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Conserved domains on  [gi|484399596|emb|CCW46000|]
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Protein qui-1 [Caenorhabditis elegans]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455469)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
633-973 2.34e-53

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 192.82  E-value: 2.34e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 484399596  633 IASEQLIGTFKGHTAAVTCLCSSNDSSLFVSTSFDKTVNVWVFSQSTPTMSLTHHTAKVTCAILTSDDQYLITASADSSA 712
Cdd:COG2319    65 AAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTV 144

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 484399596  713 KMIKLETGEVMRSFNDHTGSVVSLQLTSNNQFLITGSGDFVVQMWDVTNGKCISRMGGLMAPVSTLAITSNDAFVVVACE 792
Cdd:COG2319   145 RLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSA 224

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 484399596  793 DETLKVFSTVGGQELHELMGHEGKVNSLVCAQDDCQLFAATKSK-VFCYDIHNGQMIDVLdTAQPFPICSLKISSDNYFL 871
Cdd:COG2319   225 DGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGtVRLWDLATGELLRTL-TGHSGGVNSVAFSPDGKLL 303

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 484399596  872 ISPCGPK-VTIWNVTK----RNHDAHDvhadkeGFLTAVALSNDDKYAACGTNNGIVALWDLEVCQCVfTTIQNKGDPIT 946
Cdd:COG2319   304 ASGSDDGtVRLWDLATgkllRTLTGHT------GAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELL-RTLTGHTGAVT 376

                         330       340
                  ....*....|....*....|....*..
gi 484399596  947 CIRYSVDSQYCISGNQAGCILILDAQN 973
Cdd:COG2319   377 SVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 892-1182 5.00e-49

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


:

Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 176.37  E-value: 5.00e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 484399596  892 HDVHADKEGFLTAVALSNDDKYAACGTNNGIVALWDLEVCQCvFTTIQNKGDPITCIRYSVDSQYCISGNQAGCILILDA 971
Cdd:cd00200     2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGEL-LRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 484399596  972 QNGGVVRELFMHSSEVLSIMSLVHNKMI-SCDIQGKMVIWELfgDDDTPEMVATGVKPPI---FVPPTGRIMVGhcSLSN 1047
Cdd:cd00200    81 ETGECVRTLTGHTSYVSSVAFSPDGRILsSSSRDKTIKVWDV--ETGKCLTTLRGHTDWVnsvAFSPDGTFVAS--SSQD 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 484399596 1048 KEMKIWAFpEEGPPVTRAKlSHSDEITCFATSPKGGNFIaTGSRDMSLKIWQIDKGFLTQVLVGHENVVTCCCISFDERL 1127
Cdd:cd00200   157 GTIKLWDL-RTGKCVATLT-GHTGEVNSVAFSPDGEKLL-SSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYL 233

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 484399596 1128 VVSGARDEKIIVWNVQSGDMVCTV-NTTAAITSLSMTGDSTVVFSTTEDGWVETWS 1182
Cdd:cd00200   234 LASGSEDGTIRVWDLRTGECVQTLsGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
633-973 2.34e-53

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 192.82  E-value: 2.34e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 484399596  633 IASEQLIGTFKGHTAAVTCLCSSNDSSLFVSTSFDKTVNVWVFSQSTPTMSLTHHTAKVTCAILTSDDQYLITASADSSA 712
Cdd:COG2319    65 AAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTV 144

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 484399596  713 KMIKLETGEVMRSFNDHTGSVVSLQLTSNNQFLITGSGDFVVQMWDVTNGKCISRMGGLMAPVSTLAITSNDAFVVVACE 792
Cdd:COG2319   145 RLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSA 224

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 484399596  793 DETLKVFSTVGGQELHELMGHEGKVNSLVCAQDDCQLFAATKSK-VFCYDIHNGQMIDVLdTAQPFPICSLKISSDNYFL 871
Cdd:COG2319   225 DGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGtVRLWDLATGELLRTL-TGHSGGVNSVAFSPDGKLL 303

