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Conserved domains on  [gi|857867693|emb|CDT47279|]
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phosphatidylglycerophosphatase A [Vibrio coralliirubri]

Protein Classification

phosphatidylglycerophosphatase A( domain architecture ID 10793528)

phosphatidylglycerophosphatase A catalyzes formation of phosphatidylglycerol from phosphatidylglycerophosphate

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PRK11068 PRK11068
phosphatidylglycerophosphatase A; Provisional
2-167 4.67e-90

phosphatidylglycerophosphatase A; Provisional


:

Pssm-ID: 182942  Cd Length: 164  Bit Score: 259.61  E-value: 4.67e-90
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 857867693   2 MTNPLSLISLKNPWHFLATGFGSGLSPIIPGTMGTLASIPLYLLLVQLPFPAYVAVVVVSCIIGIKICQVTSDDMGVHDH 81
Cdd:PRK11068   1 MDVAKSRLKLSNPWHLLATGFGSGLSPIVPGTMGSLAAIPFWYLLTFLPWQLYSLVVMLGICIGVYLCHQTAKDMGVHDH 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 857867693  82 GSIVWDEFAGFWITmslvpMLNIPADDWKWLLTGFVLFRFFDMVKPWPIGWLDARIHGGLGIMIDDIVAGIMAAISLYAV 161
Cdd:PRK11068  81 GSIVWDEFIGMWIT-----LMALPVNDWQWVAAGFVIFRILDMWKPWPIRWFDRNVHGGMGIMIDDIVAGVISAGILYFI 155

                 ....*.
gi 857867693 162 AHFAGW 167
Cdd:PRK11068 156 GHHWPL 161
 
Name Accession Description Interval E-value
PRK11068 PRK11068
phosphatidylglycerophosphatase A; Provisional
2-167 4.67e-90

phosphatidylglycerophosphatase A; Provisional


Pssm-ID: 182942  Cd Length: 164  Bit Score: 259.61  E-value: 4.67e-90
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 857867693   2 MTNPLSLISLKNPWHFLATGFGSGLSPIIPGTMGTLASIPLYLLLVQLPFPAYVAVVVVSCIIGIKICQVTSDDMGVHDH 81
Cdd:PRK11068   1 MDVAKSRLKLSNPWHLLATGFGSGLSPIVPGTMGSLAAIPFWYLLTFLPWQLYSLVVMLGICIGVYLCHQTAKDMGVHDH 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 857867693  82 GSIVWDEFAGFWITmslvpMLNIPADDWKWLLTGFVLFRFFDMVKPWPIGWLDARIHGGLGIMIDDIVAGIMAAISLYAV 161
Cdd:PRK11068  81 GSIVWDEFIGMWIT-----LMALPVNDWQWVAAGFVIFRILDMWKPWPIRWFDRNVHGGMGIMIDDIVAGVISAGILYFI 155

                 ....*.
gi 857867693 162 AHFAGW 167
Cdd:PRK11068 156 GHHWPL 161
PgpA COG1267
Phosphatidylglycerophosphatase A [Lipid transport and metabolism]; ...
11-164 1.15e-69

Phosphatidylglycerophosphatase A [Lipid transport and metabolism]; Phosphatidylglycerophosphatase A is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 440878  Cd Length: 148  Bit Score: 207.26  E-value: 1.15e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 857867693  11 LKNPWHFLATGFGSGLSPIIPGTMGTLASIPLYLLLVQLPFPAYVAVVVVSCIIGIKICQVTSDDMGVHDHGSIVWDEFA 90
Cdd:COG1267    1 LRNPAHLLATGFGSGLSPKAPGTWGSLAALPLYLLLLGLGLWLLLLLLLLLFLIGIWACGKTERDLGVHDPGEIVIDEVV 80
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 857867693  91 GFWITMSLVPMlnipadDWKWLLTGFVLFRFFDMVKPWPIGWLDARIHGGLGIMIDDIVAGIMAAISLYAVAHF 164
Cdd:COG1267   81 GMWITLLFLPA------GWLWLLAAFVLFRLFDILKPWPIRWLDRRLKGGLGIMLDDVLAGIYALLVLALLAWL 148
PgpA cd06971
Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid ...
15-161 7.02e-57

Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Phosphatidylglycerophosphatase A domain represents a family of bacterial membrane-associated enzymes involved in lipid metabolism. The prototype of this CD is a putative Phosphatidylglycerophosphatase A (PGPase A) from Listeria monocytogenes. PGPase A (EC: 3.1.3.27), encoded by the gene pgpA, specifically catalyzes the formation of phosphatidylglycerol from phosphatidyl glycerophosphate (PGP). It requires Mg2+ for activity and is inhibited by sulfhydryl agents and freezing/thawing. PGPase B encoded from pgpB is not included in this family, which also acts on phosphatidic acid (PA) and lysophosphatidic acid (LPA). Aside from PGPase A and B, evidence shows that there is another PGPase existing in E. coli. Thus, PGPase A is not essential for PGPase activity in E. coli.


Pssm-ID: 133477  Cd Length: 143  Bit Score: 175.03  E-value: 7.02e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 857867693  15 WHFLATGFGSGLSPIIPGTMGTLASIPLYLLLVQLPFPAY-VAVVVVSCIIGIKICQVTSDDMGVHDHGSIVWDEFAGFW 93
Cdd:cd06971    1 AHFLATGFGSGLSPIAPGTFGSLAALPLELLLSELGKVLLeLLALLLAFLLGIWAAEKTLKDLGVHDPGEIVIDEVVGQW 80
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 857867693  94 ITMSLVPMLnipaddWKWLLTGFVLFRFFDMVKPWPIGWLDARIHGGLGIMIDDIVAGIMAAISLYAV 161
Cdd:cd06971   81 IALLIVPFG------WLWGLLAFLLFRFFDIVKPGPIGWLDRKVKGGLGVMLDDILAGLYAALVLRLL 142
PgpA pfam04608
Phosphatidylglycerophosphatase A; This family represents a family of bacterial ...
17-162 6.80e-38

Phosphatidylglycerophosphatase A; This family represents a family of bacterial phosphatidylglycerophosphatases (EC:3.1.3.27), known as PgpA. It appears that bacteria possess several phosphatidylglycerophosphatases, and thus, PgpA is not essential in Escherichia coli.


Pssm-ID: 461365  Cd Length: 136  Bit Score: 126.55  E-value: 6.80e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 857867693   17 FLATGFGSGLSPIIPGTMGTLASIPLYLLLVQ---LPFPAYVAVVVVSCIIGIKICQVTSDDMGVHDHGSIVWDEFAGFW 93
Cdd:pfam04608   1 LIATLFGLGLLPFAPGTWGSLAALPLALLLVLskpLSLILLLVALLLLFLLGIYAADKAEKDLGKKDPGEIVIDEVLGQL 80
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 857867693   94 ITMSLVpmlnipaddwkwLLTGFVLFRFFDMVKPWPIGWLDaRIHGGLGIMIDDIVAGIMAAISLYAVA 162
Cdd:pfam04608  81 IALLFL------------LLAGFVLFRFFDILKPWPISKLD-RLPGGWGVMLDDILAGLYAALLLLLLH 136
 
Name Accession Description Interval E-value
PRK11068 PRK11068
phosphatidylglycerophosphatase A; Provisional
2-167 4.67e-90

phosphatidylglycerophosphatase A; Provisional


Pssm-ID: 182942  Cd Length: 164  Bit Score: 259.61  E-value: 4.67e-90
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 857867693   2 MTNPLSLISLKNPWHFLATGFGSGLSPIIPGTMGTLASIPLYLLLVQLPFPAYVAVVVVSCIIGIKICQVTSDDMGVHDH 81
Cdd:PRK11068   1 MDVAKSRLKLSNPWHLLATGFGSGLSPIVPGTMGSLAAIPFWYLLTFLPWQLYSLVVMLGICIGVYLCHQTAKDMGVHDH 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 857867693  82 GSIVWDEFAGFWITmslvpMLNIPADDWKWLLTGFVLFRFFDMVKPWPIGWLDARIHGGLGIMIDDIVAGIMAAISLYAV 161
Cdd:PRK11068  81 GSIVWDEFIGMWIT-----LMALPVNDWQWVAAGFVIFRILDMWKPWPIRWFDRNVHGGMGIMIDDIVAGVISAGILYFI 155

