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Conserved domains on  [gi|524144797|emb|CCZ16114|]
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endonuclease III [Sutterella wadsworthensis CAG:135]

Protein Classification

endonuclease III domain-containing protein( domain architecture ID 11415064)

endonuclease III domain-containing protein such as endonuclease III, a DNA repair enzyme that has both DNA N-glycosylase and AP-lyase activities

CATH:  1.10.1670.10
Gene Ontology:  GO:0016798|GO:0006284|GO:0051539
PubMed:  10908318|1411536
SCOP:  4001141

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Nth COG0177
Endonuclease III [Replication, recombination and repair];
11-204 2.43e-118

Endonuclease III [Replication, recombination and repair];


:

Pssm-ID: 439947 [Multi-domain]  Cd Length: 198  Bit Score: 335.91  E-value: 2.43e-118
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 524144797  11 MAALAALNPNPKSELNYSTPFELLVAVMLSAQATDKGVNLATAKLFPVANTPQKILDLGLDGLIPYVQTINLYRTKAQHL 90
Cdd:COG0177    1 LERLKELYPDAKTELDYRDPFELLVATILSAQTTDERVNKATPRLFARYPTPEALAAADLEELEELIRPIGLYRNKAKNI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 524144797  91 IEACRILIDRFHGEVPRTRDELVSLPGVGRKTANVVMNVAFGEPAIAVDTHIFRVCNRTGFAPGKTPAEVEEKLLKVVPK 170
Cdd:COG0177   81 IALARILVEKYGGEVPETREELESLPGVGRKTANVVLNFAFGKPAIAVDTHVHRVSNRLGLVPGKDPEEVEKDLMKLIPK 160

                        170       180       190
                 ....*....|....*....|....*....|....
gi 524144797 171 DYLLNAHHWLLLFGRYICKARNPECIRCPVAEYC 204
Cdd:COG0177  161 EYWGDLHHLLILHGRYICKARKPKCEECPLADLC 194
 
Name Accession Description Interval E-value
Nth COG0177
Endonuclease III [Replication, recombination and repair];
11-204 2.43e-118

Endonuclease III [Replication, recombination and repair];


Pssm-ID: 439947 [Multi-domain]  Cd Length: 198  Bit Score: 335.91  E-value: 2.43e-118
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 524144797  11 MAALAALNPNPKSELNYSTPFELLVAVMLSAQATDKGVNLATAKLFPVANTPQKILDLGLDGLIPYVQTINLYRTKAQHL 90
Cdd:COG0177    1 LERLKELYPDAKTELDYRDPFELLVATILSAQTTDERVNKATPRLFARYPTPEALAAADLEELEELIRPIGLYRNKAKNI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 524144797  91 IEACRILIDRFHGEVPRTRDELVSLPGVGRKTANVVMNVAFGEPAIAVDTHIFRVCNRTGFAPGKTPAEVEEKLLKVVPK 170
Cdd:COG0177   81 IALARILVEKYGGEVPETREELESLPGVGRKTANVVLNFAFGKPAIAVDTHVHRVSNRLGLVPGKDPEEVEKDLMKLIPK 160

                        170       180       190
                 ....*....|....*....|....*....|....
gi 524144797 171 DYLLNAHHWLLLFGRYICKARNPECIRCPVAEYC 204
Cdd:COG0177  161 EYWGDLHHLLILHGRYICKARKPKCEECPLADLC 194
nth TIGR01083
endonuclease III; This equivalog model identifes nth members of the pfam00730 superfamily ...
 13-195 4.66e-107

