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Conserved domains on  [gi|646227150|emb|CDR32800|]
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TLC domain-containing protein [Caenorhabditis elegans]

Protein Classification

TLC domain-containing protein( domain architecture ID 10653905)

TLC (TRAM, LAG1 and CLN8) domain-containing protein may possess one of multiple functions such as lipid trafficking, metabolism, or sensing

PubMed:  12151215

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
TLC smart00724
TRAM, LAG1 and CLN8 homology domains; Protein domain with at least 5 transmembrane ...
85-285 5.11e-30

TRAM, LAG1 and CLN8 homology domains; Protein domain with at least 5 transmembrane alpha-helices. Lag1p and Lac1p are essential for acyl-CoA-dependent ceramide synthesis, TRAM is a subunit of the translocon and the CLN8 gene is mutated in Northern epilepsy syndrome. The family may possess multiple functions such as lipid trafficking, metabolism, or sensing. Trh homologues possess additional homeobox domains.


:

Pssm-ID: 214789  Cd Length: 205  Bit Score: 113.16  E-value: 5.11e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 646227150    85 KRKRLLNLTTSLIHSTISGLYLFAFFCYNTKLMFAAPLHYYTYLDSQIITLSIGYFFYDGIDLVMNDKLSISTG-VLLFH 163
Cdd:smart00724   2 KFNESSNRLVSYLHSVIAGLYALYSEPWLSDPKSLYPIQGMSPLAKFYYLFSLGYFIHDLVALLLFQDLKRKDFkEMLVH 81
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 646227150   164 HVASIYVLSTAVLSKKFLLYAYWAMLMEVSSIFLHTRSILHISKLSTTSMIgfsKVVSYLNLITFIVFRGFVQFFLFGWA 243
Cdd:smart00724  82 HIATLLLISLSYVLNFTRLGLLLLLLHELSDPFLHLRKLLNYAGRKKSLLY---DVNFVLFAVVFFVFRLILFPFLILTV 158
                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*..
gi 646227150   244 WVNYDHIH-----FIFKCIAFGGGFCFAVINVSLLLRILHSDGFLLS 285
Cdd:smart00724 159 TVHYAQAEsglfpPLLYLLFLLLLLCLQLLNIYWFFLILRMARKLLS 205
 
Name Accession Description Interval E-value
TLC smart00724
TRAM, LAG1 and CLN8 homology domains; Protein domain with at least 5 transmembrane ...
85-285 5.11e-30

TRAM, LAG1 and CLN8 homology domains; Protein domain with at least 5 transmembrane alpha-helices. Lag1p and Lac1p are essential for acyl-CoA-dependent ceramide synthesis, TRAM is a subunit of the translocon and the CLN8 gene is mutated in Northern epilepsy syndrome. The family may possess multiple functions such as lipid trafficking, metabolism, or sensing. Trh homologues possess additional homeobox domains.


Pssm-ID: 214789  Cd Length: 205  Bit Score: 113.16  E-value: 5.11e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 646227150    85 KRKRLLNLTTSLIHSTISGLYLFAFFCYNTKLMFAAPLHYYTYLDSQIITLSIGYFFYDGIDLVMNDKLSISTG-VLLFH 163
Cdd:smart00724   2 KFNESSNRLVSYLHSVIAGLYALYSEPWLSDPKSLYPIQGMSPLAKFYYLFSLGYFIHDLVALLLFQDLKRKDFkEMLVH 81
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 646227150   164 HVASIYVLSTAVLSKKFLLYAYWAMLMEVSSIFLHTRSILHISKLSTTSMIgfsKVVSYLNLITFIVFRGFVQFFLFGWA 243
Cdd:smart00724  82 HIATLLLISLSYVLNFTRLGLLLLLLHELSDPFLHLRKLLNYAGRKKSLLY---DVNFVLFAVVFFVFRLILFPFLILTV 158
                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*..
gi 646227150   244 WVNYDHIH-----FIFKCIAFGGGFCFAVINVSLLLRILHSDGFLLS 285
Cdd:smart00724 159 TVHYAQAEsglfpPLLYLLFLLLLLCLQLLNIYWFFLILRMARKLLS 205
TRAM_LAG1_CLN8 pfam03798
TLC domain;
95-277 2.12e-17

TLC domain;


Pssm-ID: 461055  Cd Length: 200  Bit Score: 78.86  E-value: 2.12e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 646227150   95 SLIHSTISGLYLFAFFCYNTKLMFAA---------PLHYYTYLDSQIITLSIGYFFYDGIDLVMNDKLSISTGVLLFHHV 165
Cdd:pfam03798   8 SLVYYLVSTILGLYVLSSEPWFWNPTelwydypnrVLGYTSWLVKFYYLIQLGYFIWDLLVLLFYEKRRKDFWEMLLHHV 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 646227150  166 ASIYVLSTAVLSKKFLLYAYWAMLMEVSSIFLHTRSILHISKLSTTSMIGFskvvsYLNLITFIVFRGFVQFFLFGWAWV 245
Cdd:pfam03798  88 ITLVLIVLSYFRNFTRVGLLVLLLHELSDPFLNLAKILNYLGKGTSCDVLF-----VLFLVSFFVTRLVLGPFWILLSIL 162
                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 646227150  246 NYDHIH-----FIFKCIAFGGGFCFAVINVSLLLRIL 277
Cdd:pfam03798 163 DYAGLDvptgpFLLYYIFLILLLVLQLLNIYWFYLII 199
 
Name Accession Description Interval E-value
TLC smart00724
TRAM, LAG1 and CLN8 homology domains; Protein domain with at least 5 transmembrane ...
85-285 5.11e-30

TRAM, LAG1 and CLN8 homology domains; Protein domain with at least 5 transmembrane alpha-helices. Lag1p and Lac1p are essential for acyl-CoA-dependent ceramide synthesis, TRAM is a subunit of the translocon and the CLN8 gene is mutated in Northern epilepsy syndrome. The family may possess multiple functions such as lipid trafficking, metabolism, or sensing. Trh homologues possess additional homeobox domains.


Pssm-ID: 214789  Cd Length: 205  Bit Score: 113.16  E-value: 5.11e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 646227150    85 KRKRLLNLTTSLIHSTISGLYLFAFFCYNTKLMFAAPLHYYTYLDSQIITLSIGYFFYDGIDLVMNDKLSISTG-VLLFH 163
Cdd:smart00724   2 KFNESSNRLVSYLHSVIAGLYALYSEPWLSDPKSLYPIQGMSPLAKFYYLFSLGYFIHDLVALLLFQDLKRKDFkEMLVH 81
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 646227150   164 HVASIYVLSTAVLSKKFLLYAYWAMLMEVSSIFLHTRSILHISKLSTTSMIgfsKVVSYLNLITFIVFRGFVQFFLFGWA 243
Cdd:smart00724  82 HIATLLLISLSYVLNFTRLGLLLLLLHELSDPFLHLRKLLNYAGRKKSLLY---DVNFVLFAVVFFVFRLILFPFLILTV 158
                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*..
gi 646227150   244 WVNYDHIH-----FIFKCIAFGGGFCFAVINVSLLLRILHSDGFLLS 285
Cdd:smart00724 159 TVHYAQAEsglfpPLLYLLFLLLLLCLQLLNIYWFFLILRMARKLLS 205
TRAM_LAG1_CLN8 pfam03798
TLC domain;
95-277 2.12e-17

TLC domain;


Pssm-ID: 461055  Cd Length: 200  Bit Score: 78.86  E-value: 2.12e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 646227150   95 SLIHSTISGLYLFAFFCYNTKLMFAA---------PLHYYTYLDSQIITLSIGYFFYDGIDLVMNDKLSISTGVLLFHHV 165
Cdd:pfam03798   8 SLVYYLVSTILGLYVLSSEPWFWNPTelwydypnrVLGYTSWLVKFYYLIQLGYFIWDLLVLLFYEKRRKDFWEMLLHHV 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 646227150  166 ASIYVLSTAVLSKKFLLYAYWAMLMEVSSIFLHTRSILHISKLSTTSMIGFskvvsYLNLITFIVFRGFVQFFLFGWAWV 245
Cdd:pfam03798  88 ITLVLIVLSYFRNFTRVGLLVLLLHELSDPFLNLAKILNYLGKGTSCDVLF-----VLFLVSFFVTRLVLGPFWILLSIL 162
                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 646227150  246 NYDHIH-----FIFKCIAFGGGFCFAVINVSLLLRIL 277
Cdd:pfam03798 163 DYAGLDvptgpFLLYYIFLILLLVLQLLNIYWFYLII 199
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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