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 484399596  872 ISPCGPK-VTIWNVTK----RNHDAHDvhadkeGFLTAVALSNDDKYAACGTNNGIVALWDLEVCQCVfTTIQNKGDPIT 946
Cdd:COG2319   304 ASGSDDGtVRLWDLATgkllRTLTGHT------GAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELL-RTLTGHTGAVT 376

                         330       340
                  ....*....|....*....|....*..
gi 484399596  947 CIRYSVDSQYCISGNQAGCILILDAQN 973
Cdd:COG2319   377 SVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 638-927 5.23e-50

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 179.07  E-value: 5.23e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 484399596  638 LIGTFKGHTAAVTCLCSSNDSSLFVSTSFDKTVNVWVFSQSTPTMSLTHHTAKVTCAILTSDDQYLITASADSSAKMIKL 717
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 484399596  718 ETGEVMRSFNDHTGSVVSLQLTSNNQFLITGSGDFVVQMWDVTNGKCISRMGGLMAPVSTLAITSNDAFVVVACEDETLK 797
Cdd:cd00200    81 ETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 484399596  798 VFSTVGGQELHELMGHEGKVNSLVCAQDDCQLFAAT-KSKVFCYDIHNGQMIDVLdTAQPFPICSLKISSDNYFLIS-PC 875
Cdd:cd00200   161 LWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSsDGTIKLWDLSTGKCLGTL-RGHENGVNSVAFSPDGYLLASgSE 239

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 484399596  876 GPKVTIWNVTKRNHD----AHdvhadkEGFLTAVALSNDDKYAACGTNNGIVALWD 927
Cdd:cd00200   240 DGTIRVWDLRTGECVqtlsGH------TNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 892-1182 5.00e-49

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 176.37  E-value: 5.00e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 484399596  892 HDVHADKEGFLTAVALSNDDKYAACGTNNGIVALWDLEVCQCvFTTIQNKGDPITCIRYSVDSQYCISGNQAGCILILDA 971
Cdd:cd00200     2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGEL-LRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 484399596  972 QNGGVVRELFMHSSEVLSIMSLVHNKMI-SCDIQGKMVIWELfgDDDTPEMVATGVKPPI---FVPPTGRIMVGhcSLSN 1047
Cdd:cd00200    81 ETGECVRTLTGHTSYVSSVAFSPDGRILsSSSRDKTIKVWDV--ETGKCLTTLRGHTDWVnsvAFSPDGTFVAS--SSQD 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 484399596 1048 KEMKIWAFpEEGPPVTRAKlSHSDEITCFATSPKGGNFIaTGSRDMSLKIWQIDKGFLTQVLVGHENVVTCCCISFDERL 1127
Cdd:cd00200   157 GTIKLWDL-RTGKCVATLT-GHTGEVNSVAFSPDGEKLL-SSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYL 233

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 484399596 1128 VVSGARDEKIIVWNVQSGDMVCTV-NTTAAITSLSMTGDSTVVFSTTEDGWVETWS 1182
Cdd:cd00200   234 LASGSEDGTIRVWDLRTGECVQTLsGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
1051-1197 1.43e-21

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 98.83  E-value: 1.43e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 484399596 1051 KIWAFpeEGPPVTRAKLSHSDEITCFATSPkGGNFIATGSRDMSLKIWQIDKGFLTQVLVGHENVVTCCCISFDERLVVS 1130
Cdd:COG2319   103 RLWDL--ATGLLLRTLTGHTGAVRSVAFSP-DGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLAS 179

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 484399596 1131 GARDEKIIVWNVQSGDMVCTVN-TTAAITSLSMTGDSTVVFSTTEDGWVETWSTTKGRLLSTFNAHRP 1197
Cdd:COG2319   180 GSDDGTVRLWDLATGKLLRTLTgHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSG 247
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 635-673 4.71e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 50.39  E-value: 4.71e-08
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 484399596    635 SEQLIGTFKGHTAAVTCLCSSNDSSLFVSTSFDKTVNVW 673
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
637-673 9.20e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 49.27  E-value: 9.20e-08
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 484399596   637 QLIGTFKGHTAAVTCLCSSNDSSLFVSTSFDKTVNVW 673
Cdd:pfam00400    2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 1069-1148 2.01e-06