endonuclease III; This equivalog model identifes nth members of the pfam00730 superfamily (HhH-GPD: Helix-hairpin-helix and Gly/Pro rich loop followed by a conserved aspartate). The major members of the superfamily are nth and mutY. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273434 [Multi-domain]  Cd Length: 192  Bit Score: 307.38  E-value: 4.66e-107
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 524144797   13 ALAALNPNPKSELNYSTPFELLVAVMLSAQATDKGVNLATAKLFPVANTPQKILDLGLDGLIPYVQTINLYRTKAQHLIE 92
Cdd:TIGR01083  10 RLRKNYPHPTTELDFNNPFELLVATILSAQATDKRVNKATPKLFEVYPTPQALAQAGLEELEEYIKSIGLYRNKAKNIIE 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 524144797   93 ACRILIDRFHGEVPRTRDELVSLPGVGRKTANVVMNVAFGEPAIAVDTHIFRVCNRTGFAPGKTPAEVEEKLLKVVPKDY 172
Cdd:TIGR01083  90 LCRKLVERYGGEVPEDREELVKLPGVGRKTANVVLNVAFGIPAIAVDTHVFRVSNRLGLSKGKDPIKVEEDLMKLVPREF 169

                         170       180
                  ....*....|....*....|...
gi 524144797  173 LLNAHHWLLLFGRYICKARNPEC 195
Cdd:TIGR01083 170 WVKLHHWLILHGRYTCKARKPLC 192
PRK10702 PRK10702
endonuclease III; Provisional
 6-209 1.17e-97

endonuclease III; Provisional


Pssm-ID: 182661 [Multi-domain]  Cd Length: 211  Bit Score: 284.22  E-value: 1.17e-97
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 524144797   6 NREPFMAALAAL---NPNPKSELNYSTPFELLVAVMLSAQATDKGVNLATAKLFPVANTPQKILDLGLDGLIPYVQTINL 82
Cdd:PRK10702   2 NKAKRLEILTRLrdnNPHPTTELNFSSPFELLIAVLLSAQATDVSVNKATAKLYPVANTPAAMLELGVEGVKTYIKTIGL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 524144797  83 YRTKAQHLIEACRILIDRFHGEVPRTRDELVSLPGVGRKTANVVMNVAFGEPAIAVDTHIFRVCNRTGFAPGKTPAEVEE 162
Cdd:PRK10702  82 YNSKAENVIKTCRILLEQHNGEVPEDRAALEALPGVGRKTANVVLNTAFGWPTIAVDTHIFRVCNRTQFAPGKNVEQVEE 161

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 524144797 163 KLLKVVPKDYLLNAHHWLLLFGRYICKARNPECIRCPVAEYCSAPEK 209
Cdd:PRK10702 162 KLLKVVPAEFKVDCHHWLILHGRYTCIARKPRCGSCIIEDLCEYKEK 208
ENDO3c cd00056
endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), ...
 31-184 5.42e-52

endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases


Pssm-ID: 238013 [Multi-domain]  Cd Length: 158  Bit Score: 166.26  E-value: 5.42e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 524144797  31 FELLVAVMLSAQATDKGVNLATAKLFP-VANTPQKILDLGLDGLIPYVQTINlYRTKAQHLIEACRILIDRFHGEV---P 106
Cdd:cd00056    1 FEVLVSEILSQQTTDKAVNKAYERLFErYGPTPEALAAADEEELRELIRSLG-YRRKAKYLKELARAIVEGFGGLVlddP 79

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 524144797 107 RTRDELVSLPGVGRKTANVVMNVAFGEPAIAVDTHIFRVCNRTGFAP-GKTPAEVEEKLLKVVPKDYLLNAHHWLLLFG 184
Cdd:cd00056   80 DAREELLALPGVGRKTANVVLLFALGPDAFPVDTHVRRVLKRLGLIPkKKTPEELEELLEELLPKPYWGEANQALMDLG 158
ENDO3c smart00478
endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), ...
 39-186 4.63e-51

endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases


Pssm-ID: 214684 [Multi-domain]  Cd Length: 149  Bit Score: 163.59  E-value: 4.63e-51
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 524144797    39 LSAQATDKGVNLATAKLFPVANTPQKILDLGLDGLIPYVQTINLYRTKAQHLIEACRILIDRFHGEVPRTRDELVSLPGV 118
Cdd:smart00478   1 LSQQTTDERVNKATERLFEKFPTPEDLAAADEEELEELIRGLGFYRRKARYLIELARILVEEYGGEVPDDREELLKLPGV 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 524144797   119 GRKTANVVMNVAFGEPAIAVDTHIFRVCNRTGFAPGK-TPAEVEEKLLKVVPKDYLLNAHHWLLLFGRY 186
Cdd:smart00478  81 GRKTANAVLSFALGKPFIPVDTHVLRIAKRLGLVDKKsTPEEVEKLLEKLLPEEDWRELNLLLIDFGRT 149
HhH-GPD pfam00730
HhH-GPD superfamily base excision DNA repair protein; This family contains a diverse range of ...
 35-170 1.61e-40

