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Conserved domains on  [gi|801468936|emb|CFH29909|]
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Probable fatty acyl CoA thioesterase type III FcoT [Mycobacterium tuberculosis]

Protein Classification

FcoT family thioesterase( domain architecture ID 10566822)

FcoT family thioesterase adopts an alpha/beta hotdog fold, and is similar to Mycobacterium tuberculosis Rv0098/FcoT, a long-chain fatty acyl-CoA thioesterase

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FcoT pfam10862
FcoT-like thioesterase domain; Proteins in this family have a HotDog fold. This family was ...
 28-178 7.37e-87

FcoT-like thioesterase domain; Proteins in this family have a HotDog fold. This family was formerly known as domain of unknown function 2662 (DUF2662). The structure of Rv0098 from M. tuberculosis suggested a thioesterase function. Assays showed that this protein was a thioesterase with a preference for long chain fatty acyl groups. The maximal Kcat was observed for palmitoyl-CoA although longer and shorter molecules were also cleaved. In solution this protein forms a homo-hexameric complex.


:

Pssm-ID: 431526  Cd Length: 150  Bit Score: 251.85  E-value: 7.37e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 801468936   28 RVLEPYScKGCRYLIDAQYSATEDSVLAYGNFTIGESAYIRSTGHFNAVELILCFNQLAYSAFAPAVLNEEIRVLRGWSI 107
Cdd:pfam10862   1 RVLEPYK-KNCRYLKSAQVRYSGDSVTARGEFSIPESCYIDDTGHFNAVEFNICYNQLAYYLLAHAVRNRLVPAFAAWTI 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 801468936  108 DDYCQHQLSSMLIRKASSRFRKPLNPQKFSARLLCRDLQVIERTWRYLKVPCVIEFWDENGGAASGEIELA 178
Cdd:pfam10862  80 EDYWRRQLPDILITRFSSRFRKPINPRDFSGELEITDLRERGRGWPLLFLKTSCRFWDDNGGRAEGEITLA 150
 
Name Accession Description Interval E-value
FcoT pfam10862
FcoT-like thioesterase domain; Proteins in this family have a HotDog fold. This family was ...
 28-178 7.37e-87

FcoT-like thioesterase domain; Proteins in this family have a HotDog fold. This family was formerly known as domain of unknown function 2662 (DUF2662). The structure of Rv0098 from M. tuberculosis suggested a thioesterase function. Assays showed that this protein was a thioesterase with a preference for long chain fatty acyl groups. The maximal Kcat was observed for palmitoyl-CoA although longer and shorter molecules were also cleaved. In solution this protein forms a homo-hexameric complex.


Pssm-ID: 431526  Cd Length: 150  Bit Score: 251.85  E-value: 7.37e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 801468936   28 RVLEPYScKGCRYLIDAQYSATEDSVLAYGNFTIGESAYIRSTGHFNAVELILCFNQLAYSAFAPAVLNEEIRVLRGWSI 107
Cdd:pfam10862   1 RVLEPYK-KNCRYLKSAQVRYSGDSVTARGEFSIPESCYIDDTGHFNAVEFNICYNQLAYYLLAHAVRNRLVPAFAAWTI 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 801468936  108 DDYCQHQLSSMLIRKASSRFRKPLNPQKFSARLLCRDLQVIERTWRYLKVPCVIEFWDENGGAASGEIELA 178
Cdd:pfam10862  80 EDYWRRQLPDILITRFSSRFRKPINPRDFSGELEITDLRERGRGWPLLFLKTSCRFWDDNGGRAEGEITLA 150
 
Name Accession Description Interval E-value
FcoT pfam10862
FcoT-like thioesterase domain; Proteins in this family have a HotDog fold. This family was ...
 28-178 7.37e-87

FcoT-like thioesterase domain; Proteins in this family have a HotDog fold. This family was formerly known as domain of unknown function 2662 (DUF2662). The structure of Rv0098 from M. tuberculosis suggested a thioesterase function. Assays showed that this protein was a thioesterase with a preference for long chain fatty acyl groups. The maximal Kcat was observed for palmitoyl-CoA although longer and shorter molecules were also cleaved. In solution this protein forms a homo-hexameric complex.


Pssm-ID: 431526  Cd Length: 150  Bit Score: 251.85  E-value: 7.37e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 801468936   28 RVLEPYScKGCRYLIDAQYSATEDSVLAYGNFTIGESAYIRSTGHFNAVELILCFNQLAYSAFAPAVLNEEIRVLRGWSI 107
Cdd:pfam10862   1 RVLEPYK-KNCRYLKSAQVRYSGDSVTARGEFSIPESCYIDDTGHFNAVEFNICYNQLAYYLLAHAVRNRLVPAFAAWTI 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 801468936  108 DDYCQHQLSSMLIRKASSRFRKPLNPQKFSARLLCRDLQVIERTWRYLKVPCVIEFWDENGGAASGEIELA 178
Cdd:pfam10862  80 EDYWRRQLPDILITRFSSRFRKPINPRDFSGELEITDLRERGRGWPLLFLKTSCRFWDDNGGRAEGEITLA 150
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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