|
Name |
Accession |
Description |
Interval |
E-value |
| SrmB |
COG0513 |
Superfamily II DNA and RNA helicase [Replication, recombination and repair]; |
88-504 |
5.24e-132 |
|
Superfamily II DNA and RNA helicase [Replication, recombination and repair];
Pssm-ID: 440279 [Multi-domain] Cd Length: 420 Bit Score: 391.43 E-value: 5.24e-132
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 88 TKKFSQLGVCSWITQQLQTMQIKTATPVQAACIPKILEGSDILGCARTGTGKTLAFAIPILQKLSVDPYG-IYALILTPT 166
Cdd:COG0513 1 MMSFADLGLSPPLLKALAELGYTTPTPIQAQAIPLILAGRDVLGQAQTGTGKTAAFLLPLLQRLDPSRPRaPQALILAPT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 167 RELAFQIAEQFTALGKPITLKCSVIVGGRSLIHQARELSERPHVVVATPGRLADLIESDpdTIakVFKKIQFFVLDEADR 246
Cdd:COG0513 81 RELALQVAEELRKLAKYLGLRVATVYGGVSIGRQIRALKRGVDIVVATPGRLLDLIERG--AL--DLSGVETLVLDEADR 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 247 MLEGQYNDQLKPIFESISEKRQTLLLSATITNNINMLHRVSTRKPYFFEdkGKDDESTVDRLEQKYVVCPVAVKDAYLVY 326
Cdd:COG0513 157 MLDMGFIEDIERILKLLPKERQTLLFSATMPPEIRKLAKRYLKNPVRIE--VAPENATAETIEQRYYLVDKRDKLELLRR 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 327 VVKNYSEKnpksSVMIFAQTCRECQALAYMFEGLGFRVGSLHSQIPQKQRLAALSAFRSKTLQVIICTDVASRGLDIPHV 406
Cdd:COG0513 235 LLRDEDPE----RAIVFCNTKRGADRLAEKLQKRGISAAALHGDLSQGQRERALDAFRNGKIRVLVATDVAARGIDIDDV 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 407 DLVVNHNVPQCPKTYIHRVGRSARAGRFGSALSFVTQYDVELLQAVEQVIGKKLDELKV-SPKHVTKYVTQVLVAKKEAE 485
Cdd:COG0513 311 SHVINYDLPEDPEDYVHRIGRTGRAGAEGTAISLVTPDERRLLRAIEKLIGQKIEEEELpGFEPVEEKRLERLKPKIKEK 390
|
410
....*....|....*....
gi 351065690 486 LKLENQKFGEKKEINRRKE 504
Cdd:COG0513 391 LKGKKAGRGGRPGPKGERK 409
|
|
| DEADc_DDX49 |
cd17955 |
DEAD-box helicase domain of DEAD box protein 49; DDX49 (also called Dbp8) is a member of the ... |
91-295 |
5.80e-109 |
|
DEAD-box helicase domain of DEAD box protein 49; DDX49 (also called Dbp8) is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350713 [Multi-domain] Cd Length: 204 Bit Score: 324.18 E-value: 5.80e-109
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 91 FSQLGVCSWITQQLQTMQIKTATPVQAACIPKILEGSDILGCARTGTGKTLAFAIPILQKLSVDPYGIYALILTPTRELA 170
Cdd:cd17955 1 FEDLGLSSWLVKQCASLGIKEPTPIQKLCIPEILAGRDVIGGAKTGSGKTAAFALPILQRLSEDPYGIFALVLTPTRELA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 171 FQIAEQFTALGKPITLKCSVIVGGRSLIHQARELSERPHVVVATPGRLADLIESDPDTIaKVFKKIQFFVLDEADRMLEG 250
Cdd:cd17955 81 YQIAEQFRALGAPLGLRCCVIVGGMDMVKQALELSKRPHIVVATPGRLADHLRSSDDTT-KVLSRVKFLVLDEADRLLTG 159
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 351065690 251 QYNDQLKPIFESISEKRQTLLLSATITNNINMLHRVSTRKPYFFE 295
Cdd:cd17955 160 SFEDDLATILSALPPKRQTLLFSATLTDALKALKELFGNKPFFWE 204
|
|
| PRK11776 |
PRK11776 |
ATP-dependent RNA helicase DbpA; Provisional |
86-461 |
1.47e-79 |
|
ATP-dependent RNA helicase DbpA; Provisional
Pssm-ID: 236977 [Multi-domain] Cd Length: 460 Bit Score: 257.42 E-value: 1.47e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 86 MTTKKFSQLGVCSWITQQLQTMQIKTATPVQAACIPKILEGSDILGCARTGTGKTLAFAIPILQKLSVDPYGIYALILTP 165
Cdd:PRK11776 1 MSMTAFSTLPLPPALLANLNELGYTEMTPIQAQSLPAILAGKDVIAQAKTGSGKTAAFGLGLLQKLDVKRFRVQALVLCP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 166 TRELAFQIAEQFTALGKPI-TLKCSVIVGGRSLIHQARELSERPHVVVATPGRLADLIESDPDTIAKVfkkiQFFVLDEA 244
Cdd:PRK11776 81 TRELADQVAKEIRRLARFIpNIKVLTLCGGVPMGPQIDSLEHGAHIIVGTPGRILDHLRKGTLDLDAL----NTLVLDEA 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 245 DRMLEGQYNDQLKPIFESISEKRQTLLLSATITNNINMLHRVSTRKPYFFEDKGKDDESTVdrlEQKYVVCPVAVKDAYL 324
Cdd:PRK11776 157 DRMLDMGFQDAIDAIIRQAPARRQTLLFSATYPEGIAAISQRFQRDPVEVKVESTHDLPAI---EQRFYEVSPDERLPAL 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 325 VYVVKNYsekNPKSSVmIFAQTCRECQALAYMFEGLGFRVGSLHSQIPQKQRLAALSAFRSKTLQVIICTDVASRGLDIP 404
Cdd:PRK11776 234 QRLLLHH---QPESCV-VFCNTKKECQEVADALNAQGFSALALHGDLEQRDRDQVLVRFANRSCSVLVATDVAARGLDIK 309
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 351065690 405 HVDLVVNHNVPQCPKTYIHRVGRSARAGRFGSALSFVTQYDVELLQAVEQVIGKKLD 461
Cdd:PRK11776 310 ALEAVINYELARDPEVHVHRIGRTGRAGSKGLALSLVAPEEMQRANAIEDYLGRKLN 366
|
|
| DEADc |
cd00268 |
DEAD-box helicase domain of DEAD box helicases; DEAD-box helicases comprise a diverse family ... |
100-291 |
1.88e-74 |
|
DEAD-box helicase domain of DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350669 [Multi-domain] Cd Length: 196 Bit Score: 235.03 E-value: 1.88e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 100 ITQQLQTMQIKTATPVQAACIPKILEGSDILGCARTGTGKTLAFAIPILQKLSVDPY----GIYALILTPTRELAFQIAE 175
Cdd:cd00268 1 LLKALKKLGFEKPTPIQAQAIPLILSGRDVIGQAQTGSGKTLAFLLPILEKLLPEPKkkgrGPQALVLAPTRELAMQIAE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 176 QFTALGKPITLKCSVIVGGRSLIHQARELSERPHVVVATPGRLADLIESDpdtiAKVFKKIQFFVLDEADRMLEGQYNDQ 255
Cdd:cd00268 81 VARKLGKGTGLKVAAIYGGAPIKKQIEALKKGPDIVVGTPGRLLDLIERG----KLDLSNVKYLVLDEADRMLDMGFEED 156
|
170 180 190
....*....|....*....|....*....|....*.
gi 351065690 256 LKPIFESISEKRQTLLLSATITNNINMLHRVSTRKP 291
Cdd:cd00268 157 VEKILSALPKDRQTLLFSATLPEEVKELAKKFLKNP 192
|
|
| DEADc_DDX47 |
cd17954 |
DEAD-box helicase domain of DEAD box protein 47; DDX47 (also called E4-DEAD box protein) can ... |
91-291 |
7.44e-74 |
|
DEAD-box helicase domain of DEAD box protein 47; DDX47 (also called E4-DEAD box protein) can shuttle between the nucleus and the cytoplasm, and has an RNA-independent ATPase activity. DX47 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350712 [Multi-domain] Cd Length: 203 Bit Score: 233.75 E-value: 7.44e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 91 FSQLGVCSWITQQLQTMQIKTATPVQAACIPKILEGSDILGCARTGTGKTLAFAIPILQKLSVDPYGIYALILTPTRELA 170
Cdd:cd17954 2 FKELGVCEELCEACEKLGWKKPTKIQEEAIPVALQGRDIIGLAETGSGKTAAFALPILQALLENPQRFFALVLAPTRELA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 171 FQIAEQFTALGKPITLKCSVIVGGRSLIHQARELSERPHVVVATPGRLADLIEsdpDTIAKVFKKIQFFVLDEADRMLEG 250
Cdd:cd17954 82 QQISEQFEALGSSIGLKSAVLVGGMDMMAQAIALAKKPHVIVATPGRLVDHLE---NTKGFSLKSLKFLVMDEADRLLNM 158
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 351065690 251 QYNDQLKPIFESISEKRQTLLLSATITNNINMLHRVSTRKP 291
Cdd:cd17954 159 DFEPEIDKILKVIPRERTTYLFSATMTTKVAKLQRASLKNP 199
|
|
| PRK11192 |
PRK11192 |
ATP-dependent RNA helicase SrmB; Provisional |
104-503 |
9.56e-67 |
|
ATP-dependent RNA helicase SrmB; Provisional
Pssm-ID: 236877 [Multi-domain] Cd Length: 434 Bit Score: 222.90 E-value: 9.56e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 104 LQTMQIKTATPVQAACIPKILEGSDILGCARTGTGKTLAFAIPILQKLsVD-------PYGIyaLILTPTRELAFQIAEQ 176
Cdd:PRK11192 16 LQDKGYTRPTAIQAEAIPPALDGRDVLGSAPTGTGKTAAFLLPALQHL-LDfprrksgPPRI--LILTPTRELAMQVADQ 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 177 FTALGKPITLKCSVIVGGRSLIHQARELSERPHVVVATPGRLADLIESDPdtiakvF--KKIQFFVLDEADRMLEGQYnd 254
Cdd:PRK11192 93 ARELAKHTHLDIATITGGVAYMNHAEVFSENQDIVVATPGRLLQYIKEEN------FdcRAVETLILDEADRMLDMGF-- 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 255 qlKPIFESIS-EKR---QTLLLSATITNN--INMLHRVSTrKPYFFedkgkddESTVDRLEQK------YVVCPVAVKDA 322
Cdd:PRK11192 165 --AQDIETIAaETRwrkQTLLFSATLEGDavQDFAERLLN-DPVEV-------EAEPSRRERKkihqwyYRADDLEHKTA 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 323 YLVYVVKnysEKNPKSSVmIFAQTCRECQALAYMFEGLGFRVGSLHSQIPQKQRLAALSAFRSKTLQVIICTDVASRGLD 402
Cdd:PRK11192 235 LLCHLLK---QPEVTRSI-VFVRTRERVHELAGWLRKAGINCCYLEGEMVQAKRNEAIKRLTDGRVNVLVATDVAARGID 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 403 IPHVDLVVNHNVPQCPKTYIHRVGRSARAGRFGSALSFVTQYDVELLQAVEQVIGKKL-----DELKVSPKHVTKYVTQV 477
Cdd:PRK11192 311 IDDVSHVINFDMPRSADTYLHRIGRTGRAGRKGTAISLVEAHDHLLLGKIERYIEEPLkarviDELRPKTKAPSEKKTGK 390
|
410 420
....*....|....*....|....*.
gi 351065690 478 LVAKKEAELKLENQKFGEKKEINRRK 503
Cdd:PRK11192 391 PSKKVLAKRAEKKEKEKEKPKVKKRH 416
|
|
| PTZ00424 |
PTZ00424 |
helicase 45; Provisional |
115-474 |
4.91e-62 |
|
helicase 45; Provisional
Pssm-ID: 185609 [Multi-domain] Cd Length: 401 Bit Score: 209.68 E-value: 4.91e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 115 VQAACIPKILEGSDILGCARTGTGKTLAFAIPILQKLSVDPYGIYALILTPTRELAFQIAEQFTALGKPITLKCSVIVGG 194
Cdd:PTZ00424 54 IQQRGIKPILDGYDTIGQAQSGTGKTATFVIAALQLIDYDLNACQALILAPTRELAQQIQKVVLALGDYLKVRCHACVGG 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 195 RSLIHQARELSERPHVVVATPGRLADLIESDpdtiAKVFKKIQFFVLDEADRMLEGQYNDQLKPIFESISEKRQTLLLSA 274
Cdd:PTZ00424 134 TVVRDDINKLKAGVHMVVGTPGRVYDMIDKR----HLRVDDLKLFILDEADEMLSRGFKGQIYDVFKKLPPDVQVALFSA 209
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 275 TITNNINMLHRVSTRKPYFFedKGKDDESTVDRLEQKYVVCPvavKDAYLVYVVKNYSEKNPKSSVMIFAQTCRECQALA 354
Cdd:PTZ00424 210 TMPNEILELTTKFMRDPKRI--LVKKDELTLEGIRQFYVAVE---KEEWKFDTLCDLYETLTITQAIIYCNTRRKVDYLT 284
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 355 YMFEGLGFRVGSLHSQIPQKQRLAALSAFRSKTLQVIICTDVASRGLDIPHVDLVVNHNVPQCPKTYIHRVGRSARAGRF 434
Cdd:PTZ00424 285 KKMHERDFTVSCMHGDMDQKDRDLIMREFRSGSTRVLITTDLLARGIDVQQVSLVINYDLPASPENYIHRIGRSGRFGRK 364
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 351065690 435 GSALSFVTQYDVELLQAVEQVIGKKLDELkvsPKHVTKYV 474
Cdd:PTZ00424 365 GVAINFVTPDDIEQLKEIERHYNTQIEEM---PMEVADYL 401
|
|
| PRK01297 |
PRK01297 |
ATP-dependent RNA helicase RhlB; Provisional |
75-476 |
5.76e-62 |
|
ATP-dependent RNA helicase RhlB; Provisional
Pssm-ID: 234938 [Multi-domain] Cd Length: 475 Bit Score: 211.31 E-value: 5.76e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 75 TPKPIQ-------ISEDNMTTKKFSQLGVCSWITQQLQTMQIKTATPVQAACIPKILEGSDILGCARTGTGKTLAFAIPI 147
Cdd:PRK01297 66 KPKPASlwkledfVVEPQEGKTRFHDFNLAPELMHAIHDLGFPYCTPIQAQVLGYTLAGHDAIGRAQTGTGKTAAFLISI 145
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 148 LQKLSVDPYG-------IYALILTPTRELAFQIAEQFTALGKPITLKCSVIVGGRSLIHQARELSER-PHVVVATPGRLA 219
Cdd:PRK01297 146 INQLLQTPPPkerymgePRALIIAPTRELVVQIAKDAAALTKYTGLNVMTFVGGMDFDKQLKQLEARfCDILVATPGRLL 225
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 220 DLIESdpdtiAKV-FKKIQFFVLDEADRMLEGQYNDQLKPIFESISEK--RQTLLLSATITNNINMLHRVSTRKPYFFED 296
Cdd:PRK01297 226 DFNQR-----GEVhLDMVEVMVLDEADRMLDMGFIPQVRQIIRQTPRKeeRQTLLFSATFTDDVMNLAKQWTTDPAIVEI 300
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 297 KGKDDEStvDRLEQKyvVCPVAVKDAY-LVYvvkNYSEKNPKSSVMIFAQTCRECQALAYMFEGLGFRVGSLHSQIPQKQ 375
Cdd:PRK01297 301 EPENVAS--DTVEQH--VYAVAGSDKYkLLY---NLVTQNPWERVMVFANRKDEVRRIEERLVKDGINAAQLSGDVPQHK 373
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 376 RLAALSAFRSKTLQVIICTDVASRGLDIPHVDLVVNHNVPQCPKTYIHRVGRSARAGRFGSALSFVTQYDVELLQAVEQV 455
Cdd:PRK01297 374 RIKTLEGFREGKIRVLVATDVAGRGIHIDGISHVINFTLPEDPDDYVHRIGRTGRAGASGVSISFAGEDDAFQLPEIEEL 453
|
410 420
....*....|....*....|.
gi 351065690 456 IGKKLDeLKVSPKHVTKYVTQ 476
Cdd:PRK01297 454 LGRKIS-CEMPPAELLKPVPR 473
|
|
| PRK10590 |
PRK10590 |
ATP-dependent RNA helicase RhlE; Provisional |
91-460 |
1.90e-59 |
|
ATP-dependent RNA helicase RhlE; Provisional
Pssm-ID: 236722 [Multi-domain] Cd Length: 456 Bit Score: 204.27 E-value: 1.90e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 91 FSQLGVCSWITQQLQTMQIKTATPVQAACIPKILEGSDILGCARTGTGKTLAFAIPILQKLSVDPYG------IYALILT 164
Cdd:PRK10590 3 FDSLGLSPDILRAVAEQGYREPTPIQQQAIPAVLEGRDLMASAQTGTGKTAGFTLPLLQHLITRQPHakgrrpVRALILT 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 165 PTRELAFQIAEQFTALGKPITLKCSVIVGGRSLIHQARELSERPHVVVATPGRLADLIESDpdtiAKVFKKIQFFVLDEA 244
Cdd:PRK10590 83 PTRELAAQIGENVRDYSKYLNIRSLVVFGGVSINPQMMKLRGGVDVLVATPGRLLDLEHQN----AVKLDQVEILVLDEA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 245 DRMLEGQYNDQLKPIFESISEKRQTLLLSATITNNINMLHRVSTRKPYFFEDKGKDDEStvDRLEQKYVVCPVAVKDAYL 324
Cdd:PRK10590 159 DRMLDMGFIHDIRRVLAKLPAKRQNLLFSATFSDDIKALAEKLLHNPLEIEVARRNTAS--EQVTQHVHFVDKKRKRELL 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 325 VYVVKnyseKNPKSSVMIFAQTCRECQALAYMFEGLGFRVGSLHSQIPQKQRLAALSAFRSKTLQVIICTDVASRGLDIP 404
Cdd:PRK10590 237 SQMIG----KGNWQQVLVFTRTKHGANHLAEQLNKDGIRSAAIHGNKSQGARTRALADFKSGDIRVLVATDIAARGLDIE 312
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 351065690 405 HVDLVVNHNVPQCPKTYIHRVGRSARAGRFGSALSFVTQYDVELLQAVEQVIGKKL 460
Cdd:PRK10590 313 ELPHVVNYELPNVPEDYVHRIGRTGRAAATGEALSLVCVDEHKLLRDIEKLLKKEI 368
|
|
| DEAD |
pfam00270 |
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ... |
113-283 |
8.63e-59 |
|
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.
