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Conserved domains on  [gi|351065341|emb|CCD61318|]
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GPN-loop GTPase 2 [Caenorhabditis elegans]

Protein Classification

GPN-loop GTPase family protein( domain architecture ID 13027372)

GPN-loop GTPase family protein is characterized by a highly conserved motif consisting of the amino acids Gly-Pro-Asn such as Homo sapiens GPN-loop GTPase 2, a small GTPase which is required for proper nuclear import of RNA polymerase II (RNAPII), and may act at an RNAP assembly step prior to nuclear import

CATH:  3.40.50.300
EC:  3.6.5.-
Gene Ontology:  GO:0005525|GO:0003924
PubMed:  11916378

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GPN2 cd17871
GPN-loop GTPase 2; GPN-loop GTPase 2 (GPN2) is a small GTPase required for proper localization ...
 2-246 5.02e-103

GPN-loop GTPase 2; GPN-loop GTPase 2 (GPN2) is a small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). It forms heterodimers with GPN1 or GPN3.


:

Pssm-ID: 349780  Cd Length: 196  Bit Score: 297.91  E-value: 5.02e-103
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065341   2 YGVLVIGAPGAGKSTFCAGLTDIFSQTKRPFLTINLDPANDTMAYAPDVNITEMITVNDVMDRLGLGPNGALKYCIETLG 81
Cdd:cd17871    1 FGQVVIGPPGSGKTTYCKGMQQFLSALGRKVAVVNLDPANEFLPYPCDVDIRELITVEDVMEELKLGPNGGLLYCMEYLE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065341  82 ANCNWLLQKIEANHKKYLIIDCPGQLELYKSEGELWKVIRFLEKSGVRLCALHLADSLYCSDPSKFISVALSTLATMVTM 161
Cdd:cd17871   81 KNIDWLIDKLKKLKDSYLIFDCPGQVELYTHHNSLRNILDKLQKWLYRLVAVHLVDSHYCSDPSKFISALLLSLSTMLRL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065341 162 EMPQVNCLSKadlfsedgtydleffshlpdvnrlldllnevpglekyrklneaicgvisdFDLVSFVPLAVENKESMMKV 241
Cdd:cd17871  161 ELPHVNVLSK--------------------------------------------------IDLVSFIPLDVQDKESMLRL 190


                 ....*
gi 351065341 242 IQMVD 246
Cdd:cd17871  191 LKAID 195
 
Name Accession Description Interval E-value
GPN2 cd17871
GPN-loop GTPase 2; GPN-loop GTPase 2 (GPN2) is a small GTPase required for proper localization ...
 2-246 5.02e-103

GPN-loop GTPase 2; GPN-loop GTPase 2 (GPN2) is a small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). It forms heterodimers with GPN1 or GPN3.


Pssm-ID: 349780  Cd Length: 196  Bit Score: 297.91  E-value: 5.02e-103
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065341   2 YGVLVIGAPGAGKSTFCAGLTDIFSQTKRPFLTINLDPANDTMAYAPDVNITEMITVNDVMDRLGLGPNGALKYCIETLG 81
Cdd:cd17871    1 FGQVVIGPPGSGKTTYCKGMQQFLSALGRKVAVVNLDPANEFLPYPCDVDIRELITVEDVMEELKLGPNGGLLYCMEYLE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065341  82 ANCNWLLQKIEANHKKYLIIDCPGQLELYKSEGELWKVIRFLEKSGVRLCALHLADSLYCSDPSKFISVALSTLATMVTM 161
Cdd:cd17871   81 KNIDWLIDKLKKLKDSYLIFDCPGQVELYTHHNSLRNILDKLQKWLYRLVAVHLVDSHYCSDPSKFISALLLSLSTMLRL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065341 162 EMPQVNCLSKadlfsedgtydleffshlpdvnrlldllnevpglekyrklneaicgvisdFDLVSFVPLAVENKESMMKV 241
Cdd:cd17871  161 ELPHVNVLSK--------------------------------------------------IDLVSFIPLDVQDKESMLRL 190


                 ....*
gi 351065341 242 IQMVD 246
Cdd:cd17871  191 LKAID 195
ATP_bind_1 pfam03029
Conserved hypothetical ATP binding protein; Members of this family are found in a range of ...
 6-251 1.36e-94

Conserved hypothetical ATP binding protein; Members of this family are found in a range of archaea and eukaryotes and have hypothesized ATP binding activity.


