFLKKPERFTAVGAKIP-KGVLLVGPPGTGKTLLAKAIAGEAEVPFFSISGSEFVEMFVG 258

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257743172 159 EAEKLVKTLFQVAISRQPSVIFMDEIDSIMSTRST---SENEASRRLKSEFLIQFDGVTSNPDdlVIIIGATNKPQELDD 235
Cdd:CHL00176 259 VGAARVRDLFKKAKENSPCIVFIDEIDAVGRQRGAgigGGNDEREQTLNQLLTEMDGFKGNKG--VIVIAATNRVDILDA 336

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257743172 236 AVLR--RLVKRIYVPLPDSNVRKLLFKTKLKCQPHSlSDGDIDKIVKETEGYSGSDLQALCEEAAMMPIRElgaNILTIQ 313
Cdd:CHL00176 337 ALLRpgRFDRQITVSLPDREGRLDILKVHARNKKLS-PDVSLELIARRTPGFSGADLANLLNEAAILTARR---KKATIT 412


                 ....
gi 257743172 314 ANKV 317
Cdd:CHL00176 413 MKEI 416
RecA-like_PEX6_r2 cd19527
second of two ATPase domains of Peroxisomal biogenesis factor 6 (PEX6); PEX6(also known as ...
 92-247 2.19e-35

second of two ATPase domains of Peroxisomal biogenesis factor 6 (PEX6); PEX6(also known as Peroxin61)/PEX1 is a protein unfoldase; PEX6 and PEX1 form a heterohexameric Type-2 AAA-ATPase complex and are essential for peroxisome biogenesis as they are required for the import of folded proteins into the peroxisomal matrix. This subfamily represents the second ATPase domain of PEX6. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410935 [Multi-domain]  Cd Length: 160  Bit Score: 126.47  E-value: 2.19e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257743172  92 KQALLEMVILPAKRRDLFTGLRRPARGLLLFGPPGNGKTMLAKAVASESQATFFNVSASSLTSKWVGEAEKLVKTLFQVA 171
Cdd:cd19527    2 KKEILDTIQLPLEHPELFSSGLRKRSGILLYGPPGTGKTLLAKAIATECSLNFLSVKGPELINMYIGESEANVREVFQKA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257743172 172 ISRQPSVIFMDEIDSIMSTRSTSENEAS--RRLKSEFLIQFDGVTSNPDDlVIIIGATNKPQELDDAVLR--RLVKRIYV 247
Cdd:cd19527   82 RDAKPCVIFFDELDSLAPSRGNSGDSGGvmDRVVSQLLAELDGMSSSGQD-VFVIGATNRPDLLDPALLRpgRFDKLLYL 160
hflB PRK10733
ATP-dependent zinc metalloprotease FtsH;
84-303 1.63e-34

ATP-dependent zinc metalloprotease FtsH;


Pssm-ID: 182683 [Multi-domain]  Cd Length: 644  Bit Score: 133.62  E-value: 1.63e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257743172  84 DVAGLNGAKQALLEMVIL---PAKRRDLftGLRRPaRGLLLFGPPGNGKTMLAKAVASESQATFFNVSASSLTSKWVGEA 160
Cdd:PRK10733 153 DVAGCDEAKEEVAELVEYlrePSRFQKL--GGKIP-KGVLMVGPPGTGKTLLAKAIAGEAKVPFFTISGSDFVEMFVGVG 229

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257743172 161 EKLVKTLFQVAISRQPSVIFMDEIDSIMSTRST----SENEASRRLkSEFLIQFDGVTSNpdDLVIIIGATNKPQELDDA 236
Cdd:PRK10733 230 ASRVRDMFEQAKKAAPCIIFIDEIDAVGRQRGAglggGHDEREQTL-NQMLVEMDGFEGN--EGIIVIAATNRPDVLDPA 306

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 257743172 237 VLR--RLVKRIYVPLPDSNVRKLLFKTKLKCQPhslSDGDIDK--IVKETEGYSGSDLQALCEEAAMMPIR 303
Cdd:PRK10733 307 LLRpgRFDRQVVVGLPDVRGREQILKVHMRRVP---LAPDIDAaiIARGTPGFSGADLANLVNEAALFAAR 374
RecA-like_Yta7-like cd19517
ATPase domain of Saccharomyces cerevisiae Yta7 and similar ATPase domains; Saccharomyces ...
 84-240 2.75e-33

ATPase domain of Saccharomyces cerevisiae Yta7 and similar ATPase domains; Saccharomyces cerevisiae Yta7 is a chromatin-associated AAA-ATPase involved in regulation of chromatin dynamics. Its human ortholog ANCCA/ATAD2 transcriptionally activates pathways of malignancy in a broad range of cancers. The RecA-like_Yta7 subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410925 [Multi-domain]  Cd Length: 170  Bit Score: 121.46  E-value: 2.75e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257743172  84 DVAGLNGAKQALLEMVILPAKRRDLFTGLR-RPARGLLLFGPPGNGKTMLAKAVASE-----SQATFFNVSASSLTSKWV 157
Cdd:cd19517    1 DIGGLSHYINQLKEMVFFPLLYPEVFAKFKiTPPRGVLFHGPPGTGKTLMARALAAEcskggQKVSFFMRKGADCLSKWV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257743172 158 GEAEKLVKTLFQVAISRQPSVIFMDEIDSIMSTRSTSENEASRRLKSEFLIQFDGVTSNPDdlVIIIGATNKPQELDDAv 237
Cdd:cd19517   81 GEAERQLRLLFEEAYRMQPSIIFFDEIDGLAPVRSSKQEQIHASIVSTLLALMDGLDNRGQ--VVVIGATNRPDALDPA- 157


