Protein Kinases, catalytic domain; The protein kinase superfamily is mainly composed of the catalytic domains of serine/threonine-specific and tyrosine-specific protein kinases. It also includes RIO kinases, which are atypical serine protein kinases, aminoglycoside phosphotransferases, and choline kinases. These proteins catalyze the transfer of the gamma-phosphoryl group from ATP to hydroxyl groups in specific substrates such as serine, threonine, or tyrosine residues of proteins.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351063033 357 VHLIQQTFYCISDLHKIGYTHLDIRPSSFSLLRN--NKAVVVLNSFfnsetrqNISRNIRTTKHNGLQPlyvqqarhARN 434
Cdd:cd14017  100 LRLGIQILKAIEDIHEVGFLHRDVKPSNFAIGRGpsDERTVYILDF-------GLARQYTNKDGEVERP--------PRN 164

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 351063033 435 K-----SEReplpknvintYMSRRQHFRLARGPADDYESWFYICARFITlKTFEWHDEEDHIVAATMK 497
Cdd:cd14017  165 AagfrgTVR----------YASVNAHRNKEQGRRDDLWSWFYMLIEFVT-GQLPWRKLKDKEEVGKMK 221

Catalytic domain of the Serine/Threonine protein kinase, Tau-Tubulin Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. TTBK is a neuron-specific kinase that phosphorylates the microtubule-associated protein tau and promotes its aggregation. Higher vertebrates contain two TTBK proteins, TTBK1 and TTBK2, both of which have been implicated in neurodegeneration. TTBK1 has been linked to Alzheimer's disease (AD) while TTBK2 is associated with spinocerebellar ataxia type 11 (SCA11). Both AD and SCA11 patients show the presence of neurofibrillary tangles in the brain. The Drosophila TTBK homolog, Asator, is an essential protein that localizes to the mitotic spindle during mitosis and may be involved in regulating microtubule dynamics and function. The TTBK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351063033 357 VHLIQQTFYCISDLHKIGYTHLDIRPSSFSLLRN--NKAVVVLNSFfnsetrqNISRNIRTTKHNGLQPlyvqqarhARN 434
Cdd:cd14017  100 LRLGIQILKAIEDIHEVGFLHRDVKPSNFAIGRGpsDERTVYILDF-------GLARQYTNKDGEVERP--------PRN 164

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 351063033 435 K-----SEReplpknvintYMSRRQHFRLARGPADDYESWFYICARFITlKTFEWHDEEDHIVAATMK 497
Cdd:cd14017  165 AagfrgTVR----------YASVNAHRNKEQGRRDDLWSWFYMLIEFVT-GQLPWRKLKDKEEVGKMK 221

Catalytic domain of the Serine/Threonine protein kinase, Tau-Tubulin Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. TTBK is a neuron-specific kinase that phosphorylates the microtubule-associated protein tau and promotes its aggregation. Higher vertebrates contain two TTBK proteins, TTBK1 and TTBK2, both of which have been implicated in neurodegeneration. TTBK1 has been linked to Alzheimer's disease (AD) while TTBK2 is associated with spinocerebellar ataxia type 11 (SCA11). Both AD and SCA11 patients show the presence of neurofibrillary tangles in the brain. The Drosophila TTBK homolog, Asator, is an essential protein that localizes to the mitotic spindle during mitosis and may be involved in regulating microtubule dynamics and function. The TTBK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351063033 357 VHLIQQTFYCISDLHKIGYTHLDIRPSSFSLLRN--NKAVVVLNSFfnsetrqNISRNIRTTKHNGLQPlyvqqarhARN 434
Cdd:cd14017  100 LRLGIQILKAIEDIHEVGFLHRDVKPSNFAIGRGpsDERTVYILDF-------GLARQYTNKDGEVERP--------PRN 164

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 351063033 435 K-----SEReplpknvintYMSRRQHFRLARGPADDYESWFYICARFITlKTFEWHDEEDHIVAATMK 497
Cdd:cd14017  165 AagfrgTVR----------YASVNAHRNKEQGRRDDLWSWFYMLIEFVT-GQLPWRKLKDKEEVGKMK 221