Pssm-ID: 397252 [Multi-domain]  Cd Length: 238  Bit Score: 278.10  E-value: 1.36e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065341    6 VIGAPGAGKSTFCAGLTDIFSQTKRPFLTINLDPANDTMAYAPDVNITEMITVNDVMDRLGLGPNGALKYCIETLGANCN 85
Cdd:pfam03029   1 VVGPAGSGKTTFVGALSEILPLRGRPVYVVNLDPAAENLPYPADIDIRELITVADVMEDYGLGPNGALTVAMDFGRITLD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065341   86 WLLQKIEaNHKKYLIIDCPGQLELYKSEGELWKVIRFLEKSGvRLCALHLADSLYCSDPSKFISVALSTLATMVTMEMPQ 165
Cdd:pfam03029  81 WLDEELK-REDDYYLFDTPGQIELFTHWDSLAIIVEALESRG-ALGAVYLVDTRRLTDPTDFFSGLLYALSIMLRLGLPF 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065341  166 VNCLSKADLFSEdgTYDLEFFSHLPDVNRLLDLLNevpglEKYRKLNEAICGVISDFDLV-SFVPLAVENKESMMKVIQM 244
Cdd:pfam03029 159 VVALNKFDLLSL--EFALKWFTDPEDLQLLLELDD-----GKYRKLNEAIREALDLFYLVpVFLPDARERGESMEDLLTL 231


                  ....*..
gi 351065341  245 VDAANGF 251
Cdd:pfam03029 232 IDEALQY 238
PRK13768 PRK13768
GTPase; Provisional
 1-245 1.16e-42

GTPase; Provisional


Pssm-ID: 237498 [Multi-domain]  Cd Length: 253  Bit Score: 145.78  E-value: 1.16e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065341   1 MYGVLVIGAPGAGKSTFCAGLTDIFSQTKRPFLTINLDPANDTMAYAPDVNITEMITVNDVMDRLGLGPNGALKYCIETL 80
Cdd:PRK13768   2 MYIVFFLGTAGSGKTTLTKALSDWLEEQGYDVAIVNLDPAVEYLPYTPDFDVRDYVTAREIMKKYGLGPNGALIASVDLL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065341  81 GANCNWLLQKIEANHKKYLIIDCPGQLEL--YKSEGelWKVIRFLEKSGvRLCALHLADSLYCSDPSKFISVALSTLATM 158
Cdd:PRK13768  82 LTKADEIKEEIESLDADYVLVDTPGQMELfaFRESG--RKLVERLSGSS-KSVVVFLIDAVLAKTPSDFVSLLLLALSVQ 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065341 159 VTMEMPQVNCLSKADLFSEDGTYDLEFFSHlpDVNRLLDLLNEVPGLEKYrkLNEAICGVISDFDLVS-FVPLAVENKES 237
Cdd:PRK13768 159 LRLGLPQIPVLNKADLLSEEELERILKWLE--DPEYLLEELKLEKGLQGL--LSLELLRALEETGLPVrVIPVSAKTGEG 234

                        250
                 ....*....|.
gi 351065341 238 MMKV---IQMV 245
Cdd:PRK13768 235 FDELyaaIQEV 245
Gem1 COG1100
GTPase SAR1 family domain [General function prediction only];
4-217 1.08e-05

GTPase SAR1 family domain [General function prediction only];


Pssm-ID: 440717 [Multi-domain]  Cd Length: 177  Bit Score: 44.97  E-value: 1.08e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065341   4 VLVIGAPGAGKSTFCAGLT-DIFSQTKRpfltinldpandtmayapdvnitemitvndvmdrlgLGPNGALKYcietlga 82
Cdd:COG1100    6 IVVVGTGGVGKTSLVNRLVgDIFSLEKY------------------------------------LSTNGVTID------- 42

