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Conserved domains on  [gi|892137798|emb|CMY13815|]
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DNA-binding response regulator [Streptococcus pneumoniae]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
resp_reg_YycF super family cl45866
response regulator YycF;
2-232 1.90e-128

response regulator YycF;


The actual alignment was detected with superfamily member NF040534:

Pssm-ID: 439744 [Multi-domain]  Cd Length: 231  Bit Score: 362.12  E-value: 1.90e-128
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798   2 KKILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRKTSSVPILMLSAK 81
Cdd:NF040534   1 KKILVVDDEKPIADILEFNLKKEGYEVFCAYDGNEALELVEEEVPDLVLLDIMLPGRDGMEVCREVRKKYDMPIIMLTAK 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798  82 DSEFDKVIGLELGADDYVTKPFSNRELQARVKALLRRSQPMPVDGQEADSkpQPIQIGDLEIVPDAYVAKKYGEELDLTH 161
Cdd:NF040534  81 DSEIDKVLGLELGADDYVTKPFSTRELIARVKANLRRHQQQNTEEEEEEN--NEIVIGSLTIHPDAYTVKKRGETIELTH 158

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 892137798 162 REFELLYHLASHTGQVITREHLLETVWGYDYFGDVRTVDVTVRRLREKIEDTPSRPEYILTRRGVGYYMRN 232
Cdd:NF040534 159 REFELLHYLAKHIGQVMTREHLLQTVWGYDYFGDVRTVDVTVRRLREKIEDNPSHPEWIVTRRGVGYYLRN 229
 
Name Accession Description Interval E-value
resp_reg_YycF NF040534
response regulator YycF;
2-232 1.90e-128

response regulator YycF;


Pssm-ID: 439744 [Multi-domain]  Cd Length: 231  Bit Score: 362.12  E-value: 1.90e-128
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798   2 KKILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRKTSSVPILMLSAK 81
Cdd:NF040534   1 KKILVVDDEKPIADILEFNLKKEGYEVFCAYDGNEALELVEEEVPDLVLLDIMLPGRDGMEVCREVRKKYDMPIIMLTAK 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798  82 DSEFDKVIGLELGADDYVTKPFSNRELQARVKALLRRSQPMPVDGQEADSkpQPIQIGDLEIVPDAYVAKKYGEELDLTH 161
Cdd:NF040534  81 DSEIDKVLGLELGADDYVTKPFSTRELIARVKANLRRHQQQNTEEEEEEN--NEIVIGSLTIHPDAYTVKKRGETIELTH 158

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 892137798 162 REFELLYHLASHTGQVITREHLLETVWGYDYFGDVRTVDVTVRRLREKIEDTPSRPEYILTRRGVGYYMRN 232
Cdd:NF040534 159 REFELLHYLAKHIGQVMTREHLLQTVWGYDYFGDVRTVDVTVRRLREKIEDNPSHPEWIVTRRGVGYYLRN 229
MtrAB_MtrA NF040689
MtrAB system response regulator MtrA;
4-228 2.27e-88

MtrAB system response regulator MtrA;


Pssm-ID: 468653 [Multi-domain]  Cd Length: 219  Bit Score: 260.19  E-value: 2.27e-88
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798   4 ILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRKTSSVPILMLSAKDS 83
Cdd:NF040689   1 ILVVDDDPALAEMLGIVLRAEGFETVFCADGAEAVEAFREVRPDLVLLDLMLPGMDGIEVCRQIRAESGVPIIMLTAKSD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798  84 EFDKVIGLELGADDYVTKPFSNRELQARVKALLRRSQpmpvdgqeaDSKPQPIQIGDLEIVPDAYVAKKYGEELDLTHRE 163
Cdd:NF040689  81 TVDVVRGLEAGADDYVVKPFKPKELVARIRARLRRSE---------DEESEVLRIGDLTIDVAGHEVTRGGEEIPLTPLE 151

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 892137798 164 FELLYHLASHTGQVITREHLLETVWGYDYFGDVRTVDVTVRRLREKIEDTPSRPEYILTRRGVGY 228
Cdd:NF040689 152 FDLLVALARKPGQVFSREELLEQVWGYRHAADTRLVNVHVQRLRAKIERDPENPEIVVTVRGVGY 216
OmpR COG0745
DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain ...
 1-222 4.86e-87

DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain [Signal transduction mechanisms, Transcription];


Pssm-ID: 440508 [Multi-domain]  Cd Length: 204  Bit Score: 256.42  E-value: 4.86e-87
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798   1 MKKILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRKTSS-VPILMLS 79
Cdd:COG0745    1 MPRILVVEDDPDIRELLADALEREGYEVDTAADGEEALELLEEERPDLILLDLMLPGMDGLEVCRRLRARPSdIPIIMLT 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798  80 AKDSEFDKVIGLELGADDYVTKPFSNRELQARVKALLRRSQpmpvdgqeadskPQPIQIGDLeIVPDAYVAKKYGEELDL 159
Cdd:COG0745   81 ARDDEEDRVRGLEAGADDYLTKPFDPEELLARIRALLRRRA------------AEVLRVGDL-LDLAAREVTRDGEPVEL 147

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 892137798 160 THREFELLYHLASHTGQVITREHLLETVWGYDYfGDVRTVDVTVRRLREKIEDtpsrpEYILT 222
Cdd:COG0745  148 TPKEFRLLELLMRNPGRVVSREQLLEEVWGYDY-GDDRTVDVHISRLRKKLED-----DLIET 204
PhoB TIGR02154
phosphate regulon transcriptional regulatory protein PhoB; PhoB is a DNA-binding response ...
 2-228 1.71e-78

phosphate regulon transcriptional regulatory protein PhoB; PhoB is a DNA-binding response regulator protein acting with PhoR in a 2-component system responding to phosphate ion. PhoB acts as a positive regulator of gene expression for phosphate-related genes such as phoA, phoS, phoE and ugpAB as well as itself. It is often found proximal to genes for the high-affinity phosphate ABC transporter (pstSCAB; GenProp0190) and presumably regulates these as well. [Regulatory functions, DNA interactions, Signal transduction, Two-component systems]


Pssm-ID: 131209 [Multi-domain]  Cd Length: 226  Bit Score: 235.30  E-value: 1.71e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798    2 KKILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRK---TSSVPILML 78
Cdd:TIGR02154   3 RRILVVEDEPAIRELIAYNLEKAGYDVVEAGDGDEALTLINERGPDLILLDWMLPGTSGIELCRRLRRrpeTRAIPIIML 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798   79 SAKDSEFDKVIGLELGADDYVTKPFSNRELQARVKALLRRSQPMPVDGqeadskpqPIQIGDLEIVPDAYVAKKYGEELD 158
Cdd:TIGR02154  83 TARGEEEDRVRGLETGADDYITKPFSPRELLARIKAVLRRIRPQLSDE--------VIEVGDLSLDPVAHRVFRGGQPLS 154

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798  159 LTHREFELLYHLASHTGQVITREHLLETVWGYDYFGDVRTVDVTVRRLREKIEDTpSRPEYILTRRGVGY 228
Cdd:TIGR02154 155 LGPTEFRLLHFFMTHPERVYSREQLLDRVWGRDVYVEERTVDVHIRRLRKALNPF-GLEDPVQTVRGAGY 223
orf27 CHL00148
Ycf27; Reviewed
 2-228 3.11e-77

Ycf27; Reviewed


Pssm-ID: 214376 [Multi-domain]  Cd Length: 240  Bit Score: 232.68  E-value: 3.11e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798   2 KKILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRKTSSVPILMLSAK 81
Cdd:CHL00148   7 EKILVVDDEAYIRKILETRLSIIGYEVITASDGEEALKLFRKEQPDLVILDVMMPKLDGYGVCQEIRKESDVPIIMLTAL 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798  82 DSEFDKVIGLELGADDYVTKPFSNRELQARVKALLRRSQPMPVDGQEADSkpQPIQIGDLEIVPDAYVAKKYGEELDLTH 161
Cdd:CHL00148  87 GDVSDRITGLELGADDYVVKPFSPKELEARIRSVLRRTNKKSFSSKIPNS--SIIRIGFLKIDLNKKQVYKNNERIRLTG 164

