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Conserved domains on  [gi|373218935|emb|CCD64361|]
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Major facilitator superfamily (MFS) profile domain-containing protein [Caenorhabditis elegans]

Protein Classification

MFS transporter( domain architecture ID 999995)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26758938|26098515
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS super family cl28910
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 89-332 8.31e-28

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


The actual alignment was detected with superfamily member cd17318:

Pssm-ID: 475125 [Multi-domain]  Cd Length: 389  Bit Score: 114.25  E-value: 8.31e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373218935  89 EKSILFSATAIGALVALIPSVPILNSLGVRLTLSFCGLCSTLGTFFTPLAVTYSFYLVVFCRVLQGIGISVILTVLGVIP 168
Cdd:cd17318   57 TQGIILSSFFYGYILTQIPGGYLAEKYGAKRVLGYSILITALLTLLTPLAARGGYGALIVLRILQGLAQGVTFPAMHALW 136

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373218935 169 SYWSPKTEYSTYLAILSCAWQFSNVIFMPISGILCdSSFGWRSIYYVFGVatgffyfvffmfytdipgihknvsekeLGQ 248
Cdd:cd17318  137 AKWAPPLERSRLTSIAYSGSQFGTVIAMPLSGFLC-ESLGWPSIFYIFGG---------------------------LGL 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373218935 249 IVegkpehtvreAVPYWKICtdRCVLSAWVSFLGGNLGFITLLLYGPTYLREVLQFDVRSTGYINALPYALCAIYKFGAG 328
Cdd:cd17318  189 LW----------CLLWFFLV--LPVWAIVVAHFGHNWGFYTLLTELPTYMSDVLHFNIKSNGFLSSLPYLAMWICSIVGG 256


                 ....
gi 373218935 329 KISD 332
Cdd:cd17318  257 YLAD 260
 
Name Accession Description Interval E-value
MFS_SLC17 cd17318
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ...
 89-332 8.31e-28

Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340876 [Multi-domain]  Cd Length: 389  Bit Score: 114.25  E-value: 8.31e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373218935  89 EKSILFSATAIGALVALIPSVPILNSLGVRLTLSFCGLCSTLGTFFTPLAVTYSFYLVVFCRVLQGIGISVILTVLGVIP 168
Cdd:cd17318   57 TQGIILSSFFYGYILTQIPGGYLAEKYGAKRVLGYSILITALLTLLTPLAARGGYGALIVLRILQGLAQGVTFPAMHALW 136

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373218935 169 SYWSPKTEYSTYLAILSCAWQFSNVIFMPISGILCdSSFGWRSIYYVFGVatgffyfvffmfytdipgihknvsekeLGQ 248
Cdd:cd17318  137 AKWAPPLERSRLTSIAYSGSQFGTVIAMPLSGFLC-ESLGWPSIFYIFGG---------------------------LGL 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373218935 249 IVegkpehtvreAVPYWKICtdRCVLSAWVSFLGGNLGFITLLLYGPTYLREVLQFDVRSTGYINALPYALCAIYKFGAG 328
Cdd:cd17318  189 LW----------CLLWFFLV--LPVWAIVVAHFGHNWGFYTLLTELPTYMSDVLHFNIKSNGFLSSLPYLAMWICSIVGG 256


                 ....
gi 373218935 329 KISD 332
Cdd:cd17318  257 YLAD 260
2A0114euk TIGR00894
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
 92-332 2.32e-25

Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]


Pssm-ID: 129972 [Multi-domain]  Cd Length: 465  Bit Score: 108.29  E-value: 2.32e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373218935   92 ILFSATAIGALVALIPSVPILNSLGVRLTLSFCGLCSTLGTFFTPLAVTYSFYLVVFCRVLQGIGISVILTVLGVIPSYW 171
Cdd:TIGR00894  80 LILSSHFYGQIIIQIPVGYLAGKYVFKWSIGIGMFLSSVISIVIPWAAGGGIALVVFCRVIQGLAQGSVSPATHKIIVKW 159

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373218935  172 SPKTEYSTYLAILSCAWQFSNVIFMPISGILCDSSFGWRSIYYVFGVATGFFYFVFFMFYTDIPGIHKNVSEKE---LGQ 248
Cdd:TIGR00894 160 APPKERSRLLGMSTSGFQLGTFIFLPISGWLCESWGGWPMIFYVFGIVGCAWSLLWFVFPADDPSIHPCISKFEkkyINS 239

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373218935  249 IVEGKpEHTVREAVPYWKICTDRCVLSAWVSFLGGNLGFITLLLYGPTYLREVLQFDVRSTGYINALPYALCAIYKFGAG 328
Cdd:TIGR00894 240 SLQGQ-KGSTRQSLPIKAIPKSLPVWAIWFAIFGHFWLYTILPTYLPTFISWVLRVSGKENGLLSSLPYLFAWLCSIFAG 318


                  ....
gi 373218935  329 KISD 332
Cdd:TIGR00894 319 YLAD 322
MFS_1 pfam07690
Major Facilitator Superfamily;
88-334 8.81e-22

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 96.33  E-value: 8.81e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373218935   88 TEKSILFSATAIGALVALIPSVPILNSLGVRLTLSFCGLCSTLGTFFtpLAVTYSFYLVVFCRVLQGIGISVILTVLGVI 167
Cdd:pfam07690  32 TEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLL--LLFASSLWLLLVLRVLQGLGAGALFPAALAL 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373218935  168 PSYWSPKTEYSTYLAILSCAWQFSNVIFMPISGILCDsSFGWRSIYYVFGVATGFFYFVFFMFYTDIPGIHKNVSEKELG 247
Cdd:pfam07690 110 IADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLAS-LFGWRAAFLILAILSLLAAVLLLLPRPPPESKRPKPAEEARL 188

