|
Name |
Accession |
Description |
Interval |
E-value |
| HrpA |
COG1643 |
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]; |
95-703 |
9.09e-175 |
|
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];
Pssm-ID: 441249 [Multi-domain] Cd Length: 836 Bit Score: 521.56 E-value: 9.09e-175
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064569 95 TIIIVGETGCGKSTQVPQFLLEAGWAADGRqIVITQPRRVAVVTLATRVAEEKDCILGHDVGYTVRFDDVSDKDTKVKFM 174
Cdd:COG1643 28 VVVLAAPPGAGKTTQLPLALLELGWGAGGR-IGMLEPRRLAARAAAERMAEELGEPVGETVGYRVRFEDKVSAATRIEVV 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064569 175 TDGLLLREILADPLLSKYSIIMIDEAHERSCNTDILLGLLRKIIQ-IRNDLRIIVSSATLDAELFKDFFemnetgnsdkD 253
Cdd:COG1643 107 TEGILLRELQRDPELEGVDTVIFDEFHERSLNADLLLALLLDLQPaLRPDLKLLVMSATLDAERFARLL----------G 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064569 254 TAGIISVEGRTHPVAVHHT--KTSVPDYCQSAVDTVINIHKhENPGDILVFLTGQDEVEDVCEKLRELAgnLKNCDrlwV 331
Cdd:COG1643 177 DAPVIESSGRTYPVEVRYRplPADERDLEDAVADAVREALA-EEPGDILVFLPGEREIRRTAEALRGRL--PPDTE---I 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064569 332 VPCYGALPAREQMKAFDSTPHGTRKVVVATNIAEASITIPGICYVIDTGYVKlRAQ-HAANGVETLMRVTVSKASAEQRA 410
Cdd:COG1643 251 LPLYGRLSAAEQDRAFAPAPHGRRRIVLATNIAETSLTVPGIRYVIDSGLAR-IPRyDPRSGVTRLPTERISQASANQRA 329
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064569 411 GRAGRIRPGKCYRLYPESEFERFAEGTVPEIQRCQMASTILQLKALGVQNVHRFHYLSPPPSwAMIN-GLELLYALGAID 489
Cdd:COG1643 330 GRAGRLAPGICYRLWSEEDFARRPAFTDPEILRADLASLILELAAWGLGDPEDLPFLDPPPA-RAIAdARALLQELGALD 408
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064569 490 ETSQLTsPLGLQMAEFPLPPMHSKCLLKSAEFGCSTEMVTIVAMMQIQDvfitPYRQRHQADVirkkfaveegdhMTMLN 569
Cdd:COG1643 409 ADGRLT-PLGRALARLPLDPRLARMLLAAAELGCLREAAILAALLSERD----PRRGAAGSDL------------LARLN 471
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064569 570 VFTKFVENGRskkwcsdHFVNYRGLMRADNVRSQLVRLLKrfeiEKVSSRGLIncSENIRQCLVTGFFSQAAQY-----H 644
Cdd:COG1643 472 LWRRLREQQR-------EFLSYLRLREWRDLARQLRRLLG----EGANEEPAD--YEAIGLLLALAYPDRIARRrgeggR 538
|
570 580 590 600 610 620
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 351064569 645 Y-----TGkymtvkesfpFNMYKGSSiMFKKdypKWVIFTEVMQDS----IRDVTVIEPEWLYELAPH 703
Cdd:COG1643 539 YllargRG----------AALFPGSP-LAKK---EWLVAAELVGGAaearIRLAAPIDPEWLEELAAH 592
|
|
| DEAH_box_HrpA |
TIGR01967 |
RNA helicase HrpA; This model represents HrpA, one of two related but uncharacterized DEAH-box ... |
77-703 |
6.87e-136 |
|
RNA helicase HrpA; This model represents HrpA, one of two related but uncharacterized DEAH-box ATP-dependent helicases in many Proteobacteria and a few high-GC Gram-positive bacteria. HrpA is about 1300 amino acids long, while its paralog HrpB, also uncharacterized, is about 800 amino acids long. Related characterized eukarotic proteins are RNA helicases associated with pre-mRNA processing. The HrpA/B homolog from Borrelia is 500 amino acids shorter but appears to be derived from HrpA rather than HrpB. [Unknown function, Enzymes of unknown specificity]
Pssm-ID: 273900 [Multi-domain] Cd Length: 1283 Bit Score: 432.27 E-value: 6.87e-136
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064569 77 LPIFKNRGHILYMCERYRTIIIVGETGCGKSTQVPQFLLEAGWAADGrQIVITQPRRVAVVTLATRVAEEKDCILGHDVG 156
Cdd:TIGR01967 66 LPVSAKREDIAEAIAENQVVIIAGETGSGKTTQLPKICLELGRGSHG-LIGHTQPRRLAARTVAQRIAEELGTPLGEKVG 144
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064569 157 YTVRFDDVSDKDTKVKFMTDGLLLREILADPLLSKYSIIMIDEAHERSCNTDILLGLLRKIIQIRNDLRIIVSSATLDAE 236
Cdd:TIGR01967 145 YKVRFHDQVSSNTLVKLMTDGILLAETQQDRFLSRYDTIIIDEAHERSLNIDFLLGYLKQLLPRRPDLKIIITSATIDPE 224
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064569 237 LFKDFFemnetgnsdkDTAGIISVEGRTHPVAVHHTKTSVP------DYCQSAVDTVINIHKHEnPGDILVFLTGQDEVE 310
Cdd:TIGR01967 225 RFSRHF----------NNAPIIEVSGRTYPVEVRYRPLVEEqedddlDQLEAILDAVDELFAEG-PGDILIFLPGEREIR 293
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064569 311 DVCEKLRELagNLKNCDrlwVVPCYGALPAREQMKAFDstPHGTRKVVVATNIAEASITIPGICYVIDTGYVKLRAQHAA 390
Cdd:TIGR01967 294 DAAEILRKR--NLRHTE---ILPLYARLSNKEQQRVFQ--PHSGRRIVLATNVAETSLTVPGIHYVIDTGTARISRYSYR 366
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064569 391 NGVETLMRVTVSKASAEQRAGRAGRIRPGKCYRLYPESEFERFAEGTVPEIQRCQMASTILQLKALGVQNVHRFHYLSPP 470
Cdd:TIGR01967 367 TKVQRLPIEPISQASANQRKGRCGRVAPGICIRLYSEEDFNSRPEFTDPEILRTNLASVILQMLALRLGDIAAFPFIEAP 446
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064569 471 PSWAMINGLELLYALGAIDE---TSQLTsPLGLQMAEFPLPPMHSKCLLKSAEFGCSTEMVTIVAMMQIQDVFITPYRQR 547
Cdd:TIGR01967 447 DPRAIRDGFRLLEELGALDDdeaEPQLT-PIGRQLAQLPVDPRLARMLLEAHRLGCLQEVLIIASALSIQDPRERPMEKQ 525
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064569 548 HQADVIRKKFAVEEGDHMTMLNVFTKFVE--NGRSK----KWCSDHFVNYRGLMRADNVRSQLVRLLKRFEIEKVSSRGl 621
Cdd:TIGR01967 526 QAADQAHARFKDPRSDFLSRVNLWRHIEEqrQALSAnqfrNACRKQYLNYLRVREWQDIYRQLTQVVKELGLKLNEEPA- 604
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064569 622 inCSENIRQCLVTGFFSQAAQYHYTGKYMTVKESfPFNMYKGSSiMFKKDyPKWVIFTEVMQDS---IRDVTVIEPEWLY 698
Cdd:TIGR01967 605 --DYDAIHKALLSGLLSQIGMKDEKHEYDGARGR-KFHIFPGSP-LFKKP-PKWVMAAELVETSklyARLVAKIEPEWVE 679
|
....*
gi 351064569 699 ELAPH 703
Cdd:TIGR01967 680 PVAGH 684
|
|
| PRK11131 |
PRK11131 |
ATP-dependent RNA helicase HrpA; Provisional |
77-703 |
3.29e-133 |
|
ATP-dependent RNA helicase HrpA; Provisional
Pssm-ID: 182986 [Multi-domain] Cd Length: 1294 Bit Score: 425.24 E-value: 3.29e-133
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064569 77 LPIFKNRGHILYMCERYRTIIIVGETGCGKSTQVPQFLLEAGWAADGrQIVITQPRRVAVVTLATRVAEEKDCILGHDVG 156
Cdd:PRK11131 73 LPVSQKKQDILEAIRDHQVVIVAGETGSGKTTQLPKICLELGRGVKG-LIGHTQPRRLAARTVANRIAEELETELGGCVG 151
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064569 157 YTVRFDD-VSDkDTKVKFMTDGLLLREILADPLLSKYSIIMIDEAHERSCNTDILLGLLRKIIQIRNDLRIIVSSATLDA 235
Cdd:PRK11131 152 YKVRFNDqVSD-NTMVKLMTDGILLAEIQQDRLLMQYDTIIIDEAHERSLNIDFILGYLKELLPRRPDLKVIITSATIDP 230
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064569 236 ELFKDFFemnetgnsdkDTAGIISVEGRTHPVAVHH------TKTSVPDYCQSAVDTVINIhKHENPGDILVFLTGQDEV 309
Cdd:PRK11131 231 ERFSRHF----------NNAPIIEVSGRTYPVEVRYrpiveeADDTERDQLQAIFDAVDEL-GREGPGDILIFMSGEREI 299