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 51.61  E-value: 2.01e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 484399596  1069 HSDEITCFATSPKGgNFIATGSRDMSLKIWQIDKGFLTQ-----------------------VLVGHENVVTCCCISFDE 1125
Cdd:pfam20426  123 HKDVVSCVAVTSDG-SILATGSYDTTVMVWEVLRGRSSEkrsrntqtefprkdhviaetpfhILCGHDDIITCLYVSVEL 201

                           90       100
                   ....*....|....*....|...
gi 484399596  1126 RLVVSGARDEKIIVWNVQSGDMV 1148
Cdd:pfam20426  202 DIVISGSKDGTCIFHTLREGRYV 224
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 1102-1141 2.73e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.30  E-value: 2.73e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 484399596   1102 KGFLTQVLVGHENVVTCCCISFDERLVVSGARDEKIIVWN 1141
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 647-866 1.48e-04

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 46.23  E-value: 1.48e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 484399596  647 AAVTCLC-SSNDSSLFVSTSFDKTVNVWVFSQSTPTMSLTHHTAKV-TCAILTSDDQYLITASADSSAKMIKLETGEVMR 724
Cdd:PLN00181  533 SKLSGICwNSYIKSQVASSNFEGVVQVWDVARSQLVTEMKEHEKRVwSIDYSSADPTLLASGSDDGSVKLWSINQGVSIG 612

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 484399596  725 SFNDhTGSVVSLQLTSNN-QFLITGSGDFVVQMWDVTNGKC-ISRMGGLMAPVSTLAITSNDAfVVVACEDETLKVF--- 799
Cdd:PLN00181  613 TIKT-KANICCVQFPSESgRSLAFGSADHKVYYYDLRNPKLpLCTMIGHSKTVSYVRFVDSST-LVSSSTDNTLKLWdls 690

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 484399596  800 ---STVGGQELHELMGHEGKVNSLVCAQDDCQLFAATKS-KVFCYdihngqmidvlDTAQPFPICSLKISS 866
Cdd:PLN00181  691 msiSGINETPLHSFMGHTNVKNFVGLSVSDGYIATGSETnEVFVY-----------HKAFPMPVLSYKFKT 750
PTZ00421 PTZ00421
coronin; Provisional
 1053-1159 2.57e-04

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 45.27  E-value: 2.57e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 484399596 1053 WAFPEEG------PPVTRAKlSHSDEITCFATSPKGGNFIATGSRDMSLKIWQIDKGFLTQVLVGHENVVTCCCISFDER 1126
Cdd:PTZ00421  103 WGIPEEGltqnisDPIVHLQ-GHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVERGKAVEVIKCHSDQITSLEWNLDGS 181

                          90       100       110
                  ....*....|....*....|....*....|...
gi 484399596 1127 LVVSGARDEKIIVWNVQSGDMVCTVNTTAAITS 1159
Cdd:PTZ00421  182 LLCTTSKDKKLNIIDPRDGTIVSSVEAHASAKS 214
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
633-973 2.34e-53

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 192.82  E-value: 2.34e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 484399596  633 IASEQLIGTFKGHTAAVTCLCSSNDSSLFVSTSFDKTVNVWVFSQSTPTMSLTHHTAKVTCAILTSDDQYLITASADSSA 712
Cdd:COG2319    65 AAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTV 144

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 484399596  713 KMIKLETGEVMRSFNDHTGSVVSLQLTSNNQFLITGSGDFVVQMWDVTNGKCISRMGGLMAPVSTLAITSNDAFVVVACE 792
Cdd:COG2319   145 RLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSA 224