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065341  83 ncNWLLqKIEANHKKYLIIDCPGQLElYKSEGELWkVIRFLEKSGvrlcALHLADSlycSDPSKFISVA-LSTLATMVTM 161
Cdd:COG1100   43 --KKEL-KLDGLDVDLVIWDTPGQDE-FRETRQFY-ARQLTGASL----YLFVVDG---TREETLQSLYeLLESLRRLGK 110

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065341 162 EMPQVNCLSKADLFSEDGtydleffshLPDVNRLLDLLNEV-------------PGLEK-YRKLNEAICG 217
Cdd:COG1100  111 KSPIILVLNKIDLYDEEE---------IEDEERLKEALSEDnivevvatsaktgEGVEElFAALAEILRG 171
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 4-125 2.06e-03

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 37.74  E-value: 2.06e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065341     4 VLVIGAPGAGKSTFCAGLTDIFSQTKRPFLTINLDpanDTMAYAPDVNITEMITVNDVMDRLGLGPNGAlkycietlgan 83
Cdd:smart00382   5 ILIVGPPGSGKTTLARALARELGPPGGGVIYIDGE---DILEEVLDQLLLIIVGGKKASGSGELRLRLA----------- 70

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|..
gi 351065341    84 cnwlLQKIEANHKKYLIIDCPGQLELYKSEGELWKVIRFLEK 125
Cdd:smart00382  71 ----LALARKLKPDVLILDEITSLLDAEQEALLLLLEELRLL 108
 
Name Accession Description Interval E-value
GPN2 cd17871
GPN-loop GTPase 2; GPN-loop GTPase 2 (GPN2) is a small GTPase required for proper localization ...
 2-246 5.02e-103

GPN-loop GTPase 2; GPN-loop GTPase 2 (GPN2) is a small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). It forms heterodimers with GPN1 or GPN3.


Pssm-ID: 349780  Cd Length: 196  Bit Score: 297.91  E-value: 5.02e-103
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065341   2 YGVLVIGAPGAGKSTFCAGLTDIFSQTKRPFLTINLDPANDTMAYAPDVNITEMITVNDVMDRLGLGPNGALKYCIETLG 81
Cdd:cd17871    1 FGQVVIGPPGSGKTTYCKGMQQFLSALGRKVAVVNLDPANEFLPYPCDVDIRELITVEDVMEELKLGPNGGLLYCMEYLE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065341  82 ANCNWLLQKIEANHKKYLIIDCPGQLELYKSEGELWKVIRFLEKSGVRLCALHLADSLYCSDPSKFISVALSTLATMVTM 161
Cdd:cd17871   81 KNIDWLIDKLKKLKDSYLIFDCPGQVELYTHHNSLRNILDKLQKWLYRLVAVHLVDSHYCSDPSKFISALLLSLSTMLRL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065341 162 EMPQVNCLSKadlfsedgtydleffshlpdvnrlldllnevpglekyrklneaicgvisdFDLVSFVPLAVENKESMMKV 241
Cdd:cd17871  161 ELPHVNVLSK--------------------------------------------------IDLVSFIPLDVQDKESMLRL 190


                 ....*
gi 351065341 242 IQMVD 246
Cdd:cd17871  191 LKAID 195
ATP_bind_1 pfam03029
Conserved hypothetical ATP binding protein; Members of this family are found in a range of ...
 6-251 1.36e-94

Conserved hypothetical ATP binding protein; Members of this family are found in a range of archaea and eukaryotes and have hypothesized ATP binding activity.


