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Conserved domains on  [gi|802036281|emb|CFO96580|]
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4-diphosphocytidyl-2-C-methyl-D-erythritol kinase [Bordetella pertussis]

Protein Classification

4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase( domain architecture ID 11449259)

4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol in isoprenoid biosynthesis

CATH:  3.30.230.10
EC:  2.7.1.148
Gene Ontology:  GO:0050515|GO:0005524|GO:0016310|GO:0016114
PubMed:  12878729
SCOP:  4000959|4000643

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
IspE COG1947
4-diphosphocytidyl-2C-methyl-D-erythritol kinase [Lipid transport and metabolism]; ...
 4-267 2.74e-110

4-diphosphocytidyl-2C-methyl-D-erythritol kinase [Lipid transport and metabolism]; 4-diphosphocytidyl-2C-methyl-D-erythritol kinase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


:

Pssm-ID: 441550 [Multi-domain]  Cd Length: 281  Bit Score: 320.92  E-value: 2.74e-110
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 802036281   4 YDVPAPAKLNLFLHVVGRRADGYHLLQTAFRFIDLADTLHFEARADGAIGRAYELPGVAES-DDLVMRAARSLQRATGTR 82
Cdd:COG1947    2 LTVKAPAKINLFLHVTGRRPDGYHELETVFQFIDLGDTLTIEPADDGSISLTGPGAGVPTDeDNLVYRAARLLQEATGIP 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 802036281  83 QGAQIGLHKRIPqggglgggSSDAATTLIALNRLWGTGLSRSQLMQLALPLGADVPVFVFGQSAFAQGVGEDLTAV-ALS 161
Cdd:COG1947   82 PGVDIHLEKRIPvgaglgggSSDAAATLRALNRLWGLGLSREELAELAAKLGADVPFFLYGGTALAEGRGEKLTPLpPLP 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 802036281 162 PAAYLVVQPDAGVPTAVIFSDPDLTRDCASVTIADFLALPTSC------FGRNDLEPVVLRRYPEVSGAVRWLFEHG-LR 234
Cdd:COG1947  162 ELWLVLVKPGVGVSTAEVYRALDLTRDTPPPDIDALLAALAAGdaalaaLLRNDLEPVAFKLYPEIAEVLEALLEAGaLA 241

                        250       260       270
                 ....*....|....*....|....*....|...
gi 802036281 235 VRMSGSGACLFAEFPTLPEAVLAQEEITATMRV 267
Cdd:COG1947  242 ARMSGSGSTVFGLFEDEEAAEAAAAALPARGGV 274
 
Name Accession Description Interval E-value
IspE COG1947
4-diphosphocytidyl-2C-methyl-D-erythritol kinase [Lipid transport and metabolism]; ...
 4-267 2.74e-110

4-diphosphocytidyl-2C-methyl-D-erythritol kinase [Lipid transport and metabolism]; 4-diphosphocytidyl-2C-methyl-D-erythritol kinase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


Pssm-ID: 441550 [Multi-domain]  Cd Length: 281  Bit Score: 320.92  E-value: 2.74e-110
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 802036281   4 YDVPAPAKLNLFLHVVGRRADGYHLLQTAFRFIDLADTLHFEARADGAIGRAYELPGVAES-DDLVMRAARSLQRATGTR 82
Cdd:COG1947    2 LTVKAPAKINLFLHVTGRRPDGYHELETVFQFIDLGDTLTIEPADDGSISLTGPGAGVPTDeDNLVYRAARLLQEATGIP 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 802036281  83 QGAQIGLHKRIPqggglgggSSDAATTLIALNRLWGTGLSRSQLMQLALPLGADVPVFVFGQSAFAQGVGEDLTAV-ALS 161
Cdd:COG1947   82 PGVDIHLEKRIPvgaglgggSSDAAATLRALNRLWGLGLSREELAELAAKLGADVPFFLYGGTALAEGRGEKLTPLpPLP 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 802036281 162 PAAYLVVQPDAGVPTAVIFSDPDLTRDCASVTIADFLALPTSC------FGRNDLEPVVLRRYPEVSGAVRWLFEHG-LR 234
Cdd:COG1947  162 ELWLVLVKPGVGVSTAEVYRALDLTRDTPPPDIDALLAALAAGdaalaaLLRNDLEPVAFKLYPEIAEVLEALLEAGaLA 241