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064569 310 EDVCEKLRELagNLKNCDrlwVVPCYGALPAREQMKAFDstPHGTRKVVVATNIAEASITIPGICYVIDTGYVKLRAQHA 389
Cdd:PRK11131 300 RDTADALNKL--NLRHTE---ILPLYARLSNSEQNRVFQ--SHSGRRIVLATNVAETSLTVPGIKYVIDPGTARISRYSY 372
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064569 390 ANGVETLMRVTVSKASAEQRAGRAGRIRPGKCYRLYPESEFERFAEGTVPEIQRCQMASTILQLKALGVQNVHRFHYLSP 469
Cdd:PRK11131 373 RTKVQRLPIEPISQASANQRKGRCGRVSEGICIRLYSEDDFLSRPEFTDPEILRTNLASVILQMTALGLGDIAAFPFVEA 452
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064569 470 PPSWAMINGLELLYALGAIDETS-----QLTsPLGLQMAEFPLPPMHSKCLLKSAEFGCSTEMVTIVAMMQIQDVFITPY 544
Cdd:PRK11131 453 PDKRNIQDGVRLLEELGAITTDEqasayKLT-PLGRQLAQLPVDPRLARMVLEAQKHGCVREVMIITSALSIQDPRERPM 531
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064569 545 RQRHQADVIRKKFAVEEGDHMTMLNVFTKFVENGRS------KKWCSDHFVNYRGLMRADNVRSQLVRLLKRFEI----E 614
Cdd:PRK11131 532 DKQQASDEKHRRFADKESDFLAFVNLWNYLQEQQKAlssnqfRRLCRTDYLNYLRVREWQDIYTQLRQVVKELGIpvnsE 611
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064569 615 KVSSRGlINCSenirqcLVTGFFSQAAQ-----YHYTGkymtvKESFPFNMYKGSSImFKKDyPKWVIFTEVMQDSI--- 686
Cdd:PRK11131 612 PAEYRE-IHTA------LLTGLLSHIGMkdaekQEYTG-----ARNARFSIFPGSGL-FKKP-PKWVMVAELVETSRlwg 677
|
650
....*....|....*..
gi 351064569 687 RDVTVIEPEWLYELAPH 703
Cdd:PRK11131 678 RIAARIEPEWIEPLAQH 694
|
|
| DEXHc_DHX35 |
cd17980 |
DEXH-box helicase domain of DEAH-box helicase 35; DHX35 plays a role in colorectal cancers and ... |
77-260 |
1.26e-119 |
|
DEXH-box helicase domain of DEAH-box helicase 35; DHX35 plays a role in colorectal cancers and seems to be associated with risk to thyroid cancers. It also has been shown to positively regulate poxviruses, such as Myxoma virus. DEAH-box helicase 35 (DHX35) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350738 [Multi-domain] Cd Length: 185 Bit Score: 356.01 E-value: 1.26e-119
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064569 77 LPIFKNRGHILYMCERYRTIIIVGETGCGKSTQVPQFLLEAGWAADGRQIVITQPRRVAVVTLATRVAEEKDCILGHDVG 156
Cdd:cd17980 1 LPVFKLRNHILYLVENYQTIVIVGETGCGKSTQIPQYLAEAGWTAGGRVVGCTQPRRVAAVTVAGRVAEEMGAVLGHEVG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064569 157 YTVRFDDVSDKD-TKVKFMTDGLLLREILADPLLSKYSIIMIDEAHERSCNTDILLGLLRKIIQIRNDLRIIVSSATLDA 235
Cdd:cd17980 81 YCIRFDDCTDPQaTRIKFLTDGMLVREMMLDPLLTKYSVIMLDEAHERTLYTDILIGLLKKIQKKRGDLRLIVASATLDA 160
|
170 180
....*....|....*....|....*
gi 351064569 236 ELFKDFFEMNETGNSDKDTAGIISV 260
Cdd:cd17980 161 EKFRDFFNQNETNDPSKDTATILSV 185
|
|
| DEAH_box_HrpB |
TIGR01970 |
ATP-dependent helicase HrpB; This model represents HrpB, one of two related but ... |
96-538 |
1.04e-91 |
|
ATP-dependent helicase HrpB; This model represents HrpB, one of two related but uncharacterized DEAH-box ATP-dependent helicases in many Proteobacteria, but also in a few species of other lineages. The member from Rhizobium meliloti has been designated HelO. HrpB is typically about 800 residues in length, while its paralog HrpA (TIGR01967), also uncharacterized, is about 1300 amino acids long. Related characterized eukarotic proteins are RNA helicases associated with pre-mRNA processing. [Unknown function, Enzymes of unknown specificity]
Pssm-ID: 273901 [Multi-domain] Cd Length: 819 Bit Score: 304.00 E-value: 1.04e-91
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064569 96 IIIVGETGCGKSTQVPQFLLEAGWAadGRQIVITQPRRVAVVTLATRVAEEKDCILGHDVGYTVRFDDVSDKDTKVKFMT 175
Cdd:TIGR01970 20 VVLEAPPGAGKSTAVPLALLDAPGI--GGKIIMLEPRRLAARSAAQRLASQLGEAVGQTVGYRVRGENKVSRRTRLEVVT 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064569 176 DGLLLREILADPLLSKYSIIMIDEAHERSCNTDILLGLLRKI-IQIRNDLRIIVSSATLDAELFKDFFemnetgnsdkDT 254
Cdd:TIGR01970 98 EGILTRMIQDDPELDGVGALIFDEFHERSLDADLGLALALDVqSSLREDLKILAMSATLDGERLSSLL----------PD 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064569 255 AGIISVEGRTHPVAVHHTKTSVPDYCQSAV-DTVINIHKHEnPGDILVFLTGQDEVEDVCEKLRELAGNlkncdRLWVVP 333
Cdd:TIGR01970 168 APVVESEGRSFPVEIRYLPLRGDQRLEDAVsRAVEHALASE-TGSILVFLPGQAEIRRVQEQLAERLDS-----DVLICP 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064569 334 CYGALPAREQMKAFDSTPHGTRKVVVATNIAEASITIPGICYVIDTGYVKLRAQHAANGVETLMRVTVSKASAEQRAGRA 413
Cdd:TIGR01970 242 LYGELSLAAQDRAIKPDPQGRRKVVLATNIAETSLTIEGIRVVIDSGLARVARFDPKTGITRLETVRISQASATQRAGRA 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064569 414 GRIRPGKCYRLYPESEFERFAEGTVPEIQRCQMASTILQLKALGVQNVHRFHYLSPPPSWAMINGLELLYALGAIDETSQ 493
Cdd:TIGR01970 322 GRLEPGVCYRLWSEEQHQRLPAQDEPEILQADLSGLALELAQWGAKDPSDLRWLDAPPSVALAAARQLLQRLGALDAQGR 401
|
410 420 430 440
....*....|....*....|....*....|....*....|....*
gi 351064569 494 LTSpLGLQMAEFPLPPMHSKCLLKSAEFGCSTEMVTIVAMMQIQD 538
Cdd:TIGR01970 402 LTA-HGKAMAALGCHPRLAAMLLSAHSTGLAALACDLAALLEERG 445
|
|
| PRK11664 |
PRK11664 |
ATP-dependent RNA helicase HrpB; Provisional |
102-522 |
1.12e-83 |
|
ATP-dependent RNA helicase HrpB; Provisional
Pssm-ID: 236950 [Multi-domain] Cd Length: 812 Bit Score: 282.20 E-value: 1.12e-83
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064569 102 TGCGKSTQVP-QFLLEAGWaaDGRqIVITQPRRVAVVTLATRVAE---EKdciLGHDVGYTVRFDDVSDKDTKVKFMTDG 177
Cdd:PRK11664 29 TGAGKSTWLPlQLLQHGGI--NGK-IIMLEPRRLAARNVAQRLAEqlgEK---PGETVGYRMRAESKVGPNTRLEVVTEG 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064569 178 LLLREILADPLLSKYSIIMIDEAHERSCNTDILLGLLRKIIQ-IRNDLRIIVSSATLDAE----LFKDffemnetgnsdk 252
Cdd:PRK11664 103 ILTRMIQRDPELSGVGLVILDEFHERSLQADLALALLLDVQQgLRDDLKLLIMSATLDNDrlqqLLPD------------ 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064569 253 dtAGIISVEGRTHPVAVHHTKTSVPDYCQSAVDTVINIHKHENPGDILVFLTGQDEVEDVCEKLRE-LAGNLKNCdrlwv 331
Cdd:PRK11664 171 --APVIVSEGRSFPVERRYQPLPAHQRFDEAVARATAELLRQESGSLLLFLPGVGEIQRVQEQLASrVASDVLLC----- 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064569 332 vPCYGALPAREQMKAFDSTPHGTRKVVVATNIAEASITIPGICYVIDTGYVKLRAQHAANGVETLMRVTVSKASAEQRAG 411
Cdd:PRK11664 244 -PLYGALSLAEQQKAILPAPAGRRKVVLATNIAETSLTIEGIRLVVDSGLERVARFDPKTGLTRLVTQRISQASMTQRAG 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064569 412 RAGRIRPGKCYRLYPESEFERFAEGTVPEIQRCQMASTILQLKALGVQNVHRFHYLSPPPSWAMINGLELLYALGAIDET 491
Cdd:PRK11664 323 RAGRLEPGICLHLYSKEQAERAAAQSEPEILHSDLSGLLLELLQWGCHDPAQLSWLDQPPAAALAAAKRLLQQLGALDGQ 402
|
410 420 430
....*....|....*....|....*....|.