HhH-GPD superfamily base excision DNA repair protein; This family contains a diverse range of structurally related DNA repair proteins. The superfamily is called the HhH-GPD family after its hallmark Helix-hairpin-helix and Gly/Pro rich loop followed by a conserved aspartate. This includes endonuclease III, EC:4.2.99.18 and MutY an A/G-specific adenine glycosylase, both have a C terminal 4Fe-4S cluster. The family also includes 8-oxoguanine DNA glycosylases. The methyl-CPG binding protein MBD4 also contains a related domain that is a thymine DNA glycosylase. The family also includes DNA-3-methyladenine glycosylase II EC:3.2.2.21 and other members of the AlkA family.


Pssm-ID: 425841 [Multi-domain]  Cd Length: 141  Bit Score: 136.26  E-value: 1.61e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 524144797   35 VAVMLSAQATDKGVNLATAKLF-PVANTPQKILDLGLDGLIPYVQTINLYRTKAQHLIEACRILIDRFHGEVPRTRDELV 113
Cdd:pfam00730   1 VSAILSQQTSDKAVNKITERLFeKFFPTPEDLADADEEELRELIRGLGFYRRKAKYLKELARILVEGYGGEVPLDEEELE 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 524144797  114 S-LPGVGRKTANVVMNVAFG--EPAIAVDTHIFRVCNRTGFAPG-KTPAEVEEKLLKVVPK 170
Cdd:pfam00730  81 AlLKGVGRWTAEAVLIFALGrpDPLPVVDTHVRRVLKRLGLIKEkPTPKEVERELEELWPP 141
 
Name Accession Description Interval E-value
Nth COG0177
Endonuclease III [Replication, recombination and repair];
11-204 2.43e-118

Endonuclease III [Replication, recombination and repair];


Pssm-ID: 439947 [Multi-domain]  Cd Length: 198  Bit Score: 335.91  E-value: 2.43e-118
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 524144797  11 MAALAALNPNPKSELNYSTPFELLVAVMLSAQATDKGVNLATAKLFPVANTPQKILDLGLDGLIPYVQTINLYRTKAQHL 90
Cdd:COG0177    1 LERLKELYPDAKTELDYRDPFELLVATILSAQTTDERVNKATPRLFARYPTPEALAAADLEELEELIRPIGLYRNKAKNI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 524144797  91 IEACRILIDRFHGEVPRTRDELVSLPGVGRKTANVVMNVAFGEPAIAVDTHIFRVCNRTGFAPGKTPAEVEEKLLKVVPK 170
Cdd:COG0177   81 IALARILVEKYGGEVPETREELESLPGVGRKTANVVLNFAFGKPAIAVDTHVHRVSNRLGLVPGKDPEEVEKDLMKLIPK 160

                        170       180       190
                 ....*....|....*....|....*....|....
gi 524144797 171 DYLLNAHHWLLLFGRYICKARNPECIRCPVAEYC 204
Cdd:COG0177  161 EYWGDLHHLLILHGRYICKARKPKCEECPLADLC 194
nth TIGR01083
endonuclease III; This equivalog model identifes nth members of the pfam00730 superfamily ...
 13-195 4.66e-107