Pssm-ID: 425570 [Multi-domain] Cd Length: 165 Bit Score: 192.84 E-value: 8.63e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 113 TPVQAACIPKILEGSDILGCARTGTGKTLAFAIPILQKLSVDPYGIYALILTPTRELAFQIAEQFTALGKPITLKCSVIV 192
Cdd:pfam00270 1 TPIQAEAIPAILEGRDVLVQAPTGSGKTLAFLLPALEALDKLDNGPQALVLAPTRELAEQIYEELKKLGKGLGLKVASLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 193 GGRSLIHQARELsERPHVVVATPGRLADLIEsdpdtIAKVFKKIQFFVLDEADRMLEGQYNDQLKPIFESISEKRQTLLL 272
Cdd:pfam00270 81 GGDSRKEQLEKL-KGPDILVGTPGRLLDLLQ-----ERKLLKNLKLLVLDEAHRLLDMGFGPDLEEILRRLPKKRQILLL 154
|
170
....*....|.
gi 351065690 273 SATITNNINML 283
Cdd:pfam00270 155 SATLPRNLEDL 165
|
|
| DEADc_DDX24 |
cd17946 |
DEAD-box helicase domain of DEAD box protein 24; The human DDX24 gene encodes a DEAD box ... |
100-308 |
6.98e-58 |
|
DEAD-box helicase domain of DEAD box protein 24; The human DDX24 gene encodes a DEAD box protein, which shows little similarity to any of the other known human DEAD box proteins, but shows a high similarity to mouse Ddx24 at the amino acid level. MDM2 mediates nonproteolytic polyubiquitylation of the DEAD-Box RNA helicase DDX24. DDX24 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP- binding region.
Pssm-ID: 350704 [Multi-domain] Cd Length: 235 Bit Score: 193.22 E-value: 6.98e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 100 ITQQLQTMQIKTATPVQAACIPKIL-EGSDILGCARTGTGKTLAFAIPILQKL-----SVDPYGI----YALILTPTREL 169
Cdd:cd17946 1 ILRALADLGFSEPTPIQALALPAAIrDGKDVIGAAETGSGKTLAFGIPILERLlsqksSNGVGGKqkplRALILTPTREL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 170 AFQIAEQFTALGKPITLKCSVIVGGRSLIHQARELSERPHVVVATPGRLADLIESDPDTIAKvFKKIQFFVLDEADRMLE 249
Cdd:cd17946 81 AVQVKDHLKAIAKYTNIKIASIVGGLAVQKQERLLKKRPEIVVATPGRLWELIQEGNEHLAN-LKSLRFLVLDEADRMLE 159
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 351065690 250 GQYNDQLKPIFESI-------SEKRQTLLLSATITNNINMLHRVSTRKPYFFEDKGKDDESTVDRL 308
Cdd:cd17946 160 KGHFAELEKILELLnkdragkKRKRQTFVFSATLTLDHQLPLKLNSKKKKKKKEKKQKLELLIEKV 225
|
|
| PRK11634 |
PRK11634 |
ATP-dependent RNA helicase DeaD; Provisional |
91-456 |
7.09e-58 |
|
ATP-dependent RNA helicase DeaD; Provisional
Pssm-ID: 236941 [Multi-domain] Cd Length: 629 Bit Score: 203.93 E-value: 7.09e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 91 FSQLGVCSWITQQLQTMQIKTATPVQAACIPKILEGSDILGCARTGTGKTLAFAIPILQKLSVDPYGIYALILTPTRELA 170
Cdd:PRK11634 8 FADLGLKAPILEALNDLGYEKPSPIQAECIPHLLNGRDVLGMAQTGSGKTAAFSLPLLHNLDPELKAPQILVLAPTRELA 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 171 FQIAEQFTALGKPI-TLKCSVIVGGRSLIHQARELSERPHVVVATPGRLADLIESDPDTIAkvfkKIQFFVLDEADRMLE 249
Cdd:PRK11634 88 VQVAEAMTDFSKHMrGVNVVALYGGQRYDVQLRALRQGPQIVVGTPGRLLDHLKRGTLDLS----KLSGLVLDEADEMLR 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 250 GQYNDQLKPIFESISEKRQTLLLSATITNNINMLHRVSTRKPYffEDKGKDDESTVDRLEQKYVVCPVAVKDAYLVyvvk 329
Cdd:PRK11634 164 MGFIEDVETIMAQIPEGHQTALFSATMPEAIRRITRRFMKEPQ--EVRIQSSVTTRPDISQSYWTVWGMRKNEALV---- 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 330 NYSEKNPKSSVMIFAQTCRECQALAYMFEGLGFRVGSLHSQIPQKQRLAALSAFRSKTLQVIICTDVASRGLDIPHVDLV 409
Cdd:PRK11634 238 RFLEAEDFDAAIIFVRTKNATLEVAEALERNGYNSAALNGDMNQALREQTLERLKDGRLDILIATDVAARGLDVERISLV 317
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 351065690 410 VNHNVPQCPKTYIHRVGRSARAGRFGSALSFVTQYDVELLQAVEQVI 456
Cdd:PRK11634 318 VNYDIPMDSESYVHRIGRTGRAGRAGRALLFVENRERRLLRNIERTM 364
|
|
| PTZ00110 |
PTZ00110 |
helicase; Provisional |
74-463 |
7.46e-58 |
|
helicase; Provisional
Pssm-ID: 240273 [Multi-domain] Cd Length: 545 Bit Score: 202.31 E-value: 7.46e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 74 DTPKPIQisednmttkKFSQLGVCSWITQQLQTMQIKTATPVQAACIPKILEGSDILGCARTGTGKTLAFAIPILQKLSV 153
Cdd:PTZ00110 124 NVPKPVV---------SFEYTSFPDYILKSLKNAGFTEPTPIQVQGWPIALSGRDMIGIAETGSGKTLAFLLPAIVHINA 194
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 154 DPY-----GIYALILTPTRELAFQIAEQFTALGKPITLKCSVIVGGRSLIHQARELSERPHVVVATPGRLADLIESDPDT 228
Cdd:PTZ00110 195 QPLlrygdGPIVLVLAPTRELAEQIREQCNKFGASSKIRNTVAYGGVPKRGQIYALRRGVEILIACPGRLIDFLESNVTN 274
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 229 IAKVfkkiQFFVLDEADRMLEGQYNDQLKPIFESISEKRQTLLLSATITNNINMLHRVSTRKPYFFEDKGKDDESTVDRL 308
Cdd:PTZ00110 275 LRRV----TYLVLDEADRMLDMGFEPQIRKIVSQIRPDRQTLMWSATWPKEVQSLARDLCKEEPVHVNVGSLDLTACHNI 350
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 309 EQKYVVCPVAVKDAYLVYVVKNYSEKNPKssVMIFAQTCRECQALAYMFEGLGFRVGSLHSQIPQKQRLAALSAFRSKTL 388
Cdd:PTZ00110 351 KQEVFVVEEHEKRGKLKMLLQRIMRDGDK--ILIFVETKKGADFLTKELRLDGWPALCIHGDKKQEERTWVLNEFKTGKS 428
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 389 QVIICTDVASRGLDIPHVDLVVNHNVPQCPKTYIHRVGRSARAGRFGSALSFVT--QYD-----VELLQAVEQVIGKKLD 461
Cdd:PTZ00110 429 PIMIATDVASRGLDVKDVKYVINFDFPNQIEDYVHRIGRTGRAGAKGASYTFLTpdKYRlardlVKVLREAKQPVPPELE 508
|
..
gi 351065690 462 EL 463
Cdd:PTZ00110 509 KL 510
|
|
| DEADc_DDX27 |
cd17947 |
DEAD-box helicase domain of DEAD box protein 27; DDX27 (also called RHLP, deficiency of ... |
104-291 |
3.61e-56 |
|
DEAD-box helicase domain of DEAD box protein 27; DDX27 (also called RHLP, deficiency of ribosomal subunits protein 1 homolog, and probable ATP-dependent RNA helicase DDX27) is involved in the processing of 5.8S and 28S ribosomal RNAs. More specifically, the encoded protein localizes to the nucleolus, where it interacts with the PeBoW complex to ensure proper 3' end formation of 47S rRNA. DDX27 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350705 [Multi-domain] Cd Length: 196 Bit Score: 187.08 E-value: 3.61e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 104 LQTMQIKTATPVQAACIPKILEGSDILGCARTGTGKTLAFAIPILQKLSVDPY---GIYALILTPTRELAFQIAEQFTAL 180
Cdd:cd17947 5 LSSLGFTKPTPIQAAAIPLALLGKDICASAVTGSGKTAAFLLPILERLLYRPKkkaATRVLVLVPTRELAMQCFSVLQQL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 181 GKPITLKCSVIVGGRSLIHQARELSERPHVVVATPGRLADLIESDPdtiAKVFKKIQFFVLDEADRMLEGQYNDQLKPIF 260
Cdd:cd17947 85 AQFTDITFALAVGGLSLKAQEAALRARPDIVIATPGRLIDHLRNSP---SFDLDSIEILVLDEADRMLEEGFADELKEIL 161
|
170 180 190
....*....|....*....|....*....|.
gi 351065690 261 ESISEKRQTLLLSATITNNINMLHRVSTRKP 291
Cdd:cd17947 162 RLCPRTRQTMLFSATMTDEVKDLAKLSLNKP 192
|
|
| PRK04537 |
PRK04537 |
ATP-dependent RNA helicase RhlB; Provisional |
81-460 |
2.58e-53 |
|
ATP-dependent RNA helicase RhlB; Provisional
Pssm-ID: 235307 [Multi-domain] Cd Length: 572 Bit Score: 190.55 E-value: 2.58e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 81 ISEDNMTTKKFSQLGVCSWITQQLQTMQIKTATPVQAACIPKILEGSDILGCARTGTGKTLAFAIPILQKL-------SV 153
Cdd:PRK04537 1 MSDKPLTDLTFSSFDLHPALLAGLESAGFTRCTPIQALTLPVALPGGDVAGQAQTGTGKTLAFLVAVMNRLlsrpalaDR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 154 DPYGIYALILTPTRELAFQIAEQFTALGKPITLKCSVIVGGRSLIHQARELSERPHVVVATPGRLADLIESDpdtiaKV- 232
Cdd:PRK04537 81 KPEDPRALILAPTRELAIQIHKDAVKFGADLGLRFALVYGGVDYDKQRELLQQGVDVIIATPGRLIDYVKQH-----KVv 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 233 -FKKIQFFVLDEADRMLEGQYNDQLKPIFESISEK--RQTLLLSATITNNINMLHRVSTRKPyffEDKGKDDES-TVDRL 308
Cdd:PRK04537 156 sLHACEICVLDEADRMFDLGFIKDIRFLLRRMPERgtRQTLLFSATLSHRVLELAYEHMNEP---EKLVVETETiTAARV 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 309 EQKyVVCPVAVKDAYLVYVVKNYSEKnpkSSVMIFAQTCRECQALAYMFEGLGFRVGSLHSQIPQKQRLAALSAFRSKTL 388
Cdd:PRK04537 233 RQR-IYFPADEEKQTLLLGLLSRSEG---ARTMVFVNTKAFVERVARTLERHGYRVGVLSGDVPQKKRESLLNRFQKGQL 308
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 351065690 389 QVIICTDVASRGLDIPHVDLVVNHNVPQCPKTYIHRVGRSARAGRFGSALSFVTQYDVELLQAVEQVIGKKL 460
Cdd:PRK04537 309 EILVATDVAARGLHIDGVKYVYNYDLPFDAEDYVHRIGRTARLGEEGDAISFACERYAMSLPDIEAYIEQKI 380
|
|
| DEADc_DDX54 |
cd17959 |
DEAD-box helicase domain of DEAD box protein 54; DDX54 interacts in a hormone-dependent manner ... |
110-291 |
5.05e-53 |
|
DEAD-box helicase domain of DEAD box protein 54; DDX54 interacts in a hormone-dependent manner with nuclear receptors, and represses their transcriptional activity. DDX54 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350717 [Multi-domain] Cd Length: 205 Bit Score: 179.42 E-value: 5.05e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 110 KTATPVQAACIPKILEGSDILGCARTGTGKTLAFAIPILQKL--SVDPYGIYALILTPTRELAFQIAEQFTALGKPITLK 187
Cdd:cd17959 22 KVPTPIQRKTIPLILDGRDVVAMARTGSGKTAAFLIPMIEKLkaHSPTVGARALILSPTRELALQTLKVTKELGKFTDLR 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 188 CSVIVGGRSLIHQARELSERPHVVVATPGRLADLIESDPDTIakvfKKIQFFVLDEADRMLEGQYNDQLKPIFESISEKR 267
Cdd:cd17959 102 TALLVGGDSLEEQFEALASNPDIIIATPGRLLHLLVEMNLKL----SSVEYVVFDEADRLFEMGFAEQLHEILSRLPENR 177
|
170 180
....*....|....*....|....
gi 351065690 268 QTLLLSATITNNINMLHRVSTRKP 291
Cdd:cd17959 178 QTLLFSATLPKLLVEFAKAGLNEP 201
|
|
| DEADc_DDX10 |
cd17941 |
DEAD-box helicase domain of DEAD box protein 10; Fusion of the DDX10 gene and the nucleoporin ... |
104-293 |
5.11e-53 |
|
DEAD-box helicase domain of DEAD box protein 10; Fusion of the DDX10 gene and the nucleoporin gene, NUP98, by inversion 11 (p15q22) chromosome translocation is found in the patients with de novo or therapy-related myeloid malignancies. Diseases associated with DDX10 (also known as DDX10-NUP98 Fusion Protein Type 2) include myelodysplastic syndrome and leukemia, acute myeloid. DDX10 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350699 [Multi-domain] Cd Length: 198 Bit Score: 179.02 E-value: 5.11e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 104 LQTMQIKTATPVQAACIPKILEGSDILGCARTGTGKTLAFAIPILQKLSVDPY----GIYALILTPTRELAFQIAEQFTA 179
Cdd:cd17941 5 LKEAGFIKMTEIQRDSIPHALQGRDILGAAKTGSGKTLAFLVPLLEKLYRERWtpedGLGALIISPTRELAMQIFEVLRK 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 180 LGKPITLKCSVIVGGRSLIHQARELSERpHVVVATPGRLADLIESDPDTiakVFKKIQFFVLDEADRMLEGQYNDQLKPI 259
Cdd:cd17941 85 VGKYHSFSAGLIIGGKDVKEEKERINRM-NILVCTPGRLLQHMDETPGF---DTSNLQMLVLDEADRILDMGFKETLDAI 160
|
170 180 190
....*....|....*....|....*....|....