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 892137798 162 REFELLYHLASHTGQVITREHLLETVWGYDY--FGDVRTVDVTVRRLREKIEDTPSRPEYILTRRGVGY 228
Cdd:CHL00148 165 MEFSLLELLISKSGEIFSRATILKEVWGYTPerHIDTRVVDVHISRLRAKLEDDPSNPDLILTARGTGY 233
REC_OmpR_YycF-like cd17614
phosphoacceptor receiver (REC) domain of YrcF-like OmpR family response regulators; YycF ...
 4-118 7.29e-72

phosphoacceptor receiver (REC) domain of YrcF-like OmpR family response regulators; YycF appears to play an important role in cell wall integrity in a wide range of gram-positive bacteria, and may also modulate cell membrane integrity. It functions as part of a phosphotransfer system that ultimately controls the levels of competence within the bacteria. YycF belongs to the OmpR family of response regulators, which are characterized by a REC domain and a winged helix-turn-helix effector domain involved in DNA binding. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381130 [Multi-domain]  Cd Length: 115  Bit Score: 214.59  E-value: 7.29e-72
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798   4 ILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRKTSSVPILMLSAKDS 83
Cdd:cd17614    1 ILVVDDEKPISDILKFNLTKEGYEVVTAYDGREALEKVEEEQPDLILLDLMLPEKDGLEVCREVRKTSNVPIIMLTAKDS 80

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 892137798  84 EFDKVIGLELGADDYVTKPFSNRELQARVKALLRR 118
Cdd:cd17614   81 EVDKVLGLELGADDYVTKPFSNRELLARVKANLRR 115
Response_reg pfam00072
Response regulator receiver domain; This domain receives the signal from the sensor partner in ...
 4-113 6.73e-35

Response regulator receiver domain; This domain receives the signal from the sensor partner in bacterial two-component systems. It is usually found N-terminal to a DNA binding effector domain.


Pssm-ID: 395025 [Multi-domain]  Cd Length: 111  Bit Score: 120.33  E-value: 6.73e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798    4 ILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRKTS-SVPILMLSAKD 82
Cdd:pfam00072   1 VLIVDDDPLIRELLRQLLEKEGYVVAEADDGKEALELLKEERPDLILLDINMPGMDGLELLKRIRRRDpTTPVIILTAHG 80

                          90       100       110
                  ....*....|....*....|....*....|.
gi 892137798   83 SEFDKVIGLELGADDYVTKPFSNRELQARVK 113
Cdd:pfam00072  81 DEDDAVEALEAGADDFLSKPFDPDELLAAIR 111
Trans_reg_C smart00862
Transcriptional regulatory protein, C terminal; This domain is almost always found associated ...
 154-230 1.37e-30

Transcriptional regulatory protein, C terminal; This domain is almost always found associated with the response regulator receiver domain. It may play a role in DNA binding.


Pssm-ID: 214866 [Multi-domain]  Cd Length: 76  Bit Score: 108.02  E-value: 1.37e-30
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 892137798   154 GEELDLTHREFELLYHLASHTGQVITREHLLETVWGYDYFGDVRTVDVTVRRLREKIEDtPSRPEYILTRRGVGYYM 230
Cdd:smart00862   1 GEPIKLTPKEFRLLELLLRNPGRVVSREELLEAVWGDDEDVDDNTLDVHISRLRKKLED-DGDPRLIETVRGVGYRL 76
 
Name Accession Description Interval E-value
resp_reg_YycF NF040534
response regulator YycF;
2-232 1.90e-128

response regulator YycF;


Pssm-ID: 439744 [Multi-domain]  Cd Length: 231  Bit Score: 362.12  E-value: 1.90e-128
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798   2 KKILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRKTSSVPILMLSAK 81
Cdd:NF040534   1 KKILVVDDEKPIADILEFNLKKEGYEVFCAYDGNEALELVEEEVPDLVLLDIMLPGRDGMEVCREVRKKYDMPIIMLTAK 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798  82 DSEFDKVIGLELGADDYVTKPFSNRELQARVKALLRRSQPMPVDGQEADSkpQPIQIGDLEIVPDAYVAKKYGEELDLTH 161
Cdd:NF040534  81 DSEIDKVLGLELGADDYVTKPFSTRELIARVKANLRRHQQQNTEEEEEEN--NEIVIGSLTIHPDAYTVKKRGETIELTH 158