                 ...
gi 257743172 238 LRR 240
Cdd:cd19517  158 LRR 160
RecA-like_PEX1_r2 cd19526
second of two ATPase domains of Peroxisomal biogenesis factor 1 (PEX1); PEX1(also known as ...
 91-246 6.05e-33

second of two ATPase domains of Peroxisomal biogenesis factor 1 (PEX1); PEX1(also known as Peroxin-1)/PEX6 is a protein unfoldase; PEX1 and PEX6 form a heterohexameric Type-2 AAA-ATPase complex and are essential for peroxisome biogenesis as they are required for the import of folded proteins into the peroxisomal matrix. PEX-1 is required for stability of PEX5. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410934 [Multi-domain]  Cd Length: 158  Bit Score: 120.23  E-value: 6.05e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257743172  91 AKQALLEMVILPAKRRDLFTGLRRPAR-GLLLFGPPGNGKTMLAKAVASESQATFFNVSASSLTSKWVGEAEKLVKTLFQ 169
Cdd:cd19526    1 VKKALEETIEWPSKYPKIFASSPLRLRsGILLYGPPGCGKTLLASAIASECGLNFISVKGPELLNKYIGASEQNVRDLFS 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 257743172 170 VAISRQPSVIFMDEIDSIMSTRSTSENEASRRLKSEFLIQFDGVTSNpdDLVIIIGATNKPQELDDAVLR--RLVKRIY 246
Cdd:cd19526   81 RAQSAKPCILFFDEFDSIAPKRGHDSTGVTDRVVNQLLTQLDGVEGL--DGVYVLAATSRPDLIDPALLRpgRLDKLVY 157
HflB COG0465
ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones];
73-298 3.81e-32

ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440233 [Multi-domain]  Cd Length: 583  Bit Score: 126.69  E-value: 3.81e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257743172  73 IVDRSPSVKWDDVAGLNGAKQALLEMV-IL--PAKRRDLftGLRRPaRGLLLFGPPGNGKTMLAKAVASESQATFFNVSA 149
Cdd:COG0465  132 YDEDKPKVTFDDVAGVDEAKEELQEIVdFLkdPEKFTRL--GAKIP-KGVLLVGPPGTGKTLLAKAVAGEAGVPFFSISG 208

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257743172 150 SSLTSKWVG-EAEKlVKTLFQVAISRQPSVIFMDEIDSIMSTRSTS------ENEasrrlksefliQ--------FDGVT 214
Cdd:COG0465  209 SDFVEMFVGvGASR-VRDLFEQAKKNAPCIIFIDEIDAVGRQRGAGlggghdERE-----------QtlnqllveMDGFE 276

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257743172 215 SNpdDLVIIIGATNKPQELDDAVLR--RLVKRIYVPLPDSNVRKLLFKTKLKCQPHSlSDGDIDKIVKETEGYSGSDLQA 292
Cdd:COG0465  277 GN--EGVIVIAATNRPDVLDPALLRpgRFDRQVVVDLPDVKGREAILKVHARKKPLA-PDVDLEVIARRTPGFSGADLAN 353


                 ....*.
gi 257743172 293 LCEEAA 298
Cdd:COG0465  354 LVNEAA 359
AAA cd00009
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ...
 103-249 2.15e-23

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.


Pssm-ID: 99707 [Multi-domain]  Cd Length: 151  Bit Score: 94.52  E-value: 2.15e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257743172 103 AKRRDLFTGLRRPARGLLLFGPPGNGKTMLAKAVA---SESQATFFNVSASSLTSKWVGEAEK---LVKTLFQVAISRQP 176
Cdd:cd00009    6 AIEALREALELPPPKNLLLYGPPGTGKTTLARAIAnelFRPGAPFLYLNASDLLEGLVVAELFghfLVRLLFELAEKAKP 85

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 257743172 177 SVIFMDEIDSImstrstseneaSRRLKSEFLIQFDGVTSNPD--DLVIIIGATNKP--QELDDAVLRRLVKRIYVPL 249
Cdd:cd00009   86 GVLFIDEIDSL-----------SRGAQNALLRVLETLNDLRIdrENVRVIGATNRPllGDLDRALYDRLDIRIVIPL 151
ycf46 CHL00195
Ycf46; Provisional
 77-349 8.50e-17

Ycf46; Provisional


Pssm-ID: 177094 [Multi-domain]  Cd Length: 489  Bit Score: 81.22  E-value: 8.50e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257743172  77 SPSVKWDDVAGLNGAKQALlemvilpAKRRDLFT------GLRRPaRGLLLFGPPGNGKTMLAKAVASESQATFFNVSAS 150
Cdd:CHL00195 222 SVNEKISDIGGLDNLKDWL-------KKRSTSFSkqasnyGLPTP-RGLLLVGIQGTGKSLTAKAIANDWQLPLLRLDVG 293

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257743172 151 SLTSKWVGEAEKLVKTLFQVAISRQPSVIFMDEIDSIMS-TRSTSENEASRRLKSEFLIQFDGVTSNpddlVIIIGATNK 229
Cdd:CHL00195 294 KLFGGIVGESESRMRQMIRIAEALSPCILWIDEIDKAFSnSESKGDSGTTNRVLATFITWLSEKKSP----VFVVATANN 369

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257743172 230 PQELDDAVLR--RLVKRIYVPLPDSNVRKLLFKTKL-KCQPHSLSDGDIDKIVKETEGYSGSDL-QALCEeaAMMpirel 305
Cdd:CHL00195 370 IDLLPLEILRkgRFDEIFFLDLPSLEEREKIFKIHLqKFRPKSWKKYDIKKLSKLSNKFSGAEIeQSIIE--AMY----- 442

