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Conserved domains on  [gi|373219514|emb|CCD68336|]
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Dienelactone hydrolase domain-containing protein [Caenorhabditis elegans]

Protein Classification

dienelactone hydrolase family protein( domain architecture ID 10785456)

dienelactone hydrolase family protein plays a crucial role in chlorocatechol degradation via the modified ortho cleavage pathway

CATH:  3.40.50.1820
EC:  3.-.-.-
Gene Ontology:  GO:0016787
PubMed:  19508187|12369917
SCOP:  3000102

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
DLH COG0412
Dienelactone hydrolase [Secondary metabolites biosynthesis, transport and catabolism];
5-241 6.86e-51

Dienelactone hydrolase [Secondary metabolites biosynthesis, transport and catabolism];


:

Pssm-ID: 440181 [Multi-domain]  Cd Length: 226  Bit Score: 165.52  E-value: 6.86e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373219514   5 QTIDYEDADGNLFSGELYKPssDNSTKHPGVLIFPAFRGVSKLEIARAKLLAEeHGYVALVADIYGKGIRCTDISSAVTL 84
Cdd:COG0412    4 ETVTIPTPDGVTLPGYLARP--AGGGPRPGVVVLHEIFGLNPHIRDVARRLAA-AGYVVLAPDLYGRGGPGDDPDEARAL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373219514  85 LRPMTSDRngkLKPRLEAALNALKSVPCVDKQKLGAFGFCIGGLCSLDCARyRFDGIRAVISFHGTLTPIEGIPLEQLDD 164
Cdd:COG0412   81 MGALDPEL---LAADLRAALDWLKAQPEVDAGRVGVVGFCFGGGLALLAAA-RGPDLAAAVSFYGGLPADDLLDLAARIK 156
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 373219514 165 IFIQVHHGDADAHVSKVTVDAFHEEMRARNSDFVFISHGKAMHSFTDPESAeiapsgvGYDANADKRSWKATLEFLK 241
Cdd:COG0412  157 APVLLLYGEKDPLVPPEQVAALEAALAAAGVDVELHVYPGAGHGFTNPGRP-------RYDPAAAEDAWQRTLAFLA 226
 
Name Accession Description Interval E-value
DLH COG0412
Dienelactone hydrolase [Secondary metabolites biosynthesis, transport and catabolism];
5-241 6.86e-51

Dienelactone hydrolase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 440181 [Multi-domain]  Cd Length: 226  Bit Score: 165.52  E-value: 6.86e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373219514   5 QTIDYEDADGNLFSGELYKPssDNSTKHPGVLIFPAFRGVSKLEIARAKLLAEeHGYVALVADIYGKGIRCTDISSAVTL 84
Cdd:COG0412    4 ETVTIPTPDGVTLPGYLARP--AGGGPRPGVVVLHEIFGLNPHIRDVARRLAA-AGYVVLAPDLYGRGGPGDDPDEARAL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373219514  85 LRPMTSDRngkLKPRLEAALNALKSVPCVDKQKLGAFGFCIGGLCSLDCARyRFDGIRAVISFHGTLTPIEGIPLEQLDD 164
Cdd:COG0412   81 MGALDPEL---LAADLRAALDWLKAQPEVDAGRVGVVGFCFGGGLALLAAA-RGPDLAAAVSFYGGLPADDLLDLAARIK 156
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 373219514 165 IFIQVHHGDADAHVSKVTVDAFHEEMRARNSDFVFISHGKAMHSFTDPESAeiapsgvGYDANADKRSWKATLEFLK 241
Cdd:COG0412  157 APVLLLYGEKDPLVPPEQVAALEAALAAAGVDVELHVYPGAGHGFTNPGRP-------RYDPAAAEDAWQRTLAFLA 226
DLH pfam01738
Dienelactone hydrolase family;
31-242 8.41e-45

Dienelactone hydrolase family;


