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Conserved domains on  [gi|524511116|emb|CDC49691|]
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amine acid ABC transporter permease protein 3-TM region His/Glu/Gln/Arg/opine family [Clostridium sp. CAG:58]

Protein Classification

amino acid ABC transporter permease( domain architecture ID 11433582)

amino acid ABC transporter permease is the transmembrane (TM) subunit of a periplasmic binding protein (PBP)-dependent ATP-binding cassette (ABC) transporter which binds and transports amino acids

Gene Ontology:  GO:0140359|GO:0042626|GO:0006865
PubMed:  25750732|24638992
TCDB:  3.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HisM COG0765
ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; ...
 10-227 2.68e-80

ABC-type amino acid transport system, permease component [Amino acid transport and metabolism];


:

Pssm-ID: 440528 [Multi-domain]  Cd Length: 218  Bit Score: 239.59  E-value: 2.68e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 524511116  10 VWTEYSSLFLHGLWMTLYMGALTVLISTVSGSLMAMMHRSswgigRFKPLHAAAVVYVEVIRGTPILLQLYFFYFMLPQW 89
Cdd:COG0765    7 VLLDYLPLLLEGLLVTLLLTVLAIVLGLVLGLLLALARLS-----PNPVLRWLATAYVEFFRGTPLLVQLFFIYFGLPLL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 524511116  90 fpALDLSEFTCVMIACCVNSTAYVCEIVRAGIQAVDAGQTEAARSLGLNSRQAMIHIVLPQAVKNILPALCNEFVAIVKE 169
Cdd:COG0765   82 --GIDLSPFVAAVIALTLNSAAYLAEIVRAGIQSVPKGQWEAARALGLSRWQTMRRIILPQALRIILPPLGNEFISLLKD 159

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 524511116 170 TSLASTFFIGELMTQFKTINGITFRVLEPLTIVGIIYFLVTFVMSKLIALLERRMNAS 227
Cdd:COG0765  160 TSLVSVIGVPELTRAAQQIASRTFRPFEVYLVAALIYLVLTLPLSLLARRLERRLARG 217
 
Name Accession Description Interval E-value
HisM COG0765
ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; ...
 10-227 2.68e-80

ABC-type amino acid transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 440528 [Multi-domain]  Cd Length: 218  Bit Score: 239.59  E-value: 2.68e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 524511116  10 VWTEYSSLFLHGLWMTLYMGALTVLISTVSGSLMAMMHRSswgigRFKPLHAAAVVYVEVIRGTPILLQLYFFYFMLPQW 89
Cdd:COG0765    7 VLLDYLPLLLEGLLVTLLLTVLAIVLGLVLGLLLALARLS-----PNPVLRWLATAYVEFFRGTPLLVQLFFIYFGLPLL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 524511116  90 fpALDLSEFTCVMIACCVNSTAYVCEIVRAGIQAVDAGQTEAARSLGLNSRQAMIHIVLPQAVKNILPALCNEFVAIVKE 169
Cdd:COG0765   82 --GIDLSPFVAAVIALTLNSAAYLAEIVRAGIQSVPKGQWEAARALGLSRWQTMRRIILPQALRIILPPLGNEFISLLKD 159

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 524511116 170 TSLASTFFIGELMTQFKTINGITFRVLEPLTIVGIIYFLVTFVMSKLIALLERRMNAS 227
Cdd:COG0765  160 TSLVSVIGVPELTRAAQQIASRTFRPFEVYLVAALIYLVLTLPLSLLARRLERRLARG 217
PRK15100 PRK15100
cystine ABC transporter permease;
17-229 1.53e-40

cystine ABC transporter permease;


Pssm-ID: 185055 [Multi-domain]  Cd Length: 220  Bit Score: 138.34  E-value: 1.53e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 524511116  17 LFLHGLWMTLYMGALTVLISTVSGSLMAMMHRSswgigRFKPLHAAAVVYVEVIRGTPILLQLYFFYFMLPQWfpALDLS 96
Cdd:PRK15100  14 FLLKGAGYTLQLSIGGMFFGLLLGFILALMRLS-----PIWPVRWLARFYVSIFRGTPLIAQLFMIYYGLPQF--GIELD 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 524511116  97 EFTCVMIACCVNSTAYVCEIVRAGIQAVDAGQTEAARSLGLNSRQAMIHIVLPQAVKNILPALCNEFVAIVKETSLASTF 176
Cdd:PRK15100  87 PIPAAMIGLSLNTAAYAAETLRAAISSIDKGQWEAAASIGMTRWQTLRRAILPQAARTALPPLSNSFISLVKDTSLAATI 166