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 257743172 306 ganiltIQANKVRSLRYDDFRKSMAVIRP--SLSKSKWEELERWNS 349
Cdd:CHL00195 443 ------IAFYEKREFTTDDILLALKQFIPlaQTEKEQIEALQNWAS 482
RecA-like_NSF-SEC18_r1-like cd19504
first of two ATPase domains of NSF and SEC18, and similar ATPase domains; ...
 117-239 1.50e-15

first of two ATPase domains of NSF and SEC18, and similar ATPase domains; N-ethylmaleimide-sensitive factor (NSF) and Saccharomyces cerevisiae Vesicular-fusion protein Sec18, key factors for eukaryotic trafficking, are ATPases and SNARE disassembly chaperones. NSF/Sec18 activate or prime SNAREs, the terminal catalysts of membrane fusion. Sec18/NSF associates with SNARE complexes through binding Sec17/alpha-SNAP. Sec18 has an N-terminal cap domain and two nucleotide-binding domains (D1 and D2) which form the two rings of the hexameric complex. The hydrolysis of ATP by D1 generates most of the energy necessary to disassemble inactive SNARE bundles, while the D2 ring binds ATP to stabilize the homohexamer. This subfamily includes the first (D1) ATPase domain of NSF/Sec18, and belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410912 [Multi-domain]  Cd Length: 177  Bit Score: 73.68  E-value: 1.50e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257743172 117 RGLLLFGPPGNGKTMLAKAVasesqATFFN------VSASSLTSKWVGEAEKLVKTLFQVAISRQPS--------VIFMD 182
Cdd:cd19504   36 KGILLYGPPGTGKTLMARQI-----GKMLNarepkiVNGPEILNKYVGESEANIRKLFADAEEEQRRlgansglhIIIFD 110

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 257743172 183 EIDSIMSTRSTSENEAS--RRLKSEFLIQFDGVtsnpDDL--VIIIGATNKPQELDDAVLR 239
Cdd:cd19504  111 EIDAICKQRGSMAGSTGvhDTVVNQLLSKIDGV----EQLnnILVIGMTNRKDLIDEALLR 167
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 115-251 2.85e-14

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 69.32  E-value: 2.85e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257743172   115 PARGLLLFGPPGNGKTMLAKAVASESQATFFNV-----------------SASSLTSKWVGEAEKLVKTLFQVAISRQPS 177
Cdd:smart00382   1 PGEVILIVGPPGSGKTTLARALARELGPPGGGViyidgedileevldqllLIIVGGKKASGSGELRLRLALALARKLKPD 80

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 257743172   178 VIFMDEIDSIMSTRSTSENEASRRLKSEFLIQfdgvtsnPDDLVIIIGATNKPQELDDAVLRRLV-KRIYVPLPD 251
Cdd:smart00382  81 VLILDEITSLLDAEQEALLLLLEELRLLLLLK-------SEKNLTVILTTNDEKDLGPALLRRRFdRRIVLLLIL 148
RecA-like_Pch2-like cd19508
ATPase domain of Pachytene checkpoint 2 (Pch2) and similar ATPase domains; Pch2 (known as ...
 82-247 2.17e-13

ATPase domain of Pachytene checkpoint 2 (Pch2) and similar ATPase domains; Pch2 (known as Thyroid hormone receptor interactor 13 (TRIP13) and 16E1BP) is a key regulator of specific chromosomal events, like the control of G2/prophase processes such as DNA break formation and recombination, checkpoint signaling, and chromosome synapsis. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion


Pssm-ID: 410916 [Multi-domain]  Cd Length: 199  Bit Score: 68.24  E-value: 2.17e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257743172  82 WDDVAGLNGAKQALLEMVILPAK--RRDLFTGLRRPARGLLLFGPPGNGKTMLAKAVASE---------SQATFFNVSAS 150
Cdd:cd19508   16 WESLIYDSNLKSRLLDYVTTTLLfsDKNVNTNLITWNRLVLLHGPPGTGKTSLCKALAQKlsirlssryRYGQLIEINSH 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257743172 151 SLTSKWVGEAEKLVKTLFQVA---ISRQPSVIF--MDEIDSIMSTRS--TSENEASR--RLKSEFLIQFDGVTSNPDDLV 221
Cdd:cd19508   96 SLFSKWFSESGKLVTKMFQKIqelIDDKDALVFvlIDEVESLAAARSasSSGTEPSDaiRVVNAVLTQIDRIKRYHNNVI 175

                        170       180
                 ....*....|....*....|....*.
gi 257743172 222 IIigATNKPQELDDAVLRRLVKRIYV 247
Cdd:cd19508  176 LL--TSNLLEKIDVAFVDRADIKQYI 199
RecA-like_IQCA1 cd19506
ATPase domain of IQ and AAA domain-containing protein 1 (IQCA1); IQCA1 (also known as dynein ...
 117-245 5.53e-13

ATPase domain of IQ and AAA domain-containing protein 1 (IQCA1); IQCA1 (also known as dynein regulatory complex subunit 11, DRC11 and IQCA) is an ATPase subunit of the nexin-dynein regulatory complex (N-DRC). The 9 + 2 axoneme of most motile cilia and flagella consists of nine outer doublet microtubules arranged in a ring surrounding a central pair of two singlet microtubules. The N-DRC complex maintains alignment between outer doublet microtubules and limits microtubule sliding in motile axonemes. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410914 [Multi-domain]  Cd Length: 160  Bit Score: 66.01  E-value: 5.53e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257743172 117 RGLLLFGPPGNGKTMLAKAVASESQATFFNVSASSLTSKWVGEA--EKLVKTLFQVAISRQPSVIFMDEIDSIMSTR--S 192
Cdd:cd19506   27 KSLLLAGPSGVGKKMLVHAICTETGANLFNLSPSNIAGKYPGKNglQMMLHLVLKVARQLQPSVIWIGDAEKTFYKKvpK 106

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 257743172 193 TSENEASRRLKSEFLIQFDGVtsNPDDLVIIIGATNKPQELDDAVLRRLVKRI 245
Cdd:cd19506  107 TEKQLDPKRLKKDLPKILKSL--KPEDRVLIVGTTSRPFEADLKSFCKVYNKI 157
RecA-like_Ycf46-like cd19507
ATPase domain of Ycf46 and similar ATPase domains; Ycf46 may play a role in the regulation of ...
 84-207 7.30e-13

ATPase domain of Ycf46 and similar ATPase domains; Ycf46 may play a role in the regulation of photosynthesis in cyanobacteria, especially in CO2 uptake and utilization. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410915 [Multi-domain]  Cd Length: 161  Bit Score: 65.85  E-value: 7.30e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257743172  84 DVAGLNGAKQALLemvilpaKRRDLFT------GLRRPaRGLLLFGPPGNGKTMLAKAVASESQATFFNVSASSLTSKWV 157
Cdd:cd19507    1 DVGGLDNLKDWLK-------KRKAAFSkqasayGLPTP-KGLLLVGIQGTGKSLTAKAIAGVWQLPLLRLDMGRLFGGLV 72