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373218935  248 QIVEGkpehtvreavpyWKICTDRCVLSAWVSFLGGNLGFITLLLYGPTYLrEVLQFDVRSTGYINALPYALCAIYKFGA 327
Cdd:pfam07690 189 SLIVA------------WKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQ-EVLGLSALLAGLLLGLGGLLGAIGRLLL 255


                  ....*..
gi 373218935  328 GKISDRV 334
Cdd:pfam07690 256 GRLSDRL 262
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
38-334 2.24e-19

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 89.54  E-value: 2.24e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373218935  38 RVFILILSLTCMTLTQINSQIFTFTvicMDDLIVEQQTSNltephwiegtTEKSILFSATAIGALVALIPSVPILNSLGV 117
Cdd:COG2271    8 RWRILALLFLAYFLNYLDRSNLSVA---APPLQADLGLSA----------AQLGLLASAFFLGYALGQIPAGLLADRFGR 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373218935 118 RLTLSFCGLCSTLGTFFTPLAVtySFYLVVFCRVLQGIGISVILTVLGVIPSYWSPKTEYSTYLAILSCAWQFSNVIFMP 197
Cdd:COG2271   75 RRVLAIGLLLWGLATLLFGFAT--SFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPP 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373218935 198 ISGILCDsSFGWRSIYYVFGVATgffyfvffmfytdipgihknvsekelgqIVEGkpehtvreAVPYWKIctdrcvlsaW 277
Cdd:COG2271  153 LLGWLLA-AFGWRAAFLILGLPG----------------------------LLLA--------LLRFWLL---------A 186

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 373218935 278 VSFLGGNLGFITLLLYGPTYLREVLQFDVRSTGYINALPYALCAIYKFGAGKISDRV 334
Cdd:COG2271  187 LAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRL 243
 
Name Accession Description Interval E-value
MFS_SLC17 cd17318
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ...
 89-332 8.31e-28

Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340876 [Multi-domain]  Cd Length: 389  Bit Score: 114.25  E-value: 8.31e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373218935  89 EKSILFSATAIGALVALIPSVPILNSLGVRLTLSFCGLCSTLGTFFTPLAVTYSFYLVVFCRVLQGIGISVILTVLGVIP 168
Cdd:cd17318   57 TQGIILSSFFYGYILTQIPGGYLAEKYGAKRVLGYSILITALLTLLTPLAARGGYGALIVLRILQGLAQGVTFPAMHALW 136

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373218935 169 SYWSPKTEYSTYLAILSCAWQFSNVIFMPISGILCdSSFGWRSIYYVFGVatgffyfvffmfytdipgihknvsekeLGQ 248
Cdd:cd17318  137 AKWAPPLERSRLTSIAYSGSQFGTVIAMPLSGFLC-ESLGWPSIFYIFGG---------------------------LGL 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373218935 249 IVegkpehtvreAVPYWKICtdRCVLSAWVSFLGGNLGFITLLLYGPTYLREVLQFDVRSTGYINALPYALCAIYKFGAG 328
Cdd:cd17318  189 LW----------CLLWFFLV--LPVWAIVVAHFGHNWGFYTLLTELPTYMSDVLHFNIKSNGFLSSLPYLAMWICSIVGG 256


                 ....
gi 373218935 329 KISD 332
Cdd:cd17318  257 YLAD 260
2A0114euk TIGR00894
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
 92-332 2.32e-25

Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]


Pssm-ID: 129972 [Multi-domain]  Cd Length: 465  Bit Score: 108.29  E-value: 2.32e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373218935   92 ILFSATAIGALVALIPSVPILNSLGVRLTLSFCGLCSTLGTFFTPLAVTYSFYLVVFCRVLQGIGISVILTVLGVIPSYW 171
Cdd:TIGR00894  80 LILSSHFYGQIIIQIPVGYLAGKYVFKWSIGIGMFLSSVISIVIPWAAGGGIALVVFCRVIQGLAQGSVSPATHKIIVKW 159

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373218935  172 SPKTEYSTYLAILSCAWQFSNVIFMPISGILCDSSFGWRSIYYVFGVATGFFYFVFFMFYTDIPGIHKNVSEKE---LGQ 248
Cdd:TIGR00894 160 APPKERSRLLGMSTSGFQLGTFIFLPISGWLCESWGGWPMIFYVFGIVGCAWSLLWFVFPADDPSIHPCISKFEkkyINS 239

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373218935  249 IVEGKpEHTVREAVPYWKICTDRCVLSAWVSFLGGNLGFITLLLYGPTYLREVLQFDVRSTGYINALPYALCAIYKFGAG 328
Cdd:TIGR00894 240 SLQGQ-KGSTRQSLPIKAIPKSLPVWAIWFAIFGHFWLYTILPTYLPTFISWVLRVSGKENGLLSSLPYLFAWLCSIFAG 318


                  ....
gi 373218935  329 KISD 332
Cdd:TIGR00894 319 YLAD 322
MFS_1 pfam07690
Major Facilitator Superfamily;
88-334 8.81e-22