endonuclease III; This equivalog model identifes nth members of the pfam00730 superfamily (HhH-GPD: Helix-hairpin-helix and Gly/Pro rich loop followed by a conserved aspartate). The major members of the superfamily are nth and mutY. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273434 [Multi-domain]  Cd Length: 192  Bit Score: 307.38  E-value: 4.66e-107
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 524144797   13 ALAALNPNPKSELNYSTPFELLVAVMLSAQATDKGVNLATAKLFPVANTPQKILDLGLDGLIPYVQTINLYRTKAQHLIE 92
Cdd:TIGR01083  10 RLRKNYPHPTTELDFNNPFELLVATILSAQATDKRVNKATPKLFEVYPTPQALAQAGLEELEEYIKSIGLYRNKAKNIIE 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 524144797   93 ACRILIDRFHGEVPRTRDELVSLPGVGRKTANVVMNVAFGEPAIAVDTHIFRVCNRTGFAPGKTPAEVEEKLLKVVPKDY 172
Cdd:TIGR01083  90 LCRKLVERYGGEVPEDREELVKLPGVGRKTANVVLNVAFGIPAIAVDTHVFRVSNRLGLSKGKDPIKVEEDLMKLVPREF 169

                         170       180
                  ....*....|....*....|...
gi 524144797  173 LLNAHHWLLLFGRYICKARNPEC 195
Cdd:TIGR01083 170 WVKLHHWLILHGRYTCKARKPLC 192
PRK10702 PRK10702
endonuclease III; Provisional
 6-209 1.17e-97

endonuclease III; Provisional


Pssm-ID: 182661 [Multi-domain]  Cd Length: 211  Bit Score: 284.22  E-value: 1.17e-97
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 524144797   6 NREPFMAALAAL---NPNPKSELNYSTPFELLVAVMLSAQATDKGVNLATAKLFPVANTPQKILDLGLDGLIPYVQTINL 82
Cdd:PRK10702   2 NKAKRLEILTRLrdnNPHPTTELNFSSPFELLIAVLLSAQATDVSVNKATAKLYPVANTPAAMLELGVEGVKTYIKTIGL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 524144797  83 YRTKAQHLIEACRILIDRFHGEVPRTRDELVSLPGVGRKTANVVMNVAFGEPAIAVDTHIFRVCNRTGFAPGKTPAEVEE 162
Cdd:PRK10702  82 YNSKAENVIKTCRILLEQHNGEVPEDRAALEALPGVGRKTANVVLNTAFGWPTIAVDTHIFRVCNRTQFAPGKNVEQVEE 161

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 524144797 163 KLLKVVPKDYLLNAHHWLLLFGRYICKARNPECIRCPVAEYCSAPEK 209
Cdd:PRK10702 162 KLLKVVPAEFKVDCHHWLILHGRYTCIARKPRCGSCIIEDLCEYKEK 208
ENDO3c cd00056
endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), ...
 31-184 5.42e-52

endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases


Pssm-ID: 238013 [Multi-domain]  Cd Length: 158  Bit Score: 166.26  E-value: 5.42e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 524144797  31 FELLVAVMLSAQATDKGVNLATAKLFP-VANTPQKILDLGLDGLIPYVQTINlYRTKAQHLIEACRILIDRFHGEV---P 106
Cdd:cd00056    1 FEVLVSEILSQQTTDKAVNKAYERLFErYGPTPEALAAADEEELRELIRSLG-YRRKAKYLKELARAIVEGFGGLVlddP 79

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 524144797 107 RTRDELVSLPGVGRKTANVVMNVAFGEPAIAVDTHIFRVCNRTGFAP-GKTPAEVEEKLLKVVPKDYLLNAHHWLLLFG 184
Cdd:cd00056   80 DAREELLALPGVGRKTANVVLLFALGPDAFPVDTHVRRVLKRLGLIPkKKTPEELEELLEELLPKPYWGEANQALMDLG 158
ENDO3c smart00478
endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), ...
 39-186 4.63e-51

endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases


Pssm-ID: 214684 [Multi-domain]  Cd Length: 149  Bit Score: 163.59  E-value: 4.63e-51
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 524144797    39 LSAQATDKGVNLATAKLFPVANTPQKILDLGLDGLIPYVQTINLYRTKAQHLIEACRILIDRFHGEVPRTRDELVSLPGV 118
Cdd:smart00478   1 LSQQTTDERVNKATERLFEKFPTPEDLAAADEEELEELIRGLGFYRRKARYLIELARILVEEYGGEVPDDREELLKLPGV 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 524144797   119 GRKTANVVMNVAFGEPAIAVDTHIFRVCNRTGFAPGK-TPAEVEEKLLKVVPKDYLLNAHHWLLLFGRY 186
Cdd:smart00478  81 GRKTANAVLSFALGKPFIPVDTHVLRIAKRLGLVDKKsTPEEVEKLLEKLLPEEDWRELNLLLIDFGRT 149
HhH-GPD pfam00730
HhH-GPD superfamily base excision DNA repair protein; This family contains a diverse range of ...
 35-170 1.61e-40

HhH-GPD superfamily base excision DNA repair protein; This family contains a diverse range of structurally related DNA repair proteins. The superfamily is called the HhH-GPD family after its hallmark Helix-hairpin-helix and Gly/Pro rich loop followed by a conserved aspartate. This includes endonuclease III, EC:4.2.99.18 and MutY an A/G-specific adenine glycosylase, both have a C terminal 4Fe-4S cluster. The family also includes 8-oxoguanine DNA glycosylases. The methyl-CPG binding protein MBD4 also contains a related domain that is a thymine DNA glycosylase. The family also includes DNA-3-methyladenine glycosylase II EC:3.2.2.21 and other members of the AlkA family.


Pssm-ID: 425841 [Multi-domain]  Cd Length: 141  Bit Score: 136.26  E-value: 1.61e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 524144797   35 VAVMLSAQATDKGVNLATAKLF-PVANTPQKILDLGLDGLIPYVQTINLYRTKAQHLIEACRILIDRFHGEVPRTRDELV 113
Cdd:pfam00730   1 VSAILSQQTSDKAVNKITERLFeKFFPTPEDLADADEEELRELIRGLGFYRRKAKYLKELARILVEGYGGEVPLDEEELE 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 524144797  114 S-LPGVGRKTANVVMNVAFG--EPAIAVDTHIFRVCNRTGFAPG-KTPAEVEEKLLKVVPK 170
Cdd:pfam00730  81 AlLKGVGRWTAEAVLIFALGrpDPLPVVDTHVRRVLKRLGLIKEkPTPKEVERELEELWPP 141
HP0602 COG2231
3-Methyladenine DNA glycosylase, HhH-GPD/Endo3 superfamily [Replication, recombination and ...
 29-204 2.82e-23

3-Methyladenine DNA glycosylase, HhH-GPD/Endo3 superfamily [Replication, recombination and repair];


Pssm-ID: 441832 [Multi-domain]  Cd Length: 220  Bit Score: 93.76  E-value: 2.82e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 524144797  29 TPFELLVAVMLsAQATD-KGV-----NLATAKLFpvanTPQKILDLGLDGLIPYVQTINLYRTKAQHLIEACRILIDRFH 102
Cdd:COG2231   28 TPFEVIVGAIL-TQNTSwKNVekaiaNLKEAGLL----DPEALAALDPEELAELIRPSGFYNQKAKRLKNLARWLVERYG 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 524144797 103 GEVPRT--------RDELVSLPGVGRKTANVVMNVAFGEPAIAVDTHIFRVCNRTGFAPGKTP-AEVEEKLLKVVPKD-Y 172
Cdd:COG2231  103 GGLEKLkalpteelREELLSLKGIGPETADSILLYAFNRPVFVVDAYTRRIFSRLGLIEEDASyDELQRLFEENLPPDvA 182

                        170       180       190
                 ....*....|....*....|....*....|...
gi 524144797 173 LLNAHHWLLL-FGRYICKARnPECIRCPVAEYC 204
Cdd:COG2231  183 LYNEFHALIVeHGKEYCKKK-PKCEECPLRDLC 214
MutY COG1194
Adenine-specific DNA glycosylase, acts on AG and A-oxoG pairs [Replication, recombination and ...
 87-206 1.14e-18

Adenine-specific DNA glycosylase, acts on AG and A-oxoG pairs [Replication, recombination and repair];


