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Conserved domains on  [gi|811922143|emb|CMG88705|]
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GntR family transcriptional regulator [Mycobacterium tuberculosis]

Protein Classification

GntR family transcriptional regulator( domain architecture ID 11448455)

GntR-family transcriptional regulator is one of a group of transcriptional regulators with a conserved N-terminal helix-turn-helix DNA-binding domain and a diverse C-terminal effector-binding and oligomerization domain; controls the expression of genes with diverse biological functions

CATH:  1.10.10.10
Gene Ontology:  GO:0003700|GO:0003677
PubMed:  33509775
SCOP:  4000155

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GntR COG1802
DNA-binding transcriptional regulator, GntR family [Transcription];
52-268 5.70e-40

DNA-binding transcriptional regulator, GntR family [Transcription];


:

Pssm-ID: 441407 [Multi-domain]  Cd Length: 222  Bit Score: 138.13  E-value: 5.70e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 811922143  52 SQLPLRRAQLSDEVAGHLRAAIMSGALRSGTFIRLDETAAELGVSVTPVREALLKLRGEGMVGLEPHRGHVVLPLTRQDI 131
Cdd:COG1802    3 SPSPLRRESLAEQVYEALREAILSGELPPGERLSEAELAERLGVSRTPVREALRRLEAEGLVEIRPNRGARVAPLSPEEI 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 811922143 132 DDIFWLQATIAQELATSATAHITDVEIDELDRINNALAGAIGSGDAKTIASIEFAFHRVFNKASRRIKLA------WFLL 205
Cdd:COG1802   83 RELYEVRAALEGLAARLAAERATPADLARLRALLEELEAAAAAGDVAAYLELDREFHRALVEAAGNPRLAellrrlRARL 162

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 811922143 206 NAARYMpaqvFAADPRWGADAVNSHRQLIAALRRRDTAAVIEHTVWQFTDGARRLTEALAETE 268
Cdd:COG1802  163 RRYRRL----SLRSPGRLEESLAEHRAILDALEAGDAEAAAAALRAHLERARERLLEALAAAA 221
 
Name Accession Description Interval E-value
GntR COG1802
DNA-binding transcriptional regulator, GntR family [Transcription];
52-268 5.70e-40

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441407 [Multi-domain]  Cd Length: 222  Bit Score: 138.13  E-value: 5.70e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 811922143  52 SQLPLRRAQLSDEVAGHLRAAIMSGALRSGTFIRLDETAAELGVSVTPVREALLKLRGEGMVGLEPHRGHVVLPLTRQDI 131
Cdd:COG1802    3 SPSPLRRESLAEQVYEALREAILSGELPPGERLSEAELAERLGVSRTPVREALRRLEAEGLVEIRPNRGARVAPLSPEEI 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 811922143 132 DDIFWLQATIAQELATSATAHITDVEIDELDRINNALAGAIGSGDAKTIASIEFAFHRVFNKASRRIKLA------WFLL 205
Cdd:COG1802   83 RELYEVRAALEGLAARLAAERATPADLARLRALLEELEAAAAAGDVAAYLELDREFHRALVEAAGNPRLAellrrlRARL 162

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 811922143 206 NAARYMpaqvFAADPRWGADAVNSHRQLIAALRRRDTAAVIEHTVWQFTDGARRLTEALAETE 268
Cdd:COG1802  163 RRYRRL----SLRSPGRLEESLAEHRAILDALEAGDAEAAAAALRAHLERARERLLEALAAAA 221
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 61-123 4.66e-11

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 57.07  E-value: 4.66e-11
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 811922143  61 LSDEVAGHLRAAIMSGALRSGTfiRL---DETAAELGVSVTPVREALLKLRGEGMVGLEPHRGHVV 123
Cdd:cd07377    2 LYEQIADQLREAILSGELKPGD--RLpseRELAEELGVSRTTVREALRELEAEGLVERRPGRGTFV 65
GntR pfam00392
Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the ...
 61-123 1.61e-10

Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcription factors. At the C-terminus there is usually an effector-binding/oligomerization domain. The GntR-like proteins include the following sub-families: MocR, YtrR, FadR, AraR, HutC and PlmA, DevA, DasR. Many of these proteins have been shown experimentally to be autoregulatory, enabling the prediction of operator sites and the discovery of cis/trans relationships. The DasR regulator has been shown to be a global regulator of primary metabolism and development in Streptomyces coelicolor.