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 96.33  E-value: 8.81e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373218935   88 TEKSILFSATAIGALVALIPSVPILNSLGVRLTLSFCGLCSTLGTFFtpLAVTYSFYLVVFCRVLQGIGISVILTVLGVI 167
Cdd:pfam07690  32 TEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLL--LLFASSLWLLLVLRVLQGLGAGALFPAALAL 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373218935  168 PSYWSPKTEYSTYLAILSCAWQFSNVIFMPISGILCDsSFGWRSIYYVFGVATGFFYFVFFMFYTDIPGIHKNVSEKELG 247
Cdd:pfam07690 110 IADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLAS-LFGWRAAFLILAILSLLAAVLLLLPRPPPESKRPKPAEEARL 188

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373218935  248 QIVEGkpehtvreavpyWKICTDRCVLSAWVSFLGGNLGFITLLLYGPTYLrEVLQFDVRSTGYINALPYALCAIYKFGA 327
Cdd:pfam07690 189 SLIVA------------WKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQ-EVLGLSALLAGLLLGLGGLLGAIGRLLL 255


                  ....*..
gi 373218935  328 GKISDRV 334
Cdd:pfam07690 256 GRLSDRL 262
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
38-334 2.24e-19

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 89.54  E-value: 2.24e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373218935  38 RVFILILSLTCMTLTQINSQIFTFTvicMDDLIVEQQTSNltephwiegtTEKSILFSATAIGALVALIPSVPILNSLGV 117
Cdd:COG2271    8 RWRILALLFLAYFLNYLDRSNLSVA---APPLQADLGLSA----------AQLGLLASAFFLGYALGQIPAGLLADRFGR 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373218935 118 RLTLSFCGLCSTLGTFFTPLAVtySFYLVVFCRVLQGIGISVILTVLGVIPSYWSPKTEYSTYLAILSCAWQFSNVIFMP 197
Cdd:COG2271   75 RRVLAIGLLLWGLATLLFGFAT--SFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPP 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373218935 198 ISGILCDsSFGWRSIYYVFGVATgffyfvffmfytdipgihknvsekelgqIVEGkpehtvreAVPYWKIctdrcvlsaW 277
Cdd:COG2271  153 LLGWLLA-AFGWRAAFLILGLPG----------------------------LLLA--------LLRFWLL---------A 186

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 373218935 278 VSFLGGNLGFITLLLYGPTYLREVLQFDVRSTGYINALPYALCAIYKFGAGKISDRV 334
Cdd:COG2271  187 LAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRL 243
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
91-334 5.87e-19

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 88.11  E-value: 5.87e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373218935  91 SILFSATAIGALVALIPSVPILNSLGVRLTLSFCGLCSTLGTFFTPLAVtySFYLVVFCRVLQGIGISVILTVLGVIPSY 170
Cdd:COG2814   48 GLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAP--SLWLLLAARFLQGLGAGALFPAALALIAD 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373218935 171 WSPKTEYSTYLAILSCAWQFSNVIFMPISGILCDSsFGWRSIYYVFGVATGFFYFVFfmfytdipgihknvsekeLGQIV 250
Cdd:COG2814  126 LVPPERRGRALGLLGAGLGLGPALGPLLGGLLADL-FGWRWVFLVNAVLALLALLLL------------------LRLLP 186

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373218935 251 EGKPEHTVREAVPYWKICTDRCVLSAWVSFLGGNLGFITLLLYGPTYLREVLQFDVRSTGYINALPYALCAIYKFGAGKI 330
Cdd:COG2814  187 ESRPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRL 266


                 ....
gi 373218935 331 SDRV 334
Cdd:COG2814  267 ADRF 270
MFS_SLC17A5 cd17381
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of ...
 100-332 1.44e-16

Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of transporters; Solute carrier family 17 member 5 (SLC17A5) is also called sialin, H(+)/nitrate cotransporter, H(+)/sialic acid cotransporter (AST), membrane glycoprotein HP59, or vesicular H(+)/aspartate-glutamate cotransporter. It transports glucuronic acid and free sialic acid out of the lysosome after its cleavage from sialoglycoconjugates, which is required for normal CNS myelination. It also mediates the membrane potential-dependent uptake of aspartate and glutamate into synaptic vesicles and synaptic-like microvesicles. In the plasma membrane, it functions as a nitrate transporter. Recessive mutations in the SLC17A5 gene cause the allelic disorders, Infantile sialic acid storage disease (ISSD) and Salla disease (a predominantly neurological disorder). SLC17A5 belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340939 [Multi-domain]  Cd Length: 397  Bit Score: 81.36  E-value: 1.44e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373218935 100 GALVALIPSVPILNSLGVRLTLSFCGLCSTLGTFFTPLAVTYSFYLVVFCRVLQGIGISVILTVLGVIPSYWSPKTEYST 179
Cdd:cd17381   77 GYIITQIPGGYLASKIGGKLLLGFGILGTAVFTLLTPLAADLGAGYLIAVRALEGLGEGVTFPAMHAMWASWAPPLERSR 156

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373218935 180 YLAILSCAWQFSNVIFMPISGILCdSSFGWRSIYYVFGvATGFFYFVFFMFYTdipgihknvsekelgqivegkpehtvr 259
Cdd:cd17381  157 LLTISYAGAQLGTVVSLPLSGLIC-YYLDWTYVFYIFG-AVGLLWFFLWIWLV--------------------------- 207

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 373218935 260 eaVPYWKICtdrcvlsawVSFLGGNLGFITLLLYGPTYLREVLQFDVRSTGYINALPYALCAIYKFGAGKISD 332
Cdd:cd17381  208 --MPLWAIV---------VAHFSYNWTFYTLLTLLPTYMKEILRFDIQENGFLSALPYLGCWLFMILSGQIAD 269
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
87-334 2.18e-16