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 484399596  793 DETLKVFSTVGGQELHELMGHEGKVNSLVCAQDDCQLFAATKSK-VFCYDIHNGQMIDVLdTAQPFPICSLKISSDNYFL 871
Cdd:COG2319   225 DGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGtVRLWDLATGELLRTL-TGHSGGVNSVAFSPDGKLL 303

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 484399596  872 ISPCGPK-VTIWNVTK----RNHDAHDvhadkeGFLTAVALSNDDKYAACGTNNGIVALWDLEVCQCVfTTIQNKGDPIT 946
Cdd:COG2319   304 ASGSDDGtVRLWDLATgkllRTLTGHT------GAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELL-RTLTGHTGAVT 376

                         330       340
                  ....*....|....*....|....*..
gi 484399596  947 CIRYSVDSQYCISGNQAGCILILDAQN 973
Cdd:COG2319   377 SVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
623-929 1.30e-51

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 187.81  E-value: 1.30e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 484399596  623 SDPGVIYAYHIASEQLIGTFKGHTAAVTCLCSSNDSSLFVSTSFDKTVNVWVFSQSTPTMSLTHHTAKVTCAILTSDDQY 702
Cdd:COG2319    97 SADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKL 176

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 484399596  703 LITASADSSAKMIKLETGEVMRSFNDHTGSVVSLQLTSNNQFLITGSGDFVVQMWDVTNGKCISRMGGLMAPVSTLAITS 782
Cdd:COG2319   177 LASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSP 256

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 484399596  783 NDAFVVVACEDETLKVFSTVGGQELHELMGHEGKVNSLVCAQDDCQLFAATKSK-VFCYDIHNGQMIDVLdTAQPFPICS 861
Cdd:COG2319   257 DGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGtVRLWDLATGKLLRTL-TGHTGAVRS 335

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 484399596  862 LKISSDNYFLISPCGPK-VTIWNV-------TKRNHdahdvhadkEGFLTAVALSNDDKYAACGTNNGIVALWDLE 929
Cdd:COG2319   336 VAFSPDGKTLASGSDDGtVRLWDLatgellrTLTGH---------TGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
634-1144 8.31e-51

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 185.11  E-value: 8.31e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 484399596  634 ASEQLIGTFKGHTAAVTCLCSSNDSSLFVSTSFDKTVNVWVFSQSTPTMSLTHHTAKVTCAILTSDDQYLITASADSSAK 713
Cdd:COG2319    24 ALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVR 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 484399596  714 MIKLETGEVMRSFNDHTGSVVSLQLTSNNQFLITGSGDFVVQMWDVTNGKCISRMGGLMAPVSTLAITSNDAFVVVACED 793
Cdd:COG2319   104 LWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDD 183

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 484399596  794 ETLKVFSTVGGQELHELMGHEGKVNSLVCAQDDCQLFAAtkskvfcydihngqmidvldtaqpfpicslkiSSDNyflis 873
Cdd:COG2319   184 GTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASG--------------------------------SADG----- 226

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 484399596  874 pcgpKVTIWNVTKRnhDAHDVHADKEGFLTAVALSNDDKYAACGTNNGIVALWDLEVCQCVfTTIQNKGDPITCIRYSVD 953
Cdd:COG2319   227 ----TVRLWDLATG--KLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELL-RTLTGHSGGVNSVAFSPD 299

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 484399596  954 SQYCISGNqagcilildaqNGGVVRelfmhssevlsimslvhnkmiscdiqgkmvIWELfgddDTPEMVATgvkppifvp 1033
Cdd:COG2319   300 GKLLASGS-----------DDGTVR------------------------------LWDL----ATGKLLRT--------- 325

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 484399596 1034 PTGrimvghcslsnkemkiwafpeegppvtraklsHSDEITCFATSPKgGNFIATGSRDMSLKIWQIDKGFLTQVLVGHE 1113
Cdd:COG2319   326 LTG--------------------------------HTGAVRSVAFSPD-GKTLASGSDDGTVRLWDLATGELLRTLTGHT 372