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 892137798 162 REFELLYHLASHTGQVITREHLLETVWGYDYFGDVRTVDVTVRRLREKIEDTPSRPEYILTRRGVGYYMRN 232
Cdd:NF040534 159 REFELLHYLAKHIGQVMTREHLLQTVWGYDYFGDVRTVDVTVRRLREKIEDNPSHPEWIVTRRGVGYYLRN 229
MtrAB_MtrA NF040689
MtrAB system response regulator MtrA;
4-228 2.27e-88

MtrAB system response regulator MtrA;


Pssm-ID: 468653 [Multi-domain]  Cd Length: 219  Bit Score: 260.19  E-value: 2.27e-88
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798   4 ILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRKTSSVPILMLSAKDS 83
Cdd:NF040689   1 ILVVDDDPALAEMLGIVLRAEGFETVFCADGAEAVEAFREVRPDLVLLDLMLPGMDGIEVCRQIRAESGVPIIMLTAKSD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798  84 EFDKVIGLELGADDYVTKPFSNRELQARVKALLRRSQpmpvdgqeaDSKPQPIQIGDLEIVPDAYVAKKYGEELDLTHRE 163
Cdd:NF040689  81 TVDVVRGLEAGADDYVVKPFKPKELVARIRARLRRSE---------DEESEVLRIGDLTIDVAGHEVTRGGEEIPLTPLE 151

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 892137798 164 FELLYHLASHTGQVITREHLLETVWGYDYFGDVRTVDVTVRRLREKIEDTPSRPEYILTRRGVGY 228
Cdd:NF040689 152 FDLLVALARKPGQVFSREELLEQVWGYRHAADTRLVNVHVQRLRAKIERDPENPEIVVTVRGVGY 216
OmpR COG0745
DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain ...
 1-222 4.86e-87

DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain [Signal transduction mechanisms, Transcription];


Pssm-ID: 440508 [Multi-domain]  Cd Length: 204  Bit Score: 256.42  E-value: 4.86e-87
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798   1 MKKILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRKTSS-VPILMLS 79
Cdd:COG0745    1 MPRILVVEDDPDIRELLADALEREGYEVDTAADGEEALELLEEERPDLILLDLMLPGMDGLEVCRRLRARPSdIPIIMLT 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798  80 AKDSEFDKVIGLELGADDYVTKPFSNRELQARVKALLRRSQpmpvdgqeadskPQPIQIGDLeIVPDAYVAKKYGEELDL 159
Cdd:COG0745   81 ARDDEEDRVRGLEAGADDYLTKPFDPEELLARIRALLRRRA------------AEVLRVGDL-LDLAAREVTRDGEPVEL 147

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 892137798 160 THREFELLYHLASHTGQVITREHLLETVWGYDYfGDVRTVDVTVRRLREKIEDtpsrpEYILT 222
Cdd:COG0745  148 TPKEFRLLELLMRNPGRVVSREQLLEEVWGYDY-GDDRTVDVHISRLRKKLED-----DLIET 204
PhoB TIGR02154
phosphate regulon transcriptional regulatory protein PhoB; PhoB is a DNA-binding response ...
 2-228 1.71e-78

phosphate regulon transcriptional regulatory protein PhoB; PhoB is a DNA-binding response regulator protein acting with PhoR in a 2-component system responding to phosphate ion. PhoB acts as a positive regulator of gene expression for phosphate-related genes such as phoA, phoS, phoE and ugpAB as well as itself. It is often found proximal to genes for the high-affinity phosphate ABC transporter (pstSCAB; GenProp0190) and presumably regulates these as well. [Regulatory functions, DNA interactions, Signal transduction, Two-component systems]


