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Conserved domains on  [gi|557141991|emb|CDJ40474|]
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hypothetical protein, conserved [Eimeria tenella]

Protein Classification

dublecortin domain-containing protein( domain architecture ID 13074121)

dublecortin (DCX) domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DCX cd01617
Dublecortin-like domain structurally similar to a beta-grasp ubiquitin-like fold; Dublecortin ...
 182-253 6.90e-24

Dublecortin-like domain structurally similar to a beta-grasp ubiquitin-like fold; Dublecortin (DCX) is a microtubule-associated protein (MAP) with a stable ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. The DCX gene family consists of eleven paralogs in human and mouse, and its DCX protein domains can occur in double tandem or as single DCX repeats. Proteins with DCX tandem domains in general have roles in microtubule (MT) regulation and signal transduction such as X-linked doublecortin (DCX), retinitis pigmentosa-1 (RP1) and doublecortin-like kinase (DCLK). Single DCX repeat proteins are normally localized to actin-rich subcellular structures, or the nucleus such as DCDC2. DCX is not only a unique MAP in terms of structure, it also interacts with multiple additional proteins. Mutations in human DCX genes are associated with abnormal neuronal migration, epilepsy, and mental retardation.


:

Pssm-ID: 340456  Cd Length: 73  Bit Score: 91.91  E-value: 6.90e-24
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 557141991 182 RLLWLFRNGDKHHDGTPFFVKSH-IRTLEALYQELTKVITPIAGPVRRLYDQNLRLVVDLADLVDGAKYLCTS 253
Cdd:cd01617    1 KRITVFRNGDKNFKGVKVLVKPRrFRTFDQLLDELTEKLGLPTGGVRKLYTPSGKLVKSLSDLEDGESYVVCG 73
p25-alpha super family cl05205
p25-alpha; This family encodes a 25 kDa protein that is phosphorylated by a Ser/Thr-Pro kinase. ...
 104-135 1.59e-09

p25-alpha; This family encodes a 25 kDa protein that is phosphorylated by a Ser/Thr-Pro kinase. It has been described as a brain specific protein, but it is found in Tetrahymena thermophila.


The actual alignment was detected with superfamily member pfam05517:

Pssm-ID: 461670  Cd Length: 155  Bit Score: 55.35  E-value: 1.59e-09
                          10        20        30
                  ....*....|....*....|....*....|..
gi 557141991  104 DRLTNSAFYTGVHRERFDELGNGRGLAGREYL 135
Cdd:pfam05517 112 DRLTDTSKYTGSHKERFDESGKGKGIAGREDR 143
 
Name Accession Description Interval E-value
DCX cd01617
Dublecortin-like domain structurally similar to a beta-grasp ubiquitin-like fold; Dublecortin ...
 182-253 6.90e-24

Dublecortin-like domain structurally similar to a beta-grasp ubiquitin-like fold; Dublecortin (DCX) is a microtubule-associated protein (MAP) with a stable ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. The DCX gene family consists of eleven paralogs in human and mouse, and its DCX protein domains can occur in double tandem or as single DCX repeats. Proteins with DCX tandem domains in general have roles in microtubule (MT) regulation and signal transduction such as X-linked doublecortin (DCX), retinitis pigmentosa-1 (RP1) and doublecortin-like kinase (DCLK). Single DCX repeat proteins are normally localized to actin-rich subcellular structures, or the nucleus such as DCDC2. DCX is not only a unique MAP in terms of structure, it also interacts with multiple additional proteins. Mutations in human DCX genes are associated with abnormal neuronal migration, epilepsy, and mental retardation.


Pssm-ID: 340456  Cd Length: 73  Bit Score: 91.91  E-value: 6.90e-24
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 557141991 182 RLLWLFRNGDKHHDGTPFFVKSH-IRTLEALYQELTKVITPIAGPVRRLYDQNLRLVVDLADLVDGAKYLCTS 253
Cdd:cd01617    1 KRITVFRNGDKNFKGVKVLVKPRrFRTFDQLLDELTEKLGLPTGGVRKLYTPSGKLVKSLSDLEDGESYVVCG 73
DCX smart00537
Domain in the Doublecortin (DCX) gene product; Tandemly-repeated domain in doublin, the ...
 181-263 9.32e-11

Domain in the Doublecortin (DCX) gene product; Tandemly-repeated domain in doublin, the Doublecortin gene product. Proposed to bind tubulin. Doublecortin (DCX) is mutated in human X-linked neuronal migration defects.


