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Conserved domains on  [gi|351065467|emb|CCD61440|]
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N-acetyltransferase domain-containing protein [Caenorhabditis elegans]

Protein Classification

GNAT family N-acetyltransferase( domain architecture ID 10136841)

GNAT family N-acetyltransferase catalyzes the transfer of an acetyl group from acetyl-CoA to a substrate

CATH:  3.40.630.30
EC:  2.3.1.-
Gene Ontology:  GO:0008080
PubMed:  10940244|9175471|15581578
SCOP:  3000403

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 61-104 9.75e-05

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


:

Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 39.95  E-value: 9.75e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 351065467  61 MVGSVVWNEYDDICWLGFYLLAPEYRGKGIGSMIWAQAMSRIRK 104
Cdd:cd04301   13 FASLSPDGSGGDTAYIGDLAVLPEYRGKGIGSALLEAAEEEARE 56
RimL super family cl34333
Protein N-acetyltransferase, RimJ/RimL family [Translation, ribosomal structure and biogenesis, ...
 4-92 7.20e-03

Protein N-acetyltransferase, RimJ/RimL family [Translation, ribosomal structure and biogenesis, Posttranslational modification, protein turnover, chaperones];


The actual alignment was detected with superfamily member COG1670:

Pssm-ID: 441276 [Multi-domain]  Cd Length: 173  Bit Score: 36.90  E-value: 7.20e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065467   4 LFEIIDNPDSSSPLWKQWKNLVDTEGWtsddnsVTEMVPSLPTTRSV-FAVTKTPERSMVGSVVWNEYDDI---CWLGfY 79
Cdd:COG1670   21 LAELLNDPEVARYLPGPPYSLEEARAW------LERLLADWADGGALpFAIEDKEDGELIGVVGLYDIDRAnrsAEIG-Y 93

                         90
                 ....*....|...
gi 351065467  80 LLAPEYRGKGIGS 92
Cdd:COG1670   94 WLAPAYWGKGYAT 106
 
Name Accession Description Interval E-value
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 61-104 9.75e-05

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 39.95  E-value: 9.75e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 351065467  61 MVGSVVWNEYDDICWLGFYLLAPEYRGKGIGSMIWAQAMSRIRK 104
Cdd:cd04301   13 FASLSPDGSGGDTAYIGDLAVLPEYRGKGIGSALLEAAEEEARE 56
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 61-104 5.11e-04

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 39.04  E-value: 5.11e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 351065467   61 MVGSVVWNEYDDICWLGFYLLAPEYRGKGIGSMIWAQAMSRIRK 104
Cdd:pfam00583  47 FASLSIIDDEPPVGEIEGLAVAPEYRGKGIGTALLQALLEWARE 90
yhbS COG3153
Predicted N-acetyltransferase YhbS [General function prediction only];
62-114 2.94e-03

Predicted N-acetyltransferase YhbS [General function prediction only];


Pssm-ID: 442387 [Multi-domain]  Cd Length: 142  Bit Score: 37.37  E-value: 2.94e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 351065467  62 VGSV---VWNEYDDICWLGFYLLA--PEYRGKGIGSMIWAQAMSRIRKdlvLGLRGVV 114
Cdd:COG3153   51 VGHValsPVDIDGEGPALLLGPLAvdPEYRGQGIGRALMRAALEAARE---RGARAVV 105
RimL COG1670
Protein N-acetyltransferase, RimJ/RimL family [Translation, ribosomal structure and biogenesis, ...
 4-92 7.20e-03

Protein N-acetyltransferase, RimJ/RimL family [Translation, ribosomal structure and biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 441276 [Multi-domain]  Cd Length: 173  Bit Score: 36.90  E-value: 7.20e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065467   4 LFEIIDNPDSSSPLWKQWKNLVDTEGWtsddnsVTEMVPSLPTTRSV-FAVTKTPERSMVGSVVWNEYDDI---CWLGfY 79
Cdd:COG1670   21 LAELLNDPEVARYLPGPPYSLEEARAW------LERLLADWADGGALpFAIEDKEDGELIGVVGLYDIDRAnrsAEIG-Y 93

                         90
                 ....*....|...
gi 351065467  80 LLAPEYRGKGIGS 92
Cdd:COG1670   94 WLAPAYWGKGYAT 106
 
Name Accession Description Interval E-value
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 61-104 9.75e-05

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 39.95  E-value: 9.75e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 351065467  61 MVGSVVWNEYDDICWLGFYLLAPEYRGKGIGSMIWAQAMSRIRK 104
Cdd:cd04301   13 FASLSPDGSGGDTAYIGDLAVLPEYRGKGIGSALLEAAEEEARE 56
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 61-104 5.11e-04

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 39.04  E-value: 5.11e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 351065467   61 MVGSVVWNEYDDICWLGFYLLAPEYRGKGIGSMIWAQAMSRIRK 104
Cdd:pfam00583  47 FASLSIIDDEPPVGEIEGLAVAPEYRGKGIGTALLQALLEWARE 90
Acetyltransf_7 pfam13508
Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.
 62-111 1.98e-03

Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.


Pssm-ID: 463905 [Multi-domain]  Cd Length: 84  Bit Score: 36.66  E-value: 1.98e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 351065467   62 VGSVVWNEYDDICWLGFYLLA--PEYRGKGIGSMIWAQAMSRIRKDLVLGLR 111
Cdd:pfam13508  15 VGFAALLPLDDEGALAELRLAvhPEYRGQGIGRALLEAAEAAAKEGGIKLLE 66
yhbS COG3153
Predicted N-acetyltransferase YhbS [General function prediction only];
62-114 2.94e-03

Predicted N-acetyltransferase YhbS [General function prediction only];


Pssm-ID: 442387 [Multi-domain]  Cd Length: 142  Bit Score: 37.37  E-value: 2.94e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 351065467  62 VGSV---VWNEYDDICWLGFYLLA--PEYRGKGIGSMIWAQAMSRIRKdlvLGLRGVV 114
Cdd:COG3153   51 VGHValsPVDIDGEGPALLLGPLAvdPEYRGQGIGRALMRAALEAARE---RGARAVV 105
RimL COG1670
Protein N-acetyltransferase, RimJ/RimL family [Translation, ribosomal structure and biogenesis, ...
 4-92 7.20e-03

Protein N-acetyltransferase, RimJ/RimL family [Translation, ribosomal structure and biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 441276 [Multi-domain]  Cd Length: 173  Bit Score: 36.90  E-value: 7.20e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065467   4 LFEIIDNPDSSSPLWKQWKNLVDTEGWtsddnsVTEMVPSLPTTRSV-FAVTKTPERSMVGSVVWNEYDDI---CWLGfY 79
Cdd:COG1670   21 LAELLNDPEVARYLPGPPYSLEEARAW------LERLLADWADGGALpFAIEDKEDGELIGVVGLYDIDRAnrsAEIG-Y 93

                         90
                 ....*....|...
gi 351065467  80 LLAPEYRGKGIGS 92
Cdd:COG1670   94 WLAPAYWGKGYAT 106
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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