Pssm-ID: 131209 [Multi-domain]  Cd Length: 226  Bit Score: 235.30  E-value: 1.71e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798    2 KKILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRK---TSSVPILML 78
Cdd:TIGR02154   3 RRILVVEDEPAIRELIAYNLEKAGYDVVEAGDGDEALTLINERGPDLILLDWMLPGTSGIELCRRLRRrpeTRAIPIIML 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798   79 SAKDSEFDKVIGLELGADDYVTKPFSNRELQARVKALLRRSQPMPVDGqeadskpqPIQIGDLEIVPDAYVAKKYGEELD 158
Cdd:TIGR02154  83 TARGEEEDRVRGLETGADDYITKPFSPRELLARIKAVLRRIRPQLSDE--------VIEVGDLSLDPVAHRVFRGGQPLS 154

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798  159 LTHREFELLYHLASHTGQVITREHLLETVWGYDYFGDVRTVDVTVRRLREKIEDTpSRPEYILTRRGVGY 228
Cdd:TIGR02154 155 LGPTEFRLLHFFMTHPERVYSREQLLDRVWGRDVYVEERTVDVHIRRLRKALNPF-GLEDPVQTVRGAGY 223
orf27 CHL00148
Ycf27; Reviewed
 2-228 3.11e-77

Ycf27; Reviewed


Pssm-ID: 214376 [Multi-domain]  Cd Length: 240  Bit Score: 232.68  E-value: 3.11e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798   2 KKILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRKTSSVPILMLSAK 81
Cdd:CHL00148   7 EKILVVDDEAYIRKILETRLSIIGYEVITASDGEEALKLFRKEQPDLVILDVMMPKLDGYGVCQEIRKESDVPIIMLTAL 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798  82 DSEFDKVIGLELGADDYVTKPFSNRELQARVKALLRRSQPMPVDGQEADSkpQPIQIGDLEIVPDAYVAKKYGEELDLTH 161
Cdd:CHL00148  87 GDVSDRITGLELGADDYVVKPFSPKELEARIRSVLRRTNKKSFSSKIPNS--SIIRIGFLKIDLNKKQVYKNNERIRLTG 164

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 892137798 162 REFELLYHLASHTGQVITREHLLETVWGYDY--FGDVRTVDVTVRRLREKIEDTPSRPEYILTRRGVGY 228
Cdd:CHL00148 165 MEFSLLELLISKSGEIFSRATILKEVWGYTPerHIDTRVVDVHISRLRAKLEDDPSNPDLILTARGTGY 233
REC_OmpR_YycF-like cd17614
phosphoacceptor receiver (REC) domain of YrcF-like OmpR family response regulators; YycF ...
 4-118 7.29e-72

phosphoacceptor receiver (REC) domain of YrcF-like OmpR family response regulators; YycF appears to play an important role in cell wall integrity in a wide range of gram-positive bacteria, and may also modulate cell membrane integrity. It functions as part of a phosphotransfer system that ultimately controls the levels of competence within the bacteria. YycF belongs to the OmpR family of response regulators, which are characterized by a REC domain and a winged helix-turn-helix effector domain involved in DNA binding. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381130 [Multi-domain]  Cd Length: 115  Bit Score: 214.59  E-value: 7.29e-72
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798   4 ILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRKTSSVPILMLSAKDS 83
Cdd:cd17614    1 ILVVDDEKPISDILKFNLTKEGYEVVTAYDGREALEKVEEEQPDLILLDLMLPEKDGLEVCREVRKTSNVPIIMLTAKDS 80

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 892137798  84 EFDKVIGLELGADDYVTKPFSNRELQARVKALLRR 118
Cdd:cd17614   81 EVDKVLGLELGADDYVTKPFSNRELLARVKANLRR 115
PRK11083 PRK11083
DNA-binding response regulator CreB; Provisional
 1-228 6.30e-61