gi 351065690 260 FESISEKRQTLLLSATITNNINMLHRVSTRKPYF 293
Cdd:cd17941 161 VENLPKSRQTLLFSATQTKSVKDLARLSLKNPEY 194
|
|
| PRK04837 |
PRK04837 |
ATP-dependent RNA helicase RhlB; Provisional |
82-457 |
3.88e-52 |
|
ATP-dependent RNA helicase RhlB; Provisional
Pssm-ID: 235314 [Multi-domain] Cd Length: 423 Bit Score: 183.63 E-value: 3.88e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 82 SEDNMTTKKFSQLGVCSWITQQLQTMQIKTATPVQAACIPKILEGSDILGCARTGTGKTLAFAIPILQKLSVDP------ 155
Cdd:PRK04837 1 SKTHLTEQKFSDFALHPQVVEALEKKGFHNCTPIQALALPLTLAGRDVAGQAQTGTGKTMAFLTATFHYLLSHPapedrk 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 156 -YGIYALILTPTRELAFQIAEQFTALGKPITLKCSVIVGGRSLIHQARELSERPHVVVATPGRLADLIESDpdtiakVF- 233
Cdd:PRK04837 81 vNQPRALIMAPTRELAVQIHADAEPLAQATGLKLGLAYGGDGYDKQLKVLESGVDILIGTTGRLIDYAKQN------HIn 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 234 -KKIQFFVLDEADRMLEGQYNDQLKPIFESISE--KRQTLLLSATITnninmlHRVstrKPYFFEDKgKDDESTVDRLEQ 310
Cdd:PRK04837 155 lGAIQVVVLDEADRMFDLGFIKDIRWLFRRMPPanQRLNMLFSATLS------YRV---RELAFEHM-NNPEYVEVEPEQ 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 311 KyvvCPVAVKDAyLVY-------------VVKNYSEKnpkssVMIFAQTCRECQALAYMFEGLGFRVGSLHSQIPQKQRL 377
Cdd:PRK04837 225 K---TGHRIKEE-LFYpsneekmrllqtlIEEEWPDR-----AIIFANTKHRCEEIWGHLAADGHRVGLLTGDVAQKKRL 295
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 378 AALSAFRSKTLQVIICTDVASRGLDIPHVDLVVNHNVPQCPKTYIHRVGRSARAGRFGSALSFVTQYDVELLQAVEQVIG 457
Cdd:PRK04837 296 RILEEFTRGDLDILVATDVAARGLHIPAVTHVFNYDLPDDCEDYVHRIGRTGRAGASGHSISLACEEYALNLPAIETYIG 375
|
|
| DEADc_MSS116 |
cd17964 |
DEAD-box helicase domain of DEAD-box helicase Mss116; Mss116 is an RNA chaperone important for ... |
104-294 |
4.39e-52 |
|
DEAD-box helicase domain of DEAD-box helicase Mss116; Mss116 is an RNA chaperone important for mitochondrial group I and II intron splicing, translational activation, and RNA end processing. Mss116 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350722 [Multi-domain] Cd Length: 211 Bit Score: 177.00 E-value: 4.39e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 104 LQTMQIKTATPVQAACIPKILE-GSDILGCARTGTGKTLAFAIPILQKL-----SVDPYGIYALILTPTRELAFQIAEQF 177
Cdd:cd17964 9 LTRMGFETMTPVQQKTLKPILStGDDVLARAKTGTGKTLAFLLPAIQSLlntkpAGRRSGVSALIISPTRELALQIAAEA 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 178 TALGKPIT-LKCSVIVGGRSLIHQAREL-SERPHVVVATPGRLADLIEsDPdTIAKVFKKIQFFVLDEADRMLEGQYNDQ 255
Cdd:cd17964 89 KKLLQGLRkLRVQSAVGGTSRRAELNRLrRGRPDILVATPGRLIDHLE-NP-GVAKAFTDLDYLVLDEADRLLDMGFRPD 166
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 351065690 256 LKPIFESI----SEKRQTLLLSATITNNINMLHRVSTRKPYFF 294
Cdd:cd17964 167 LEQILRHLpeknADPRQTLLFSATVPDEVQQIARLTLKKDYKF 209
|
|
| SF2_C_DEAD |
cd18787 |
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse ... |
308-441 |
5.09e-51 |
|
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis, and RNA degradation. They are superfamily (SF)2 helicases that, similar to SF1, do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350174 [Multi-domain] Cd Length: 131 Bit Score: 171.15 E-value: 5.09e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 308 LEQKYVVCPvavKDAYLVYVVKNYSEKNPKSSVMIFAQTCRECQALAYMFEGLGFRVGSLHSQIPQKQRLAALSAFRSKT 387
Cdd:cd18787 1 IKQLYVVVE---EEEKKLLLLLLLLEKLKPGKAIIFVNTKKRVDRLAELLEELGIKVAALHGDLSQEERERALKKFRSGK 77
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 351065690 388 LQVIICTDVASRGLDIPHVDLVVNHNVPQCPKTYIHRVGRSARAGRFGSALSFV 441
Cdd:cd18787 78 VRVLVATDVAARGLDIPGVDHVINYDLPRDAEDYVHRIGRTGRAGRKGTAITFV 131
|
|
| DEADc_DDX3_DDX4 |
cd17967 |
DEAD-box helicase domain of ATP-dependent RNA helicases DDX3 and DDX4; This subfamily includes ... |
91-283 |
3.79e-50 |
|
DEAD-box helicase domain of ATP-dependent RNA helicases DDX3 and DDX4; This subfamily includes Drosophila melanogaster Vasa, which is essential for development. DEAD box protein 3 (DDX3) has been reported to display a high level of RNA-independent ATPase activity stimulated by both RNA and DNA. DEAD box protein 4 (DDX4, also known as VASA homolog) is an ATP-dependent RNA helicase required during spermatogenesis and is essential for the germline integrity. DDX3 and DDX4 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350725 [Multi-domain] Cd Length: 221 Bit Score: 172.29 E-value: 3.79e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 91 FSQLGVCSWITQQLQTMQIKTATPVQAACIPKILEGSDILGCARTGTGKTLAFAIPILQKLSVDPYGIY----------A 160
Cdd:cd17967 2 FEEAGLRELLLENIKRAGYTKPTPVQKYAIPIILAGRDLMACAQTGSGKTAAFLLPIISKLLEDGPPSVgrgrrkaypsA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 161 LILTPTRELAFQI---AEQFtALGKPItlKCSVIVGGRSLIHQARELSERPHVVVATPGRLADLIESdpdtiAKV-FKKI 236
Cdd:cd17967 82 LILAPTRELAIQIyeeARKF-SYRSGV--RSVVVYGGADVVHQQLQLLRGCDILVATPGRLVDFIER-----GRIsLSSI 153
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 351065690 237 QFFVLDEADRMLEGQYNDQLKPIFESIS----EKRQTLLLSATITNNINML 283
Cdd:cd17967 154 KFLVLDEADRMLDMGFEPQIRKIVEHPDmppkGERQTLMFSATFPREIQRL 204
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
104-311 |
4.79e-46 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 160.74 E-value: 4.79e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 104 LQTMQIKTATPVQAACIPKILEG-SDILGCARTGTGKTLAFAIPILQKLSVDPyGIYALILTPTRELAFQIAEQFTALGK 182
Cdd:smart00487 1 IEKFGFEPLRPYQKEAIEALLSGlRDVILAAPTGSGKTLAALLPALEALKRGK-GGRVLVLVPTRELAEQWAEELKKLGP 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 183 PITLKCSVIVGGRSLIHQAREL-SERPHVVVATPGRLADLIESDPdtiaKVFKKIQFFVLDEADRMLEGQYNDQLKPIFE 261
Cdd:smart00487 80 SLGLKVVGLYGGDSKREQLRKLeSGKTDILVTTPGRLLDLLENDK----LSLSNVDLVILDEAHRLLDGGFGDQLEKLLK 155
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 351065690 262 SISEKRQTLLLSATITNNINMLHRVSTRKPYFFedkgKDDESTVDRLEQK 311
Cdd:smart00487 156 LLPKNVQLLLLSATPPEEIENLLELFLNDPVFI----DVGFTPLEPIEQF 201
|
|
| DEADc_DDX23 |
cd17945 |
DEAD-box helicase domain of DEAD box protein 23; DDX23 (also called U5 snRNP 100kD protein and ... |
100-291 |
6.15e-46 |
|
DEAD-box helicase domain of DEAD box protein 23; DDX23 (also called U5 snRNP 100kD protein and PRP28 homolog) is involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation. Diseases associated with DDX23 include distal hereditary motor neuropathy, type II. DDX23 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350703 [Multi-domain] Cd Length: 220 Bit Score: 160.95 E-value: 6.15e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 100 ITQQLQTMQIKTATPVQAACIPKILEGSDILGCARTGTGKTLAFAIPILQKLSVDPY--------GIYALILTPTRELAF 171
Cdd:cd17945 1 LLRVIRKLGYKEPTPIQRQAIPIGLQNRDIIGIAETGSGKTAAFLIPLLVYISRLPPldeetkddGPYALILAPTRELAQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 172 QIAEQFTALGKPITLKCSVIVGGRSLIHQARELSERPHVVVATPGRLADLIESDpdtiAKVFKKIQFFVLDEADRMLEGQ 251
Cdd:cd17945 81 QIEEETQKFAKPLGIRVVSIVGGHSIEEQAFSLRNGCEILIATPGRLLDCLERR----LLVLNQCTYVVLDEADRMIDMG 156
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 252 YNDQLKPIFESI--------------------SEKRQTLLLSATITNNINMLHRVSTRKP 291
Cdd:cd17945 157 FEPQVTKILDAMpvsnkkpdteeaeklaasgkHRYRQTMMFTATMPPAVEKIAKGYLRRP 216
|
|
| DEADc_DDX46 |
cd17953 |
DEAD-box helicase domain of DEAD box protein 46; DDX46 (also called Prp5-like DEAD-box protein) ... |
74-291 |
9.86e-45 |
|
DEAD-box helicase domain of DEAD box protein 46; DDX46 (also called Prp5-like DEAD-box protein) is a component of the 17S U2 snRNP complex. It plays an important role in pre-mRNA splicing and has a role in antiviral innate immunity. DDX46 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350711 [Multi-domain] Cd Length: 222 Bit Score: 157.54 E-value: 9.86e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 74 DTPKPIQisednmttkKFSQLGVCSWITQQLQTMQIKTATPVQAACIPKILEGSDILGCARTGTGKTLAFAIPIL----- 148
Cdd:cd17953 6 DCPKPIQ---------KWSQCGLSEKVLDLIKKLGYEKPTPIQAQALPAIMSGRDVIGIAKTGSGKTLAFLLPMFrhikd 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 149 QKLSVDPYGIYALILTPTRELAFQIAEQFTALGKPITLKCSVIVGGRSLIHQARELSERPHVVVATPGRLADLIESDPDT 228
Cdd:cd17953 77 QRPVKPGEGPIGLIMAPTRELALQIYVECKKFSKALGLRVVCVYGGSGISEQIAELKRGAEIVVCTPGRMIDILTANNGR 156
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 351065690 229 IAKVfKKIQFFVLDEADRMLEGQYNDQLKPIFESISEKRQTLLLSATITNNINMLHRVSTRKP 291
Cdd:cd17953 157 VTNL-RRVTYVVLDEADRMFDMGFEPQIMKIVNNIRPDRQTVLFSATFPRKVEALARKVLHKP 218
|
|
| DEADc_DDX20 |
cd17943 |
DEAD-box helicase domain of DEAD box protein 20; DDX20 (also called DEAD Box Protein DP 103, ... |
100-293 |
1.22e-44 |
|
DEAD-box helicase domain of DEAD box protein 20; DDX20 (also called DEAD Box Protein DP 103, Component Of Gems 3, Gemin-3, and SMN-Interacting Protein) interacts directly with SMN (survival of motor neurons), the spinal muscular atrophy gene product, and may play a catalytic role in the function of the SMN complex on ribonucleoproteins. Diseases associated with DDX20 include spinal muscular atrophy and muscular atrophy. DDX20 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350701 [Multi-domain] Cd Length: 192 Bit Score: 156.27 E-value: 1.22e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 100 ITQQLQTMQIKTATPVQAACIPKILEGSDILGCARTGTGKTLAFAIPILQKLSVDPYGIYALILTPTRELAFQIAEQFTA 179
Cdd:cd17943 1 VLEGLKAAGFQRPSPIQLAAIPLGLAGHDLIVQAKSGTGKTLVFVVIALESLDLERRHPQVLILAPTREIAVQIHDVFKK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 180 LGKPIT-LKCSVIVGGRSLIHQARELSeRPHVVVATPGRLADLIESDpdtiAKVFKKIQFFVLDEADRMLEGQYNDQLKP 258
Cdd:cd17943 81 IGKKLEgLKCEVFIGGTPVKEDKKKLK-GCHIAVGTPGRIKQLIELG----ALNVSHVRLFVLDEADKLMEGSFQKDVNW 155
|
170 180 190
....*....|....*....|....*....|....*.
gi 351065690 259 IFESISEKRQTLLLSATI-TNNINMLHRVsTRKPYF 293
Cdd:cd17943 156 IFSSLPKNKQVIAFSATYpKNLDNLLARY-MRKPVL 190
|
|
| DEADc_DDX31 |
cd17949 |
DEAD-box helicase domain of DEAD box protein 31; DDX31 (also called helicain or G2 helicase) ... |
105-293 |
2.63e-44 |
|
DEAD-box helicase domain of DEAD box protein 31; DDX31 (also called helicain or G2 helicase) plays a role in ribosome biogenesis and TP53/p53 regulation through its interaction with NPM1. DDX31 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350707 [Multi-domain] Cd Length: 214 Bit Score: 156.21 E-value: 2.63e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 105 QTMQIKTATPVQAACIPKILEGSDILGCARTGTGKTLAFAIPILQKL-SVDPY-----GIYALILTPTRELAFQIAEQFT 178
Cdd:cd17949 7 SKMGIEKPTAIQKLAIPVLLQGRDVLVRSQTGSGKTLAYLLPIIQRLlSLEPRvdrsdGTLALVLVPTRELALQIYEVLE 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 179 ALGKPIT-LKCSVIVGGRSLIHQARELSERPHVVVATPGRLADLIESdpdTIAKVFKKIQFFVLDEADRMLEGQYNDQLK 257
Cdd:cd17949 87 KLLKPFHwIVPGYLIGGEKRKSEKARLRKGVNILIATPGRLLDHLKN---TQSFDVSNLRWLVLDEADRLLDMGFEKDIT 163
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 351065690 258 PIFESISEK-------------RQTLLLSATITNNINMLHRVSTRKPYF 293
Cdd:cd17949 164 KILELLDDKrskaggekskpsrRQTVLVSATLTDGVKRLAGLSLKDPVY 212
|
|
| PLN00206 |
PLN00206 |
DEAD-box ATP-dependent RNA helicase; Provisional |
73-460 |
2.92e-44 |
|
DEAD-box ATP-dependent RNA helicase; Provisional
Pssm-ID: 215103 [Multi-domain] Cd Length: 518 Bit Score: 164.58 E-value: 2.92e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 73 DDTPKPIQisednmttkKFSQLGVCSWITQQLQTMQIKTATPVQAACIPKILEGSDILGCARTGTGKTLAFAIPILQKL- 151
Cdd:PLN00206 114 EAVPPPIL---------SFSSCGLPPKLLLNLETAGYEFPTPIQMQAIPAALSGRSLLVSADTGSGKTASFLVPIISRCc 184
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 152 ------SVDPYGIYALILTPTRELAFQIAEQFTALGKPITLKCSVIVGGRSLIHQARELSERPHVVVATPGRLADLIESD 225
Cdd:PLN00206 185 tirsghPSEQRNPLAMVLTPTRELCVQVEDQAKVLGKGLPFKTALVVGGDAMPQQLYRIQQGVELIVGTPGRLIDLLSKH 264
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 226 PDTIAKVFkkiqFFVLDEADRMLEGQYNDQLKPIFESISEKrQTLLLSATITNNINMLHRvSTRKPYFFEDKGKDDESTv 305
Cdd:PLN00206 265 DIELDNVS----VLVLDEVDCMLERGFRDQVMQIFQALSQP-QVLLFSATVSPEVEKFAS-SLAKDIILISIGNPNRPN- 337
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 306 DRLEQKYVVCPVAVKDAYLVYVVKNYSEKNPKSSVMIFAQTCRECQALAyMFEGLGFRVGSLHSQIPQKQRLAALSAFRS 385
Cdd:PLN00206 338 KAVKQLAIWVETKQKKQKLFDILKSKQHFKPPAVVFVSSRLGADLLANA-ITVVTGLKALSIHGEKSMKERREVMKSFLV 416
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 386 KTLQVIICTDVASRGLDIPHVDLVVNHNVPQCPKTYIHRVGRSARAGRFGSALSFVTQYD-------VELLQAVEQVIGK 458
Cdd:PLN00206 417 GEVPVIVATGVLGRGVDLLRVRQVIIFDMPNTIKEYIHQIGRASRMGEKGTAIVFVNEEDrnlfpelVALLKSSGAAIPR 496
|
..