Pssm-ID: 214711  Cd Length: 89  Bit Score: 57.27  E-value: 9.32e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557141991   181 PRLLWLFRNGDKHHDGTPFFV-KSHIRTLEALYQELTKVIT-PIAGPVRRLYDQNLRLVVDLADLVDGAKYLCTSGEPPA 258
Cdd:smart00537   5 PKRIRFYRNGDRFFKGVRLVVnRKRFKSFEALLQDLTEVVKlDLPHGVRKLYTLDGKKVTSLDELEDGGSYVASGTEAFK 84


                   ....*
gi 557141991   259 CAERL 263
Cdd:smart00537  85 KVDYG 89
p25-alpha pfam05517
p25-alpha; This family encodes a 25 kDa protein that is phosphorylated by a Ser/Thr-Pro kinase. ...
 104-135 1.59e-09

p25-alpha; This family encodes a 25 kDa protein that is phosphorylated by a Ser/Thr-Pro kinase. It has been described as a brain specific protein, but it is found in Tetrahymena thermophila.


Pssm-ID: 461670  Cd Length: 155  Bit Score: 55.35  E-value: 1.59e-09
                          10        20        30
                  ....*....|....*....|....*....|..
gi 557141991  104 DRLTNSAFYTGVHRERFDELGNGRGLAGREYL 135
Cdd:pfam05517 112 DRLTDTSKYTGSHKERFDESGKGKGIAGREDR 143
DCX pfam03607
Doublecortin;
202-256 2.55e-09

Doublecortin;


Pssm-ID: 460986  Cd Length: 60  Bit Score: 52.45  E-value: 2.55e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 557141991  202 KSHIRTLEALYQELT-KVITPIAGPVRRLYDQNLRLVVDLADLVDGAKYLCTSGEP 256
Cdd:pfam03607   4 KRRFRSFDALLDELTeKVVKLPFGAVRKLYTLDGKRVTSLDELEDGGVYVAAGREK 59
 
Name Accession Description Interval E-value
DCX cd01617
Dublecortin-like domain structurally similar to a beta-grasp ubiquitin-like fold; Dublecortin ...
 182-253 6.90e-24

Dublecortin-like domain structurally similar to a beta-grasp ubiquitin-like fold; Dublecortin (DCX) is a microtubule-associated protein (MAP) with a stable ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. The DCX gene family consists of eleven paralogs in human and mouse, and its DCX protein domains can occur in double tandem or as single DCX repeats. Proteins with DCX tandem domains in general have roles in microtubule (MT) regulation and signal transduction such as X-linked doublecortin (DCX), retinitis pigmentosa-1 (RP1) and doublecortin-like kinase (DCLK). Single DCX repeat proteins are normally localized to actin-rich subcellular structures, or the nucleus such as DCDC2. DCX is not only a unique MAP in terms of structure, it also interacts with multiple additional proteins. Mutations in human DCX genes are associated with abnormal neuronal migration, epilepsy, and mental retardation.


Pssm-ID: 340456  Cd Length: 73  Bit Score: 91.91  E-value: 6.90e-24
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 557141991 182 RLLWLFRNGDKHHDGTPFFVKSH-IRTLEALYQELTKVITPIAGPVRRLYDQNLRLVVDLADLVDGAKYLCTS 253
Cdd:cd01617    1 KRITVFRNGDKNFKGVKVLVKPRrFRTFDQLLDELTEKLGLPTGGVRKLYTPSGKLVKSLSDLEDGESYVVCG 73
DCX smart00537
Domain in the Doublecortin (DCX) gene product; Tandemly-repeated domain in doublin, the ...
 181-263 9.32e-11

Domain in the Doublecortin (DCX) gene product; Tandemly-repeated domain in doublin, the Doublecortin gene product. Proposed to bind tubulin. Doublecortin (DCX) is mutated in human X-linked neuronal migration defects.


Pssm-ID: 214711  Cd Length: 89  Bit Score: 57.27  E-value: 9.32e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557141991   181 PRLLWLFRNGDKHHDGTPFFV-KSHIRTLEALYQELTKVIT-PIAGPVRRLYDQNLRLVVDLADLVDGAKYLCTSGEPPA 258
Cdd:smart00537   5 PKRIRFYRNGDRFFKGVRLVVnRKRFKSFEALLQDLTEVVKlDLPHGVRKLYTLDGKKVTSLDELEDGGSYVASGTEAFK 84


                   ....*
gi 557141991   259 CAERL 263
Cdd:smart00537  85 KVDYG 89
p25-alpha pfam05517
p25-alpha; This family encodes a 25 kDa protein that is phosphorylated by a Ser/Thr-Pro kinase. ...
 104-135 1.59e-09

p25-alpha; This family encodes a 25 kDa protein that is phosphorylated by a Ser/Thr-Pro kinase. It has been described as a brain specific protein, but it is found in Tetrahymena thermophila.