Pssm-ID: 306822 [Multi-domain]  Cd Length: 64  Bit Score: 55.70  E-value: 1.61e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 811922143   61 LSDEVAGHLRAAIMSGALRSGTFI-RLDETAAELGVSVTPVREALLKLRGEGMVGLEPHRGHVV 123
Cdd:pfam00392   1 LYEQVYARLREDILSGRLRPGDKLpSERELAAEFGVSRTTVREALRRLEAEGLVERRQGRGTFV 64
PRK11414 PRK11414
GntR family transcriptional regulator;
61-244 6.21e-09

GntR family transcriptional regulator;


Pssm-ID: 183126 [Multi-domain]  Cd Length: 221  Bit Score: 54.88  E-value: 6.21e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 811922143  61 LSDEVAGHLRAAIMSGALRSGTFIRLDETAAELGVSVTPVREALLKLRGEGMVGLEPHRGHVVLPLTRQDIDDIFWLQAT 140
Cdd:PRK11414  12 LTLQVENDLKHQLSIGALKPGARLITKNLAEQLGMSITPVREALLRLVSVNALSVAPAQAFTVPEVSKRQLDEINRIRYE 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 811922143 141 IAQELATSATAHITDVEIDELDRINNALAGAIGSGDAKTIASIEFAFH-RVFNKASRRIKLAWFLLNAARYMPAQVF--- 216
Cdd:PRK11414  92 LELMAVALAVENLTPQDLAELQELLEKLQQAQEKGDMEQIINANRLFRlAIYHRSNMPILCEMIEQLWVRMGPSLHYlye 171

                        170       180
                 ....*....|....*....|....*...
gi 811922143 217 AADPRWGADAVNSHRQLIAALRRRDTAA 244
Cdd:PRK11414 172 AINPAELREHIENYRLLLAALKAKDKEG 199
HTH_GNTR smart00345
helix_turn_helix gluconate operon transcriptional repressor;
65-123 7.46e-08

helix_turn_helix gluconate operon transcriptional repressor;


Pssm-ID: 197669 [Multi-domain]  Cd Length: 60  Bit Score: 48.34  E-value: 7.46e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 811922143    65 VAGHLRAAIMSGALRSGTfiRLD---ETAAELGVSVTPVREALLKLRGEGMVGLEPHRGHVV 123
Cdd:smart00345   1 VAERLREDIVSGELRPGD--KLPserELAAQLGVSRTTVREALSRLEAEGLVQRRPGSGTFV 60
 
Name Accession Description Interval E-value
GntR COG1802
DNA-binding transcriptional regulator, GntR family [Transcription];
52-268 5.70e-40

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441407 [Multi-domain]  Cd Length: 222  Bit Score: 138.13  E-value: 5.70e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 811922143  52 SQLPLRRAQLSDEVAGHLRAAIMSGALRSGTFIRLDETAAELGVSVTPVREALLKLRGEGMVGLEPHRGHVVLPLTRQDI 131
Cdd:COG1802    3 SPSPLRRESLAEQVYEALREAILSGELPPGERLSEAELAERLGVSRTPVREALRRLEAEGLVEIRPNRGARVAPLSPEEI 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 811922143 132 DDIFWLQATIAQELATSATAHITDVEIDELDRINNALAGAIGSGDAKTIASIEFAFHRVFNKASRRIKLA------WFLL 205
Cdd:COG1802   83 RELYEVRAALEGLAARLAAERATPADLARLRALLEELEAAAAAGDVAAYLELDREFHRALVEAAGNPRLAellrrlRARL 162

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 811922143 206 NAARYMpaqvFAADPRWGADAVNSHRQLIAALRRRDTAAVIEHTVWQFTDGARRLTEALAETE 268
Cdd:COG1802  163 RRYRRL----SLRSPGRLEESLAEHRAILDALEAGDAEAAAAALRAHLERARERLLEALAAAA 221
FadR COG2186
DNA-binding transcriptional regulator, FadR family [Transcription];
55-268 1.71e-20

DNA-binding transcriptional regulator, FadR family [Transcription];