gi 351065690 459 KL 460
Cdd:PLN00206 497 EL 498
|
|
| DEADc_DDX56 |
cd17961 |
DEAD-box helicase domain of DEAD box protein 56; DDX56 is a helicase required for assembly of ... |
100-283 |
1.46e-43 |
|
DEAD-box helicase domain of DEAD box protein 56; DDX56 is a helicase required for assembly of infectious West Nile virus particles. New research suggests that DDX56 relocalizes to the site of virus assembly during WNV infection and that its interaction with WNV capsid in the cytoplasm may occur transiently during virion morphogenesis. DDX56 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350719 [Multi-domain] Cd Length: 206 Bit Score: 153.89 E-value: 1.46e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 100 ITQQLQTMQIKTATPVQAACIPKILEGSDILGCARTGTGKTLAFAIPILQKL------SVDPYGIYALILTPTRELAFQI 173
Cdd:cd17961 5 LLKAIAKLGWEKPTLIQSKAIPLALEGKDILARARTGSGKTAAYALPIIQKIlkakaeSGEEQGTRALILVPTRELAQQV 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 174 AEQFTALgkpiTLKCSV------IVGGRSLIHQARELSERPHVVVATPGRLADLIESDpdtIAKVFKKIQFFVLDEADRM 247
Cdd:cd17961 85 SKVLEQL----TAYCRKdvrvvnLSASSSDSVQRALLAEKPDIVVSTPARLLSHLESG---SLLLLSTLKYLVIDEADLV 157
|
170 180 190
....*....|....*....|....*....|....*.
gi 351065690 248 LEGQYNDQLKPIFESISEKRQTLLLSATITNNINML 283
Cdd:cd17961 158 LSYGYEEDLKSLLSYLPKNYQTFLMSATLSEDVEAL 193
|
|
| DEADc_DDX55 |
cd17960 |
DEAD-box helicase domain of DEAD box protein 55; DDX55 is a member of the DEAD-box helicases, ... |
104-291 |
5.39e-43 |
|
DEAD-box helicase domain of DEAD box protein 55; DDX55 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350718 [Multi-domain] Cd Length: 202 Bit Score: 152.34 E-value: 5.39e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 104 LQTMQIKTATPVQAACIPKILEGSDILGCARTGTGKTLAFAIPILQKL-----SVDPYGIYALILTPTRELAFQI---AE 175
Cdd:cd17960 5 VAELGFTSMTPVQAATIPLFLSNKDVVVEAVTGSGKTLAFLIPVLEILlkrkaNLKKGQVGALIISPTRELATQIyevLQ 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 176 QFTALGKPiTLKCSVIVGGRSLIHQARELSE-RPHVVVATPGRLADLIESDPDTIAkvFKKIQFFVLDEADRMLEGQYND 254
Cdd:cd17960 85 SFLEHHLP-KLKCQLLIGGTNVEEDVKKFKRnGPNILVGTPGRLEELLSRKADKVK--VKSLEVLVLDEADRLLDLGFEA 161
|
170 180 190
....*....|....*....|....*....|....*..
gi 351065690 255 QLKPIFESISEKRQTLLLSATITNNINMLHRVSTRKP 291
Cdd:cd17960 162 DLNRILSKLPKQRRTGLFSATQTDAVEELIKAGLRNP 198
|
|
| DEADc_DDX51 |
cd17956 |
DEAD-box helicase domain of DEAD box protein 51; DDX51 aids cell cancer proliferation by ... |
102-294 |
4.98e-42 |
|
DEAD-box helicase domain of DEAD box protein 51; DDX51 aids cell cancer proliferation by regulating multiple signalling pathways. Mammalian DEAD box protein Ddx51 acts in 3' end maturation of 28S rRNA by promoting the release of U8 snoRNA.It is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350714 [Multi-domain] Cd Length: 231 Bit Score: 150.86 E-value: 4.98e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 102 QQLQTMQIKTATPVQAACIPKILEGS---------DILGCARTGTGKTLAFAIPILQKLS--VDPYgIYALILTPTRELA 170
Cdd:cd17956 3 KNLQNNGITSAFPVQAAVIPWLLPSSkstppyrpgDLCVSAPTGSGKTLAYVLPIVQALSkrVVPR-LRALIVVPTKELV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 171 FQIAEQFTALGKPITLKCSVIVGGRSLIHQARELSE--------RPHVVVATPGRLADLIESDPDTIakvFKKIQFFVLD 242
Cdd:cd17956 82 QQVYKVFESLCKGTGLKVVSLSGQKSFKKEQKLLLVdtsgrylsRVDILVATPGRLVDHLNSTPGFT---LKHLRFLVID 158
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 351065690 243 EADRMLEGQYNDQL----KPIFESISEKR----------------QTLLLSATITNNINMLHRVSTRKPYFF 294
Cdd:cd17956 159 EADRLLNQSFQDWLetvmKALGRPTAPDLgsfgdanllersvrplQKLLFSATLTRDPEKLSSLKLHRPRLF 230
|
|
| DEADc_DDX18 |
cd17942 |
DEAD-box helicase domain of DEAD box protein 18; This DDX18 gene encodes a DEAD box protein ... |
104-291 |
7.40e-42 |
|
DEAD-box helicase domain of DEAD box protein 18; This DDX18 gene encodes a DEAD box protein and is activated by Myc protein. DDX18 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350700 [Multi-domain] Cd Length: 198 Bit Score: 149.05 E-value: 7.40e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 104 LQTMQIKTATPVQAACIPKILEGSDILGCARTGTGKTLAFAIP---ILQKLSVDPY-GIYALILTPTRELAFQIAEQFTA 179
Cdd:cd17942 5 IEEMGFTKMTEIQAKSIPPLLEGRDVLGAAKTGSGKTLAFLIPaieLLYKLKFKPRnGTGVIIISPTRELALQIYGVAKE 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 180 LGKPITLKCSVIVGGRSLIHQARELSERPHVVVATPGRLADLIESDPDTIakvFKKIQFFVLDEADRMLEGQYNDQLKPI 259
Cdd:cd17942 85 LLKYHSQTFGIVIGGANRKAEAEKLGKGVNILVATPGRLLDHLQNTKGFL---YKNLQCLIIDEADRILEIGFEEEMRQI 161
|
170 180 190
....*....|....*....|....*....|..
gi 351065690 260 FESISEKRQTLLLSATITNNINMLHRVSTRKP 291
Cdd:cd17942 162 IKLLPKRRQTMLFSATQTRKVEDLARISLKKK 193
|
|
| DEADc_DDX4 |
cd18052 |
DEAD-box helicase domain of DEAD box protein 4; DEAD box protein 4 (DDX4, also known as VASA ... |
71-294 |
9.87e-42 |
|
DEAD-box helicase domain of DEAD box protein 4; DEAD box protein 4 (DDX4, also known as VASA homolog) is an ATP-dependent RNA helicase required during spermatogenesis and is essential for the germline integrity. DEAD-box helicases are a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350810 [Multi-domain] Cd Length: 264 Bit Score: 150.89 E-value: 9.87e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 71 SSDDTPKPIQisednmttkKFSQLGVCSWITQQLQTMQIKTATPVQAACIPKILEGSDILGCARTGTGKTLAFAIPILQK 150
Cdd:cd18052 34 TGRNPPPAIL---------TFEEANLCETLLKNIRKAGYEKPTPVQKYAIPIILAGRDLMACAQTGSGKTAAFLLPVLTG 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 151 LSVDpyGI-----------YALILTPTRELAFQI---AEQFtALGKPItlKCSVIVGGRSLIHQARELSERPHVVVATPG 216
Cdd:cd18052 105 MMKE--GLtassfsevqepQALIVAPTRELANQIfleARKF-SYGTCI--RPVVVYGGVSVGHQIRQIEKGCHILVATPG 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 217 RLADLIESdpdtiAKV-FKKIQFFVLDEADRMLEGQYNDQLKPIFESIS----EKRQTLLLSATITNNINMLHRVSTRKP 291
Cdd:cd18052 180 RLLDFIGR-----GKIsLSKLKYLILDEADRMLDMGFGPEIRKLVSEPGmpskEDRQTLMFSATFPEEIQRLAAEFLKED 254
|
...
gi 351065690 292 YFF 294
Cdd:cd18052 255 YLF 257
|
|
| DEADc_DDX52 |
cd17957 |
DEAD-box helicase domain of DEAD box protein 52; DDX52 (also called ROK1 and HUSSY19) is ... |
109-280 |
2.30e-41 |
|
DEAD-box helicase domain of DEAD box protein 52; DDX52 (also called ROK1 and HUSSY19) is ubiquitously expressed in testis, endometrium, and other tissues in humans. DDX52 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350715 [Multi-domain] Cd Length: 198 Bit Score: 147.74 E-value: 2.30e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 109 IKTATPVQAACIPKILEGSDILGCARTGTGKTLAFAIPILQKL--SVDPYGIYALILTPTRELAFQIAEQFTALGKPITL 186
Cdd:cd17957 10 YREPTPIQMQAIPILLHGRDLLACAPTGSGKTLAFLIPILQKLgkPRKKKGLRALILAPTRELASQIYRELLKLSKGTGL 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 187 KCSVIVGG-RSLIHQARELSERPHVVVATPGRLADLIESDPdtiaKVFKKIQFFVLDEADRMLEGQYNDQLKPIFESISE 265
Cdd:cd17957 90 RIVLLSKSlEAKAKDGPKSITKYDILVSTPLRLVFLLKQGP----IDLSSVEYLVLDEADKLFEPGFREQTDEILAACTN 165
|
170
....*....|....*.
gi 351065690 266 KR-QTLLLSATITNNI 280
Cdd:cd17957 166 PNlQRSLFSATIPSEV 181
|
|
| DEADc_DDX6 |
cd17940 |
DEAD-box helicase domain of DEAD box protein 6; DEAD box protein 6 (DDX6, also known as Rck or ... |
113-292 |
6.16e-41 |
|
DEAD-box helicase domain of DEAD box protein 6; DEAD box protein 6 (DDX6, also known as Rck or p54) participates in mRNA regulation mediated by miRNA-mediated silencing. It also plays a role in global and transcript-specific messenger RNA (mRNA) storage, translational repression, and decay. It is a member of the DEAD-box helicase family, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350698 [Multi-domain] Cd Length: 201 Bit Score: 146.67 E-value: 6.16e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 113 TPVQAACIPKILEGSDILGCARTGTGKTLAFAIPILQKLSVDPYGIYALILTPTRELAFQIAEQFTALGKPITLKCSVIV 192
Cdd:cd17940 23 SPIQEESIPIALSGRDILARAKNGTGKTGAYLIPILEKIDPKKDVIQALILVPTRELALQTSQVCKELGKHMGVKVMVTT 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 193 GGRSLIHQARELSERPHVVVATPGRLADLIESDpdtIAKVfKKIQFFVLDEADRMLEGQYNDQLKPIFESISEKRQTLLL 272
Cdd:cd17940 103 GGTSLRDDIMRLYQTVHVLVGTPGRILDLAKKG---VADL-SHCKTLVLDEADKLLSQDFQPIIEKILNFLPKERQILLF 178
|
170 180
....*....|....*....|
gi 351065690 273 SATITNNINMLHRVSTRKPY 292
Cdd:cd17940 179 SATFPLTVKNFMDRHMHNPY 198
|
|
| DEADc_DDX5_DDX17 |
cd17966 |
DEAD-box helicase domain of ATP-dependent RNA helicases DDX5 and DDX17; DDX5 and DDX17 are ... |
113-275 |
7.38e-41 |
|
DEAD-box helicase domain of ATP-dependent RNA helicases DDX5 and DDX17; DDX5 and DDX17 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350724 [Multi-domain] Cd Length: 197 Bit Score: 146.36 E-value: 7.38e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 113 TPVQAACIPKILEGSDILGCARTGTGKTLAFAIPILQKLSVDPY-----GIYALILTPTRELAFQIAEQFTALGKPITLK 187
Cdd:cd17966 14 TAIQAQGWPMALSGRDMVGIAQTGSGKTLAFLLPAIVHINAQPPlergdGPIVLVLAPTRELAQQIQQEANKFGGSSRLR 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 188 CSVIVGGRSLIHQARELSERPHVVVATPGRLADLIESDPDTIakvfKKIQFFVLDEADRMLEGQYNDQLKPIFESISEKR 267
Cdd:cd17966 94 NTCVYGGAPKGPQIRDLRRGVEICIATPGRLIDFLDQGKTNL----RRVTYLVLDEADRMLDMGFEPQIRKIVDQIRPDR 169
|
....*...
gi 351065690 268 QTLLLSAT 275
Cdd:cd17966 170 QTLMWSAT 177
|
|
| DEADc_DDX1 |
cd17938 |
DEAD-box helicase domain of DEAD box protein 1; DEAD box protein 1 (DDX1) acts as an ... |
91-290 |
2.19e-40 |
|
DEAD-box helicase domain of DEAD box protein 1; DEAD box protein 1 (DDX1) acts as an ATP-dependent RNA helicase, able to unwind both RNA-RNA and RNA-DNA duplexes. It possesses 5' single-stranded RNA overhang nuclease activity as well as ATPase activity on various RNA, but not DNA polynucleotides. DDX1 may play a role in RNA clearance at DNA double-strand breaks (DSBs), thereby facilitating the template-guided repair of transcriptionally active regions of the genome. It may also be involved in 3'-end cleavage and polyadenylation of pre-mRNAs. DDX1 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350696 [Multi-domain] Cd Length: 204 Bit Score: 145.54 E-value: 2.19e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 91 FSQLGVCSWITQQLQTMQIKTATPVQAACIPKILEGSDILGCARTGTGKTLAFAIPILQKLSvdpygiyALILTPTRELA 170
Cdd:cd17938 1 FEELGVMPELIKAVEELDWLLPTDIQAEAIPLILGGGDVLMAAETGSGKTGAFCLPVLQIVV-------ALILEPSRELA 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 171 FQIAEQFTALGKPI---TLKCSVIVGGRSLIHQARELSERPHVVVATPGRLADLIESDPDTIAKVfkkiQFFVLDEADRM 247
Cdd:cd17938 74 EQTYNCIENFKKYLdnpKLRVALLIGGVKAREQLKRLESGVDIVVGTPGRLEDLIKTGKLDLSSV----RFFVLDEADRL 149
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 351065690 248 LEGQYNDQLKPIFESI-----SEKR-QTLLLSATitnninmLHRVSTRK 290
Cdd:cd17938 150 LSQGNLETINRIYNRIpkitsDGKRlQVIVCSAT-------LHSFEVKK 191
|
|
| DEADc_EIF4A |
cd17939 |
DEAD-box helicase domain of eukaryotic initiation factor 4A; The eukaryotic initiation ... |
116-291 |
8.05e-40 |
|
DEAD-box helicase domain of eukaryotic initiation factor 4A; The eukaryotic initiation factor-4A (eIF4A) family consists of 3 proteins EIF4A1, EIF4A2, and EIF4A3. These factors are required for the binding of mRNA to 40S ribosomal subunits. In addition these proteins are helicases that function to unwind double-stranded RNA. EIF4A proteins are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350697 [Multi-domain] Cd Length: 199 Bit Score: 143.62 E-value: 8.05e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 116 QAACIPkILEGSDILGCARTGTGKTLAFAIPILQKLSVDPYGIYALILTPTRELAFQIAEQFTALGKPITLKCSVIVGGR 195
Cdd:cd17939 25 QRAIVP-IIKGRDVIAQAQSGTGKTATFSIGALQRIDTTVRETQALVLAPTRELAQQIQKVVKALGDYMGVKVHACIGGT 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 196 SLIHQARELSERPHVVVATPGRLADLIESDpdtiAKVFKKIQFFVLDEADRMLEGQYNDQLKPIFESISEKRQTLLLSAT 275
Cdd:cd17939 104 SVREDRRKLQYGPHIVVGTPGRVFDMLQRR----SLRTDKIKMFVLDEADEMLSRGFKDQIYDIFQFLPPETQVVLFSAT 179
|
170
....*....|....*.
gi 351065690 276 ITNNINMLHRVSTRKP 291
Cdd:cd17939 180 MPHEVLEVTKKFMRDP 195
|
|
| DEADc_DDX42 |
cd17952 |
DEAD-box helicase domain of DEAD box protein 42; DDX42 (also called Splicing Factor ... |
100-285 |
9.20e-40 |
|
DEAD-box helicase domain of DEAD box protein 42; DDX42 (also called Splicing Factor 3B-Associated 125 kDa Protein, RHELP, or RNAHP) is an NTPase with a preference for ATP, the hydrolysis of which is enhanced by various RNA substrates. It acts as a non-processive RNA helicase with protein displacement and RNA annealing activities. DDX42 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350710 [Multi-domain] Cd Length: 197 Bit Score: 143.32 E-value: 9.20e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 100 ITQQLQTMQIKTATPVQAACIPKILEGSDILGCARTGTGKTLAFAIPILQKLSVDPY-----GIYALILTPTRELAFQIA 174
Cdd:cd17952 1 LLNAIRKQEYEQPTPIQAQALPVALSGRDMIGIAKTGSGKTAAFIWPMLVHIMDQRElekgeGPIAVIVAPTRELAQQIY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 175 EQFTALGKPITLKCSVIVGGRSLIHQARELSERPHVVVATPGRLADLIESDpdtiAKVFKKIQFFVLDEADRMLEGQYND 254
Cdd:cd17952 81 LEAKKFGKAYNLRVVAVYGGGSKWEQAKALQEGAEIVVATPGRLIDMVKKK----ATNLQRVTYLVLDEADRMFDMGFEY 156
|
170 180 190
....*....|....*....|....*....|.