                        250       260       270
                 ....*....|....*....|....*....|...
gi 802036281 235 VRMSGSGACLFAEFPTLPEAVLAQEEITATMRV 267
Cdd:COG1947  242 ARMSGSGSTVFGLFEDEEAAEAAAAALPARGGV 274
ispE TIGR00154
4-diphosphocytidyl-2C-methyl-D-erythritol kinase; Members of this family of GHMP kinases were ...
 7-258 2.74e-72

4-diphosphocytidyl-2C-methyl-D-erythritol kinase; Members of this family of GHMP kinases were previously designated as conserved hypothetical protein YchB or as isopentenyl monophosphate kinase. It is now known, in tomato and E. coli, to encode 4-diphosphocytidyl-2C-methyl-D-erythritol kinase, an enzyme of the deoxyxylulose phosphate pathway of terpenoid biosynthesis. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other]


Pssm-ID: 188029 [Multi-domain]  Cd Length: 294  Bit Score: 224.70  E-value: 2.74e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 802036281    7 PAPAKLNLFLHVVGRRADGYHLLQTAFRFIDLADTLHFEARADGAIGRAYELPGVAESDDLVMRAARSLQ----RATGTR 82
Cdd:TIGR00154   6 PAPAKINLFLYILGKRPDGYHELQMLMQFIDLGDKIIISVRSDDDIRLLKGDFDVPLEENLAYRAAQLLKnfanSKIKSL 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 802036281   83 QGAQIGLHKRIPQGGGLGGGSSDAATTLIALNRLWGTGLSRSQLMQLALPLGADVPVFVFGQSAFAQGVGEDLTAVALSP 162
Cdd:TIGR00154  86 DGVNIEITKNIPMAAGLGGGSSDAAAVLVGLNQLWNLGLSLEELAELGATLGADVPFFVSGGTAFATGRGEIITPFEDPP 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 802036281  163 AAYLVV-QPDAGVPTAVIFSDPDLTRDCAS----VTIADFLALPT--SCFGRNDLEPVVLRRYPEVSGAVRWLFEHGL-R 234
Cdd:TIGR00154 166 EKWVVIaKPHVSVSTPVVYQAYKLPRNTPKrakeWLKKISLECLQllDSNGLNDLEKVALKRHTEVAQALNWLLEYGLaP 245

                         250       260
                  ....*....|....*....|....*.
gi 802036281  235 VRMSGSGACLFAEFPTLPEA--VLAQ 258
Cdd:TIGR00154 246 ERMSGSGPCVFALFDMESEAeqVLEQ 271
PRK14608 PRK14608
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional
 8-263 1.84e-54

4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional


Pssm-ID: 237765 [Multi-domain]  Cd Length: 290  Bit Score: 178.51  E-value: 1.84e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 802036281   8 APAKLNLFLHVVGRRADGYHLLQTAFRFIDLADTLHFE-ARADG--AIGR-AYELPgvAESDDLVMRAARSLQRATGTR- 82
Cdd:PRK14608  11 APAKINLALHVTGRRADGYHLLESLVAFADVGDRLTLEpAEALSltVSGPfAAGLG--DGDDNLVLRAARALRARVGPGl 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 802036281  83 QGAQIGLHKRIPQGGGLGGGSSDAATTLIALNRLWGTGLSRSQLMQLALPLGADVPVFVFGQSAFAQGVGEDLTAVA-LS 161
Cdd:PRK14608  89 PPGAFHLEKNLPVAAGIGGGSADAAAALRLLARLWGLALDDERLAALALSLGADVPVCLDSRPLIMRGIGEELTPLPgLP 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 802036281 162 PAAYLVVQPDAGVPTAVIFSDPDLTRDCASVTIADFLALPTSC-----FGRNDLEPVVLRRYPEVSGAVRWLFEHG--LR 234
Cdd:PRK14608 169 SLPAVLVNPGVPVATPDVFRALGLRDGPPLPGAPDPLASADALlaalaATRNDLEPPALALAPVIGEVLAALRAQPgaLL 248