Pssm-ID: 441789 [Multi-domain]  Cd Length: 232  Bit Score: 87.30  E-value: 1.71e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 811922143  55 PLRRAQLSDEVAGHLRAAIMSGALRSGTfiRLD---ETAAELGVSVTPVREALLKLRGEGMVglEPHRGH---------- 121
Cdd:COG2186    2 PIRRRSLAEQVAEQLRELILSGELKPGD--RLPserELAEQLGVSRTTVREALRALEALGLV--EVRQGGgtfvrepspw 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 811922143 122 -------VVLPLTRQDIDDIFWLQATIAQELATSATAHITDVEIDELDRINNALAGAIGSGDAKTIAsiEFAFHRVFNKA 194
Cdd:COG2186   78 alldplaLLLALDDASLRDLLEARLALEPEAARLAAERATDEDLARLEAALAEMEAAADDGEAFAEA--DLAFHRAIAEA 155

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 811922143 195 S--RRIKLAWFLLNAARYMPAQVFAADPRWGADAVNSHRQLIAALRRRDTAAVIEHTVWQFTDGARRLTEALAETE 268
Cdd:COG2186  156 SgnPLLALLLESLRELLRRSVRLTLRSPEARERSLAEHRAILDAIRAGDPEAARAAMRAHLEAVRERLREALAERA 231
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 61-123 4.66e-11

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 57.07  E-value: 4.66e-11
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 811922143  61 LSDEVAGHLRAAIMSGALRSGTfiRL---DETAAELGVSVTPVREALLKLRGEGMVGLEPHRGHVV 123
Cdd:cd07377    2 LYEQIADQLREAILSGELKPGD--RLpseRELAEELGVSRTTVREALRELEAEGLVERRPGRGTFV 65
GntR pfam00392
Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the ...
 61-123 1.61e-10

Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcription factors. At the C-terminus there is usually an effector-binding/oligomerization domain. The GntR-like proteins include the following sub-families: MocR, YtrR, FadR, AraR, HutC and PlmA, DevA, DasR. Many of these proteins have been shown experimentally to be autoregulatory, enabling the prediction of operator sites and the discovery of cis/trans relationships. The DasR regulator has been shown to be a global regulator of primary metabolism and development in Streptomyces coelicolor.


Pssm-ID: 306822 [Multi-domain]  Cd Length: 64  Bit Score: 55.70  E-value: 1.61e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 811922143   61 LSDEVAGHLRAAIMSGALRSGTFI-RLDETAAELGVSVTPVREALLKLRGEGMVGLEPHRGHVV 123
Cdd:pfam00392   1 LYEQVYARLREDILSGRLRPGDKLpSERELAAEFGVSRTTVREALRRLEAEGLVERRQGRGTFV 64
FCD pfam07729
FCD domain; This domain is the C-terminal ligand binding domain of many members of the GntR ...
 133-245 1.01e-09

FCD domain; This domain is the C-terminal ligand binding domain of many members of the GntR family. This domain binds to a range of effector molecules, including Lactate, Zn(II), Ni(II), Ca(II), Mg(II), citrate, sugar acids, sialic acid and N-acetylglucosamine-6-P, that regulate the transcription of genes through the action of the N-terminal DNA-binding domain pfam00392 (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043). This domain is found in Swiss:P45427 and Swiss:P31460 that are regulators of sugar biosynthesis operons. It is also in the known structure of FadR where it binds to acyl-coA, the domain is alpha helical. This family has been named as FCD for (FadR C-terminal Domain).


Pssm-ID: 429623 [Multi-domain]  Cd Length: 121  Bit Score: 55.07  E-value: 1.01e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 811922143  133 DIFWLQATIAQELATSATAHITDVEIDELDRINNALAGAIGSGDAKTIASIEFAFHRVFNKASRRIKLAWFL--LNAARY 210
Cdd:pfam07729   1 ELYELRAALEPLAARLAAERATDEDLAELEALLEALEAAADAGDLEAFAEADREFHLALAEAAGNPVLARMLesLWDRLR 80

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 811922143  211 MPAQVFAADPRWGADAVNSHRQLIAALRRRDTAAV 245
Cdd:pfam07729  81 RLRRLLLSSPGRLRASLEEHRAILDAIRARDPEAA 115
PRK11414 PRK11414
GntR family transcriptional regulator;
61-244 6.21e-09

GntR family transcriptional regulator;