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 524511116 177 FIGELMTQFKTINGITFRVLEPLTIVGIIYFLVTFVMSKLIALLERRMNASER 229
Cdd:PRK15100 167 QVPELFRQAQLITSRTLEVFTMYLAASLIYWIMATVLSALQNRFENQLNRQER 219
ectoine_ehuD TIGR03003
ectoine/hydroxyectoine ABC transporter, permease protein EhuD; Members of this family are ...
 19-224 7.00e-39

ectoine/hydroxyectoine ABC transporter, permease protein EhuD; Members of this family are presumed to act as permease subunits of ectoine ABC transporters. Operons containing this gene also contain the other genes of the ABC transporter and typically are found next to either ectoine utilization or ectoine biosynthesis operons.


Pssm-ID: 132048 [Multi-domain]  Cd Length: 212  Bit Score: 133.82  E-value: 7.00e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 524511116   19 LHGLWMTLYMGALTVLISTVSGSLMAMMHRSswgigRFKPLHAAAVVYVEVIRGTPILLQLYFFYFMLPQWfpALDLSEF 98
Cdd:TIGR03003  14 IEGLKITILATALGFAIAAVLGLVFAILRRS-----APTPISWPTSFVVEFIRGTPLLVQLYFLYYVLPDI--GIRLPAL 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 524511116   99 TCVMIACCVNSTAYVCEIVRAGIQAVDAGQTEAARSLGLNSRQAMIHIVLPQAVKNILPALCNEFVAIVKETSLASTFFI 178
Cdd:TIGR03003  87 VAGVLGLGLHYATYAAEVYRAGIEAVPRGQWEAATALNLTARQTYRHIILPQAIPPIIPALGNYLVAMFKETPVLSAITV 166

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 524511116  179 GELMTQFKTINGITFRVLEPLTIVGIIYFLVTFVMSKLIALLERRM 224
Cdd:TIGR03003 167 LELMNQAKSIGNSTFRYLEPMTLVGVFFLILSIISVFFLRRLEARL 212
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 22-214 9.22e-18

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 78.09  E-value: 9.22e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 524511116  22 LWMTLYMGALTVLISTVSGSLMAMMHRSSWGIGRfkplhAAAVVYVEVIRGTPILLQLYFFYFMLPQ-WFPALDLSEFTC 100
Cdd:cd06261    1 LLNTLLLALIATLLALVLGLLLGIILARKRGKLD-----RLLRRIIDLLLSLPSLVLGLLLVLLFGVlLGWGILPGLGLP 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 524511116 101 VMIACCVNSTAYVCEIVRAGIQAVDAGQTEAARSLGLNSRQAMIHIVLPQAVKNILPALCNEFVAIVKETSLASTFFIGE 180
Cdd:cd06261   76 ALILALLLIAPFARLIRRAALESIPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARALGEFALVSFLGGGE 155

                        170       180       190
                 ....*....|....*....|....*....|....
gi 524511116 181 LMTQFKTINGITFRVLEPLTIVGIIYFLVTFVMS 214
Cdd:cd06261  156 APGPGTGLLLIFAILFPGDLGVAAAVALILLLLS 189
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 52-224 5.90e-13

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 64.63  E-value: 5.90e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 524511116   52 GIGRFKPLHAAAVVYVEVIRGTPILLQLY-FFYFMLPQWFPALDLSeftcVMIACCVNSTAYVCEIVRAGIQAVDAGQTE 130
Cdd:pfam00528   9 ALRRGRRLDRLLRPLIDLLQALPSFVLAIlLVVIAILSILGHGILP----AIILALLGWAGYARLIRRAALRSLPSDLVE 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 524511116  131 AARSLGLNSRQAMIHIVLPQAVKNILPALCNEFVAIVKETSLASTFF----IGELMTQFKTINGITFRvLEPLTIVGIIY 206
Cdd:pfam00528  85 AARALGASRWQIFRKIILPNALPPILTGLALAFGGALGGAVLLEFLGswpgLGLLLIEAILGYDYPEI-QGPVLAAALIL 163

                         170
                  ....*....|....*...
gi 524511116  207 FLVTFVMSKLIALLERRM 224
Cdd:pfam00528 164 LLLNLLVDILQRLLDPRV 181
 
Name Accession Description Interval E-value
HisM COG0765
ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; ...
 10-227 2.68e-80