DNA-binding response regulator CreB; Provisional


Pssm-ID: 236838 [Multi-domain]  Cd Length: 228  Bit Score: 190.94  E-value: 6.30e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798   1 MKKILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRK-TSSVPILMLS 79
Cdd:PRK11083   3 QPTILLVEDEQAIADTLVYALQSEGFTVEWFERGLPALDKLRQQPPDLVILDVGLPDISGFELCRQLLAfHPALPVIFLT 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798  80 AKDSEFDKVIGLELGADDYVTKPFSNRELQARVKALLRRSQPMpvdgqeadSKPQP-IQIGDLEIVPDAYVAKKYGEELD 158
Cdd:PRK11083  83 ARSDEVDRLVGLEIGADDYVAKPFSPREVAARVRTILRRVKKF--------AAPSPvIRIGHFELDEPAARISYFGTPLT 154

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 892137798 159 LTHREFELLYHLASHTGQVITREHLLETVW-----GYDyfgdvRTVDVTVRRLREKIEDTPSRPEYILTRRGVGY 228
Cdd:PRK11083 155 LTRYEFLLLKTLLLSPGRVFSRQQLMDIVWedaqdSYD-----RTVDTHIKTLRAKLRAINPDLSPINTHRGMGY 224
REC_OmpR_BsPhoP-like cd19937
phosphoacceptor receiver (REC) domain of BsPhoP-like OmpR family response regulators; Bacillus ...
 5-117 1.45e-60

phosphoacceptor receiver (REC) domain of BsPhoP-like OmpR family response regulators; Bacillus subtilis PhoP (BsPhoP) is part of the PhoPR two-component system that participates in a signal transduction network that controls adaptation of the bacteria to phosphate deficiency by regulating (activating or repressing) genes of the Pho regulon upon phosphorylation by PhoR. When activated, PhoPR directs expression of phosphate scavenging enzymes, lowers synthesis of the phosphate-rich wall teichoic acid (WTA) and initiates synthesis of teichuronic acid, a non-phosphate containing replacement anionic polymer. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381164 [Multi-domain]  Cd Length: 116  Bit Score: 185.94  E-value: 1.45e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798   5 LIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIR---KTSSVPILMLSAK 81
Cdd:cd19937    1 LVVDDEEDIVELLKYNLEKEGYEVVTAYDGEEALKRAKDEKPDLIILDLMLPGIDGLEVCRILRsdpKTSSIPIIMLTAK 80

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 892137798  82 DSEFDKVIGLELGADDYVTKPFSNRELQARVKALLR 117
Cdd:cd19937   81 GEEFDKVLGLELGADDYITKPFSPRELLARVKAVLR 116
PRK10955 PRK10955
envelope stress response regulator transcription factor CpxR;
1-230 2.70e-59

envelope stress response regulator transcription factor CpxR;


Pssm-ID: 182864 [Multi-domain]  Cd Length: 232  Bit Score: 186.93  E-value: 2.70e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798   1 MKKILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEaEQPDIIILDLMLPEIDGLEVAKTIRKTSSVPILMLSA 80
Cdd:PRK10955   1 MNKILLVDDDRELTSLLKELLEMEGFNVIVAHDGEQALDLLD-DSIDLLLLDVMMPKKNGIDTLKELRQTHQTPVIMLTA 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798  81 KDSEFDKVIGLELGADDYVTKPFSNRELQARVKALLRRSQpMPVDGQEADSKPQPIQIGDLEIVPDAYVAKKYGEELDLT 160
Cdd:PRK10955  80 RGSELDRVLGLELGADDYLPKPFNDRELVARIRAILRRSH-WSEQQQNNDNGSPTLEVDALSLNPGRQEASFDGQTLELT 158

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798 161 HREFELLYHLASHTGQVITREHLLETVWGYDYFGDVRTVDVTVRRLREKIEDTPSRPEYILTRRGVGYYM 230
Cdd:PRK10955 159 GTEFTLLYLLAQHLGQVVSREHLSQEVLGKRLTPFDRAIDMHISNLRRKLPDRKDGHPWFKTLRGRGYLM 228
ompR PRK09468
osmolarity response regulator; Provisional
 3-228 1.85e-57