gi 351065690 255 QLKPIFESISEKRQTLLLSATITNNINMLHR 285
Cdd:cd17952 157 QVRSIVGHVRPDRQTLLFSATFKKKIEQLAR 187
|
|
| DEADc_DDX3 |
cd18051 |
DEAD-box helicase domain of DEAD box protein 3; DDX3 (also called helicase-like protein, DEAD ... |
74-285 |
2.08e-37 |
|
DEAD-box helicase domain of DEAD box protein 3; DDX3 (also called helicase-like protein, DEAD box, X isoform, or DDX14) has been reported to display a high level of RNA-independent ATPase activity stimulated by both RNA and DNA. This protein has multiple conserved domains and is thought to play roles in both the nucleus and cytoplasm. Nuclear roles include transcriptional regulation, mRNP assembly, pre-mRNA splicing, and mRNA export. In the cytoplasm, this protein is thought to be involved in translation, cellular signaling, and viral replication. Misregulation of this gene has been implicated in tumorigenesis. Diseases associated with DDX3 include mental retardation, X-linked 102 and agenesis of the corpus callosum, with facial anomalies and robin sequence. DDX3 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350809 [Multi-domain] Cd Length: 249 Bit Score: 138.63 E-value: 2.08e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 74 DTPKPIQisednmttkKFSQLGVCSWITQQLQTMQIKTATPVQAACIPKILEGSDILGCARTGTGKTLAFAIPIL----- 148
Cdd:cd18051 15 NCPPHIE---------TFSDLDLGEIIRNNIELARYTKPTPVQKHAIPIIKSKRDLMACAQTGSGKTAAFLLPILsqiye 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 149 ---QKLSVDPYGIY--------ALILTPTRELAFQIAEQFTALGKPITLKCSVIVGGRSLIHQARELSERPHVVVATPGR 217
Cdd:cd18051 86 qgpGESLPSESGYYgrrkqyplALVLAPTRELASQIYDEARKFAYRSRVRPCVVYGGADIGQQMRDLERGCHLLVATPGR 165
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 351065690 218 LADLIESdpdtiAKV-FKKIQFFVLDEADRMLEGQYNDQLKPIFESI----SEKRQTLLLSATITNNINMLHR 285
Cdd:cd18051 166 LVDMLER-----GKIgLDYCKYLVLDEADRMLDMGFEPQIRRIVEQDtmppTGERQTLMFSATFPKEIQMLAR 233
|
|
| DEADc_EIF4AII_EIF4AI_DDX2 |
cd18046 |
DEAD-box helicase domain of eukaryotic initiation factor 4A-I and 4-II; Eukaryotic initiation ... |
116-280 |
6.90e-37 |
|
DEAD-box helicase domain of eukaryotic initiation factor 4A-I and 4-II; Eukaryotic initiation factor 4A-I (DDX2A) and eukaryotic initiation factor 4A-II (DDX2B) are involved in cap recognition and are required for mRNA binding to ribosome. They are DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350804 [Multi-domain] Cd Length: 201 Bit Score: 135.65 E-value: 6.90e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 116 QAACIPkILEGSDILGCARTGTGKTLAFAIPILQKLSVDPYGIYALILTPTRELAFQIAEQFTALGKPITLKCSVIVGGR 195
Cdd:cd18046 27 QRAIMP-CIKGYDVIAQAQSGTGKTATFSISILQQIDTSLKATQALVLAPTRELAQQIQKVVMALGDYMGIKCHACIGGT 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 196 SLIHQARELSERPHVVVATPGRLADLIES---DPDtiakvfkKIQFFVLDEADRMLEGQYNDQLKPIFESISEKRQTLLL 272
Cdd:cd18046 106 SVRDDAQKLQAGPHIVVGTPGRVFDMINRrylRTD-------YIKMFVLDEADEMLSRGFKDQIYDIFQKLPPDTQVVLL 178
|
....*...
gi 351065690 273 SATITNNI 280
Cdd:cd18046 179 SATMPNDV 186
|
|
| DEADc_DDX41 |
cd17951 |
DEAD-box helicase domain of DEAD box protein 41; DDX41 (also called ABS and MPLPF) interacts ... |
100-291 |
1.12e-36 |
|
DEAD-box helicase domain of DEAD box protein 41; DDX41 (also called ABS and MPLPF) interacts with several spliceosomal proteins and may recognize the bacterial second messengers cyclic di-GMP and cyclic di-AMP, resulting in the induction of genes involved in the innate immune response. Diseases associated with DDX41 include "myeloproliferative/lymphoproliferative neoplasms, familial" and "Ddx41-related susceptibility to familial myeloproliferative/lymphoproliferative neoplasms". DDX41 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350709 [Multi-domain] Cd Length: 206 Bit Score: 135.16 E-value: 1.12e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 100 ITQQLQTMQIKTATPVQAACIPKILEGSDILGCARTGTGKTLAFAIP-ILQKLSVD---PY----GIYALILTPTRELA- 170
Cdd:cd17951 1 ILKGLKKKGIKKPTPIQMQGLPTILSGRDMIGIAFTGSGKTLVFTLPlIMFALEQEkklPFikgeGPYGLIVCPSRELAr 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 171 --FQIAEQFTAL----GKPiTLKCSVIVGGRSLIHQARELSERPHVVVATPGRLADLIESdpdtiakvfKKI-----QFF 239
Cdd:cd17951 81 qtHEVIEYYCKAlqegGYP-QLRCLLCIGGMSVKEQLEVIRKGVHIVVATPGRLMDMLNK---------KKInldicRYL 150
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 351065690 240 VLDEADRMLEGQYNDQLKPIFESISEKRQTLLLSATITNNINMLHRVSTRKP 291
Cdd:cd17951 151 CLDEADRMIDMGFEEDIRTIFSYFKGQRQTLLFSATMPKKIQNFAKSALVKP 202
|
|
| DEADc_DDX39 |
cd17950 |
DEAD-box helicase domain of DEAD box protein 39; DDX39A is involved in pre-mRNA splicing and ... |
115-280 |
2.96e-35 |
|
DEAD-box helicase domain of DEAD box protein 39; DDX39A is involved in pre-mRNA splicing and is required for the export of mRNA out of the nucleus. DDX39B is an essential splicing factor required for association of U2 small nuclear ribonucleoprotein with pre-mRNA, and it also plays an important role in mRNA export from the nucleus to the cytoplasm. Diseases associated with DDX39A (also called UAP56-Related Helicase, 49 kDa) include gastrointestinal stromal tumor and inflammatory bowel disease 6, while diseases associated with DDX39B (also called 56 kDa U2AF65-Associated Protein) include Plasmodium vivax malaria. DDX39 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350708 [Multi-domain] Cd Length: 208 Bit Score: 131.31 E-value: 2.96e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 115 VQAACIPKILEGSDILGCARTGTGKTLAFAIPILQKLSVDPYGIYALILTPTRELAFQIAEQFTALGKPI-TLKCSVIVG 193
Cdd:cd17950 28 VQHECIPQAILGMDVLCQAKSGMGKTAVFVLSTLQQLEPVDGQVSVLVICHTRELAFQISNEYERFSKYMpNVKTAVFFG 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 194 GRSlIHQAREL--SERPHVVVATPGRLADLIESDpdtiAKVFKKIQFFVLDEADRMLEG-QYNDQLKPIFESISEKRQTL 270
Cdd:cd17950 108 GVP-IKKDIEVlkNKCPHIVVGTPGRILALVREK----KLKLSHVKHFVLDECDKMLEQlDMRRDVQEIFRATPHDKQVM 182
|
170
....*....|
gi 351065690 271 LLSATITNNI 280
Cdd:cd17950 183 MFSATLSKEI 192
|
|
| DEADc_DDX59 |
cd17962 |
DEAD-box helicase domain of DEAD box protein 59; DDX59 plays an important role in lung cancer ... |
113-283 |
8.92e-34 |
|
DEAD-box helicase domain of DEAD box protein 59; DDX59 plays an important role in lung cancer development by promoting DNA replication. DDX59 knockdown mice showed reduced cell proliferation, anchorage-independent cell growth, and reduction of tumor formation. Recent work shows that EGFR and Ras regulate DDX59 during lung cancer development. Diseases associated with DDX59 (also called zinc finger HIT domain-containing protein 5) include orofaciodigital syndrome V and orofaciodigital syndrome. DDX59 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350720 [Multi-domain] Cd Length: 193 Bit Score: 126.89 E-value: 8.92e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 113 TPVQAACIPKILEGSDILGCARTGTGKTLAFAIPILQKLSVDPYGIYALILTPTRELAFQIAEQFTALGKPI-TLKCSVI 191
Cdd:cd17962 14 TPIQMQMIPVGLLGRDILASADTGSGKTAAFLLPVIIRCLTEHRNPSALILTPTRELAVQIEDQAKELMKGLpPMKTALL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 192 VGGRSLIHQARELSERPHVVVATPGRLADLIESDPDTIAKvfkkIQFFVLDEADRMLEGQYNDQLKPIFESISEKRQTLL 271
Cdd:cd17962 94 VGGLPLPPQLYRLQQGVKVIIATPGRLLDILKQSSVELDN----IKIVVVDEADTMLKMGFQQQVLDILENISHDHQTIL 169
|
170
....*....|..
gi 351065690 272 LSATITNNINML 283
Cdd:cd17962 170 VSATIPRGIEQL 181
|
|
| DEADc_DDX17 |
cd18050 |
DEAD-box helicase domain of DEAD box protein 17; DDX17 (also called DEAD Box Protein P72 or ... |
76-283 |
1.22e-32 |
|
DEAD-box helicase domain of DEAD box protein 17; DDX17 (also called DEAD Box Protein P72 or DEAD Box Protein P82) has a wide variety of functions including regulating the alternative splicing of exons exhibiting specific features such as the inclusion of AC-rich alternative exons in CD44 transcripts, playing a role in innate immunity, and promoting mRNA degradation mediated by the antiviral zinc-finger protein ZC3HAV1 in an ATPase-dependent manner. DDX17 synergizes with DDX5 and SRA1 RNA to activate MYOD1 transcriptional activity and is involved in skeletal muscle differentiation. DDX17 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350808 [Multi-domain] Cd Length: 271 Bit Score: 126.28 E-value: 1.22e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 76 PKPIQisednmttkKFSQLGVCSWITQQLQTMQIKTATPVQAACIPKILEGSDILGCARTGTGKTLAFAIPILQKLSVDP 155
Cdd:cd18050 58 PKPVF---------AFHQANFPQYVMDVLLDQNFKEPTPIQCQGFPLALSGRDMVGIAQTGSGKTLAYLLPAIVHINHQP 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 156 Y-----GIYALILTPTRELAFQIAEQFTALGKPITLKCSVIVGGRSLIHQARELSERPHVVVATPGRLADLIESDPDTIa 230
Cdd:cd18050 129 YlergdGPICLVLAPTRELAQQVQQVADDYGKSSRLKSTCIYGGAPKGPQIRDLERGVEICIATPGRLIDFLEAGKTNL- 207
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 351065690 231 kvfKKIQFFVLDEADRMLEGQYNDQLKPIFESISEKRQTLLLSATITNNINML 283
Cdd:cd18050 208 ---RRCTYLVLDEADRMLDMGFEPQIRKIVDQIRPDRQTLMWSATWPKEVRQL 257
|
|
| DEADc_DDX5 |
cd18049 |
DEAD-box helicase domain of DEAD box protein 5; DDX5 (also called RNA helicase P68, HLR1, ... |
74-283 |
4.94e-32 |
|
DEAD-box helicase domain of DEAD box protein 5; DDX5 (also called RNA helicase P68, HLR1, G17P1, or HUMP68) is involved in pathways that include the alteration of RNA structures, plays a role as a coregulator of transcription, a regulator of splicing, and in the processing of small noncoding RNAs. It synergizes with DDX17 and SRA1 RNA to activate MYOD1 transcriptional activity and is involved in skeletal muscle differentiation. Dysregulation of this gene may play a role in cancer development. DDX5 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350807 [Multi-domain] Cd Length: 234 Bit Score: 123.58 E-value: 4.94e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 74 DTPKPIQisednmttkKFSQLGVCSWITQQLQTMQIKTATPVQAACIPKILEGSDILGCARTGTGKTLAFAIPILQKLSV 153
Cdd:cd18049 18 NCPKPVL---------NFYEANFPANVMDVIARQNFTEPTAIQAQGWPVALSGLDMVGVAQTGSGKTLSYLLPAIVHINH 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 154 DPY-----GIYALILTPTRELAFQIAEQFTALGKPITLKCSVIVGGRSLIHQARELSERPHVVVATPGRLADLIESDPDT 228
Cdd:cd18049 89 QPFlergdGPICLVLAPTRELAQQVQQVAAEYGRACRLKSTCIYGGAPKGPQIRDLERGVEICIATPGRLIDFLEAGKTN 168
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 351065690 229 IakvfKKIQFFVLDEADRMLEGQYNDQLKPIFESISEKRQTLLLSATITNNINML 283
Cdd:cd18049 169 L----RRCTYLVLDEADRMLDMGFEPQIRKIVDQIRPDRQTLMWSATWPKEVRQL 219
|
|
| DEADc_DDX43_DDX53 |
cd17958 |
DEAD-box helicase domain of DEAD box proteins 43 and 53; DDX43 (also called cancer/testis ... |
100-275 |
1.96e-30 |
|
DEAD-box helicase domain of DEAD box proteins 43 and 53; DDX43 (also called cancer/testis antigen 13 or helical antigen) displays tumor-specific expression. Diseases associated with DDX43 include rheumatoid lung disease. DDX53 is also called cancer/testis antigen 26 or DEAD-Box Protein CAGE. Both DDX46 and DDX53 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350716 [Multi-domain] Cd Length: 197 Bit Score: 117.95 E-value: 1.96e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 100 ITQQLQTMQIKTATPVQAACIPKILEGSDILGCARTGTGKTLAFAIPILQKLSVDPY------GIYALILTPTRELAFQI 173
Cdd:cd17958 1 IMKEIKKQGFEKPSPIQSQAWPIILQGIDLIGVAQTGTGKTLAYLLPGFIHLDLQPIpreqrnGPGVLVLTPTRELALQI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 174 AEQFTALgKPITLKCSVIVGGRSLIHQARELSERPHVVVATPGRLADLIESDpdtiAKVFKKIQFFVLDEADRMLEGQYN 253
Cdd:cd17958 81 EAECSKY-SYKGLKSVCVYGGGNRNEQIEDLSKGVDIIIATPGRLNDLQMNN----VINLKSITYLVLDEADRMLDMGFE 155
|
170 180
....*....|....*....|..
gi 351065690 254 DQLKPIFESISEKRQTLLLSAT 275
Cdd:cd17958 156 PQIRKILLDIRPDRQTIMTSAT 177
|
|
| Helicase_C |
pfam00271 |
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ... |
327-432 |
1.69e-29 |
|
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.