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 257743172 158 GEAEKLVKTLFQVAISRQPSVIFMDEIDSIMS-TRSTSENEASRRLKSEFL 207
Cdd:cd19507   73 GESESRLRQMIQTAEAIAPCVLWIDEIEKGFSnADSKGDSGTSSRVLGTFL 123
PRK13342 PRK13342
recombination factor protein RarA; Reviewed
 119-323 1.37e-11

recombination factor protein RarA; Reviewed


Pssm-ID: 237355 [Multi-domain]  Cd Length: 413  Bit Score: 65.11  E-value: 1.37e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257743172 119 LLLFGPPGNGKTMLAKAVASESQATFFNVSASslTSKwVGEAEKLVKTLFQVAISRQPSVIFMDEIdsimstrstsenea 198
Cdd:PRK13342  39 MILWGPPGTGKTTLARIIAGATDAPFEALSAV--TSG-VKDLREVIEEARQRRSAGRRTILFIDEI-------------- 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257743172 199 sRRL-KS--EFLIQF--DGvtsnpddLVIIIGAT--NkPQ-ELDDAVLRRLvkRIYV--PLPDSNVRKLLFK--TKLKCQ 266
Cdd:PRK13342 102 -HRFnKAqqDALLPHveDG-------TITLIGATteN-PSfEVNPALLSRA--QVFElkPLSEEDIEQLLKRalEDKERG 170

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 257743172 267 PHSLSDGDIDKIVKetegYSGSDLQA---LCEEAAMMPIrELGANILTIQANKvRSLRYD 323
Cdd:PRK13342 171 LVELDDEALDALAR----LANGDARRalnLLELAALGVD-SITLELLEEALQK-RAARYD 224
RecA-like_BCS1 cd19510
Mitochondrial chaperone BCS1; Mitochondrial chaperone BCS1 is necessary for the assembly of ...
 117-247 2.33e-11

Mitochondrial chaperone BCS1; Mitochondrial chaperone BCS1 is necessary for the assembly of mitochondrial respiratory chain complex III and plays an important role in the maintenance of mitochondrial tubular networks, respiratory chain assembly and formation of the LETM1 complex. RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410918 [Multi-domain]  Cd Length: 153  Bit Score: 61.21  E-value: 2.33e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257743172 117 RGLLLFGPPGNGKTMLAKAVASESQATF--FNVSASSLTSkwvgeaeKLVKTLFQVAisRQPSVIFMDEIDSIMSTRS-- 192
Cdd:cd19510   24 RGYLLYGPPGTGKSSFIAALAGELDYDIcdLNLSEVVLTD-------DRLNHLLNTA--PKQSIILLEDIDAAFESREhn 94

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 257743172 193 ----TSENEASRRLKSEFLIQFDGVTSNpdDLVIIIGATNKPQELDDAVLR--RLVKRIYV 247
Cdd:cd19510   95 kknpSAYGGLSRVTFSGLLNALDGVASS--EERIVFMTTNHIERLDPALIRpgRVDMKIYM 153
AAA_lid_3 pfam17862
AAA+ lid domain; This entry represents the alpha helical AAA+ lid domain that is found to the ...
 274-309 3.90e-11

AAA+ lid domain; This entry represents the alpha helical AAA+ lid domain that is found to the C-terminus of AAA domains.


Pssm-ID: 465537 [Multi-domain]  Cd Length: 45  Bit Score: 57.55  E-value: 3.90e-11
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 257743172  274 DIDKIVKETEGYSGSDLQALCEEAAMMPIRELGANI 309
Cdd:pfam17862   3 DLEELAERTEGFSGADLEALCREAALAALRRGLEAV 38
RecA-like_ATAD3-like cd19512
ATPase domains of ATPase AAA-domain protein 3A (ATAD3A), -3B, and -3C, and similar ATPase ...
 113-241 3.15e-10

ATPase domains of ATPase AAA-domain protein 3A (ATAD3A), -3B, and -3C, and similar ATPase domains; ATPase AAA-domain protein 3 (ATAD3) is a ubiquitously expressed mitochondrial protein involved in mitochondrial dynamics, DNA-nucleoid structural organization, cholesterol transport and steroidogenesis. The ATAD3 gene family in human comprises three paralog genes: ATAD3A, ATAD3B and ATAD3C. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410920 [Multi-domain]  Cd Length: 150  Bit Score: 57.92  E-value: 3.15e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257743172 113 RRPARGLLLFGPPGNGKTMLAKAVASESQATFFNVSASSLTSKWVGEAEKLVKTLFQVAISRQPSVIFMDEIDSIMSTRS 192
Cdd:cd19512   19 KGLYRNILFYGPPGTGKTLFAKKLALHSGMDYAIMTGGDVAPMGREGVTAIHKVFDWANTSRRGLLLFVDEADAFLRKRS 98

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 257743172 193 TSE-NEASRRLKSEFLIQfdgvTSNPDDLVIIIGATNKPQELDDAVLRRL 241
Cdd:cd19512   99 TEKiSEDLRAALNAFLYR----TGEQSNKFMLVLASNQPEQFDWAINDRI 144
RarA COG2256
Replication-associated recombination protein RarA (DNA-dependent ATPase) [Replication, ...
 119-323 1.37e-08

Replication-associated recombination protein RarA (DNA-dependent ATPase) [Replication, recombination and repair];