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 80.70  E-value: 2.18e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373218935  87 TTEKSILFSATAIGALVALIPSVPILNSLGVRLTLSFCGLCSTLGTFFTPLAVTYSFYLVvfCRVLQGIGISVILTVLGV 166
Cdd:COG2223   39 AAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVSYWLLLL--LGLLLGIGGGGSFAVGIA 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373218935 167 IPSYWSPKTEYSTYLAILSCAWQFSNVIFMPISGILcDSSFGWRSIYYVFGVATGFFYFVFFMFYTDIPGIHKNVSEKEL 246
Cdd:COG2223  117 LVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLL-IAAFGWRNAFLILGILLLVVAVLAWLFLRDPPAGAAAAAKASL 195

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373218935 247 GQivegkpehtvreavpYWKICTDRCVLSAWVSFLGGNLGFITLLLYGPTYLREVLQFDVRSTGYINALPYALCAIYKFG 326
Cdd:COG2223  196 RD---------------QLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPL 260


                 ....*...
gi 373218935 327 AGKISDRV 334
Cdd:COG2223  261 GGWLSDRI 268
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 86-425 6.73e-14

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 72.84  E-value: 6.73e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373218935  86 GTTEKSILFSATAIGALVALIPSVPILNSLGVRLTLSFCGLCSTLGTFFtpLAVTYSFYLVVFCRVLQGIGISVILTVLG 165
Cdd:cd06174   29 SASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALL--FAFAPSFWLLLLGRFLLGLGSGLIDPAVL 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373218935 166 VIPSYWSPKTEYSTYLAILSCAWQFSNVIFMPISGILCDS-SFGWRSIYYVFGVATGFFYFVFFMFYTDIPGihknvsek 244
Cdd:cd06174  107 ALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSlGFGWRAVFLIAAALALLAAILLLLVVPDPPE-------- 178

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373218935 245 elGQIVEGKPEHTVREAVPYWKICTDRCVLSAWVSFLGGNLGFITLLLYGPTYLREVLQFDVRSTGYINALPYALCAIYK 324
Cdd:cd06174  179 --SARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGS 256

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373218935 325 FGAGKISDRVTFASDKAIYTFWLFSsiiglgIGYIIMAWTSDRNVAFVAFAFAVVTSGLIIMACVKCLAMRCQQHC-HFA 403
Cdd:cd06174  257 LLLGLLSDRLIGRKPLLLIGLLLMA------LGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIrGTA 330

                        330       340
                 ....*....|....*....|..
gi 373218935 404 VSAISFLSYCVQFISPLGVGIL 425
Cdd:cd06174  331 FGLLNTFGFLGGAIGPLLAGFL 352
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 87-334 1.02e-12

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 69.14  E-value: 1.02e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373218935  87 TTEKSILFSATAIGALVALIPSVPILNSLGVRLTLSFCGLcsTLGTFFTPLAVTYSFYLVVFCRVLQGIGISVILTVLGV 166
Cdd:cd17319   37 PTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSML--LWSLFTALTGFATSLTSLYVLRFLLGVAEAGFFPGAIK 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373218935 167 IPSYWSPKTEYSTYLAILSCAWQFSNVIFMPISGILCdSSFGWRSIYYVFGVATGffyfvffmfytdIPGIhknvsekel 246
Cdd:cd17319  115 ALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLL-LLFGWRWAFIIEGLLGL------------LLAV--------- 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373218935 247 gqivegkpehTVREAVP-YWKICtdrcvlsawVSFLGGNLGFITLLLYGPTYLREVLQFDVRSTGYINALPYALCAIYKF 325
Cdd:cd17319  173 ----------LWWFYLRqVWGLA---------LGYFGINYALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMI 233


                 ....*....
gi 373218935 326 GAGKISDRV 334
Cdd:cd17319  234 LGGRLSDRL 242
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 91-334 1.82e-11

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 65.68  E-value: 1.82e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373218935  91 SILFSATAIGALVALIPSVPILNSLGVRLTLSFCGLCSTLGTFFTPLAVTYSFYLVVfcRVLQGIGISVILTVLGVIPSY 170
Cdd:cd17325   34 GLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLA--RFLQGLASAAVWPAAMALIAD 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373218935 171 WSPKTEYSTYLAILSCAWQFSNVIFMPISGILcDSSFGWRSIYYVFGVATGFFYFVFFMFYtdipgihknvseKELGQIV 250
Cdd:cd17325  112 IAPPEERGRAMGIFSSAIGLGFLIGPLLGGLL-ADALGYRAPFLVCAALALLALVLALLLL------------PEPRPPP 178

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373218935 251 EGKPEHTVREAVPYWKICTDRCVLSAWVSFLGGNLGFITLLLYGPTYLREVLQFDVRSTGYINALPYALCAIYKFGAGKI 330
Cdd:cd17325  179 NKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKL 258


                 ....
gi 373218935 331 SDRV 334
Cdd:cd17325  259 SDRI 262
MFS_SLC17A9_like cd17380
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ...
 88-333 1.85e-11

Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340938 [Multi-domain]  Cd Length: 361  Bit Score: 65.27  E-value: 1.85e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373218935  88 TEKSILFSATAIGALVALIPSVPILNSLGVRLTLSFCGLCSTLGTFFTPLAVTYSFYLVVFCRVLQGIGISVILTVLGVI 167
Cdd:cd17380   34 TDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATLLTPLLAYSSLPLLILSRILLGLGEGVHFPSMTSL 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373218935 168 PSYWSPKTEYSTYLAILSCAWQFSNVIFMPISGILCDsSFGWRSIYYVFGVatgffyfvffmfytdipgihknvsekeLG 247
Cdd:cd17380  114 FSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLE-YYGWPSVFYFFGL---------------------------LG 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373218935 248 QIvegkpehtvreavpyWKICTDRCVLSAW---VSFLGGNLGFITLLLYGPTYLREVLqFDVRSTGYINALPYALCAIYK 324
Cdd:cd17380  166 LL---------------WALVWLIYLPPVWaiiVAHFCMNWGFYILLSWLPTYFHEVL-VPLAKGWVFNVVPWLVMFPSS 229


                 ....*....
gi 373218935 325 FGAGKISDR 333
Cdd:cd17380  230 NVAGWLADH 238
MFS_SLC17A6_7_8_VGluT cd17382
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of ...
 134-333 1.48e-09

Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of the Major Facilitator Superfamily of transporters; This subfamily is composed of solute carrier family 17 member 6 (SLC17A6), SLC17A7, SLC17A8, and similar proteins. SLC17A6 is also called vesicular glutamate transporter 2 (VGluT2), differentiation-associated BNPI, or differentiation-associated Na(+)-dependent inorganic phosphate cotransporter. SLC17A7 is also called VGluT1 or brain-specific Na(+)-dependent inorganic phosphate cotransporter. SLC17A8 is also called VGluT3. They mediate the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells, and may also mediate the transport of inorganic phosphate. VGluTs are also expressed and localized in various secretory vesicles in non-neuronal peripheral organelles such as hormone-containing secretory granules in endocrine cells, and thus, also act as metabolic regulators. The VGluT subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340940 [Multi-domain]  Cd Length: 380  Bit Score: 59.66  E-value: 1.48e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373218935 134 FTPLAVTYSFYLVVFCRVLQGIGISVILTVLGVIPSYWSPKTEYSTYLAILSCAWQFSNVIFMPISGILCDsSFGWRSIY 213
Cdd:cd17382   95 LIPIAARVHYGCVIFVRILQGLVEGVTYPACHGIWRKWAPPLERSRLATTAFCGSYAGAVVGMPLSGILVQ-YVGWSSPF 173

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373218935 214 YVFGVatgffyfvffmfytdipgihknvsekeLGQIvegkpehtvreavpyWKI---CTDRCVLSAWVSFLGGNLGFITL 290
Cdd:cd17382  174 YVYGV---------------------------FGII---------------WYMfwmLVSMPVYAIIVANFCRSWTFYLL 211

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 373218935 291 LLYGPTYLREVLQFDVRSTGYINALPYALCAIYKFGAGKISDR 333
Cdd:cd17382  212 LISQPAYFKEVFGFDISKVGILSALPHLVMTIIVPIGGQLADY 254
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 91-333 3.01e-08

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 55.63  E-value: 3.01e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373218935  91 SILFSATAIGALVALIPSVPILNSLGVRLTLSFCGLCSTLGTFFTPLAVtySFYLVVFCRVLQGIGISVILTVLGVIPSY 170
Cdd:cd17324   37 GLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAP--SFALLLLARALAGLAHGGFWAIAAAYAAD 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373218935 171 WSPKTEYSTYLAILSCAWQFSNVIFMPISGILCDsSFGWRSIYYVFGVATGFFYFVFFMFYTDIPGiHKNVSEKELGQiv 250
Cdd:cd17324  115 LVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQ-LLGWRAAFLAIAVLALLAALLLWRLLPSLPP-KKPGSLGLLSS-- 190

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373218935 251 egkpehtvreavpYWKICTDRCVLSAWVSFLGGNLGFITLLLYGPTYLREVLQFDVRSTGYINALPYALCAIYKFGAGKI 330
Cdd:cd17324  191 -------------LLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRL 257


                 ...
gi 373218935 331 SDR 333
Cdd:cd17324  258 ADR 260
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
91-334 3.75e-08

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 55.25  E-value: 3.75e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373218935  91 SILFSATAIGALVALIPSVPILNSLGVRLTLSFCGLCSTLGTFFTPLAVTYSFYLVVFcrVLQGIGISVILTVLGVIPSY 170
Cdd:COG0738   46 GLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLLAL--FLLGLGLGLLDVAANPYVAA 123

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373218935 171 WSPKTEySTYLAILSCAWQFSNVIFMPISG--ILCDSSFGWRSIYYVFGVATGffYFVFFMFYTDIPGIhknvsekelgq 248
Cdd:COG0738  124 LGPETA-ASRLNLLHAFFSLGALLGPLLGGllILLGLSLSWHLPYLILAVLLL--LLALLFLRSKLPEI----------- 189

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373218935 249 ivEGKPEHTVREAVPYWKICTDRCVLSAWVSFLGGNLGFITLLLYGPTYLREVLQFDVRSTGYINALPYALCAIYKFGAG 328
Cdd:COG0738  190 --EEEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGG 267


                 ....*.
gi 373218935 329 KISDRV 334
Cdd:COG0738  268 FLLKRF 273
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 86-215 6.41e-07

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 50.97  E-value: 6.41e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373218935  86 GTTEKSILFSATAIGALVALIPSVPILNSLGVRLTLSFCGLCSTLGTFFTPLAVTysFYLVVFCRVLQGIGISVILTVLG 165
Cdd:COG0477   47 SSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLAPS--PELLIAARALQGIGAGGLMPGAL 124

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 373218935 166 VIPSYWSPKTEYSTYLAILSCAWQFSNVIfMPISGILCDSSFGWRSIYYV 215
Cdd:COG0477  125 ALIAELFPARERGRALGLWGAAIGLGLAL-GPLLGGLLVAALGWRWIFLI 173
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
 49-220 9.64e-07