gi 351064569 492 SQLTSpLGLQMAEFPLPPMHSKCLLKSAEFG 522
Cdd:PRK11664 403 GRLTA-RGRKMAALGNDPRLAAMLVAAKEDD 432
|
|
| DEXHc_RHA-like |
cd17917 |
DEXH-box helicase domain of DEAD-like helicase RHA family proteins; The RNA helicase A (RHA) ... |
94-260 |
1.23e-83 |
|
DEXH-box helicase domain of DEAD-like helicase RHA family proteins; The RNA helicase A (RHA) family includes RHA, also called DEAH-box helicase 9 (DHX9), DHX8, DHX15-16, DHX32-38, and many others. The RHA family belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438707 [Multi-domain] Cd Length: 159 Bit Score: 261.63 E-value: 1.23e-83
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064569 94 RTIIIVGETGCGKSTQVPQFLLEAGWAADGR-QIVITQPRRVAVVTLATRVAEEKDCILGHDVGYTVRFDDVSDKDTKVK 172
Cdd:cd17917 2 QVVVIVGETGSGKTTQVPQFLLEDGLAKGGKgRIVCTQPRRIAAISVAERVAEERGEKLGEEVGYQIRFESKTSSKTRIK 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064569 173 FMTDGLLLREILADPLLSKYSIIMIDEAHERSCNTDILLGLLRKIIQIRNDLRIIVSSATLDAELFKDFFemnetgnsdk 252
Cdd:cd17917 82 FCTDGILLRELLSDPLLSGYSHVILDEAHERSLDTDFLLGLLKDLLRKRPDLKVILMSATLDAEKFSSYF---------- 151
|
....*...
gi 351064569 253 DTAGIISV 260
Cdd:cd17917 152 GGAPVIHI 159
|
|
| DEXHc_DHX33 |
cd17978 |
DEXH-box helicase domain of DEAH-box helicase 33; DEAH-box helicase 33 (DHX33) stimulates RNA ... |
77-242 |
1.02e-75 |
|
DEXH-box helicase domain of DEAH-box helicase 33; DEAH-box helicase 33 (DHX33) stimulates RNA polymerase I transcription of the 47S precursor rRNA. DHX33 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438710 [Multi-domain] Cd Length: 178 Bit Score: 241.88 E-value: 1.02e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064569 77 LPIFKNRGHILYMCERYRTIIIVGETGCGKSTQVPQFLLEAGWAaDGRQIVITQPRRVAVVTLATRVAEEKDCILGHDVG 156
Cdd:cd17978 1 LPIYSARKRLLEELRKHDTVIIIGETGSGKTTQIPQYLYEAGFA-RGGMIGITQPRRVAAVSVAKRVAEEMGVELGQLVG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064569 157 YTVRFDDVSDKDTKVKFMTDGLLLREILADPLLSKYSIIMIDEAHERSCNTDILLGLLRKIIQIR-----NDLRIIVSSA 231
Cdd:cd17978 80 YSVRFDDVTSEETRIKYMTDGMLLREAIGDPLLSKYSVIILDEAHERTVHTDVLFGLVKSAQRRRkeqklSPLKVIIMSA 159
|
170
....*....|.
gi 351064569 232 TLDAELFKDFF 242
Cdd:cd17978 160 TLDADLFSEYF 170
|
|
| SF2_C_RHA |
cd18791 |
C-terminal helicase domain of the RNA helicase A (RHA) family helicases; The RNA helicase A ... |
265-425 |
2.43e-75 |
|
C-terminal helicase domain of the RNA helicase A (RHA) family helicases; The RNA helicase A (RHA) family includes RHA, also called DEAH-box helicase 9 (DHX9), DHX8, DHX15-16, DHX32-38, and many others. The RHA family members are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350178 [Multi-domain] Cd Length: 171 Bit Score: 240.51 E-value: 2.43e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064569 265 HPVAVHHTKT-----------SVPDYCQSAVDTVINIHKHENPGDILVFLTGQDEVEDVCEKLRELAgNLKNCDRLWVVP 333
Cdd:cd18791 1 FPVEVYYLEDilellgissekEDPDYVDAAVRLILQIHRTEEPGDILVFLPGQEEIERLCELLREEL-LSPDLGKLLVLP 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064569 334 CYGALPAREQMKAFDSTPHGTRKVVVATNIAEASITIPGICYVIDTGYVKLRAQHAANGVETLMRVTVSKASAEQRAGRA 413
Cdd:cd18791 80 LHSSLPPEEQQRVFEPPPPGVRKVVLATNIAETSITIPGVVYVIDSGLVKEKVYDPRTGLSSLVTVWISKASAEQRAGRA 159
|
170
....*....|..
gi 351064569 414 GRIRPGKCYRLY 425
Cdd:cd18791 160 GRTRPGKCYRLY 171
|
|
| DEXHc_DHX8 |
cd17971 |
DEXH-box helicase domain of DEAH-box helicase 8; DEAH-box helicase 8 (DHX8 ,also known as ... |
72-242 |
4.56e-67 |
|
DEXH-box helicase domain of DEAH-box helicase 8; DEAH-box helicase 8 (DHX8 ,also known as pre-mRNA-splicing factor ATP-dependent RNA helicase PRP22) acts late in the splicing of pre-mRNA and mediates the release of the spliced mRNA from spliceosomes. DHX8 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350729 [Multi-domain] Cd Length: 179 Bit Score: 218.89 E-value: 4.56e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064569 72 QQRIRLPIFKNRGHILYMCERYRTIIIVGETGCGKSTQVPQFLLEAGWAADGRqIVITQPRRVAVVTLATRVAEEKDCIL 151
Cdd:cd17971 1 EQRESLPIYKLKEQLIQAVHDNQILVVIGETGSGKTTQITQYLAEAGYTSRGK-IGCTQPRRVAAMSVAKRVAEEFGCCL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064569 152 GHDVGYTVRFDDVSDKDTKVKFMTDGLLLREILADPLLSKYSIIMIDEAHERSCNTDILLGLLRKIIQIRNDLRIIVSSA 231
Cdd:cd17971 80 GQEVGYTIRFEDCTSPETVIKYMTDGMLLRECLIDPDLSQYSVIMLDEAHERTIHTDVLFGLLKKTVQKRPDLKLIVTSA 159
|
170
....*....|.
