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Conserved domains on  [gi|351063931|emb|CCD72184|]
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Nucleoside phosphorylase domain-containing protein [Caenorhabditis elegans]

Protein Classification

nucleoside phosphorylase-I family protein( domain architecture ID 762)

nucleoside phosphorylase-I family protein

CATH:  3.40.50.1580
PubMed:  11743878
SCOP:  4000573

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MtnN super family cl41794
Nucleoside phosphorylase/nucleosidase, includes 5'-methylthioadenosine/S-adenosylhomocysteine ...
 136-256 3.64e-07

Nucleoside phosphorylase/nucleosidase, includes 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase MtnN and futalosine hydrolase MqnB [Nucleotide transport and metabolism, Coenzyme transport and metabolism]; Nucleoside phosphorylase/nucleosidase, includes 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase MtnN and futalosine hydrolase MqnB is part of the Pathway/BioSystem: Menaquinone biosynthesis


The actual alignment was detected with superfamily member COG0775:

Pssm-ID: 440538  Cd Length: 231  Bit Score: 51.06  E-value: 3.64e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351063931 136 TVAIISCLFVEKQAIDALIEESSTIHKYKsggdsNVYTLGRIGAHRVVatkLALIGdsreaI--TSAGSITTRLLGNFqN 213
Cdd:COG0775    2 TIGIIGAMEEEVAALLEALEDKKEVQIAG-----FTFYLGTLGGKEVV---LVNSG-----IgkVNAATATTLLIARF-R 67

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 351063931 214 IEHVFIVGVAGAVphftDATLHarLGDVIVSasrpHQYVYaHD 256
Cdd:COG0775   68 PDAVINTGVAGGL----DPDLK--IGDVVLA----TEVVQ-HD 99
 
Name Accession Description Interval E-value
MtnN COG0775
Nucleoside phosphorylase/nucleosidase, includes 5'-methylthioadenosine/S-adenosylhomocysteine ...
 136-256 3.64e-07

Nucleoside phosphorylase/nucleosidase, includes 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase MtnN and futalosine hydrolase MqnB [Nucleotide transport and metabolism, Coenzyme transport and metabolism]; Nucleoside phosphorylase/nucleosidase, includes 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase MtnN and futalosine hydrolase MqnB is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440538  Cd Length: 231  Bit Score: 51.06  E-value: 3.64e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351063931 136 TVAIISCLFVEKQAIDALIEESSTIHKYKsggdsNVYTLGRIGAHRVVatkLALIGdsreaI--TSAGSITTRLLGNFqN 213
Cdd:COG0775    2 TIGIIGAMEEEVAALLEALEDKKEVQIAG-----FTFYLGTLGGKEVV---LVNSG-----IgkVNAATATTLLIARF-R 67

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 351063931 214 IEHVFIVGVAGAVphftDATLHarLGDVIVSasrpHQYVYaHD 256
Cdd:COG0775   68 PDAVINTGVAGGL----DPDLK--IGDVVLA----TEVVQ-HD 99
MTAN cd09008
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidases; This subfamily includes both ...
 137-284 8.94e-06

5'-methylthioadenosine/S-adenosylhomocysteine nucleosidases; This subfamily includes both bacterial and plant 5'-methylthioadenosine/S-adenosylhomocysteine (MTA/SAH) nucleosidases (MTANs): bacterial MTANs show comparable efficiency in hydrolyzing MTA and SAH, while plant enzymes are highly specific for MTA and are unable to metabolize SAH or show significantly reduced activity towards SAH. MTAN is involved in methionine and S-adenosyl-methionine recycling, polyamine biosynthesis, and bacterial quorum sensing. This subfamily belongs to the nucleoside phosphorylase-I (NP-I) family, whose members accept a range of purine nucleosides as well as the pyrimidine nucleoside uridine. The NP-1 family includes phosphorolytic nucleosidases, such as purine nucleoside phosphorylase (PNPs, EC. 2.4.2.1), uridine phosphorylase (UP, EC 2.4.2.3), and 5'-deoxy-5'-methylthioadenosine phosphorylase (MTAP, EC 2.4.2.28), and hydrolytic nucleosidases, such as AMP nucleosidase (AMN, EC 3.2.2.4), and 5'-methylthioadenosine/S-adenosylhomocysteine (MTA/SAH) nucleosidase (MTAN, EC 3.2.2.16). The NP-I family is distinct from nucleoside phosphorylase-II, which belongs to a different structural family.