Pssm-ID: 397252 [Multi-domain]  Cd Length: 238  Bit Score: 278.10  E-value: 1.36e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065341    6 VIGAPGAGKSTFCAGLTDIFSQTKRPFLTINLDPANDTMAYAPDVNITEMITVNDVMDRLGLGPNGALKYCIETLGANCN 85
Cdd:pfam03029   1 VVGPAGSGKTTFVGALSEILPLRGRPVYVVNLDPAAENLPYPADIDIRELITVADVMEDYGLGPNGALTVAMDFGRITLD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065341   86 WLLQKIEaNHKKYLIIDCPGQLELYKSEGELWKVIRFLEKSGvRLCALHLADSLYCSDPSKFISVALSTLATMVTMEMPQ 165
Cdd:pfam03029  81 WLDEELK-REDDYYLFDTPGQIELFTHWDSLAIIVEALESRG-ALGAVYLVDTRRLTDPTDFFSGLLYALSIMLRLGLPF 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065341  166 VNCLSKADLFSEdgTYDLEFFSHLPDVNRLLDLLNevpglEKYRKLNEAICGVISDFDLV-SFVPLAVENKESMMKVIQM 244
Cdd:pfam03029 159 VVALNKFDLLSL--EFALKWFTDPEDLQLLLELDD-----GKYRKLNEAIREALDLFYLVpVFLPDARERGESMEDLLTL 231


                  ....*..
gi 351065341  245 VDAANGF 251
Cdd:pfam03029 232 IDEALQY 238
GPN3 cd17872
GPN-loop GTPase 3; GPN-loop GTPase 3 (GPN3) is a small GTPase that is required for nuclear ...
 2-176 2.55e-62

GPN-loop GTPase 3; GPN-loop GTPase 3 (GPN3) is a small GTPase that is required for nuclear targeting of RNA polymerase II. It forms heterodimers with GPN1.


Pssm-ID: 349781 [Multi-domain]  Cd Length: 196  Bit Score: 194.28  E-value: 2.55e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065341   2 YGVLVIGAPGAGKSTFCAGLTDIFSQTKRPFLTINLDPANDTMAYAPDVNITEMITVNDVMDRLGLGPNGALKYCIETLG 81
Cdd:cd17872    1 YAQLVMGPAGSGKSTYCSTLQEHCETLGRSVHVVNLDPAAEEFEYPVSIDIRDLISLEDVMEELGLGPNGGLVYCMEYLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065341  82 ANCNWLLQKIEANHKKYLIIDCPGQLELYKSEGELWKVIRFLEKSGVRLCALHLADSLYCSDPSKFISVALSTLATMVTM 161
Cdd:cd17872   81 ENLDWLEEQLGDYEDDYLIFDCPGQIELYTHLPVMKRLVDALQRWGFRLCAVYLLDSQFISDASKFISGVLSALSAMIQL 160

                        170
                 ....*....|....*
gi 351065341 162 EMPQVNCLSKADLFS 176
Cdd:cd17872  161 ELPHVNVLTKMDLVS 175
GPN cd17868
GPN-loop GTPase; GPN-loop GTPases are deeply evolutionarily conserved family of three small ...
 2-176 1.49e-57

GPN-loop GTPase; GPN-loop GTPases are deeply evolutionarily conserved family of three small GTPases, Gpn1, 2, and 3. They form heterodimers, interact with RNA polymerase II and may function in nuclear import of RNA polymerase II.


Pssm-ID: 349777 [Multi-domain]  Cd Length: 198  Bit Score: 182.52  E-value: 1.49e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065341   2 YGVLVIGAPGAGKSTFCAGLTDIFSQTKRPFLTINLDPANDTMAYAPDVNITEMITVNDVMDRLGLGPNGALKYCIETLG 81
Cdd:cd17868    1 YAILVIGPAGSGKTTFCKNMKEHLRARKRNPYVINLDPGNINEPLDYDIDIRDLIKYDDIMEELDLGPNGSIVYSLEYFE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065341  82 ANCNWLLQKIEANHKK--YLIIDCPGQLELYKSEGELWKVIRFLEKSGVRLCALHLADSLYCSDPSKFISVALSTLATMV 159
Cdd:cd17868   81 KNFDWFEKKLENEDKNphYILFDCPGQIELFTHSDSLPKIIERFASWFISVVIVNLIDSQFLSDKSKFLSNLLIALSSMF 160

                        170
                 ....*....|....*..
gi 351065341 160 TMEMPQVNCLSKADLFS 176
Cdd:cd17868  161 RLELPQINVISKMDLLD 177
PRK13768 PRK13768
GTPase; Provisional
 1-245 1.16e-42