Pssm-ID: 461670  Cd Length: 155  Bit Score: 55.35  E-value: 1.59e-09
                          10        20        30
                  ....*....|....*....|....*....|..
gi 557141991  104 DRLTNSAFYTGVHRERFDELGNGRGLAGREYL 135
Cdd:pfam05517 112 DRLTDTSKYTGSHKERFDESGKGKGIAGREDR 143
DCX pfam03607
Doublecortin;
202-256 2.55e-09

Doublecortin;


Pssm-ID: 460986  Cd Length: 60  Bit Score: 52.45  E-value: 2.55e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 557141991  202 KSHIRTLEALYQELT-KVITPIAGPVRRLYDQNLRLVVDLADLVDGAKYLCTSGEP 256
Cdd:pfam03607   4 KRRFRSFDALLDELTeKVVKLPFGAVRKLYTLDGKRVTSLDELEDGGVYVAAGREK 59
DCX2_DCDC2_like cd16113
Doublecortin-like domain 2 found in doublecortin domain-containing protein 2 (DCDC2); DCDC2 is ...
 181-249 1.74e-08

Doublecortin-like domain 2 found in doublecortin domain-containing protein 2 (DCDC2); DCDC2 is a member of the doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of a ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC2 genetic variation in humans is associated with reading disability, attention deficit hyperactivity disorder (ADHD), and difficulties in mathematics. A genetic variant of DCDC2 associates with dyslexia, a common neurobehavioral disorder of reading. DCDC2 protein interacts with many of the same cytoskeleton related proteins that other members of the DCX family interact with.


Pssm-ID: 340530  Cd Length: 74  Bit Score: 50.27  E-value: 1.74e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557141991 181 PRLLWLFRNGDKHHDGTPFFVKSHI-RTLEALYQELTKVITPIAGPVRRLYDQNLRLVVDLADLVDGAKY 249
Cdd:cd16113    1 PKTIHVFPNGDLLHPPSKVLLTKRRlPNWDTVLEEVTEKVKLQTGAVRKLYTLDGKRISDPDELVNGGQY 70
DCX1_DCDC2_like cd17071
Dublecortin-like domain 1 found in doublecortin domain-containing protein 2 (DCDC2) and ...
 186-255 1.97e-08

Dublecortin-like domain 1 found in doublecortin domain-containing protein 2 (DCDC2) and similar proteins; DCDC2 is a member of the doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC2 genetic variation in humans is associated with reading disability, attention deficit hyperactivity disorder (ADHD), and difficulties in mathematics. A genetic variant of DCDC2 associates with dyslexia, a common neurobehavioral disorder of reading. DCDC2 protein interacts with many of the same cytoskeleton related proteins that other members of the DCX family interact with.


Pssm-ID: 340591  Cd Length: 80  Bit Score: 50.30  E-value: 1.97e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 557141991 186 LFRNGDKHHDGTPFFV-KSHIRTLEALYQELTKVITPIAGPVRRLYDQNLR-LVVDLADLVDGAKYLCTSGE 255
Cdd:cd17071    5 VYKNGDPFFPGKKFVVnERQVRTFDAFLNEVTSGIKAPFGAVRSIYTPTGGhRVKDLDSLQNGGVYVAAGSE 76
DCX1 cd16109
Dublecortin-like domain 1; Members of the doublecortin (DCX) gene family are ...
 187-256 1.77e-06

Dublecortin-like domain 1; Members of the doublecortin (DCX) gene family are microtubule-associated proteins (MAPs). Microtubules are key components of cytoskeleton that are involved in cell movement, shape determination, division and transport. The DCX gene family consists of eleven paralogs in human and mouse, and its protein domains can occur in double tandem or single repeats. The family represents the first repeat of the DCX domain which has a stable ubiquitin-like tertiary fold. Proteins with DCX double tandem domains in general have roles in microtubule (MT) regulation and signal transduction such as X-linked doublecortin (DCX), retinitis pigmentosa-1 (RP1) and doublecortin-like kinase (DCLK).


Pssm-ID: 340526  Cd Length: 85  Bit Score: 44.98  E-value: 1.77e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 557141991 187 FRNGDKHHDGTPFFVKS-HIRTLEALYQELTKVI---TPIAGPVRRLYD-QNLRLVVDLADLVDGAKYLCTSGEP 256
Cdd:cd16109    8 YRNGDRFFKGIVYAVSSeRFRSFEALLADLTRSLsdnVNLPQGVRTIFTiDGSRKITSLDELEDGESYVCASTDA 82
DCX1_DCLK2 cd17141
Dublecortin-like domain 1 found in doublecortin-like kinase 2 (DCLK2); DCLK2 is a member of ...
 186-256 3.22e-06

Dublecortin-like domain 1 found in doublecortin-like kinase 2 (DCLK2); DCLK2 is a member of doublecortin (DCX) protein superfamily that functions as a microtubule-associated protein (MAP), and contains two conserved tubulin binding domains, which typically occur in tandem. The DCX domain has a stable ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier (Ubiquitination) in eukaryotes that is involved in various cellular processes including transcriptional regulation, cell cycle control, and DNA repair. In addition to microtubule binding domains, DCLK encodes a serine/threonine kinase-domain that is similar to Ca/calmodulin-dependent (Cam) protein kinases. Molecular actions of DCX members are less well characterized and it shows that DCLK2 members regulate cyclic AMP signaling. Unlike DCX, this DCLK has varying levels of expression throughout embryonic and adult life.