gi 351064569 232 TLDAELFKDFF 242
Cdd:cd17971 160 TLDAVKFSQYF 170
|
|
| DEXHc_DHX16 |
cd17974 |
DEXH-box helicase domain of DEAH-box helicase 16; DEAH-box helicase 16 (DHX16) is probably ... |
77-243 |
3.43e-66 |
|
DEXH-box helicase domain of DEAH-box helicase 16; DEAH-box helicase 16 (DHX16) is probably involved in pre-mRNA splicing. DHX16 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350732 [Multi-domain] Cd Length: 174 Bit Score: 216.21 E-value: 3.43e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064569 77 LPIFKNRGHILYMCERYRTIIIVGETGCGKSTQVPQFLLEAGWAADGRQIVITQPRRVAVVTLATRVAEEKDCILGHDVG 156
Cdd:cd17974 1 LPVYPYRDDLLAAVKEHQVLIIVGETGSGKTTQIPQYLHEAGYTKGGGKIGCTQPRRVAAMSVAARVAEEMGVKLGNEVG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064569 157 YTVRFDDVSDKDTKVKFMTDGLLLREILADPLLSKYSIIMIDEAHERSCNTDILLGLLRKIIQIRNDLRIIVSSATLDAE 236
Cdd:cd17974 81 YSIRFEDCTSEKTVLKYMTDGMLLREFLTEPDLASYSVMIIDEAHERTLHTDILFGLVKDIARFRPDLKLLISSATMDAE 160
|
....*..
gi 351064569 237 LFKDFFE 243
Cdd:cd17974 161 KFSAFFD 167
|
|
| DEXHc_DHX15 |
cd17973 |
DEXH-box helicase domain of DEAH-box helicase 15; DEAH-box helicase 15 (DHX15) is a pre-mRNA ... |
68-243 |
4.17e-66 |
|
DEXH-box helicase domain of DEAH-box helicase 15; DEAH-box helicase 15 (DHX15) is a pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA. DHX15 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438709 [Multi-domain] Cd Length: 187 Bit Score: 216.51 E-value: 4.17e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064569 68 LNIQQQRIRLPIFKNRGHILYMCERYRTIIIVGETGCGKSTQVPQFLLEAGWA-ADGRQIVITQPRRVAVVTLATRVAEE 146
Cdd:cd17973 4 FEILEKRRELPVWEQKEDFLKLLKNNQILVLVGETGSGKTTQIPQFVLDDELPhQPKKLVACTQPRRVAAMSVAQRVAEE 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064569 147 KDCILGHDVGYTVRFDDVSDKDTKVKFMTDGLLLREILADPLLSKYSIIMIDEAHERSCNTDILLGLLRKIIQIRNDLRI 226
Cdd:cd17973 84 MDVKLGEEVGYSIRFEDCSSAKTILKYMTDGMLLREAMSDPLLSRYSVIILDEAHERTLATDILMGLLKEVVRRRPDLKL 163
|
170
....*....|....*..
gi 351064569 227 IVSSATLDAELFKDFFE 243
Cdd:cd17973 164 IVMSATLDAGKFQKYFD 180
|
|
| DEXHc_DHX38 |
cd17983 |
DEXH-box helicase domain of DEAH-box helicase 38; DEAH-box helicase 38 (DHX38, also known as ... |
77-242 |
7.55e-64 |
|
DEXH-box helicase domain of DEAH-box helicase 38; DEAH-box helicase 38 (DHX38, also known as PRP16) is involved in pre-mRNA splicing. DHX38 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350741 [Multi-domain] Cd Length: 173 Bit Score: 210.01 E-value: 7.55e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064569 77 LPIFKNRGHILYMCERYRTIIIVGETGCGKSTQVPQFLLEAGWAADGrQIVITQPRRVAVVTLATRVAEEKDCILGHDVG 156
Cdd:cd17983 1 LPIFAVRQELLNVIRDNNVVIVVGETGSGKTTQLTQYLHEDGYTDYG-MIGCTQPRRVAAMSVAKRVSEEMGVELGEEVG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064569 157 YTVRFDDVSDKDTKVKFMTDGLLLREILADPLLSKYSIIMIDEAHERSCNTDILLGLLRKIIQIRNDLRIIVSSATLDAE 236
Cdd:cd17983 80 YAIRFEDCTSENTVIKYMTDGILLRESLRDPDLDKYSAIIMDEAHERSLNTDVLFGLLREVVARRRDLKLIVTSATMDAD 159
|
....*.
gi 351064569 237 LFKDFF 242
Cdd:cd17983 160 KFADFF 165
|
|
| DEXHc_DHX37 |
cd17982 |
DEXH-box helicase domain of DEAH-box helicase 37; DHX37 plays a role in the development of the ... |
77-238 |
1.78e-61 |
|
DEXH-box helicase domain of DEAH-box helicase 37; DHX37 plays a role in the development of the human nervous system and has been linked to schizophrenia. It also negatively regulates poxviruses such as Myxoma virus. DEAH-box helicase 37 (DHX37) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350740 [Multi-domain] Cd Length: 191 Bit Score: 204.51 E-value: 1.78e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064569 77 LPIFKNRGHILYMCERYRTIIIVGETGCGKSTQVPQFLLEAGWAADGRQ----IVITQPRRVAVVTLATRVAEEKDcILG 152
Cdd:cd17982 1 LPILAEEQEIMEAINENPVVIICGETGSGKTTQVPQFLYEAGFGSPESDnpgmIGITQPRRVAAVSMAKRVAEELN-VFG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064569 153 HDVGYTVRFDDVSDKDTKVKFMTDGLLLREILADPLLSKYSIIMIDEAHERSCNTDILLGLLRKIIQIRND--------- 223
Cdd:cd17982 80 KEVSYQIRYDSTVSENTKIKFMTDGVLLKEIQTDFLLRKYSVIIIDEAHERSVNTDILIGMLSRIVPLRAKlylqdqtvk 159
|
170
....*....|....*.
gi 351064569 224 -LRIIVSSATLDAELF 238
Cdd:cd17982 160 pLKLVIMSATLRVEDF 175
|
|
| DEXHc_DHX40 |
cd17984 |
DEXH-box helicase domain of DEAH-box helicase 40; DEAH-box helicase 40 (DHX40) belongs to the ... |
77-242 |
6.99e-61 |
|
DEXH-box helicase domain of DEAH-box helicase 40; DEAH-box helicase 40 (DHX40) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350742 [Multi-domain] Cd Length: 178 Bit Score: 202.39 E-value: 6.99e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064569 77 LPIFKNRGHILYMCERYRTIIIVGETGCGKSTQVPQFLLEAGWAADGRqIVITQPRRVAVVTLATRVAEEKDCILGHDVG 156
Cdd:cd17984 1 LPIQKQRKKLVQAVRDNSFLIVTGNTGSGKTTQLPKYLYEAGFSQHGM-IGVTQPRRVAAISVAQRVAEEMKCTLGSKVG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064569 157 YTVRFDDVSDKDTKVKFMTDGLLLREILADPLLSKYSIIMIDEAHERSCNTDILLGLLRKIIQIRN-----DLRIIVSSA 231
Cdd:cd17984 80 YQVRFDDCSSKETAIKYMTDGCLLRHILADPNLTKYSVIILDEAHERSLTTDILFGLLKKLFQEKSpnrkeHLKVVVMSA 159
|
170
....*....|.
gi 351064569 232 TLDAELFKDFF 242
Cdd:cd17984 160 TLELAKLSAFF 170
|
|
| DEXHc_DHX34 |
cd17979 |
DEXH-box helicase domain of DEAH-box helicase 34; DEAH-box helicase 34 (DHX34) plays a role in ... |
77-243 |
1.70e-52 |
|
DEXH-box helicase domain of DEAH-box helicase 34; DEAH-box helicase 34 (DHX34) plays a role in the nonsense-mediated decay (NMD), a surveillance mechanism that degrades aberrant mRNAs. DHX34 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350737 [Multi-domain] Cd Length: 170 Bit Score: 179.18 E-value: 1.70e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064569 77 LPIFKNRGHILYMCERYRTIIIVGETGCGKSTQVPQFLLEAGWaadgRQIVITQPRRVAVVTLATRVAEEKDCILGHDVG 156
Cdd:cd17979 1 LPIAQYREKIIELLKTHQVVIVAGDTGCGKSTQVPQYLLAAGF----RHIACTQPRRIACISLAKRVAFESLNQYGSKVA 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064569 157 YTVRFDDVSDKDTKVKFMTDGLLLREILADPLLSKYSIIMIDEAHERSCNTDILLGLLRKIIQIRNDLRIIVSSATLDAE 236
Cdd:cd17979 77 YQIRFERTRTLATKLLFLTEGLLLRQIQRDASLPQYNVLILDEVHERHLHGDFLLGVLRCLLRLRPDLKLILMSATINIE 156
|
....*..
