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Conserved domains on  [gi|373218746|emb|CCD62897|]
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G-protein coupled receptors family 1 profile domain-containing protein [Caenorhabditis elegans]

Protein Classification

class D serpentine receptor( domain architecture ID 10563389)

class D serpentine receptor (Srd) belongs to a family of seven-transmembrane (7TM) G protein-coupled receptors involved in chemoreception, a central sense of soil nematodes like Caenorhabditis elegans

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
7TM_GPCR_Srd pfam10317
Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis ...
 11-305 7.00e-79

Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srd is part of the larger Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


:

Pssm-ID: 402094  Cd Length: 292  Bit Score: 242.84  E-value: 7.00e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373218746   11 VKSWHIFFGITGVILNLVLILLVVFKSPNAIRVYSRLITNFAVTDFLACLLDIFIEIRVLPspNEATITYILNGFCTYFG 90
Cdd:pfam10317   1 FSIYYPIFFILGLILNLLLLYLIIFKSPKSLKTYRILLLNTAITQIISCILAFFTQQRIIP--NGVSMALISYGPCKYFG 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373218746   91 LSTCAIGLSMYIHTLTHSLWSLFISFVFRYLILYKVSLKEKHILLALFVFYIPSFVQAATYWTSFVDSSTILPITKRIYP 170
Cdd:pfam10317  79 PWFCYSGYSLLQHFLLHSGWSLLLTFYYRYYILKHVDPKRKKLILLIIIHYIPSLSQLIVIFLSPTDFLPVEALTKELHP 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373218746  171 QYNFELETglITGITNLFSVSAIYAVLHMTIPVTPVYITIFILRRKILKTLMMSYNVMSKETKAIHAQLMKALTFQAFIP 250
Cdd:pfam10317 159 NYNLTDYT--VTGFSDLQSFPALINTLIMTIPVFPIPIIILILRRKILKLLNSNSVNMSPTTKAQHRQLIKGLTIQALLP 236

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 373218746  251 VAAW-AAVYVYIGMQFGIISGIFFEYMVFSTVIFMPLLSPVAYLVYVRPYRLYILR 305
Cdd:pfam10317 237 LFSYiPGVTLYLLSQLTGTEFLILEYFIFVLPALPPLLDPLITIYFVTPYRRAILR 292
 
Name Accession Description Interval E-value
7TM_GPCR_Srd pfam10317
Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis ...
 11-305 7.00e-79

Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srd is part of the larger Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402094  Cd Length: 292  Bit Score: 242.84  E-value: 7.00e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373218746   11 VKSWHIFFGITGVILNLVLILLVVFKSPNAIRVYSRLITNFAVTDFLACLLDIFIEIRVLPspNEATITYILNGFCTYFG 90
Cdd:pfam10317   1 FSIYYPIFFILGLILNLLLLYLIIFKSPKSLKTYRILLLNTAITQIISCILAFFTQQRIIP--NGVSMALISYGPCKYFG 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373218746   91 LSTCAIGLSMYIHTLTHSLWSLFISFVFRYLILYKVSLKEKHILLALFVFYIPSFVQAATYWTSFVDSSTILPITKRIYP 170
Cdd:pfam10317  79 PWFCYSGYSLLQHFLLHSGWSLLLTFYYRYYILKHVDPKRKKLILLIIIHYIPSLSQLIVIFLSPTDFLPVEALTKELHP 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373218746  171 QYNFELETglITGITNLFSVSAIYAVLHMTIPVTPVYITIFILRRKILKTLMMSYNVMSKETKAIHAQLMKALTFQAFIP 250
Cdd:pfam10317 159 NYNLTDYT--VTGFSDLQSFPALINTLIMTIPVFPIPIIILILRRKILKLLNSNSVNMSPTTKAQHRQLIKGLTIQALLP 236

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 373218746  251 VAAW-AAVYVYIGMQFGIISGIFFEYMVFSTVIFMPLLSPVAYLVYVRPYRLYILR 305
Cdd:pfam10317 237 LFSYiPGVTLYLLSQLTGTEFLILEYFIFVLPALPPLLDPLITIYFVTPYRRAILR 292
 
Name Accession Description Interval E-value
7TM_GPCR_Srd pfam10317
Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis ...
 11-305 7.00e-79

Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srd is part of the larger Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402094  Cd Length: 292  Bit Score: 242.84  E-value: 7.00e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373218746   11 VKSWHIFFGITGVILNLVLILLVVFKSPNAIRVYSRLITNFAVTDFLACLLDIFIEIRVLPspNEATITYILNGFCTYFG 90
Cdd:pfam10317   1 FSIYYPIFFILGLILNLLLLYLIIFKSPKSLKTYRILLLNTAITQIISCILAFFTQQRIIP--NGVSMALISYGPCKYFG 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373218746   91 LSTCAIGLSMYIHTLTHSLWSLFISFVFRYLILYKVSLKEKHILLALFVFYIPSFVQAATYWTSFVDSSTILPITKRIYP 170
Cdd:pfam10317  79 PWFCYSGYSLLQHFLLHSGWSLLLTFYYRYYILKHVDPKRKKLILLIIIHYIPSLSQLIVIFLSPTDFLPVEALTKELHP 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373218746  171 QYNFELETglITGITNLFSVSAIYAVLHMTIPVTPVYITIFILRRKILKTLMMSYNVMSKETKAIHAQLMKALTFQAFIP 250
Cdd:pfam10317 159 NYNLTDYT--VTGFSDLQSFPALINTLIMTIPVFPIPIIILILRRKILKLLNSNSVNMSPTTKAQHRQLIKGLTIQALLP 236

