NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|301158147|emb|CBW17644|]
View 

aminoglycoside 6'-N-acetyltransferase [Salmonella enterica subsp. enterica serovar Typhimurium str. SL1344]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
AAC_6p_Salmo NF000140
AAC(6')-Iy/Iaa family aminoglycoside 6'-N-acetyltransferase; Members of this family are ...
 1-145 4.58e-107

AAC(6')-Iy/Iaa family aminoglycoside 6'-N-acetyltransferase; Members of this family are chromosomal acetyltransferases from the genus Salmonella. Analysis has demonstrated a case in which a member designated AAC(6')-Iy, identical in two different strains isolated from a single patient, conferred resistance to tobramycin only in the isolate where a deletion event upstream of the gene resulted in high expression. Members of this family are therefore considered cryptic aminoglycoside N-acetyltransferases. which may or may not confer resistance, depending on expression levels.


:

Pssm-ID: 411079  Cd Length: 145  Bit Score: 300.82  E-value: 4.58e-107
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301158147   1 MDIRQMNRTHLDHWRGLRKQLWPGHPDDAHLADGEEILQADHLASFIAMADGVAIGFADASIRHDYVNGCDSSPVVFLEG 80
Cdd:NF000140   1 MDIRQMNKTHLEHWRGLRKQLWPGHPDDAHLADGEEILQADHLASFIAMADGVAIGFADASIRHDYVNGCDSSPVAFLEG 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 301158147  81 IFVLPSFRQRGVAKQLIAAVQRWGTNKGCREMASDTSPENTISQKVHQALGFEETERVIFYRKRC 145
Cdd:NF000140  81 IFVLPSFRQRGVAKQLIAAVQRWGTNKGCREMASDTSPENTISQKVHQALGFEETERVIFYRKRC 145
 
Name Accession Description Interval E-value
AAC_6p_Salmo NF000140
AAC(6')-Iy/Iaa family aminoglycoside 6'-N-acetyltransferase; Members of this family are ...
 1-145 4.58e-107

AAC(6')-Iy/Iaa family aminoglycoside 6'-N-acetyltransferase; Members of this family are chromosomal acetyltransferases from the genus Salmonella. Analysis has demonstrated a case in which a member designated AAC(6')-Iy, identical in two different strains isolated from a single patient, conferred resistance to tobramycin only in the isolate where a deletion event upstream of the gene resulted in high expression. Members of this family are therefore considered cryptic aminoglycoside N-acetyltransferases. which may or may not confer resistance, depending on expression levels.


Pssm-ID: 411079  Cd Length: 145  Bit Score: 300.82  E-value: 4.58e-107
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301158147   1 MDIRQMNRTHLDHWRGLRKQLWPGHPDDAHLADGEEILQADHLASFIAMADGVAIGFADASIRHDYVNGCDSSPVVFLEG 80
Cdd:NF000140   1 MDIRQMNKTHLEHWRGLRKQLWPGHPDDAHLADGEEILQADHLASFIAMADGVAIGFADASIRHDYVNGCDSSPVAFLEG 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 301158147  81 IFVLPSFRQRGVAKQLIAAVQRWGTNKGCREMASDTSPENTISQKVHQALGFEETERVIFYRKRC 145
Cdd:NF000140  81 IFVLPSFRQRGVAKQLIAAVQRWGTNKGCREMASDTSPENTISQKVHQALGFEETERVIFYRKRC 145
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 14-132 2.11e-18

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 75.25  E-value: 2.11e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301158147   14 WRGLRKQLWPGHPDDAHLADGEEILQADHLAS---FIAMADGVAIGFADASIRHDYVngcdssPVVFLEGIFVLPSFRQR 90
Cdd:pfam00583   1 LEALYELLSEEFPEPWPDEPLDLLEDWDEDASegfFVAEEDGELVGFASLSIIDDEP------PVGEIEGLAVAPEYRGK 74

