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Conserved domains on  [gi|758369613|emb|CEP08141|]
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hypothetical protein [Parasitella parasitica]

Protein Classification

GATA-type transcription factor( domain architecture ID 13755061)

GATA-type transcription factor containing a DUF1752 domain, binds to the DNA consensus sequence [AT]GATA[AG] and may function as a transcription factor/regulator

CATH:  3.30.50.10
Gene Ontology:  GO:0003700|GO:0006357|GO:0008270|GO:0043565
PubMed:  31574210
SCOP:  4003617

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ZnF_GATA cd00202
Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] ...
 233-283 1.90e-22

Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C


:

Pssm-ID: 238123 [Multi-domain]  Cd Length: 54  Bit Score: 90.12  E-value: 1.90e-22
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 758369613 233 QCHNCSTQTTPLWRRDPS-GNPLCNACGLFLKLHGVVRPLSLKT-DVIKKRNR 283
Cdd:cd00202    1 ACSNCGTTTTPLWRRGPSgGSTLCNACGLYWKKHGVMRPLSKRKkDQIKRRNR 53
DUF1752 pfam08550
Fungal protein of unknown function (DUF1752); This is a family of fungal proteins of unknown ...
 50-77 2.76e-13

Fungal protein of unknown function (DUF1752); This is a family of fungal proteins of unknown function. This short section domain is bounded by two highly conserved tryptophans. The family contains Swiss:P34072 that is thought to be a negative regulator of RAS-cAMP pathway in S.cerevisiae. the Sch.pombe member is a GAF1 transcription factor Swiss:Q10280 that is also associated with the zinc finger family GATA pfam00320.


:

Pssm-ID: 430068  Cd Length: 28  Bit Score: 63.63  E-value: 2.76e-13
                          10        20
                  ....*....|....*....|....*...
gi 758369613   50 IWRMYTKAKDTLPNGSRLENLTWRMMAM 77
Cdd:pfam08550   1 LWKVYTKCKDSLPNGERLENLSWRLWNK 28
GAT1 super family cl35034
GATA Zn-finger-containing transcription factor [Transcription];
182-285 7.68e-12

GATA Zn-finger-containing transcription factor [Transcription];


The actual alignment was detected with superfamily member COG5641:

Pssm-ID: 227928 [Multi-domain]  Cd Length: 498  Bit Score: 67.59  E-value: 7.68e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758369613 182 FTGSSSTAAINIAPAPVNNNHIEYADSPS------PSVTSVEEDSHQQHKTQhNGQTQCHNCSTQTTPLWRRDPS----- 250
Cdd:COG5641  104 FPISSSSSTSNAASPSTNYTDESNQQFSSynttlnPGGTSSLNPNNNQSDNS-NQPHVCSNCKTTSTPLWRRASSesslp 182

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 758369613 251 GNPLCNACGLFLKLHGVVR-PLSLKTDVIKKRNRGV 285
Cdd:COG5641  183 GNNLCNACGLYLKLHGSPRaPISLKSDSIKSRSSRS 218
 
Name Accession Description Interval E-value
ZnF_GATA cd00202
Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] ...
 233-283 1.90e-22

Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C


Pssm-ID: 238123 [Multi-domain]  Cd Length: 54  Bit Score: 90.12  E-value: 1.90e-22
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 758369613 233 QCHNCSTQTTPLWRRDPS-GNPLCNACGLFLKLHGVVRPLSLKT-DVIKKRNR 283
Cdd:cd00202    1 ACSNCGTTTTPLWRRGPSgGSTLCNACGLYWKKHGVMRPLSKRKkDQIKRRNR 53
ZnF_GATA smart00401
zinc finger binding to DNA consensus sequence [AT]GATA[AG];
233-278 5.39e-20

zinc finger binding to DNA consensus sequence [AT]GATA[AG];


Pssm-ID: 214648 [Multi-domain]  Cd Length: 52  Bit Score: 83.24  E-value: 5.39e-20
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 758369613   233 QCHNCSTQTTPLWRRDPSGN-PLCNACGLFLKLHGVV-RPLSLKTDVI 278
Cdd:smart00401   5 SCSNCGTTETPLWRRGPSGNkTLCNACGLYYKKHGGLkRPLSLKKDGI 52
GATA pfam00320
GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This ...
 234-267 3.19e-15

GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This domain binds to DNA. Two GATA zinc fingers are found in the GATA transcription factors. However there are several proteins which only contain a single copy of the domain.