Pssm-ID: 183126 [Multi-domain]  Cd Length: 221  Bit Score: 54.88  E-value: 6.21e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 811922143  61 LSDEVAGHLRAAIMSGALRSGTFIRLDETAAELGVSVTPVREALLKLRGEGMVGLEPHRGHVVLPLTRQDIDDIFWLQAT 140
Cdd:PRK11414  12 LTLQVENDLKHQLSIGALKPGARLITKNLAEQLGMSITPVREALLRLVSVNALSVAPAQAFTVPEVSKRQLDEINRIRYE 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 811922143 141 IAQELATSATAHITDVEIDELDRINNALAGAIGSGDAKTIASIEFAFH-RVFNKASRRIKLAWFLLNAARYMPAQVF--- 216
Cdd:PRK11414  92 LELMAVALAVENLTPQDLAELQELLEKLQQAQEKGDMEQIINANRLFRlAIYHRSNMPILCEMIEQLWVRMGPSLHYlye 171

                        170       180
                 ....*....|....*....|....*...
gi 811922143 217 AADPRWGADAVNSHRQLIAALRRRDTAA 244
Cdd:PRK11414 172 AINPAELREHIENYRLLLAALKAKDKEG 199
HTH_GNTR smart00345
helix_turn_helix gluconate operon transcriptional repressor;
65-123 7.46e-08

helix_turn_helix gluconate operon transcriptional repressor;


Pssm-ID: 197669 [Multi-domain]  Cd Length: 60  Bit Score: 48.34  E-value: 7.46e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 811922143    65 VAGHLRAAIMSGALRSGTfiRLD---ETAAELGVSVTPVREALLKLRGEGMVGLEPHRGHVV 123
Cdd:smart00345   1 VAERLREDIVSGELRPGD--KLPserELAAQLGVSRTTVREALSRLEAEGLVQRRPGSGTFV 60
FCD smart00895
This entry represents the C-terminal ligand binding domain of many members of the GntR family; ...
 133-244 4.23e-07

This entry represents the C-terminal ligand binding domain of many members of the GntR family; This domain probably binds to a range of effector molecules that regulate the transcription of genes through the action of the N-terminal DNA-binding domain. This domain is found in and that are regulators of sugar biosynthesis operons. Many bacterial transcription regulation proteins bind DNA through a helix-turn-helix (HTH) motif, which can be classified into subfamilies on the basis of sequence similarities. The HTH GntR family has many members distributed among diverse bacterial groups that regulate various biological processes. It was named GntR after the Bacillus subtilis repressor of the gluconate operon. In general, these proteins contain a DNA-binding HTH domain at the N terminus, and an effector binding or oligomerisation domain at the C terminus. The winged-helix DNA-binding domain is well conserved in structure for the whole of the GntR family, and is similar in structure to other transcriptional regulator families. The C-terminal effector-binding and oligomerisation domains are more variable and are consequently used to define the subfamilies. Based on the sequence and structure of the C-terminal domains, the GtnR family can be divided into four major groups, as represented by FadR, HutC, MocR and YtrA, as well as some minor groups such as those represented by AraR and PlmA.


Pssm-ID: 214892 [Multi-domain]  Cd Length: 123  Bit Score: 47.74  E-value: 4.23e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 811922143   133 DIFWLQATIAQELATSATAHITDVEIDELDRINNALAGAIGSGDA-KTIASIEFAFHRVFNKASRRIKLAWFLLNAARYM 211
Cdd:smart00895   1 ELYEVRRALEPLAARLAAERATDEDLAALEALLDAMEAAAAAGDDlEEFAELDREFHRALAEAAGNPVLLELLESLRARL 80

                           90       100       110
                   ....*....|....*....|....*....|...
gi 811922143   212 pAQVFAADPRWGADAVNSHRQLIAALRRRDTAA 244
Cdd:smart00895  81 -RRLRRLSLEAARRALDEHRAILDAIRARDAEA 112
PRK09990 PRK09990
DNA-binding transcriptional regulator GlcC; Provisional
 57-218 6.13e-06

DNA-binding transcriptional regulator GlcC; Provisional


Pssm-ID: 182186 [Multi-domain]  Cd Length: 251  Bit Score: 46.30  E-value: 6.13e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 811922143  57 RRAQLSDEVAGHLRAAIMSGALRSGTFI----RLDEtaaELGVSVTPVREALLKLRGEGMVGLEPHRGHVVLPLTRQD-- 130
Cdd:PRK09990   4 ERRPIADVVAERIERLIVDGVLKVGQALpserRLCE---KLGFSRSALREGLTVLRGRGIIETAQGRGSFVARLNRVQda 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 811922143 131 -------------IDDIFWLQATIAQELATSATAHITDVEIDELDRINNALAGAIGSG---DAKTIASIEFAFHRVFNKA 194
Cdd:PRK09990  81 splmhlfssqprtLYDLLEVRALLEGESARLAALRGTQADFVLITRRYEEMLAAHENNkeiDPIEHARLDHAFHLAICEA 160