Pssm-ID: 340661  Cd Length: 85  Bit Score: 44.51  E-value: 3.22e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 557141991 186 LFRNGDKHHDGTPFFVKS-HIRTLEALYQELTKVITP---IAGPVRRLY--DQNLRlVVDLADLVDGAKYLCTSGEP 256
Cdd:cd17141    7 FYRNGDRYFKGLVYAVSSdRFRSFDALLMELTRSLSDnvnLPQGVRTIYtiDGSKK-ITSLDELLEGESYVCASNEP 82
DCX1_DCDC2C cd17151
Dublecortin-like domain 1 found in doublecortin domain-containing protein 2C (DCDC2C); DCDC2 ...
 186-255 1.85e-05

Dublecortin-like domain 1 found in doublecortin domain-containing protein 2C (DCDC2C); DCDC2 is a member of doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of ubiquitin-like tertiary fold. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC2 genetic variation in humans is associated with reading disability, attention deficit hyperactivity disorder (ADHD), and difficulties in mathematics. A genetic variant of DCDC2 associates with dyslexia, a common neurobehavioral disorder of reading. DCDC2 protein interacts with many of the same cytoskeleton related proteins that other members of the DCX family interact with.


Pssm-ID: 340671  Cd Length: 79  Bit Score: 42.08  E-value: 1.85e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 557141991 186 LFRNGDKHHDGTPFFV-KSHIRTLEALYQELTKVITPIAGpVRRLYD-QNLRLVVDLADLVDGAKYLCTSGE 255
Cdd:cd17151    5 VYRNGDPFYQAHKVVIhRRRVKTFDALLRQLTETVKVPFG-VRCLYTpRNGHRVKGLDDLQGGGKYVAAGRE 75
DCX1_DCLK1 cd17140
Dublecortin-like domain 1 found in doublecortin-like kinase 1 (DCLK1); DCLK1 is a member of ...
 186-256 5.61e-05

Dublecortin-like domain 1 found in doublecortin-like kinase 1 (DCLK1); DCLK1 is a member of doublecortin (DCX) protein superfamily that functions as a microtubule-associated protein (MAP), and contains two conserved tubulin binding domains. The DCX domain has a stable ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. In addition to microtubule-binding domains, DCLK encodes a serine/threonine kinase domain that is similar to Ca/calmodulin-dependent (Cam) protein kinases. DCLK1 appears to regulate cyclic AMP signaling and is involved in neuronal migration, retrograde transport, neuronal apoptosis and neurogenesis. Unlike DCX, this DCLK has varying levels of expression throughout embryonic and adult life.


Pssm-ID: 340660  Cd Length: 89  Bit Score: 41.14  E-value: 5.61e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 557141991 186 LFRNGDKHHDGTPFFV-KSHIRTLEALYQELTKVITP---IAGPVRRLYD-QNLRLVVDLADLVDGAKYLCTSGEP 256
Cdd:cd17140    7 FYRNGDRYFKGIVYAIsPDRFRSFEALLADLTRTLSDnvnLPQGVRTIYTiDGLKKISSLDQLVEGESYVCGSIEP 82
DCX2_RP_like cd17070
Dublecortin-like domain 2 found in retinitis pigmentosa (RP)-like protein; RP-like protein ...
 182-246 3.40e-03

Dublecortin-like domain 2 found in retinitis pigmentosa (RP)-like protein; RP-like protein family is part of doublecortin (DCX) superfamily with double tandem DCX repeats that are associated with retinitis pigmentosa. DCX is a microtubule-associated protein (MAP) with a stable ubiquitin-like tertiary fold. Microtubules are key components of cytoskeleton that are involved in cell movement, shape determination, division and transport. RP-like proteins are colocalized to the photoreceptor and share a function in outer segment disc morphogenesis.


Pssm-ID: 340590  Cd Length: 69  Bit Score: 35.30  E-value: 3.40e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 557141991 182 RLLWLFRNGDKHHDGTPFFVKSHIRTLEALYQELTKVITPiagPVRRLYDQNLRLVVDLADLVDG 246
Cdd:cd17070    1 KVITVISNGDPHSRHTILLNRRTTQSFEQVLQDLSELLKG---PVRKLYTTDGKKVESLSALFHG 62
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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