                        250       260
                 ....*....|....*....|....*....
gi 802036281 235 VRMSGSGACLFAEFPTLPEAVLAQEEITA 263
Cdd:PRK14608 249 ARMSGSGATCFALFADEAAAEAAAAAIAA 277
GHMP_kinases_C pfam08544
GHMP kinases C terminal; This family includes homoserine kinases, galactokinases and ...
 208-266 5.79e-06

GHMP kinases C terminal; This family includes homoserine kinases, galactokinases and mevalonate kinases.


Pssm-ID: 430063 [Multi-domain]  Cd Length: 85  Bit Score: 43.61  E-value: 5.79e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 802036281  208 NDLEPVVLRR--YPEVSGAVRWLFEHGLRVRMSGS--GACLFAEFPTLPEAVLAQEEITATMR 266
Cdd:pfam08544  22 ESLEPLLVVGilPPELDELLEALLELGLGAKLSGSggGPTVFALFKDEDDAEEVARALREAGK 84
 
Name Accession Description Interval E-value
IspE COG1947
4-diphosphocytidyl-2C-methyl-D-erythritol kinase [Lipid transport and metabolism]; ...
 4-267 2.74e-110

4-diphosphocytidyl-2C-methyl-D-erythritol kinase [Lipid transport and metabolism]; 4-diphosphocytidyl-2C-methyl-D-erythritol kinase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


Pssm-ID: 441550 [Multi-domain]  Cd Length: 281  Bit Score: 320.92  E-value: 2.74e-110
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 802036281   4 YDVPAPAKLNLFLHVVGRRADGYHLLQTAFRFIDLADTLHFEARADGAIGRAYELPGVAES-DDLVMRAARSLQRATGTR 82
Cdd:COG1947    2 LTVKAPAKINLFLHVTGRRPDGYHELETVFQFIDLGDTLTIEPADDGSISLTGPGAGVPTDeDNLVYRAARLLQEATGIP 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 802036281  83 QGAQIGLHKRIPqggglgggSSDAATTLIALNRLWGTGLSRSQLMQLALPLGADVPVFVFGQSAFAQGVGEDLTAV-ALS 161
Cdd:COG1947   82 PGVDIHLEKRIPvgaglgggSSDAAATLRALNRLWGLGLSREELAELAAKLGADVPFFLYGGTALAEGRGEKLTPLpPLP 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 802036281 162 PAAYLVVQPDAGVPTAVIFSDPDLTRDCASVTIADFLALPTSC------FGRNDLEPVVLRRYPEVSGAVRWLFEHG-LR 234
Cdd:COG1947  162 ELWLVLVKPGVGVSTAEVYRALDLTRDTPPPDIDALLAALAAGdaalaaLLRNDLEPVAFKLYPEIAEVLEALLEAGaLA 241

                        250       260       270
                 ....*....|....*....|....*....|...
gi 802036281 235 VRMSGSGACLFAEFPTLPEAVLAQEEITATMRV 267
Cdd:COG1947  242 ARMSGSGSTVFGLFEDEEAAEAAAAALPARGGV 274
ispE TIGR00154
4-diphosphocytidyl-2C-methyl-D-erythritol kinase; Members of this family of GHMP kinases were ...
 7-258 2.74e-72

4-diphosphocytidyl-2C-methyl-D-erythritol kinase; Members of this family of GHMP kinases were previously designated as conserved hypothetical protein YchB or as isopentenyl monophosphate kinase. It is now known, in tomato and E. coli, to encode 4-diphosphocytidyl-2C-methyl-D-erythritol kinase, an enzyme of the deoxyxylulose phosphate pathway of terpenoid biosynthesis. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other]