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 301158147   91 GVAKQLIAAVQRWGTNKGCREMASDTSPENTISQKVHQALGF 132
Cdd:pfam00583  75 GIGTALLQALLEWARERGCERIFLEVAADNLAAIALYEKLGF 116
MnaT COG1247
L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];
1-138 6.29e-18

L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];


Pssm-ID: 440860 [Multi-domain]  Cd Length: 163  Bit Score: 75.42  E-value: 6.29e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301158147   1 MDIRQMNRTHLDHWRGLRKQLWPGH--------PDDAHLADGEEILQADHLASFIAMADGVAIGFADASIrhdyVNGCDS 72
Cdd:COG1247    2 MTIRPATPEDAPAIAAIYNEAIAEGtatfetepPSEEEREAWFAAILAPGRPVLVAEEDGEVVGFASLGP----FRPRPA 77

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 301158147  73 SPVVFLEGIFVLPSFRQRGVAKQLIAAVQRWGTNKGCREMASDTSPENTISQKVHQALGFEETERV 138
Cdd:COG1247   78 YRGTAEESIYVDPDARGRGIGRALLEALIERARARGYRRLVAVVLADNEASIALYEKLGFEEVGTL 143
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 45-112 9.13e-09

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 48.81  E-value: 9.13e-09
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 301158147  45 SFIAMADGVAIGFADASIRHDyvngcdSSPVVFLEGIFVLPSFRQRGVAKQLIAAVQRWGTNKGCREM 112
Cdd:cd04301    1 FLVAEDDGEIVGFASLSPDGS------GGDTAYIGDLAVLPEYRGKGIGSALLEAAEEEARERGAKRL 62
PRK03624 PRK03624
putative acetyltransferase; Provisional
 83-140 8.03e-07

putative acetyltransferase; Provisional


Pssm-ID: 235142 [Multi-domain]  Cd Length: 140  Bit Score: 45.30  E-value: 8.03e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 301158147  83 VLPSFRQRGVAKQLIAAVQRWGTNKGCREMASDTSPENTISQKVHQALGFEETERVIF 140
Cdd:PRK03624  76 VHPDFRGRGIGRALVARLEKKLIARGCPKINLQVREDNDAVLGFYEALGYEEQDRISL 133
 
Name Accession Description Interval E-value
AAC_6p_Salmo NF000140
AAC(6')-Iy/Iaa family aminoglycoside 6'-N-acetyltransferase; Members of this family are ...
 1-145 4.58e-107

AAC(6')-Iy/Iaa family aminoglycoside 6'-N-acetyltransferase; Members of this family are chromosomal acetyltransferases from the genus Salmonella. Analysis has demonstrated a case in which a member designated AAC(6')-Iy, identical in two different strains isolated from a single patient, conferred resistance to tobramycin only in the isolate where a deletion event upstream of the gene resulted in high expression. Members of this family are therefore considered cryptic aminoglycoside N-acetyltransferases. which may or may not confer resistance, depending on expression levels.


Pssm-ID: 411079  Cd Length: 145  Bit Score: 300.82  E-value: 4.58e-107
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301158147   1 MDIRQMNRTHLDHWRGLRKQLWPGHPDDAHLADGEEILQADHLASFIAMADGVAIGFADASIRHDYVNGCDSSPVVFLEG 80
Cdd:NF000140   1 MDIRQMNKTHLEHWRGLRKQLWPGHPDDAHLADGEEILQADHLASFIAMADGVAIGFADASIRHDYVNGCDSSPVAFLEG 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 301158147  81 IFVLPSFRQRGVAKQLIAAVQRWGTNKGCREMASDTSPENTISQKVHQALGFEETERVIFYRKRC 145
Cdd:NF000140  81 IFVLPSFRQRGVAKQLIAAVQRWGTNKGCREMASDTSPENTISQKVHQALGFEETERVIFYRKRC 145
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 14-132 2.11e-18

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 75.25  E-value: 2.11e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301158147   14 WRGLRKQLWPGHPDDAHLADGEEILQADHLAS---FIAMADGVAIGFADASIRHDYVngcdssPVVFLEGIFVLPSFRQR 90
Cdd:pfam00583   1 LEALYELLSEEFPEPWPDEPLDLLEDWDEDASegfFVAEEDGELVGFASLSIIDDEP------PVGEIEGLAVAPEYRGK 74