gi 351064569 237 LFKDFFE 243
Cdd:cd17979 157 LFSGYFE 163
|
|
| DEXHc_HrpA |
cd17989 |
DEXH-box helicase domain of ATP-dependent RNA helicase HrpA; HrpA is part of the HrpB-HrpA ... |
77-260 |
5.12e-52 |
|
DEXH-box helicase domain of ATP-dependent RNA helicase HrpA; HrpA is part of the HrpB-HrpA two-partner secretion (TPS) system, a secretion pathway important to the secretion of large virulence-associated proteins. HrpA belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350747 [Multi-domain] Cd Length: 173 Bit Score: 178.03 E-value: 5.12e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064569 77 LPIFKNRGHILYMCERYRTIIIVGETGCGKSTQVPQFLLEAGWAADGrQIVITQPRRVAVVTLATRVAEEKDCILGHDVG 156
Cdd:cd17989 1 LPVSQKRDEIAKAIAENQVVIIAGETGSGKTTQLPKICLELGRGIRG-LIGHTQPRRLAARSVAERIAEELKTELGGAVG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064569 157 YTVRFDDVSDKDTKVKFMTDGLLLREILADPLLSKYSIIMIDEAHERSCNTDILLGLLRKIIQIRNDLRIIVSSATLDAE 236
Cdd:cd17989 80 YKVRFTDQTSDETCVKLMTDGILLAETQTDRYLRAYDTIIIDEAHERSLNIDFLLGYLKQLLPRRPDLKVIITSATIDAE 159
|
170 180
....*....|....*....|....
gi 351064569 237 LFKDFFemnetgnsdkDTAGIISV 260
Cdd:cd17989 160 RFSRHF----------NNAPIIEV 173
|
|
| DEXHc_DHX29 |
cd17975 |
DEXH-box helicase domain of DEAH-box helicase 29; DEAH-box helicase 29 (DHX29) is a part of ... |
77-242 |
2.32e-47 |
|
DEXH-box helicase domain of DEAH-box helicase 29; DEAH-box helicase 29 (DHX29) is a part of the 43S pre-initiation complex involved in translation initiation of mRNAs with structured 5'-UTRs. DHX29 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350733 [Multi-domain] Cd Length: 183 Bit Score: 165.86 E-value: 2.32e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064569 77 LPIFKNRGHILYMCERYRTIIIVGETGCGKSTQVPQFLLE----AGWAADGRQIVITQPRRVAVVTLATRVAEEKDCILG 152
Cdd:cd17975 1 LPVFKHRESILETLKRHRVVVVAGETGSGKSTQVPQFLLEdlllNGGTAQKCNIVCTQPRRISAMSLATRVCEELGCESG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064569 153 HD-----VGYTVRFDDVSDKDTKVKFMTDGLLLREILADPLLSKYSIIMIDEAHERSCNTDILLGLLRKIIQIRNDLRII 227
Cdd:cd17975 81 PGgknslCGYQIRMESRTGEATRLLYCTTGVLLRKLQEDGLLSSISHIIVDEVHERSVQSDFLLIILKEILHKRSDLHLI 160
|
170
....*....|....*
gi 351064569 228 VSSATLDAELFKDFF 242
Cdd:cd17975 161 LMSATVDCEKFSSYF 175
|
|
| DEXHc_DHX57 |
cd17985 |
DEXH-box helicase domain of DEAH-box helicase 57; DEAH-box helicase 57 (DHX57) belongs to the ... |
77-242 |
4.74e-45 |
|
DEXH-box helicase domain of DEAH-box helicase 57; DEAH-box helicase 57 (DHX57) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350743 [Multi-domain] Cd Length: 177 Bit Score: 159.24 E-value: 4.74e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064569 77 LPIFKNRGHILYMCERYRTIIIVGETGCGKSTQVPQFLLEAgWAADGR----QIVITQPRRVAVVTLATRVAEEKDCILG 152
Cdd:cd17985 1 LPAWQERETILELLEKHQVLVISGMTGCGKTTQIPQFILDN-SLQGPPlpvaNIICTQPRRISAISVAERVAQERAERVG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064569 153 HDVGYTVRFDDVSDKDTKVKFMTDGLLLREILADPLLSKYSIIMIDEAHERSCNTDILLGLLRKIIQIRNDLRIIVSSAT 232
Cdd:cd17985 80 QSVGYQIRLESVKSSATRLLYCTTGVLLRRLEGDPTLQGVTHVIVDEVHERTEESDFLLLVLKDLMVQRPDLKVILMSAT 159
|
170
....*....|
gi 351064569 233 LDAELFKDFF 242
Cdd:cd17985 160 LNAELFSDYF 169
|
|
| DEXHc_DHX36 |
cd17981 |
DEXH-box helicase domain of DEAH-box helicase 36; DEAH-box helicase 36 (DHX36, also known as ... |
77-242 |
3.71e-44 |
|
DEXH-box helicase domain of DEAH-box helicase 36; DEAH-box helicase 36 (DHX36, also known as G4-resolvase 1 or G4R1, MLE-like protein 1 and RNA helicase associated with AU-rich element or RHAU) unwinds a G4-quadruplex in human telomerase RNA. DHX36 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350739 [Multi-domain] Cd Length: 180 Bit Score: 156.93 E-value: 3.71e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064569 77 LPIFKNRGHILYMCERYRTIIIVGETGCGKSTQVPQFLL----EAGWAADGRqIVITQPRRVAVVTLATRVAEEK--DCI 150
Cdd:cd17981 1 LPSYGMKQEIINMIDNNQVTVISGETGCGKTTQVTQFILddaiERGKGSSCR-IVCTQPRRISAISVAERVAAERaeSCG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064569 151 LGHDVGYTVRFDD-VSDKDTKVKFMTDGLLLREILADPLLSKYSIIMIDEAHERSCNTDILLGLLRKIIQIRNDLRIIVS 229
Cdd:cd17981 80 LGNSTGYQIRLESrKPRKQGSILYCTTGIVLQWLQSDPHLSNVSHLVLDEIHERNLQSDVLMGIVKDLLPFRSDLKVILM 159
|
170
....*....|...
gi 351064569 230 SATLDAELFKDFF 242
Cdd:cd17981 160 SATLNAEKFSDYF 172
|
|
| DEXHc_HrpB |
cd17990 |
DEXH-box helicase domain of ATP-dependent helicase HrpB; HrpB is part of the HrpB-HrpA ... |
77-238 |
1.12e-42 |
|
DEXH-box helicase domain of ATP-dependent helicase HrpB; HrpB is part of the HrpB-HrpA two-partner secretion (TPS) system, a secretion pathway important to the secretion of large virulence-associated proteins. HrpB belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438711 [Multi-domain] Cd Length: 174 Bit Score: 152.49 E-value: 1.12e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064569 77 LPIFKNRGHILYMCERYRTIIIVGETGCGKSTQVPQFLLEAGWAADGRqIVITQPRRVAVVTLATRVAEEKDCILGHDVG 156
Cdd:cd17990 1 LPIAAVLPALRAALDAGGQVVLEAPPGAGKTTRVPLALLAELWIAGGK-IIVLEPRRVAARAAARRLATLLGEAPGETVG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064569 157 YTVRFDDVSDKDTKVKFMTDGLLLREILADPLLSKYSIIMIDEAHERSCNTDILLGLLRKIIQ-IRNDLRIIVSSATLDA 235
Cdd:cd17990 80 YRVRGESRVGRRTRVEVVTEGVLLRRLQRDPELSGVGAVILDEFHERSLDADLALALLLEVQQlLRDDLRLLAMSATLDG 159
|
...