osmolarity response regulator; Provisional


Pssm-ID: 181883 [Multi-domain]  Cd Length: 239  Bit Score: 182.48  E-value: 1.85e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798   3 KILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIR-KTSSVPILMLSAK 81
Cdd:PRK09468   7 KILVVDDDMRLRALLERYLTEQGFQVRSAANAEQMDRLLTRESFHLMVLDLMLPGEDGLSICRRLRsQNNPTPIIMLTAK 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798  82 DSEFDKVIGLELGADDYVTKPFSNRELQARVKALLRRsQPMPVDGQEAdSKPQPIQIGDLEIVPDAYVAKKYGEELDLTH 161
Cdd:PRK09468  87 GEEVDRIVGLEIGADDYLPKPFNPRELLARIRAVLRR-QAPELPGAPS-QEEEVIAFGKFKLNLGTRELFRGDEPMPLTT 164

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 892137798 162 REFELLYHLASHTGQVITREHLLETVWGYDYFGDVRTVDVTVRRLREKIEDTPSRPEYILTRRGVGY 228
Cdd:PRK09468 165 GEFAVLKALVSHPREPLSRDKLMNLARGREYSAMERSIDVQISRLRRLIEEDPAHPRYIQTVWGLGY 231
cztR_silR_copR TIGR01387
heavy metal response regulator; Members of this family contain a response regulator receiver ...
 4-228 1.91e-56

heavy metal response regulator; Members of this family contain a response regulator receiver domain (pfam00072) and an associated transcriptional regulatory region (pfam00486). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc. Most members encoded by genes adjacent to genes for encoding a member of the heavy metal sensor histidine kinase family (TIGRFAMs:TIGR01386), its partner in the two-component response regulator system. [Regulatory functions, DNA interactions]


Pssm-ID: 130454 [Multi-domain]  Cd Length: 218  Bit Score: 179.22  E-value: 1.91e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798    4 ILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRKTSS-VPILMLSAKD 82
Cdd:TIGR01387   1 ILVVEDEQKTAEYLQQGLSESGYVVDAASNGRDGLHLALKDDYDLIILDVMLPGMDGWQILQTLRRSGKqTPVLFLTARD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798   83 SEFDKVIGLELGADDYVTKPFSNRELQARVKALLRRSQpmpvdgqeadSKPQPI-QIGDLEIVPDAYVAKKYGEELDLTH 161
Cdd:TIGR01387  81 SVADKVKGLDLGADDYLVKPFSFSELLARVRTLLRRSH----------SLNSTVlEIADLRMDSVRHRVSRGNIRITLTR 150

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 892137798  162 REFELLYHLASHTGQVITREHLLETVWGYDYFGDVRTVDVTVRRLREKIEDtPSRPEYILTRRGVGY 228
Cdd:TIGR01387 151 KEFQLLWLLMRRTGEVLPRTVIASLVWGMNFDSDTNVVDVAIRRLRAKVDD-PFEEKLIHTIRGMGY 216
REC_OmpR cd17574
phosphoacceptor receiver (REC) domain of OmpR family response regulators; OmpR-like proteins ...
 5-102 4.24e-53

phosphoacceptor receiver (REC) domain of OmpR family response regulators; OmpR-like proteins are one of the most widespread transcriptional regulators. OmpR family members contain REC and winged helix-turn-helix (wHTH) DNA-binding output effector domain. They are involved in the control of environmental stress tolerance (such as the oxidative, osmotic and acid stress response), motility, virulence, outer membrane biogenesis and other processes. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381116 [Multi-domain]  Cd Length: 99  Bit Score: 166.43  E-value: 4.24e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798   5 LIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRKTSS-VPILMLSAKDS 83
Cdd:cd17574    1 LVVEDDEEIAELLSDYLEKEGYEVDTAADGEEALELAREEQPDLIILDVMLPGMDGFEVCRRLREKGSdIPIIMLTAKDE 80

                         90
                 ....*....|....*....
gi 892137798  84 EFDKVIGLELGADDYVTKP 102
Cdd:cd17574   81 EEDKVLGLELGADDYITKP 99
PRK10710 PRK10710
DNA-binding transcriptional regulator BaeR; Provisional
 4-228 1.60e-51