Pssm-ID: 441857 [Multi-domain]  Cd Length: 439  Bit Score: 55.83  E-value: 1.37e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257743172 119 LLLFGPPGNGKTMLAKAVASESQATFFNVSASslTSKwVGEAEKLVKTLFQVAISRQPSVIFMDEIDsimstrstsenea 198
Cdd:COG2256   52 MILWGPPGTGKTTLARLIANATDAEFVALSAV--TSG-VKDIREVIEEARERRAYGRRTILFVDEIH------------- 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257743172 199 srRL-KSE---FLiqfdgvtsnP---DDLVIIIGAT--NKPQELDDAVLRRLvkRIYV--PLPDSNVRKLL------FKT 261
Cdd:COG2256  116 --RFnKAQqdaLL---------PhveDGTITLIGATteNPSFEVNSALLSRC--RVFVlkPLSEEDLEQLLeraladDER 182

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257743172 262 KLKCQPHSLSDGDIDKIVketeGYSGSD----LQALcEEAAMMPiRELGANILTI----QANKVRSLRYD 323
Cdd:COG2256  183 GLGGYKLELDDEALEALA----RLADGDarraLNAL-ELAVLSA-PPDGVIEITLelveEALQRRALRYD 246
T7SS_EccA TIGR03922
type VII secretion AAA-ATPase EccA; This model represents the AAA family ATPase, EccA, of the ...
 87-248 1.43e-06

type VII secretion AAA-ATPase EccA; This model represents the AAA family ATPase, EccA, of the actinobacterial flavor of type VII secretion systems. Species such as Mycobacterium tuberculosis have several instances of this system per genome, designated EccA1, EccA2, etc. [Protein fate, Protein and peptide secretion and trafficking]


Pssm-ID: 188437 [Multi-domain]  Cd Length: 557  Bit Score: 49.84  E-value: 1.43e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257743172   87 GLNGAKQAL------LEMVILPAKRrdlftGLRRP--ARGLLLFGPPGNGKTMLAKAVASE-------SQATFFNVSASS 151
Cdd:TIGR03922 280 GLERVKRQVaalkssTAMALARAER-----GLPVAqtSNHMLFAGPPGTGKTTIARVVAKIycglgvlRKPLVREVSRAD 354

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257743172  152 LTSKWVGEAEKLVKTLFQVAISRqpsVIFMDEIDSIMSTRSTSENEASRRLKSEFLIQFDgvtSNPDDLVIIIG----AT 227
Cdd:TIGR03922 355 LIGQYIGESEAKTNEIIDSALGG---VLFLDEAYTLVETGYGQKDPFGLEAIDTLLARME---NDRDRLVVIGAgyrkDL 428

                         170       180
                  ....*....|....*....|.
gi 257743172  228 NKPQELDDAVLRRLVKRIYVP 248
Cdd:TIGR03922 429 DKFLEVNEGLRSRFTRVIEFP 449
RecA-like_HslU cd19498
ATP-dependent protease ATPase subunit HslU; HslU is a component of the ATP-dependent protease ...
 104-200 3.90e-06

ATP-dependent protease ATPase subunit HslU; HslU is a component of the ATP-dependent protease HslVU. In HslVU, HslU ATPase serves to unfold and translocate protein substrate, and the HslV protease degrades the unfolded proteins. This RecA-like_HslU subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410906 [Multi-domain]  Cd Length: 183  Bit Score: 46.60  E-value: 3.90e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257743172 104 KRRDLFTGLRRPA--RGLLLFGPPGNGKTMLAKAVASESQATFFNVSASSLTS-KWVG-EAEKLVKTLFQvaisrqpSVI 179
Cdd:cd19498   32 RRMQLPEELRDEVtpKNILMIGPTGVGKTEIARRLAKLAGAPFIKVEATKFTEvGYVGrDVESIIRDLVE-------GIV 104

                         90       100
                 ....*....|....*....|.
gi 257743172 180 FMDEIDSIMSTRSTSENEASR 200
Cdd:cd19498  105 FIDEIDKIAKRGGSSGPDVSR 125
MoxR COG0714
MoxR-like ATPase [General function prediction only]; MoxR-like ATPase is part of the Pathway ...
 106-251 7.33e-06

MoxR-like ATPase [General function prediction only]; MoxR-like ATPase is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 440478 [Multi-domain]  Cd Length: 292  Bit Score: 47.08  E-value: 7.33e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257743172 106 RDLFTGLRrpARG-LLLFGPPGNGKTMLAKAVASESQATFFNVSASS--LTSKWVGE--------AEKLVK-TLFQvais 173
Cdd:COG0714   22 ELVLIALL--AGGhLLLEGVPGVGKTTLAKALARALGLPFIRIQFTPdlLPSDILGTyiydqqtgEFEFRPgPLFA---- 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257743172 174 rqpSVIFMDEIDS-----------IMSTRS-TSENEaSRRLKSEFLiqfdgV--TSNPDDLViiigATNkpqELDDAVLR 239
Cdd:COG0714   96 ---NVLLADEINRappktqsalleAMEERQvTIPGG-TYKLPEPFL-----ViaTQNPIEQE----GTY---PLPEAQLD 159

                        170
                 ....*....|..
gi 257743172 240 RLVKRIYVPLPD 251
Cdd:COG0714  160 RFLLKLYIGYPD 171
PRK04195 PRK04195
replication factor C large subunit; Provisional
 83-295 8.45e-06

replication factor C large subunit; Provisional


Pssm-ID: 235250 [Multi-domain]  Cd Length: 482  Bit Score: 47.22  E-value: 8.45e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257743172  83 DDVAGLNGAKQALLEMVILPAKRRdlftglrrPARGLLLFGPPGNGKTMLAKAVASEsqatfFNV-----------SASS 151
Cdd:PRK04195  14 SDVVGNEKAKEQLREWIESWLKGK--------PKKALLLYGPPGVGKTSLAHALAND-----YGWevielnasdqrTADV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257743172 152 LtSKWVGEAEKlVKTLFqvAISRQpsVIFMDEIDSImstrstSENE----ASRRLKsefLIQfdgVTSNPddlvIIIGAt 227
Cdd:PRK04195  81 I-ERVAGEAAT-SGSLF--GARRK--LILLDEVDGI------HGNEdrggARAILE---LIK---KAKQP----IILTA- 137

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 257743172 228 NKPQELDDAVLRRLVKRI-YVPLPDSNVRKLLFKT----KLKCqphslSDGDIDKIVKETEG---YSGSDLQALCE 295
Cdd:PRK04195 138 NDPYDPSLRELRNACLMIeFKRLSTRSIVPVLKRIcrkeGIEC-----DDEALKEIAERSGGdlrSAINDLQAIAE 208
AAA_2 pfam07724
AAA domain (Cdc48 subfamily); This Pfam entry includes some of the AAA proteins not detected ...
 120-187 1.55e-04

AAA domain (Cdc48 subfamily); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.