                         490       500       510
                  ....*....|....*....|....*....|.
gi 484399596 1114 NVVTCCCISFDERLVVSGARDEKIIVWNVQS 1144
Cdd:COG2319   373 GAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 638-927 5.23e-50

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 179.07  E-value: 5.23e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 484399596  638 LIGTFKGHTAAVTCLCSSNDSSLFVSTSFDKTVNVWVFSQSTPTMSLTHHTAKVTCAILTSDDQYLITASADSSAKMIKL 717
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 484399596  718 ETGEVMRSFNDHTGSVVSLQLTSNNQFLITGSGDFVVQMWDVTNGKCISRMGGLMAPVSTLAITSNDAFVVVACEDETLK 797
Cdd:cd00200    81 ETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 484399596  798 VFSTVGGQELHELMGHEGKVNSLVCAQDDCQLFAAT-KSKVFCYDIHNGQMIDVLdTAQPFPICSLKISSDNYFLIS-PC 875
Cdd:cd00200   161 LWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSsDGTIKLWDLSTGKCLGTL-RGHENGVNSVAFSPDGYLLASgSE 239

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 484399596  876 GPKVTIWNVTKRNHD----AHdvhadkEGFLTAVALSNDDKYAACGTNNGIVALWD 927
Cdd:cd00200   240 DGTIRVWDLRTGECVqtlsGH------TNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 892-1182 5.00e-49

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 176.37  E-value: 5.00e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 484399596  892 HDVHADKEGFLTAVALSNDDKYAACGTNNGIVALWDLEVCQCvFTTIQNKGDPITCIRYSVDSQYCISGNQAGCILILDA 971
Cdd:cd00200     2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGEL-LRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 484399596  972 QNGGVVRELFMHSSEVLSIMSLVHNKMI-SCDIQGKMVIWELfgDDDTPEMVATGVKPPI---FVPPTGRIMVGhcSLSN 1047
Cdd:cd00200    81 ETGECVRTLTGHTSYVSSVAFSPDGRILsSSSRDKTIKVWDV--ETGKCLTTLRGHTDWVnsvAFSPDGTFVAS--SSQD 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 484399596 1048 KEMKIWAFpEEGPPVTRAKlSHSDEITCFATSPKGGNFIaTGSRDMSLKIWQIDKGFLTQVLVGHENVVTCCCISFDERL 1127
Cdd:cd00200   157 GTIKLWDL-RTGKCVATLT-GHTGEVNSVAFSPDGEKLL-SSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYL 233

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 484399596 1128 VVSGARDEKIIVWNVQSGDMVCTV-NTTAAITSLSMTGDSTVVFSTTEDGWVETWS 1182
Cdd:cd00200   234 LASGSEDGTIRVWDLRTGECVQTLsGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
657-1196 9.89e-41

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 155.84  E-value: 9.89e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 484399596  657 DSSLFVSTSFDKTVNVWVFSQSTPTMSLTHHTAKVTCAILTSDDQYLITASADSSAKMIKLETGEVMRSFNDHTGSVVSL 736
Cdd:COG2319     5 DGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSV 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 484399596  737 QLTSNNQFLITGSGDFVVQMWDVTNGKCISRMGGLMAPVSTLAITSNDAFVVVACEDETLKVFSTVGGQELHELMGHEGK 816
Cdd:COG2319    85 AFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGA 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 484399596  817 VNSlvcaqddcqlfaatkskvfcydihngqmidvldtaqpfpicslkissdnyflispcgpkvtiwnvtkrnhdahdvha 896
Cdd:COG2319   165 VTS----------------------------------------------------------------------------- 167

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 484399596  897 dkegfltaVALSNDDKYAACGTNNGIVALWDLEVCQCVfTTIQNKGDPITCIRYSVDSQYCISGNQAGCILILDAQNGGV 976
Cdd:COG2319   168 --------VAFSPDGKLLASGSDDGTVRLWDLATGKLL-RTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKL 238

