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Conserved domains on  [gi|300599553|emb|CBV35639|]
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unnamed protein product [Schizosaccharomyces pombe]

Protein Classification

class I SAM-dependent methyltransferase family protein( domain architecture ID 1001310)

class I SAM-dependent methyltransferase family protein that catalyzes the transfer of the methyl or the alpha-amino-alpha-carboxypropyl (acp) group from S-adenosyl-L-methionine (SAM or AdoMet) to one or more specific substrates; similar to tRNA (guanine(37)-N1)-methyltransferase and tRNA wybutosine-synthesizing protein 2 homolog

EC:  2.-.-.-
Gene Ontology:  GO:0008175|GO:0030488
PubMed:  12826405|12504684

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Trm5 super family cl34477
tRNA G37 N-methylase Trm5 [Translation, ribosomal structure and biogenesis]; tRNA G37 ...
226-415 2.68e-16

tRNA G37 N-methylase Trm5 [Translation, ribosomal structure and biogenesis]; tRNA G37 N-methylase Trm5 is part of the Pathway/BioSystem: tRNA modification


The actual alignment was detected with superfamily member COG2520:

Pssm-ID: 442010 [Multi-domain]  Cd Length: 333  Bit Score: 79.52  E-value: 2.68e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300599553 226 MFSRGNSIEKARVLnfSYIKD-EIIADLYAGIGYFTFSYVKAGASTVFCWEINPWSVEALRRAALKNgwsiyvvrngeny 304
Cdd:COG2520  162 YFSPRLATERLRIA--ELVKPgERVLDMFAGVGPFSIPIAKRSGAKVVAIDINPDAVEYLKENIRLN------------- 226
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300599553 305 efKVGtHRIVVFLESNVYAAERFSK------MNisarhinlgmLP-SSEKSWSTATSILKREShsFIHVHENVKDED-IE 376
Cdd:COG2520  227 --KVE-DRVTPILGDAREVAPELEGkadriiMN----------LPhSADEFLDAALRALKPGG--VIHYYEIVPEEDpFE 291
                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 300599553 377 TYSSEVNSCFSKMLAKNTVCVTNCVKSFSPRVSHIVYDI 415
Cdd:COG2520  292 RAEERIEEAAEEAGYEVEILEKRRVKSYSPGVYHVVVDV 330
 
Name Accession Description Interval E-value
Trm5 COG2520
tRNA G37 N-methylase Trm5 [Translation, ribosomal structure and biogenesis]; tRNA G37 ...
226-415 2.68e-16

tRNA G37 N-methylase Trm5 [Translation, ribosomal structure and biogenesis]; tRNA G37 N-methylase Trm5 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 442010 [Multi-domain]  Cd Length: 333  Bit Score: 79.52  E-value: 2.68e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300599553 226 MFSRGNSIEKARVLnfSYIKD-EIIADLYAGIGYFTFSYVKAGASTVFCWEINPWSVEALRRAALKNgwsiyvvrngeny 304
Cdd:COG2520  162 YFSPRLATERLRIA--ELVKPgERVLDMFAGVGPFSIPIAKRSGAKVVAIDINPDAVEYLKENIRLN------------- 226
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300599553 305 efKVGtHRIVVFLESNVYAAERFSK------MNisarhinlgmLP-SSEKSWSTATSILKREShsFIHVHENVKDED-IE 376
Cdd:COG2520  227 --KVE-DRVTPILGDAREVAPELEGkadriiMN----------LPhSADEFLDAALRALKPGG--VIHYYEIVPEEDpFE 291
                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 300599553 377 TYSSEVNSCFSKMLAKNTVCVTNCVKSFSPRVSHIVYDI 415
Cdd:COG2520  292 RAEERIEEAAEEAGYEVEILEKRRVKSYSPGVYHVVVDV 330
Met_10 pfam02475
Met-10+ like-protein; The methionine-10 mutant allele of N. crassa codes for a protein of ...
226-306 4.38e-05

Met-10+ like-protein; The methionine-10 mutant allele of N. crassa codes for a protein of unknown function, Swiss:O27901. However, homologous proteins have been found in yeast suggesting this protein may be involved in methionine biosynthesis, transport and/or utilization.