Pssm-ID: 459740 [Multi-domain] Cd Length: 109 Bit Score: 111.92 E-value: 1.69e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 327 VVKNYSEKNPKSSVMIFAQTCRECQAlAYMFEGLGFRVGSLHSQIPQKQRLAALSAFRSKTLQVIICTDVASRGLDIPHV 406
Cdd:pfam00271 5 ALLELLKKERGGKVLIFSQTKKTLEA-ELLLEKEGIKVARLHGDLSQEEREEILEDFRKGKIDVLVATDVAERGLDLPDV 83
|
90 100
....*....|....*....|....*.
gi 351065690 407 DLVVNHNVPQCPKTYIHRVGRSARAG 432
Cdd:pfam00271 84 DLVINYDLPWNPASYIQRIGRAGRAG 109
|
|
| DEADc_DDX28 |
cd17948 |
DEAD-box helicase domain of DEAD box protein 28; DDX28 (also called mitochondrial DEAD-box ... |
100-286 |
2.38e-28 |
|
DEAD-box helicase domain of DEAD box protein 28; DDX28 (also called mitochondrial DEAD-box polypeptide 28) plays an essential role in facilitating the proper assembly of the mitochondrial large ribosomal subunit and its helicase activity is essential for this function. DDX28 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350706 [Multi-domain] Cd Length: 231 Bit Score: 112.85 E-value: 2.38e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 100 ITQQLQTMQIKTATPVQAACIPKILEGSDILGCARTGTGKTLAFAIPILQKLSVDPY-------GIYALILTPTRELAFQ 172
Cdd:cd17948 1 LVEILQRQGITKPTTVQKQGIPSILRGRNTLCAAETGSGKTLTYLLPIIQRLLRYKLlaegpfnAPRGLVITPSRELAEQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 173 IAEQFTALGKPITLKCSVIVGGRS-----LIHQarelsERPHVVVATPGRLADLIESDpdtIAKVfKKIQFFVLDEADRM 247
Cdd:cd17948 81 IGSVAQSLTEGLGLKVKVITGGRTkrqirNPHF-----EEVDILVATPGALSKLLTSR---IYSL-EQLRHLVLDEADTL 151
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 351065690 248 LEGQYNDQL-------------KPIFESISEKRQTLLLSATITNNIN-MLHRV 286
Cdd:cd17948 152 LDDSFNEKLshflrrfplasrrSENTDGLDPGTQLVLVSATMPSGVGeVLSKV 204
|
|
| DEADc_EIF4AIII_DDX48 |
cd18045 |
DEAD-box helicase domain of eukaryotic initiation factor 4A-III; Eukaryotic initiation factor ... |
110-280 |
1.69e-27 |
|
DEAD-box helicase domain of eukaryotic initiation factor 4A-III; Eukaryotic initiation factor 4A-III (EIF4AIII, also known as DDX48) is part of the exon junction complex (EJC) that plays a major role in posttranscriptional regulation of mRNA. EJC consists of four proteins (eIF4AIII, Barentsz [Btz], Mago, and Y14), mRNA, and ATP. DDX48 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350803 [Multi-domain] Cd Length: 201 Bit Score: 109.86 E-value: 1.69e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 110 KTATPVQAACIPKILEGSDILGCARTGTGKTLAFAIPILQKLSVDPYGIYALILTPTRELAFQIAEQFTALGKPITLKCS 189
Cdd:cd18045 20 EKPSAIQQRAIKPIIKGRDVIAQSQSGTGKTATFSISVLQCLDIQVRETQALILSPTRELAVQIQKVLLALGDYMNVQCH 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 190 VIVGGRSLIHQARELSERPHVVVATPGRLADLIESDpdtiAKVFKKIQFFVLDEADRMLEGQYNDQLKPIFESISEKRQT 269
Cdd:cd18045 100 ACIGGTSVGDDIRKLDYGQHIVSGTPGRVFDMIRRR----SLRTRHIKMLVLDEADEMLNKGFKEQIYDVYRYLPPATQV 175
|
170
....*....|.
gi 351065690 270 LLLSATITNNI 280
Cdd:cd18045 176 VLVSATLPQDI 186
|
|
| HELICc |
smart00490 |
helicase superfamily c-terminal domain; |
351-432 |
3.23e-25 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 99.21 E-value: 3.23e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 351 QALAYMFEGLGFRVGSLHSQIPQKQRLAALSAFRSKTLQVIICTDVASRGLDIPHVDLVVNHNVPQCPKTYIHRVGRSAR 430
Cdd:smart00490 1 EELAELLKELGIKVARLHGGLSQEEREEILDKFNNGKIKVLVATDVAERGLDLPGVDLVIIYDLPWSPASYIQRIGRAGR 80
|
..
gi 351065690 431 AG 432
Cdd:smart00490 81 AG 82
|
|
| DEADc_DDX21_DDX50 |
cd17944 |
DEAD-box helicase domain of DEAD box proteins 21 and 50; DDX21 (also called Gu-Alpha and ... |
102-275 |
3.69e-25 |
|
DEAD-box helicase domain of DEAD box proteins 21 and 50; DDX21 (also called Gu-Alpha and nucleolar RNA helicase 2) is an RNA helicase that acts as a sensor of the transcriptional status of both RNA polymerase (Pol) I and II. It promotes ribosomal RNA (rRNA) processing and transcription from polymerase II (Pol II) and binds various RNAs, such as rRNAs, snoRNAs, 7SK and, at lower extent, mRNAs. DDX50 (also called Gu-Beta, Nucleolar Protein Gu2, and malignant cell derived RNA helicase). DDX21 and DDX50 have similar genomic structures and are in tandem orientation on chromosome 10, suggesting that the two genes arose by gene duplication in evolution. Diseases associated with DDX21 include stomach disease and cerebral creatine deficiency syndrome 3. Diseases associated with DDX50 include rectal disease. Both are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. Their name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP- binding region.
Pssm-ID: 350702 [Multi-domain] Cd Length: 202 Bit Score: 103.00 E-value: 3.69e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 102 QQLQTMQIKTATPVQAACIPKILEGSDILGCARTGTGKTLAFAIPILQKLSVDPYGI------YALILTPTRELAFQIAE 175
Cdd:cd17944 3 KLLQARGVTYLFPIQVKTFHPVYSGKDLIAQARTGTGKTFSFAIPLIEKLQEDQQPRkrgrapKVLVLAPTRELANQVTK 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 176 QFTALGKPITLKCsvIVGGRSLIHQARELSERPHVVVATPGRLADLIESDPDTIAKVfkkiQFFVLDEADRMLEGQYNDQ 255
Cdd:cd17944 83 DFKDITRKLSVAC--FYGGTPYQQQIFAIRNGIDILVGTPGRIKDHLQNGRLDLTKL----KHVVLDEVDQMLDMGFAEQ 156
|
170 180
....*....|....*....|....*
gi 351065690 256 LKPI----FESISEKR-QTLLLSAT 275
Cdd:cd17944 157 VEEIlsvsYKKDSEDNpQTLLFSAT 181
|
|
| DEADc_DDX19_DDX25 |
cd17963 |
DEAD-box helicase domain of ATP-dependent RNA helicases DDX19 and DDX25; DDX19 (also called ... |
104-275 |
9.01e-25 |
|
DEAD-box helicase domain of ATP-dependent RNA helicases DDX19 and DDX25; DDX19 (also called DEAD box RNA helicase DEAD5) and DDX25 (also called gonadotropin-regulated testicular RNA helicase (GRTH)) are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350721 [Multi-domain] Cd Length: 196 Bit Score: 101.88 E-value: 9.01e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 104 LQTMQIKTATPVQAACIPKILEG--SDILGCARTGTGKTLAFAIPILQKlsVDPYGIY--ALILTPTRELAFQIAEQFTA 179
Cdd:cd17963 9 LYAMGFNKPSKIQETALPLILSDppENLIAQSQSGTGKTAAFVLAMLSR--VDPTLKSpqALCLAPTRELARQIGEVVEK 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 180 LGKPITLKCSVIVGGRSlIHQARELSErpHVVVATPGRLADLIES---DPdtiakvfKKIQFFVLDEADRMLEGQ-YNDQ 255
Cdd:cd17963 87 MGKFTGVKVALAVPGND-VPRGKKITA--QIVIGTPGTVLDWLKKrqlDL-------KKIKILVLDEADVMLDTQgHGDQ 156
|
170 180
....*....|....*....|
gi 351065690 256 LKPIFESISEKRQTLLLSAT 275
Cdd:cd17963 157 SIRIKRMLPRNCQILLFSAT 176
|
|
| SSL2 |
COG1061 |
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair]; |
135-560 |
2.11e-23 |
|
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
Pssm-ID: 440681 [Multi-domain] Cd Length: 566 Bit Score: 103.95 E-value: 2.11e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 135 TGTGKTLAFAIPILQKLSVDPygiyALILTPTRELAFQIAEQFTALgkpitLKCSVIVGGRSlihqarelSERPHVVVAT 214
Cdd:COG1061 109 TGTGKTVLALALAAELLRGKR----VLVLVPRRELLEQWAEELRRF-----LGDPLAGGGKK--------DSDAPITVAT 171
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 215 PGRLA-----DLIESDPDTIakvfkkiqffVLDEADRMLEGQYNDqlkpIFESISEKRqTLLLSAT----------ITNN 279
Cdd:COG1061 172 YQSLArrahlDELGDRFGLV----------IIDEAHHAGAPSYRR----ILEAFPAAY-RLGLTATpfrsdgreilLFLF 236
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 280 INMLHRVSTR--------KPYFF-------EDKGKDDESTVDRLEQKYVVCPVAVKDaylvyVVKNYSEKNPKSS-VMIF 343
Cdd:COG1061 237 DGIVYEYSLKeaiedgylAPPEYygirvdlTDERAEYDALSERLREALAADAERKDK-----ILRELLREHPDDRkTLVF 311
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 344 AQTCRECQALAYMFEGLGFRVGSLHSQIPQKQRLAALSAFRSKTLQVIICTDVASRGLDIPHVDLVVNHNVPQCPKTYIH 423
Cdd:COG1061 312 CSSVDHAEALAELLNEAGIRAAVVTGDTPKKEREEILEAFRDGELRILVTVDVLNEGVDVPRLDVAILLRPTGSPREFIQ 391
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 424 RVGR---SARAGRFGSALSFVTQyDVELLQAveqvIGKKLDELKVSPKHVTKYVTQVLVAKKEAELKLENQKFGEKKEIN 500
Cdd:COG1061 392 RLGRglrPAPGKEDALVYDFVGN-DVPVLEE----LAKDLRDLAGYRVEFLDEEESEELALLIAVKPALEVKGELEEELL 466
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 501 RRKELLmsgmDEDEADRHLEEMRTRRMTNSKRKLEKISGQLDKRDRFQKKLAAKKVKKEE 560
Cdd:COG1061 467 EELELL----EDALLLVLAELLLLELLALALELLELAKAEGKAEEEEEEKELLLLLALAK 522
|
|
| DEADc_MRH4 |
cd17965 |
DEAD-box helicase domain of ATP-dependent RNA helicase MRH4; Mitochondrial RNA helicase 4 ... |
105-276 |
2.97e-19 |
|
DEAD-box helicase domain of ATP-dependent RNA helicase MRH4; Mitochondrial RNA helicase 4 (MRH4) plays an essential role during the late stages of mitochondrial ribosome or mitoribosome assembly by promoting remodeling of the 21S rRNA-protein interactions. MRH4 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350723 [Multi-domain] Cd Length: 251 Bit Score: 87.43 E-value: 2.97e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 105 QTMQIKtATPVQAACIPKILEGSDI----------------LGCARTGTGKTLAFAIPILQKLS---------------- 152
Cdd:cd17965 25 TDEEIK-PSPIQTLAIKKLLKTLMRkvtkqtsneepklevfLLAAETGSGKTLAYLAPLLDYLKrqeqepfeeaeeeyes 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 153 -VDPYGIYALILTPTRELAFQIAEQFTALGKPITLKCSVIVGGRSLIHQAREL--SERPHVVVATPGRLADLIESDPdti 229
Cdd:cd17965 104 aKDTGRPRSVILVPTHELVEQVYSVLKKLSHTVKLGIKTFSSGFGPSYQRLQLafKGRIDILVTTPGKLASLAKSRP--- 180
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 351065690 230 aKVFKKIQFFVLDEADRMLEGQYNDQLKPIFESISEKRQTLLLSATI 276
Cdd:cd17965 181 -KILSRVTHLVVDEADTLFDRSFLQDTTSIIKRAPKLKHLILCSATI 226
|
|
| SF2-N |
cd00046 |
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ... |
126-275 |
3.29e-17 |
|
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.
Pssm-ID: 350668 [Multi-domain] Cd Length: 146 Bit Score: 78.60 E-value: 3.29e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 126 GSDILGCARTGTGKTLAFAIPILQKLsvDPYGIYALILTPTRELAFQIAEQFTALGKPiTLKCSVIVGGRSLIHQARELS 205
Cdd:cd00046 1 GENVLITAPTGSGKTLAALLAALLLL--LKKGKKVLVLVPTKALALQTAERLRELFGP-GIRVAVLVGGSSAEEREKNKL 77
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 351065690 206 ERPHVVVATPGRLADLIESDpdtIAKVFKKIQFFVLDEADRMLegqYNDQLKPIFESISEKR-----QTLLLSAT 275
Cdd:cd00046 78 GDADIIIATPDMLLNLLLRE---DRLFLKDLKLIIVDEAHALL---IDSRGALILDLAVRKAglknaQVILLSAT 146
|
|
| DEADc_DDX19 |
cd18047 |
DEAD-box helicase domain of DEAD box protein 19; DDX19 is an RNA helicase involved in both ... |
89-280 |
6.58e-12 |
|
DEAD-box helicase domain of DEAD box protein 19; DDX19 is an RNA helicase involved in both mRNA (mRNA) export from the nucleus into the cytoplasm and in mRNA translation. DDX19 functions in the nucleus in resolving RNA:DNA hybrids (R-loops). Activation of a DNA damage response pathway dependent upon the ATR kinase, a major regulator of replication fork progression, stimulates translocation of DDX19 from the cytoplasm into the nucleus. Only nuclear Ddx19 is competent to resolve R-loops. DDX19 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350805 [Multi-domain] Cd Length: 205 Bit Score: 65.13 E-value: 6.58e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 89 KKFSQLGVCSWITQQLQTMQIKTATPVQAACIPKILEG--SDILGCARTGTGKTLAFAIPILQKlsVDPYGIYA--LILT 164
Cdd:cd18047 1 KSFEELRLKPQLLQGVYAMGFNRPSKIQENALPLMLAEppQNLIAQSQSGTGKTAAFVLAMLSQ--VEPANKYPqcLCLS 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 165 PTRELAFQIAEQFTALGK--PITLKCSVIVGGRslihQARELSERPHVVVATPGRLAD----LIESDPdtiakvfKKIQF 238
Cdd:cd18047 79 PTYELALQTGKVIEQMGKfyPELKLAYAVRGNK----LERGQKISEQIVIGTPGTVLDwcskLKFIDP-------KKIKV 147
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 351065690 239 FVLDEADRMLEGQ-YNDQLKPIFESISEKRQTLLLSATITNNI 280
Cdd:cd18047 148 FVLDEADVMIATQgHQDQSIRIQRMLPRNCQMLLFSATFEDSV 190
|
|
| MPH1 |
COG1111 |
ERCC4-related helicase [Replication, recombination and repair]; |
320-432 |
9.04e-12 |
|
ERCC4-related helicase [Replication, recombination and repair];
Pssm-ID: 440728 [Multi-domain] Cd Length: 718 Bit Score: 67.83 E-value: 9.04e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 320 KDAYLVYVVKNYSEKNPKSSVMIFAQTCRECQALAYMFEGLGFRVGSLHSQ--------IPQKQRLAALSAFRSKTLQVI 391
Cdd:COG1111 336 KLSKLREILKEQLGTNPDSRIIVFTQYRDTAEMIVEFLSEPGIKAGRFVGQaskegdkgLTQKEQIEILERFRAGEFNVL 415
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 351065690 392 ICTDVASRGLDIPHVDLVVNH-NVPQcPKTYIHRVGRSARAG 432
Cdd:COG1111 416 VATSVAEEGLDIPEVDLVIFYePVPS-EIRSIQRKGRTGRKR 456
|
|
| DEADc_DDX25 |
cd18048 |
DEAD-box helicase domain of DEAD box protein 25; DDX25 (also called gonadotropin-regulated ... |
87-280 |
1.16e-11 |
|
DEAD-box helicase domain of DEAD box protein 25; DDX25 (also called gonadotropin-regulated testicular RNA helicase (GRTH) is a testis-specific protein essential for completion of spermatogenesis. DDX25 is also a novel negative regulator of IFN pathway and facilitates RNA virus infection. Diseases associated with DDX25 include hydrolethalus syndrome, an autosomal recessive lethal malformation syndrome characterized by multiple developmental defects of fetus.. DDX25 (also called gonadotropin-regulated testicular RNA helicase) is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350806 [Multi-domain] Cd Length: 229 Bit Score: 64.66 E-value: 1.16e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 87 TTKKFSQLGVCSWITQQLQTMQIKTATPVQAACIPKILEG--SDILGCARTGTGKTLAFAIPILQKLSVDPYGIYALILT 164
Cdd:cd18048 16 SVKSFEELHLKEELLRGIYAMGFNRPSKIQENALPMMLADppQNLIAQSQSGTGKTAAFVLAMLSRVDALKLYPQCLCLS 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 165 PTRELAFQIAEQFTALGKpitlkcsvIVGGRSLIHQARelSERP--------HVVVATPGRLAD------LIEsdpdtia 230
Cdd:cd18048 96 PTFELALQTGKVVEEMGK--------FCVGIQVIYAIR--GNRPgkgtdieaQIVIGTPGTVLDwcfklrLID------- 158
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 351065690 231 kvFKKIQFFVLDEADRMLEGQ-YNDQLKPIFESISEKRQTLLLSATITNNI 280
Cdd:cd18048 159 --VTNISVFVLDEADVMINVQgHSDHSVRVKRSMPKECQMLLFSATFEDSV 207
|
|
| DEXHc_Ski2 |
cd17921 |
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases ... |
113-278 |
2.06e-11 |
|
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases play an important role in RNA degradation, processing, and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350679 [Multi-domain] Cd Length: 181 Bit Score: 63.05 E-value: 2.06e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 113 TPVQAACIPKI-LEGSDILGCARTGTGKTLAFAIPILQKLSVdpYGIYALILTPTRELAFQIAEQFTALGKPITLKCSVI 191
Cdd:cd17921 3 NPIQREALRALyLSGDSVLVSAPTSSGKTLIAELAILRALAT--SGGKAVYIAPTRALVNQKEADLRERFGPLGKNVGLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 192 VGGRSLihqARELSERPHVVVATPGRLADLIESDPDTIakvFKKIQFFVLDEADRMLEGQYNDQLKPIFESI---SEKRQ 268
Cdd:cd17921 81 TGDPSV---NKLLLAEADILVATPEKLDLLLRNGGERL---IQDVRLVVVDEAHLIGDGERGVVLELLLSRLlriNKNAR 154
|
170
....*....|
gi 351065690 269 TLLLSATITN 278
Cdd:cd17921 155 FVGLSATLPN 164
|
|
| YprA |
COG1205 |
ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, ... |
116-433 |
5.15e-11 |
|
ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, recombination and repair];
Pssm-ID: 440818 [Multi-domain] Cd Length: 758 Bit Score: 65.63 E-value: 5.15e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 116 QAACIPKILEGSDILGCARTGTGKTLAFAIPILQKLSVDPyGIYALILTPTRELAF-QIAEqFTALGKPITLKCSV-IVG 193
Cdd:COG1205 61 QAEAIEAARAGKNVVIATPTASGKSLAYLLPVLEALLEDP-GATALYLYPTKALARdQLRR-LRELAEALGLGVRVaTYD 138
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 194 GRSLIHQARELSERPHVVVATPgrlaDLIES----DPDTIAKVFKKIQFFVLDEA---------------DRMLE--GQY 252
Cdd:COG1205 139 GDTPPEERRWIREHPDIVLTNP----DMLHYgllpHHTRWARFFRNLRYVVIDEAhtyrgvfgshvanvlRRLRRicRHY 214
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 253 NDqlKPIFesisekrqtLLLSATITNNINMLHRVStrkpyffedkGKD----DESTVDRLEQKYV------VCPVAVKDA 322
Cdd:COG1205 215 GS--DPQF---------ILASATIGNPAEHAERLT----------GRPvtvvDEDGSPRGERTFVlwnpplVDDGIRRSA 273
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 323 YL--VYVVKNYSEKNPKssVMIFAQT----------CREcqalAYMFEGLGFRVGSLHSQIPQKQRLAALSAFRSKTLQV 390
Cdd:COG1205 274 LAeaARLLADLVREGLR--TLVFTRSrrgaellaryARR----ALREPDLADRVAAYRAGYLPEERREIERGLRSGELLG 347
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 351065690 391 IICTDVASRGLDIPHVDLVVNHNVPQCPKTYIHRVGRSARAGR 433
Cdd:COG1205 348 VVSTNALELGIDIGGLDAVVLAGYPGTRASFWQQAGRAGRRGQ 390
|
|
| DEXHc_Hrq1-like |
cd17923 |
DEAH-box helicase domain of Hrq1 and similar proteins; Yeast Hrq1, similar to RecQ4, plays a ... |
116-278 |
3.34e-10 |
|
DEAH-box helicase domain of Hrq1 and similar proteins; Yeast Hrq1, similar to RecQ4, plays a role in DNA inter-strand crosslink (ICL) repair and in telomere maintenance. Hrq1 lacks the Sld2-like domain found in RecQ4. Hrq1 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350681 [Multi-domain] Cd Length: 182 Bit Score: 59.52 E-value: 3.34e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 116 QAACIPKILEGSDILGCARTGTGKTLAFAIPILQKLSVDPyGIYALILTPTRELAFQIAEQFTALGKPITLK--CSVIVG 193
Cdd:cd17923 5 QAEAIEAARAGRSVVVTTGTASGKSLCYQLPILEALLRDP-GSRALYLYPTKALAQDQLRSLRELLEQLGLGirVATYDG 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 194 GRSLIHQARELSERPHVVVATPGRLADLIESDPDTIAKVFKKIQFFVLDEAdRMLEGQYNDQ-------LKPIFESISEK 266
Cdd:cd17923 84 DTPREERRAIIRNPPRILLTNPDMLHYALLPHHDRWARFLRNLRYVVLDEA-HTYRGVFGSHvalllrrLRRLCRRYGAD 162
|
170
....*....|..