Pssm-ID: 400187 [Multi-domain]  Cd Length: 168  Bit Score: 41.80  E-value: 1.55e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257743172  120 LLFGPPGNGKTMLAKAVASE---SQATFFNVSASSLT-----SKWVGEAEKLVK-----TLFQVAISRQPSVIFMDEIDS 186
Cdd:pfam07724   7 LFLGPTGVGKTELAKALAELlfgDERALIRIDMSEYMeehsvSRLIGAPPGYVGyeeggQLTEAVRRKPYSIVLIDEIEK 86


                  .
gi 257743172  187 I 187
Cdd:pfam07724  87 A 87
RecA-like_ClpB_Hsp104-like cd19499
Chaperone protein ClpB/Hsp104 subfamily; Bacterial Caseinolytic peptidase B (ClpB) and ...
 85-185 3.47e-04

Chaperone protein ClpB/Hsp104 subfamily; Bacterial Caseinolytic peptidase B (ClpB) and eukaryotic Heat shock protein 104 (Hsp104) are ATP-dependent molecular chaperones and essential proteins of the heat-shock response. ClpB/Hsp104 ATPases, in concert with the DnaK/Hsp70 chaperone system, disaggregate and reactivate aggregated proteins. This RecA-like_ClpB_Hsp104_like subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410907 [Multi-domain]  Cd Length: 178  Bit Score: 41.01  E-value: 3.47e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257743172  85 VAGLNGAKQALLEMVILPAkrrdlfTGLRRPARG---LLLFGPPGNGKTMLAKAVA-----SESQATFFNVSA------- 149
Cdd:cd19499   13 VVGQDEAVKAVSDAIRRAR------AGLSDPNRPigsFLFLGPTGVGKTELAKALAellfgDEDNLIRIDMSEymekhsv 86

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 257743172 150 SSLTSKWVGEAEKLVKTLFQVAISRQP-SVIFMDEID 185
Cdd:cd19499   87 SRLIGAPPGYVGYTEGGQLTEAVRRKPySVVLLDEIE 123
clpX PRK05342
ATP-dependent Clp protease ATP-binding subunit ClpX;
120-196 4.66e-04

ATP-dependent Clp protease ATP-binding subunit ClpX;


Pssm-ID: 235422 [Multi-domain]  Cd Length: 412  Bit Score: 41.68  E-value: 4.66e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257743172 120 LLFGPPGNGKTMLAKAVASESQATFFNVSASSLT-SKWVGE-AEKLVKTLFQVA---ISR-QPSVIFMDEIDSImsTRSt 193
Cdd:PRK05342 112 LLIGPTGSGKTLLAQTLARILDVPFAIADATTLTeAGYVGEdVENILLKLLQAAdydVEKaQRGIVYIDEIDKI--ARK- 188


                 ...
gi 257743172 194 SEN 196
Cdd:PRK05342 189 SEN 191
PRK08116 PRK08116
hypothetical protein; Validated
 109-139 5.91e-04

hypothetical protein; Validated


Pssm-ID: 236153 [Multi-domain]  Cd Length: 268  Bit Score: 41.16  E-value: 5.91e-04
                         10        20        30
                 ....*....|....*....|....*....|.
gi 257743172 109 FTGLRRPARGLLLFGPPGNGKTMLAKAVASE 139
Cdd:PRK08116 107 FEEMKKENVGLLLWGSVGTGKTYLAACIANE 137
PRK09862 PRK09862
ATP-dependent protease;
119-156 6.52e-04

ATP-dependent protease;


Pssm-ID: 182120 [Multi-domain]  Cd Length: 506  Bit Score: 41.50  E-value: 6.52e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 257743172 119 LLLFGPPGNGKTMLAKAV-----------ASESQATFFNVSASSLTSKW 156
Cdd:PRK09862 213 LLLIGPPGTGKTMLASRIngllpdlsneeALESAAILSLVNAESVQKQW 261
RecA-like_Lon cd19500
lon protease homolog 2 peroxisomal; Lon protease (also known as Lon peptidase) is an ...
 119-187 8.52e-04

lon protease homolog 2 peroxisomal; Lon protease (also known as Lon peptidase) is an evolutionarily conserved ATP-dependent serine protease, present in bacteria and eukaryotic mitochondria and peroxisomes, which mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Lon protease is both an ATP-dependent peptidase and a protein-activated ATPase. This RecA-like Lon domain subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410908 [Multi-domain]  Cd Length: 182  Bit Score: 39.85  E-value: 8.52e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257743172 119 LLLFGPPGNGKTMLAKAVASESQATFFNVSASSLTSkwvgEAE--------------KLVKTLFQVAiSRQPsVIFMDEI 184
Cdd:cd19500   40 LCLVGPPGVGKTSLGKSIARALGRKFVRISLGGVRD----EAEirghrrtyvgampgRIIQALKKAG-TNNP-VFLLDEI 113


                 ...
gi 257743172 185 DSI 187
Cdd:cd19500  114 DKI 116
Vps4_C pfam09336
Vps4 C terminal oligomerization domain; This domain is found at the C terminal of ATPase ...
 312-352 9.35e-04

Vps4 C terminal oligomerization domain; This domain is found at the C terminal of ATPase proteins involved in vacuolar sorting. It forms an alpha helix structure and is required for oligomerization.