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 373218746  251 VAAW-AAVYVYIGMQFGIISGIFFEYMVFSTVIFMPLLSPVAYLVYVRPYRLYILR 305
Cdd:pfam10317 237 LFSYiPGVTLYLLSQLTGTEFLILEYFIFVLPALPPLLDPLITIYFVTPYRRAILR 292
7TM_GPCR_Srj pfam10319
Serpentine type 7TM GPCR chemoreceptor Srj; Chemoreception is mediated in Caenorhabditis ...
 112-300 5.16e-05

Serpentine type 7TM GPCR chemoreceptor Srj; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srj is part of the Str superfamily of chemoreceptors. The srj family is designated as the out-group based on its location in preliminary phylogenetic analyses of the entire superfamily. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 370974  Cd Length: 310  Bit Score: 44.54  E-value: 5.16e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373218746  112 LFISFVFRYLILYKVSLKEKH-------ILLALFVFYIpSFVQAATYWTSFVDSST---ILPITKRIYPQ--YNFELETG 179
Cdd:pfam10319 106 LLIHFIYRYLVLFNPQLTRHYfrpwgilISILFFLFHG-SVWTAICYFLLRANDEIrdyIREDFRETYGVdsMDINMLGA 184

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373218746  180 LITGITNLFSVSAIYAVLHMTIPVTPVYITIFILRRKILKTLMMSYNVMSKETKAIHAQLMKALTFQAFIPVAAWAA--V 257
Cdd:pfam10319 185 LYWEASDETVFRSWLGILLLTVISVYSIILYIVLGYKIMRKLNKMSVTMSKKTKRLQKQLLKALIVQTIIPICISFSpcV 264

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 373218746  258 YVYIGMQFGIISGIFFEYMVFSTVIFMPLLSPVAYLVYVRPYR 300
Cdd:pfam10319 265 LAWYSPIFGIDLGRWNNYLEVIALSAFPFIDPLAIILCLPVYR 307
7TM_GPCR_Srh pfam10318
Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis ...
 56-309 3.68e-04

Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srh is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402095  Cd Length: 302  Bit Score: 41.76  E-value: 3.68e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373218746   56 FLACLLDIFIEIRVLPSPNEATITYILNGFCTYFGLST---CAIGLSMYIHTLThslwSLFISFVFRYLIL---YKVSLK 129
Cdd:pfam10318  48 FWSALLDLSLSFLTIPYIFLPALAGYPLGLLSYLGVPTpiqFYIGVTSLALVGV----SIILLFENRYSILftnKKRITW 123

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373218746  130 EKHILLALFVFYIPSFVQAATYWTSFVDSSTILPITKRIYP---QYNFELETGLITGITNLFSVsaIYAVLHMTIPVTPV 206
Cdd:pfam10318 124 KKTRVLYLIFNYIIALLFLIPIYLNIPDQEAAKLKVLKKLPclpPEFFDNPPVFVLAIDSTYFL--ICIVLLILILIIQI 201

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373218746  207 YITIFILRRKILKTLMMSynvMSKETKAIHAQLMKALTFQAFIPVAAWAAVYVYIGmqFGIISGIFFEYMVFSTVIFMP- 285
Cdd:pfam10318 202 LFFVFLTIYYLFKSVKSS---LSKKTRKLQKKFFIALIIQVSIPLIVILIPLIYIL--FSIIFGYYNQALNNLLFIIISl 276

                         250       260
                  ....*....|....*....|....*.
gi 373218746  286 --LLSPVAYLVYVRPYRLYILRTFCR 309
Cdd:pfam10318 277 hgLLSTIAMLLVHKPYRKFVLSLFKK 302
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
 34-304 2.89e-03

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402099  Cd Length: 307  Bit Score: 38.98  E-value: 2.89e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373218746   34 VFKSPNAIRVYSRLITNFAVTDFLACLLDIFIEirvlpsPN----EATITYILNGFCTYFGLSTCAIGLSMYIHTLTHSL 109
Cdd:pfam10326  24 LFKSPKIFGTYKYLMIYFSIFGIFFSILEFIVK------PFihsyNSSFIVFVDLKDLGLSKSVGQILLALYCGFYGVSI 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373218746  110 WSLFISFVFRYLILYKVSL----KEKHILLALFVFYIPSFVQA-ATYWTSFVDSSTILPITKRIYPQYNFELE----TGL 180
Cdd:pfam10326  98 SLLAVQFIYRYLALCRPGKlkyfDGKKLILWFLYPLIFGAIWGlLVYFFLGPDEETDEYLREELLENYNLDIDevayVGP 177

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373218746  181 I------TGITNLFSVSAIYAVLHMTIPVTPvYITIFILRRKILKTLMMSYNVMSKETKAIHAQLMKALTFQAFIPV--- 251
Cdd:pfam10326 178 VyyptdeNGSKVIRWRSLIGLLIMTFIIGIS-FSIIIYCGIKMYFKMKKLKSLGSEKTRKLQKQLFKALVIQTLIPTilm 256

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 373218746  252 ---AAWAAVYVYIGMQFGIISGIffeymVFSTVIFMPLLSPVAYLVYVRPYRLYIL 304
Cdd:pfam10326 257 yipVGILFLLPLFNIEIGFLSGI-----ITATIALYPAIDPLPAMFIIKEYRNAIK 307
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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