                 ....*.
gi 857867693 162 AHFAGW 167
Cdd:PRK11068 156 GHHWPL 161
PgpA COG1267
Phosphatidylglycerophosphatase A [Lipid transport and metabolism]; ...
11-164 1.15e-69

Phosphatidylglycerophosphatase A [Lipid transport and metabolism]; Phosphatidylglycerophosphatase A is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 440878  Cd Length: 148  Bit Score: 207.26  E-value: 1.15e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 857867693  11 LKNPWHFLATGFGSGLSPIIPGTMGTLASIPLYLLLVQLPFPAYVAVVVVSCIIGIKICQVTSDDMGVHDHGSIVWDEFA 90
Cdd:COG1267    1 LRNPAHLLATGFGSGLSPKAPGTWGSLAALPLYLLLLGLGLWLLLLLLLLLFLIGIWACGKTERDLGVHDPGEIVIDEVV 80
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 857867693  91 GFWITMSLVPMlnipadDWKWLLTGFVLFRFFDMVKPWPIGWLDARIHGGLGIMIDDIVAGIMAAISLYAVAHF 164
Cdd:COG1267   81 GMWITLLFLPA------GWLWLLAAFVLFRLFDILKPWPIRWLDRRLKGGLGIMLDDVLAGIYALLVLALLAWL 148
PgpA cd06971
Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid ...
15-161 7.02e-57

Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Phosphatidylglycerophosphatase A domain represents a family of bacterial membrane-associated enzymes involved in lipid metabolism. The prototype of this CD is a putative Phosphatidylglycerophosphatase A (PGPase A) from Listeria monocytogenes. PGPase A (EC: 3.1.3.27), encoded by the gene pgpA, specifically catalyzes the formation of phosphatidylglycerol from phosphatidyl glycerophosphate (PGP). It requires Mg2+ for activity and is inhibited by sulfhydryl agents and freezing/thawing. PGPase B encoded from pgpB is not included in this family, which also acts on phosphatidic acid (PA) and lysophosphatidic acid (LPA). Aside from PGPase A and B, evidence shows that there is another PGPase existing in E. coli. Thus, PGPase A is not essential for PGPase activity in E. coli.


Pssm-ID: 133477  Cd Length: 143  Bit Score: 175.03  E-value: 7.02e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 857867693  15 WHFLATGFGSGLSPIIPGTMGTLASIPLYLLLVQLPFPAY-VAVVVVSCIIGIKICQVTSDDMGVHDHGSIVWDEFAGFW 93
Cdd:cd06971    1 AHFLATGFGSGLSPIAPGTFGSLAALPLELLLSELGKVLLeLLALLLAFLLGIWAAEKTLKDLGVHDPGEIVIDEVVGQW 80
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 857867693  94 ITMSLVPMLnipaddWKWLLTGFVLFRFFDMVKPWPIGWLDARIHGGLGIMIDDIVAGIMAAISLYAV 161
Cdd:cd06971   81 IALLIVPFG------WLWGLLAFLLFRFFDIVKPGPIGWLDRKVKGGLGVMLDDILAGLYAALVLRLL 142
PgpA pfam04608
Phosphatidylglycerophosphatase A; This family represents a family of bacterial ...
17-162 6.80e-38

Phosphatidylglycerophosphatase A; This family represents a family of bacterial phosphatidylglycerophosphatases (EC:3.1.3.27), known as PgpA. It appears that bacteria possess several phosphatidylglycerophosphatases, and thus, PgpA is not essential in Escherichia coli.


Pssm-ID: 461365  Cd Length: 136  Bit Score: 126.55  E-value: 6.80e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 857867693   17 FLATGFGSGLSPIIPGTMGTLASIPLYLLLVQ---LPFPAYVAVVVVSCIIGIKICQVTSDDMGVHDHGSIVWDEFAGFW 93
Cdd:pfam04608   1 LIATLFGLGLLPFAPGTWGSLAALPLALLLVLskpLSLILLLVALLLLFLLGIYAADKAEKDLGKKDPGEIVIDEVLGQL 80
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 857867693   94 ITMSLVpmlnipaddwkwLLTGFVLFRFFDMVKPWPIGWLDaRIHGGLGIMIDDIVAGIMAAISLYAVA 162
Cdd:pfam04608  81 IALLFL------------LLAGFVLFRFFDILKPWPISKLD-RLPGGWGVMLDDILAGLYAALLLLLLH 136
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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