Pssm-ID: 440807 [Multi-domain]  Cd Length: 350  Bit Score: 83.65  E-value: 1.14e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 524144797  87 AQHLIEACRILIDRFHGEVPRTRDELVSLPGVGRKTANVVMNVAFGEPAIAVDTHIFRVcnrtgFA--------PGKTPA 158
Cdd:COG1194   85 ARNLHKAAQQVVEEHGGVFPDTYEELLALPGIGPYTAAAIASIAFGEPAPIVDGNVKRV-----LSrlfaiegpIGSPAA 159

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 524144797 159 E--VEEKLLKVVPKDyllNAHHW---LLLFGRYICKARNPECIRCPVAEYCSA 206
Cdd:COG1194  160 KkeLWALAEELLPPE---RPGDFnqaLMDLGATVCTPKKPKCLLCPLQDDCAA 209
PRK10880 PRK10880
adenine DNA glycosylase;
83-206 3.12e-12

adenine DNA glycosylase;


Pssm-ID: 182805 [Multi-domain]  Cd Length: 350  Bit Score: 65.12  E-value: 3.12e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 524144797  83 YRTKAQHLIEACRILIDRFHGEVPRTRDELVSLPGVGRKTANVVMNVAFGEPAIAVDTHIFRVCNR----TGFaPGKTpa 158
Cdd:PRK10880  82 YYARARNLHKAAQQVATLHGGEFPETFEEVAALPGVGRSTAGAILSLSLGKHFPILDGNVKRVLARcyavSGW-PGKK-- 158

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 524144797 159 EVEEKLL----KVVPKDYLLNAHHWLLLFGRYICKARNPECIRCPVAEYCSA 206
Cdd:PRK10880 159 EVENRLWqlseQVTPAVGVERFNQAMMDLGAMVCTRSKPKCELCPLQNGCIA 210
PRK13910 PRK13910
DNA glycosylase MutY; Provisional
 83-209 6.21e-10

DNA glycosylase MutY; Provisional


Pssm-ID: 172427 [Multi-domain]  Cd Length: 289  Bit Score: 58.11  E-value: 6.21e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 524144797  83 YRTKAQHLIEACRILIDRFHGEVPRTRDELVSLPGVGRKTANVVMNVAFGEPAIAVDTHIFRVCNRT-GFAPGKTPAEVE 161
Cdd:PRK13910  45 YYSRAKNLKKSAEICVKEHHSQLPNDYQSLLKLPGIGAYTANAILCFGFREKSACVDANIKRVLLRLfGLDPNIHAKDLQ 124

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 524144797 162 EKLLKVVPKDYLLNAHHWLLLFGRYICKARnPECIRCPVAEYC---SAPEK 209
Cdd:PRK13910 125 IKANDFLNLNESFNHNQALIDLGALICSPK-PKCAICPLNPYClgkNNPEK 174
HHH pfam00633
Helix-hairpin-helix motif; The helix-hairpin-helix DNA-binding motif is found to be duplicated ...
 100-129 4.17e-08

Helix-hairpin-helix motif; The helix-hairpin-helix DNA-binding motif is found to be duplicated in the central domain of RuvA. The HhH domain of DisA, a bacterial checkpoint control protein, is a DNA-binding domain.


Pssm-ID: 425789 [Multi-domain]  Cd Length: 30  Bit Score: 47.80  E-value: 4.17e-08
                          10        20        30
                  ....*....|....*....|....*....|
gi 524144797  100 RFHGEVPRTRDELVSLPGVGRKTANVVMNV 129
Cdd:pfam00633   1 SLEGLIPASVEELLALPGVGPKTAEAILSY 30
AlkA COG0122
3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [Replication, recombination and ...
 29-142 6.48e-08

3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [Replication, recombination and repair];


Pssm-ID: 439892 [Multi-domain]  Cd Length: 255  Bit Score: 51.81  E-value: 6.48e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 524144797  29 TPFELLVAVMLSAQatdkgVNLATAK----------------------LFPvanTPQKILDLGLDGLipyvQTINLYRTK 86
Cdd:COG0122   83 DPFEALVRAILGQQ-----VSVAAARtiwrrlvalfgepiegpggglyAFP---TPEALAAASEEEL----RACGLSRRK 150