gi 351064569 236 ELF 238
Cdd:cd17990 160 DGL 162
|
|
| DEXHc_DHX9 |
cd17972 |
DEXH-box helicase domain of DEAH-box helicase 9; DEAH-box helicase 9 (DHX9, also known as ... |
70-242 |
4.70e-41 |
|
DEXH-box helicase domain of DEAH-box helicase 9; DEAH-box helicase 9 (DHX9, also known as ATP-dependent RNA helicase A or RHA and leukophysin or LKP) plays an important role in many cellular processes, including regulation of DNA replication, transcription, translation, microRNA biogenesis, RNA processing and transport, and maintenance of genomic stability. DHX9 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350730 [Multi-domain] Cd Length: 234 Bit Score: 149.98 E-value: 4.70e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064569 70 IQQQRIRLPIFKNRGHILYMCERYRTIIIVGETGCGKSTQVPQFLLE----AGWAADGrQIVITQPRRVAVVTLATRVAE 145
Cdd:cd17972 52 ILQERELLPVKKFREEILEAISNNPVVIIRGATGCGKTTQVPQYILDdfiqNDRAAEC-NIVVTQPRRISAVSVAERVAF 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064569 146 EKDCILGHDVGYTVRFDDVSDKD-TKVKFMTDGLLLREILADplLSKYSIIMIDEAHERSCNTDILLGLLRKIIQIRNDL 224
Cdd:cd17972 131 ERGEEVGKSCGYSVRFESVLPRPhASILFCTVGVLLRKLEAG--IRGISHVIVDEIHERDINTDFLLVVLRDVVQAYPDL 208
|
170
....*....|....*...
gi 351064569 225 RIIVSSATLDAELFKDFF 242
Cdd:cd17972 209 RVILMSATIDTSMFCEYF 226
|
|
| DEXHc_YTHDC2 |
cd17987 |
DEXH-box helicase domain of YTH domain containing 2; YTH domain containing 2 (YTHDC2) ... |
77-242 |
8.14e-39 |
|
DEXH-box helicase domain of YTH domain containing 2; YTH domain containing 2 (YTHDC2) regulates mRNA translation and stability via binding to N6-methyladenosine, a modified RNA nucleotide enriched in the stop codons and 3' UTRs of eukaryotic messenger RNAs. YTHDC2 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350745 [Multi-domain] Cd Length: 176 Bit Score: 141.89 E-value: 8.14e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064569 77 LPIFKNRGHILYMCERYRTIIIVGETGCGKSTQVPQFLLEAGwAADGR--QIVITQPRRVAVVTLATRVAEEKDCILGHD 154
Cdd:cd17987 1 LPVFEKQEQIVRIIKENKVVLIVGETGSGKTTQIPQFLLDDC-YANGIpcRIFCTQPRRLAAIAVAERVAAERGEKIGQT 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064569 155 VGYTVRFDDVSDKDTKVKFMTDGLLLREILA-DPLLSKYSIIMIDEAHERSCNTDILLGLLRKIIQIRNDLRIIVSSATL 233
Cdd:cd17987 80 VGYQIRLESRVSPKTLLTFCTNGVLLRTLMAgDSALSTVTHVIVDEVHERDRFSDFLLTKLRDILQKHPNLKLILSSAAL 159
|
....*....
gi 351064569 234 DAELFKDFF 242
Cdd:cd17987 160 DVNLFIRYF 168
|
|
| DEXHc_TDRD9 |
cd17988 |
DEXH-box helicase domain of tudor domain containing 9; Tudor domain containing 9 (TDRD9, also ... |
77-244 |
1.23e-38 |
|
DEXH-box helicase domain of tudor domain containing 9; Tudor domain containing 9 (TDRD9, also known as HIG-1or NET54 or C14orf75) is a part of the nuclear PIWI-interacting RNA (piRNA) pathway essential for transposon silencing and male fertility TDRD9 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350746 [Multi-domain] Cd Length: 180 Bit Score: 141.49 E-value: 1.23e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064569 77 LPIFKNRGHILYMCERYRTIIIVGETGCGKSTQVPQFLLEAGWAADGR-QIVITQPRRVAVVTLATRVAEEKDCILGHDV 155
Cdd:cd17988 1 LPIYAKREEILSLIEANSVVIIKGATGCGKTTQLPQFILDHYYKRGKYcNIVVTQPRRIAAISIARRVSQEREWTLGSLV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064569 156 GYTVRFDDVSDKDTKVKFMTDGLLLREILADPLLSKYSIIMIDEAHERSCNTDILLGLLRKIIQIRND-LRIIVSSATLD 234
Cdd:cd17988 81 GYQVGLERPASEETRLIYCTTGVLLQKLINNKTLTEYTHIILDEVHERDQELDFLLLVVRRLLRTNSRhVKIILMSATIS 160
|
170
....*....|
gi 351064569 235 AELFKDFFEM 244
Cdd:cd17988 161 CKEFADYFTT 170
|
|
| DEXHc_DHX30 |
cd17976 |
DEXH-box helicase domain of DEAH-box helicase 30; DEAH-box helicase 30 (DHX30) plays an ... |
77-242 |
2.22e-38 |
|
DEXH-box helicase domain of DEAH-box helicase 30; DEAH-box helicase 30 (DHX30) plays an important role in the assembly of the mitochondrial large ribosomal subunit. DHX30 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350734 [Multi-domain] Cd Length: 178 Bit Score: 140.70 E-value: 2.22e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064569 77 LPIFKNRGHILYMCERYRTIIIVGETGCGKSTQVPQFLLEAGwAADGR----QIVITQPRRVAVVTLATRVAEEKDCILG 152
Cdd:cd17976 1 LPVDSHKESILSAIEQNPVVVISGDTGCGKTTRIPQFILEDY-VLRGRgarcNVVITQPRRISAVSVAQRVAHELGPNLR 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064569 153 HDVGYTVRFDD-VSDKDTKVKFMTDGLLLREILADPLLSKYSIIMIDEAHERSCNTDILLGLLRKIIQIRNDLRIIVSSA 231
Cdd:cd17976 80 RNVGYQVRLESrPPPRGGALLFCTVGVLLKKLQSNPRLEGVSHVIVDEVHERDVNTDFLLILLKGVLQLNPELRVVLMSA 159
|
170
....*....|.
gi 351064569 232 TLDAELFKDFF 242
Cdd:cd17976 160 TGDNQRLSRYF 170
|
|
| DEXQc_DQX1 |
cd17986 |
DEXQ-box helicase domain of DEAQ-box RNA dependent ATPase 1; DEAQ-box RNA dependent ATPase 1 ... |
77-237 |
1.77e-35 |
|
DEXQ-box helicase domain of DEAQ-box RNA dependent ATPase 1; DEAQ-box RNA dependent ATPase 1 (DQX1) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350744 [Multi-domain] Cd Length: 177 Bit Score: 132.33 E-value: 1.77e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064569 77 LPIFKNRGHILYMCERYRTIIIV-GETGCGKSTQVPQ----FLLEAGWAADgrQIVITQPRRVAVVTLATRVAEEKDCIL 151
Cdd:cd17986 1 LPIWAAKFTFLEQLESPSGIVLVsGEPGSGKSTQVPQwcaeFALSRGFQKG--QVTVTQPHPLAARSLALRVADEMDLNL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064569 152 GHDVGYTVRFDDVSDKDTKVKFMTDGLLLREILADPLLSKYSIIMIDEAHERSCNTDILLGLLRKIIQIRNDLR-IIVSS 230
Cdd:cd17986 79 GHEVGYSIPQEDCTGPNTILRFCWDRLLLQEMTSTPLLGAWGVVVLDEAQERSVASDSLLGLLKDVRLQRPELRvVVVTS 158
|
....*..
gi 351064569 231 ATLDAEL 237
Cdd:cd17986 159 PALEPKL 165
|
|
| DEXHc_DHX32 |
cd17977 |
DEXH-box helicase domain of DEAH-box helicase 32; DEAH-box helicase 32 (DHX32) belongs to the ... |
77-231 |
8.21e-35 |
|
DEXH-box helicase domain of DEAH-box helicase 32; DEAH-box helicase 32 (DHX32) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350735 [Multi-domain] Cd Length: 176 Bit Score: 130.33 E-value: 8.21e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064569 77 LPIFKNRGHILYMCERYRTIIIVGETGCGKSTQVPQFLLEAGWAADGRQ--IVITQPRRVAVVTLATRVAEEKDCILGHD 154
Cdd:cd17977 1 LPVWEAKYEFMESLAHNQIVIVSGDAKTGKSSQIPQWCAEYCLSAHYQHgvVVCTQVHKQTAVWLALRVADEMDVNIGHE 80
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 351064569 155 VGYTVRFDDVSDKDTKVKFMTDGLLLREILADPLLSKYSIIMIDEAHERSCNTDILLGLLRKIIQIRNDLRIIVSSA 231
Cdd:cd17977 81 VGYVIPFENCCTNETILRYCTDDMLLREMMSDPLLESYGVIILDDAHERTVSTDVLLGLLKDVLLSRPELKLVIITC 157
|
|
| HA2 |
smart00847 |
Helicase associated domain (HA2) Add an annotation; This presumed domain is about 90 amino ... |
484-568 |
1.23e-27 |
|
Helicase associated domain (HA2) Add an annotation; This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.