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 484399596  977 VRELFMHSSEVLSImslvhnkmiscdiqgkmviwelfgdddtpemvatgvkppifvpptgrimvghcslsnkemkiwAFp 1056
Cdd:COG2319   239 LRTLTGHSGSVRSV---------------------------------------------------------------AF- 254

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 484399596 1057 eegppvtraklshsdeitcfatSPkGGNFIATGSRDMSLKIWQIDKGFLTQVLVGHENVVTCCCISFDERLVVSGARDEK 1136
Cdd:COG2319   255 ----------------------SP-DGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGT 311

                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 484399596 1137 IIVWNVQSGDMVCTVN-TTAAITSLSMTGDSTVVFSTTEDGWVETWSTTKGRLLSTFNAHR 1196
Cdd:COG2319   312 VRLWDLATGKLLRTLTgHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHT 372
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 610-832 3.25e-40

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 150.95  E-value: 3.25e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 484399596  610 SANHQYILISgnqSDPGVIYAYHIASEQLIGTFKGHTAAVTCLCSSNDSSLFVSTSFDKTVNVWVFSQSTPTMSLTHHTA 689
Cdd:cd00200    60 SADGTYLASG---SSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTD 136

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 484399596  690 KVTCAILTSDDQYLITASADSSAKMIKLETGEVMRSFNDHTGSVVSLQLTSNNQFLITGSGDFVVQMWDVTNGKCISRMG 769
Cdd:cd00200   137 WVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLR 216

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 484399596  770 GLMAPVSTLAITSNDAFVVVACEDETLKVFSTVGGQELHELMGHEGKVNSLVCAQDDCQLFAA 832
Cdd:cd00200   217 GHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASG 279
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 605-873 7.83e-40

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 149.79  E-value: 7.83e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 484399596  605 TVLTLSANHQYILISGnqSDpGVIYAYHIASEQLIGTFKGHTAAVTCLCSSNDSSLFVSTSFDKTVNVWVFSQSTPTMSL 684
Cdd:cd00200    13 TCVAFSPDGKLLATGS--GD-GTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTL 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 484399596  685 THHTAKVTCAILTSDDQYLITASADSSAKMIKLETGEVMRSFNDHTGSVVSLQLTSNNQFLITGSGDFVVQMWDVTNGKC 764
Cdd:cd00200    90 TGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKC 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 484399596  765 ISRMGGLMAPVSTLAITSNDAFVVVACEDETLKVFSTVGGQELHELMGHEGKVNSLVCAQDDCQLFAATK-SKVFCYDIH 843
Cdd:cd00200   170 VATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEdGTIRVWDLR 249

                         250       260       270
                  ....*....|....*....|....*....|
gi 484399596  844 NGQMIDVLdTAQPFPICSLKISSDNYFLIS 873
Cdd:cd00200   250 TGECVQTL-SGHTNSVTSLAWSPDGKRLAS 278
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 607-800 4.05e-28

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 115.90  E-value: 4.05e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 484399596  607 LTLSANHQYILISGNQsdpGVIYAYHIASEQLIGTFKGHTAAVTCLCSSNDSSLFVSTSFDKTVNVWVFSQSTPTMSLTH 686
Cdd:cd00200    99 VAFSPDGRILSSSSRD---KTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTG 175

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 484399596  687 HTAKVTCAILTSDDQYLITASADSSAKMIKLETGEVMRSFNDHTGSVVSLQLTSNNQFLITGSGDFVVQMWDVTNGKCIS 766
Cdd:cd00200   176 HTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQ 255

                         170       180       190
                  ....*....|....*....|....*....|....
gi 484399596  767 RMGGLMAPVSTLAITSNDAFVVVACEDETLKVFS 800
Cdd:cd00200   256 TLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
616-761 3.65e-25

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 109.62  E-value: 3.65e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 484399596  616 ILISGnqSDPGVIYAYHIASEQLIGTFKGHTAAVTCLCSSNDSSLFVSTSFDKTVNVWVFSQSTPTMSLTHHTAKVTCAI 695
Cdd:COG2319   260 LLASG--SADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVA 337