                        170       180
                 ....*....|....*....|....
gi 811922143 195 SRRIKLAWFLLNAARYMPAQVFAA 218
Cdd:PRK09990 161 SHNPVLVHTLQSLTDLMLSSVFAS 184
PRK10421 PRK10421
DNA-binding transcriptional repressor LldR; Provisional
 61-200 1.15e-04

DNA-binding transcriptional repressor LldR; Provisional


Pssm-ID: 236690 [Multi-domain]  Cd Length: 253  Bit Score: 42.45  E-value: 1.15e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 811922143  61 LSDEVAGHLRAAIMSGALRSGtfIRLD---ETAAELGVSVTPVREALLKLRGEGMvgLEPHRG---------------HV 122
Cdd:PRK10421   3 LSDEVADRVRALIEEKNLEAG--MKLPaerQLAMQLGVSRNSLREALAKLVSEGV--LLSRRGggtfirwrhetwseqNI 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 811922143 123 VLP---LTRQDID---DIfwLQATIAQELATSATAHITDVEIDElDRINNALaGAIGSGDAKTIASIEFAFHRVFNKASR 196
Cdd:PRK10421  79 VQPlktLMADDPDysfDI--LEARHAIEASTAWHAAMRATPGDK-EKIQLCF-EATLSEDPDLASQADVRFHLAIAEASH 154


                 ....
gi 811922143 197 RIKL 200
Cdd:PRK10421 155 NVVL 158
ARO8 COG1167
DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain ...
 50-240 3.68e-04

DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain [Transcription, Amino acid transport and metabolism]; DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain is part of the Pathway/BioSystem: Lysine biosynthesis


Pssm-ID: 440781 [Multi-domain]  Cd Length: 471  Bit Score: 41.35  E-value: 3.68e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 811922143  50 PRSQLPLRRAqlsdeVAGHLRAAIMSGALRSGTfiRLD---ETAAELGVSVTPVREALLKLRGEGMVGLEPHRGHVVLPL 126
Cdd:COG1167    7 RDSSGPLYLQ-----LADALREAILSGRLPPGD--RLPssrELAAQLGVSRSTVVRAYEELEAEGLIESRPGSGTFVAAR 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 811922143 127 TRQdiddifwlqatiaqelATSATAHITDVEIDELDRINNALAGAI--GSGdaktIASIEFAFHRVFNKASRRiklawfl 204
Cdd:COG1167   80 LPA----------------PAPAPRAAAAVAAPALRRLLEAAPGVIdlGSG----APDPDLFPLAALRRALRR------- 132

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 811922143 205 lnAARYMPAQVFAADPRWGADAvnsHRQLIAA-LRRR 240
Cdd:COG1167  133 --ALRRLPPALLGYGDPQGLPE---LREAIARyLARR 164
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
64-120 8.40e-04

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 39.85  E-value: 8.40e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 811922143  64 EVAGHLRAAIMSGALRSGTfiRL---DETAAELGVSVTPVREALLKLRGEGMVglEPHRG 120
Cdd:COG2188    9 QIADALRERIESGELPPGD--RLpseRELAEEFGVSRMTVRKALDELVEEGLL--ERRQG 64
PRK11534 PRK11534
DNA-binding transcriptional regulator CsiR; Provisional
 69-175 1.85e-03

DNA-binding transcriptional regulator CsiR; Provisional


Pssm-ID: 183181 [Multi-domain]  Cd Length: 224  Bit Score: 38.72  E-value: 1.85e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 811922143  69 LRAAIMSGALRSGTFIRLDETAAELGVSVTPVREALLKLRGEGMVGLEPHRGHVVLPLTRQDIDDIFWLQATI------- 141
Cdd:PRK11534  16 LKNDIIRGNFQPDEKLRMSLLTSRYALGVGPLREALSQLVAERLVTVVNQKGYRVASMSEQELLDIFDARANMeamlvsl 95

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 811922143 142 ----------------AQELATSATAHITDVEIDELDRINNALAGAIGSG 175
Cdd:PRK11534  96 aiarggdeweadvlakAHLLSKLEACDASEKMLDEWDLRHQAFHTAIVAG 145
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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