Pssm-ID: 396343 [Multi-domain]  Cd Length: 213  Bit Score: 149.42  E-value: 8.41e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373219514   31 KHPGVLIFPAFRGVSK--LEIARAklLAEEhGYVALVADIYGKGIRCTDISSAVTLLRPMTSDRN-GKLKPRLEAALNAL 107
Cdd:pfam01738  11 PWPVVVVFQEIFGVNDniREIADR--LADE-GYVALAPDLYFRQGDPNDEADAARAMFELVSKRVmEKVLDDLEAAVNYL 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373219514  108 KSVPCVDKQKLGAFGFCIGGLCSLDCARyRFDGIRAVISFHGTLTPiegIPLEQLDDIF--IQVHHGDADAHVSKVTVDA 185
Cdd:pfam01738  88 KSQPEVSPKKVGVVGYCMGGALAVLLAA-KGPLVDAAVGFYGVGPE---PPLIEAPDIKapILFHFGEEDHFVPADSREL 163
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 373219514  186 FHEEMRARNSDFVFISHGKAMHSFTdpesaeiAPSGVGYDANADKRSWKATLEFLKE 242
Cdd:pfam01738 164 IEEALKAANVDHQIHSYPGAGHAFA-------NDSRPSYNAAAAEDAWERTLEFFKQ 213
frsA PRK05077
esterase FrsA;
102-127 6.42e-03

esterase FrsA;


Pssm-ID: 235337  Cd Length: 414  Bit Score: 37.20  E-value: 6.42e-03
                         10        20
                 ....*....|....*....|....*.
gi 373219514 102 AALNALKSVPCVDKQKLGAFGFCIGG 127
Cdd:PRK05077 251 AVLNALPNVPWVDHTRVAAFGFRFGA 276
 
Name Accession Description Interval E-value
DLH COG0412
Dienelactone hydrolase [Secondary metabolites biosynthesis, transport and catabolism];
5-241 6.86e-51

Dienelactone hydrolase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 440181 [Multi-domain]  Cd Length: 226  Bit Score: 165.52  E-value: 6.86e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373219514   5 QTIDYEDADGNLFSGELYKPssDNSTKHPGVLIFPAFRGVSKLEIARAKLLAEeHGYVALVADIYGKGIRCTDISSAVTL 84
Cdd:COG0412    4 ETVTIPTPDGVTLPGYLARP--AGGGPRPGVVVLHEIFGLNPHIRDVARRLAA-AGYVVLAPDLYGRGGPGDDPDEARAL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373219514  85 LRPMTSDRngkLKPRLEAALNALKSVPCVDKQKLGAFGFCIGGLCSLDCARyRFDGIRAVISFHGTLTPIEGIPLEQLDD 164
Cdd:COG0412   81 MGALDPEL---LAADLRAALDWLKAQPEVDAGRVGVVGFCFGGGLALLAAA-RGPDLAAAVSFYGGLPADDLLDLAARIK 156
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 373219514 165 IFIQVHHGDADAHVSKVTVDAFHEEMRARNSDFVFISHGKAMHSFTDPESAeiapsgvGYDANADKRSWKATLEFLK 241
Cdd:COG0412  157 APVLLLYGEKDPLVPPEQVAALEAALAAAGVDVELHVYPGAGHGFTNPGRP-------RYDPAAAEDAWQRTLAFLA 226
DLH pfam01738
Dienelactone hydrolase family;
31-242 8.41e-45

Dienelactone hydrolase family;


Pssm-ID: 396343 [Multi-domain]  Cd Length: 213  Bit Score: 149.42  E-value: 8.41e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373219514   31 KHPGVLIFPAFRGVSK--LEIARAklLAEEhGYVALVADIYGKGIRCTDISSAVTLLRPMTSDRN-GKLKPRLEAALNAL 107
Cdd:pfam01738  11 PWPVVVVFQEIFGVNDniREIADR--LADE-GYVALAPDLYFRQGDPNDEADAARAMFELVSKRVmEKVLDDLEAAVNYL 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373219514  108 KSVPCVDKQKLGAFGFCIGGLCSLDCARyRFDGIRAVISFHGTLTPiegIPLEQLDDIF--IQVHHGDADAHVSKVTVDA 185
Cdd:pfam01738  88 KSQPEVSPKKVGVVGYCMGGALAVLLAA-KGPLVDAAVGFYGVGPE---PPLIEAPDIKapILFHFGEEDHFVPADSREL 163
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 373219514  186 FHEEMRARNSDFVFISHGKAMHSFTdpesaeiAPSGVGYDANADKRSWKATLEFLKE 242
Cdd:pfam01738 164 IEEALKAANVDHQIHSYPGAGHAFA-------NDSRPSYNAAAAEDAWERTLEFFKQ 213
DAP2 COG1506
Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];
9-242 7.06e-10

Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];


Pssm-ID: 441115 [Multi-domain]  Cd Length: 234  Bit Score: 57.33  E-value: 7.06e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373219514   9 YEDADGNLFSGELYKPssDNSTKHPGVLIFPAFRGVSKLE-IARAKLLAEeHGYVALVADIYGKGirctdiSSAVTLLRP 87
Cdd:COG1506    2 FKSADGTTLPGWLYLP--ADGKKYPVVVYVHGGPGSRDDSfLPLAQALAS-RGYAVLAPDYRGYG------ESAGDWGGD 72
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373219514  88 MTSDrngklkprLEAALNALKSVPCVDKQKLGAFGFCIGGLCSLDCARYRFDGIRAVISFHG-------------TLTPI 154
Cdd:COG1506   73 EVDD--------VLAAIDYLAARPYVDPDRIGIYGHSYGGYMALLAAARHPDRFKAAVALAGvsdlrsyygttreYTERL 144
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373219514 155 EGIPLEQLDDIF--------------IQVHHGDADAHVSKVTVDAFHEEMRARNSDFVFISHGKAMHSFTDPEsaeiaps 220
Cdd:COG1506  145 MGGPWEDPEAYAarsplayadklktpLLLIHGEADDRVPPEQAERLYEALKKAGKPVELLVYPGEGHGFSGAG------- 217
                        250       260
                 ....*....|....*....|..
gi 373219514 221 gvgydanaDKRSWKATLEFLKE 242
Cdd:COG1506  218 --------APDYLERILDFLDR 231
YpfH COG0400
Predicted esterase [General function prediction only];
98-218 1.27e-03

Predicted esterase [General function prediction only];


Pssm-ID: 440169 [Multi-domain]  Cd Length: 200  Bit Score: 38.73  E-value: 1.27e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373219514  98 PRLEAALNALKSVPCVDKQKLGAFGFCIGGLCSLDCARYRFDGIRAVISFHGTLTPIEGIPLEQLD----DIFIqvHHGD 173
Cdd:COG0400   71 EALAAFIDELEARYGIDPERIVLAGFSQGAAMALSLALRRPELLAGVVALSGYLPGEEALPAPEAAlagtPVFL--AHGT 148
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 373219514 174 ADAHVSKVTVDAFHEEMRARNSDFVFISHgKAMHSFTDPESAEIA 218
Cdd:COG0400  149 QDPVIPVERAREAAEALEAAGADVTYREY-PGGHEISPEELADAR 192
FrsA-like pfam06500
Esterase FrsA-like; The FrsA-like family includes FrsA, an esterase found to have the alpha ...
101-146 3.95e-03

Esterase FrsA-like; The FrsA-like family includes FrsA, an esterase found to have the alpha/beta-hydrolase fold. t also includes the hydrolytic polyketide shortening protein Ayg1 from fungi, 2,6-dihydropseudooxynicotine hydrolase from Paenarthrobacter nicotinovorans and Fus2 from Gibberella species. The enzyme 2,6-dihydroxy-pseudo-oxynicotine hydrolase is involved in the nicotine-degradation pathway of Arthrobacter nicotinovorans. Fus2 is part of the gene cluster that mediates the biosynthesis of the mycotoxin fusarin C. Fus2 catalyzes closure of the 2-pyrrolidone ring of the intermediate 20-hydroxy-prefusarin to form another intermediate, 20-hydroxy-fusarin, which is then oxidized by Fus8.


Pssm-ID: 428978 [Multi-domain]  Cd Length: 414  Bit Score: 37.93  E-value: 3.95e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 373219514  101 EAALNALKSVPCVDKQKLGAFGFCIGGLCSLDCARYRFDGIRAVIS 146
Cdd:pfam06500 250 QAVLNALADVPWVDHTRVGLFGFRFGANVAVRLAYLESPRVKAVAC 295
frsA PRK05077
esterase FrsA;
102-127 6.42e-03

esterase FrsA;


Pssm-ID: 235337  Cd Length: 414  Bit Score: 37.20  E-value: 6.42e-03
                         10        20
                 ....*....|....*....|....*.
gi 373219514 102 AALNALKSVPCVDKQKLGAFGFCIGG 127
Cdd:PRK05077 251 AVLNALPNVPWVDHTRVAAFGFRFGA 276
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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