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 301158147   91 GVAKQLIAAVQRWGTNKGCREMASDTSPENTISQKVHQALGF 132
Cdd:pfam00583  75 GIGTALLQALLEWARERGCERIFLEVAADNLAAIALYEKLGF 116
MnaT COG1247
L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];
1-138 6.29e-18

L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];


Pssm-ID: 440860 [Multi-domain]  Cd Length: 163  Bit Score: 75.42  E-value: 6.29e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301158147   1 MDIRQMNRTHLDHWRGLRKQLWPGH--------PDDAHLADGEEILQADHLASFIAMADGVAIGFADASIrhdyVNGCDS 72
Cdd:COG1247    2 MTIRPATPEDAPAIAAIYNEAIAEGtatfetepPSEEEREAWFAAILAPGRPVLVAEEDGEVVGFASLGP----FRPRPA 77

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 301158147  73 SPVVFLEGIFVLPSFRQRGVAKQLIAAVQRWGTNKGCREMASDTSPENTISQKVHQALGFEETERV 138
Cdd:COG1247   78 YRGTAEESIYVDPDARGRGIGRALLEALIERARARGYRRLVAVVLADNEASIALYEKLGFEEVGTL 143
PhnO COG0454
N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, ...
 25-142 1.02e-17

N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, General function prediction only];


Pssm-ID: 440222 [Multi-domain]  Cd Length: 136  Bit Score: 73.93  E-value: 1.02e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301158147  25 HPDDAHLADGEEILQA--------DHLASFIA-MADGVAIGFAdaSIRHDyvngcdSSPVVFLEGIFVLPSFRQRGVAKQ 95
Cdd:COG0454    7 TPEDINFILLIEALDAelkamegsLAGAEFIAvDDKGEPIGFA--GLRRL------DDKVLELKRLYVLPEYRGKGIGKA 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 301158147  96 LIAAVQRWGTNKGCREMASDTSPENTISQKVHQALGFEETERVIFYR 142
Cdd:COG0454   79 LLEALLEWARERGCTALELDTLDGNPAAIRFYERLGFKEIERYVAYV 125
RimI COG0456
Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal ...
 56-141 5.90e-13

Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440224 [Multi-domain]  Cd Length: 92  Bit Score: 60.44  E-value: 5.90e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301158147  56 GFADASIRHDyvngcdsSPVVFLEGIFVLPSFRQRGVAKQLIAAVQRWGTNKGCREMASDTSPENTISQKVHQALGFEET 135
Cdd:COG0456    1 GFALLGLVDG-------GDEAEIEDLAVDPEYRGRGIGRALLEAALERARERGARRLRLEVREDNEAAIALYEKLGFEEV 73


                 ....*.
gi 301158147 136 ERVIFY 141
Cdd:COG0456   74 GERPNY 79
yhbS COG3153
Predicted N-acetyltransferase YhbS [General function prediction only];
3-137 1.03e-12

Predicted N-acetyltransferase YhbS [General function prediction only];


Pssm-ID: 442387 [Multi-domain]  Cd Length: 142  Bit Score: 61.25  E-value: 1.03e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301158147   3 IRQMNRTHLDHWRGLRKQLWPGHPDDAHLADGEEILQADHlaSFIAMADGVAIGFADASIRHDYvngcDSSPVVFLEGIF 82
Cdd:COG3153    1 IRPATPEDAEAIAALLRAAFGPGREAELVDRLREDPAAGL--SLVAEDDGEIVGHVALSPVDID----GEGPALLLGPLA 74

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 301158147  83 VLPSFRQRGVAKQLIAAVQRWGTNKGCREMASDTSPENtisQKVHQALGFEETER 137
Cdd:COG3153   75 VDPEYRGQGIGRALMRAALEAARERGARAVVLLGDPSL---LPFYERFGFRPAGE 126
COG3393 COG3393
Predicted acetyltransferase, GNAT family [General function prediction only];
71-144 3.48e-11