GTPase; Provisional


Pssm-ID: 237498 [Multi-domain]  Cd Length: 253  Bit Score: 145.78  E-value: 1.16e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065341   1 MYGVLVIGAPGAGKSTFCAGLTDIFSQTKRPFLTINLDPANDTMAYAPDVNITEMITVNDVMDRLGLGPNGALKYCIETL 80
Cdd:PRK13768   2 MYIVFFLGTAGSGKTTLTKALSDWLEEQGYDVAIVNLDPAVEYLPYTPDFDVRDYVTAREIMKKYGLGPNGALIASVDLL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065341  81 GANCNWLLQKIEANHKKYLIIDCPGQLEL--YKSEGelWKVIRFLEKSGvRLCALHLADSLYCSDPSKFISVALSTLATM 158
Cdd:PRK13768  82 LTKADEIKEEIESLDADYVLVDTPGQMELfaFRESG--RKLVERLSGSS-KSVVVFLIDAVLAKTPSDFVSLLLLALSVQ 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065341 159 VTMEMPQVNCLSKADLFSEDGTYDLEFFSHlpDVNRLLDLLNEVPGLEKYrkLNEAICGVISDFDLVS-FVPLAVENKES 237
Cdd:PRK13768 159 LRLGLPQIPVLNKADLLSEEELERILKWLE--DPEYLLEELKLEKGLQGL--LSLELLRALEETGLPVrVIPVSAKTGEG 234

                        250
                 ....*....|.
gi 351065341 238 MMKV---IQMV 245
Cdd:PRK13768 235 FDELyaaIQEV 245
GPN1 cd17870
GPN-loop GTPase 1; GPN-loop GTPase 1 (GPN1, also kown as MBD2-interacting protein or MBDin, ...
 4-223 6.92e-26

GPN-loop GTPase 1; GPN-loop GTPase 1 (GPN1, also kown as MBD2-interacting protein or MBDin, RNAPII-associated protein 4, and XPA-binding protein 1) is a GTPase is required for nuclear targeting of RNA polymerase II. It forms heterodimers with GPN3.


Pssm-ID: 349779 [Multi-domain]  Cd Length: 241  Bit Score: 101.88  E-value: 6.92e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065341   4 VLVIGAPGAGKSTFCAGLTDIFSQTKRPFLTINLDPANDTMAYAPDVNITEMITVNDVMDRLGLGPNGALKYCIETLGAN 83
Cdd:cd17870    3 IIVVGMAGSGKTTFVQRLNAYLHDNKKPPYVINLDPAVKSLPYPPNIDIRDTVNYKEVMKQYGLGPNGAIVTSLNLFATK 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065341  84 CNWLLQKIEANHKK--YLIIDCPGQLELY--KSEGELwkVIRFLeKSGVRLCALHLADSLYCSDPSKFISVALSTLATMV 159
Cdd:cd17870   83 FDQVINLIEKRASEldYVIIDTPGQIEVFtwSASGSI--ITEAL-ASSFPTVVVYVVDTPRCTSPITFMSNMLYACSILY 159

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 351065341 160 TMEMPQVNCLSKADLFSEDgtYDLEFFShlpDVNRLLDLLNEVPGLekYRKLNEAICGVISDFD 223
Cdd:cd17870  160 KTKLPFILVFNKTDVVSHD--FAIEWME---DFESFQDALKEDSSY--MSSLSRSMSLVLDEFY 216
Gem1 COG1100
GTPase SAR1 family domain [General function prediction only];
4-217 1.08e-05

GTPase SAR1 family domain [General function prediction only];


Pssm-ID: 440717 [Multi-domain]  Cd Length: 177  Bit Score: 44.97  E-value: 1.08e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065341   4 VLVIGAPGAGKSTFCAGLT-DIFSQTKRpfltinldpandtmayapdvnitemitvndvmdrlgLGPNGALKYcietlga 82
Cdd:COG1100    6 IVVVGTGGVGKTSLVNRLVgDIFSLEKY------------------------------------LSTNGVTID------- 42