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 484399596  696 LTSDDQYLITASADSSAKMIKLETGEVMRSFNDHTGSVVSLQLTSNNQFLITGSGDFVVQMWDVTN 761
Cdd:COG2319   338 FSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
1051-1197 1.43e-21

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 98.83  E-value: 1.43e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 484399596 1051 KIWAFpeEGPPVTRAKLSHSDEITCFATSPkGGNFIATGSRDMSLKIWQIDKGFLTQVLVGHENVVTCCCISFDERLVVS 1130
Cdd:COG2319   103 RLWDL--ATGLLLRTLTGHTGAVRSVAFSP-DGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLAS 179

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 484399596 1131 GARDEKIIVWNVQSGDMVCTVN-TTAAITSLSMTGDSTVVFSTTEDGWVETWSTTKGRLLSTFNAHRP 1197
Cdd:COG2319   180 GSDDGTVRLWDLATGKLLRTLTgHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSG 247
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 1068-1196 4.86e-20

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 92.01  E-value: 4.86e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 484399596 1068 SHSDEITCFATSPkGGNFIATGSRDMSLKIWQIDKGFLTQVLVGHENVVTCCCISFDERLVVSGARDEKIIVWNVQSGDM 1147
Cdd:cd00200     7 GHTGGVTCVAFSP-DGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGEC 85

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 484399596 1148 VCTVNT-TAAITSLSMTGDSTVVFSTTEDGWVETWSTTKGRLLSTFNAHR 1196
Cdd:cd00200    86 VRTLTGhTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHT 135
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 1105-1195 1.63e-12

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 69.67  E-value: 1.63e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 484399596 1105 LTQVLVGHENVVTCCCISFDERLVVSGARDEKIIVWNVQSGDMVCT-VNTTAAITSLSMTGDSTVVFSTTEDGWVETWST 1183
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTlKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                          90
                  ....*....|..
gi 484399596 1184 TKGRLLSTFNAH 1195
Cdd:cd00200    81 ETGECVRTLTGH 92
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 635-673 4.71e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 50.39  E-value: 4.71e-08
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 484399596    635 SEQLIGTFKGHTAAVTCLCSSNDSSLFVSTSFDKTVNVW 673
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
637-673 9.20e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 49.27  E-value: 9.20e-08
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 484399596   637 QLIGTFKGHTAAVTCLCSSNDSSLFVSTSFDKTVNVW 673
Cdd:pfam00400    2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 1069-1148 2.01e-06

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 51.61  E-value: 2.01e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 484399596  1069 HSDEITCFATSPKGgNFIATGSRDMSLKIWQIDKGFLTQ-----------------------VLVGHENVVTCCCISFDE 1125
Cdd:pfam20426  123 HKDVVSCVAVTSDG-SILATGSYDTTVMVWEVLRGRSSEkrsrntqtefprkdhviaetpfhILCGHDDIITCLYVSVEL 201

                           90       100
                   ....*....|....*....|...
gi 484399596  1126 RLVVSGARDEKIIVWNVQSGDMV 1148
Cdd:pfam20426  202 DIVISGSKDGTCIFHTLREGRYV 224
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 719-758 1.47e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.07  E-value: 1.47e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 484399596    719 TGEVMRSFNDHTGSVVSLQLTSNNQFLITGSGDFVVQMWD 758
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
1103-1141 1.52e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.10  E-value: 1.52e-05
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 484399596  1103 GFLTQVLVGHENVVTCCCISFDERLVVSGARDEKIIVWN 1141
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 1102-1141 2.73e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.30  E-value: 2.73e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 484399596   1102 KGFLTQVLVGHENVVTCCCISFDERLVVSGARDEKIIVWN 1141
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
720-758 1.28e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.41  E-value: 1.28e-04
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 484399596   720 GEVMRSFNDHTGSVVSLQLTSNNQFLITGSGDFVVQMWD 758
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 647-866 1.48e-04