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 50.82  E-value: 9.64e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373218935   49 MTLTQINSQIFTFTVICMD--DLIVEQQTSNLTEPHWIEGTTEKSILFSATAIGALVALIPSVPILNSLGVRLTLSFCGL 126
Cdd:TIGR00895  11 LSRYQWRAIILSFLIMLMDgyDLAAMGFAAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSIL 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373218935  127 CSTLGTFFTPLAVTYSfYLVVFcRVLQGIGISVILTVLGVIPSYWSPKTEYSTYLAILSCAWQFSNVIFMPISGILCdSS 206
Cdd:TIGR00895  91 LFSVFTLLCALATNVT-QLLIL-RFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLI-PV 167

                         170
                  ....*....|....
gi 373218935  207 FGWRSIYYVFGVAT 220
Cdd:TIGR00895 168 FGWRSLFYVGGIAP 181
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 91-219 2.03e-06

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 49.88  E-value: 2.03e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373218935  91 SILFSATAIGALVALIPSVPILNslgvrLTLSFCGLCSTLGTFFTplavtySFYLVVFCRVLQGIGISVILTV-LGVIPS 169
Cdd:cd17473   47 FIALFAPLAGWLADRFGRKRLLI-----AGLLLYGIGGVAGLFLD------SLYALLASRALLGIGVAGIMTLaTALIGD 115

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 373218935 170 YWSpKTEYSTYLAILSCAWQFSNVIFMPISGILcdSSFGWRSIYYVFGVA 219
Cdd:cd17473  116 YFE-GEERAKMLGLQSAAMSLGGVVFLLLGGAL--AEIGWRAPFLVYLLA 162
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 92-218 4.98e-05

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 45.26  E-value: 4.98e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373218935  92 ILFSATAIGALVALIPSVPILNSLGVRLTLSFCGLCSTLGTFFTPLAVtySFYLVVFCRVLQGIGISVILTVLGVIPSYW 171
Cdd:cd17325  239 LLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLAT--SFWLLLLLLALLGLGLGLVFPATLALLADI 316

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 373218935 172 SPKTEYSTYLAILSCAWQFSNVIFMPISGILCDsSFGWRSIYYVFGV 218
Cdd:cd17325  317 VPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYD-AFGFATPFLAAAA 362
MFS_Azr1_MDR_like cd17502
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ...
 115-215 6.87e-05

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341045 [Multi-domain]  Cd Length: 337  Bit Score: 44.86  E-value: 6.87e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373218935 115 LGVRLTLSFCGLCSTLGTFFTPLAVtySFYLVVFCRVLQGIGISVILTVLGVIPSYWSPKTEYSTYLAILSCAWQFSNVI 194
Cdd:cd17502   57 FGRKWVLLIAIVIFELGSLLCGLAP--NMTMLIVGRAIQGIGGGGLMSLAFIIIADLVPPRERGKYQGYIGAVFGIASVA 134

                         90       100
                 ....*....|....*....|.
gi 373218935 195 FMPISGILCDsSFGWRSIYYV 215
Cdd:cd17502  135 GPLIGGAFTD-HLSWRWCFYI 154
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 79-334 4.84e-04

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 42.20  E-value: 4.84e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373218935  79 TEPHWIEGTTEKSILFSATAIGALVALIPSVPILNSLGVRLTLSFCGLCSTLGTFFTPLAVTYSFYLVvfCRVLQGIGIS 158
Cdd:cd17316   27 AEFSLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTPILLLV--LRFLQGIGIG 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373218935 159 VILTVLGVIPSYWSPKTEYSTYLAILSCAWQFSNVIFMPISGILCDS---SFGWRSIYYVFGvatgffyfvffmfytdIP 235
Cdd:cd17316  105 GEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLlsgDWGWRILFLIGA----------------LP 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373218935 236 GIhknvsekelgqivegkpehtvreAVPYWKictdRCVLSAWVSFLGGNLGFITLLLYGPTYLREVLQFDVRSTGYINAL 315
Cdd:cd17316  169 AL-----------------------LALLLR----RRTLLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLL 221

                        250
                 ....*....|....*....
gi 373218935 316 PYALCAIYKFGAGKISDRV 334
Cdd:cd17316  222 ISLGALVGALIAGLLSDRI 240
MFS_FEN2_like cd17327
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ...
 99-333 6.20e-04

Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340885 [Multi-domain]  Cd Length: 406  Bit Score: 41.85  E-value: 6.20e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373218935  99 IGALVALIPSVPILNSLGVRLTLSFCGLCSTLGTFFTPLAVTYSFYLVVfcRVLQGIGISVILTVLGVIPSYWSPKTEYS 178
Cdd:cd17327   52 VGYIIFELPGNLLLQRFPPSKWLSVFIVLWGLLTLLTAAVKNFGGLIAL--RFFLGLFESGVFPGFILYLGMWYKREEQA 129

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373218935 179 TYLAILSCAWQFSNVI--FMP--ISGILCDSSF-GWRSIYYVFGVATGFFYFVFFMFYTDIPGIHKNVSEKELGQIVE-- 251
Cdd:cd17327  130 KRIAFFYAAAGLGSIFggLLAygVFKILGVGGLaGWRWLFIIEGLITIIIGLVIFFWLPDNPSKAWFLTEEEKELAVErl 209