Pssm-ID: 462762 [Multi-domain]  Cd Length: 61  Bit Score: 37.09  E-value: 9.35e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 257743172  312 IQANKV--RSLRYDDFRKSMAVIRPSLSKSKWEELERWNSEFG 352
Cdd:pfam09336  19 IPSDKLlePPVTMKDFLKALKSSRPTVSKEDLEKYEEFTKEFG 61
TIP49 pfam06068
TIP49 P-loop domain; This family consists of the C-terminal region of several eukaryotic and ...
 117-285 9.50e-04

TIP49 P-loop domain; This family consists of the C-terminal region of several eukaryotic and archaeal RuvB-like 1 (Pontin or TIP49a) and RuvB-like 2 (Reptin or TIP49b) proteins. The N-terminal domain contains the pfam00004 domain. In zebrafish, the liebeskummer (lik) mutation, causes development of hyperplastic embryonic hearts. lik encodes Reptin, a component of a DNA-stimulated ATPase complex. Beta-catenin and Pontin, a DNA-stimulated ATPase that is often part of complexes with Reptin, are in the same genetic pathways. The Reptin/Pontin ratio serves to regulate heart growth during development, at least in part via the beta-catenin pathway. TBP-interacting protein 49 (TIP49) was originally identified as a TBP-binding protein, and two related proteins are encoded by individual genes, tip49a and b. Although the function of this gene family has not been elucidated, they are supposed to play a critical role in nuclear events because they interact with various kinds of nuclear factors and have DNA helicase activities.TIP49a has been suggested to act as an autoantigen in some patients with autoimmune diseases.


Pssm-ID: 399217 [Multi-domain]  Cd Length: 347  Bit Score: 40.76  E-value: 9.50e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257743172  117 RGLLLFGPPGNGKTMLAKAVASE-SQATFFN-VSASSLTSKWVGEAEKLVKTLFQ---VAISRQPSVI---------FMD 182
Cdd:pfam06068  51 RAVLIAGPPGTGKTALAIAISKElGEDTPFTsISGSEVYSLEMKKTEALTQAFRKaigVRIKEEKEVYegevveleiEEA 130

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257743172  183 E--------IDSIMSTRSTSENEASRRLKSEFLIQFDGVTSNPDDLVIIIGATNKPQELDDAVLRR----LVKRIYVPLP 250
Cdd:pfam06068 131 EnplsggktIKGGKITLKTTKMEKTLKLGPKIYEQLQKEKVSAGDVIYIDKNTGRVKKLGRSFARAtdfdLEATEFVPCP 210

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 257743172  251 DSNVRkllfktKLKCQPHSLSDGDIDKIVKETEGY 285
Cdd:pfam06068 211 KGEVH------KRKEVVQTVTLHDIDVANARPQGI 239
RuvB_N pfam05496
Holliday junction DNA helicase RuvB P-loop domain; The RuvB protein makes up part of the ...
 81-184 1.07e-03

Holliday junction DNA helicase RuvB P-loop domain; The RuvB protein makes up part of the RuvABC revolvasome which catalyzes the resolution of Holliday junctions that arise during genetic recombination and DNA repair. Branch migration is catalyzed by the RuvB protein that is targeted to the Holliday junction by the structure specific RuvA protein. This family contains the N-terminal region of the protein.


Pssm-ID: 398900 [Multi-domain]  Cd Length: 159  Bit Score: 39.02  E-value: 1.07e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257743172   81 KWDDVAGLNGAKQALlEMVILPAKRRDlftglrRPARGLLLFGPPGNGKTMLAKAVASESQATFFNVSASSLTSKwvGEA 160
Cdd:pfam05496   5 TLDEYIGQEKVKENL-KIFIEAAKQRG------EALDHVLLYGPPGLGKTTLANIIANEMGVNIRITSGPAIERP--GDL 75

                          90       100
                  ....*....|....*....|....*
gi 257743172  161 EKLVKTLfqvaisrQP-SVIFMDEI 184
Cdd:pfam05496  76 AAILTNL-------EPgDVLFIDEI 93
Mg_chelatase pfam01078
Magnesium chelatase, subunit ChlI; Magnesium-chelatase is a three-component enzyme that ...
 119-138 1.31e-03

Magnesium chelatase, subunit ChlI; Magnesium-chelatase is a three-component enzyme that catalyzes the insertion of Mg2+ into protoporphyrin IX. This is the first unique step in the synthesis of (bacterio)chlorophyll. Due to this, it is thought that Mg-chelatase has an important role in channelling inter- mediates into the (bacterio)chlorophyll branch in response to conditions suitable for photosynthetic growth. ChlI and BchD have molecular weight between 38-42 kDa.


Pssm-ID: 426032 [Multi-domain]  Cd Length: 207  Bit Score: 39.44  E-value: 1.31e-03
                          10        20
                  ....*....|....*....|
gi 257743172  119 LLLFGPPGNGKTMLAKAVAS 138
Cdd:pfam01078  25 LLMIGPPGSGKTMLAKRLPG 44
AAA_5 pfam07728
AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not ...
 118-241 1.52e-03

AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.


Pssm-ID: 400191 [Multi-domain]  Cd Length: 135  Bit Score: 38.43  E-value: 1.52e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257743172  118 GLLLFGPPGNGKTMLAKAVASE-SQATFFNV------SASSLTSKWV--GEAEKLVKTLFqVAISRQPSVIFMDEID--- 185
Cdd:pfam07728   1 GVLLVGPPGTGKTELAERLAAAlSNRPVFYVqltrdtTEEDLFGRRNidPGGASWVDGPL-VRAAREGEIAVLDEINran 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 257743172  186 --------SIMSTRSTSENEASRRLKSefliqfdgvtsnPDDLVIIIGATNKP----QELDDAVLRRL 241
Cdd:pfam07728  80 pdvlnsllSLLDERRLLLPDGGELVKA------------APDGFRLIATMNPLdrglNELSPALRSRF 135
ABC_ATPase cd00267
ATP-binding cassette transporter nucleotide-binding domain; ABC transporters are a large ...
 119-186 1.58e-03

ATP-binding cassette transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide-binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.