ABC-type amino acid transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 440528 [Multi-domain]  Cd Length: 218  Bit Score: 239.59  E-value: 2.68e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 524511116  10 VWTEYSSLFLHGLWMTLYMGALTVLISTVSGSLMAMMHRSswgigRFKPLHAAAVVYVEVIRGTPILLQLYFFYFMLPQW 89
Cdd:COG0765    7 VLLDYLPLLLEGLLVTLLLTVLAIVLGLVLGLLLALARLS-----PNPVLRWLATAYVEFFRGTPLLVQLFFIYFGLPLL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 524511116  90 fpALDLSEFTCVMIACCVNSTAYVCEIVRAGIQAVDAGQTEAARSLGLNSRQAMIHIVLPQAVKNILPALCNEFVAIVKE 169
Cdd:COG0765   82 --GIDLSPFVAAVIALTLNSAAYLAEIVRAGIQSVPKGQWEAARALGLSRWQTMRRIILPQALRIILPPLGNEFISLLKD 159

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 524511116 170 TSLASTFFIGELMTQFKTINGITFRVLEPLTIVGIIYFLVTFVMSKLIALLERRMNAS 227
Cdd:COG0765  160 TSLVSVIGVPELTRAAQQIASRTFRPFEVYLVAALIYLVLTLPLSLLARRLERRLARG 217
PRK15100 PRK15100
cystine ABC transporter permease;
17-229 1.53e-40

cystine ABC transporter permease;


Pssm-ID: 185055 [Multi-domain]  Cd Length: 220  Bit Score: 138.34  E-value: 1.53e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 524511116  17 LFLHGLWMTLYMGALTVLISTVSGSLMAMMHRSswgigRFKPLHAAAVVYVEVIRGTPILLQLYFFYFMLPQWfpALDLS 96
Cdd:PRK15100  14 FLLKGAGYTLQLSIGGMFFGLLLGFILALMRLS-----PIWPVRWLARFYVSIFRGTPLIAQLFMIYYGLPQF--GIELD 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 524511116  97 EFTCVMIACCVNSTAYVCEIVRAGIQAVDAGQTEAARSLGLNSRQAMIHIVLPQAVKNILPALCNEFVAIVKETSLASTF 176
Cdd:PRK15100  87 PIPAAMIGLSLNTAAYAAETLRAAISSIDKGQWEAAASIGMTRWQTLRRAILPQAARTALPPLSNSFISLVKDTSLAATI 166

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 524511116 177 FIGELMTQFKTINGITFRVLEPLTIVGIIYFLVTFVMSKLIALLERRMNASER 229
Cdd:PRK15100 167 QVPELFRQAQLITSRTLEVFTMYLAASLIYWIMATVLSALQNRFENQLNRQER 219
ectoine_ehuD TIGR03003
ectoine/hydroxyectoine ABC transporter, permease protein EhuD; Members of this family are ...
 19-224 7.00e-39

ectoine/hydroxyectoine ABC transporter, permease protein EhuD; Members of this family are presumed to act as permease subunits of ectoine ABC transporters. Operons containing this gene also contain the other genes of the ABC transporter and typically are found next to either ectoine utilization or ectoine biosynthesis operons.


Pssm-ID: 132048 [Multi-domain]  Cd Length: 212  Bit Score: 133.82  E-value: 7.00e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 524511116   19 LHGLWMTLYMGALTVLISTVSGSLMAMMHRSswgigRFKPLHAAAVVYVEVIRGTPILLQLYFFYFMLPQWfpALDLSEF 98
Cdd:TIGR03003  14 IEGLKITILATALGFAIAAVLGLVFAILRRS-----APTPISWPTSFVVEFIRGTPLLVQLYFLYYVLPDI--GIRLPAL 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 524511116   99 TCVMIACCVNSTAYVCEIVRAGIQAVDAGQTEAARSLGLNSRQAMIHIVLPQAVKNILPALCNEFVAIVKETSLASTFFI 178
Cdd:TIGR03003  87 VAGVLGLGLHYATYAAEVYRAGIEAVPRGQWEAATALNLTARQTYRHIILPQAIPPIIPALGNYLVAMFKETPVLSAITV 166