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373218935 252 -----GKPEH-----TVREAVPYWKIctdrcvlsaWVSFLGGNLGFITLLLYG---PTYLREvLQFDVRSTGYINALPYA 318
Cdd:cd17327  210 ranqtGKGDQkfkwkQIKEAFKDPRT---------WLLFLFFFCSQITNNGISnflPLILKS-LGFYSLQTNLLSVPIGA 279

                        250
                 ....*....|....*
gi 373218935 319 LCAIYKFGAGKISDR 333
Cdd:cd17327  280 LGAVSLLIAALLSDR 294
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
 98-220 1.11e-03

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 41.03  E-value: 1.11e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373218935  98 AIGALVAlipsVPILNSLGVRLTLSFCGLCSTLGTFFTPLAVtySFYLVVFCRVLQGIGISVILTVLGVIPSYWSPKTEY 177
Cdd:cd17365   48 AIGALLA----GPLADRFGRKRVLLVSVALFGLFTLLTAFAQ--SVLQLALLRFLTGLGLGAAMPNAITLVSEYAPARRR 121

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 373218935 178 STYLAILSCAWQFSNVIFMPISGILCDsSFGWRSIYYVFGVAT 220
Cdd:cd17365  122 SLAVTLMFCGYPLGAALGGFLAAALIP-AFGWRSVFLLGGVPP 163
MFS_FucP_MFSD4_like cd17333
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ...
 91-345 1.74e-03

Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340891 [Multi-domain]  Cd Length: 372  Bit Score: 40.38  E-value: 1.74e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373218935  91 SILFSATAIGALVALIPSVPILNSLGVRLTLSFCGLCSTLGTFftPLAVTYSFYLVVFCRVLQGIGISVILTVLGVIPSY 170
Cdd:cd17333   34 SVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALA--LIFATPSIYLFVVLMFLAGLGAGILDTGANTFVGA 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373218935 171 WSPKTEySTYLAILSCAWQFSNVIFMPISGILCDSSFGWRSIYYV---FGVATGFFYFVFFMFYTDIPGIHKnvsekelg 247
Cdd:cd17333  112 LFEESS-ATRLNVLHGFFGLGALIGPLIATSLLTSELSWSWAYLIiglIYLLLAILILLTLFPELPSARNPQ-------- 182

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373218935 248 QIVEGKPEHTVREA-VPYWkictdrcVLSAWVSFLGGnLGFITLLLYGPTYLREVLQFDVRSTGYINALPYALCAIYKFG 326
Cdd:cd17333  183 QSVGAFSASASRLLrNPSI-------ILGALALFLYV-GAETAFSSWVPSYLVEKKHVSDGLAGYLLSGFWVGITIGRLL 254

                        250
                 ....*....|....*....
gi 373218935 327 AGKISDRVTFASDKAIYTF 345
Cdd:cd17333  255 GGPISRRIKPHTLLVLSGS 273
MFS_OPA_SLC37 cd17312
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ...
 91-218 1.99e-03

Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340870 [Multi-domain]  Cd Length: 364  Bit Score: 40.33  E-value: 1.99e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373218935  91 SILFSATAIGALVALIPSvpilNSLGVRLTLSFCGLCSTLGTFFtpLAVTYSFYLVVFCRVL----QGIGISVILTVLGv 166
Cdd:cd17312   45 SAFLIAYAVGKFISGFLS----DRSNIRRFMSAGLLLSALANIF--MGFSTSLWFFAVLWGLnglfQSMGWPPCVKLLG- 117

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 373218935 167 ipSYWSPKtEYSTYLAILSCAWQFSNVIFMPISGILCdSSFGWRSIYYVFGV 218
Cdd:cd17312  118 --NWFSKK-ERGTVYGIWSTSHNFGGILAPILAASLA-SYYGWRAAFLVPGI 165
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
 127-215 2.70e-03

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 39.87  E-value: 2.70e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373218935 127 CSTLGTFFTPLAVtySFYLVVFCRVLQGIGISVILTVLGVIPSYWSPKTEYSTyLAILSCAWQFSNVIFMPISGILCDsS 206
Cdd:cd17504   70 IYTAGSLLAAFAP--NLPVLIAGRALQGIGGAVFPLAFALVREEFPPERVPVA-QGILSATFGIGAGIGLPLGGWIVQ-H 145


                 ....*....
gi 373218935 207 FGWRSIYYV 215
Cdd:cd17504  146 LGWRWIFWT 154
MFS_unc93_like cd17338
Unc-93 family of the Major Facilitator Superfamily of transporters; The Unc-93 family is ...
 86-335 3.25e-03

Unc-93 family of the Major Facilitator Superfamily of transporters; The Unc-93 family is composed of Caenorhabditis elegans uncoordinated protein 93 (also called putative potassium channel regulatory protein unc-93) and similar proteins including three vertebrate members: protein unc-93 homolog A (UNC93A), protein unc-93 homolog B1 (UNC93B1), and UNC93-like protein MFSD11 (also called major facilitator superfamily domain-containing protein 11 or protein ET). Unc-93 acts as a regulatory subunit of a multi-subunit potassium channel complex that may function in coordinating muscle contraction in C. elegans. The human UNC93A gene is located in a region of the genome that is frequently associated with ovarian cancer, however, there is no evidence that UNC93A has a tumor suppressor function. UNC93B1 controls intracellular trafficking and transport of a subset of Toll-like receptors (TLRs), including TLR3, TLR7 and TLR9, from the endoplasmic reticulum to endolysosomes where they can engage pathogen nucleotides and activate signaling cascades. MFSD11 is ubiquitously expressed in the periphery and the central nervous system of mice, where it is expressed in excitatory and inhibitory mouse brain neurons. The unc93-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340896 [Multi-domain]  Cd Length: 388  Bit Score: 39.64  E-value: 3.25e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373218935  86 GTTEKSILFSATAIGALVAlipsVPILNSLGVRLTLsfcgLCSTLG-TFFTPLAVTYSFYLVVFCRVLQGIGISVILTVL 164
Cdd:cd17338   31 GSISLGILYSSFAVSSFIA----PLLVKLLGEKITL----VLGGLGyAIFIASNIFPIWGTLVPASIILGFAAAILWTAQ 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373218935 165 GVIPSYWSPKTEYSTYLAILSCAWQFSNVIFMPISGILCD---SSFGWRSIYYVFGVATGFFYFVFFMfytdIPGIHKNV 241
Cdd:cd17338  103 GTYITRISDESNIGRNFGIFWSIFQLSQVFGNLISLALLNhskGSSGTTILFIVFMAIMLVGIILLFF----LRGPDNEV 178