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065341  83 ncNWLLqKIEANHKKYLIIDCPGQLElYKSEGELWkVIRFLEKSGvrlcALHLADSlycSDPSKFISVA-LSTLATMVTM 161
Cdd:COG1100   43 --KKEL-KLDGLDVDLVIWDTPGQDE-FRETRQFY-ARQLTGASL----YLFVVDG---TREETLQSLYeLLESLRRLGK 110

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065341 162 EMPQVNCLSKADLFSEDGtydleffshLPDVNRLLDLLNEV-------------PGLEK-YRKLNEAICG 217
Cdd:COG1100  111 KSPIILVLNKIDLYDEEE---------IEDEERLKEALSEDnivevvatsaktgEGVEElFAALAEILRG 171
PRK13764 PRK13764
ATPase; Provisional
 3-21 1.06e-03

ATPase; Provisional


Pssm-ID: 184311 [Multi-domain]  Cd Length: 602  Bit Score: 40.21  E-value: 1.06e-03
                         10
                 ....*....|....*....
gi 351065341   3 GVLVIGAPGAGKSTFCAGL 21
Cdd:PRK13764 259 GILIAGAPGAGKSTFAQAL 277
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 4-125 2.06e-03

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 37.74  E-value: 2.06e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065341     4 VLVIGAPGAGKSTFCAGLTDIFSQTKRPFLTINLDpanDTMAYAPDVNITEMITVNDVMDRLGLGPNGAlkycietlgan 83
Cdd:smart00382   5 ILIVGPPGSGKTTLARALARELGPPGGGVIYIDGE---DILEEVLDQLLLIIVGGKKASGSGELRLRLA----------- 70

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|..
gi 351065341    84 cnwlLQKIEANHKKYLIIDCPGQLELYKSEGELWKVIRFLEK 125
Cdd:smart00382  71 ----LALARKLKPDVLILDEITSLLDAEQEALLLLLEELRLL 108
CooC1 cd02034
accessory protein CooC1; The accessory protein CooC1, a nickel-binding ATPase, participates in ...
 6-102 2.59e-03

accessory protein CooC1; The accessory protein CooC1, a nickel-binding ATPase, participates in the incorporation of nickel into the complex active site ([Ni-4Fe-4S]) cluster of Ni,Fe-dependent carbon monoxide dehydrogenase (CODH). CODH from Rhodospirillum rubrum catalyzes the reversible oxidation of CO to CO2. CODH contains a nickel-iron-sulfur cluster (C-center) and an iron-sulfur cluster (B-center). CO oxidation occurs at the C-center. Three accessory proteins encoded by cooCTJ genes are involved in nickel incorporation into a nickel site. CooC functions as a nickel insertase that mobilizes nickel to apoCODH using energy released from ATP hydrolysis. CooC is a homodimer and has NTPase activities. Mutation at the P-loop abolishs its function.


Pssm-ID: 349754 [Multi-domain]  Cd Length: 249  Bit Score: 38.45  E-value: 2.59e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065341   6 VIGAPGAGKSTFCAGLTDIFSQTKRPFLTINLDPaNDTMAYAPDVNITEM---ITVNDVMDRLGLGP------------- 69
Cdd:cd02034    5 VAGKGGVGKTTIAALLIRYLAKKGGKVLAVDADP-NSNLAETLGVEVEKLpliKTIGDIRERTGAKKgeppegmslnpyv 83

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 351065341  70 NGALKYC--------------IETLGANC-----NWL---LQKIEANHKKYLIID 102
Cdd:cd02034   84 DDIIKEIivepdgidllvmgrPEGGGSGCycpvnALLrelLRHLALKNYEYVVID 138
AAA_24 pfam13479
AAA domain; This AAA domain is found in a wide variety of presumed phage proteins.
 4-63 5.74e-03

AAA domain; This AAA domain is found in a wide variety of presumed phage proteins.


Pssm-ID: 433243  Cd Length: 199  Bit Score: 36.92  E-value: 5.74e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065341    4 VLVIGAPGAGKSTFCAgltdifsQTKRPFLtINLDPANDTMAYAPDVNITEMITVNDVMD 63
Cdd:pfam13479   5 ILIYGPSGIGKTTFAK-------TLPKPLF-LDTEKGSKALDGDRFPDIVIRDSWQDFLD 56
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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