Pssm-ID: 188029 [Multi-domain]  Cd Length: 294  Bit Score: 224.70  E-value: 2.74e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 802036281    7 PAPAKLNLFLHVVGRRADGYHLLQTAFRFIDLADTLHFEARADGAIGRAYELPGVAESDDLVMRAARSLQ----RATGTR 82
Cdd:TIGR00154   6 PAPAKINLFLYILGKRPDGYHELQMLMQFIDLGDKIIISVRSDDDIRLLKGDFDVPLEENLAYRAAQLLKnfanSKIKSL 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 802036281   83 QGAQIGLHKRIPQGGGLGGGSSDAATTLIALNRLWGTGLSRSQLMQLALPLGADVPVFVFGQSAFAQGVGEDLTAVALSP 162
Cdd:TIGR00154  86 DGVNIEITKNIPMAAGLGGGSSDAAAVLVGLNQLWNLGLSLEELAELGATLGADVPFFVSGGTAFATGRGEIITPFEDPP 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 802036281  163 AAYLVV-QPDAGVPTAVIFSDPDLTRDCAS----VTIADFLALPT--SCFGRNDLEPVVLRRYPEVSGAVRWLFEHGL-R 234
Cdd:TIGR00154 166 EKWVVIaKPHVSVSTPVVYQAYKLPRNTPKrakeWLKKISLECLQllDSNGLNDLEKVALKRHTEVAQALNWLLEYGLaP 245

                         250       260
                  ....*....|....*....|....*.
gi 802036281  235 VRMSGSGACLFAEFPTLPEA--VLAQ 258
Cdd:TIGR00154 246 ERMSGSGPCVFALFDMESEAeqVLEQ 271
PRK14608 PRK14608
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional
 8-263 1.84e-54

4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional


Pssm-ID: 237765 [Multi-domain]  Cd Length: 290  Bit Score: 178.51  E-value: 1.84e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 802036281   8 APAKLNLFLHVVGRRADGYHLLQTAFRFIDLADTLHFE-ARADG--AIGR-AYELPgvAESDDLVMRAARSLQRATGTR- 82
Cdd:PRK14608  11 APAKINLALHVTGRRADGYHLLESLVAFADVGDRLTLEpAEALSltVSGPfAAGLG--DGDDNLVLRAARALRARVGPGl 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 802036281  83 QGAQIGLHKRIPQGGGLGGGSSDAATTLIALNRLWGTGLSRSQLMQLALPLGADVPVFVFGQSAFAQGVGEDLTAVA-LS 161
Cdd:PRK14608  89 PPGAFHLEKNLPVAAGIGGGSADAAAALRLLARLWGLALDDERLAALALSLGADVPVCLDSRPLIMRGIGEELTPLPgLP 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 802036281 162 PAAYLVVQPDAGVPTAVIFSDPDLTRDCASVTIADFLALPTSC-----FGRNDLEPVVLRRYPEVSGAVRWLFEHG--LR 234
Cdd:PRK14608 169 SLPAVLVNPGVPVATPDVFRALGLRDGPPLPGAPDPLASADALlaalaATRNDLEPPALALAPVIGEVLAALRAQPgaLL 248

                        250       260
                 ....*....|....*....|....*....
gi 802036281 235 VRMSGSGACLFAEFPTLPEAVLAQEEITA 263
Cdd:PRK14608 249 ARMSGSGATCFALFADEAAAEAAAAAIAA 277
PRK14611 PRK14611
4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase;
8-246 2.49e-31

4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase;