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373218935 242 SEKELGQIVEGKPEhtVREAVPY-WKICTDRCVLSAWVSFLggNLGFITLLLYGpTYLREVLQ--FDVRSTGYINALPYA 318
Cdd:cd17338  179 ITEIESSSVGESME--KKNLFKLpFTLLKDKRFLLLIPLLI--YSGLEQTFFSG-VFTLIIGTptTGIARVGYVMAVYGF 253

                        250
                 ....*....|....*..
gi 373218935 319 LCAIYKFGAGKISDRVT 335
Cdd:cd17338  254 GDALGSLVAGLLSDWRF 270
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
 91-218 3.76e-03

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 39.48  E-value: 3.76e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373218935  91 SILFSATAIGALVAlipsVPILNSLGVRLTLSFCGLCSTLGTFFtpLAVTYSFYLVVFCRVLQGIGISVILTVLGVIP-- 168
Cdd:cd17320   41 SAYLLGFALGQLLY----GPLSDRFGRRPVLLAGLLLFILASLL--CALASSIEQLLIARFLQGLGAAAGSVVARAIVrd 114

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 373218935 169 SYwsPKTEYSTYLAILSCAWQFSNVIfMPISGILCDSSFGWRSIYYVFGV 218
Cdd:cd17320  115 LY--SGAELAKIFSLLMMILAIAPAL-APLLGGLLLLFFGWRAIFVFLAL 161
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 91-219 5.29e-03

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 38.95  E-value: 5.29e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373218935  91 SILFSATAIGALVALIPSVPILN-SLGVRLTLSFCGLCSTLGTFFTPLAVTYSFYLVVFCrvLQGIGISVILTVLGVIPS 169
Cdd:cd06174  242 GLLLSLFGLAGALGSLLLGLLSDrLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLL--LLGFGLGGLLPLSFALIA 319

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 373218935 170 YWSPKTEYSTYLAILSCAWQFSNVIFMPISGILCDSSFGWRSIYYVFGVA 219
Cdd:cd06174  320 ELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVL 369
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 91-333 5.45e-03

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 39.09  E-value: 5.45e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373218935  91 SILFSATAIGALVALIPSVPILNSLGVRLTLSFCGLCSTLGTFFTplAVTYSFYLVVFCRVLQGIGISVIL-TVLGVIPS 169
Cdd:cd17474   37 GLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLC--GLSDSFALLLAGRALQGIGAAGLGpLALTLIGD 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373218935 170 YWSPKtEYSTYLAILSCAWQFSNVIFMPISGILcdSSFGWRSIYYVFGVATGFFYFVFFMfytdipgIHKNVSEKElgqi 249
Cdd:cd17474  115 LFEGG-ERAKAMGLYEAALGLGIAVGPLLGGLL--AAISWRYPFFLLAALIPVAFLAILF-------LLPEPKEKA---- 180

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373218935 250 vEGKPEHTVREAVpywKICTDRCVLSAWVSFLGGNLGFITLLLYGPTYLREVLQFDVRSTGYINALPYALCAIYKFGAGK 329
Cdd:cd17474  181 -KSSSATKLRDLK---KALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLLALGSLFVGR 256


                 ....
gi 373218935 330 ISDR 333
Cdd:cd17474  257 LLKK 260
2A0104 TIGR00881
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ...
 88-217 6.10e-03

phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273319 [Multi-domain]  Cd Length: 379  Bit Score: 38.90  E-value: 6.10e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373218935   88 TEKSILFSATAIGALVALIPSVPILNSLGVRLTLSF----CGLCSTLGTFFTPLAVTysFYLVVFCRVLQGIGISVILTV 163
Cdd:TIGR00881  30 TDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIglilCAIVNLFFGFSTSLWVM--AALWALNGIFQGMGWPPCGRT 107

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 373218935  164 LgvipSYWSPKTEYSTYLAILSCAWQFSNVIFMPISGILCDSSFGWRSIYYVFG 217
Cdd:TIGR00881 108 V----TKWFSRSERGTWVSFWNCSHNVGGGLLPPLVLFGIAELYSWHWVFIVPG 157
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 129-215 8.54e-03

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 38.31  E-value: 8.54e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373218935 129 TLGTFFTPLAVTYSFylVVFCRVLQGIGISVILTVLGVIPSYWSPKTEYSTYLAILSCAWQFSNVIFMPISGILCDsSFG 208
Cdd:cd17321   72 GLASLLCALAPSLAF--LIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLE-LFG 148


                 ....*..
gi 373218935 209 WRSIYYV 215
Cdd:cd17321  149 WRWIFLI 155
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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