Pssm-ID: 396850 [Multi-domain]  Cd Length: 198  Bit Score: 44.27  E-value: 4.38e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300599553  226 MFSRGNSIEKARVLNFSYiKDEIIADLYAGIGYFTFSYVKAG-ASTVFCWEINPWSVEALRRAALKNGWSIYVVR-NGEN 303
Cdd:pfam02475  81 YWSPRLIAERERIAKLVE-PGEVVVDMFAGIGPFSIPIAKHSkARRVYAIELNPESYKYLKENIKLNKVEDVVKPiLGDV 159

                  ...
gi 300599553  304 YEF 306
Cdd:pfam02475 160 REV 162
 
Name Accession Description Interval E-value
Trm5 COG2520
tRNA G37 N-methylase Trm5 [Translation, ribosomal structure and biogenesis]; tRNA G37 ...
226-415 2.68e-16

tRNA G37 N-methylase Trm5 [Translation, ribosomal structure and biogenesis]; tRNA G37 N-methylase Trm5 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 442010 [Multi-domain]  Cd Length: 333  Bit Score: 79.52  E-value: 2.68e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300599553 226 MFSRGNSIEKARVLnfSYIKD-EIIADLYAGIGYFTFSYVKAGASTVFCWEINPWSVEALRRAALKNgwsiyvvrngeny 304
Cdd:COG2520  162 YFSPRLATERLRIA--ELVKPgERVLDMFAGVGPFSIPIAKRSGAKVVAIDINPDAVEYLKENIRLN------------- 226
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300599553 305 efKVGtHRIVVFLESNVYAAERFSK------MNisarhinlgmLP-SSEKSWSTATSILKREShsFIHVHENVKDED-IE 376
Cdd:COG2520  227 --KVE-DRVTPILGDAREVAPELEGkadriiMN----------LPhSADEFLDAALRALKPGG--VIHYYEIVPEEDpFE 291
                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 300599553 377 TYSSEVNSCFSKMLAKNTVCVTNCVKSFSPRVSHIVYDI 415
Cdd:COG2520  292 RAEERIEEAAEEAGYEVEILEKRRVKSYSPGVYHVVVDV 330
COG4076 COG4076
Predicted RNA methylase [General function prediction only];
245-294 3.45e-05

Predicted RNA methylase [General function prediction only];


Pssm-ID: 443253 [Multi-domain]  Cd Length: 230  Bit Score: 45.03  E-value: 3.45e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 300599553 245 KDEIIADLYAGIGYFTFSYVKAGASTVFCWEINPWSVEALRRAALKNGWS 294
Cdd:COG4076   35 PGDVVLDIGTGSGLLSMLAARAGAKKVYAVEVNPDIAAVARRIIAANGLS 84
TrmA COG2265
tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure ...
245-309 3.76e-05

tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure and biogenesis]; tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 441866 [Multi-domain]  Cd Length: 377  Bit Score: 45.55  E-value: 3.76e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 300599553 245 KDEIIADLYAGIGYFTFSYVKAGAStVFCWEINPWSVEALRRAALKNGWsiyvvrngENYEFKVG 309
Cdd:COG2265  233 GGERVLDLYCGVGTFALPLARRAKK-VIGVEIVPEAVEDARENARLNGL--------KNVEFVAG 288
Met_10 pfam02475
Met-10+ like-protein; The methionine-10 mutant allele of N. crassa codes for a protein of ...
226-306 4.38e-05

Met-10+ like-protein; The methionine-10 mutant allele of N. crassa codes for a protein of unknown function, Swiss:O27901. However, homologous proteins have been found in yeast suggesting this protein may be involved in methionine biosynthesis, transport and/or utilization.


Pssm-ID: 396850 [Multi-domain]  Cd Length: 198  Bit Score: 44.27  E-value: 4.38e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300599553  226 MFSRGNSIEKARVLNFSYiKDEIIADLYAGIGYFTFSYVKAG-ASTVFCWEINPWSVEALRRAALKNGWSIYVVR-NGEN 303
Cdd:pfam02475  81 YWSPRLIAERERIAKLVE-PGEVVVDMFAGIGPFSIPIAKHSkARRVYAIELNPESYKYLKENIKLNKVEDVVKPiLGDV 159

                  ...
gi 300599553  304 YEF 306
Cdd:pfam02475 160 REV 162
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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