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 524511116  179 GELMTQFKTINGITFRVLEPLTIVGIIYFLVTFVMSKLIALLERRM 224
Cdd:TIGR03003 167 LELMNQAKSIGNSTFRYLEPMTLVGVFFLILSIISVFFLRRLEARL 212
glnP PRK09494
glutamine ABC transporter permease protein; Reviewed
 17-224 1.21e-36

glutamine ABC transporter permease protein; Reviewed


Pssm-ID: 181907 [Multi-domain]  Cd Length: 219  Bit Score: 128.25  E-value: 1.21e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 524511116  17 LFLHGLWMTLYMGALTVLISTVSGSLMAMMHRSSWGIgrfkpLHAAAVVYVEVIRGTPILLQLYFFYFMLPQWFPALDLS 96
Cdd:PRK09494  14 LLLEGAKMTLWISVLGLAGGLVIGLLAGFARAYGGWI-----ANHIALVFIELIRGTPIVVQVMFIYFALPMAFNDLRID 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 524511116  97 EFTCVMIACCVNSTAYVCEIVRAGIQAVDAGQTEAARSLGLNSRQAMIHIVLPQAVKNILPALCNEFVAIVKETSLASTF 176
Cdd:PRK09494  89 PFTAAVVTIMINSGAYIAEITRGAVLSIHKGFREAGLALGLSRRETLRYVIGPLALRRMLPPLGNQWIISIKDTSLFIVI 168

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 524511116 177 FIGELMTQFKTINGITFRVLEPLTIVGIIYFLVTFVMSKLIALLERRM 224
Cdd:PRK09494 169 GVAELTRQGQEIIAGNFRALEIWSAVAVIYLIITLVLSFILRRLERRM 216
ectoine_ehuC TIGR03004
ectoine/hydroxyectoine ABC transporter, permease protein EhuC; Members of this family are ...
 12-224 6.35e-31

ectoine/hydroxyectoine ABC transporter, permease protein EhuC; Members of this family are presumed to act as permease subunits of ectoine ABC transporters. Operons containing this gene also contain the other genes of the ABC transporter and typically are found next to either ectoine utilization or ectoine biosynthesis operons. Permease subunits EhuC and EhuD are homologous.


Pssm-ID: 132049 [Multi-domain]  Cd Length: 214  Bit Score: 113.02  E-value: 6.35e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 524511116   12 TEYSSLFLHGLWMTLYMgaltvlisTVSGSLMAMMHRSSWGIGR---FKPLHAAAVVYVEVIRGTPILLQLYFFYFMLPq 88
Cdd:TIGR03004   1 TAYLPLLLQGAWVTMQI--------TLAGSVLATVLAFFAGLGRvsgGPILRTVALCYIEVFRGTSLLVQLFWFYFVLP- 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 524511116   89 wFPALDLSEFTCVMIACCVNSTAYVCEIVRAGIQAVDAGQTEAARSLGLNSRQAMIHIVLPQAVKNILPALCNEFVAIVK 168
Cdd:TIGR03004  72 -LIGLSLDPVTTGVMVLGLHAGAYGAEIVRGALSSVSVQQLEACRALNFTRFQTLRRISLPQALVEMMPAFGNLAIELLK 150

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 524511116  169 ETSLASTFFIGELMTQFKTINGITFRVLEPLTIVGIIYFLVTFVMSKLIALLERRM 224
Cdd:TIGR03004 151 LTSLVSLISLADLTFAAQSIRNLTLDTLSIFAITLLCYFVMALIIMLIMRVLERVV 206
artM PRK11122
arginine ABC transporter permease ArtM;
13-229 2.64e-26

arginine ABC transporter permease ArtM;


Pssm-ID: 182978 [Multi-domain]  Cd Length: 222  Bit Score: 101.19  E-value: 2.64e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 524511116  13 EYSSLFLHGLWMTLYMGALTVLISTVSGSLMAMMHrsswgIGRFKPLHAAAVVYVEVIRGTPILLQLYFFYFMlPQWFPA 92
Cdd:PRK11122   3 EYLPELLKGLHTSLTLTVASLLVALVLALIFTIIL-----TLKTPVLVWLVRGYITLFTGTPLLVQIFLIYYG-PGQFPW 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 524511116  93 LD--------LSE-FTCVMIACCVNSTAYVCEIVRAGIQAVDAGQTEAARSLGLNSRQAMiHIVLPQAVKNILPALCNEF 163
Cdd:PRK11122  77 LQeypwlwhlLSQpWLCAMLALALNSAAYSTQLFYGAVRAIPEGQWQSCAALGMSKKQTL-RILLPYAFKRALSSYSNEV 155