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 524144797  87 AQHLIEACR------ILIDRFHG-EVPRTRDELVSLPGVGRKTANVVMNVAFGEPAI--AVDTHI 142
Cdd:COG0122  151 ARYLRALARavadgeLDLEALAGlDDEEAIARLTALPGIGPWTAEMVLLFALGRPDAfpAGDLGL 215
EndIII_4Fe-2S pfam10576
Iron-sulfur binding domain of endonuclease III; Escherichia coli endonuclease III (EC 4.2.99. ...
 188-204 2.09e-04

Iron-sulfur binding domain of endonuclease III; Escherichia coli endonuclease III (EC 4.2.99.18) is a DNA repair enzyme that acts both as a DNA N-glycosylase, removing oxidized pyrimidines from DNA, and as an apurinic/apyrimidinic (AP) endonuclease, introducing a single-strand nick at the site from which the damaged base was removed. Endonuclease III is an iron-sulfur protein that binds a single 4Fe-4S cluster. The 4Fe-4S cluster does not seem to be important for catalytic activity, but is probably involved in the proper positioning of the enzyme along the DNA strand. The 4Fe-4S cluster is bound by four cysteines which are all located in a 17 amino acid region at the C-terminal end of endonuclease III. A similar region is also present in the central section of mutY and in the C-terminus of ORF-10 and of the Micro-coccus UV endonuclease.


Pssm-ID: 463153 [Multi-domain]  Cd Length: 17  Bit Score: 37.37  E-value: 2.09e-04
                          10
                  ....*....|....*..
gi 524144797  188 CKARNPECIRCPVAEYC 204
Cdd:pfam10576   1 CTARKPKCEECPLADLC 17
ogg TIGR00588
8-oxoguanine DNA-glycosylase (ogg); All proteins in this family for which functions are known ...
 83-148 1.84e-03

8-oxoguanine DNA-glycosylase (ogg); All proteins in this family for which functions are known are 8-oxo-guanaine DNA glycosylases that function in base excision repair. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). This family is distantly realted to the Nth-MutY superfamily. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 211589 [Multi-domain]  Cd Length: 310  Bit Score: 38.74  E-value: 1.84e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 524144797   83 YRtkAQHLIEACRILIDRFHG----------EVPRTRDELVSLPGVGRKTANVVMNVAFGEP-AIAVDTHIFRVCNR 148
Cdd:TIGR00588 185 YR--ARYIRETARALLEEQGGrawlqqirgaSYEDAREALCELPGVGPKVADCICLMGLDKPqAVPVDVHVWRIANR 259
FES smart00525
iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); ...
 187-206 2.87e-03

iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3);


Pssm-ID: 197771 [Multi-domain]  Cd Length: 21  Bit Score: 34.45  E-value: 2.87e-03
                           10        20
                   ....*....|....*....|
gi 524144797   187 ICKARNPECIRCPVAEYCSA 206
Cdd:smart00525   1 ICTARKPRCDECPLKDLCPA 20
PRK13913 PRK13913
3-methyladenine DNA glycosylase; Provisional
 63-151 2.87e-03

3-methyladenine DNA glycosylase; Provisional


Pssm-ID: 184390  Cd Length: 218  Bit Score: 37.91  E-value: 2.87e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 524144797  63 QKILDLGLDGLIPYVQTINLYRTKAQHLIEACR-ILID-----RFHGEVprTRDELVSLPGVGRKTANVVMNVAFGEPAI 136
Cdd:PRK13913  70 KKIAYIEFSKLAECVRPSGFYNQKAKRLIDLSEnILKDfgsfeNFKQEV--TREWLLDQKGIGKESADAILCYVCAKEVM 147

                         90
                 ....*....|....*
gi 524144797 137 AVDTHIFRVCNRTGF 151
Cdd:PRK13913 148 VVDKYSYLFLKKLGI 162
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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