gi 351065690 267 RQTLLLSATITN 278
Cdd:cd17923 163 PQFILTSATIGN 174
|
|
| SF2_C_dicer |
cd18802 |
C-terminal helicase domain of the endoribonuclease Dicer; Dicer ribonucleases cleave ... |
324-431 |
8.21e-10 |
|
C-terminal helicase domain of the endoribonuclease Dicer; Dicer ribonucleases cleave double-stranded RNA (dsRNA) precursors to generate microRNAs (miRNAs) and small interfering RNAs (siRNAs). In concert with Argonautes, these small RNAs bind complementary mRNAs to down-regulate their expression. miRNAs are processed by Dicer from small hairpins, while siRNAs are typically processed from longer dsRNA, from endogenous sources, or exogenous sources such as viral replication intermediates. Some organisms, such as Homo sapiens and Caenorhabditis elegans, encode one Dicer that generates miRNAs and siRNAs, but other organisms have multiple dicers with specialized functions. Dicer exists throughout eukaryotes, and a subset has an N-terminal helicase domain of the RIG-I-like receptor (RLR) subgroup. RLRs often function in innate immunity and Dicer helicase domains sometimes show differences in activity that correlate with roles in immunity. Dicer helicase domains are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350189 [Multi-domain] Cd Length: 142 Bit Score: 57.22 E-value: 8.21e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 324 LVYVVKNYSEKNPKSSVMIFAQTCRECQALAYMFE---------------GLGFRVGSLHSQIPQKQRLAALSAFRSKTL 388
Cdd:cd18802 12 LIEILREYFPKTPDFRGIIFVERRATAVVLSRLLKehpstlafircgfliGRGNSSQRKRSLMTQRKQKETLDKFRDGEL 91
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 351065690 389 QVIICTDVASRGLDIPHVDLVVNHNVPQCPKTYIHRVGRsARA 431
Cdd:cd18802 92 NLLIATSVLEEGIDVPACNLVIRFDLPKTLRSYIQSRGR-ARA 133
|
|
| DEXHc_archSki2 |
cd18028 |
DEXH-box helicase domain of archaeal Ski2-type helicase; Archaeal Ski2-type RNA helicases play ... |
114-278 |
5.03e-09 |
|
DEXH-box helicase domain of archaeal Ski2-type helicase; Archaeal Ski2-type RNA helicases play an important role in RNA degradation, processing and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350786 [Multi-domain] Cd Length: 177 Bit Score: 55.80 E-value: 5.03e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 114 PVQAACIPK-ILEGSDILGCARTGTGKTLAFAIPILQKLSVDPYGIYaliLTPTRELAFQIAEQFTALgKPITLKCSVIV 192
Cdd:cd18028 4 PPQAEAVRAgLLKGENLLISIPTASGKTLIAEMAMVNTLLEGGKALY---LVPLRALASEKYEEFKKL-EEIGLKVGIST 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 193 GgrSLIHQARELSERpHVVVATPGRLADLIESDPDTIakvfKKIQFFVLDE---ADRMLEGqyndqlkPIFESISEK--- 266
Cdd:cd18028 80 G--DYDEDDEWLGDY-DIIVATYEKFDSLLRHSPSWL----RDVGVVVVDEihlISDEERG-------PTLESIVARlrr 145
|
170
....*....|....*.
gi 351065690 267 ----RQTLLLSATITN 278
Cdd:cd18028 146 lnpnTQIIGLSATIGN 161
|
|
| DEXHc_LHR-like |
cd17922 |
DEXH-box helicase domain of LHR; Large helicase-related protein (LHR) is a DNA ... |
126-278 |
8.09e-09 |
|
DEXH-box helicase domain of LHR; Large helicase-related protein (LHR) is a DNA damage-inducible helicase that uses ATP hydrolysis to drive unidirectional 3'-to-5' translocation along single-stranded DNA (ssDNA) and to unwind RNA:DNA duplexes. This group also includes related bacterial and archaeal helicases from the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350680 [Multi-domain] Cd Length: 166 Bit Score: 54.90 E-value: 8.09e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 126 GSDILGCARTGTGKTLAFAIPILQKLSVDPY-GIYALILTPTRELafqIAEQFTALGKPIT-LKCSVIVGGRsliH---- 199
Cdd:cd17922 1 GRNVLIAAPTGSGKTEAAFLPALSSLADEPEkGVQVLYISPLKAL---INDQERRLEEPLDeIDLEIPVAVR---Hgdts 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 200 ---QARELSERPHVVVATPGRLADLIESDPdtIAKVFKKIQFFVLDEADRMLEGQYNDQLKPIFESISE----KRQTLLL 272
Cdd:cd17922 75 qseKAKQLKNPPGILITTPESLELLLVNKK--LRELFAGLRYVVVDEIHALLGSKRGVQLELLLERLRKltgrPLRRIGL 152
|
....*.
gi 351065690 273 SATITN 278
Cdd:cd17922 153 SATLGN 158
|
|
| SF2_C |
cd18785 |
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases ... |
388-436 |
2.06e-07 |
|
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases include DEAD-box helicases, UvrB, RecG, Ski2, Sucrose Non-Fermenting (SNF) family helicases, and dicer proteins, among others. Similar to SF1 helicases, they do not form toroidal structures like SF3-6 helicases. SF2 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350172 [Multi-domain] Cd Length: 77 Bit Score: 48.47 E-value: 2.06e-07
10 20 30 40
....*....|....*....|....*....|....*....|....*....
gi 351065690 388 LQVIICTDVASRGLDIPHVDLVVNHNVPQCPKTYIHRVGRSARAGRFGS 436
Cdd:cd18785 23 LEILVATNVLGEGIDVPSLDTVIFFDPPSSAASYIQRVGRAGRGGKDEG 71
|
|
| PRK13767 |
PRK13767 |
ATP-dependent helicase; Provisional |
110-428 |
3.79e-07 |
|
ATP-dependent helicase; Provisional
Pssm-ID: 237497 [Multi-domain] Cd Length: 876 Bit Score: 52.97 E-value: 3.79e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 110 KTATPVQAACIPKILEGSDILGCARTGTGKTLAFAIPILQKLSVDPY------GIYALILTPTRELA-----------FQ 172
Cdd:PRK13767 31 GTFTPPQRYAIPLIHEGKNVLISSPTGSGKTLAAFLAIIDELFRLGRegeledKVYCLYVSPLRALNndihrnleeplTE 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 173 IAEQFTALGKPIT-LKCSVIVGGRSLIHQARELSERPHVVVATPGRLADLIESdPDtiakvFKK----IQFFVLDEADRM 247
Cdd:PRK13767 111 IREIAKERGEELPeIRVAIRTGDTSSYEKQKMLKKPPHILITTPESLAILLNS-PK-----FREklrtVKWVIVDEIHSL 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 248 LEGQYNDQLkpifeSISEKRQTLL---------LSATitnnINMLHRVSTrkpyF---FEDKGKD-DESTVD-RLEQKY- 312
Cdd:PRK13767 185 AENKRGVHL-----SLSLERLEELaggefvrigLSAT----IEPLEEVAK----FlvgYEDDGEPrDCEIVDaRFVKPFd 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 313 --VVCPvaVKDayLVY------------VVKNYSEKNpkSSVMIFAQTCRECQALAY----MFEGLG--FRVGSLHSQIP 372
Cdd:PRK13767 252 ikVISP--VDD--LIHtpaeeisealyeTLHELIKEH--RTTLIFTNTRSGAERVLYnlrkRFPEEYdeDNIGAHHSSLS 325
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 351065690 373 QKQRLAALSAFRSKTLQVIICTDVASRGLDIPHVDLVVNHNVPQCPKTYIHRVGRS 428
Cdd:PRK13767 326 REVRLEVEEKLKRGELKVVVSSTSLELGIDIGYIDLVVLLGSPKSVSRLLQRIGRA 381
|
|
| PRK13766 |
PRK13766 |
Hef nuclease; Provisional |
324-433 |
1.03e-06 |
|
Hef nuclease; Provisional
Pssm-ID: 237496 [Multi-domain] Cd Length: 773 Bit Score: 51.80 E-value: 1.03e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 324 LVYVVKNYSEKNPKSSVMIFAQTCRECQALAYMFEGLGFRVGSLHSQ--------IPQKQRLAALSAFRSKTLQVIICTD 395
Cdd:PRK13766 352 LREIVKEQLGKNPDSRIIVFTQYRDTAEKIVDLLEKEGIKAVRFVGQaskdgdkgMSQKEQIEILDKFRAGEFNVLVSTS 431
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 351065690 396 VASRGLDIPHVDLVVNHN-VPQCPKTyIHRVGRSAR--AGR 433
Cdd:PRK13766 432 VAEEGLDIPSVDLVIFYEpVPSEIRS-IQRKGRTGRqeEGR 471
|
|
| SF2_C_FANCM_Hef |
cd18801 |
C-terminal helicase domain of Fanconi anemia group M family helicases; Fanconi anemia group M ... |
373-430 |
1.56e-06 |
|
C-terminal helicase domain of Fanconi anemia group M family helicases; Fanconi anemia group M (FANCM) protein is a DNA-dependent ATPase component of the Fanconi anemia (FA) core complex. It is required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. Hef (helicase-associated endonuclease fork-structure) belongs to the XPF/MUS81/FANCM family of endonucleases and is involved in stalled replication fork repair. FANCM and Hef are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350188 [Multi-domain] Cd Length: 143 Bit Score: 47.74 E-value: 1.56e-06
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*...
gi 351065690 373 QKQRLAALSAFRSKTLQVIICTDVASRGLDIPHVDLVVNHNVPQCPKTYIHRVGRSAR 430
Cdd:cd18801 76 QKEQKEVIEQFRKGGYNVLVATSIGEEGLDIGEVDLIICYDASPSPIRMIQRMGRTGR 133
|
|
| DEXHc_RE |
cd17926 |
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family ... |
135-275 |
1.64e-06 |
|
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family is composed of helicase restriction enzymes and similar proteins such as TFIIH basal transcription factor complex helicase XPB subunit. These proteins are part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350684 [Multi-domain] Cd Length: 146 Bit Score: 47.69 E-value: 1.64e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 135 TGTGKTLaFAIPILQKLSVDPygiyALILTPTRELAFQIAEQFTALGKPITLKcsvIVGGRSLIHQARELserphVVVAT 214
Cdd:cd17926 27 TGSGKTL-TALALIAYLKELR----TLIVVPTDALLDQWKERFEDFLGDSSIG---LIGGGKKKDFDDAN-----VVVAT 93
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 351065690 215 PgrlaDLIESDPDTIAKVFKKIQFFVLDEADRmLEGqynDQLKPIFESISEKRQtLLLSAT 275
Cdd:cd17926 94 Y----QSLSNLAEEEKDLFDQFGLLIVDEAHH-LPA---KTFSEILKELNAKYR-LGLTAT 145
|
|
| SF2_C_RecG_TRCF |
cd18792 |
C-terminal helicase domain of the RecG family helicases; The DEAD-like helicase RecG family ... |
362-432 |
2.20e-06 |
|
C-terminal helicase domain of the RecG family helicases; The DEAD-like helicase RecG family contains recombination factor RecG and transcription-repair coupling factor TrcF. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350179 [Multi-domain] Cd Length: 160 Bit Score: 47.65 E-value: 2.20e-06
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 351065690 362 FRVGSLHSQIPQKQRLAALSAFRSKTLQVIICTDVASRGLDIPHVDLVVNHNVPQCPKTYIH----RVGRSARAG 432
Cdd:cd18792 61 ARVALLHGKMTEDEKEAVMLEFREGEYDILVSTTVIEVGIDVPNANTMIIEDADRFGLSQLHqlrgRVGRGKHQS 135
|
|
| RecQ |
COG0514 |
Superfamily II DNA helicase RecQ [Replication, recombination and repair]; |
315-450 |
2.80e-06 |
|
Superfamily II DNA helicase RecQ [Replication, recombination and repair];
Pssm-ID: 440280 [Multi-domain] Cd Length: 489 Bit Score: 50.14 E-value: 2.80e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 315 CPVAVKDAYLVYVVKnyseKNPKSSVMIFAQTCRECQALAYMFEGLGFRVGSLHSQIPQKQRLAALSAFRSKTLQVIICT 394
Cdd:COG0514 212 KPPDDKLAQLLDFLK----EHPGGSGIVYCLSRKKVEELAEWLREAGIRAAAYHAGLDAEEREANQDRFLRDEVDVIVAT 287
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 351065690 395 dVA-SRGLDIPHVDLVVNHNVPQCPKTYIHRVGRSARAGRFGSALSFVTQYDVELLQ 450
Cdd:COG0514 288 -IAfGMGIDKPDVRFVIHYDLPKSIEAYYQEIGRAGRDGLPAEALLLYGPEDVAIQR 343
|
|
| SF2_C_RecG |
cd18811 |
C-terminal helicase domain of DNA helicase RecG; ATP-dependent DNA helicase RecG plays a ... |
322-429 |
2.92e-06 |
|
C-terminal helicase domain of DNA helicase RecG; ATP-dependent DNA helicase RecG plays a critical role in recombination and DNA repair. RecG helps process Holliday junction intermediates to mature products by catalyzing branch migration. It is a DEAD-like helicase belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350198 [Multi-domain] Cd Length: 159 Bit Score: 47.34 E-value: 2.92e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 322 AYLVYVVKNYSEK-NPKSSVmifaqtcRECQALAYMFEGlGFRVGSLHSQIPQKQRLAALSAFRSKTLQVIICTDVASRG 400
Cdd:cd18811 29 AYVIYPLIEESEKlDLKAAV-------AMYEYLKERFRP-ELNVGLLHGRLKSDEKDAVMAEFREGEVDILVSTTVIEVG 100
|
90 100 110
....*....|....*....|....*....|...