Pssm-ID: 214852 [Multi-domain] Cd Length: 82 Bit Score: 106.58 E-value: 1.23e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064569 484 ALGAIDETSQLTsPLGLQMAEFPLPPMHSKCLLKSAEFGCSTEMVTIVAMMQIQDVFitPYRQRHQADVIRKKFAVEEGD 563
Cdd:smart00847 1 ELGALDDDGRLT-PLGRKMAELPLDPRLAKMLLAAAEFGCLDEILTIVAMLSVGDPR--PKEKREDADAARRRFADPESD 77
|
....*
gi 351064569 564 HMTML 568
Cdd:smart00847 78 HLTLL 82
|
|
| HA2 |
pfam04408 |
Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in ... |
479-567 |
1.68e-27 |
|
Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.
Pssm-ID: 461295 [Multi-domain] Cd Length: 104 Bit Score: 106.94 E-value: 1.68e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064569 479 LELLYALGAIDETSQLTsPLGLQMAEFPLPPMHSKCLLKSAEFGCSTEMVTIVAMMQIQDVFITPY-------------R 545
Cdd:pfam04408 2 LELLYYLGALDEDGELT-PLGRKMAELPLDPRLAKMLLAAAELGCLDEVLTIVAALSVRDPFVQPNfldprsaakaarrR 80
|
90 100
....*....|....*....|....
gi 351064569 546 QRHQADVIRKKFAVE--EGDHMTM 567
Cdd:pfam04408 81 RRAADEKARAKFARLdlEGDHLTL 104
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
86-243 |
1.08e-23 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 99.49 E-value: 1.08e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064569 86 ILYMCERYRTIIIVGETGCGKSTQVPQFLLEAGWAADGRQIVITQPRRVAVVTLATRVAEEKDCILGHDVGYTV------ 159
Cdd:smart00487 17 IEALLSGLRDVILAAPTGSGKTLAALLPALEALKRGKGGRVLVLVPTRELAEQWAEELKKLGPSLGLKVVGLYGgdskre 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064569 160 RFDDVSDKDTKVKFMTDGLLLREILADPL-LSKYSIIMIDEAHERS--CNTDILLGLLRKiiqIRNDLRIIVSSATLDAE 236
Cdd:smart00487 97 QLRKLESGKTDILVTTPGRLLDLLENDKLsLSNVDLVILDEAHRLLdgGFGDQLEKLLKL---LPKNVQLLLLSATPPEE 173
|
....*..
gi 351064569 237 LFKDFFE 243
Cdd:smart00487 174 IENLLEL 180
|
|
| PHA02653 |
PHA02653 |
RNA helicase NPH-II; Provisional |
64-425 |
8.05e-18 |
|
RNA helicase NPH-II; Provisional
Pssm-ID: 177443 [Multi-domain] Cd Length: 675 Bit Score: 87.73 E-value: 8.05e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064569 64 PYASLNIQQQRIRLPIFKNRghilymceryRTIIIVGETGCGKSTQVPQFLLEAGWAADG-------------RQIVITQ 130
Cdd:PHA02653 160 PLASLQPDVQLKIFEAWISR----------KPVVLTGGTGVGKTSQVPKLLLWFNYLFGGfdnldkidpnfieRPIVLSL 229
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064569 131 PRrVAVVTLATRVAEEK---DCILGHDVgyTVRFDDVSDKDTKVKFMTDGLLL---REILADplLSKYSIIMIDEAHERS 204
Cdd:PHA02653 230 PR-VALVRLHSITLLKSlgfDEIDGSPI--SLKYGSIPDELINTNPKPYGLVFsthKLTLNK--LFDYGTVIIDEVHEHD 304
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064569 205 CNTDILLGLLRK-IIQIRNdlrIIVSSATL--DAELFKDFFemnetgnsdkDTAGIISVEGRT-HPV--AVHHTKTSVPD 278
Cdd:PHA02653 305 QIGDIIIAVARKhIDKIRS---LFLMTATLedDRDRIKEFF----------PNPAFVHIPGGTlFPIseVYVKNKYNPKN 371
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064569 279 YCQSA------VDTVINIHKHENPGDILVFLTGQDEVEDVCEKLRELAGNLKncdrLWVVpcYGALP-AREQMKAFDSTP 351
Cdd:PHA02653 372 KRAYIeeekknIVTALKKYTPPKGSSGIVFVASVSQCEEYKKYLEKRLPIYD----FYII--HGKVPnIDEILEKVYSSK 445
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 351064569 352 HGTrkVVVATNIAEASITIPGICYVIDTGYVKLRAQHAanGVETLmrvtVSKASAEQRAGRAGRIRPGKCYRLY 425
Cdd:PHA02653 446 NPS--IIISTPYLESSVTIRNATHVYDTGRVYVPEPFG--GKEMF----ISKSMRTQRKGRVGRVSPGTYVYFY 511
|
|
| Helicase_C |
pfam00271 |
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ... |
284-416 |
4.59e-15 |
|
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.
Pssm-ID: 459740 [Multi-domain] Cd Length: 109 Bit Score: 71.47 E-value: 4.59e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064569 284 VDTVINIHKHENPGDILVFLTGQDEVEdvCEKLRELAGnlKNCDRLwvvpcYGALPAREQMKAFDSTPHGTRKVVVATNI 363
Cdd:pfam00271 3 LEALLELLKKERGGKVLIFSQTKKTLE--AELLLEKEG--IKVARL-----HGDLSQEEREEILEDFRKGKIDVLVATDV 73
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 351064569 364 AEASITIPGICYVIDTGYVKlraqhaangvetlmrvtvSKASAEQRAGRAGRI 416
Cdd:pfam00271 74 AERGLDLPDVDLVINYDLPW------------------NPASYIQRIGRAGRA 108
|
|
| OB_NTP_bind |
pfam07717 |
Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus ... |
628-704 |
3.28e-14 |
|
Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus of the DEAD-box helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. There do seem to be a couple of instances where it occurs by itself -. The structure PDB:3i4u adopts an OB-fold. helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. This C-terminal domain of the yeast helicase contains an oligonucleotide/oligosaccharide-binding (OB)-fold which seems to be placed at the entrance of the putative nucleic acid cavity. It also constitutes the binding site for the G-patch-containing domain of Pfa1p. When found on DEAH/RHA helicases, this domain is central to the regulation of the helicase activity through its binding of both RNA and G-patch domain proteins.
Pssm-ID: 400182 [Multi-domain] Cd Length: 82 Bit Score: 68.43 E-value: 3.28e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064569 628 IRQCLVTGFFSQAAQYHYTGK-YMTVKESFPFNMYKgSSIMFKKD--YPKWVIFTEVMQDS---IRDVTVIEPEWLYELA 701
Cdd:pfam07717 1 LRAALAAGLYPNVARRDPKGKgYTTLSDNQRVFIHP-SSVLFNEKtfPPEWVVYQELVETTkvyIRTVTAISPEWLLLFA 79
|
...
gi 351064569 702 PHY 704
Cdd:pfam07717 80 PHI 82
|
|
| HELICc |
smart00490 |
helicase superfamily c-terminal domain; |
317-416 |
2.30e-12 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 63.00 E-value: 2.30e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064569 317 RELAGNLKNCDrLWVVPCYGALPAREQMKAFDSTPHGTRKVVVATNIAEASITIPGICYVIDtgyvklraqhaangvetl 396
Cdd:smart00490 1 EELAELLKELG-IKVARLHGGLSQEEREEILDKFNNGKIKVLVATDVAERGLDLPGVDLVII------------------ 61
|
90 100
....*....|....*....|
gi 351064569 397 MRVTVSKASAEQRAGRAGRI 416
Cdd:smart00490 62 YDLPWSPASYIQRIGRAGRA 81
|
|
| SF2-N |
cd00046 |
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ... |
97-232 |
2.29e-10 |
|
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.