Pssm-ID: 350159  Cd Length: 222  Bit Score: 46.72  E-value: 8.94e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351063931 137 VAIISCLFVEkqaIDALIEESSTIHKYKSGGdsNVYTLGRIGAHRVVATKlaligdSREAITSAGSITTRLLGNFqNIEH 216
Cdd:cd09008    1 IGIIGAMEEE---IAPLLELLENVEEETIAG--RTFYEGTLGGKEVVLVQ------SGIGKVNAAIATQLLIDRF-KPDA 68

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 351063931 217 VFIVGVAGAVphftDATLHarLGDVIVSASrphqyVYAHDL---LFNRQTEQITGFAIRnWDADDKTIEKI 284
Cdd:cd09008   69 IINTGVAGGL----DPDLK--IGDVVIATK-----VVYHDVdatAFGYEGGQPPGMPAY-FPADPELLELA 127
 
Name Accession Description Interval E-value
MtnN COG0775
Nucleoside phosphorylase/nucleosidase, includes 5'-methylthioadenosine/S-adenosylhomocysteine ...
 136-256 3.64e-07

Nucleoside phosphorylase/nucleosidase, includes 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase MtnN and futalosine hydrolase MqnB [Nucleotide transport and metabolism, Coenzyme transport and metabolism]; Nucleoside phosphorylase/nucleosidase, includes 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase MtnN and futalosine hydrolase MqnB is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440538  Cd Length: 231  Bit Score: 51.06  E-value: 3.64e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351063931 136 TVAIISCLFVEKQAIDALIEESSTIHKYKsggdsNVYTLGRIGAHRVVatkLALIGdsreaI--TSAGSITTRLLGNFqN 213
Cdd:COG0775    2 TIGIIGAMEEEVAALLEALEDKKEVQIAG-----FTFYLGTLGGKEVV---LVNSG-----IgkVNAATATTLLIARF-R 67

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 351063931 214 IEHVFIVGVAGAVphftDATLHarLGDVIVSasrpHQYVYaHD 256
Cdd:COG0775   68 PDAVINTGVAGGL----DPDLK--IGDVVLA----TEVVQ-HD 99
MTAN cd09008
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidases; This subfamily includes both ...
 137-284 8.94e-06

5'-methylthioadenosine/S-adenosylhomocysteine nucleosidases; This subfamily includes both bacterial and plant 5'-methylthioadenosine/S-adenosylhomocysteine (MTA/SAH) nucleosidases (MTANs): bacterial MTANs show comparable efficiency in hydrolyzing MTA and SAH, while plant enzymes are highly specific for MTA and are unable to metabolize SAH or show significantly reduced activity towards SAH. MTAN is involved in methionine and S-adenosyl-methionine recycling, polyamine biosynthesis, and bacterial quorum sensing. This subfamily belongs to the nucleoside phosphorylase-I (NP-I) family, whose members accept a range of purine nucleosides as well as the pyrimidine nucleoside uridine. The NP-1 family includes phosphorolytic nucleosidases, such as purine nucleoside phosphorylase (PNPs, EC. 2.4.2.1), uridine phosphorylase (UP, EC 2.4.2.3), and 5'-deoxy-5'-methylthioadenosine phosphorylase (MTAP, EC 2.4.2.28), and hydrolytic nucleosidases, such as AMP nucleosidase (AMN, EC 3.2.2.4), and 5'-methylthioadenosine/S-adenosylhomocysteine (MTA/SAH) nucleosidase (MTAN, EC 3.2.2.16). The NP-I family is distinct from nucleoside phosphorylase-II, which belongs to a different structural family.


Pssm-ID: 350159  Cd Length: 222  Bit Score: 46.72  E-value: 8.94e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351063931 137 VAIISCLFVEkqaIDALIEESSTIHKYKSGGdsNVYTLGRIGAHRVVATKlaligdSREAITSAGSITTRLLGNFqNIEH 216
Cdd:cd09008    1 IGIIGAMEEE---IAPLLELLENVEEETIAG--RTFYEGTLGGKEVVLVQ------SGIGKVNAAIATQLLIDRF-KPDA 68

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 351063931 217 VFIVGVAGAVphftDATLHarLGDVIVSASrphqyVYAHDL---LFNRQTEQITGFAIRnWDADDKTIEKI 284
Cdd:cd09008   69 IINTGVAGGL----DPDLK--IGDVVIATK-----VVYHDVdatAFGYEGGQPPGMPAY-FPADPELLELA 127
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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