Predicted acetyltransferase, GNAT family [General function prediction only];


Pssm-ID: 442620 [Multi-domain]  Cd Length: 86  Bit Score: 55.69  E-value: 3.48e-11
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 301158147  71 DSSPVVFLEGIFVLPSFRQRGVAKQLIAAVQRWGTNKGCREMASDTSPENTISQKVHQALGFEETERVIFYRKR 144
Cdd:COG3393   11 ESPGVAEISGVYTHPEYRGRGLASALVAALAREALARGARTPFLYVDADNPAARRLYERLGFRPVGEYATVLFR 84
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 45-112 9.13e-09

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 48.81  E-value: 9.13e-09
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 301158147  45 SFIAMADGVAIGFADASIRHDyvngcdSSPVVFLEGIFVLPSFRQRGVAKQLIAAVQRWGTNKGCREM 112
Cdd:cd04301    1 FLVAEDDGEIVGFASLSPDGS------GGDTAYIGDLAVLPEYRGKGIGSALLEAAEEEARERGAKRL 62
Acetyltransf_7 pfam13508
Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.
 46-134 1.08e-08

Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.


Pssm-ID: 463905 [Multi-domain]  Cd Length: 84  Bit Score: 49.38  E-value: 1.08e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301158147   46 FIAMADGVAIGFADASIRHDYVngcdsspVVFLEGIFVLPSFRQRGVAKQLIAAVQRWGTNKGCREMASDTSPENtisQK 125
Cdd:pfam13508   6 FVAEDDGKIVGFAALLPLDDEG-------ALAELRLAVHPEYRGQGIGRALLEAAEAAAKEGGIKLLELETTNRA---AA 75


                  ....*....
gi 301158147  126 VHQALGFEE 134
Cdd:pfam13508  76 FYEKLGFEE 84
ArgA COG1246
N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and ...
 35-137 1.70e-08

N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and metabolism]; N-acetylglutamate synthase or related acetyltransferase, GNAT family is part of the Pathway/BioSystem: Arginine biosynthesis


Pssm-ID: 440859 [Multi-domain]  Cd Length: 132  Bit Score: 49.99  E-value: 1.70e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301158147  35 EEILQADHLASFIAMADGVAIGFADASIRHDyvngcdssPVVFLEGIFVLPSFRQRGVAKQLIAAVQRWGTNKGCREMAS 114
Cdd:COG1246   20 PYALEEEIGEFWVAEEDGEIVGCAALHPLDE--------DLAELRSLAVHPDYRGRGIGRRLLEALLAEARELGLKRLFL 91

                         90       100
                 ....*....|....*....|...
gi 301158147 115 DTSPEntiSQKVHQALGFEETER 137
Cdd:COG1246   92 LTTSA---AIHFYEKLGFEEIDK 111
RimL COG1670
Protein N-acetyltransferase, RimJ/RimL family [Translation, ribosomal structure and biogenesis, ...
 3-135 6.42e-08

Protein N-acetyltransferase, RimJ/RimL family [Translation, ribosomal structure and biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 441276 [Multi-domain]  Cd Length: 173  Bit Score: 48.84  E-value: 6.42e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301158147   3 IRQMNRTHLDHWRGLRK-----QLWPGHPDD-----AHLADGEEILQADHLASFIA--MADGVAIGFADASiRHDYVNGC 70
Cdd:COG1670   10 LRPLRPEDAEALAELLNdpevaRYLPGPPYSleearAWLERLLADWADGGALPFAIedKEDGELIGVVGLY-DIDRANRS 88

