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Conserved domains on  [gi|889790966|emb|CLZ89943|]
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Protein of uncharacterised function (DUF2580) [Mycobacterium tuberculosis]

Protein Classification

ESX-1 secretion-associated protein( domain architecture ID 10566755)

ESX-1 secretion-associated protein similar to ESX-1 (ESAT-6 secretion system 1) substrate protein C (EspC), an immunodominant Mycobacterium tuberculosis-secreted antigen

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
T7SS_ESX_EspC pfam10824
Excreted virulence factor EspC, type VII ESX diderm; T7SS_ESX-EspC is a family of exported ...
 1-99 2.00e-26

Excreted virulence factor EspC, type VII ESX diderm; T7SS_ESX-EspC is a family of exported virulence proteins from largely Acinetobacteria and a few Fimicutes, Gram-positive bacteria. It is exported in conjunction with EspA as an interacting pair.ED F8ADQ6.1/227-313; F8ADQ6.1/227-313;


:

Pssm-ID: 371259  Cd Length: 100  Bit Score: 93.56  E-value: 2.00e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 889790966    1 MTDRIHVQPAHLRQAAAHHQQTAYYLRTVPSSH-DAIRESLDSLGPIFSELRDTGRELLELRKQCYQQQADNHADIAQNL 79
Cdd:pfam10824   1 MTDNLHVVPAHLRSLAAQHDEAAARIATAVAAAaGAVAAVLDTHGPICAPTNDAFAAAETARRAAGTALATASTELADKL 80

                          90       100
                  ....*....|....*....|
gi 889790966   80 RTSAAMWEQHERAASRSLGN 99
Cdd:pfam10824  81 RTAAAAYERTDETAAGALDG 100
 
Name Accession Description Interval E-value
T7SS_ESX_EspC pfam10824
Excreted virulence factor EspC, type VII ESX diderm; T7SS_ESX-EspC is a family of exported ...
 1-99 2.00e-26

Excreted virulence factor EspC, type VII ESX diderm; T7SS_ESX-EspC is a family of exported virulence proteins from largely Acinetobacteria and a few Fimicutes, Gram-positive bacteria. It is exported in conjunction with EspA as an interacting pair.ED F8ADQ6.1/227-313; F8ADQ6.1/227-313;


Pssm-ID: 371259  Cd Length: 100  Bit Score: 93.56  E-value: 2.00e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 889790966    1 MTDRIHVQPAHLRQAAAHHQQTAYYLRTVPSSH-DAIRESLDSLGPIFSELRDTGRELLELRKQCYQQQADNHADIAQNL 79
Cdd:pfam10824   1 MTDNLHVVPAHLRSLAAQHDEAAARIATAVAAAaGAVAAVLDTHGPICAPTNDAFAAAETARRAAGTALATASTELADKL 80

                          90       100
                  ....*....|....*....|
gi 889790966   80 RTSAAMWEQHERAASRSLGN 99
Cdd:pfam10824  81 RTAAAAYERTDETAAGALDG 100
 
Name Accession Description Interval E-value
T7SS_ESX_EspC pfam10824
Excreted virulence factor EspC, type VII ESX diderm; T7SS_ESX-EspC is a family of exported ...
 1-99 2.00e-26

Excreted virulence factor EspC, type VII ESX diderm; T7SS_ESX-EspC is a family of exported virulence proteins from largely Acinetobacteria and a few Fimicutes, Gram-positive bacteria. It is exported in conjunction with EspA as an interacting pair.ED F8ADQ6.1/227-313; F8ADQ6.1/227-313;


Pssm-ID: 371259  Cd Length: 100  Bit Score: 93.56  E-value: 2.00e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 889790966    1 MTDRIHVQPAHLRQAAAHHQQTAYYLRTVPSSH-DAIRESLDSLGPIFSELRDTGRELLELRKQCYQQQADNHADIAQNL 79
Cdd:pfam10824   1 MTDNLHVVPAHLRSLAAQHDEAAARIATAVAAAaGAVAAVLDTHGPICAPTNDAFAAAETARRAAGTALATASTELADKL 80

                          90       100
                  ....*....|....*....|
gi 889790966   80 RTSAAMWEQHERAASRSLGN 99
Cdd:pfam10824  81 RTAAAAYERTDETAAGALDG 100
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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