|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_MFSD3 |
cd17485 |
Major facilitator superfamily domain containing 3 protein; Major facilitator superfamily ... |
17-396 |
1.12e-113 |
|
Major facilitator superfamily domain containing 3 protein; Major facilitator superfamily domain containing 3 protein (MFSD3) is a predicted acetyl-CoA transporter. As an atypical putative membrane-bound solute carrier (SLC), MFSD3 is most likely to be functionally active in the plasma membrane and not in any intracellular organelles. MFSD3 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341038 [Multi-domain] Cd Length: 386 Bit Score: 337.66 E-value: 1.12e-113
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 582006829 17 VIVVLYLAHALPLYFFNVAMPAILRSQGVDLRWIGMLSLLYLPWAFKFLWAPLVDRHYLHSLGRRRTWLWLTQAALVAGI 96
Cdd:cd17485 1 LLFGLYLAQGLPYGFQSQALPVLLRSAGVSLTAIGLLKLLYLPWVLKFLWAPLVDRYGLPRLGRRRSWLLPTQLGLALLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 582006829 97 LLLALTGLEHGLLLFVLVSLWISTFAATQDIAIDGYTVESLASDDHRLGSMAQSIGVALGSMFGGAGVLWLYQVVGWQSA 176
Cdd:cd17485 81 LALAFLPPTTNLLAFLGLLFLLNLFSATQDIATDGLAVELLTPEERGLGNAAQVVGYKLGSLLGGGGLLWLYDLIGWQSL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 582006829 177 LLTLAGLSALTMLAVARVDDRLPAQAE-------AARPGFIATFKRPEIRWALLLILVYRLVEAPAMAMLTPMLVDRQWS 249
Cdd:cd17485 161 LLSLAALYLLLLLPVLFLRELELPQQPpasergaALKASLRAFLRRPGTRWLLLFLLLYKLGEQGALAMLPPFLVDRGFS 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 582006829 250 LTQIGLLMSVAGASVGLLAAVAAARLLQRQRAATLLLRAGWLRSLAYLAVAgLLLSGLADGSPLWLGAMVLVLLAIRYLA 329
Cdd:cd17485 241 LSQIGLLSGVGGSLVSIAGSLLGGYLLKRRGRRRLLLLGGLLRLLLLGLYT-LLALGGSGLNWVLLLASLALLHLVGGMI 319
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 582006829 330 MTSLYALFMQLCSRQQAGTDFTVLVCFELLVFFVGGSLSGFLAKGLGYETYYLLLGALSVLSVLLCK 396
Cdd:cd17485 320 TTALFTLMMDCSQQAQAGTDYTLLATVEVLGKLLFGSLAGFLADHLGYAAAFLLFAILSALSVLLLL 386
|
|
| sider_RhtX_FptX |
TIGR02718 |
siderophore transporter, RhtX/FptX family; RhtX from Sinorhizobium meliloti 2011 and FptX from ... |
16-394 |
7.00e-48 |
|
siderophore transporter, RhtX/FptX family; RhtX from Sinorhizobium meliloti 2011 and FptX from Pseudomonas aeruginosa appear to be single polypeptide transporters, from the major facilitator family (see pfam07690) for import of siderophores as a means to import iron. This function was suggested by proximity to siderophore biosynthesis genes and then confirmed by study of knockout and heterologous expression phenotypes. [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 131765 Cd Length: 390 Bit Score: 167.76 E-value: 7.00e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 582006829 16 AVIVVLYLAHALPLYFFNVAMPAILRSQGVDLRWIGMLSLLYLPWAFKFLWAPLVDRHYLHSLGRRRTWLWLTQAALVAG 95
Cdd:TIGR02718 4 ITLGLLYLSQGIPIGLAMDALPTLLREDGAPLTALAFLPLVGLPWVVKFLWAPLVDNWWSWRLGRRRSWVLPMQCLVSAC 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 582006829 96 ILLLALTGLEHGLLLFVLVSLWISTFA-ATQDIAIDGYTVESLASDDHRLGSMAQSIGVALGSMFGGAGVLWLYQVVGWQ 174
Cdd:TIGR02718 84 LASLALVGPDVAGAGWAVGLLACASLAsATQDIATDGMAAEHFNGRTLAKGNAVQIAGVMIGFFGGGAGTLVLFGKFGQR 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 582006829 175 SALLTLAGLSALTMLAVARVDDRLPAQAEAA---RPGFIATFKRPEIRWALLLILVYRLVEAPAMAMLTPMLVDRQWSLT 251
Cdd:TIGR02718 164 PAFLLVACVPLASLVCVLWLKDRAVASPEAPlarRASLFRFFRRPLAWSLLALALLSAMTAVSGFGLSKLYLVDAGWPLE 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 582006829 252 QIGLLMSVAGASVGLLAAVAaarllqrqrAATLLLRAGWLRSLAY---LAVAGLLLSGLADGSPLWLG---AMVLVLLA- 324
Cdd:TIGR02718 244 WIGRLGMAGGAVTVLLGCGG---------GAWLVRRAGLWRTFILgvgLAGSLALLWFAQAAFWLAPGiavAWSCSAFGs 314
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 582006829 325 -IRYLAMTSLYALFMQLCSRQ-QAGTDFTVLVCFELLVFFVGGSLSGFLAKGLGYETYYLLLGALSVLSVLL 394
Cdd:TIGR02718 315 lITGITSVAIYTAFMRFAGDGdQAGTDVTAVQSTRDLGELIASSIAGYLTDRFGYAGGFLSGTVLAVLAILL 386
|
|
| ampG |
PRK11902 |
muropeptide transporter; Reviewed |
15-394 |
1.31e-28 |
|
muropeptide transporter; Reviewed
Pssm-ID: 183369 [Multi-domain] Cd Length: 402 Bit Score: 115.72 E-value: 1.31e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 582006829 15 LAVIVVLYLAHALPLYFFNVAMPAILRSQGVDLRWIGMLSLLYLPWAFKFLWAPLVDRHYLHSLGRRRTWLWLTQAALVA 94
Cdd:PRK11902 1 IGAMLLLGFASGLPLALTSGTLQAWMTVEGLDIQTIGFFSLVGQAYIFKFLWAPLMDRYTPPLLGRRRGWLLLTQVGLAA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 582006829 95 GILLLALTGLEHGLLLFVLVSLWISTFAATQDIAIDGYTVESLASDDHRLGSMAQSIGVALGSMFGGAGVLWLY-QVVGW 173
Cdd:PRK11902 81 SIAAMAFCPPHAALWPLAGLAVLVAFLSASQDIVFDAYSTDVLHPEERGAGAAVKVLGYRLAMLVSGGLALWLAdRVLGW 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 582006829 174 QSALLTLAGLSALTMLAV-----ARVDDRLPAQAEAARPG-FIATFKRPEIRWALLLILVYRLVEAPAMAMLTPMLV-DR 246
Cdd:PRK11902 161 GNTYLLMAGLMLAGALTTlwapePEVPARPPRSLGEAVVGpLRDFFSRRGAWALLLLIVLYKLGDAFAGSLSTTFLIrGA 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 582006829 247 QWSLTQIGLLMSVAGASVGLLAAVAaarllqrqrAATLLLRAGWLRSL----AYLAVAGLLLSGLADGSP-LWL-GAMVL 320
Cdd:PRK11902 241 GFSAGEVGIVNKTLGLAATIVGALA---------GGTLMVRLGLYRSLmlfgVLQAVSNLGYWVLAVTPKhLWTmALAIG 311
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 582006829 321 VLLAIRYLAMTSLYALFMQLCSRQQAGTDFTVLVCFELLVFFVGGSLSGFLAKGLGYETYYLLLGALSVLSVLL 394
Cdd:PRK11902 312 IENLCGGMGTAAFVALLMALCNRSFSATQYALLSALASVGRVYVGPTSGYLVEAYGWPGFYLMTVVIALPGLAL 385
|
|
| Acatn |
pfam13000 |
Acetyl-coenzyme A transporter 1; The mouse Acatn is a 61 kDa hydrophobic protein with six to ... |
18-156 |
3.56e-15 |
|
Acetyl-coenzyme A transporter 1; The mouse Acatn is a 61 kDa hydrophobic protein with six to 10 transmembrane domains. It appears to promote 9-O-acetylation in gangliosides.
Pssm-ID: 372424 [Multi-domain] Cd Length: 543 Bit Score: 77.02 E-value: 3.56e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 582006829 18 IVVLYLAHALPLYFFNVAMPAILRSQGVDLRW--IGMLSLLYLPWAFKFLWAPLVDRHYLHSLGRRRTWLWLTQaaLVAG 95
Cdd:pfam13000 4 LVALYFLQGIPVGLAFGTIPFLLKSMAKETSFtsLGIFSMATYPYSLKILWSPIVDSIYSKKIGRRRSWIIPVQ--LVSG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 582006829 96 ILLLAL----------TGLE---HGLLLFVLVSLWISTFA----------ATQDIAIDGYTVESLASDDHRLGSMAQSIG 152
Cdd:pfam13000 82 IMLIILgyciskglifPGVDdafHGRLSKGVLNVNITTLTwyfgilvflcATQDIAVDGWALTILSKQSLSYASTAQTVG 161
|
....
gi 582006829 153 VALG 156
Cdd:pfam13000 162 LNTG 165
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
11-348 |
3.17e-09 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 58.06 E-value: 3.17e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 582006829 11 TRLALAVIVVLYLAHALPLYFFNVAMPAILRSQGVDLRWIGMLSLLY-LPWA-FKFLWAPLVDRhylhsLGRRRTWLWlt 88
Cdd:COG2814 8 RWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYlLGAAlGAPLAGRLADR-----FGRRRVLLL-- 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 582006829 89 qaALVAGILLLALTGLEHGLLLFVLVSLWISTFAATQDIAIDGYTVESLASDDHRLGSMAQSIGVALGSMFGGAGVLWLY 168
Cdd:COG2814 81 --GLLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 582006829 169 QVVGWQSALLTLAGLSALTMLAVAR-VDDRLPAQAEAARPGFIATFKRPEIRWALLLILVYRLVEAPAMAMLTPMLVDR- 246
Cdd:COG2814 159 DLFGWRWVFLVNAVLALLALLLLLRlLPESRPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVl 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 582006829 247 QWSLTQIGLLMSVAGASVGLLAAVAAARLLQRQRAATLLLRAGwlrslayLAVAGLLLSGLADGSPLWLGAMVLVLLAIr 326
Cdd:COG2814 239 GLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLL-------LLALGLLLLALAGSLWLLLLALFLLGFGF- 310
|
330 340
....*....|....*....|..
gi 582006829 327 YLAMTSLYALFMQLCSRQQAGT 348
Cdd:COG2814 311 GLLFPLLQALVAELAPPEARGR 332
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_MFSD3 |
cd17485 |
Major facilitator superfamily domain containing 3 protein; Major facilitator superfamily ... |
17-396 |
1.12e-113 |
|
Major facilitator superfamily domain containing 3 protein; Major facilitator superfamily domain containing 3 protein (MFSD3) is a predicted acetyl-CoA transporter. As an atypical putative membrane-bound solute carrier (SLC), MFSD3 is most likely to be functionally active in the plasma membrane and not in any intracellular organelles. MFSD3 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341038 [Multi-domain] Cd Length: 386 Bit Score: 337.66 E-value: 1.12e-113
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 582006829 17 VIVVLYLAHALPLYFFNVAMPAILRSQGVDLRWIGMLSLLYLPWAFKFLWAPLVDRHYLHSLGRRRTWLWLTQAALVAGI 96
Cdd:cd17485 1 LLFGLYLAQGLPYGFQSQALPVLLRSAGVSLTAIGLLKLLYLPWVLKFLWAPLVDRYGLPRLGRRRSWLLPTQLGLALLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 582006829 97 LLLALTGLEHGLLLFVLVSLWISTFAATQDIAIDGYTVESLASDDHRLGSMAQSIGVALGSMFGGAGVLWLYQVVGWQSA 176
Cdd:cd17485 81 LALAFLPPTTNLLAFLGLLFLLNLFSATQDIATDGLAVELLTPEERGLGNAAQVVGYKLGSLLGGGGLLWLYDLIGWQSL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 582006829 177 LLTLAGLSALTMLAVARVDDRLPAQAE-------AARPGFIATFKRPEIRWALLLILVYRLVEAPAMAMLTPMLVDRQWS 249
Cdd:cd17485 161 LLSLAALYLLLLLPVLFLRELELPQQPpasergaALKASLRAFLRRPGTRWLLLFLLLYKLGEQGALAMLPPFLVDRGFS 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 582006829 250 LTQIGLLMSVAGASVGLLAAVAAARLLQRQRAATLLLRAGWLRSLAYLAVAgLLLSGLADGSPLWLGAMVLVLLAIRYLA 329
Cdd:cd17485 241 LSQIGLLSGVGGSLVSIAGSLLGGYLLKRRGRRRLLLLGGLLRLLLLGLYT-LLALGGSGLNWVLLLASLALLHLVGGMI 319
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 582006829 330 MTSLYALFMQLCSRQQAGTDFTVLVCFELLVFFVGGSLSGFLAKGLGYETYYLLLGALSVLSVLLCK 396
Cdd:cd17485 320 TTALFTLMMDCSQQAQAGTDYTLLATVEVLGKLLFGSLAGFLADHLGYAAAFLLFAILSALSVLLLL 386
|
|
| MFS_AmpG_like |
cd17486 |
AmpG and similar transporters of the Major Facilitator Superfamily; AmpG acts as an inner ... |
18-398 |
5.87e-54 |
|
AmpG and similar transporters of the Major Facilitator Superfamily; AmpG acts as an inner membrane permease in the beta-lactamase induction system and in peptidoglycan recycling. It transports meuropeptide from the periplasm into the cytosol in gram-negative bacteria, which is essential for the induction of the ampC encoding beta-lactamase. The AmpG family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341039 [Multi-domain] Cd Length: 387 Bit Score: 183.57 E-value: 5.87e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 582006829 18 IVVLYLAHALPLYFFNVAMPAILRSQGVDLRWIGMLSLLYLPWAFKFLWAPLVDRHYLHSLGRRRTWLWLTQAALVAGIL 97
Cdd:cd17486 1 ILLLGFASGLPYLLTGTTLQAWLKEAGVDLDTIGLFSLVGLPYSLKFLWAPLVDRYSTPFLGRRRGWILLTQILLMAALI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 582006829 98 LLALTGLEHGLLLFVLVSLWISTFAATQDIAIDGYTVESLASDDHRLGSMAQSIGVALGSMFGGAGVLWLYQVVGWQSAL 177
Cdd:cd17486 81 ALAFLDPFTNLVLSALLFLLVAFFSATQDIAIDAYRIEALEDKEQGAGAGVRVNGYRIGMLVAGAGALYLADSLSWSAVY 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 582006829 178 LTLAGLSALTMLA---------VARVDDRLPAQAEAARPGFIATFKRPEIRWALLLILVYRLVEAPAMAMLTPMLVDRQW 248
Cdd:cd17486 161 LIMAALMGPGILAtlfapepprTDPPANSLSETVVAFFAPFKDFFGQPGALLILAFILLYKLGDAMLGAMATPFLLDLGF 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 582006829 249 SLTQI-------GLLMSVAGASVGllaavaaarllqrqraATLLLRAGWLRSL----AYLAVAGLLLSGLAD-GSPLWLG 316
Cdd:cd17486 241 TKTEIgavyktvGLIATIVGGLLG----------------GFLMSRLGLKRSLwlfgILQALSNLGFIYLAHaGPNLTLL 304
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 582006829 317 AMVLVLLAIRY-LAMTSLYALFMQLCSRQQAGTDFTVLVCFELLVFFVGGSLSGFLAKGLGYETYYLLLGALSVLSVLLC 395
Cdd:cd17486 305 VAAVAVENFGGgLGTTAFVAYLMSLCNGEFTATQYALLSSLMALGRMVLGAPSGWLAEALGWTGFFLLTTLAAIPGLLLL 384
|
...
gi 582006829 396 KPI 398
Cdd:cd17486 385 LKV 387
|
|
| sider_RhtX_FptX |
TIGR02718 |
siderophore transporter, RhtX/FptX family; RhtX from Sinorhizobium meliloti 2011 and FptX from ... |
16-394 |
7.00e-48 |
|
siderophore transporter, RhtX/FptX family; RhtX from Sinorhizobium meliloti 2011 and FptX from Pseudomonas aeruginosa appear to be single polypeptide transporters, from the major facilitator family (see pfam07690) for import of siderophores as a means to import iron. This function was suggested by proximity to siderophore biosynthesis genes and then confirmed by study of knockout and heterologous expression phenotypes. [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 131765 Cd Length: 390 Bit Score: 167.76 E-value: 7.00e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 582006829 16 AVIVVLYLAHALPLYFFNVAMPAILRSQGVDLRWIGMLSLLYLPWAFKFLWAPLVDRHYLHSLGRRRTWLWLTQAALVAG 95
Cdd:TIGR02718 4 ITLGLLYLSQGIPIGLAMDALPTLLREDGAPLTALAFLPLVGLPWVVKFLWAPLVDNWWSWRLGRRRSWVLPMQCLVSAC 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 582006829 96 ILLLALTGLEHGLLLFVLVSLWISTFA-ATQDIAIDGYTVESLASDDHRLGSMAQSIGVALGSMFGGAGVLWLYQVVGWQ 174
Cdd:TIGR02718 84 LASLALVGPDVAGAGWAVGLLACASLAsATQDIATDGMAAEHFNGRTLAKGNAVQIAGVMIGFFGGGAGTLVLFGKFGQR 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 582006829 175 SALLTLAGLSALTMLAVARVDDRLPAQAEAA---RPGFIATFKRPEIRWALLLILVYRLVEAPAMAMLTPMLVDRQWSLT 251
Cdd:TIGR02718 164 PAFLLVACVPLASLVCVLWLKDRAVASPEAPlarRASLFRFFRRPLAWSLLALALLSAMTAVSGFGLSKLYLVDAGWPLE 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 582006829 252 QIGLLMSVAGASVGLLAAVAaarllqrqrAATLLLRAGWLRSLAY---LAVAGLLLSGLADGSPLWLG---AMVLVLLA- 324
Cdd:TIGR02718 244 WIGRLGMAGGAVTVLLGCGG---------GAWLVRRAGLWRTFILgvgLAGSLALLWFAQAAFWLAPGiavAWSCSAFGs 314
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 582006829 325 -IRYLAMTSLYALFMQLCSRQ-QAGTDFTVLVCFELLVFFVGGSLSGFLAKGLGYETYYLLLGALSVLSVLL 394
Cdd:TIGR02718 315 lITGITSVAIYTAFMRFAGDGdQAGTDVTAVQSTRDLGELIASSIAGYLTDRFGYAGGFLSGTVLAVLAILL 386
|
|
| 2A0125 |
TIGR00901 |
AmpG-like permease; [Cellular processes, Adaptations to atypical conditions] |
27-353 |
7.00e-31 |
|
AmpG-like permease; [Cellular processes, Adaptations to atypical conditions]
Pssm-ID: 273329 [Multi-domain] Cd Length: 356 Bit Score: 121.34 E-value: 7.00e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 582006829 27 LPLYFFNVAMPAILRSQGVDLRWIGMLSLLYLPWAFKFLWAPLVDRHYLHSLGRRRTWLWLTQAALVAGILLLALTGLEH 106
Cdd:TIGR00901 2 LPLGLVGNTLPYWLRSKNVSLKTIGFFSLVGLPYSLKFLWSPLVDTVYLPFFGRRRSWLVLTQVLLLSLLLILSFLVPST 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 582006829 107 GLLLFVLVSLWISTFAATQDIAIDGYTVESLASDDHRLGSMAQSIGVALGSMFGGAGVLWLYQVVGWQSALLTLAG---- 182
Cdd:TIGR00901 82 DLPLLAGLAFLIAFFSATQDIALDAWRLEILSDEELGYGSTIYIVGYRAGMLLSGSLALVLASPEFANTGLITLWGyiff 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 582006829 183 LSALTMLA--------------VARVDDRLPAQAEAARPGFIATFKRPEIRWALLLILVYRLVEAPAMAMLTPMLVDRQW 248
Cdd:TIGR00901 162 WTALLILPgllvtlflakepqeDASVPKPLTQAVLKPIREFFQRKNMIQALLLLLLIVLYKLGDSAATVLTTLFLLDMGF 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 582006829 249 SLTQIGLLMSVAGASVGLLAAVAAARLLQRQRAATLLLRAGWLRSLAYLAVAGLLLSGLADGSP---LWLGAMVLVLLAI 325
Cdd:TIGR00901 242 SKEEIALVAKINGLLGAILGGLIGGIIMQPLNILYALLLFGIVQALTNAGFVWLASNGHHDGITfphLLMLFLTITLEAV 321
|
330 340
....*....|....*....|....*....
gi 582006829 326 R-YLAMTSLYALFMQLCSRQQAGTDFTVL 353
Cdd:TIGR00901 322 TgGLGTVAFVAFLSKLSNPKFGATQMALL 350
|
|
| ampG |
PRK11902 |
muropeptide transporter; Reviewed |
15-394 |
1.31e-28 |
|
muropeptide transporter; Reviewed
Pssm-ID: 183369 [Multi-domain] Cd Length: 402 Bit Score: 115.72 E-value: 1.31e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 582006829 15 LAVIVVLYLAHALPLYFFNVAMPAILRSQGVDLRWIGMLSLLYLPWAFKFLWAPLVDRHYLHSLGRRRTWLWLTQAALVA 94
Cdd:PRK11902 1 IGAMLLLGFASGLPLALTSGTLQAWMTVEGLDIQTIGFFSLVGQAYIFKFLWAPLMDRYTPPLLGRRRGWLLLTQVGLAA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 582006829 95 GILLLALTGLEHGLLLFVLVSLWISTFAATQDIAIDGYTVESLASDDHRLGSMAQSIGVALGSMFGGAGVLWLY-QVVGW 173
Cdd:PRK11902 81 SIAAMAFCPPHAALWPLAGLAVLVAFLSASQDIVFDAYSTDVLHPEERGAGAAVKVLGYRLAMLVSGGLALWLAdRVLGW 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 582006829 174 QSALLTLAGLSALTMLAV-----ARVDDRLPAQAEAARPG-FIATFKRPEIRWALLLILVYRLVEAPAMAMLTPMLV-DR 246
Cdd:PRK11902 161 GNTYLLMAGLMLAGALTTlwapePEVPARPPRSLGEAVVGpLRDFFSRRGAWALLLLIVLYKLGDAFAGSLSTTFLIrGA 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 582006829 247 QWSLTQIGLLMSVAGASVGLLAAVAaarllqrqrAATLLLRAGWLRSL----AYLAVAGLLLSGLADGSP-LWL-GAMVL 320
Cdd:PRK11902 241 GFSAGEVGIVNKTLGLAATIVGALA---------GGTLMVRLGLYRSLmlfgVLQAVSNLGYWVLAVTPKhLWTmALAIG 311
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 582006829 321 VLLAIRYLAMTSLYALFMQLCSRQQAGTDFTVLVCFELLVFFVGGSLSGFLAKGLGYETYYLLLGALSVLSVLL 394
Cdd:PRK11902 312 IENLCGGMGTAAFVALLMALCNRSFSATQYALLSALASVGRVYVGPTSGYLVEAYGWPGFYLMTVVIALPGLAL 385
|
|
| ampG |
PRK11010 |
muropeptide MFS transporter AmpG; |
16-244 |
7.87e-20 |
|
muropeptide MFS transporter AmpG;
Pssm-ID: 182898 [Multi-domain] Cd Length: 491 Bit Score: 91.24 E-value: 7.87e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 582006829 16 AVIVVLYLAHALPLYFFNVAMPAILRSQGVDLRWIGMLSLLYLPWAFKFLWAPLVDRHYLHSLGRRRTWLWLTQAALVAG 95
Cdd:PRK11010 15 AILLILGFASGLPLALTSGTLQAWMTVENIDLKTIGFFSLVGQAYVFKFLWSPLMDRYTPPFLGRRRGWLLATQLLLLVA 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 582006829 96 ILLLALTGLEHGLLLFVLVSLWISTFAATQDIAIDGYTVESLASDDHRLGSMAQSIGVALGSMFGGAGVLWLY-QVVGWQ 174
Cdd:PRK11010 95 IAAMGFLEPGTQLRWLAALAVVIAFCSASQDIVFDAWKTDVLPAEERGAGAAISVLGYRLAMLVSGGLALWLAdRYLGWQ 174
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 582006829 175 SALLTLAGLSAL----TMLAVARVDDRLPAQA--EAARPGFIATFKRPEIRWALLLILVYRLVEAPAMAMLTPMLV 244
Cdd:PRK11010 175 GMYWLMAALLIPciiaTLLAPEPTDTIPVPKTleQAVVAPLRDFFGRNNAWLILLLIVLYKLGDAFAMSLTTTFLI 250
|
|
| Acatn |
pfam13000 |
Acetyl-coenzyme A transporter 1; The mouse Acatn is a 61 kDa hydrophobic protein with six to ... |
18-156 |
3.56e-15 |
|
Acetyl-coenzyme A transporter 1; The mouse Acatn is a 61 kDa hydrophobic protein with six to 10 transmembrane domains. It appears to promote 9-O-acetylation in gangliosides.
Pssm-ID: 372424 [Multi-domain] Cd Length: 543 Bit Score: 77.02 E-value: 3.56e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 582006829 18 IVVLYLAHALPLYFFNVAMPAILRSQGVDLRW--IGMLSLLYLPWAFKFLWAPLVDRHYLHSLGRRRTWLWLTQaaLVAG 95
Cdd:pfam13000 4 LVALYFLQGIPVGLAFGTIPFLLKSMAKETSFtsLGIFSMATYPYSLKILWSPIVDSIYSKKIGRRRSWIIPVQ--LVSG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 582006829 96 ILLLAL----------TGLE---HGLLLFVLVSLWISTFA----------ATQDIAIDGYTVESLASDDHRLGSMAQSIG 152
Cdd:pfam13000 82 IMLIILgyciskglifPGVDdafHGRLSKGVLNVNITTLTwyfgilvflcATQDIAVDGWALTILSKQSLSYASTAQTVG 161
|
....
gi 582006829 153 VALG 156
Cdd:pfam13000 162 LNTG 165
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
11-348 |
3.17e-09 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 58.06 E-value: 3.17e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 582006829 11 TRLALAVIVVLYLAHALPLYFFNVAMPAILRSQGVDLRWIGMLSLLY-LPWA-FKFLWAPLVDRhylhsLGRRRTWLWlt 88
Cdd:COG2814 8 RWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYlLGAAlGAPLAGRLADR-----FGRRRVLLL-- 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 582006829 89 qaALVAGILLLALTGLEHGLLLFVLVSLWISTFAATQDIAIDGYTVESLASDDHRLGSMAQSIGVALGSMFGGAGVLWLY 168
Cdd:COG2814 81 --GLLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 582006829 169 QVVGWQSALLTLAGLSALTMLAVAR-VDDRLPAQAEAARPGFIATFKRPEIRWALLLILVYRLVEAPAMAMLTPMLVDR- 246
Cdd:COG2814 159 DLFGWRWVFLVNAVLALLALLLLLRlLPESRPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVl 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 582006829 247 QWSLTQIGLLMSVAGASVGLLAAVAAARLLQRQRAATLLLRAGwlrslayLAVAGLLLSGLADGSPLWLGAMVLVLLAIr 326
Cdd:COG2814 239 GLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLL-------LLALGLLLLALAGSLWLLLLALFLLGFGF- 310
|
330 340
....*....|....*....|..
gi 582006829 327 YLAMTSLYALFMQLCSRQQAGT 348
Cdd:COG2814 311 GLLFPLLQALVAELAPPEARGR 332
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
18-395 |
2.57e-08 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 55.51 E-value: 2.57e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 582006829 18 IVVLYLAHALPLYFFNVAMPAILRSQGVDLRWIGMLSLLYL--PWAFKFLWAPLVDRHylhslgRRRTWLWLTQAALVAG 95
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSlgYALLQPLAGLLADRF------GRRPVLLLGLLLFALG 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 582006829 96 ILLLAL-TGLEHGLLLFVLVSLWISTFAATQDIAIDGYTVESLASDDHRLGSMAQSIGVALGSMFGGAGVLWLYqvVGWQ 174
Cdd:cd06174 75 ALLFAFaPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLG--FGWR 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 582006829 175 SALLTLAGLSALTMLAVARVDDRLPAQAEAARP---------GFIATFKRPEIRWALLLILVYRLVEAPAMAMLTPMLVD 245
Cdd:cd06174 153 AVFLIAAALALLAAILLLLVVPDPPESARAKNEeassksvlkLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLD 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 582006829 246 RQWSLTQIGLLMSVAGASVGLLAAVAAARLLQRQRAATLLLRAGwlrslaYLAVAGLLLSGLADGSPLWLGAMVLVLLAI 325
Cdd:cd06174 233 LGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIG------LLLMALGLALLLLAPSLLLLLLLLLLLGFG 306
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 582006829 326 RYLAMTSLYALFMQLCSRQQAGTDFTVLVCFELLVFFVGGSLSGFLAKG-LGYETYYLLLGALSVLSVLLC 395
Cdd:cd06174 307 LGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAAtFGLTGAFLVLAVLLLLAAILL 377
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
18-364 |
4.54e-08 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 54.35 E-value: 4.54e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 582006829 18 IVVLYLAHALPLYFFNVAMPAILRSQ-GVDLRWIGMLSLLYL--PWAFKFLWAPLVDRHylhslGRRRTWLWLTQAALVA 94
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDlGISPTEIGLLLTLFSlgYALAQPLAGRLSDRF-----GRRRVLLIGLLLFALG 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 582006829 95 GILLLALTGLEHGLLLFVLVSLWISTFAAtqdiAIDGYTVESLASDDHRLGSMAQSIGVALGSMFGGAGVLWLYQVVGWQ 174
Cdd:pfam07690 76 LLLLLFASSLWLLLVLRVLQGLGAGALFP----AALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWR 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 582006829 175 SALLTLAGLSALTMLAVARVDDRLPAQAEAARPGFIAT-------FKRPEIRWALLLILVYRLVEAPAMAMLTPMLVDRQ 247
Cdd:pfam07690 152 AAFLILAILSLLAAVLLLLPRPPPESKRPKPAEEARLSlivawkaLLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLG 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 582006829 248 WSLTQIGLLMSVAGASVGLLAAVAAARLLQRQRAATLLLRAGwlrsLAYLAVAGLLLSGLADGSPLWLGAMVLVLLAIrY 327
Cdd:pfam07690 232 LSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALL----LLILAALGLLLLSLTLSSLWLLLALLLLGFGF-G 306
|
330 340 350
....*....|....*....|....*....|....*..
gi 582006829 328 LAMTSLYALFMQLCSRQQAGTDFTVLVCFELLVFFVG 364
Cdd:pfam07690 307 LVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALG 343
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
13-320 |
9.63e-08 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 53.72 E-value: 9.63e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 582006829 13 LALAVIVVLYLAHALPLYFFNVAMPAILRSQGVDLRWIGML-SLLYLPWAFKFLWAPLVDRHylhsLGRRRTwLWLTQAA 91
Cdd:COG2807 18 LLLLAIVLVALNLRPAITSVGPLLPEIRADLGLSATQAGLLtTLPLLAFGLFAPLAPRLARR----FGLERT-LLLALLL 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 582006829 92 LVAGILLLALTGlehglllfVLVSLWISTFAATQDIAIDGYTVESLASDD--HRLGSM--AQSIGVALGSMFGGAGVLWL 167
Cdd:COG2807 93 LAAGLLLRSLAP--------SVALLLAGTALIGAGIAVGNVLLPGLIKRWfpDRVGLMtgLYTAAMGLGAALAAGLTVPL 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 582006829 168 YQVVGWQSALLTLAGLSALTMLAVARVDDRLPAQAEAARPG--FIATFKRPEIRWALLLILVYRLVEAPAMAMLTPMLVD 245
Cdd:COG2807 165 AAALGWRGALAVWALLALLALLLWLPLLRRRPAAAAAAPAAasLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILRD 244
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 582006829 246 RQWSLTQIGLLMSVAGAsVGLLAAVAAARLLQRQRAatlllRAGWLRSLAYLAVAGLLLSGLADGSPLWLGAMVL 320
Cdd:COG2807 245 AGLSAATAGLLLSLFQL-AGIPGSLLVPLLADRLGD-----RRPLLLLLGLLGLAGLLGLLLAPGSLPWLWAVLL 313
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
31-394 |
1.96e-06 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 49.54 E-value: 1.96e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 582006829 31 FFNVAMPAILRSQGVDLRWIGMLSLLY-LPWAFKFLWA-PLVDRHylhslGRRRTWLW--LTQAALVAGILLLALTGLEH 106
Cdd:cd06173 17 IFTVALPWLVLQLTGSALLVGLVLAAFfLPFLLFSPFAgVLADRF-----DRRRLLILadLLRALLAAVLALLALLGSLS 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 582006829 107 GLLLFVLVSLwISTFAATQDIAIDGYTVESLASDDH----RLGSMAQSIGVALGSMFGGAgvlwLYQVVGWQSALLTLAG 182
Cdd:cd06173 92 LWLLLVLAFL-LGIASAFFGPARQALLPELVPKEQLvranALNSLATQLARIIGPALGGL----LVALLGPGGAFAINAL 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 582006829 183 LSALTMLAVARVDDRLPAQAEAARP--------GFIATFKRPEIRWALLLILVYRLVEAPAMAMLtPMLVDRQWSLTQIG 254
Cdd:cd06173 167 SFLLSALLLLFIRRPPPAAPGESSSlllrdlreGLRYLRRSPLLRLLLLALALFALLGGALTVLL-PLLAKEVLGGGAAG 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 582006829 255 LLMSVAGASVGLLAAVAAARLLQRQRAATLLLRAGwlrslayLAVAGLLLSGLADGSPLWLGAMVLVLLAIRY-LAMTSL 333
Cdd:cd06173 246 YGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIG-------ALLLGLALLVLGLSPSLWLLLAALFLLGLAGgLFNVPL 318
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 582006829 334 YALFMQLCSRQQAGTDFTVLVCFELLVFFVGGSLSGFLAKGLGYETYYLLLGALSVLSVLL 394
Cdd:cd06173 319 NTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALL 379
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
12-400 |
5.62e-06 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 47.94 E-value: 5.62e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 582006829 12 RLALAVIVVLYLAHALPLYFFNVAMPAILRSQGVDLRWIGML-SLLYLPWA-FKFLWAPLVDRhylhsLGRRRTWLWltq 89
Cdd:COG2271 9 WRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLaSAFFLGYAlGQIPAGLLADR-----FGRRRVLAI--- 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 582006829 90 aALVAGILLLALTGLEHGLLLFVLVSLWISTFAATQDIAIDGYTVESLASDDHRLGSMAQSIGVALGSMFGGAGVLWLYQ 169
Cdd:COG2271 81 -GLLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 582006829 170 VVGWQSALLTLAGLSALtmLAVARVddrlpaqaeaarpgfiatfkrpeirwaLLLILVYRLVEAPAMAMLT---PMLVD- 245
Cdd:COG2271 160 AFGWRAAFLILGLPGLL--LALLRF---------------------------WLLALAYFLVYFALYGFLTwlpTYLVEv 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 582006829 246 RQWSLTQIGLLMSVAGASVGLLAAVAAARLLQRQRAATLLLRAGWLrslayLAVAGLLLSGLADGSPLWLGAMVLVLLAI 325
Cdd:COG2271 211 RGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLL-----LAALALLLLALLPSPALAIALLFLAGFGL 285
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 582006829 326 rYLAMTSLYALFMQLCSRQQAGTDFTVLVCFELLVFFVGGSLSGFLAKGLGYETYYLLLGALSVLSVLLCKPIVR 400
Cdd:COG2271 286 -GGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLLR 359
|
|
| MFS_MFSD6 |
cd17335 |
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ... |
36-263 |
1.07e-05 |
|
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 47.19 E-value: 1.07e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 582006829 36 MPAILRSQGVDLRWIGMLSLL--YLPWAFKFLWAPLVDRhylhsLGRRRTWLWLtqAALVAGILLLALTGLEHGLLLFVL 113
Cdd:cd17335 20 LSVYLKQLGLSPTQIGILIGIrpFVRFLSAPLWGALADR-----FGKRKALLLL--SLLAAVLFFLSLFFVAQIFWLLLL 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 582006829 114 VSLWISTFAATQDIAIDGYTVESLASDDHRLGS--MAQSIGVALGSMFGGAGVLWLYQVVGWQSALLTLAGLSALTMLAV 191
Cdd:cd17335 93 LVILGAFFSAPVVPLVDSITLQYLGEERERYGKqrLWGSIGFGIAALLVGILIDRSSTYKNYTIAFYVFAVLMLLALLLA 172
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 582006829 192 ARVDDRLPAQAEAAR-PGFIATFKRPEIRWALLLILVYRLVEAPAMAMLTPMLVDRQWSLTQIGLLMSVAGAS 263
Cdd:cd17335 173 LKFPFRPKHPEPNENtGGLLALLRNPRVLAFLLVAFLMGFGHGLIYSFLFWHLQDLGGSKTLIGLLWTVGVVS 245
|
|
| MFS_FBT |
cd17484 |
Folate-biopterin transporter of the Major Facilitator Superfamily of transporters; The ... |
53-376 |
1.28e-04 |
|
Folate-biopterin transporter of the Major Facilitator Superfamily of transporters; The Folate-biopterin transporter (FBT) family includes folate carriers related to those of trypanosomatids in higher plant plastids and cyanobacteria. FBT mediates folate monoglutamate transport involved in tetrahydrofolate biosynthesis. It also mediates transport of antifolates, such as methotrexate and aminopterin. The FBT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341037 [Multi-domain] Cd Length: 399 Bit Score: 43.75 E-value: 1.28e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 582006829 53 LSLLYLPWAFKFLWAPLVDRHYLhsLG-RRRTWLWLTQAALVAGILLLALTGLEHGLLLFVLVSLWiSTFAATQDIAIDG 131
Cdd:cd17484 39 TSIASLPWAIKPLYGLLSDSVPI--FGyRRKPYLILAGALGALSWLALALVSNSSLALALLLLLLA-SLGVAFSDVVIDA 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 582006829 132 YTVE-------SLASDDHRLGSMAQSIGVALGSMFGGAGVLWL--YQVVGWQSALLTLAGLSALTMLAVARVDDRLPAQA 202
Cdd:cd17484 116 LVVEasrgapqSLAGDLQSLCWGSSAIGGIVGSYFSGYLLELLgpRTVFAVTSFFPLLLLIVAFFVKEERVPPHRTKENF 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 582006829 203 EAARPGFIATFKRPEIRWALLLILVYRLVEAPAMAMLTPMLVDRQWSLTQIGLLMSVAGASvgllaaVAAARLLQRQRAA 282
Cdd:cd17484 196 DEQLKALWETVKQPSIWLPALFIFLYQATPSSGSAMFYFMTNELGFSPEFLGRLRVIGSIA------SLLGVLLYNRFLK 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 582006829 283 TLLLRAGWLRSLAYLAVAGLLLSGLADGSPLWLG----AMVL----VLLAIRYLAMTSLYALFMQLCSRQQAGTDFTVLV 354
Cdd:cd17484 270 HVPFRKIFFWTTVLLVLLGLTDLILVTRWNLKLGipdhAFVLgddaVVTVIGEILFMPILVLAARLCPPGIEGTVFALLM 349
|
330 340
....*....|....*....|..
gi 582006829 355 CFELLVFFVGGSLSGFLAKGLG 376
Cdd:cd17484 350 SISNLGSLTSSFLGALLTKALG 371
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
11-394 |
2.93e-04 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 42.53 E-value: 2.93e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 582006829 11 TRLALAVIVVLYLAHALPLYFFNVAMPAILRSQGVDLRWIGML-SLLYLPWAFKFLWAPLVdrhyLHSLGRRRTwlwlTQ 89
Cdd:COG0738 6 YRRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLlFAFFLGYLLASLPAGRL----IDRFGYKRG----LL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 582006829 90 AALVAGILLLALTGLEHGLLLFVLVSLWISTFAATQDIAIDGYTVESLASDDHRLGSMAQ---SIGVALGSMFGGAgVLW 166
Cdd:COG0738 78 LGLLLMALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGPETAASRLNLLHaffSLGALLGPLLGGL-LIL 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 582006829 167 LYQVVGWQSALLTLAGLSALTMLAVARV----DDRLPAQAEAARPGFIATFKRPEIRWALLLILVYRLVEAPAMAMLTPM 242
Cdd:COG0738 157 LGLSLSWHLPYLILAVLLLLLALLFLRSklpeIEEEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLY 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 582006829 243 LVD-RQWSLTQIGLLMSV--AGASVGLLAAVAAARLLQRQRAatlllragwLRSLAYLAVAGLLLSGLADGSPLWLGAMV 319
Cdd:COG0738 237 LKDvLGLSEATAALGLSLfwGGMTIGRFLGGFLLKRFGPVRL---------LRLSALLAAVGLLLALLAPGPWLALIGLA 307
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 582006829 320 LVllairYLAMTSLYALFMQLCSRQ---QAGTDFTVLVCFELLVFFVGGSLSGFLAKGLGYETYYLLLGALSVLSVLL 394
Cdd:COG0738 308 LV-----GLGLSLMFPTIFSLALDGlgkRTAAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVPLVCYLLILLL 380
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
146-394 |
3.64e-04 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 42.56 E-value: 3.64e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 582006829 146 SMAQSIGVALGSMFGGagvlWLYQVVGWQSALLTLAGLSALTMLAVARVDDRLPAQAEAA-------RPGFIATFKRPEI 218
Cdd:cd17325 126 SSAIGLGFLIGPLLGG----LLADALGYRAPFLVCAALALLALVLALLLLPEPRPPPNKRavsaarlRSGLRLLLRDRRL 201
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 582006829 219 RWALLLILVYRLVEAPAMAMLTPMLVDRQ-WSLTQIGLLMSVAGASVGLLAAVAAARLLQRQRaaTLLLRAGWLrslayL 297
Cdd:cd17325 202 LALFLAIFVLAFAFGALEPFLPLYAAELGgLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGR--KPLILIGLL-----L 274
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 582006829 298 AVAGLLLSGLADGSPLWLGAMVLVLLAIRyLAMTSLYALFMQLCSRQQAGTDFTVLVCFELLVFFVGGSLSGFLAKGLGY 377
Cdd:cd17325 275 SAVALLLLPLATSFWLLLLLLALLGLGLG-LVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGF 353
|
250
....*....|....*..
gi 582006829 378 ETYYLLLGALSVLSVLL 394
Cdd:cd17325 354 ATPFLAAAALLLLAAVL 370
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
44-377 |
9.26e-03 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 37.96 E-value: 9.26e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 582006829 44 GVDLRWIGMLSLLYLPWA--FKFLWAPLVDRHYLHsLGRRRTWLWLtqAALVAGILLLAL----TGLEHGLLLFVLVSLW 117
Cdd:COG2211 42 GLSAALVGLILLVARLWDaiTDPLIGALSDRTRTR-WGRRRPWILI--GAIPLALSFVLLftapDLSPTGKLIYALVTYL 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 582006829 118 ISTFAAT-QDIAIDGYTVESLASDDHRL-GSMAQSIGVALGSMFGGAGVLWLYQVV------GWQSALLTLAGLSALTML 189
Cdd:COG2211 119 LLGLAYTlVNIPYSALGAELTPDYEERTrLSSWRFAFAGLGGLLASVLPPPLVAAFggdaalGYRLTALIFAVLGLLAFL 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 582006829 190 AVAR-VDDRLPAQAEAA--RPGFIATFKRPEIRWALLLILVYRLVEAPAMAMLTPMLVDR-QWSLTQIGLLMSVAGASVG 265
Cdd:COG2211 199 LTFFgTKERPVPEEEKVslKESLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVlGLSAALVGLLLALYFLAAL 278
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 582006829 266 LLAAVAAARLLQRQRAATLLLRAGwlrslayLAVAGLLLSGLADGSPLWLGAMVLVLLAIRY-LAMTSLYALFMQLC--- 341
Cdd:COG2211 279 LGAPLWPRLAKRFGKKKAFIIGLL-------LAALGLLLLFFLGPGNLWLLLVLAALAGIGLgAILVLPWAMLADVVdyd 351
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 582006829 342 ----SRQQAGTDFTVLVCFELLVFFVGGSLSGFLAKGLGY 377
Cdd:COG2211 352 ewktGRRREGLYFGIFTFAIKLGQALAGALAGLLLALFGY 391
|
|
| |