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 524511116 164 VAIVKETSLASTFFIGELMTQFKTINGITFRVLePLTIVGIIYFLVTFVMSKLIALLERRMNASER 229
Cdd:PRK11122 156 VLVFKSTSLAYTITLMDVMGYSQLLYGRTYDVM-VFGAAGIIYLVVNGLLTLLMRLIERKALAFER 220
PRK11123 PRK11123
arginine ABC transporter permease ArtQ;
12-229 6.84e-24

arginine ABC transporter permease ArtQ;


Pssm-ID: 182979 [Multi-domain]  Cd Length: 238  Bit Score: 95.51  E-value: 6.84e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 524511116  12 TEYSSLfLHGLWMTLYMGaltvLISTVSGSLMAMMHrSSWGIGRFKPLHAAAVVYVEVIRGTPILLQLYFFYFMLPQ--- 88
Cdd:PRK11123   2 NEFFPL-ASAAGMTVGLA----VCALIVGLALAMLF-AVWESAKWRPVAWPGTALVTLLRGLPEILVVLFIYFGSSQlll 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 524511116  89 -------------------WFPALDLSEFTCVMIACCVNSTAYVCEIVRAGIQAVDAGQTEAARSLGLNSRQAMIHIVLP 149
Cdd:PRK11123  76 tlsdgftlnlgfvqipvqmDIENFEVSPFLCGVIALSLLYAAYASQTLRGALKAVPVGQWESGQALGLSKSAIFFRLVMP 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 524511116 150 QAVKNILPALCNEFVAIVKETSLASTFFIGELMTQFKTINGitfRVLEPLT---IVGIIYFLVTFVMSKLIALLERRMNA 226
Cdd:PRK11123 156 QMWRHALPGLGNQWLVLLKDTALVSLISVNDLMLQTKSIAT---RTQEPFTwyiIAAAIYLVITLISQYILKRIELRATR 232


                 ...
gi 524511116 227 SER 229
Cdd:PRK11123 233 FER 235
PRK15107 PRK15107
glutamate/aspartate ABC transporter permease GltK;
19-223 3.14e-22

glutamate/aspartate ABC transporter permease GltK;


Pssm-ID: 185062 [Multi-domain]  Cd Length: 224  Bit Score: 90.66  E-value: 3.14e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 524511116  19 LHGLWMTLYMGALTVLISTVSGSLMAMMHRSSwgigrFKPLHAAAVVYVEVIRGTPILLQLYFFYFMLPQWFP-ALDLSE 97
Cdd:PRK15107  17 LDGLVITLKITVTAVVIGILWGTILAVMRLSS-----FKPVAWFAKAYVNVFRSIPLVMVLLWFYLIVPGFLQnVLGLSP 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 524511116  98 FTCV-----MIACCVNSTAYVCEIVRAGIQAVDAGQTEAARSLGLNSRQAMIHIVLPQAVKNILPALCNEFVAIVKETSL 172
Cdd:PRK15107  92 KTDIrlisaMVAFSMFEAAYYSEIIRAGIQSISRGQSSAALALGMTHWQSMKLIILPQAFRAMVPLLLTQGIVLFQDTSL 171

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 524511116 173 ASTFFIGELMTQFKTINGITFRVLEPLTIVGIIYFLVTFVMSKLIALLERR 223
Cdd:PRK15107 172 VYVLSLADFFRTASTIGERDGTQVEMILFAGFVYFVISLSASLLVSYLKKR 222
BatB COG4597
ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; ...
 14-229 1.21e-21

ABC-type amino acid transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 443651 [Multi-domain]  Cd Length: 397  Bit Score: 91.75  E-value: 1.21e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 524511116  14 YSSLFLHGLWMTLYMGALTVLISTVSGSLMAMMHRSS-WGIGRFkplhaaAVVYVEVIRGTPILLQLYFFYFM------- 85
Cdd:COG4597   84 YGRAFLVGLLNTLLVAVLGIVLATILGFLVGIARLSSnWLVSKL------ATVYVEIFRNIPLLLQIFFWYFAvlealps 157

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 524511116  86 ------------------------------------------------------------LPQWFPALDL---------- 95
Cdd:COG4597  158 prqslslfdgvflnnrglylpapvfepgfgwvlaallaaivaafvlrrwarrrqeatgqrFPVWWISLALlvglpllafl 237

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 524511116  96 -------------------------SEFTCVMIACCVNSTAYVCEIVRAGIQAVDAGQTEAARSLGLNSRQAMIHIVLPQ 150
Cdd:COG4597  238 llgaplsldypelkgfnfrggltlsPEFVALLLALSLYTAAFIAEIVRAGIQAVSKGQTEAARALGLRPGQTLRLVVLPQ 317

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 524511116 151 AVKNILPALCNEFVAIVKETSLAstFFIG--ELMTQF-KTINGITFRVLEPLTIVGIIYFLVTFVMSKLIALLERRMNAS 227
Cdd:COG4597  318 ALRVIIPPLTSQYLNLTKNSSLA--VAIGypDLVSVFaGTTLNQTGQAIEIIAITMAVYLTISLLISLLMNWYNRRVALV 395


                 ..
gi 524511116 228 ER 229
Cdd:COG4597  396 ER 397
HEQRo_perm_3TM TIGR01726
amine acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family; This ...
 17-119 1.44e-21

amine acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family; This model represents one of several classes of multiple membrane spanning regions found immediately N-terminal to the domain described by pfam00528, binding-protein-dependent transport systems inner membrane component. The region covered by this model generally is predicted to contain three transmembrane helices. Substrate specificities attributed to members of this family include histidine, arginine, glutamine, glutamate, and (in Agrobacterium) the opines octopine and nopaline. [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 130787 [Multi-domain]  Cd Length: 99  Bit Score: 85.28  E-value: 1.44e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 524511116   17 LFLHGLWMTLYMGALTVLISTVSGSLMAMMHRSswgigRFKPLHAAAVVYVEVIRGTPILLQLYFFYFMLPQWFpaLDLS 96
Cdd:TIGR01726   4 FLLKGLLLTLLLSVLSILLGLVLGLLLALLRLS-----GNRPLRWIATVYVELFRGTPLLVQLFFIYFGLPLIG--IRLS 76

                          90       100
                  ....*....|....*....|...
gi 524511116   97 EFTCVMIACCVNSTAYVCEIVRA 119
Cdd:TIGR01726  77 PLTAAVIALTLFYGAYLAEIFRG 99
PRK15069 PRK15069
histidine ABC transporter permease HisM;
19-223 5.20e-20

histidine ABC transporter permease HisM;


Pssm-ID: 185029 [Multi-domain]  Cd Length: 234  Bit Score: 85.10  E-value: 5.20e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 524511116  19 LHGLWMTLYMGALTVLISTVSGSLMAMMHRSSWgigrfKPLHAAAVVYVEVIRGTPILLQLYFFYFML--------PQWF 90
Cdd:PRK15069  20 FTGLAITLWLLVASVVIGFVLAVPLAIARVSSN-----KWIRFPVWLYTYVFRGTPLYVQLLVFYTGMysleivrgTDLL 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 524511116  91 PALDLSEFTCVMIACCVNSTAYVCEIVRAGIQAVDAGQTEAARSLGLNSRQAMIHIVLPQAVKNILPALCNEFVAIVKET 170
Cdd:PRK15069  95 DAFFRSGLNCTILAFTLNTCAYTTEIFAGAIRSVPHGEIEAARAYGMSTFKLYRRIILPSALRRALPAYSNEVILMLHAT 174

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 524511116 171 SLASTFFIGELMTQFKTINGITFRVLEPLTIVGIIYFLVTFVMSKLIALLERR 223
Cdd:PRK15069 175 TLAFTATVPDILKIARDINSATYQPFQAFGIAAVLYLIISFVLISLFRRAERR 227
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 22-214 9.22e-18

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 78.09  E-value: 9.22e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 524511116  22 LWMTLYMGALTVLISTVSGSLMAMMHRSSWGIGRfkplhAAAVVYVEVIRGTPILLQLYFFYFMLPQ-WFPALDLSEFTC 100
Cdd:cd06261    1 LLNTLLLALIATLLALVLGLLLGIILARKRGKLD-----RLLRRIIDLLLSLPSLVLGLLLVLLFGVlLGWGILPGLGLP 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 524511116 101 VMIACCVNSTAYVCEIVRAGIQAVDAGQTEAARSLGLNSRQAMIHIVLPQAVKNILPALCNEFVAIVKETSLASTFFIGE 180
Cdd:cd06261   76 ALILALLLIAPFARLIRRAALESIPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARALGEFALVSFLGGGE 155

                        170       180       190
                 ....*....|....*....|....*....|....
gi 524511116 181 LMTQFKTINGITFRVLEPLTIVGIIYFLVTFVMS 214
Cdd:cd06261  156 APGPGTGLLLIFAILFPGDLGVAAAVALILLLLS 189
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 52-224 5.90e-13