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 301158147  71 dsspvVFLeGIFVLPSFRQRGVAKQLIAAVQRWG-TNKGCREMASDTSPENTISQKVHQALGFEET 135
Cdd:COG1670   89 -----AEI-GYWLAPAYWGKGYATEALRALLDYAfEELGLHRVEAEVDPDNTASIRVLEKLGFRLE 148
PRK03624 PRK03624
putative acetyltransferase; Provisional
 83-140 8.03e-07

putative acetyltransferase; Provisional


Pssm-ID: 235142 [Multi-domain]  Cd Length: 140  Bit Score: 45.30  E-value: 8.03e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 301158147  83 VLPSFRQRGVAKQLIAAVQRWGTNKGCREMASDTSPENTISQKVHQALGFEETERVIF 140
Cdd:PRK03624  76 VHPDFRGRGIGRALVARLEKKLIARGCPKINLQVREDNDAVLGFYEALGYEEQDRISL 133
Acetyltransf_3 pfam13302
Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.
 3-133 2.15e-04

Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.


Pssm-ID: 379112 [Multi-domain]  Cd Length: 139  Bit Score: 38.87  E-value: 2.15e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301158147    3 IRQMNRTHLDH---WRGLRKQLWPGHPDDAHLADGEEILqADHLASF---------IAMADGVAIGFADASIRHDYVNGC 70
Cdd:pfam13302   4 LRPLTEEDAEAlfeLLSDPEVMRYGVPWPLTLEEAREWL-ARIWAADeaergygwaIELKDTGFIGSIGLYDIDGEPERA 82

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 301158147   71 DSspvvfleGIFVLPSFRQRGVAKQ-LIAAVQRWGTNKGCREMASDTSPENTISQKVHQALGFE 133
Cdd:pfam13302  83 EL-------GYWLGPDYWGKGYATEaVRALLEYAFEELGLPRLVARIDPENTASRRVLEKLGFK 139
FR47 pfam08445
FR47-like protein; The members of this family are similar to the C-terminal region of the D. ...
 67-138 6.56e-04

FR47-like protein; The members of this family are similar to the C-terminal region of the D. melanogaster hypothetical protein FR47. This protein has been found to consist of two N-acyltransferase-like domains swapped with the C-terminal strands.


Pssm-ID: 117022 [Multi-domain]  Cd Length: 86  Bit Score: 36.54  E-value: 6.56e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 301158147   67 VNGCDSSPVVFLEGIFVLPSFRQRGVAKQLIAAVQRWGTNKGCREMASdTSPENTISQKVHQALGFE---ETERV 138
Cdd:pfam08445  13 AAWCLRLPGGELGALQTLPEHRRRGLGSRLVAALARGIAERGITPFAV-VVAGNTPSRRLYEKLGFRkidETYWV 86
ElaA COG2153
Predicted N-acyltransferase, GNAT family [General function prediction only];
33-112 1.17e-03

Predicted N-acyltransferase, GNAT family [General function prediction only];


Pssm-ID: 441756 [Multi-domain]  Cd Length: 134  Bit Score: 36.70  E-value: 1.17e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301158147  33 DGEEiLQADHlasFIAMADGVAIGFAdaSIRHDyvngcdSSPVVFLEGIFVLPSFRQRGVAKQLIAAVQRWGTNKGCREM 112
Cdd:COG2153   28 DGKD-EDARH---LLAYDDGELVATA--RLLPP------GDGEAKIGRVAVLPEYRGQGLGRALMEAAIEEARERGARRI 95
Acetyltransf_10 pfam13673
Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase ...
 35-138 8.96e-03

Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 463953 [Multi-domain]  Cd Length: 128  Bit Score: 34.17  E-value: 8.96e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301158147   35 EEILQADHLaSFIAMADGVAIGFAdaSIRhdyvngcDSSpvvFLEGIFVLPSFRQRGVAKQLIAAVQRWGTNKG--CREM 112
Cdd:pfam13673  24 ERIDQGEYF-FFVAFEGGQIVGVI--ALR-------DRG---HISLLFVDPDYQGQGIGKALLEAVEDYAEKDGikLSEL 90

                          90       100
                  ....*....|....*....|....*.
gi 301158147  113 ASDTSPEntiSQKVHQALGFEETERV 138
Cdd:pfam13673  91 TVNASPY---AVPFYEKLGFRATGPE 113
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH