|
Name |
Accession |
Description |
Interval |
E-value |
| BaeS |
COG0642 |
Signal transduction histidine kinase [Signal transduction mechanisms]; |
437-770 |
3.20e-82 |
|
Signal transduction histidine kinase [Signal transduction mechanisms];
Pssm-ID: 440407 [Multi-domain] Cd Length: 328 Bit Score: 265.62 E-value: 3.20e-82
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 437 AARPVVERRVADPDQSGLSRTTEVQLADDRWLQINERRTRDGGLVSVGTDITLLKRHQERLRDSERRLMATIGDLSASQH 516
Cdd:COG0642 1 LLLLLLLLVLLLLLLLLLLLALLLLLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 517 KLERQKTELSDANANYLAEKERAQAANRAKSEFLANMSHELRTPLNAILGFSEILLNEmfgpvGSPKYSEYARDIHDSGK 596
Cdd:COG0642 81 LLLLLLLLLLLLLLLLLALLLLLEEANEAKSRFLANVSHELRTPLTAIRGYLELLLEE-----LDEEQREYLETILRSAD 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 597 HLLNVINDILDMSKIEAGHMRINRETIDLAPLIEETLRLTAIQAEQKNITVQQKVCAGL-TMQGDRRAMKQIMLNLLSNA 675
Cdd:COG0642 156 RLLRLINDLLDLSRLEAGKLELEPEPVDLAELLEEVVELFRPLAEEKGIELELDLPDDLpTVRGDPDRLRQVLLNLLSNA 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 676 VKFTGDGGSIALRTHVHEAAMILTIADTGIGIPTQALEKIGQPFEQVQSqyAKSQGGSGLGLAISRSLVKLHGGTMKIRS 755
Cdd:COG0642 236 IKYTPEGGTVTVSVRREGDRVRISVEDTGPGIPPEDLERIFEPFFRTDP--SRRGGGTGLGLAIVKRIVELHGGTIEVES 313
|
330
....*....|....*
gi 549125420 756 CEGRGTVVTIIIPHA 770
Cdd:COG0642 314 EPGKGTTFTVTLPLA 328
|
|
| KdpD |
COG2205 |
K+-sensing histidine kinase KdpD [Signal transduction mechanisms]; |
534-771 |
3.40e-78 |
|
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 251.36 E-value: 3.40e-78
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 534 AEKERAQAANRAKSEFLANMSHELRTPLNAILGFSEILLNEmfGPVGSPKYSEYARDIHDSGKHLLNVINDILDMSKIEA 613
Cdd:COG2205 4 EALEELEELERLKSEFLANVSHELRTPLTSILGAAELLLDE--EDLSPEERRELLEIIRESAERLLRLIEDLLDLSRLES 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 614 GHMRINRETIDLAPLIEETLRLTAIQAEQKNITVQQKVCAGLTM-QGDRRAMKQIMLNLLSNAVKFTGDGGSIALRTHVH 692
Cdd:COG2205 82 GKLSLELEPVDLAELLEEAVEELRPLAEEKGIRLELDLPPELPLvYADPELLEQVLANLLDNAIKYSPPGGTITISARRE 161
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 549125420 693 EAAMILTIADTGIGIPTQALEKIGQPFEQVQSqyAKSQGGSGLGLAISRSLVKLHGGTMKIRSCEGRGTVVTIIIPHAA 771
Cdd:COG2205 162 GDGVRISVSDNGPGIPEEELERIFERFYRGDN--SRGEGGTGLGLAIVKRIVEAHGGTIWVESEPGGGTTFTVTLPLAE 238
|
|
| WalK |
COG5002 |
Sensor histidine kinase WalK [Signal transduction mechanisms]; |
431-770 |
1.38e-73 |
|
Sensor histidine kinase WalK [Signal transduction mechanisms];
Pssm-ID: 444026 [Multi-domain] Cd Length: 390 Bit Score: 244.85 E-value: 1.38e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 431 STVYAAAARPVVERRVADPDQSGLSRTTEVQLADDRWLQINERRTRDGGLVSVGTDITLLKRHQERLRDSERRLMATIGD 510
Cdd:COG5002 47 LLLLLLALLLLLLLLLLLLLALLLLLLLLLLLLALALLLLALLLLLLLLLLLLALLILLLLLALLILLAALLLLLSELLL 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 511 LSASQHKLERQKTELSDANANYLAEK---ERAQAANRAKSEFLANMSHELRTPLNAILGFSEILLNEMFGPvgSPKYSEY 587
Cdd:COG5002 127 LLLLLGRLSLRLSALLLGLLLLAAVErdiTELERLEQMRREFVANVSHELRTPLTSIRGYLELLLDGAADD--PEERREY 204
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 588 ARDIHDSGKHLLNVINDILDMSKIEAGHMRINRETIDLAPLIEETLRLTAIQAEQKNITVQQKVCAG-LTMQGDRRAMKQ 666
Cdd:COG5002 205 LEIILEEAERLSRLVNDLLDLSRLESGELKLEKEPVDLAELLEEVVEELRPLAEEKGIELELDLPEDpLLVLGDPDRLEQ 284
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 667 IMLNLLSNAVKFTGDGGSIALRTHVHEAAMILTIADTGIGIPTQALEKIGQPFEQVQSQYAKSQGGSGLGLAISRSLVKL 746
Cdd:COG5002 285 VLTNLLDNAIKYTPEGGTITVSLREEDDQVRISVRDTGIGIPEEDLPRIFERFYRVDKSRSRETGGTGLGLAIVKHIVEA 364
|
330 340
....*....|....*....|....
gi 549125420 747 HGGTMKIRSCEGRGTVVTIIIPHA 770
Cdd:COG5002 365 HGGRIWVESEPGKGTTFTITLPLA 388
|
|
| KinE |
COG5809 |
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ... |
274-768 |
1.13e-57 |
|
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444511 [Multi-domain] Cd Length: 489 Bit Score: 204.44 E-value: 1.13e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 274 FDLSTRRMFWSGSLYEILGMPPKAtpLSFSDAARMMHSED-GNLYELARAVGCGNLRQiDQIFRMRHTKGHYVWLRARAQ 352
Cdd:COG5809 31 LDLEGKILKVNPAAERIFGYTEDE--LLGTNILDFLHPDDeKELREILKLLKEGESRD-ELEFELRHKNGKRLEFSSKLS 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 353 VIRTNNGPRV--IGIAMDVTEQHRLAQRYAEADQRLADAIESTSEAFVLWDKNDRLVMCNTHYQKAYGLPDSVLVAGTek 430
Cdd:COG5809 108 PIFDQNGDIEgmLAISRDITERKRMEEALRESEEKFRLIFNHSPDGIIVTDLDGRIIYANPAACKLLGISIEELIGKS-- 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 431 stvYAAAARPVVERRVADPDQSGLSRTTEVQLADDRWLQINERR---------TRDG---GLVSVGTDITLLKRHQERLR 498
Cdd:COG5809 186 ---ILELIHSDDQENVAAFISQLLKDGGIAQGEVRFWTKDGRWRlleasgapiKKNGevdGIVIIFRDITERKKLEELLR 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 499 DSERrlMATIGdlsasqhklerqktelsdananylaekeraqaanraksEFLANMSHELRTPLNAILGFSEILLNEMFGp 578
Cdd:COG5809 263 KSEK--LSVVG--------------------------------------ELAAGIAHEIRNPLTSLKGFIQLLKDTIDE- 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 579 vgspKYSEYARDIHDSGKHLLNVINDILDMSKIEAGHMrinrETIDLAPLIEETLRLTAIQAEQKNITVQQKVCAGLTM- 657
Cdd:COG5809 302 ----EQKTYLDIMLSELDRIESIISEFLVLAKPQAIKY----EPKDLNTLIEEVIPLLQPQALLKNVQIELELEDDIPDi 373
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 658 QGDRRAMKQIMLNLLSNAVKFTGDGGSIALRTHVHE-AAMILTIADTGIGIPTQALEKIGQPFeqvqsqYAKSQGGSGLG 736
Cdd:COG5809 374 LGDENQLKQVFINLLKNAIEAMPEGGNITIETKAEDdDKVVISVTDEGCGIPEERLKKLGEPF------YTTKEKGTGLG 447
|
490 500 510
....*....|....*....|....*....|..
gi 549125420 737 LAISRSLVKLHGGTMKIRSCEGRGTVVTIIIP 768
Cdd:COG5809 448 LMVSYKIIEEHGGKITVESEVGKGTTFSITLP 479
|
|
| TMAO_torS |
TIGR02956 |
TMAO reductase sytem sensor TorS; This protein, TorS, is part of a regulatory system for the ... |
490-772 |
1.64e-54 |
|
TMAO reductase sytem sensor TorS; This protein, TorS, is part of a regulatory system for the torCAD operon that encodes the pterin molybdenum cofactor-containing enzyme trimethylamine-N-oxide (TMAO) reductase (TorA), a cognate chaperone (TorD), and a penta-haem cytochrome (TorC). TorS works together with the inducer-binding protein TorT and the response regulator TorR. TorS contains histidine kinase ATPase (pfam02518), HAMP (pfam00672), phosphoacceptor (pfam00512), and phosphotransfer (pfam01627) domains and a response regulator receiver domain (pfam00072). [Signal transduction, Two-component systems]
Pssm-ID: 274362 [Multi-domain] Cd Length: 968 Bit Score: 203.47 E-value: 1.64e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 490 LKRHQERLrdsERRLMATIGDLSASQHKLerqktelsdaNANYLA-EKERAQA--ANRAKSEFLANMSHELRTPLNAILG 566
Cdd:TIGR02956 418 LQEHKESL---EQLVAQRTQELAETNERL----------NAEVKNhAKARAEAeeANRAKSAFLATMSHEIRTPLNGILG 484
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 567 FSEILLNEMFgpvgSPKYSEYARDIHDSGKHLLNVINDILDMSKIEAGHMRINRETIDLAPLIEETLRLTAIQAEQKNIT 646
Cdd:TIGR02956 485 TLELLGDTGL----TSQQQQYLQVINRSGESLLDILNDILDYSKIEAGHLSISPRPFDLNALLDDVHHLMVSRAQLKGIQ 560
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 647 VQQKVCAGL--TMQGDRRAMKQIMLNLLSNAVKFTgDGGSIALRTHVH-EAAMILTIADTGIGIPTQALEKIGQPFEQVQ 723
Cdd:TIGR02956 561 LRLNIPEQLpnWWQGDGPRIRQVLINLVGNAIKFT-DRGSVVLRVSLNdDSSLLFEVEDTGCGIAEEEQATLFDAFTQAD 639
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 549125420 724 SQyaKSQGGSGLGLAISRSLVKLHGGTMKIRSCEGRGTVVTIIIPHAAG 772
Cdd:TIGR02956 640 GR--RRSGGTGLGLAISQRLVEAMDGELGVESELGVGSCFWFTLPLTRG 686
|
|
| NtrY |
COG5000 |
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ... |
368-771 |
2.09e-51 |
|
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];
Pssm-ID: 444024 [Multi-domain] Cd Length: 422 Bit Score: 185.17 E-value: 2.09e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 368 DVTEQHRLAQRYAEADQRLADAI-ESTSEAFVLWDKNDRLVMCNTHYQKAYGLPDSVLVagteKSTVYAAAARPVVERRV 446
Cdd:COG5000 73 RMTDQLKEQREELEERRRYLETIlENLPAGVIVLDADGRITLANPAAERLLGIPLEELI----GKPLEELLPELDLAELL 148
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 447 ADPDQSGLSRTTEVQLADDRWLQINERRTRDGGLVSVGTDITLLKRHQErlrdserrlMATIGDLSASqhklerqktels 526
Cdd:COG5000 149 REALERGWQEEIELTRDGRRTLLVRASPLRDDGYVIVFDDITELLRAER---------LAAWGELARR------------ 207
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 527 dananylaekeraqaanrakseflanMSHELRTPLNAILGFSEILLNEM--FGPVGSPKYSEYARDIHDSGKHLLNVIND 604
Cdd:COG5000 208 --------------------------IAHEIKNPLTPIQLSAERLRRKLadKLEEDREDLERALDTIIRQVDRLKRIVDE 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 605 ILDMSKIEAghmrINRETIDLAPLIEETLRLTAIQAEQKNITVQQKVCAGL-TMQGDRRAMKQIMLNLLSNAVKFTGDGG 683
Cdd:COG5000 262 FLDFARLPE----PQLEPVDLNELLREVLALYEPALKEKDIRLELDLDPDLpEVLADRDQLEQVLINLLKNAIEAIEEGG 337
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 684 SIALRTHVHEAAMILTIADTGIGIPTQALEKIGQPFeqvqsqYAKSQGGSGLGLAISRSLVKLHGGTMKIRSCEGRGTVV 763
Cdd:COG5000 338 EIEVSTRREDGRVRIEVSDNGPGIPEEVLERIFEPF------FTTKPKGTGLGLAIVKKIVEEHGGTIELESRPGGGTTF 411
|
....*...
gi 549125420 764 TIIIPHAA 771
Cdd:COG5000 412 TIRLPLAE 419
|
|
| COG4251 |
COG4251 |
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ... |
302-768 |
2.45e-51 |
|
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];
Pssm-ID: 443393 [Multi-domain] Cd Length: 503 Bit Score: 187.30 E-value: 2.45e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 302 FSDAARMMHSEDGNLYELARAVGCGNLRQIDQIFRMRHTKGHYVWLRARAQVIRTNNGPRVIGIAMDVTEQHRLAQRYAE 381
Cdd:COG4251 49 RLLLLLLLSLLALLLLLLLLLLLLLVLAALALLLLLLLLELALVLLALLLVLLLLLALLLLLALLLLLELLLLLLALLLL 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 382 ADQRLADAIESTSEAFVLWDKNDRLVMCNThyqkAYGLPDSVLVAGTEKSTVYAAAARPVVERRVADPDQSGLSRTTEVQ 461
Cdd:COG4251 129 LLLLALLLLEELALLRLALALLLLLLLLLL----LLLLLLALILALLLAALAELELLLLLLLVLLLLLLLLLLLLLLLLR 204
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 462 LADDRWLQINERRTRDGGLVSVGTDITLLKRHQERLRDSERRLMATIGDLSASQHKLERQKTELSDANAnylaekeRAQA 541
Cdd:COG4251 205 LLLELLLLLEAELLLSLGGGLGLLLLLLLLLVLLLLLILLLLLLILVLELLELRLELEELEEELEERTA-------ELER 277
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 542 ANRAKSEFLANMSHELRTPLNAILGFSEiLLNEMFGPVGSPKYSEYARDIHDSGKHLLNVINDILDMSKIEAGHMRinRE 621
Cdd:COG4251 278 SNEELEQFAYVASHDLREPLRKISGFSQ-LLEEDYGDKLDEEGREYLERIRDAAERMQALIDDLLAYSRVGRQELE--FE 354
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 622 TIDLAPLIEETLRLTAIQAEQKNITVQqkVCAGLTMQGDRRAMKQIMLNLLSNAVKFTGDG--GSIALRTHVHEAAMILT 699
Cdd:COG4251 355 PVDLNELLEEVLEDLEPRIEERGAEIE--VGPLPTVRGDPTLLRQVFQNLISNAIKYSRPGepPRIEIGAEREGGEWVFS 432
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 549125420 700 IADTGIGIPTQALEKIGQPFEQVQSQyaKSQGGSGLGLAISRSLVKLHGGTMKIRSCEGRGTVVTIIIP 768
Cdd:COG4251 433 VRDNGIGIDPEYAEKIFEIFQRLHSR--DEYEGTGIGLAIVKKIVERHGGRIWVESEPGEGATFYFTLP 499
|
|
| PRK15347 |
PRK15347 |
two component system sensor kinase; |
533-768 |
1.40e-48 |
|
two component system sensor kinase;
Pssm-ID: 237951 [Multi-domain] Cd Length: 921 Bit Score: 185.23 E-value: 1.40e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 533 LAE-KERAQAANRAKSEFLANMSHELRTPLNAILGFSEILLNemfGPVgSPKYSEYARDIHDSGKHLLNVINDILDMSKI 611
Cdd:PRK15347 384 LAEaKQRAEQANKRKSEHLTTISHEIRTPLNGVLGALELLQN---TPL-TAEQMDLADTARQCTLSLLAIINNLLDFSRI 459
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 612 EAGHMRINRETIDLAPLIEETLRLTAIQAEQKNITVQQKVCAG--LTMQGDRRAMKQIMLNLLSNAVKFTGDGGsIALRT 689
Cdd:PRK15347 460 ESGQMTLSLEETALLPLLDQAMLTIQGPAQSKSLTLRTFVGAHvpLYLHLDSLRLRQILVNLLGNAVKFTETGG-IRLRV 538
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 549125420 690 HVHEAAMILTIADTGIGIPTQALEKIGQPFEQVQSQyaksQGGSGLGLAISRSLVKLHGGTMKIRSCEGRGTVVTIIIP 768
Cdd:PRK15347 539 KRHEQQLCFTVEDTGCGIDIQQQQQIFTPFYQADTH----SQGTGLGLTIASSLAKMMGGELTLFSTPGVGSCFSLVLP 613
|
|
| NtrB |
COG3852 |
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms]; |
380-768 |
3.26e-48 |
|
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
Pssm-ID: 443061 [Multi-domain] Cd Length: 361 Bit Score: 174.65 E-value: 3.26e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 380 AEADQRLADAIESTSEAFVLWDKNDRLVMCNTHYQKAYGLPdsvlvagtekstvyaaaARPVVERRVAD--PDQSGLSRT 457
Cdd:COG3852 3 RESEELLRAILDSLPDAVIVLDADGRITYVNPAAERLLGLS-----------------AEELLGRPLAElfPEDSPLREL 65
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 458 TEVQLADDRWLQINER--RTRDGGLVSVGTDITLLKRHqerlrDSERRLMATIGDLSAsQHKLERQktelsdananyLAE 535
Cdd:COG3852 66 LERALAEGQPVTEREVtlRRKDGEERPVDVSVSPLRDA-----EGEGGVLLVLRDITE-RKRLERE-----------LRR 128
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 536 KERAQAAnrakSEFLANMSHELRTPLNAILGFSEILLNEmfgpVGSPKYSEYARDIHDSGKHLLNVINDILDMSKIEagh 615
Cdd:COG3852 129 AEKLAAV----GELAAGLAHEIRNPLTGIRGAAQLLERE----LPDDELREYTQLIIEEADRLNNLVDRLLSFSRPR--- 197
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 616 mRINRETIDLAPLIEETLRLtaIQAE-QKNITVQQKVCAGL-TMQGDRRAMKQIMLNLLSNAVKFTGDGGSIALRTHV-- 691
Cdd:COG3852 198 -PPEREPVNLHEVLERVLEL--LRAEaPKNIRIVRDYDPSLpEVLGDPDQLIQVLLNLVRNAAEAMPEGGTITIRTRVer 274
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 692 --------HEAAMILTIADTGIGIPTQALEKIGQPFeqvqsqYAKSQGGSGLGLAISRSLVKLHGGTMKIRSCEGRGTVV 763
Cdd:COG3852 275 qvtlgglrPRLYVRIEVIDNGPGIPEEILDRIFEPF------FTTKEKGTGLGLAIVQKIVEQHGGTIEVESEPGKGTTF 348
|
....*
gi 549125420 764 TIIIP 768
Cdd:COG3852 349 RIYLP 353
|
|
| PRK11107 |
PRK11107 |
hybrid sensory histidine kinase BarA; Provisional |
506-768 |
1.09e-47 |
|
hybrid sensory histidine kinase BarA; Provisional
Pssm-ID: 236848 [Multi-domain] Cd Length: 919 Bit Score: 182.36 E-value: 1.09e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 506 ATIgDLSASQHKLERQKTELSDAnanylaeKERAQAANRAKSEFLANMSHELRTPLNAILGFSEILLNEMFgpvgSPKYS 585
Cdd:PRK11107 261 ATS-DLRETLEQMEIQNVELDLA-------KKRAQEAARIKSEFLANMSHELRTPLNGVIGFTRQTLKTPL----TPTQR 328
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 586 EYARDIHDSGKHLLNVINDILDMSKIEAGHMRInrETI--DLAPLIEETLRLTAIQAEQKN----ITVQQKVCAGLTmqG 659
Cdd:PRK11107 329 DYLQTIERSANNLLAIINDILDFSKLEAGKLVL--ENIpfSLRETLDEVVTLLAHSAHEKGleltLNIDPDVPDNVI--G 404
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 660 DRRAMKQIMLNLLSNAVKFTgDGGSIALRTHVHEAA---MIL--TIADTGIGIPTQALEKIGQPFEQVQSQYAKSQGGSG 734
Cdd:PRK11107 405 DPLRLQQIITNLVGNAIKFT-ESGNIDILVELRALSntkVQLevQIRDTGIGISERQQSQLFQAFRQADASISRRHGGTG 483
|
250 260 270
....*....|....*....|....*....|....
gi 549125420 735 LGLAISRSLVKLHGGTMKIRSCEGRGTVVTIIIP 768
Cdd:PRK11107 484 LGLVITQKLVNEMGGDISFHSQPNRGSTFWFHLP 517
|
|
| PRK11466 |
PRK11466 |
hybrid sensory histidine kinase TorS; Provisional |
503-768 |
8.17e-45 |
|
hybrid sensory histidine kinase TorS; Provisional
Pssm-ID: 236914 [Multi-domain] Cd Length: 914 Bit Score: 173.55 E-value: 8.17e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 503 RLMATIGDL----SASQHKLERQKTELSDANANYLAE---------KERAQA--ANRAKSEFLANMSHELRTPLNAILGF 567
Cdd:PRK11466 386 RELDTIGRLmdafRSNVHALNRHREQLAAQVKARTAElqelviehrQARAEAekASQAKSAFLAAMSHEIRTPLYGILGT 465
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 568 SEILLNEMFgpvgSPKYSEYARDIHDSGKHLLNVINDILDMSKIEAG--HMRINRETIDLAPLIEETLRLTAIQAEQKNI 645
Cdd:PRK11466 466 AQLLADNPA----LNAQRDDLRAITDSGESLLTILNDILDYSAIEAGgkNVSVSDEPFEPRPLLESTLQLMSGRVKGRPI 541
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 646 TVQQKVCAGL--TMQGDRRAMKQIMLNLLSNAVKFTgDGGSIALRTHVHEAAMILTIADTGIGIPTQALEKIGQPFEQVQ 723
Cdd:PRK11466 542 RLATDIADDLptALMGDPRRIRQVITNLLSNALRFT-DEGSIVLRSRTDGEQWLVEVEDSGCGIDPAKLAEIFQPFVQVS 620
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 549125420 724 SQyaksQGGSGLGLAISRSLVKLHGGTMKIRSCEGRGTVVTIIIP 768
Cdd:PRK11466 621 GK----RGGTGLGLTISSRLAQAMGGELSATSTPEVGSCFCLRLP 661
|
|
| COG4191 |
COG4191 |
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ... |
363-768 |
8.26e-44 |
|
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];
Pssm-ID: 443345 [Multi-domain] Cd Length: 361 Bit Score: 162.27 E-value: 8.26e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 363 IGIAMDVTEQHRLAQRYAEADQRLADAIESTSEAFVLWDKNDRLVMCNTHYQKAYGLPDSVLVAGTEKSTVYAAAARPVV 442
Cdd:COG4191 2 LRLLLLLLLLLALLRALALALALLLLLLLLLLALLLLLLALLLALLALLLLLLLLLLLLLLELLLLLLALLGGLLRLLLL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 443 ERRVADPDQSGLSRTTEVQLADDRWLQINERRTRDGGLVSvgtDITLLKRHQERLRDSERrlMATIGDLSASqhklerqk 522
Cdd:COG4191 82 LGLLLLLLLEALLLLLLAALDAEENAELEELERDITELER---AEEELRELQEQLVQSEK--LAALGELAAG-------- 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 523 telsdananylaekeraqaanrakseflanMSHELRTPLNAILGFSEILLNEMFGPVGSPKYSEYARDIHDSGKHLLNVI 602
Cdd:COG4191 149 ------------------------------IAHEINNPLAAILGNAELLRRRLEDEPDPEELREALERILEGAERAAEIV 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 603 NDILDMSKIEAGHmrinRETIDLAPLIEETLRLTAIQAEQKNITVQQKVCAGL-TMQGDRRAMKQIMLNLLSNAVKFTGD 681
Cdd:COG4191 199 RSLRAFSRRDEEE----REPVDLNELIDEALELLRPRLKARGIEVELDLPPDLpPVLGDPGQLEQVLLNLLINAIDAMEE 274
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 682 G--GSIALRTHVHEAAMILTIADTGIGIPTQALEKIGQPFeqvqsqY-AKSQG-GSGLGLAISRSLVKLHGGTMKIRSCE 757
Cdd:COG4191 275 GegGRITISTRREGDYVVISVRDNGPGIPPEVLERIFEPF------FtTKPVGkGTGLGLSISYGIVEKHGGRIEVESEP 348
|
410
....*....|.
gi 549125420 758 GRGTVVTIIIP 768
Cdd:COG4191 349 GGGTTFTITLP 359
|
|
| PRK11091 |
PRK11091 |
aerobic respiration control sensor protein ArcB; Provisional |
433-768 |
2.90e-42 |
|
aerobic respiration control sensor protein ArcB; Provisional
Pssm-ID: 236842 [Multi-domain] Cd Length: 779 Bit Score: 165.11 E-value: 2.90e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 433 VYAA-AARPVVERrvadpDQSGLsrTTEVQLADDRWLQINERRT------------RDG---GLVSVGTDITLLKRHQER 496
Cdd:PRK11091 203 VYSPeAAEKVIET-----DEKVF--RHNVSLTYEQWLDYPDGRKacfelrkvpfydRVGkrhGLMGFGRDITERKRYQDA 275
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 497 LrdserrlmatigdlsasqhklerqktelsdananylaEKeraqaANRAKSEFLANMSHELRTPLNAILGFSEILLNEMF 576
Cdd:PRK11091 276 L-------------------------------------EK-----ASRDKTTFISTISHELRTPLNGIVGLSRILLDTEL 313
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 577 gpvgSPKYSEYARDIHDSGKHLLNVINDILDMSKIEAGHMRINRETIDLAPLIEETLRLTAIQAEQK----NITVQQKVC 652
Cdd:PRK11091 314 ----TAEQRKYLKTIHVSAITLGNIFNDIIDMDKMERRKLQLDNQPIDFTDFLADLENLSGLQAEQKglrfDLEPLLPLP 389
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 653 AGLTMQGDRraMKQIMLNLLSNAVKFTGDGGsIALRTHVHEAAMIL-TIADTGIGIPTQALEKIGQPFEQVQSQYA-KSQ 730
Cdd:PRK11091 390 HKVITDGTR--LRQILWNLISNAVKFTQQGG-VTVRVRYEEGDMLTfEVEDSGIGIPEDELDKIFAMYYQVKDSHGgKPA 466
|
330 340 350
....*....|....*....|....*....|....*...
gi 549125420 731 GGSGLGLAISRSLVKLHGGTMKIRSCEGRGTVVTIIIP 768
Cdd:PRK11091 467 TGTGIGLAVSKRLAQAMGGDITVTSEEGKGSCFTLTIH 504
|
|
| phoR_proteo |
TIGR02966 |
phosphate regulon sensor kinase PhoR; Members of this protein family are the regulatory ... |
544-767 |
5.02e-40 |
|
phosphate regulon sensor kinase PhoR; Members of this protein family are the regulatory histidine kinase PhoR associated with the phosphate ABC transporter in most Proteobacteria. Related proteins from Gram-positive organisms are not included in this model. The phoR gene usually is adjacent to the response regulator phoB gene (TIGR02154). [Signal transduction, Two-component systems]
Pssm-ID: 274368 [Multi-domain] Cd Length: 333 Bit Score: 150.44 E-value: 5.02e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 544 RAKSEFLANMSHELRTPLNAILGFSEILLNEMfgPVGSPKYSEYARDIHDSGKHLLNVINDILDMSKIEAGHMRINRETI 623
Cdd:TIGR02966 112 QMRRDFVANVSHELRTPLTVLRGYLETLADGP--DEDPEEWNRALEIMLEQSQRMQSLVEDLLTLSRLESAASPLEDEPV 189
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 624 DLAPLIEETLRLTAIQAEQKNITVQQKVCAGLTMQGDRRAMKQIMLNLLSNAVKFTGDGGSIALRTHVHEAAMILTIADT 703
Cdd:TIGR02966 190 DMPALLDHLRDEAEALSQGKNHQITFEIDGGVDVLGDEDELRSAFSNLVSNAIKYTPEGGTITVRWRRDGGGAEFSVTDT 269
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 549125420 704 GIGIPTQALEKIGQPFEQVQSQYAKSQGGSGLGLAISRSLVKLHGGTMKIRSCEGRGTVVTIII 767
Cdd:TIGR02966 270 GIGIAPEHLPRLTERFYRVDKSRSRDTGGTGLGLAIVKHVLSRHHARLEIESELGKGSTFSFIF 333
|
|
| KinA |
COG5805 |
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ... |
269-768 |
1.59e-39 |
|
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444507 [Multi-domain] Cd Length: 496 Bit Score: 152.96 E-value: 1.59e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 269 CGLWDFDLSTRRMFWSGSLYEILGMPPKATPLSFSDAARMMHSEDGNLYELARAVGCGNLRQIDQIfrmRHTKGHYVWLR 348
Cdd:COG5805 45 DAIIAVNREGKVIYINPAMEKLLGYTSEEIIGKTIFDFLEKEYHYRVKTRIERLQKGYDVVMIEQI---YCKDGELIYVE 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 349 ARAQVIRTNNGPRVIGIAMDVTEQHRLAQRYAEADQRLADAIESTSEAFVLWDKNDRLVMCNTHYQKAYGLPDsVLVAGT 428
Cdd:COG5805 122 VKLFPIYNQNGQAAILALRDITKKKKIEEILQEQEERLQTLIENSPDLICVIDTDGRILFINESIERLFGAPR-EELIGK 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 429 EKSTVYAAAARPVVERRVADPDQSGLSRTTEVQLAD----DRWLQIN--ERRTRDG---GLVSVGTDITLLKRHQERLRD 499
Cdd:COG5805 201 NLLELLHPCDKEEFKERIESITEVWQEFIIEREIITkdgrIRYFEAVivPLIDTDGsvkGILVILRDITEKKEAEELMAR 280
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 500 SERrlMATIGDLSASqhklerqktelsdananylaekeraqaanrakseflanMSHELRTPLNAILGFSEILLNEMfgpv 579
Cdd:COG5805 281 SEK--LSIAGQLAAG--------------------------------------IAHEIRNPLTSIKGFLQLLQPGI---- 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 580 gsPKYSEYARDIHDSGKHLLNVINDILDMSKIEAghmrINRETIDLAPLIEETLRLTAIQAEQKNITVQQKVCAGL-TMQ 658
Cdd:COG5805 317 --EDKEEYFDIMLSELDRIESIISEFLALAKPQA----VNKEKENINELIQDVVTLLETEAILHNIQIRLELLDEDpFIY 390
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 659 GDRRAMKQIMLNLLSNAVKFTGDGGSIALRTHVHEAAMILTIADTGIGIPTQALEKIGQPFeqvqsqYAKSQGGSGLGLA 738
Cdd:COG5805 391 CDENQIKQVFINLIKNAIEAMPNGGTITIHTEEEDNSVIIRVIDEGIGIPEERLKKLGEPF------FTTKEKGTGLGLM 464
|
490 500 510
....*....|....*....|....*....|
gi 549125420 739 ISRSLVKLHGGTMKIRSCEGRGTVVTIIIP 768
Cdd:COG5805 465 VSYKIIENHNGTIDIDSKVGKGTTFTITLP 494
|
|
| HATPase_EvgS-ArcB-TorS-like |
cd16922 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ... |
664-768 |
6.13e-39 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340399 [Multi-domain] Cd Length: 110 Bit Score: 139.55 E-value: 6.13e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 664 MKQIMLNLLSNAVKFTgDGGSIALRTHV-----HEAAMILTIADTGIGIPTQALEKIGQPFEQVQSQYAKSQGGSGLGLA 738
Cdd:cd16922 1 LRQILLNLLGNAIKFT-EEGEVTLRVSLeeeeeDGVQLRFSVEDTGIGIPEEQQARLFEPFSQADSSTTRKYGGTGLGLA 79
|
90 100 110
....*....|....*....|....*....|
gi 549125420 739 ISRSLVKLHGGTMKIRSCEGRGTVVTIIIP 768
Cdd:cd16922 80 ISKKLVELMGGDISVESEPGQGSTFTFTLP 109
|
|
| HK_WalK |
NF033092 |
cell wall metabolism sensor histidine kinase WalK; This model describes WalK as found in ... |
548-768 |
2.55e-38 |
|
cell wall metabolism sensor histidine kinase WalK; This model describes WalK as found in Staphylococcus aureus (sp|Q2G2U4.1|WALK_STAA8). A shorter version, as found in Streptococcus pneumoniae, called WalK(Spn) or VicK, is not included. WalK is part of a two-component system and works with partner protein WalR.
Pssm-ID: 467964 [Multi-domain] Cd Length: 594 Bit Score: 151.06 E-value: 2.55e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 548 EFLANMSHELRTPLNAILGFSEILlnemfgpvgspkySEYARDIHDSGKHLLNV-----------INDILDMSKIEAGHM 616
Cdd:NF033092 374 EFVANVSHELRTPLTTMRSYLEAL-------------ADGAWKDPELAPRFLGVtqnetermirlVNDLLQLSRMDSKDY 440
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 617 RINRETIDLAPLIEETLRLTAIQAEQKNITVQQKVCAG-LTMQGDRRAMKQIMLNLLSNAVKFTGDGGSIALRTHVHEAA 695
Cdd:NF033092 441 KLNKEWVNFNEFFNYIIDRFEMILKNKNITFKREFPKRdLWVEIDTDKITQVLDNIISNAIKYSPEGGTITFRLLETHNR 520
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 549125420 696 MILTIADTGIGIPTQALEKIGQPFEQVQSQYAKSQGGSGLGLAISRSLVKLHGGTMKIRSCEGRGTVVTIIIP 768
Cdd:NF033092 521 IIISISDQGLGIPKKDLDKIFDRFYRVDKARSRKMGGTGLGLAIAKEVVEAHGGRIWAESEEGKGTTIYFTLP 593
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
659-768 |
1.72e-34 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 126.99 E-value: 1.72e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 659 GDRRAMKQIMLNLLSNAVKFTGDGGSIALRTHVHEAAMILTIADTGIGIPTQALEKIGQPFEQVqSQYAKSQGGSGLGLA 738
Cdd:smart00387 1 GDPDRLRQVLSNLLDNAIKYTPEGGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRT-DKRSRKIGGTGLGLS 79
|
90 100 110
....*....|....*....|....*....|
gi 549125420 739 ISRSLVKLHGGTMKIRSCEGRGTVVTIIIP 768
Cdd:smart00387 80 IVKKLVELHGGEISVESEPGGGTTFTITLP 109
|
|
| PRK09959 |
PRK09959 |
acid-sensing system histidine kinase EvgS; |
507-768 |
2.18e-32 |
|
acid-sensing system histidine kinase EvgS;
Pssm-ID: 182169 [Multi-domain] Cd Length: 1197 Bit Score: 135.25 E-value: 2.18e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 507 TIGDLSASQHKLE----RQKTELSDANANYLAEKERAQAANRAKSEFLANMSHELRTPLNAILGFSEILLNEmfgPVGSP 582
Cdd:PRK09959 669 TLCNLPASDHAVYicgwQDITETRDLIHALEVERNKAINATVAKSQFLATMSHEIRTPISSIMGFLELLSGS---GLSKE 745
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 583 KYSEYARDIHDSGKHLLNVINDILDMSKIEAGHMRINRETIDLAPLIEETLRLTAIQAEQKNITVQqkvCAG-----LTM 657
Cdd:PRK09959 746 QRVEAISLAYATGQSLLGLIGEILDVDKIESGNYQLQPQWVDIPTLVQNTCHSFGAIAASKSIALS---CSStfpdhYLV 822
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 658 QGDRRAMKQIMLNLLSNAVKFTGDGGSIALRTHVH----EAAMILTIADTGIGIPTQALEKIGQPFEQVQSqyAKSQGGS 733
Cdd:PRK09959 823 KIDPQAFKQVLSNLLSNALKFTTEGAVKITTSLGHiddnHAVIKMTIMDSGSGLSQEEQQQLFKRYSQTSA--GRQQTGS 900
|
250 260 270
....*....|....*....|....*....|....*
gi 549125420 734 GLGLAISRSLVKLHGGTMKIRSCEGRGTVVTIIIP 768
Cdd:PRK09959 901 GLGLMICKELIKNMQGDLSLESHPGIGTTFTITIP 935
|
|
| PRK11360 |
PRK11360 |
two-component system sensor histidine kinase AtoS; |
374-768 |
1.38e-31 |
|
two-component system sensor histidine kinase AtoS;
Pssm-ID: 236901 [Multi-domain] Cd Length: 607 Bit Score: 130.86 E-value: 1.38e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 374 RLAQRYAEADQRLADAIESTSEAFVLWDKNDRLVMCNTHYQKAYGLP---------DSVLVAGTEKSTVYAAAARPVVER 444
Cdd:PRK11360 252 NLAQALRETRSLNELILESIADGVIAIDRQGKITTMNPAAEVITGLQrhelvgkpySELFPPNTPFASPLLDTLEHGTEH 331
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 445 RVADPDQSGLSRTTEVQLADDRWlqINERRTRDGGLVSVgTDITLLKRHQERLRDSERrlMATIGdlsasqhklerqkte 524
Cdd:PRK11360 332 VDLEISFPGRDRTIELSVSTSLL--HNTHGEMIGALVIF-SDLTERKRLQRRVARQER--LAALG--------------- 391
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 525 lsdananylaekeraqaanraksEFLANMSHELRTPLNAILGFSEILLNEMFGPvGSPKY-SEYARDIhDSgkhLLNVIN 603
Cdd:PRK11360 392 -----------------------ELVAGVAHEIRNPLTAIRGYVQIWRQQTSDP-PSQEYlSVVLREV-DR---LNKVID 443
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 604 DILDMSKieAGHMRInrETIDLAPLIEETLRLTAIQAEQKNITVQQKVCAGL-TMQGDRRAMKQIMLNLLSNAVKFTGDG 682
Cdd:PRK11360 444 QLLEFSR--PRESQW--QPVSLNALVEEVLQLFQTAGVQARVDFETELDNELpPIWADPELLKQVLLNILINAVQAISAR 519
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 683 GSIALRTHVH-EAAMILTIADTGIGIPTQALEKIGQPFeqvqsqYAKSQGGSGLGLAISRSLVKLHGGTMKIRSCEGRGT 761
Cdd:PRK11360 520 GKIRIRTWQYsDGQVAVSIEDNGCGIDPELLKKIFDPF------FTTKAKGTGLGLALSQRIINAHGGDIEVESEPGVGT 593
|
....*..
gi 549125420 762 VVTIIIP 768
Cdd:PRK11360 594 TFTLYLP 600
|
|
| PRK11100 |
PRK11100 |
sensory histidine kinase CreC; Provisional |
552-771 |
1.83e-31 |
|
sensory histidine kinase CreC; Provisional
Pssm-ID: 236846 [Multi-domain] Cd Length: 475 Bit Score: 128.81 E-value: 1.83e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 552 NMSHELRTPLNAILGFSEILLNEMfgpvgSPKYSE-YARDIHDSGKHLLNVINDILDMSKIEAGHMRINRETIDLAPLIE 630
Cdd:PRK11100 262 TLTHELKSPLAAIRGAAELLQEDP-----PPEDRArFTGNILTQSARLQQLIDRLLELARLEQRQELEVLEPVALAALLE 336
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 631 ETLRLTAIQAEQKNITVQQKvCAGLTMQGDRRAMKQIMLNLLSNAVKFTGDGGSIALRTHVHEAAMILTIADTGIGIPTQ 710
Cdd:PRK11100 337 ELVEAREAQAAAKGITLRLR-PDDARVLGDPFLLRQALGNLLDNAIDFSPEGGTITLSAEVDGEQVALSVEDQGPGIPDY 415
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 549125420 711 ALEKIGQPFeqvqsqY-----AKSQGGSGLGLAISRSLVKLHGGTMKIRSCEGRGTVVTIIIPHAA 771
Cdd:PRK11100 416 ALPRIFERF------YslprpANGRKSTGLGLAFVREVARLHGGEVTLRNRPEGGVLATLTLPRHF 475
|
|
| PRK10841 |
PRK10841 |
two-component system sensor histidine kinase RcsC; |
537-768 |
4.92e-30 |
|
two-component system sensor histidine kinase RcsC;
Pssm-ID: 182772 [Multi-domain] Cd Length: 924 Bit Score: 127.40 E-value: 4.92e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 537 ERAQA---ANRAKSEFLANMSHELRTPLNAILGFSEiLLNEMFGPVGSpkyseyAR---DIHDSGKHLLNVINDILDMSK 610
Cdd:PRK10841 435 EMAQAaeqASQSKSMFLATVSHELRTPLYGIIGNLD-LLQTKELPKGV------DRlvtAMNNSSSLLLKIISDILDFSK 507
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 611 IEAGHMRIN------RETIdlAPLIEETLRLTAiqaeQKNIT----VQQKVcaGLTMQGDRRAMKQIMLNLLSNAVKFTg 680
Cdd:PRK10841 508 IESEQLKIEprefspREVI--NHITANYLPLVV----KKRLGlycfIEPDV--PVALNGDPMRLQQVISNLLSNAIKFT- 578
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 681 DGGSIALRTHVHEAAMILTIADTGIGIPTQALEKIGQPFEQVQSQYAKSQGGSGLGLAISRSLVKLHGGTMKIRSCEGRG 760
Cdd:PRK10841 579 DTGCIVLHVRVDGDYLSFRVRDTGVGIPAKEVVRLFDPFFQVGTGVQRNFQGTGLGLAICEKLINMMDGDISVDSEPGMG 658
|
....*...
gi 549125420 761 TVVTIIIP 768
Cdd:PRK10841 659 SQFTIRIP 666
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
659-768 |
7.58e-30 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 114.00 E-value: 7.58e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 659 GDRRAMKQIMLNLLSNAVKFTGDGGSIALRTHvHEAAMILTIADTGIGIPTQALEKIGQPFEQVQSqyaKSQGGSGLGLA 738
Cdd:pfam02518 1 GDELRLRQVLSNLLDNALKHAAKAGEITVTLS-EGGELTLTVEDNGIGIPPEDLPRIFEPFSTADK---RGGGGTGLGLS 76
|
90 100 110
....*....|....*....|....*....|
gi 549125420 739 ISRSLVKLHGGTMKIRSCEGRGTVVTIIIP 768
Cdd:pfam02518 77 IVRKLVELLGGTITVESEPGGGTTVTLTLP 106
|
|
| HATPase |
cd00075 |
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ... |
664-767 |
1.77e-29 |
|
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.
Pssm-ID: 340391 [Multi-domain] Cd Length: 102 Bit Score: 112.70 E-value: 1.77e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 664 MKQIMLNLLSNAVKFTGDGGSIALRTHVHEAAMILTIADTGIGIPTQALEKIGQPFEQVQSqyAKSQGGSGLGLAISRSL 743
Cdd:cd00075 1 LEQVLSNLLDNALKYSPPGGTIEISLRQEGDGVVLEVEDNGPGIPEEDLERIFERFYRGDK--SREGGGTGLGLAIVRRI 78
|
90 100
....*....|....*....|....
gi 549125420 744 VKLHGGTMKIRSCEGRGTVVTIII 767
Cdd:cd00075 79 VEAHGGRITVESEPGGGTTFTVTL 102
|
|
| BaeS_SmeS |
NF012163 |
sensor histidine kinase efflux regulator BaeS; |
490-768 |
9.10e-27 |
|
sensor histidine kinase efflux regulator BaeS;
Pssm-ID: 411086 [Multi-domain] Cd Length: 457 Bit Score: 114.54 E-value: 9.10e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 490 LKRHQERLRDSERRLMAtiGDLsasQHKLERQKT-ELSD--ANANYLAEK-ERAQAANRAkseFLANMSHELRTPLNAIL 565
Cdd:NF012163 188 LLAPVKRLVEATHRLAA--GDY---TTRVTPTSNdELGKlaQDFNQLASTlEKNEQMRRD---FMADISHELRTPLAVLR 259
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 566 GFSEIL-----------LNEMFGPVGSpkyseyardihdsgkhLLNVINDILDMSKIEAGHMRINRETIDLAPLIEETLR 634
Cdd:NF012163 260 AELEAIqdgirkftpesLDSLQAEVGT----------------LTKLVDDLHDLSMSDEGALAYQKASVDLVPLLEVEGG 323
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 635 LTAIQAEQKNITVQQKVCAGLTMQGDRRAMKQIMLNLLSNAVKFTGDGGSIALRTHVHEAAMILTIADTGIGIPTQALEK 714
Cdd:NF012163 324 AFRERFASAGLELEVSLPDSSLVFGDRDRLMQLFNNLLENSLRYTDSGGSLHISASQRPKEVTLTVADSAPGVSDEQLAR 403
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 549125420 715 IGQPFEQVQSQYAKSQGGSGLGLAISRSLVKLHGGTMKIRSCEGRGTVVTIIIP 768
Cdd:NF012163 404 LFERFYRVEVSRNRASGGSGLGLAISLNIVQAHGGTLHAAHSPLGGLRIVVTLP 457
|
|
| PRK10490 |
PRK10490 |
sensor protein KdpD; Provisional |
501-768 |
1.75e-26 |
|
sensor protein KdpD; Provisional
Pssm-ID: 236701 [Multi-domain] Cd Length: 895 Bit Score: 116.29 E-value: 1.75e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 501 ERRLMATIGDLSASqhKLERQKTELSDANANYLAEKERAQAAnrakseFLANMSHELRTPLNAILGFSEILLNEMfGPVG 580
Cdd:PRK10490 627 QQRLLETFTLLIAN--ALERLTLTASEEQARLASEREQLRNA------LLAALSHDLRTPLTVLFGQAEILTLDL-ASEG 697
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 581 SPkYSEYARDIHdsgKHLLN---VINDILDMSKIEAGHMRINRETIDLAPLIEETLRLTAIQAEQKNITVQqkVCAGLTM 657
Cdd:PRK10490 698 SP-HARQASEIR---QQVLNttrLVNNLLDMARIQSGGFNLRKEWLTLEEVVGSALQMLEPGLSGHPINLS--LPEPLTL 771
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 658 -QGDRRAMKQIMLNLLSNAVKFTGDGGSIALRTHVHEAAMILTIADTGIGIPTQALEKIGQPFEQVQSQYAKSqgGSGLG 736
Cdd:PRK10490 772 iHVDGPLFERVLINLLENAVKYAGAQAEIGIDAHVEGERLQLDVWDNGPGIPPGQEQLIFDKFARGNKESAIP--GVGLG 849
|
250 260 270
....*....|....*....|....*....|..
gi 549125420 737 LAISRSLVKLHGGTMKIRSCEGRGTVVTIIIP 768
Cdd:PRK10490 850 LAICRAIVEVHGGTIWAENRPEGGACFRVTLP 881
|
|
| PRK10364 |
PRK10364 |
two-component system sensor histidine kinase ZraS; |
480-771 |
2.32e-26 |
|
two-component system sensor histidine kinase ZraS;
Pssm-ID: 236674 [Multi-domain] Cd Length: 457 Bit Score: 113.34 E-value: 2.32e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 480 LVSVGTDITLLKRHQERlrdsERRLMATIGDLSAS-----------QHKLERQKTELSDAnanyLAEKERAQAAnrakSE 548
Cdd:PRK10364 172 AIFIAFDASNLVSAQAR----EQRNTLIILFALATvllasllaffwYRRYLRSRQLLQDE----MKRKEKLVAL----GH 239
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 549 FLANMSHELRTPLNAILGFSEillneMFG---PVGSPKYsEYARDIHDSGKHLLNVINDILDMSKieAGHMRInrETIDL 625
Cdd:PRK10364 240 LAAGVAHEIRNPLSSIKGLAK-----YFAeraPAGGEAH-QLAQVMAKEADRLNRVVSELLELVK--PTHLAL--QAVDL 309
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 626 APLIEETLRLTAIQAEQKNITVQQKVCAGL-TMQGDRRAMKQIMLNLLSNAVKFTGDGGSIALRTHVHEAAMILTIADTG 704
Cdd:PRK10364 310 NDLINHSLQLVSQDANSREIQLRFTANDTLpEIQADPDRLTQVLLNLYLNAIQAIGQHGVISVTASESGAGVKISVTDSG 389
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 549125420 705 IGIPTQALEKIGQPFEQVQSQyaksqgGSGLGLAISRSLVKLHGGTMKIRSCEGRGTVVTIIIPHAA 771
Cdd:PRK10364 390 KGIAADQLEAIFTPYFTTKAE------GTGLGLAVVHNIVEQHGGTIQVASQEGKGATFTLWLPVNI 450
|
|
| AdeS_HK |
NF012226 |
two-component sensor histidine kinase AdeS; Mutations in this component of the two-component ... |
509-768 |
4.96e-25 |
|
two-component sensor histidine kinase AdeS; Mutations in this component of the two-component regulatory system for the AdeABC efflux pump can confer adaptive resistance to certain antibiotics, including tigecycline.
Pssm-ID: 411090 [Multi-domain] Cd Length: 353 Bit Score: 107.39 E-value: 4.96e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 509 GDLSASQHKLERQKTELSDA--NANYLAEK-----ERAQAANRAkseflanMSHELRTPLNAILGFSEILLNEMFGPvgs 581
Cdd:NF012226 101 GDLSARAEDSQIHSAEISELmhNFNDMAQKlessvKNAQVWNAA-------IAHELRTPITILQGRLQGILDGVFEP--- 170
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 582 pkyseyardihDSG--KHLLN-------VINDILDMSKIEAGHMRINRETIDLAPLIEETLRLTAIQAEQKNITVQQKVC 652
Cdd:NF012226 171 -----------DPAlfKSLLNqveglshLVEDLRTLSLVENQQLRLNYESVDLKDSIEKVLKMFEDRLEQAQLTIVLNLT 239
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 653 AGLtMQGDRRAMKQIMLNLLSNAVKFTgDGGSIALRTHVHEAAMILTIADTGIGIPTQALEKIGQPFEQVQSQYAKSQGG 732
Cdd:NF012226 240 ATP-VFCDRRRIEQVLIALIDNAIRYA-NAGKLKISSSVIQDDWILQIEDEGPGIAEEYQQDLFNPFFRLEQSRNKEFGG 317
|
250 260 270
....*....|....*....|....*....|....*.
gi 549125420 733 SGLGLAISRSLVKLHGGTMKIrSCEGRGTVVTIIIP 768
Cdd:NF012226 318 TGLGLAVVHAIVIAHKGSIEY-SNSQGNSVFTIKLP 352
|
|
| cztS_silS_copS |
TIGR01386 |
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ... |
502-759 |
5.56e-25 |
|
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.
Pssm-ID: 273593 [Multi-domain] Cd Length: 457 Bit Score: 109.01 E-value: 5.56e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 502 RRLMATIGDLSASQ--HKLE--RQKTELSDANANYLAEKERAQAANRAKSEFLANMSHELRTPLNAILGFSEILLNEmfg 577
Cdd:TIGR01386 193 RRLSAVAARISPESldQRLDpsRAPAELRELAQSFNAMLGRLEDAFQRLSQFSADLAHELRTPLTNLLGQTQVALSQ--- 269
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 578 pvgsPKYSEYARDIHDSG----KHLLNVINDILDMSKIEAGHMRINRETIDLAPLIEETLRLTAIQAEQKNITVqqKVCA 653
Cdd:TIGR01386 270 ----PRTGEEYREVLESNleelERLSRMVSDMLFLARADNGQLALERVRLDLAAELAKVAEYFEPLAEERGVRI--RVEG 343
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 654 GLTMQGDRRAMKQIMLNLLSNAVKFTGDGGSIALRTHVHEAAMILTIADTGIGIPTQALEKIGQPFEQVQSQYAKSQGGS 733
Cdd:TIGR01386 344 EGLVRGDPQMFRRAISNLLSNALRHTPDGGTITVRIERRSDEVRVSVSNPGPGIPPEHLSRLFDRFYRVDPARSNSGEGT 423
|
250 260
....*....|....*....|....*.
gi 549125420 734 GLGLAISRSLVKLHGGTMKIRSCEGR 759
Cdd:TIGR01386 424 GLGLAIVRSIMEAHGGRASAESPDGK 449
|
|
| HATPase_AtoS-like |
cd16943 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
661-769 |
1.08e-22 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.
Pssm-ID: 340419 [Multi-domain] Cd Length: 105 Bit Score: 93.26 E-value: 1.08e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 661 RRAMKQIMLNLLSNAVKFTGDGGSIALRTHVHEAAMILTIADTGIGIPTQALEKIGQPFEQvqsqyAKSQG-GSGLGLAI 739
Cdd:cd16943 1 PSQLNQVLLNLLVNAAQAMEGRGRITIRTWAHVDQVLIEVEDTGSGIDPEILGRIFDPFFT-----TKPVGeGTGLGLSL 75
|
90 100 110
....*....|....*....|....*....|
gi 549125420 740 SRSLVKLHGGTMKIRSCEGRGTVVTIIIPH 769
Cdd:cd16943 76 SYRIIQKHGGTIRVASVPGGGTRFTIILPI 105
|
|
| phoR |
PRK11006 |
phosphate regulon sensor histidine kinase PhoR; |
545-768 |
1.18e-22 |
|
phosphate regulon sensor histidine kinase PhoR;
Pssm-ID: 182895 [Multi-domain] Cd Length: 430 Bit Score: 101.63 E-value: 1.18e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 545 AKSEFLANMSHELRTPLNAILGFSEILLNEmfgPVGSPKYSEYARDIHDSGKHLLNVINDILDMSKIEAGHMRINRETID 624
Cdd:PRK11006 203 ARRNFFANVSHELRTPLTVLQGYLEMMQDQ---PLEGALREKALHTMREQTQRMEGLVKQLLTLSKIEAAPTIDLNEKVD 279
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 625 LaPLIEETLRLTAIQAEQKNITVQQKVCAGLTMQGDRRAMKQIMLNLLSNAVKFTGDGGSIALRTHVHEAAMILTIADTG 704
Cdd:PRK11006 280 V-PMMLRVLEREAQTLSQGKHTITFEVDNSLKVFGNEDQLRSAISNLVYNAVNHTPEGTHITVRWQRVPQGAEFSVEDNG 358
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 549125420 705 IGIPTQALEKIGQPFEQVQSQYAKSQGGSGLGLAISRSLVKLHGGTMKIRSCEGRGTVVTIIIP 768
Cdd:PRK11006 359 PGIAPEHIPRLTERFYRVDKARSRQTGGSGLGLAIVKHALSHHDSRLEIESEVGKGTRFSFVLP 422
|
|
| PRK09303 |
PRK09303 |
histidine kinase; |
525-749 |
1.57e-22 |
|
histidine kinase;
Pssm-ID: 236462 [Multi-domain] Cd Length: 380 Bit Score: 100.41 E-value: 1.57e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 525 LSDANANYLAEKERAQAANRAKSEFLANMSHELRTPLNAILGFSEILLNEMFGPVGSPKYSEYARdIHDSGKHLLNVIN- 603
Cdd:PRK09303 130 LSDELFVLRQENETLLEQLKFKDRVLAMLAHDLRTPLTAASLALETLELGQIDEDTELKPALIEQ-LQDQARRQLEEIEr 208
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 604 ---DILDMSKIEAGHMRINRETIDLAPLIEETLRLTAIQAEQKNITVQQKVCAGL-TMQGDRRAMKQIMLNLLSNAVKFT 679
Cdd:PRK09303 209 litDLLEVGRTRWEALRFNPQKLDLGSLCQEVILELEKRWLAKSLEIQTDIPSDLpSVYADQERIRQVLLNLLDNAIKYT 288
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 549125420 680 GDGGSIAL----RTH--VHeaamiLTIADTGIGIPTQALEKIgqpFE-QVQSQYAKSQGGSGLGLAISRSLVKLHGG 749
Cdd:PRK09303 289 PEGGTITLsmlhRTTqkVQ-----VSICDTGPGIPEEEQERI---FEdRVRLPRDEGTEGYGIGLSVCRRIVRVHYG 357
|
|
| HATPase_TutC-TodS-like |
cd16925 |
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ... |
660-768 |
2.52e-21 |
|
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.
Pssm-ID: 340402 [Multi-domain] Cd Length: 110 Bit Score: 89.47 E-value: 2.52e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 660 DRRAMKQIMLNLLSNAVKFTGDGGSIALRTHVHEAAMIL-TIADTGIGIPTQALEKIGQPFEQVQSQYAKSQGGSGLGLA 738
Cdd:cd16925 1 DAEKYERVVLNLLSNAFKFTPDGGRIRCILEKFRLNRFLlTVSDSGPGIPPNLREEIFERFRQGDGSSTRAHGGTGLGLS 80
|
90 100 110
....*....|....*....|....*....|
gi 549125420 739 ISRSLVKLHGGTMKIRSCEGRGTVVTIIIP 768
Cdd:cd16925 81 IVKEFVELHGGTVTVSDAPGGGALFQVELP 110
|
|
| marine_sort_HK |
TIGR03785 |
proteobacterial dedicated sortase system histidine kinase; This histidine kinase protein is ... |
547-768 |
8.87e-20 |
|
proteobacterial dedicated sortase system histidine kinase; This histidine kinase protein is paired with an adjacent response regulator (TIGR03787) gene. It co-occurs with a variant sortase enzyme (TIGR03784), usually in the same gene neighborhood, in proteobacterial species most of which are marine, and with an LPXTG motif-containing sortase target conserved protein (TIGR03788). Sortases and LPXTG proteins are far more common in Gram-positive bacteria, where sortase systems mediate attachment to the cell wall or cross-linking of pilin structures. We give this predicted sensor histidine kinase the gene symbol psdS, for Proteobacterial Dedicated Sortase system Sensor histidine kinase.
Pssm-ID: 163497 [Multi-domain] Cd Length: 703 Bit Score: 94.42 E-value: 8.87e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 547 SEFLANMS----HELRTPLnAILGFSEILLNEMFGPVGSPKYSEYARdihDSGKHLLNVINDILDMSKIEAGHMRINRET 622
Cdd:TIGR03785 482 THYLENMSsrlsHELRTPV-AVVRSSLENLELQALEQEKQKYLERAR---EGTERLSMILNNMSEATRLEQAIQSAEVED 557
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 623 IDLAPLIEEtlrltAIQAEQKNITVQQ---KVCA-GLTMQGDRRAMKQIMLNLLSNAVKFTGDGGSIALRTHVHEAAMIL 698
Cdd:TIGR03785 558 FDLSEVLSG-----CMQGYQMTYPPQRfelNIPEtPLVMRGSPELIAQMLDKLVDNAREFSPEDGLIEVGLSQNKSHALL 632
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 549125420 699 TIADTGIGIPTQALEKIGQPFEQVQSQYAKSQGGSGLGLAISRSLVKLHGGTMKIRS-CEGRGTVVTIIIP 768
Cdd:TIGR03785 633 TVSNEGPPLPEDMGEQLFDSMVSVRDQGAQDQPHLGLGLYIVRLIADFHQGRIQAENrQQNDGVVFRISLP 703
|
|
| HATPase_BaeS-like |
cd16946 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
660-768 |
9.56e-20 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.
Pssm-ID: 340422 [Multi-domain] Cd Length: 109 Bit Score: 85.21 E-value: 9.56e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 660 DRRAMKQIMLNLLSNAVKFTGDGGSIALRTHVHEAAMILTIADTGIGIPTQALEKIGQPFEQVQSQYAKSQGGSGLGLAI 739
Cdd:cd16946 1 DRDRLQQLFVNLLENSLRYTDTGGKLRIRAAQTPQEVRLDVEDSAPGVSDDQLARLFERFYRVESSRNRASGGSGLGLAI 80
|
90 100
....*....|....*....|....*....
gi 549125420 740 SRSLVKLHGGTMKIRSCEGRGTVVTIIIP 768
Cdd:cd16946 81 CHNIALAHGGTISAEHSPLGGLRLVLTLP 109
|
|
| PRK10549 |
PRK10549 |
two-component system sensor histidine kinase BaeS; |
531-751 |
1.07e-19 |
|
two-component system sensor histidine kinase BaeS;
Pssm-ID: 182539 [Multi-domain] Cd Length: 466 Bit Score: 92.77 E-value: 1.07e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 531 NYLAEK-ERAQAANRAkseFLANMSHELRTPLNAILGFSEIL-----------LNEMFGPVGSpkyseyardihdsgkhL 598
Cdd:PRK10549 227 NQLASTlEKNEQMRRD---FMADISHELRTPLAVLRGELEAIqdgvrkftpesVASLQAEVGT----------------L 287
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 599 LNVINDILDMSKIEAGHMRINRETIDLAPLIEETLRLTAIQAEQKNITVQQKVCAGLTMQGDRRAMKQIMLNLLSNAVKF 678
Cdd:PRK10549 288 TKLVDDLHQLSLSDEGALAYRKTPVDLVPLLEVAGGAFRERFASRGLTLQLSLPDSATVFGDPDRLMQLFNNLLENSLRY 367
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 549125420 679 TGDGGSIALRTHVHEAAMILTIADTGIGIPTQALEKIGQPFEQVQSQYAKSQGGSGLGLAISRSLVKLHGGTM 751
Cdd:PRK10549 368 TDSGGSLHISAEQRDKTLRLTFADSAPGVSDEQLQKLFERFYRTEGSRNRASGGSGLGLAICLNIVEAHNGRI 440
|
|
| CitA |
COG3290 |
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ... |
390-768 |
1.76e-19 |
|
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];
Pssm-ID: 442519 [Multi-domain] Cd Length: 389 Bit Score: 91.45 E-value: 1.76e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 390 IESTSEAFVLWDKNDRLVMCNTHYQKAYGLPdsvlvagtekstvyaaaarpVVERRVADPDQSGLS--RTTEVQLADDRW 467
Cdd:COG3290 90 LESIREGVIAVDRDGRITLINDAARRLLGLD--------------------AIGRPIDEVLAEVLEtgERDEEILLNGRV 149
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 468 LQINERRTRDGGLVsVGTDITLlkrhqerlrdserrlmatigdlsasqhkleRQKTELsDANANYLAEKERAQAANRAks 547
Cdd:COG3290 150 LVVNRVPIRDDGRV-VGAVATF------------------------------RDRTEL-ERLEEELEGVKELAEALRA-- 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 548 eflanMSHELRTPLNAILGFSEILlnemfgpvgspKYSEyardihdsgkhLLNVINDILDMSKIEAGHMRINRETIDLAP 627
Cdd:COG3290 196 -----QRHDFRNHLHTISGLLQLG-----------EYDE-----------ALEYIDEISEELQELIDSLLSRIGNPVLAA 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 628 LIEETLRltaiQAEQKNITVQQKVCAGLTMQG-DRRAMKQIMLNLLSNAV----KFTGDGGSIALRTHVHEAAMILTIAD 702
Cdd:COG3290 249 LLLGKAA----RARERGIDLTIDIDSDLPDLPlSDTDLVTILGNLLDNAIeaveKLPEEERRVELSIRDDGDELVIEVED 324
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 549125420 703 TGIGIPTQALEKIgqpFEQ-VQSqyaKSQGGSGLGLAISRSLVKLHGGTMKIRSCEGRGTVVTIIIP 768
Cdd:COG3290 325 SGPGIPEELLEKI---FERgFST---KLGEGRGLGLALVKQIVEKYGGTIEVESEEGEGTVFTVRLP 385
|
|
| HisKA |
pfam00512 |
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ... |
545-614 |
5.16e-19 |
|
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.
Pssm-ID: 459839 [Multi-domain] Cd Length: 66 Bit Score: 81.49 E-value: 5.16e-19
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 545 AKSEFLANMSHELRTPLNAILGFSEILLNEmfgpVGSPKYSEYARDIHDSGKHLLNVINDILDMSKIEAG 614
Cdd:pfam00512 1 AKSEFLANLSHELRTPLTAIRGYLELLRDE----KLDEEQREYLETILRSAERLLRLINDLLDLSRIEAG 66
|
|
| HisKA |
smart00388 |
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ... |
545-614 |
2.51e-18 |
|
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.
Pssm-ID: 214644 [Multi-domain] Cd Length: 66 Bit Score: 79.53 E-value: 2.51e-18
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 545 AKSEFLANMSHELRTPLNAILGFSEILLNEmfgpVGSPKYSEYARDIHDSGKHLLNVINDILDMSKIEAG 614
Cdd:smart00388 1 AKREFLANLSHELRTPLTAIRGYLELLLDT----ELSEEQREYLETILREAERLLRLINDLLDLSRIEAG 66
|
|
| PRK09835 |
PRK09835 |
Cu(+)/Ag(+) sensor histidine kinase; |
546-771 |
6.88e-18 |
|
Cu(+)/Ag(+) sensor histidine kinase;
Pssm-ID: 182101 [Multi-domain] Cd Length: 482 Bit Score: 87.52 E-value: 6.88e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 546 KSEFLANMSHELRTPLNAILGFSEILLNEmfgpVGSPK------YS---EYARdihdsgkhLLNVINDILDMSKIEAGHM 616
Cdd:PRK09835 262 QSNFSADIAHEIRTPITNLITQTEIALSQ----SRSQKeledvlYSnleELTR--------MAKMVSDMLFLAQADNNQL 329
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 617 RINRETIDLAPLIEETLRLTAIQAEQKNITVQ--QKVCAgltMQGDRRAMKQIMLNLLSNAVKFTGDGGSIALRTHVHEA 694
Cdd:PRK09835 330 IPEKKMLDLADEVGKVFDFFEAWAEERGVELRfvGDPCQ---VAGDPLMLRRAISNLLSNALRYTPAGEAITVRCQEVDH 406
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 549125420 695 AMILTIADTGIGIPTQALEKIGQPFEQVQSQYAKSQGGSGLGLAISRSLVKLHGGTMKIRScEGRGTVVTIIIPHAA 771
Cdd:PRK09835 407 QVQLVVENPGTPIAPEHLPRLFDRFYRVDPSRQRKGEGSGIGLAIVKSIVVAHKGTVAVTS-DARGTRFVISLPRLE 482
|
|
| PRK13837 |
PRK13837 |
two-component system VirA-like sensor kinase; |
554-773 |
8.98e-18 |
|
two-component system VirA-like sensor kinase;
Pssm-ID: 237526 [Multi-domain] Cd Length: 828 Bit Score: 88.20 E-value: 8.98e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 554 SHELRTPLNAILGFSEILLNEMfgPVGSPKySEYARDIHDSGKHLLNVINDILDMSKIEAGhmriNRETIDLAPLIEETL 633
Cdd:PRK13837 458 AHNFNNILGAILGYAEMALNKL--ARHSRA-ARYIDEIISAGARARLIIDQILAFGRKGER----NTKPFDLSELVTEIA 530
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 634 R-LTAIQAEQKNITVQQKVcAGLTMQGDRRAMKQIMLNLLSNAVKFTGDGGSIALRTHVHEAA---------------MI 697
Cdd:PRK13837 531 PlLRVSLPPGVELDFDQDQ-EPAVVEGNPAELQQVLMNLCSNAAQAMDGAGRVDISLSRAKLRapkvlshgvlppgryVL 609
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 549125420 698 LTIADTGIGIPTQALEKIGQPFEQVQSqyaksqGGSGLGLAISRSLVKLHGGTMKIRSCEGRGTVVTIIIPHAAGV 773
Cdd:PRK13837 610 LRVSDTGAGIDEAVLPHIFEPFFTTRA------GGTGLGLATVHGIVSAHAGYIDVQSTVGRGTRFDVYLPPSSKV 679
|
|
| cpxA |
PRK09470 |
envelope stress sensor histidine kinase CpxA; |
550-768 |
1.55e-17 |
|
envelope stress sensor histidine kinase CpxA;
Pssm-ID: 236532 [Multi-domain] Cd Length: 461 Bit Score: 86.14 E-value: 1.55e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 550 LANMSHELRTPLnAILGFSEILLNEMFGpvgspKYSEYARdIHDSGKHLLNVINDILDMSKIEAgHMRINRETIDLAPLI 629
Cdd:PRK09470 247 LSDISHELRTPL-TRLQLATALLRRRQG-----ESKELER-IETEAQRLDSMINDLLVLSRNQQ-KNHLERETFKANSLW 318
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 630 EETLRLTAIQAEQKNITVQ-QKVCAGLTMQGDRRAMKQIMLNLLSNAVKFTGDggSIALRTHVHEAAMILTIADTGIGIP 708
Cdd:PRK09470 319 SEVLEDAKFEAEQMGKSLTvSAPPGPWPINGNPNALASALENIVRNALRYSHT--KIEVAFSVDKDGLTITVDDDGPGVP 396
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 549125420 709 TQALEKIGQPFEQVQSQYAKSQGGSGLGLAISRSLVKLHGGTMKI-RSCEGrGTVVTIIIP 768
Cdd:PRK09470 397 EEEREQIFRPFYRVDEARDRESGGTGLGLAIVENAIQQHRGWVKAeDSPLG-GLRLTIWLP 456
|
|
| HATPase_EcPhoR-like |
cd16952 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
670-770 |
1.72e-17 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.
Pssm-ID: 340428 [Multi-domain] Cd Length: 108 Bit Score: 78.78 E-value: 1.72e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 670 NLLSNAVKFTGDGGSIALRTHVHEAAMILTIADTGIGIPTQALEKIGQPFEQVQSQYAKSQGGSGLGLAISRSLVKLHGG 749
Cdd:cd16952 7 NLVSNAVKYTPPSDTITVRWSQEESGARLSVEDTGPGIPPEHIPRLTERFYRVDIERCRNTGGTGLGLAIVKHVMSRHDA 86
|
90 100
....*....|....*....|.
gi 549125420 750 TMKIRSCEGRGTVVTIIIPHA 770
Cdd:cd16952 87 RLLIASELGKGSRFTCLFPSS 107
|
|
| HisKA |
cd00082 |
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ... |
543-610 |
2.81e-17 |
|
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.
Pssm-ID: 119399 [Multi-domain] Cd Length: 65 Bit Score: 76.48 E-value: 2.81e-17
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 549125420 543 NRAKSEFLANMSHELRTPLNAILGFSEILLNEMFGPvgsPKYSEYARDIHDSGKHLLNVINDILDMSK 610
Cdd:cd00082 1 LQAKGEFLANVSHELRTPLTAIRGALELLEEELLDD---EEQREYLERIREEAERLLRLINDLLDLSR 65
|
|
| HATPase_BasS-like |
cd16940 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
656-765 |
2.88e-17 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.
Pssm-ID: 340417 [Multi-domain] Cd Length: 113 Bit Score: 78.22 E-value: 2.88e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 656 TMQGDRRAMKQIMLNLLSNAVKFTGDGGSIALRTHVHEAAMILtIADTGIGIPTQALEKIGQPFEQVQSQyakSQGGSGL 735
Cdd:cd16940 6 QVQGDALLLFLLLRNLVDNAVRYSPQGSRVEIKLSADDGAVIR-VEDNGPGIDEEELEALFERFYRSDGQ---NYGGSGL 81
|
90 100 110
....*....|....*....|....*....|
gi 549125420 736 GLAISRSLVKLHGGTMKIRSCEGRGTVVTI 765
Cdd:cd16940 82 GLSIVKRIVELHGGQIFLGNAQGGGLEAWV 111
|
|
| envZ |
PRK09467 |
osmolarity sensor protein; Provisional |
550-771 |
3.85e-17 |
|
osmolarity sensor protein; Provisional
Pssm-ID: 236531 [Multi-domain] Cd Length: 435 Bit Score: 84.58 E-value: 3.85e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 550 LANMSHELRTPLNAILgfseiLLNEMFGPvgspkYSEYARDihdsgkhllNVINDILDMSKIEAGHM-------RINRET 622
Cdd:PRK09467 233 MAGVSHDLRTPLTRIR-----LATEMMSE-----EDGYLAE---------SINKDIEECNAIIEQFIdylrtgqEMPMEM 293
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 623 IDLAPLIEETlrltaIQAE---QKNITVQQKVCAgLTMQGDRRAMKQIMLNLLSNAVKFTGdgGSIALRTHVHEAAMILT 699
Cdd:PRK09467 294 ADLNALLGEV-----IAAEsgyEREIETALQPGP-IEVPMNPIAIKRALANLVVNAARYGN--GWIKVSSGTEGKRAWFQ 365
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 549125420 700 IADTGIGIPTQALEKIGQPFeqVQSQYAKSQGGSGLGLAISRSLVKLHGGTMKIRSCEGRGTVVTIIIPHAA 771
Cdd:PRK09467 366 VEDDGPGIPPEQLKHLFQPF--TRGDSARGSSGTGLGLAIVKRIVDQHNGKVELGNSEEGGLSARAWLPLTT 435
|
|
| PAS |
COG2202 |
PAS domain [Signal transduction mechanisms]; |
254-497 |
1.56e-16 |
|
PAS domain [Signal transduction mechanisms];
Pssm-ID: 441804 [Multi-domain] Cd Length: 258 Bit Score: 80.07 E-value: 1.56e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 254 AESNLRVETALSRGRCGLWDFDLSTRRMFWSGSLYEILGMPPKAtpLSFSDAARMMHSEDGNLYELARAVGCGNLRQIDQ 333
Cdd:COG2202 7 EESERRLRALVESSPDAIIITDLDGRILYVNPAFERLTGYSAEE--LLGKTLRDLLPPEDDDEFLELLRAALAGGGVWRG 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 334 IFRMRHTKGHYVWLRARAQVIRTNNG--PRVIGIAMDVTEQHRLAQRYAEADQRLADAIESTSEAFVLWDKNDRLVMCNT 411
Cdd:COG2202 85 ELRNRRKDGSLFWVELSISPVRDEDGeiTGFVGIARDITERKRAEEALRESEERLRLLVENAPDGIFVLDLDGRILYVNP 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 412 HYQKAYGLPDSVLVaGTEKSTVYAAAARPVVERRVADPDQSGL-SRTTEVQLADD----RWLQINERRTRDG----GLVS 482
Cdd:COG2202 165 AAEELLGYSPEELL-GKSLLDLLHPEDRERLLELLRRLLEGGReSYELELRLKDGdgrwVWVEASAVPLRDGgeviGVLG 243
|
250
....*....|....*
gi 549125420 483 VGTDITLLKRHQERL 497
Cdd:COG2202 244 IVRDITERKRAEEAL 258
|
|
| HATPase_FilI-like |
cd16921 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
664-768 |
4.09e-16 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340398 [Multi-domain] Cd Length: 105 Bit Score: 74.67 E-value: 4.09e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 664 MKQIMLNLLSNAVKFTGDGGSIALRTHVHEAAMILTIA--DTGIGIPTQALEKIGQPFEQVQSQYAksQGGSGLGLAISR 741
Cdd:cd16921 1 LGQVLTNLLGNAIKFRRPRRPPRIEVGAEDVGEEWTFYvrDNGIGIDPEYAEKVFGIFQRLHSREE--YEGTGVGLAIVR 78
|
90 100
....*....|....*....|....*..
gi 549125420 742 SLVKLHGGTMKIRSCEGRGTVVTIIIP 768
Cdd:cd16921 79 KIIERHGGRIWLESEPGEGTTFYFTLP 105
|
|
| PRK10755 |
PRK10755 |
two-component system sensor histidine kinase PmrB; |
549-774 |
2.28e-15 |
|
two-component system sensor histidine kinase PmrB;
Pssm-ID: 236751 [Multi-domain] Cd Length: 356 Bit Score: 78.47 E-value: 2.28e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 549 FLANMSHELRTPLNAILGFSEILlnEMFGPVGSPkySEYAR-DihdsgkHLLNVINDILDMSKIE----AGH---MRINR 620
Cdd:PRK10755 140 FTADVAHELRTPLAGIRLHLELL--EKQHHIDVA--PLIARlD------QMMHTVEQLLQLARAGqsfsSGHyqtVKLLE 209
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 621 ETIDlaPLIEETLRLtaiqAEQKNITVQ-QKVCAGLTMQGDRRAMKQIMLNLLSNAVKFTGDGGSIALRTHVHEAAMILT 699
Cdd:PRK10755 210 DVIL--PSQDELSEM----LEQRQQTLLlPESAADITVQGDATLLRLLLRNLVENAHRYSPEGSTITIKLSQEDGGAVLA 283
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 549125420 700 IADTGIGIPTQALEKIGQPFEQVQSQYaksqGGSGLGLAISRSLVKLHGG--TMKIRScEGRGTVVTIIIPHAAGVC 774
Cdd:PRK10755 284 VEDEGPGIDESKCGELSKAFVRMDSRY----GGIGLGLSIVSRITQLHHGqfFLQNRQ-ERSGTRAWVWLPKAQNVA 355
|
|
| MtrAB_MtrB |
NF040691 |
MtrAB system histidine kinase MtrB; |
544-772 |
3.55e-15 |
|
MtrAB system histidine kinase MtrB;
Pssm-ID: 468655 [Multi-domain] Cd Length: 507 Bit Score: 78.91 E-value: 3.55e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 544 RAKSEFLANMSHELRTPLNAILGFSEILLNEM--FGPvGSPKYSEYARDIHDSGKHLLnviNDILDMSKIEAGHMRINRE 621
Cdd:NF040691 269 RLQQRFVSDVSHELRTPLTTIRMAADVIHDSRddFDP-ATARSAELLHTELDRFESLL---SDLLEISRFDAGAAELDVE 344
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 622 TIDLAPLIEETLRLTAIQAEQKNITVQQKVCAG-LTMQGDRRAMKQIMLNLLSNAVKFtGDGGSIALRTHVHEAAMILTI 700
Cdd:NF040691 345 PVDLRPLVRRVVDALRQLAERAGVELRVDAPGTpVVAEVDPRRVERVLRNLVVNAIEH-GEGKPVVVTVAQDDTAVAVTV 423
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 549125420 701 ADTGIGIPTQALEKIGQPFEQVQSQYAKSQGGSGLGLAISRSLVKLHGGTMKIRSCEGRGTVVTIIIPHAAG 772
Cdd:NF040691 424 RDHGVGLKPGEVALVFDRFWRADPARARTTGGTGLGLAIALEDARLHGGWLEAWGRPGQGSQFRLTLPRVAG 495
|
|
| HATPase_CreC-like |
cd16945 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
664-758 |
4.03e-15 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.
Pssm-ID: 340421 [Multi-domain] Cd Length: 106 Bit Score: 71.72 E-value: 4.03e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 664 MKQIMLNLLSNAVKFTGDGGSIALRTHVHEAAMILTIADTGIGIPTQALEKIgqpFEQVQS--QYAKSQGGSGLGLAISR 741
Cdd:cd16945 5 LRQAINNLLDNAIDFSPEGGLIALQLEADTEGIELLVFDEGSGIPDYALNRV---FERFYSlpRPHSGQKSTGLGLAFVQ 81
|
90
....*....|....*..
gi 549125420 742 SLVKLHGGTMKIRSCEG 758
Cdd:cd16945 82 EVAQLHGGRITLRNRPD 98
|
|
| HATPase_CpxA-like |
cd16949 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
662-768 |
9.39e-15 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.
Pssm-ID: 340425 [Multi-domain] Cd Length: 104 Bit Score: 70.82 E-value: 9.39e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 662 RAMKqimlNLLSNAVKFTGdgGSIALRTHVHEAAMILTIADTGIGIPTQALEKIGQPFEQVQSQYAKSQGGSGLGLAISR 741
Cdd:cd16949 3 RALE----NVLRNALRYSP--SKILLDISQDGDQWTITITDDGPGVPEDQLEQIFLPFYRVDSARDRESGGTGLGLAIAE 76
|
90 100
....*....|....*....|....*..
gi 549125420 742 SLVKLHGGTMKIRSCEGRGTVVTIIIP 768
Cdd:cd16949 77 RAIEQHGGKIKASNRKPGGLRVRIWLP 103
|
|
| PAS_7 |
pfam12860 |
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined ... |
390-495 |
5.60e-14 |
|
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs. The PAS fold appears in archaea, eubacteria and eukarya.
Pssm-ID: 432837 [Multi-domain] Cd Length: 115 Bit Score: 68.72 E-value: 5.60e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 390 IESTSEAFVLWDKNDRLVMCNTHYQKAYGLPDSVLVAGT----------EKSTVYAAAARPVVERRVADPdQSGLSRTTE 459
Cdd:pfam12860 1 LENMSQGLSVFDADLRLVAWNRRYRELLDLPEDLVQVGVpfeeiirynaERGEYGPGDVEAHVRRRLAAA-RAGSPHYFE 79
|
90 100 110
....*....|....*....|....*....|....*.
gi 549125420 460 VQLADDRWLQINERRTRDGGLVSVGTDITLLKRHQE 495
Cdd:pfam12860 80 RERPDGRVIEIRGNPLPDGGFVTTFTDITERRRAEE 115
|
|
| PRK10604 |
PRK10604 |
sensor protein RstB; Provisional |
552-757 |
1.65e-13 |
|
sensor protein RstB; Provisional
Pssm-ID: 236724 [Multi-domain] Cd Length: 433 Bit Score: 73.48 E-value: 1.65e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 552 NMSHELRTPLnailgfseILLN---EMFGPVGSPKYSEYARDIhdsgKHLLNVINDILDMSKIEAGHMRINRETIDLAPL 628
Cdd:PRK10604 218 GIAHELRTPL--------VRLRyrlEMSDNLSAAESQALNRDI----GQLEALIEELLTYARLDRPQNELHLSEPDLPAW 285
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 629 IEEtlRLTAIQAEQKNITVQQKVCA-GLTMQGDRRAMKQIMLNLLSNAVKFTGdgGSIALRTHVHEAAMILTIADTGIGI 707
Cdd:PRK10604 286 LST--HLADIQAVTPEKTVRLDTPHqGDYGALDMRLMERVLDNLLNNALRYAH--SRVRVSLLLDGNQACLIVEDDGPGI 361
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 549125420 708 PTQALEKIGQPFEQVQSQYAKSQGGSGLGLAISRSLVKLHGGTMKIRSCE 757
Cdd:PRK10604 362 PPEERERVFEPFVRLDPSRDRATGGCGLGLAIVHSIALAMGGSVNCDESE 411
|
|
| HATPase_EnvZ-like |
cd16950 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
664-768 |
1.82e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.
Pssm-ID: 340426 [Multi-domain] Cd Length: 101 Bit Score: 67.09 E-value: 1.82e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 664 MKQIMLNLLSNAVKFTGdgGSIALRTHVHEAAMILTIADTGIGIPTQALEKIGQPFEQVQSqyAKSQGGSGLGLAISRSL 743
Cdd:cd16950 1 LKRVLSNLVDNALRYGG--GWVEVSSDGEGNRTRIQVLDNGPGIAPEEVDELFQPFYRGDN--ARGTSGTGLGLAIVQRI 76
|
90 100
....*....|....*....|....*
gi 549125420 744 VKLHGGTMKIRSCEGRGTVVTIIIP 768
Cdd:cd16950 77 SDAHGGSLTLANRAGGGLCARIELP 101
|
|
| HATPase_Glnl-NtrB-like |
cd16918 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
664-768 |
2.53e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).
Pssm-ID: 340395 [Multi-domain] Cd Length: 109 Bit Score: 66.66 E-value: 2.53e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 664 MKQIMLNLLSNAVK-FTGDGGSIALRTHV----------HEAAMILTIADTGIGIPTQALEKIGQPFeqVQSQyaksQGG 732
Cdd:cd16918 1 LIQVFLNLVRNAAQaLAGSGGEIILRTRTqrqvtlghprHRLALRVSVIDNGPGIPPDLQDTIFYPM--VSGR----ENG 74
|
90 100 110
....*....|....*....|....*....|....*.
gi 549125420 733 SGLGLAISRSLVKLHGGTMKIRSCEGRgTVVTIIIP 768
Cdd:cd16918 75 TGLGLAIAQNIVSQHGGVIECDSQPGH-TVFSVSLP 109
|
|
| PRK10337 |
PRK10337 |
sensor protein QseC; Provisional |
549-765 |
1.03e-12 |
|
sensor protein QseC; Provisional
Pssm-ID: 182388 [Multi-domain] Cd Length: 449 Bit Score: 70.83 E-value: 1.03e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 549 FLANMSHELRTPLNAILGFSEIllnemfgpvgspkySEYARDIHDSGKHLL-----------NVINDILDMSKIEAGHMR 617
Cdd:PRK10337 240 FTSDAAHELRSPLAALKVQTEV--------------AQLSDDDPQARKKALlqlhagidratRLVDQLLTLSRLDSLDNL 305
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 618 INRETIDLAPLIEETLRLTAIQAEQKNITVQQKVCA-GLTMQGDRRAMKQIMLNLLSNAVKFTGDGGSIALRTHVHEaam 696
Cdd:PRK10337 306 QDVAEIPLEDLLQSAVMDIYHTAQQAGIDVRLTLNAhPVIRTGQPLLLSLLVRNLLDNAIRYSPQGSVVDVTLNARN--- 382
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 549125420 697 iLTIADTGIGIPTQALEKIGQPFEQVQSQyakSQGGSGLGLAISRSLVKLHGGTMKIRSCEGRGTVVTI 765
Cdd:PRK10337 383 -FTVRDNGPGVTPEALARIGERFYRPPGQ---EATGSGLGLSIVRRIAKLHGMNVSFGNAPEGGFEAKV 447
|
|
| HATPase_VanS-like |
cd16923 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
664-768 |
1.06e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.
Pssm-ID: 340400 [Multi-domain] Cd Length: 102 Bit Score: 64.72 E-value: 1.06e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 664 MKQIMLNLLSNAVKFTGDGGSIALRTHVHEAAMILTIADTGIGIPTQALEKIgqpFEQ-VQSQYAKSQGGSGLGLAISRS 742
Cdd:cd16923 1 LQRVFSNLLSNAIKYSPENTRIYITSFLTDDVVNIMFKNPSSHPLDFKLEKL---FERfYRGDNSRNTEGAGLGLSIAKA 77
|
90 100
....*....|....*....|....*.
gi 549125420 743 LVKLHGGTMKIRScEGRGTVVTIIIP 768
Cdd:cd16923 78 IIELHGGSASAEY-DDNHDLFKVRLP 102
|
|
| HATPase_TmoS-FixL-DctS-like |
cd16920 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
664-768 |
2.00e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340397 [Multi-domain] Cd Length: 104 Bit Score: 63.95 E-value: 2.00e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 664 MKQIMLNLLSNAVKFTGDGGS----IALRTHVHE-AAMILTIADTGIGIPTQALEKIGQPFEQVQSQyaksqgGSGLGLA 738
Cdd:cd16920 1 IQQVLINLVRNGIEAMSEGGCerreLTIRTSPADdRAVTISVKDTGPGIAEEVAGQLFDPFYTTKSE------GLGMGLS 74
|
90 100 110
....*....|....*....|....*....|
gi 549125420 739 ISRSLVKLHGGTMKIRSCEGRGTVVTIIIP 768
Cdd:cd16920 75 ICRSIIEAHGGRLSVESPAGGGATFQFTLP 104
|
|
| HATPase_YcbM-like |
cd16947 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
658-765 |
2.62e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).
Pssm-ID: 340423 [Multi-domain] Cd Length: 125 Bit Score: 64.46 E-value: 2.62e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 658 QGDRRAMKQIMLNLLSNAVKFTGDGGSIALRTHVHEAAMILTIADTGIGIPTQALEKIGQPFEQVQSQYAKSQGGSGLGL 737
Cdd:cd16947 15 NANTEALQRILKNLISNAIKYGSDGKFLGMTLREDEKHVYIDIWDKGKGISETEKDHVFERLYTLEDSRNSAKQGNGLGL 94
|
90 100
....*....|....*....|....*...
gi 549125420 738 AISRSLVKLHGGTMKIRSCEGRGTVVTI 765
Cdd:cd16947 95 TITKRLAESMGGSIYVNSKPYEKTVFTV 122
|
|
| HATPase_NtrY-like |
cd16944 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
660-768 |
5.17e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.
Pssm-ID: 340420 [Multi-domain] Cd Length: 108 Bit Score: 62.94 E-value: 5.17e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 660 DRRAMKQIMLNLLSNAVK----FTGDGGSIALRTHV-HEAAMILTIADTGIGIPTQALEKIGQPFEQVQSQyaksqgGSG 734
Cdd:cd16944 1 DTTQISQVLTNILKNAAEaiegRPSDVGEVRIRVEAdQDGRIVLIVCDNGKGFPREMRHRATEPYVTTRPK------GTG 74
|
90 100 110
....*....|....*....|....*....|....
gi 549125420 735 LGLAISRSLVKLHGGTMKIRSCEGRGTVVTIIIP 768
Cdd:cd16944 75 LGLAIVKKIMEEHGGRISLSNREAGGACIRIILP 108
|
|
| HATPase_BceS-YxdK-YvcQ-like |
cd16948 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
660-768 |
6.14e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.
Pssm-ID: 340424 [Multi-domain] Cd Length: 109 Bit Score: 62.69 E-value: 6.14e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 660 DRRAMKQIMLNLLSNAVKFTGDGGSIALRTHVHEAAMILTIADTGIGIPTQALEKIGQPFEQVQSQYaKSQGGSGLGLAI 739
Cdd:cd16948 2 DAKWLSFIIGQIVSNALKYSKQGGKIEIYSETNEQGVVLSIKDFGIGIPEEDLPRVFDKGFTGENGR-NFQESTGMGLYL 80
|
90 100
....*....|....*....|....*....
gi 549125420 740 SRSLVKLHGGTMKIRSCEGRGTVVTIIIP 768
Cdd:cd16948 81 VKKLCDKLGHKIDVESEVGEGTTFTITFP 109
|
|
| HATPase_RstB-like |
cd16939 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
664-768 |
7.19e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.
Pssm-ID: 340416 [Multi-domain] Cd Length: 104 Bit Score: 62.45 E-value: 7.19e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 664 MKQIMLNLLSNAVKFTGDGGSIALRthVHEAAMILTIADTGIGIPTQALEKIGQPFEQVQSQYAKSQGGSGLGLAISRSL 743
Cdd:cd16939 1 MARALDNLLRNALRYAHRTVRIALL--VSGGRLTLIVEDDGPGIPAAARERVFEPFVRLDPSRDRATGGFGLGLAIVHRV 78
|
90 100
....*....|....*....|....*
gi 549125420 744 VKLHGGTMKIRSCEGRGTVVTIIIP 768
Cdd:cd16939 79 ALWHGGHVECDDSELGGACFRLTWP 103
|
|
| HATPase_CckA-like |
cd16919 |
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ... |
664-768 |
8.46e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).
Pssm-ID: 340396 [Multi-domain] Cd Length: 116 Bit Score: 62.78 E-value: 8.46e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 664 MKQIMLNLLSNAVKFTGDGGSIALRT-----------HVHEAA----MILTIADTGIGIPTQALEKIGQPFEQvqsqyAK 728
Cdd:cd16919 1 LELAILNLAVNARDAMPEGGRLTIETsnqrvdadyalNYRDLIpgnyVCLEVSDTGSGMPAEVLRRAFEPFFT-----TK 75
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 549125420 729 SQG-GSGLGLAISRSLVKLHGGTMKIRSCEGRGTVVTIIIP 768
Cdd:cd16919 76 EVGkGTGLGLSMVYGFVKQSGGHLRIYSEPGVGTTVRIYLP 116
|
|
| HATPase_SpaK_NisK-like |
cd16975 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
660-767 |
1.04e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.
Pssm-ID: 340434 [Multi-domain] Cd Length: 107 Bit Score: 62.09 E-value: 1.04e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 660 DRRAMKQIMLNLLSNAVKFTGDGGSIALRTHVHEAAMILTIADTGIGIPTQALEKIGQPFEQvQSQYAKSQGGSGLGLAI 739
Cdd:cd16975 1 DTLLLSRALINIISNACQYAPEGGTVSISIYDEEEYLYFEIWDNGHGFSEQDLKKALELFYR-DDTSRRSGGHYGMGLYI 79
|
90 100
....*....|....*....|....*...
gi 549125420 740 SRSLVKLHGGTMKIRSCEGRGTVVTIII 767
Cdd:cd16975 80 AKNLVEKHGGSLIIENSQKGGAEVTVKI 107
|
|
| PAS_3 |
pfam08447 |
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined ... |
280-366 |
3.82e-11 |
|
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs. The PAS fold appears in archaea, eubacteria and eukarya.
Pssm-ID: 430001 [Multi-domain] Cd Length: 89 Bit Score: 60.05 E-value: 3.82e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 280 RMFWSGSLYEILGMPPKATPLSFSDAARMMHSEDGNLY--ELARAVGCGnlRQIDQIFRMRHTKGHYVWLRARAQVIRTN 357
Cdd:pfam08447 1 IIYWSPRFEEILGYTPEELLGKGESWLDLVHPDDRERVreALWEALKGG--EPYSGEYRIRRKDGEYRWVEARARPIRDE 78
|
90
....*....|.
gi 549125420 358 NG--PRVIGIA 366
Cdd:pfam08447 79 NGkpVRVIGVA 89
|
|
| HATPase_DpiB-CitA-like |
cd16915 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
667-768 |
6.62e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.
Pssm-ID: 340392 [Multi-domain] Cd Length: 104 Bit Score: 59.61 E-value: 6.62e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 667 IMLNLLSNAVKFTGDGG------SIALRTHVHEAamILTIADTGIGIPTQALEKIgqpFEQVQSqyAKSQGGSGLGLAIS 740
Cdd:cd16915 4 IVGNLIDNALDALAATGapnkqvEVFLRDEGDDL--VIEVRDTGPGIAPELRDKV---FERGVS--TKGQGERGIGLALV 76
|
90 100
....*....|....*....|....*...
gi 549125420 741 RSLVKLHGGTMKIRSCEGRGTVVTIIIP 768
Cdd:cd16915 77 RQSVERLGGSITVESEPGGGTTFSIRIP 104
|
|
| HATPase_HupT_MifS-like |
cd16976 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
664-767 |
9.08e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.
Pssm-ID: 340435 [Multi-domain] Cd Length: 102 Bit Score: 59.39 E-value: 9.08e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 664 MKQIMLNLLSNAVKFTGD--GGSIALRTHVHEAAMILTIADTGIGIPTQALEKIGQPFEQVqsqyaKSQG-GSGLGLAIS 740
Cdd:cd16976 1 IQQVLMNLLQNALDAMGKveNPRIRIAARRLGGRLVLVVRDNGPGIAEEHLSRVFDPFFTT-----KPVGkGTGLGLSIS 75
|
90 100
....*....|....*....|....*..
gi 549125420 741 RSLVKLHGGTMKIRSCEGRGTVVTIII 767
Cdd:cd16976 76 YGIVEEHGGRLSVANEEGAGARFTFDL 102
|
|
| glnL |
PRK11073 |
nitrogen regulation protein NR(II); |
533-768 |
2.44e-10 |
|
nitrogen regulation protein NR(II);
Pssm-ID: 182947 [Multi-domain] Cd Length: 348 Bit Score: 62.79 E-value: 2.44e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 533 LAEKERAQAANRAKSEFLANMSHELRTPLNAILGFSEiLLNEMFgPvgSPKYSEYARDIHDSGKHLLNVINDILdmskie 612
Cdd:PRK11073 117 LSQEQLQHAQQVAARDLVRGLAHEIKNPLGGLRGAAQ-LLSKAL-P--DPALTEYTKVIIEQADRLRNLVDRLL------ 186
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 613 aGHMRINRETID-LAPLIEETLRLTAIQAEQkNITVQQKVCAGL---TMQGDRraMKQIMLNLLSNAVKFTGD-GGSIAL 687
Cdd:PRK11073 187 -GPQRPGTHVTEsIHKVAERVVQLVSLELPD-NVRLIRDYDPSLpelAHDPDQ--IEQVLLNIVRNALQALGPeGGTITL 262
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 688 RTH-VHE----------AAMIlTIADTGIGIPTQALEKIGQPFeqvqsqYAKSQGGSGLGLAISRSLVKLHGGTMKIRSC 756
Cdd:PRK11073 263 RTRtAFQltlhgeryrlAARI-DIEDNGPGIPPHLQDTLFYPM------VSGREGGTGLGLSIARNLIDQHSGKIEFTSW 335
|
250
....*....|..
gi 549125420 757 EGRgTVVTIIIP 768
Cdd:PRK11073 336 PGH-TEFSVYLP 346
|
|
| HATPase_BvrS-ChvG-like |
cd16953 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
666-751 |
3.98e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.
Pssm-ID: 340429 [Multi-domain] Cd Length: 110 Bit Score: 57.58 E-value: 3.98e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 666 QIMLNLLSNAVKFT-GDGGSIALRTHVHEAAMILTIADTGIGIPTQALEKIgqpFEQVQSQYAKSQG---GSGLGLAISR 741
Cdd:cd16953 3 QVLRNLIGNAISFSpPDTGRITVSAMPTGKMVTISVEDEGPGIPQEKLESI---FDRFYTERPANEAfgqHSGLGLSISR 79
|
90
....*....|
gi 549125420 742 SLVKLHGGTM 751
Cdd:cd16953 80 QIIEAHGGIS 89
|
|
| PRK09776 |
PRK09776 |
putative diguanylate cyclase; Provisional |
259-401 |
6.03e-10 |
|
putative diguanylate cyclase; Provisional
Pssm-ID: 182070 [Multi-domain] Cd Length: 1092 Bit Score: 63.15 E-value: 6.03e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 259 RVETALSRGRCGLWDFDLSTRRMFWSGSLYEILGMPPKATPlSFSDAARMMHSEDGN--LYELARAVgcGNLRQIDQIFR 336
Cdd:PRK09776 411 RITLANEAGGIGIWEWDLKPNIISWDKRMFELYEIPPHIKP-TWQVWYACLHPEDRQrvEKEIRDAL--QGRSPFKLEFR 487
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 549125420 337 MRhTKGHYVWLRARAQVIRTNNGP--RVIGIAMDVTEQHRLAQRYAEADQRLADAIESTSEAFVLWD 401
Cdd:PRK09776 488 IV-VKDGVRHIRALANRVLNKDGEveRLLGINMDMTEVRQLNEALFQEKERLHITLDSIGEAVVCTD 553
|
|
| YesM |
COG2972 |
Sensor histidine kinase YesM [Signal transduction mechanisms]; |
671-768 |
6.31e-10 |
|
Sensor histidine kinase YesM [Signal transduction mechanisms];
Pssm-ID: 442211 [Multi-domain] Cd Length: 445 Bit Score: 62.34 E-value: 6.31e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 671 LLSNAVKF----TGDGGSIALRTHVHEAAMILTIADTGIGIPTQALEKIgqpfeqvQSQYAKSQGGSGLGLAISRSLVKL 746
Cdd:COG2972 344 LVENAIEHgiepKEGGGTIRISIRKEGDRLVITVEDNGVGMPEEKLEKL-------LEELSSKGEGRGIGLRNVRERLKL 416
|
90 100
....*....|....*....|....*
gi 549125420 747 H---GGTMKIRSCEGRGTVVTIIIP 768
Cdd:COG2972 417 YygeEYGLEIESEPGEGTTVTIRIP 441
|
|
| PRK10618 |
PRK10618 |
phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional |
535-768 |
6.74e-10 |
|
phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional
Pssm-ID: 236726 [Multi-domain] Cd Length: 894 Bit Score: 62.64 E-value: 6.74e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 535 EKERAQAANRAkseFLANMSHELRTPLNAI----LGFSEILLNEMfgpvgspkYSEYARDIHDSGKHLLNVINDILDMSK 610
Cdd:PRK10618 442 EYEKNQQARKA---FLQNIGDELKQPLQSLaqlaAQLRQTSDEEQ--------QQPELDQLAEQSDVLVRLVDNIQLLNM 510
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 611 IEAGHMRINRETIDLAPLIEETLR--LTAIQAEQKNITVQQKVCAGLTMQGDRRAMKQIMLNLLSNAVKFTgDGGSIAL- 687
Cdd:PRK10618 511 LETQDWKPEQELFSLQDLIDEVLPevLPAIKRKGLQLLIHNHLKAEQLRIGDRDALRKILLLLLNYAITTT-AYGKITLe 589
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 688 --RTHVHEAAMILTIADTGIGIPTQALEKIGQPF--EQVQSQYAKsqgGSGLGLAISRSLVKLHGGTMKIRSCEGRGTVV 763
Cdd:PRK10618 590 vdQDESSPDRLTIRILDTGAGVSIKELDNLHFPFlnQTQGDRYGK---ASGLTFFLCNQLCRKLGGHLTIKSREGLGTRY 666
|
....*
gi 549125420 764 TIIIP 768
Cdd:PRK10618 667 SIHLK 671
|
|
| PRK13557 |
PRK13557 |
histidine kinase; Provisional |
617-768 |
1.16e-09 |
|
histidine kinase; Provisional
Pssm-ID: 237425 [Multi-domain] Cd Length: 540 Bit Score: 61.61 E-value: 1.16e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 617 RINRETIDLAPLIEETLRLtAIQAEQKNITVQQKVCAGL-TMQGDRRAMKQIMLNLLSNAVKFTGDGGSIALRT-----H 690
Cdd:PRK13557 231 RLEGRVLNLNGLVSGMGEL-AERTLGDAVTIETDLAPDLwNCRIDPTQAEVALLNVLINARDAMPEGGRVTIRTrnveiE 309
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 691 VHEAAMI----------LTIADTGIGIPTQALEKIGQPFEQVqsqyaKSQG-GSGLGLAISRSLVKLHGGTMKIRSCEGR 759
Cdd:PRK13557 310 DEDLAMYhglppgryvsIAVTDTGSGMPPEILARVMDPFFTT-----KEEGkGTGLGLSMVYGFAKQSGGAVRIYSEVGE 384
|
....*....
gi 549125420 760 GTVVTIIIP 768
Cdd:PRK13557 385 GTTVRLYFP 393
|
|
| COG4192 |
COG4192 |
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ... |
508-763 |
9.11e-08 |
|
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];
Pssm-ID: 443346 [Multi-domain] Cd Length: 640 Bit Score: 55.46 E-value: 9.11e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 508 IGDLSASQHKLERQKTELSDANANYLAEKERAQAANRAKSEFL---ANM----------SHELRTPLNAILGFSeillne 574
Cdd:COG4192 382 IGRIARLLRVFRDQAIEKTQELETEIEERKRIEKNLRQTQDELiqaAKMavvgqtmtslAHELNQPLNAMSMYL------ 455
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 575 mfgpvgspkYSEYARDIHDSGKHLLNVINDILD----MSKIEAGHMRINRET------IDLAPLIEETLRLTAIQAEQKN 644
Cdd:COG4192 456 ---------FSAKKALEQENYAQLPTSLDKIEGlierMDKIIKSLRQFSRKSdtplqpVDLRQVIEQAWELVESRAKPQQ 526
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 645 ITVQQKvcAGLTMQGDRRAMKQIMLNLLSNAVKFTGDGGSIALRTHVHEAAMILTIADTGIGIPTqaLEKIGQPFeqvqs 724
Cdd:COG4192 527 ITLHIP--DDLMVQGDQVLLEQVLVNLLVNALDAVATQPQISVDLLSNAENLRVAISDNGNGWPL--VDKLFTPF----- 597
|
250 260 270
....*....|....*....|....*....|....*....
gi 549125420 725 qYAKSQGGSGLGLAISRSLVKLHGGTMKIRSCEGRGTVV 763
Cdd:COG4192 598 -TTTKEVGLGLGLSICRSIMQQFGGDLYLASTLERGAMV 635
|
|
| HATPase_PhoQ-like |
cd16954 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
643-753 |
2.20e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.
Pssm-ID: 340430 [Multi-domain] Cd Length: 135 Bit Score: 50.71 E-value: 2.20e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 643 KNITVQQKVCAGLTMQGDRRAMKQIMLNLLSNAVKFTgdGGSIALRTHVHEAAMILTIADTGIGIPTQALEKIGQPFEQV 722
Cdd:cd16954 17 KGVSISLDISPELRFPGERNDLMELLGNLLDNACKWC--LEFVEVTARQTDGGLHLIVDDDGPGVPESQRSKIFQRGQRL 94
|
90 100 110
....*....|....*....|....*....|.
gi 549125420 723 QSQYAksqgGSGLGLAISRSLVKLHGGTMKI 753
Cdd:cd16954 95 DEQRP----GQGLGLAIAKEIVEQYGGELSL 121
|
|
| ComP |
COG4585 |
Signal transduction histidine kinase ComP [Signal transduction mechanisms]; |
671-771 |
2.28e-07 |
|
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
Pssm-ID: 443642 [Multi-domain] Cd Length: 252 Bit Score: 52.70 E-value: 2.28e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 671 LLSNAVKfTGDGGSIALRTHVHEAAMILTIADTGIGIPTQALekigqpfeqvqsqyaksqGGSGLGLAISRSLVKLHGGT 750
Cdd:COG4585 170 ALTNALK-HAGATRVTVTLEVDDGELTLTVRDDGVGFDPEAA------------------PGGGLGLRGMRERAEALGGT 230
|
90 100
....*....|....*....|.
gi 549125420 751 MKIRSCEGRGTVVTIIIPHAA 771
Cdd:COG4585 231 LTIGSAPGGGTRVRATLPLAA 251
|
|
| PAS |
COG2202 |
PAS domain [Signal transduction mechanisms]; |
374-504 |
2.41e-07 |
|
PAS domain [Signal transduction mechanisms];
Pssm-ID: 441804 [Multi-domain] Cd Length: 258 Bit Score: 52.72 E-value: 2.41e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 374 RLAQRYAEADQRLADAIESTSEAFVLWDKNDRLVMCNTHYQKAYGLPDSVLVAgtekstvyaaaaRPVVERRVADPDQSG 453
Cdd:COG2202 1 TAEEALEESERRLRALVESSPDAIIITDLDGRILYVNPAFERLTGYSAEELLG------------KTLRDLLPPEDDDEF 68
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 549125420 454 LSRTTEVQLADDRWLQINERRTRDG--------------------GLVSVGTDITLLKRHQERLRDSERRL 504
Cdd:COG2202 69 LELLRAALAGGGVWRGELRNRRKDGslfwvelsispvrdedgeitGFVGIARDITERKRAEEALRESEERL 139
|
|
| COG3920 |
COG3920 |
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ... |
619-771 |
3.65e-07 |
|
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];
Pssm-ID: 443125 [Multi-domain] Cd Length: 495 Bit Score: 53.37 E-value: 3.65e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 619 NRETIDLAPLIEETLRLTAIQAEQKNITVqqkvcaglTMQGDRRAMKQ-------IMLN-LLSNAVKF---TGDGGSIAL 687
Cdd:COG3920 355 DWEGVDLRDYLRELLEPLRDSYGGRGIRI--------ELDGPDVELPAdaavplgLILNeLVTNALKHaflSGEGGRIRV 426
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 688 RTHVHEAAMILTIADTGIGIPTQalekigqpfeqvqsqyAKSQGGSGLGLAISRSLVKLHGGTMKIRSceGRGTVVTIII 767
Cdd:COG3920 427 SWRREDGRLRLTVSDNGVGLPED----------------VDPPARKGLGLRLIRALVRQLGGTLELDR--PEGTRVRITF 488
|
....
gi 549125420 768 PHAA 771
Cdd:COG3920 489 PLAE 492
|
|
| HATPase_EL346-LOV-HK-like |
cd16951 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
662-768 |
1.31e-06 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Erythrobacter litoralis blue light-activated histidine kinase 2; This domain family includes the histidine kinase-like ATPase (HATPase) domain of blue light-activated histidine kinase 2 of Erythrobacter litoralis (EL346). Signaling commonly occurs within HK dimers, however EL346 functions as a monomer. Also included in this family are the HATPase domains of ethanolamine utilization sensory transduction histidine kinase (EutW), whereby regulation of ethanolamine, a carbon and nitrogen source for gut bacteria, results in autophosphorylation and subsequent phosphoryl transfer to a response regulator (EutV) containing an RNA-binding domain. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory PAS sensor domain, while some have an N-terminal histidine kinase domain.
Pssm-ID: 340427 [Multi-domain] Cd Length: 131 Bit Score: 48.18 E-value: 1.31e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 662 RAMKQIML--NLLSNAVK--FTG-DGGSIALRTHVHEAAMILTIADTGIGIPtqalekigqpfeqvqsQYAKSQGGSGLG 736
Cdd:cd16951 36 VATAIGLVvnELLQNALKhaFSDrEGGTITIRSVVDGDYLRITVIDDGVGLP----------------QDEDWPNKGSLG 99
|
90 100 110
....*....|....*....|....*....|..
gi 549125420 737 LAISRSLVKLHGGTMKIRSCEGRGTVVTIIIP 768
Cdd:cd16951 100 LQIVRSLVEGELKAFLEVQSAENGTRVNIDIP 131
|
|
| PRK11086 |
PRK11086 |
sensory histidine kinase DcuS; Provisional |
670-768 |
4.85e-06 |
|
sensory histidine kinase DcuS; Provisional
Pssm-ID: 236839 [Multi-domain] Cd Length: 542 Bit Score: 49.91 E-value: 4.85e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 670 NLLSNAVKFTG--DGGSIALRTHVHEAAMILTIADTGIGIPTQALEKIgqpFEQVQSqyakSQG-GSGLGLAISRSLVKL 746
Cdd:PRK11086 440 NLIENALEAVGgeEGGEISVSLHYRNGWLHCEVSDDGPGIAPDEIDAI---FDKGYS----TKGsNRGVGLYLVKQSVEN 512
|
90 100
....*....|....*....|..
gi 549125420 747 HGGTMKIRSCEGRGTVVTIIIP 768
Cdd:PRK11086 513 LGGSIAVESEPGVGTQFFVQIP 534
|
|
| HATPase_ETR2_ERS2-EIN4-like |
cd16938 |
Histidine kinase-like ATPase domain of Arabidopsis thaliana ETR2, ERS2, and EIN4, and related ... |
659-767 |
5.41e-06 |
|
Histidine kinase-like ATPase domain of Arabidopsis thaliana ETR2, ERS2, and EIN4, and related domains; This family includes the histidine kinase-like ATPase domains (HATPase) of three out of the five receptors that recognize the plant hormone ethylene in Arabidopsis thaliana. These three proteins have been classified as belonging to subfamily 2: ETR2, ERS2, and EIN4. They lack most of the motifs characteristic of histidine kinases, and EIN4 is the only one in this group containing the conserved histidine that is phosphorylated in two-component and phosphorelay systems. This family also includes the HATPase domains of Escherichia coli RcsD phosphotransferase which is a component of the Rcs-signaling system, a complex multistep phosphorelay involving five proteins, and is involved in many transcriptional networks such as cell division, biofilm formation, and virulence, among others. Also included is Schizosaccharomyces pombe Mak3 (Phk1) which participates in a multi-step two-component related system which regulates H2O2-induced activation of the Sty1 stress-activated protein kinase pathway. Most proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a GAF sensor domain; most are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340415 [Multi-domain] Cd Length: 133 Bit Score: 46.68 E-value: 5.41e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 659 GDRRAMKQIMLNLLSNAVKFTGDGGSIALR-------THVHEAAMI--------------LTIADTGIGIPTQALEKIgq 717
Cdd:cd16938 7 GDERRVFQVLLHMLGNLLKMRNGGGNITFRvfleggsEDRSDRDWGpwrpsmsdesveirFEVEINDSGSPSIESASM-- 84
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 549125420 718 pFEQVQSQYAKSQGGSGLGLAISRSLVKLHGGTMKIRSCEGRGTVVTIII 767
Cdd:cd16938 85 -RNSLNRRYNLSELGEHLSFSICKQLVQLMGGNIWIVPGSGLGTTMSLLL 133
|
|
| HATPase_UhpB-NarQ-NarX-like |
cd16917 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
672-768 |
5.67e-06 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli UhpB, NarQ and NarX, and Bacillus subtilis YdfH, YhcY and YfiJ; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli UhpB, a HK of the UhpB-UhpA TCS, NarQ and NarX, HKs of the NarQ-NarP and NarX-NarL TCSs, respectively, and Bacillus YdfH, YhcY and YfiJ HKs, of the YdfH-YdfI, YhcY-YhcZ and YfiJ-YfiK TCSs, respectively. In addition, it includes Bacillus YxjM, ComP, LiaS and DesK, HKs of the YxjM-YxjML, ComP-ComA, LiaS-LiaR, DesR-DesK TCSs, respectively. Proteins having this HATPase domain have a histidine kinase dimerization and phosphoacceptor domain; some have accessory domains such as GAF, HAMP, PAS and MASE sensor domains.
Pssm-ID: 340394 [Multi-domain] Cd Length: 87 Bit Score: 45.24 E-value: 5.67e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 672 LSNAVKFTGdGGSIALRTHVHEAAMILTIADTGIGIptqalekigqpfeqvqsQYAKSQGGSGLGLAISRSLVKLHGGTM 751
Cdd:cd16917 9 LTNALKHAG-ASRVRVTLSYTADELTLTVVDDGVGF-----------------DGPAPPGGGGFGLLGMRERAELLGGTL 70
|
90
....*....|....*..
gi 549125420 752 KIRSCEGRGTVVTIIIP 768
Cdd:cd16917 71 TIGSRPGGGTRVTARLP 87
|
|
| RsbW |
COG2172 |
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; |
671-768 |
1.60e-05 |
|
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
Pssm-ID: 441775 [Multi-domain] Cd Length: 127 Bit Score: 44.90 E-value: 1.60e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 671 LLSNAVKFTGDG---GSIALRTHVHEAAMILTIADTGIGIPtqaLEKIGQPFEqvqsqyakSQGGSGLGLAISRSLVKlh 747
Cdd:COG2172 42 AVTNAVRHAYGGdpdGPVEVELELDPDGLEIEVRDEGPGFD---PEDLPDPYS--------TLAEGGRGLFLIRRLMD-- 108
|
90 100
....*....|....*....|.
gi 549125420 748 ggTMKIRSCEGrGTVVTIIIP 768
Cdd:COG2172 109 --EVEYESDPG-GTTVRLVKR 126
|
|
| PAC |
smart00086 |
Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); PAC motif ... |
332-372 |
4.24e-05 |
|
Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); PAC motif occurs C-terminal to a subset of all known PAS motifs. It is proposed to contribute to the PAS domain fold.
Pssm-ID: 197509 Cd Length: 43 Bit Score: 41.40 E-value: 4.24e-05
10 20 30 40
....*....|....*....|....*....|....*....|...
gi 549125420 332 DQIFRMRHTKGHYVWLRARAQVIRTNNG--PRVIGIAMDVTEQ 372
Cdd:smart00086 1 TVEYRLRRKDGSYIWVLVSASPIRDEDGevEGILGVVRDITER 43
|
|
| dpiB |
PRK15053 |
sensor histidine kinase DpiB; Provisional |
667-768 |
5.76e-05 |
|
sensor histidine kinase DpiB; Provisional
Pssm-ID: 185013 [Multi-domain] Cd Length: 545 Bit Score: 46.36 E-value: 5.76e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 667 IMLNLLSNA----VKFTGDGGSIALRTHVHEAAMILTIADTGIGIPTQALEKIgqpFEQVQSQYAKSQGGSGLGLAISRS 742
Cdd:PRK15053 436 IVGNLLDNAfeasLRSDEGNKIVELFLSDEGDDVVIEVADQGCGVPESLRDKI---FEQGVSTRADEPGEHGIGLYLIAS 512
|
90 100
....*....|....*....|....*.
gi 549125420 743 LVKLHGGTMKIRSCEGRGTVVTIIIP 768
Cdd:PRK15053 513 YVTRCGGVITLEDNDPCGTLFSIFIP 538
|
|
| HATPase_Phy-like |
cd16932 |
Histidine kinase-like ATPase domain of plant phytochromes similar to Arabidopsis thaliana ... |
659-752 |
1.52e-04 |
|
Histidine kinase-like ATPase domain of plant phytochromes similar to Arabidopsis thaliana Phytochrome A, B, C, D and E; This family includes the histidine kinase-like ATPase (HATPase) domains of plant red/far-red photoreceptors, the phytochromes, and includes the Arabidopsis thaliana phytochrome family phyA-phyE. Following red light absorption, biologically inactive forms of phytochromes convert to active forms, which rapidly convert back to inactive forms upon far-red light irradiation. Phytochromes can be considered as having an N-terminal photosensory region to which a bilin chromophore is bound, and a C-terminal output region, which includes the HATPase domain represented here, and is involved in dimerization and presumably contributes to relaying the light signal to downstream signaling events.
Pssm-ID: 340409 [Multi-domain] Cd Length: 113 Bit Score: 41.87 E-value: 1.52e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 659 GDRRAMKQIMLNLLSNAVKFT-GDGGSI---------ALRTHVHEAAMILTIADTGIGIPTqalekigqpfEQVQSQYAK 728
Cdd:cd16932 2 GDQIRLQQVLADFLLNAVRFTpSPGGWVeikvsptkkQIGDGVHVIHLEFRITHPGQGLPE----------ELVQEMFEE 71
|
90 100
....*....|....*....|....*.
gi 549125420 729 SQGGS--GLGLAISRSLVKLHGGTMK 752
Cdd:cd16932 72 NQWTTqeGLGLSISRKLVKLMNGDVR 97
|
|
| PRK13560 |
PRK13560 |
hypothetical protein; Provisional |
318-561 |
1.10e-03 |
|
hypothetical protein; Provisional
Pssm-ID: 106506 [Multi-domain] Cd Length: 807 Bit Score: 42.35 E-value: 1.10e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 318 ELARAVGCGNLRQIDQIFRM-RHTKGHYVWlraraqvirtnngprvIGIAMDVTEQHRLAQRYAEADQRLADAIESTSEA 396
Cdd:PRK13560 153 EEEGHFRCGDGRFIDCCLRFeRHAHADDQV----------------DGFAEDITERKRAEERIDEALHFLQQLLDNIADP 216
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 397 FVLWDKNDRLVMCNTHYQKAYGLPDSVLVAGT--EKSTVYAAAARPVVERRVADPDQS-----------GLSRTTEVQLA 463
Cdd:PRK13560 217 AFWKDEDAKVFGCNDAACLACGFRREEIIGMSihDFAPAQPADDYQEADAAKFDADGSqiieaefqnkdGRTRPVDVIFN 296
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 464 DdrwLQINERRTRDGGLVSVGTDITLLKRHQERLRDSERRLMATIGDLSASQHKLErqktelSDANA----NYLAEKERA 539
Cdd:PRK13560 297 H---AEFDDKENHCAGLVGAITDISGRRAAERELLEKEDMLRAIIEAAPIAAIGLD------ADGNIcfvnNNAAERMLG 367
|
250 260
....*....|....*....|..
gi 549125420 540 QAANRAKSEFLANMSHELRTPL 561
Cdd:PRK13560 368 WSAAEVMGKPLPGMDPELNEEF 389
|
|
| HATPase_LytS-like |
cd16957 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
671-768 |
1.98e-03 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis LytS and Staphylococcus aureus LytS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis LytS, a HK of the two-component system (TCS) LytS-LytR needed for growth on pyruvate, and Staphylococcus aureus LytS-LytR TCS involved in the adaptation of S. aureus to cationic antimicrobial peptides. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), and a GAF sensor domain; most contain a DUF3816 domain.
Pssm-ID: 340433 [Multi-domain] Cd Length: 106 Bit Score: 38.56 E-value: 1.98e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 671 LLSNAVK--FTG--DGGSIALRTHVHEAAMILTIADTGIGIPTQALEKIGQpfEQVQSQyaksqggSGLGLA---ISRSL 743
Cdd:cd16957 9 LVENAIRhaFPKrkENNEVRVVVKKDQHKVHVSVSDNGQGIPEERLDLLGK--TTVTSE-------KGTGTAlenLNRRL 79
|
90 100
....*....|....*....|....*..
gi 549125420 744 VKLHG--GTMKIRSCEGRGTVVTIIIP 768
Cdd:cd16957 80 IGLFGseACLHIESEVHGGTEVWFVIP 106
|
|
| PRK11644 |
PRK11644 |
signal transduction histidine-protein kinase/phosphatase UhpB; |
672-768 |
2.05e-03 |
|
signal transduction histidine-protein kinase/phosphatase UhpB;
Pssm-ID: 236945 [Multi-domain] Cd Length: 495 Bit Score: 41.50 E-value: 2.05e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549125420 672 LSNAVKFtGDGGSIALRTHVHEAAMILTIADTGIGIPTQALEKigqpfeqvqsqyaksqggsGLGLAISRSLVKLHGGTM 751
Cdd:PRK11644 419 LNNIVKH-ADASAVTLQGWQQDERLMLVIEDDGSGLPPGSGQQ-------------------GFGLRGMRERVTALGGTL 478
|
90
....*....|....*..
gi 549125420 752 KIrSCEgRGTVVTIIIP 768
Cdd:PRK11644 479 TI-SCT-HGTRLSVSLP 493
|
|
| |