Pssm-ID: 184767 [Multi-domain]  Cd Length: 275  Bit Score: 117.93  E-value: 2.49e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 802036281   8 APAKLNLFLHVVGRRADGYHLLQTAFRFIDLADTLHfearadgaIGRAYEL------PGVAESDDLVMRAARSLQRATGT 81
Cdd:PRK14611   6 SPAKVNLGLWILGKRPDGYHEIFTIYHTIDLYDRIY--------IKEHHTLevktssPQIKEEENIVYKALRLFERYTGI 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 802036281  82 RQGAQIGLHKRIPQGGGLGGGSSDAATTLIALNRLWGTGLSRSQLMQLALPLGADVPVFVFGQSAFAQGVGEDLTAV--A 159
Cdd:PRK14611  78 DINYSIFIEKNIPVGAGLGGGSSNAAVVLKYLNELLGNPLSEEELFELASSISADAPFFLKGGFALGRGIGDKLEFLekP 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 802036281 160 LSPAAYLVVqPDAGVPTAVIFSdpdlTRDCASVTIADFLALPTSC---FGRNDLEPVV--------LRRYPEVSGAVRWL 228
Cdd:PRK14611 158 ISREITLVY-PNIKSSTGRVYS----KVTKQILTNKEDLNIIISLlreGEEKKIEEVIentlgeiaLELYPEIKEVYRFL 232

                        250
                 ....*....|....*...
gi 802036281 229 FEHGLRVRMSGSGACLFA 246
Cdd:PRK14611 233 EYLGYKPFVSGSGSSVYV 250
PRK03188 PRK03188
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional
 6-193 1.75e-28

4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional


Pssm-ID: 235110 [Multi-domain]  Cd Length: 300  Bit Score: 110.75  E-value: 1.75e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 802036281   6 VPAPAKLNLFLHVVGRRADGYHLLQTAFRFIDLADTLhfEARADGAIGRAYELPGVAE----SDDLVMRAARSLQRATGT 81
Cdd:PRK03188   3 VRAPAKVNLHLGVGPLRDDGYHELATVFQAVSLYDEV--TVTAADVLSVEVSGEGADQvptdESNLAWRAAELLAEHVGR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 802036281  82 RQGAQIGLHKRIPQGGGLGGGSSDAATTLIALNRLWGTGLSRSQLMQLALPLGADVPVFVFGQSAFAQGVGEDLTAVaLS 161
Cdd:PRK03188  81 APDVHLHIDKGIPVAGGMAGGSADAAAALVACDALWGLGLSRDELLELAAELGSDVPFALLGGTALGTGRGEQLAPV-LA 159

                        170       180       190
                 ....*....|....*....|....*....|....
gi 802036281 162 PAAY--LVVQPDAGVPTAVIFSDPDLTRDCASVT 193
Cdd:PRK03188 160 RGTFhwVLAFADGGLSTPAVFRELDRLREAGDPP 193
PRK04181 PRK04181
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional
 10-153 1.38e-18

4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional


Pssm-ID: 235243  Cd Length: 257  Bit Score: 83.09  E-value: 1.38e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 802036281  10 AKLNLFLHVVGRRaDGYHLLQTAF-RFIDLADTLHFEARAdgaiGRAYELPG---VAESDDLVMRAARSLQRATGTR--- 82
Cdd:PRK04181   7 AKVNIFLKILGKR-GNYHELISRFvLVKDLFDEIEFVPKS----AESFELIGnfdCPLEENIIYKAYQELKNKGFSNeli 81

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 802036281  83 ---QGAQIGLHKRIPQGGGLGGGSSDAATTLIALNRLWGTGLSRSQLMQLALPLGADVPVFVFG-QSAFAQGVGE 153
Cdd:PRK04181  82 effKKKAIEVEKNIPTGAGLGGGSSDAATFLLMLNEILNLKLSLEELAEIGSKVGADVAFFISGyKSANVSGIGE 156
PRK14613 PRK14613
4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase;
8-266 1.02e-16

4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase;