gi 351065690 401 LDIPHVDLVVNHNVPQCPKTYIH----RVGRSA 429
Cdd:cd18811 101 VDVPNATVMVIEDAERFGLSQLHqlrgRVGRGD 133
|
|
| SF2_C_LHR |
cd18796 |
C-terminal helicase domain of LHR family helicases; Large helicase-related protein (LHR) is a ... |
313-430 |
1.80e-05 |
|
C-terminal helicase domain of LHR family helicases; Large helicase-related protein (LHR) is a DNA damage-inducible helicase that uses ATP hydrolysis to drive unidirectional 3'-to-5' translocation along single-stranded DNA (ssDNA) and to unwind RNA:DNA duplexes. This group also includes related bacterial and archaeal helicases. LHR family helicases are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350183 [Multi-domain] Cd Length: 150 Bit Score: 44.95 E-value: 1.80e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 313 VVCPVAVKDAYLVYVVKNYSEKN------PKSSVMIFAQTCRECQALAYMF------EGLGFRVGSLHSQIPQKQRLAAL 380
Cdd:cd18796 8 VILPVAPEIFPWAGESGADAYAEviflleRHKSTLVFTNTRSQAERLAQRLrelcpdRVPPDFIALHHGSLSRELREEVE 87
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 351065690 381 SAFRSKTLQVIICTDVASRGLDIPHVDLVVNHNVPQCPKTYIHRVGRSAR 430
Cdd:cd18796 88 AALKRGDLKVVVATSSLELGIDIGDVDLVIQIGSPKSVARLLQRLGRSGH 137
|
|
| SF2_C_EcoAI-like |
cd18799 |
C-terminal helicase domain of EcoAI HsdR-like restriction enzyme family helicases; This family ... |
339-410 |
2.12e-05 |
|
C-terminal helicase domain of EcoAI HsdR-like restriction enzyme family helicases; This family is composed of helicase restriction enzymes, including the HsdR subunit of restriction-modification enzymes such as Escherichia coli type I restriction enzyme EcoAI R protein (R.EcoAI). The EcoAI enzyme recognizes 5'-GAGN(7)GTCA-3'. The HsdR or R subunit is required for both nuclease and ATPase activities, but not for modification. These proteins are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350186 [Multi-domain] Cd Length: 116 Bit Score: 43.70 E-value: 2.12e-05
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 351065690 339 SVMIFAQTCRECQALAYMFEGLGFRVGSLHSQIPQKQRL---AALSAFRSKTLQVIICTDVASRGLDIPHVDLVV 410
Cdd:cd18799 8 KTLIFCVSIEHAEFMAEAFNEAGIDAVALNSDYSDRERGdeaLILLFFGELKPPILVTVDLLTTGVDIPEVDNVV 82
|
|
| SF2_C_RecQ |
cd18794 |
C-terminal helicase domain of the RecQ family helicases; The RecQ helicase family is an ... |
329-435 |
4.70e-05 |
|
C-terminal helicase domain of the RecQ family helicases; The RecQ helicase family is an evolutionarily conserved class of enzymes, dedicated to preserving genomic integrity by operating in telomere maintenance, DNA repair, and replication. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350181 [Multi-domain] Cd Length: 134 Bit Score: 43.35 E-value: 4.70e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 329 KNYSEKNPKSSVMIFAQTCRECQALAYMFEGLGFRVGSLHSQIPQKQRLAALSAFRSKTLQVIICTDVASRGLDIPHVDL 408
Cdd:cd18794 22 KRIKVEHLGGSGIIYCLSRKECEQVAARLQSKGISAAAYHAGLEPSDRRDVQRKWLRDKIQVIVATVAFGMGIDKPDVRF 101
|
90 100
....*....|....*....|....*..
gi 351065690 409 VVNHNVPQCPKTYIHRVGrsaRAGRFG 435
Cdd:cd18794 102 VIHYSLPKSMESYYQESG---RAGRDG 125
|
|
| DEXHc_RecG |
cd17918 |
DEXH/Q-box helicase domain of DEAD-like helicase RecG family proteins; The DEAD-like helicase ... |
111-277 |
7.13e-05 |
|
DEXH/Q-box helicase domain of DEAD-like helicase RecG family proteins; The DEAD-like helicase RecG family is part of the DEAD-like helicases superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350676 [Multi-domain] Cd Length: 180 Bit Score: 43.56 E-value: 7.13e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 111 TATPVQAACIPKIL------EGSDILGCARTGTGKTLAFAIPILQKLSVdpyGIYALILTPTRELAFQIAEQFTALGKPI 184
Cdd:cd17918 15 SLTKDQAQAIKDIEkdlhspEPMDRLLSGDVGSGKTLVALGAALLAYKN---GKQVAILVPTEILAHQHYEEARKFLPFI 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 185 tlKCSVIVGGRslihQARELSErPHVVVATPGrladLIESDpdtiaKVFKKIQFFVLDEADRMLEGQYndqlkpifESIS 264
Cdd:cd17918 92 --NVELVTGGT----KAQILSG-ISLLVGTHA----LLHLD-----VKFKNLDLVIVDEQHRFGVAQR--------EALY 147
|
170
....*....|...
gi 351065690 265 EKRQTLLLSATIT 277
Cdd:cd17918 148 NLGATHFLEATAT 160
|
|
| DEXHc_ASCC3_1 |
cd18020 |
N-terminal DEXH-box helicase domain of Activating signal cointegrator 1 complex subunit 3; ... |
128-296 |
1.15e-04 |
|
N-terminal DEXH-box helicase domain of Activating signal cointegrator 1 complex subunit 3; Activating signal cointegrator 1 complex subunit 3 (ASCC3) is a type II DEAD box helicase that plays a role in the repair of N-alkylated nucleotides. ASCC3 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350778 [Multi-domain] Cd Length: 199 Bit Score: 43.57 E-value: 1.15e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 128 DILGCARTGTGKTLAFAIPILQKLS--VDPYG---------IYaliLTPTRELAFQIAEQFTALGKPITLKCSVIVGGRS 196
Cdd:cd18020 19 NMLICAPTGAGKTNIAMLTILHEIRqhVNQGGvikkddfkiVY---IAPMKALAAEMVEKFSKRLAPLGIKVKELTGDMQ 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 197 LihQARELSErPHVVVATPGRLaDLIESDPDTIAKVFKKIQFFVLDEAdRMLegqyNDQLKPIFESI-------SEKRQT 269
Cdd:cd18020 96 L--TKKEIAE-TQIIVTTPEKW-DVVTRKSSGDVALSQLVRLLIIDEV-HLL----HDDRGPVIESLvartlrqVESTQS 166
|
170 180 190
....*....|....*....|....*....|...
gi 351065690 270 LL----LSATITNNINMLH--RVSTRKPYFFED 296
Cdd:cd18020 167 MIrivgLSATLPNYLDVADflRVNPYKGLFFFD 199
|
|
| DEXHc_dicer |
cd18034 |
DEXH-box helicase domain of endoribonuclease Dicer; Dicer ribonucleases cleave double-stranded ... |
127-244 |
2.41e-04 |
|
DEXH-box helicase domain of endoribonuclease Dicer; Dicer ribonucleases cleave double-stranded RNA (dsRNA) precursors to generate microRNAs (miRNAs) and small interfering RNAs (siRNAs). In concert with Argonautes, these small RNAs bind complementary mRNAs to down-regulate their expression. miRNAs are processed by Dicer from small hairpins, while siRNAs are typically processed from longer dsRNA, from endogenous sources, or exogenous sources such as viral replication intermediates. Some organisms, such as Homo sapiens and Caenorhabditis elegans, encode one Dicer that generates miRNAs and siRNAs, but other organisms have multiple dicers with specialized functions. Dicers exist throughout eukaryotes, and a subset have an N-terminal helicase domain of the RIG-I-like receptor (RLR) subgroup. RLRs often function in innate immunity and Dicer helicase domains sometimes show differences in activity that correlate with roles in immunity. Dicer is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350792 [Multi-domain] Cd Length: 200 Bit Score: 42.64 E-value: 2.41e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 127 SDILGCARTGTGKTLaFAIPILQKLSVDPYGIY-----ALILTPTRELAFQiaeQFTALGKPITLKCSVIVGGRSLIHQA 201
Cdd:cd18034 17 RNTIVVLPTGSGKTL-IAVMLIKEMGELNRKEKnpkkrAVFLVPTVPLVAQ---QAEAIRSHTDLKVGEYSGEMGVDKWT 92
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 351065690 202 R----ELSERPHVVVATPGRLADLIESdpdtiAKV-FKKIQFFVLDEA 244
Cdd:cd18034 93 KerwkEELEKYDVLVMTAQILLDALRH-----GFLsLSDINLLIFDEC 135
|
|
| SF2_C_TRCF |
cd18810 |
C-terminal helicase domain of the transcription-repair coupling factor; Transcription-repair ... |
363-432 |
6.52e-04 |
|
C-terminal helicase domain of the transcription-repair coupling factor; Transcription-repair coupling factor (TrcF) dissociates transcription elongation complexes blocked at nonpairing lesions and mediates recruitment of DNA repair proteins. TrcF is a DEAD-like helicase belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350197 [Multi-domain] Cd Length: 151 Bit Score: 40.40 E-value: 6.52e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 351065690 363 RVGSLHSQIPQKQRLAALSAFRSKTLQVIICTDVASRGLDIPHVDLVVNHNVPQCPKTYIH----RVGRSARAG 432
Cdd:cd18810 53 RIAIAHGQMTENELEEVMLEFAKGEYDILVCTTIIESGIDIPNANTIIIERADKFGLAQLYqlrgRVGRSKERA 126
|
|
| DEXHc_HFM1 |
cd18023 |
DEXH-box helicase domain of ATP-dependent DNA helicase HFM1; HFM1 is a type II DEAD box ... |
115-243 |
8.88e-04 |
|
DEXH-box helicase domain of ATP-dependent DNA helicase HFM1; HFM1 is a type II DEAD box helicase, required for crossover formation and complete synapsis of homologous chromosomes during meiosis. HFM1 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350781 [Multi-domain] Cd Length: 206 Bit Score: 40.80 E-value: 8.88e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 115 VQAACIPKILEgSDI--LGCARTGTGKTLAFAIPILQKL----SVDPYGIYALILTPTRELAFQIAEQFTALGKPITLKC 188
Cdd:cd18023 5 IQSEVFPDLLY-SDKnfVVSAPTGSGKTVLFELAILRLLkernPLPWGNRKVVYIAPIKALCSEKYDDWKEKFGPLGLSC 83
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 351065690 189 SVIVGGRSlIHQARELSErPHVVVATPGRLaDLIESDPDTIAKVFKKIQFFVLDE 243
Cdd:cd18023 84 AELTGDTE-MDDTFEIQD-ADIILTTPEKW-DSMTRRWRDNGNLVQLVALVLIDE 135
|
|
| SF2_C_reverse_gyrase |
cd18798 |
C-terminal helicase domain of the reverse gyrase; Reverse gyrase modifies the topological ... |
351-464 |
8.98e-04 |
|
C-terminal helicase domain of the reverse gyrase; Reverse gyrase modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. Reverse gyrase is a DEAD-like helicase belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350185 [Multi-domain] Cd Length: 174 Bit Score: 40.37 E-value: 8.98e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 351 QALAYMFEGLGFRVGSLHSQIPQKqrlaaLSAFRSKTLQVIIctDVAS------RGLDIPH-VDLVVNHNVPqcPKTYIH 423
Cdd:cd18798 41 EELKEFLERHGIKAELALSSTEKN-----LEKFEEGEIDVLI--GVASyygvlvRGIDLPErIKYAIFYGVP--VTTYIQ 111
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 351065690 424 RVGRSAR--AGRFGSALSFVTQYDVELLQAVEQVIGKKLDELK 464
Cdd:cd18798 112 ASGRTSRlyAGGLTKGLSVVLVDDPELFEALKKRLKLILDEFI 154
|
|
| PRK11057 |
PRK11057 |
ATP-dependent DNA helicase RecQ; Provisional |
361-445 |
1.06e-03 |
|
ATP-dependent DNA helicase RecQ; Provisional
Pssm-ID: 182933 [Multi-domain] Cd Length: 607 Bit Score: 42.01 E-value: 1.06e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 361 GFRVGSLHSQIPQKQRLAALSAFRSKTLQVIICTDVASRGLDIPHVDLVVNHNVPQCPKTYIHRVGRSARAGRFGSALSF 440
Cdd:PRK11057 260 GISAAAYHAGLDNDVRADVQEAFQRDDLQIVVATVAFGMGINKPNVRFVVHFDIPRNIESYYQETGRAGRDGLPAEAMLF 339
|
....*
gi 351065690 441 vtqYD 445
Cdd:PRK11057 340 ---YD 341
|
|
| HepA |
COG0553 |
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, ... |
340-411 |
2.19e-03 |
|
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, and repair];
Pssm-ID: 440319 [Multi-domain] Cd Length: 682 Bit Score: 40.98 E-value: 2.19e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 351065690 340 VMIFAQTCRECQALAYMFEGLGFRVGSLHSQIPQKQRLAALSAFRSK--TLQVIICTDVASRGLDIPHVDLVVN 411
Cdd:COG0553 552 VLVFSQFTDTLDLLEERLEERGIEYAYLHGGTSAEERDELVDRFQEGpeAPVFLISLKAGGEGLNLTAADHVIH 625
|
|
| DEXHc_RecQ |
cd17920 |
DEXH-box helicase domain of RecQ family proteins; The RecQ family of the type II DEAD box ... |
114-244 |
8.67e-03 |
|
DEXH-box helicase domain of RecQ family proteins; The RecQ family of the type II DEAD box helicase superfamily is a family of highly conserved DNA repair helicases. This domain contains the ATP-binding region.
Pssm-ID: 350678 [Multi-domain] Cd Length: 200 Bit Score: 37.90 E-value: 8.67e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 114 PVQAACIPKILEGSDILGCARTGTGKTLAFAIP--ILQKLsvdpygiyALILTPTRELAFQIAEQFTALGKPitlkcSVI 191
Cdd:cd17920 15 PGQLEAINAVLAGRDVLVVMPTGGGKSLCYQLPalLLDGV--------TLVVSPLISLMQDQVDRLQQLGIR-----AAA 81
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 351065690 192 VGGRSLIHQARELSER-----PHVVVATPGRLA-----DLIESDPdtiakVFKKIQFFVLDEA 244
Cdd:cd17920 82 LNSTLSPEEKREVLLRikngqYKLLYVTPERLLspdflELLQRLP-----ERKRLALIVVDEA 139
|
|
| uvrb |
TIGR00631 |
excinuclease ABC, B subunit; All proteins in this family for wich functions are known are DNA ... |
328-505 |
9.77e-03 |
|
excinuclease ABC, B subunit; All proteins in this family for wich functions are known are DNA helicases that function in the nucleotide excision repair and are endonucleases that make the 3' incision next to DNA damage. They are part of a pathway requiring UvrA, UvrB, UvrC, and UvrD homologs. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University) [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273185 [Multi-domain] Cd Length: 655 Bit Score: 38.82 E-value: 9.77e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 328 VKNYSEKNPKssVMIFAQTCRECQALAYMFEGLGFRVGSLHSQIPQKQRLAALSAFRSKTLQVIICTDVASRGLDIPHVD 407
Cdd:TIGR00631 435 IRQRVARNER--VLVTTLTKKMAEDLTDYLKELGIKVRYLHSEIDTLERVEIIRDLRLGEFDVLVGINLLREGLDLPEVS 512
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351065690 408 LV--VNHNVPQCPKTY---IHRVGRSARAGRfGSALSF---VTQYDVELLQAVEQVIGKKLD---ELKVSPKHVTKYVTQ 476
Cdd:TIGR00631 513 LVaiLDADKEGFLRSErslIQTIGRAARNVN-GKVIMYadkITDSMQKAIEETERRRKIQMAyneEHGITPQTIRKPIRD 591
|
170 180 190
....*....|....*....|....*....|
gi 351065690 477 VLVAK-KEAELKLENQKFGEKKEINRRKEL 505
Cdd:TIGR00631 592 ILDIElKEKEDAAKKKKKGEDLSDLSKKEL 621
|
|
| |