Pssm-ID: 350668 [Multi-domain] Cd Length: 146 Bit Score: 59.34 E-value: 2.29e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064569 97 IIVGETGCGKSTQVPQFLLEAGwAADGRQIVITQPRRvavvTLATRVAEEKDCILGHD--VGYTVRFDDVSDK------D 168
Cdd:cd00046 5 LITAPTGSGKTLAALLAALLLL-LKKGKKVLVLVPTK----ALALQTAERLRELFGPGirVAVLVGGSSAEEReknklgD 79
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 351064569 169 TKVKFMTDGLLLREILADPLL--SKYSIIMIDEAHERSCNTD-ILLGLLRKIIQIRNDLRIIVSSAT 232
Cdd:cd00046 80 ADIIIATPDMLLNLLLREDRLflKDLKLIIVDEAHALLIDSRgALILDLAVRKAGLKNAQVILLSAT 146
|
|
| DEAD |
pfam00270 |
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ... |
96-237 |
1.17e-05 |
|
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.
Pssm-ID: 425570 [Multi-domain] Cd Length: 165 Bit Score: 46.08 E-value: 1.17e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064569 96 IIIVGETGCGKST--QVPqfLLEAGWAAD-GRQIVITQPRRVavvtLATRVAEE-KDCILGHDVGYTVRFDDVSDKD--- 168
Cdd:pfam00270 17 VLVQAPTGSGKTLafLLP--ALEALDKLDnGPQALVLAPTRE----LAEQIYEElKKLGKGLGLKVASLLGGDSRKEqle 90
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 351064569 169 ----TKVKFMTDGLLLREILADPLLSKYSIIMIDEAHErscntdiLLGL-----LRKII-QIRNDLRIIVSSATLDAEL 237
Cdd:pfam00270 91 klkgPDILVGTPGRLLDLLQERKLLKNLKLLVLDEAHR-------LLDMgfgpdLEEILrRLPKKRQILLLSATLPRNL 162
|
|
| DEXHc_Ski2 |
cd17921 |
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases ... |
102-251 |
5.61e-05 |
|
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases play an important role in RNA degradation, processing, and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350679 [Multi-domain] Cd Length: 181 Bit Score: 44.56 E-value: 5.61e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064569 102 TGCGKSTqVPQFLLEAGWAADGRQIVITQPRRvAVVtlATRVAEEKDC--ILGHDVG-----YTVRFDDVSDKD----TK 170
Cdd:cd17921 26 TSSGKTL-IAELAILRALATSGGKAVYIAPTR-ALV--NQKEADLRERfgPLGKNVGlltgdPSVNKLLLAEADilvaTP 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064569 171 VKFmtDGLLLReiLADPLLSKYSIIMIDEAH-----ERScntDILLGLLRKIIQIRNDLRIIVSSATLD-AELFKDFFEM 244
Cdd:cd17921 102 EKL--DLLLRN--GGERLIQDVRLVVVDEAHligdgERG---VVLELLLSRLLRINKNARFVGLSATLPnAEDLAEWLGV 174
|
....*..
gi 351064569 245 NETGNSD 251
Cdd:cd17921 175 EDLIRFD 181
|
|
| SF2_C_LHR |
cd18796 |
C-terminal helicase domain of LHR family helicases; Large helicase-related protein (LHR) is a ... |
253-419 |
1.11e-04 |
|
C-terminal helicase domain of LHR family helicases; Large helicase-related protein (LHR) is a DNA damage-inducible helicase that uses ATP hydrolysis to drive unidirectional 3'-to-5' translocation along single-stranded DNA (ssDNA) and to unwind RNA:DNA duplexes. This group also includes related bacterial and archaeal helicases. LHR family helicases are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350183 [Multi-domain] Cd Length: 150 Bit Score: 43.02 E-value: 1.11e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064569 253 DTAGIISVEGRTHPVAVHHTKTsvpdycqsAVDTVI-NIHKHENpgdILVFLTGQDEVEDVCEKLRELAGNLKNCDRlwv 331
Cdd:cd18796 5 DIKVILPVAPEIFPWAGESGAD--------AYAEVIfLLERHKS---TLVFTNTRSQAERLAQRLRELCPDRVPPDF--- 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064569 332 VPCYGALPAREQ-------MKAfdstphGTRKVVVATNIAEASItipgicyviDTGYVKLRAQHAAngvetlmrvTVSKA 404
Cdd:cd18796 71 IALHHGSLSRELreeveaaLKR------GDLKVVVATSSLELGI---------DIGDVDLVIQIGS---------PKSVA 126
|
170
....*....|....*
gi 351064569 405 SAEQRAGRAGRiRPG 419
Cdd:cd18796 127 RLLQRLGRSGH-RPG 140
|
|
| SF2_C_XPB |
cd18789 |
C-terminal helicase domain of XPB-like helicases; TFIIH basal transcription factor complex ... |
290-420 |
1.88e-04 |
|
C-terminal helicase domain of XPB-like helicases; TFIIH basal transcription factor complex helicase XPB (xeroderma pigmentosum type B) subunit (also known as DNA excision repair protein ERCC-3 or TFIIH 89 kDa subunit) is the ATP-dependent 3'-5' DNA helicase component of the core-TFIIH basal transcription factor, involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. XPB is a DEAD-like helicase belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350176 [Multi-domain] Cd Length: 153 Bit Score: 42.24 E-value: 1.88e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064569 290 IHKHENPGDILVFLTGQDEVEDVCEKLRELAgnlkncdrlwvvpCYGALPAREQMKAFDSTPHGTRKVVVATNIAEASIT 369
Cdd:cd18789 43 LKRHEQGDKIIVFTDNVEALYRYAKRLLKPF-------------ITGETPQSEREEILQNFREGEYNTLVVSKVGDEGID 109
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 351064569 370 IPgicyvidtgyvklraqhAANgveTLMRVTVSKASAEQRAGRAGRI-RPGK 420
Cdd:cd18789 110 LP-----------------EAN---VAIQISGHGGSRRQEAQRLGRIlRPKK 141
|
|
| SF2_C |
cd18785 |
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases ... |
356-425 |
3.76e-04 |
|
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases include DEAD-box helicases, UvrB, RecG, Ski2, Sucrose Non-Fermenting (SNF) family helicases, and dicer proteins, among others. Similar to SF1 helicases, they do not form toroidal structures like SF3-6 helicases. SF2 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350172 [Multi-domain] Cd Length: 77 Bit Score: 39.61 E-value: 3.76e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 351064569 356 KVVVATNIAEASITIPGICYVIDTGYVKlraqhaangvetlmrvtvSKASAEQRAGRAGRI--RPGKCYRLY 425
Cdd:cd18785 24 EILVATNVLGEGIDVPSLDTVIFFDPPS------------------SAASYIQRVGRAGRGgkDEGEVILFV 77
|
|
| AAA_22 |
pfam13401 |
AAA domain; |
96-229 |
1.42e-03 |
|
AAA domain;
Pssm-ID: 379165 [Multi-domain] Cd Length: 129 Bit Score: 39.25 E-value: 1.42e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064569 96 IIIVGETGCGKSTQVpQFLLEAGWAADGRQIVITQPRRVAVVTLATRVAEEkdciLGHDVGYTVRFDDvsdkdtkvkfmt 175
Cdd:pfam13401 8 LVLTGESGTGKTTLL-RRLLEQLPEVRDSVVFVDLPSGTSPKDLLRALLRA----LGLPLSGRLSKEE------------ 70
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 351064569 176 dgllLREILADPLLSKYS--IIMIDEAHerscntDILLGLLRKIIQIRNDLRIIVS 229
Cdd:pfam13401 71 ----LLAALQQLLLALAVavVLIIDEAQ------HLSLEALEELRDLLNLSSKLLQ 116
|
|
| AAA |
smart00382 |
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ... |
92-230 |
4.39e-03 |
|
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.
Pssm-ID: 214640 [Multi-domain] Cd Length: 148 Bit Score: 38.51 E-value: 4.39e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064569 92 RYRTIIIVGETGCGKSTqvpqFLLEAGWAADGRQivitqpRRVAVVTLATRVAEEKDCILGHDVGYTVRFDDVsdkdtkv 171
Cdd:smart00382 1 PGEVILIVGPPGSGKTT----LARALARELGPPG------GGVIYIDGEDILEEVLDQLLLIIVGGKKASGSG------- 63
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 351064569 172 kfmtdGLLLREILADPLLSKYSIIMIDEAH------ERSCNTDILLGLLRKIIQIRNDLRIIVSS 230
Cdd:smart00382 64 -----ELRLRLALALARKLKPDVLILDEITslldaeQEALLLLLEELRLLLLLKSEKNLTVILTT 123
|
|
| |