Pssm-ID: 173077 [Multi-domain]  Cd Length: 297  Bit Score: 78.79  E-value: 1.02e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 802036281   8 APAKLNLFLHVVGRRADGYHLLQTAFRFIDLADTLHFEARADGA---------IGRAYEL-PGVAESDDL-------VMR 70
Cdd:PRK14613   3 SPAKINLGLEIPFKREDGFHEIRSVFLKISWGDDIEIEPAPNGVfelfstneiILEKRKLyDQVSERGDIkqnilykTFI 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 802036281  71 AARSL-QRATGTRqgaqIGLHKRIPQGGGLGGGSSDAATTLialNRLWG-TGLSRSQLMQ-LALPLGADVPVFVFGQSAF 147
Cdd:PRK14613  83 KARSLfPELPGVK----IHLTKRISPAGGLGGGSTNAASLL---NFLFSwRNFFTSDEMQvFAKEIGSDVPFFLGEGHAF 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 802036281 148 AQGVGEDLTAVALSPAAYLVVQPDAGVPTAVIFSD--------------PDLTRDCASV-TIADFLALPtscfGR--NDL 210
Cdd:PRK14613 156 VTGKGEIMEEIEVHKGQGILALTPQVMNTGEMYALlkkplqesasqkngNTLSEDLISSlKVGDWVSLQ----GRleNDF 231

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 802036281 211 EPVVLRRYPEVSGAVRWLFEHG-LRVRMSGSGACLFAEFPTLPEavlaQEEITATMR 266
Cdd:PRK14613 232 EPVAFQLHPELGVLKDKFLEFGsSYCSLTGSGSSMYGLVQGLEI----QEELLPRLR 284
GHMP_kinases_C pfam08544
GHMP kinases C terminal; This family includes homoserine kinases, galactokinases and ...
 208-266 5.79e-06

GHMP kinases C terminal; This family includes homoserine kinases, galactokinases and mevalonate kinases.


Pssm-ID: 430063 [Multi-domain]  Cd Length: 85  Bit Score: 43.61  E-value: 5.79e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 802036281  208 NDLEPVVLRR--YPEVSGAVRWLFEHGLRVRMSGS--GACLFAEFPTLPEAVLAQEEITATMR 266
Cdd:pfam08544  22 ESLEPLLVVGilPPELDELLEALLELGLGAKLSGSggGPTVFALFKDEDDAEEVARALREAGK 84
PRK05905 PRK05905
4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase;
64-245 6.94e-05

4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase;


Pssm-ID: 235642  Cd Length: 258  Bit Score: 43.30  E-value: 6.94e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 802036281  64 SDDLVMRAARSLQRATGTRQGAQIGLHKRIPQGGGLGGGSSDAATTLIALNRLwgTGLSRSQLMQLALPLGADVPVFVFG 143
Cdd:PRK05905  66 SRLILVKTLEWLRDKYNIKNHFKIKIKKRIPIGSGLGSGSSNAAVLMKWILEF--EGINEINYKDVVNKLGSDIPFFLSG 143

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 802036281 144 -QSAFAQGVGEDLTAVALSPA-AYLVVQPDAGVPTAVIFSDPDLTRDCAS---VTIADFLALPTSCFGRNDLEPVVLRRY 218
Cdd:PRK05905 144 yKTAYISDYGSQVEDLIGQFKlTYKVIFMNVNVSTKKVFEKFDDNQHVIKnnfKTIIKNLKENIVVNIHNDLQEPCFELY 223

                        170       180
                 ....*....|....*....|....*..
gi 802036281 219 PEVSGAVRWLFEHGLRVRMSGSGACLF 245
Cdd:PRK05905 224 PNLLYKYNELLNDGFYTILSGAGSSFI 250
GHMP_kinases_N pfam00288
GHMP kinases N terminal domain; This family includes homoserine kinases, galactokinases and ...
 89-143 3.03e-03

GHMP kinases N terminal domain; This family includes homoserine kinases, galactokinases and mevalonate kinases.


Pssm-ID: 395225 [Multi-domain]  Cd Length: 64  Bit Score: 35.60  E-value: 3.03e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 802036281   89 LHKRIPQGGGLGGGSSDAATTLIALNRLWG-----TGLSRSQLMQLALPLGADVPVFVFG 143
Cdd:pfam00288   4 IESNIPLGAGLGSSAALAVALLLALNELFGlplakLALEAEELAGGGRGGGMDVAASLYG 63
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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