Pssm-ID: 213179 [Multi-domain]  Cd Length: 157  Bit Score: 38.77  E-value: 1.58e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257743172 119 LLLFGPPGNGKTMLAKAVA-----SESQATFFNVSASSLTSKwvgEAEKLVKTLFQ--------VAISR----QPSVIFM 181
Cdd:cd00267   28 VALVGPNGSGKSTLLRAIAgllkpTSGEILIDGKDIAKLPLE---ELRRRIGYVPQlsggqrqrVALARalllNPDLLLL 104


                 ....*
gi 257743172 182 DEIDS 186
Cdd:cd00267  105 DEPTS 109
TIP49 COG1224
DNA helicase TIP49, TBP-interacting protein [Transcription];
117-167 1.64e-03

DNA helicase TIP49, TBP-interacting protein [Transcription];


Pssm-ID: 440837 [Multi-domain]  Cd Length: 452  Bit Score: 39.95  E-value: 1.64e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 257743172 117 RGLLLFGPPGNGKTMLAKAVASE--SQATFFNVSASSLTSKWVGEAEKLVKTL 167
Cdd:COG1224   65 KGILIVGPPGTGKTALAVAIARElgEDTPFVAISGSEIYSAELKKTEFLMQAL 117
44 PHA02544
clamp loader, small subunit; Provisional
 96-204 1.83e-03

clamp loader, small subunit; Provisional


Pssm-ID: 222866 [Multi-domain]  Cd Length: 316  Bit Score: 39.59  E-value: 1.83e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257743172  96 LEMVILPAKRRDLFTGLRRPAR--GLLLFGP-PGNGKTMLAKAVASESQATFFNVSASSLTSKWV-GEAEKLVKTlfqVA 171
Cdd:PHA02544  20 IDECILPAADKETFKSIVKKGRipNMLLHSPsPGTGKTTVAKALCNEVGAEVLFVNGSDCRIDFVrNRLTRFAST---VS 96

                         90       100       110
                 ....*....|....*....|....*....|...
gi 257743172 172 ISRQPSVIFMDEIDsimstrSTSENEASRRLKS 204
Cdd:PHA02544  97 LTGGGKVIIIDEFD------RLGLADAQRHLRS 123
YifB COG0606
Predicted Mg-chelatase, contains ChlI-like and ATPase domains, YifB family [Posttranslational ...
 119-138 2.77e-03

Predicted Mg-chelatase, contains ChlI-like and ATPase domains, YifB family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440371 [Multi-domain]  Cd Length: 502  Bit Score: 39.64  E-value: 2.77e-03
                         10        20
                 ....*....|....*....|
gi 257743172 119 LLLFGPPGNGKTMLAKAVAS 138
Cdd:COG0606  214 LLMIGPPGSGKTMLARRLPG 233
ruvB PRK00080
Holliday junction branch migration DNA helicase RuvB;
119-184 3.89e-03

Holliday junction branch migration DNA helicase RuvB;


Pssm-ID: 234619 [Multi-domain]  Cd Length: 328  Bit Score: 38.57  E-value: 3.89e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 257743172 119 LLLFGPPGNGKTMLAKAVASESQATFFNVSASSLtskwvgeaEK---LvktlfqVAI--SRQP-SVIFMDEI 184
Cdd:PRK00080  54 VLLYGPPGLGKTTLANIIANEMGVNIRITSGPAL--------EKpgdL------AAIltNLEEgDVLFIDEI 111
PRK13341 PRK13341
AAA family ATPase;
119-149 4.30e-03

AAA family ATPase;


Pssm-ID: 237354 [Multi-domain]  Cd Length: 725  Bit Score: 38.88  E-value: 4.30e-03
                         10        20        30
                 ....*....|....*....|....*....|.
gi 257743172 119 LLLFGPPGNGKTMLAKAVASESQATFFNVSA 149
Cdd:PRK13341  55 LILYGPPGVGKTTLARIIANHTRAHFSSLNA 85
DnaC COG1484
DNA replication protein DnaC [Replication, recombination and repair];
114-139 5.55e-03

DNA replication protein DnaC [Replication, recombination and repair];


Pssm-ID: 441093 [Multi-domain]  Cd Length: 242  Bit Score: 37.84  E-value: 5.55e-03
                         10        20
                 ....*....|....*....|....*.
gi 257743172 114 RPARGLLLFGPPGNGKTMLAKAVASE 139
Cdd:COG1484   97 ERGENLILLGPPGTGKTHLAIALGHE 122
IS21_help_AAA NF038214
IS21-like element helper ATPase IstB; This protein family model resembles PF01695, but was ...
 102-137 8.42e-03

IS21-like element helper ATPase IstB; This protein family model resembles PF01695, but was built to hit full-length AAA+ ATPases of IS21 family IS (insertion sequence) elements.


Pssm-ID: 439516  Cd Length: 232  Bit Score: 37.45  E-value: 8.42e-03
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 257743172 102 PAKRRDLFTG--LRRpARGLLLFGPPGNGKTMLAKAVA 137
Cdd:NF038214  75 KAQIRELATLdfIER-AENVLLLGPPGTGKTHLAIALG 111
PRK12422 PRK12422
chromosomal replication initiator protein DnaA;
121-258 8.73e-03

chromosomal replication initiator protein DnaA;


Pssm-ID: 183521 [Multi-domain]  Cd Length: 445  Bit Score: 37.89  E-value: 8.73e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257743172 121 LFGPPGNGKTMLAKAVAS---ESQATFFNVSASSLTSKWVGEAEKLVKTLFQVAIsRQPSVIFMDEIDSIMSTRSTSEne 197
Cdd:PRK12422 146 LFGPEGSGKTHLMQAAVHalrESGGKILYVRSELFTEHLVSAIRSGEMQRFRQFY-RNVDALFIEDIEVFSGKGATQE-- 222

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 257743172 198 asrrlksEFLIQFDGVTSnpDDLVIIIGATNKPQELdDAVLRRLVKR----IYV---PLPDSNVRKLL 258
Cdd:PRK12422 223 -------EFFHTFNSLHT--EGKLIVISSTCAPQDL-KAMEERLISRfewgIAIplhPLTKEGLRSFL 280
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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