Pssm-ID: 425605 [Multi-domain]  Cd Length: 36  Bit Score: 69.27  E-value: 3.19e-15
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 758369613  234 CHNCSTQTTPLWRRDPSGNP-LCNACGLFLKLHGV 267
Cdd:pfam00320   1 CSNCGTTKTPLWRRGPNGNRtLCNACGLYYKKKGL 35
DUF1752 pfam08550
Fungal protein of unknown function (DUF1752); This is a family of fungal proteins of unknown ...
 50-77 2.76e-13

Fungal protein of unknown function (DUF1752); This is a family of fungal proteins of unknown function. This short section domain is bounded by two highly conserved tryptophans. The family contains Swiss:P34072 that is thought to be a negative regulator of RAS-cAMP pathway in S.cerevisiae. the Sch.pombe member is a GAF1 transcription factor Swiss:Q10280 that is also associated with the zinc finger family GATA pfam00320.


Pssm-ID: 430068  Cd Length: 28  Bit Score: 63.63  E-value: 2.76e-13
                          10        20
                  ....*....|....*....|....*...
gi 758369613   50 IWRMYTKAKDTLPNGSRLENLTWRMMAM 77
Cdd:pfam08550   1 LWKVYTKCKDSLPNGERLENLSWRLWNK 28
GAT1 COG5641
GATA Zn-finger-containing transcription factor [Transcription];
182-285 7.68e-12

GATA Zn-finger-containing transcription factor [Transcription];


Pssm-ID: 227928 [Multi-domain]  Cd Length: 498  Bit Score: 67.59  E-value: 7.68e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758369613 182 FTGSSSTAAINIAPAPVNNNHIEYADSPS------PSVTSVEEDSHQQHKTQhNGQTQCHNCSTQTTPLWRRDPS----- 250
Cdd:COG5641  104 FPISSSSSTSNAASPSTNYTDESNQQFSSynttlnPGGTSSLNPNNNQSDNS-NQPHVCSNCKTTSTPLWRRASSesslp 182

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 758369613 251 GNPLCNACGLFLKLHGVVR-PLSLKTDVIKKRNRGV 285
Cdd:COG5641  183 GNNLCNACGLYLKLHGSPRaPISLKSDSIKSRSSRS 218
GAT1 COG5641
GATA Zn-finger-containing transcription factor [Transcription];
232-285 2.88e-04

GATA Zn-finger-containing transcription factor [Transcription];


Pssm-ID: 227928 [Multi-domain]  Cd Length: 498  Bit Score: 43.32  E-value: 2.88e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 758369613 232 TQCHNcSTQTTPLWRRDPSGNPLCNACGLFLKLHGVVRPLSLKTDVIKKRNRGV 285
Cdd:COG5641  301 STLTT-STATPLWRRTSDKSSFSCNASGSALKPPGSKRPLLPKPDPNSKRSNAT 353
 
Name Accession Description Interval E-value
ZnF_GATA cd00202
Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] ...
 233-283 1.90e-22

Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C


Pssm-ID: 238123 [Multi-domain]  Cd Length: 54  Bit Score: 90.12  E-value: 1.90e-22
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 758369613 233 QCHNCSTQTTPLWRRDPS-GNPLCNACGLFLKLHGVVRPLSLKT-DVIKKRNR 283
Cdd:cd00202    1 ACSNCGTTTTPLWRRGPSgGSTLCNACGLYWKKHGVMRPLSKRKkDQIKRRNR 53
ZnF_GATA smart00401
zinc finger binding to DNA consensus sequence [AT]GATA[AG];
233-278 5.39e-20

zinc finger binding to DNA consensus sequence [AT]GATA[AG];


Pssm-ID: 214648 [Multi-domain]  Cd Length: 52  Bit Score: 83.24  E-value: 5.39e-20
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 758369613   233 QCHNCSTQTTPLWRRDPSGN-PLCNACGLFLKLHGVV-RPLSLKTDVI 278
Cdd:smart00401   5 SCSNCGTTETPLWRRGPSGNkTLCNACGLYYKKHGGLkRPLSLKKDGI 52
GATA pfam00320
GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This ...
 234-267 3.19e-15

GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This domain binds to DNA. Two GATA zinc fingers are found in the GATA transcription factors. However there are several proteins which only contain a single copy of the domain.


Pssm-ID: 425605 [Multi-domain]  Cd Length: 36  Bit Score: 69.27  E-value: 3.19e-15
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 758369613  234 CHNCSTQTTPLWRRDPSGNP-LCNACGLFLKLHGV 267
Cdd:pfam00320   1 CSNCGTTKTPLWRRGPNGNRtLCNACGLYYKKKGL 35
DUF1752 pfam08550
Fungal protein of unknown function (DUF1752); This is a family of fungal proteins of unknown ...
 50-77 2.76e-13

Fungal protein of unknown function (DUF1752); This is a family of fungal proteins of unknown function. This short section domain is bounded by two highly conserved tryptophans. The family contains Swiss:P34072 that is thought to be a negative regulator of RAS-cAMP pathway in S.cerevisiae. the Sch.pombe member is a GAF1 transcription factor Swiss:Q10280 that is also associated with the zinc finger family GATA pfam00320.


Pssm-ID: 430068  Cd Length: 28  Bit Score: 63.63  E-value: 2.76e-13
                          10        20
                  ....*....|....*....|....*...
gi 758369613   50 IWRMYTKAKDTLPNGSRLENLTWRMMAM 77
Cdd:pfam08550   1 LWKVYTKCKDSLPNGERLENLSWRLWNK 28
GAT1 COG5641
GATA Zn-finger-containing transcription factor [Transcription];
182-285 7.68e-12

GATA Zn-finger-containing transcription factor [Transcription];


Pssm-ID: 227928 [Multi-domain]  Cd Length: 498  Bit Score: 67.59  E-value: 7.68e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758369613 182 FTGSSSTAAINIAPAPVNNNHIEYADSPS------PSVTSVEEDSHQQHKTQhNGQTQCHNCSTQTTPLWRRDPS----- 250
Cdd:COG5641  104 FPISSSSSTSNAASPSTNYTDESNQQFSSynttlnPGGTSSLNPNNNQSDNS-NQPHVCSNCKTTSTPLWRRASSesslp 182

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 758369613 251 GNPLCNACGLFLKLHGVVR-PLSLKTDVIKKRNRGV 285
Cdd:COG5641  183 GNNLCNACGLYLKLHGSPRaPISLKSDSIKSRSSRS 218
GAT1 COG5641
GATA Zn-finger-containing transcription factor [Transcription];
232-285 2.88e-04

GATA Zn-finger-containing transcription factor [Transcription];


Pssm-ID: 227928 [Multi-domain]  Cd Length: 498  Bit Score: 43.32  E-value: 2.88e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 758369613 232 TQCHNcSTQTTPLWRRDPSGNPLCNACGLFLKLHGVVRPLSLKTDVIKKRNRGV 285
Cdd:COG5641  301 STLTT-STATPLWRRTSDKSSFSCNASGSALKPPGSKRPLLPKPDPNSKRSNAT 353
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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