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 64.63  E-value: 5.90e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 524511116   52 GIGRFKPLHAAAVVYVEVIRGTPILLQLY-FFYFMLPQWFPALDLSeftcVMIACCVNSTAYVCEIVRAGIQAVDAGQTE 130
Cdd:pfam00528   9 ALRRGRRLDRLLRPLIDLLQALPSFVLAIlLVVIAILSILGHGILP----AIILALLGWAGYARLIRRAALRSLPSDLVE 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 524511116  131 AARSLGLNSRQAMIHIVLPQAVKNILPALCNEFVAIVKETSLASTFF----IGELMTQFKTINGITFRvLEPLTIVGIIY 206
Cdd:pfam00528  85 AARALGASRWQIFRKIILPNALPPILTGLALAFGGALGGAVLLEFLGswpgLGLLLIEAILGYDYPEI-QGPVLAAALIL 163

                         170
                  ....*....|....*...
gi 524511116  207 FLVTFVMSKLIALLERRM 224
Cdd:pfam00528 164 LLLNLLVDILQRLLDPRV 181
TauC COG0600
ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion ...
 15-224 2.88e-09

ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440365 [Multi-domain]  Cd Length: 254  Bit Score: 55.54  E-value: 2.88e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 524511116  15 SSLFLHGLWMTLYMGALTVLISTVSGSLMAMMhrsswgIGRFKPLHAAAVVYVEVIRGTPILLqlYFFYFMLpqWFPALD 94
Cdd:COG0600   56 SGELWEHLLASLLRVLLGFALAALLGVPLGLL------LGLSRLLRRLLDPLLVFLRPIPPLA--LAPLLIL--WFGIGE 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 524511116  95 LSEFTCVMIACcvnsTAYVCEIVRAGIQAVDAGQTEAARSLGLNSRQAMIHIVLPQAVKNILPALCNEF-----VAIVKE 169
Cdd:COG0600  126 ASKIFVIFLGA----FFPILLNTAAGVRSVDPELLELARSLGASRWQILRKVVLPAALPYIFTGLRIALglawiGLVVAE 201

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 524511116 170 TsLASTFFIGELMTQFKTingiTFRVlePLTIVGIIYF-LVTFVMSKLIALLERRM 224
Cdd:COG0600  202 L-LGASSGLGYLILDARQ----LLDT--DLVFAAILVIgLLGLLLDLLLRLLERRL 250
PRK15135 PRK15135
histidine ABC transporter permease HisQ;
14-223 4.66e-09

histidine ABC transporter permease HisQ;


Pssm-ID: 185089 [Multi-domain]  Cd Length: 228  Bit Score: 54.80  E-value: 4.66e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 524511116  14 YSSLFLHGLWMTLYMGALTVLISTVSGSLMAMMHRSSwgigrFKPLHAAAVVYVEVIRGTP-ILLQLYFFY---FMLPQW 89
Cdd:PRK15135   5 FSGVILQGALVTLELALSSVVLAVIIGLIGAGGKLSQ-----NRLLGLIFEGYTTLIRGVPdLVLMLLIFYglqIALNSV 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 524511116  90 FPALDLSEF-----TCVMIACCVNSTAYVCEIVRAGIQAVDAGQTEAARSLGLNSRQAMIHIVLPQAVKNILPALCNEFV 164
Cdd:PRK15135  80 TEALGVGQIdidpmVAGIITLGFIYGAYFTETFRGAFMAVPKGHIEAATAFGFTRGQVFRRIMFPAMMRYALPGIGNNWQ 159

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 524511116 165 AIVKETSLASTFFIGELMTQFKTINGITFRVLEPLTIVGIIYFLVTFVMSKLIALLERR 223
Cdd:PRK15135 160 VILKATALVSLLGLEDVVKATQLAGKSTWEPFYFAIVCGVIYLVFTTVSNGVLLWLERR 218
PotC COG1177
ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport ...
 18-159 1.47e-07

ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism];


Pssm-ID: 440790 [Multi-domain]  Cd Length: 262  Bit Score: 50.50  E-value: 1.47e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 524511116  18 FLHGLWMTLYMGALTVLISTVSGSLMAmmhrssWGIGRFKPLHAAAVVYV--------EVIRGTPILLqlyFFYFMlpqw 89
Cdd:COG1177   59 LLDALLNSLLIALLSTLLATVLGTPAA------LALARYRFRGRRLLLALlllplvvpGIVLGVALLL---LFSAL---- 125

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 524511116  90 fpALDLSeFTCVMIACCVNSTAYVCEIVRAGIQAVDAGQTEAARSLGLNSRQAMIHIVLPqavkNILPAL 159
Cdd:COG1177  126 --GLSGG-LWGLILAHVVFTLPFVVLVVLARLQGFDPSLEEAARDLGASPWQTFRRVTLP----LIAPGI 188
FbpB COG1178
ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];
15-176 4.54e-05

ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440791 [Multi-domain]  Cd Length: 538  Bit Score: 43.61  E-value: 4.54e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 524511116  15 SSLFLHGLWMTLYMGALTVLISTVSGSLMAMMHRSSWGIGRfKPLHAAAVVyvevIRGTP-ILLQLYFFYFMLPQWFPAL 93
Cdd:COG1178  333 DPSLLRALLNSLLLALLAALLAVLLALLLAYLVRRRRGRLA-RLLDRLAML----PYAVPgIVLGLGLLLLFNRPLPLLL 407

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 524511116  94 DLSeFTCVMIACCVNSTAYVCEIVRAGIQAVDAGQTEAARSLGLNSRQAMIHIVLPQAVKNILPALCNEFVAIVKETSLA 173
Cdd:COG1178  408 YGT-LAILVLAYVVRFLPFALRSLEAALAQIDPSLEEAARSLGASPLRTLRRVTLPLLRPGLLAAALLVFVTSMKELSAT 486


                 ...
gi 524511116 174 STF 176
Cdd:COG1178  487 LLL 489
FbpB COG1178
ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];
15-159 8.92e-04

ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440791 [Multi-domain]  Cd Length: 538  Bit Score: 39.76  E-value: 8.92e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 524511116  15 SSLFLHGLWMTLYMGALTVLISTVSGSLMAmmhrssWGIGRFK-----------------PLHAAAVVYVEVIRGTPILL 77
Cdd:COG1178   49 DPYLWRALGNTLLLALLVTLLSLLLGVPLA------WLLARTDfpgrrllrwllllplalPPYVVALAWIALFGPNGLLN 122

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 524511116  78 QLYFFYFMLPQWfpalDLSEFTCVMIACCVNSTAYVCEIVRAGIQAVDAGQTEAARSLGLNSRQAMIHIVLPQAvkniLP 157
Cdd:COG1178  123 TLLRALFGLEPP----DIYGLGGIILVLVLFNYPYVYLLLRAALRSIDASLEEAARSLGASPWRAFRRVTLPLL----RP 194


                 ..
gi 524511116 158 AL 159
Cdd:COG1178  195 AI 196
UgpA COG1175
ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism];
15-150 4.33e-03

ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism];


Pssm-ID: 440788 [Multi-domain]  Cd Length: 298  Bit Score: 37.42  E-value: 4.33e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 524511116  15 SSLFLHGLWMTLYMGALTVLISTVSGSLMA-MMHRSSWGIGRFKplhaaAVVYVEVIrgTPILLQLYFFYFML------- 86
Cdd:COG1175   71 DPRFWNALGNTLLFTVVSVPLQLVLGLLLAlLLNRKLRGRGFFR-----TLFFLPWV--ISPVVVALIWKWLFnpdygll 143

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 524511116  87 -----------PQWFPALDLSeFTCVMIACCVNSTAYVCEIVRAGIQAVDAGQTEAARSLGLNSRQAMIHIVLPQ 150
Cdd:COG1175  144 nallgalglepINWLGDPSLA-LPAVIIVTVWKGTGFNMLIFLAGLQSIPRELYEAARIDGASPWQRFRRITLPL 217
CysU COG0555
ABC-type sulfate transport system, permease component [Inorganic ion transport and metabolism]; ...
 15-156 8.34e-03

ABC-type sulfate transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440321 [Multi-domain]  Cd Length: 268  Bit Score: 36.65  E-value: 8.34e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 524511116  15 SSLFLHGLWMTLYMGALTVLISTVSGSLMAmmhrssWGIGR----FKPLhaaavvyVEVIRGTPI----------LLQLY 80
Cdd:COG0555   49 SPRVLAALKLSLGTALIAALINLVFGLPLA------WVLVRyrfpGKRL-------VDALVDLPFalptavagiaLLLLF 115

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 524511116  81 FFYFMLPQWFPALDLS---EFTCVMIACCVNSTAYVCEIVRAGIQAVDAGQTEAARSLGLNSRQAMIHIVLPQAVKNIL 156
Cdd:COG0555  116 GPNGWLGQLLAPLGIKvafTPLGIVLAQTFVSLPFVVRTVQPVLEELDPELEEAAATLGASRWQTFRRVILPLLLPALL 194
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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