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 46.23  E-value: 1.48e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 484399596  647 AAVTCLC-SSNDSSLFVSTSFDKTVNVWVFSQSTPTMSLTHHTAKV-TCAILTSDDQYLITASADSSAKMIKLETGEVMR 724
Cdd:PLN00181  533 SKLSGICwNSYIKSQVASSNFEGVVQVWDVARSQLVTEMKEHEKRVwSIDYSSADPTLLASGSDDGSVKLWSINQGVSIG 612

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 484399596  725 SFNDhTGSVVSLQLTSNN-QFLITGSGDFVVQMWDVTNGKC-ISRMGGLMAPVSTLAITSNDAfVVVACEDETLKVF--- 799
Cdd:PLN00181  613 TIKT-KANICCVQFPSESgRSLAFGSADHKVYYYDLRNPKLpLCTMIGHSKTVSYVRFVDSST-LVSSSTDNTLKLWdls 690

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 484399596  800 ---STVGGQELHELMGHEGKVNSLVCAQDDCQLFAATKS-KVFCYdihngqmidvlDTAQPFPICSLKISS 866
Cdd:PLN00181  691 msiSGINETPLHSFMGHTNVKNFVGLSVSDGYIATGSETnEVFVY-----------HKAFPMPVLSYKFKT 750
PTZ00421 PTZ00421
coronin; Provisional
 1053-1159 2.57e-04

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 45.27  E-value: 2.57e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 484399596 1053 WAFPEEG------PPVTRAKlSHSDEITCFATSPKGGNFIATGSRDMSLKIWQIDKGFLTQVLVGHENVVTCCCISFDER 1126
Cdd:PTZ00421  103 WGIPEEGltqnisDPIVHLQ-GHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVERGKAVEVIKCHSDQITSLEWNLDGS 181

                          90       100       110
                  ....*....|....*....|....*....|...
gi 484399596 1127 LVVSGARDEKIIVWNVQSGDMVCTVNTTAAITS 1159
Cdd:PTZ00421  182 LLCTTSKDKKLNIIDPRDGTIVSSVEAHASAKS 214
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 1075-1142 3.47e-04

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 44.29  E-value: 3.47e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 484399596  1075 CFAT--SPKGGNFIATGSRDMSLKIWQIDKGFLTQVLVGHENVVTCCCISFDERLVVSGARDEKIIVWNV 1142
Cdd:pfam20426   84 CFATlqTPSENFLISCGNWENSFQVISLNDGRMVQSIRQHKDVVSCVAVTSDGSILATGSYDTTVMVWEV 153
WD40 pfam00400
WD domain, G-beta repeat;
1069-1098 6.76e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.48  E-value: 6.76e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 484399596  1069 HSDEITCFATSPKGgNFIATGSRDMSLKIW 1098
Cdd:pfam00400   10 HTGSVTSLAFSPDG-KLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 1069-1098 8.88e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.06  E-value: 8.88e-04
                            10        20        30
                    ....*....|....*....|....*....|
gi 484399596   1069 HSDEITCFATSPKGgNFIATGSRDMSLKIW 1098
Cdd:smart00320   11 HTGPVTSVAFSPDG-KYLASGSDDGTIKLW 39
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 694-763 3.97e-03

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 41.21  E-value: 3.97e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 484399596   694 AILTSDDQYLIT-ASADSSAKMIKLETGEVMRSFNDHTGSVVSLQLTSNNQFLITGSGDFVVQMWDVTNGK 763
Cdd:pfam20426   87 TLQTPSENFLIScGNWENSFQVISLNDGRMVQSIRQHKDVVSCVAVTSDGSILATGSYDTTVMVWEVLRGR 157
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 677-714 5.33e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.14  E-value: 5.33e-03
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 484399596    677 QSTPTMSLTHHTAKVTCAILTSDDQYLITASADSSAKM 714
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKL 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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