DNA-binding transcriptional regulator BaeR; Provisional


Pssm-ID: 182665 [Multi-domain]  Cd Length: 240  Bit Score: 167.17  E-value: 1.60e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798   4 ILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRKTSSVPILMLSAKDS 83
Cdd:PRK10710  13 ILIVEDEPKLGQLLIDYLQAASYATTLLSHGDEVLPYVRQTPPDLILLDLMLPGTDGLTLCREIRRFSDIPIVMVTAKIE 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798  84 EFDKVIGLELGADDYVTKPFSNRELQARVKALLRRSQPmPVDGQEADskpqpiQIGDLEIVPDAYVAKKYGEELDLTHRE 163
Cdd:PRK10710  93 EIDRLLGLEIGADDYICKPYSPREVVARVKTILRRCKP-QRELQQQD------AESPLIIDESRFQASWRGKMLDLTPAE 165

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 892137798 164 FELLYHLASHTGQVITREHLLETVwgYDYFGDV--RTVDVTVRRLREKIEDTPSRPEYILTRRGVGY 228
Cdd:PRK10710 166 FRLLKTLSHEPGKVFSREQLLNHL--YDDYRVVtdRTIDSHIKNLRRKLESLDAEQSFIRAVYGVGY 230
PRK10529 PRK10529
DNA-binding transcriptional activator KdpE; Provisional
 1-228 1.34e-49

DNA-binding transcriptional activator KdpE; Provisional


Pssm-ID: 182522 [Multi-domain]  Cd Length: 225  Bit Score: 161.90  E-value: 1.34e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798   1 MKKILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRKTSSVPILMLSA 80
Cdd:PRK10529   1 MTNVLIVEDEQAIRRFLRTALEGDGMRVFEAETLQRGLLEAATRKPDLIILDLGLPDGDGIEFIRDLRQWSAIPVIVLSA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798  81 KDSEFDKVIGLELGADDYVTKPFSNRELQARVKALLRRsqpmpvdgQEADSKPQPI-QIGDLEIVPDAYVAKKYGEELDL 159
Cdd:PRK10529  81 RSEESDKIAALDAGADDYLSKPFGIGELQARLRVALRR--------HSATPAPDPLvKFSDVTVDLAARVIHRGEEEVHL 152

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 892137798 160 THREFELLYHLASHTGQVITREHLLETVWGYDYFGDVRTVDVTVRRLREKIEDTPSRPEYILTRRGVGY 228
Cdd:PRK10529 153 TPIEFRLLAVLLNNAGKVLTQRQLLNQVWGPNAVEHSHYLRIYMGHLRQKLEQDPARPRHFITETGIGY 221
PRK11517 PRK11517
DNA-binding response regulator HprR;
3-231 1.86e-49

DNA-binding response regulator HprR;


Pssm-ID: 183172 [Multi-domain]  Cd Length: 223  Bit Score: 161.22  E-value: 1.86e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798   3 KILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRKTSSVPILMLSAKD 82
Cdd:PRK11517   2 KILLIEDNQRTQEWVTQGLSEAGYVIDAVSDGRDGLYLALKDDYALIILDIMLPGMDGWQILQTLRTAKQTPVICLTARD 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798  83 SEFDKVIGLELGADDYVTKPFSNRELQARVKALLRRSQPMpvdgqeadskPQPIQIGDLEIVPDAYVAKKYGEELDLTHR 162
Cdd:PRK11517  82 SVDDRVRGLDSGANDYLVKPFSFSELLARVRAQLRQHHAL----------NSTLEISGLRMDSVSQSVSRDNISITLTRK 151

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 892137798 163 EFELLYHLASHTGQVITREHLLETVWGYDYFGDVRTVDVTVRRLREKIEDtPSRPEYILTRRGVGYYMR 231
Cdd:PRK11517 152 EFQLLWLLASRAGEIIPRTVIASEIWGINFDSDTNTVDVAIRRLRAKVDD-PFPEKLIATIRGMGYSFV 219
PRK10161 PRK10161
phosphate response regulator transcription factor PhoB;
2-228 2.81e-49

phosphate response regulator transcription factor PhoB;


Pssm-ID: 182277 [Multi-domain]  Cd Length: 229  Bit Score: 161.04  E-value: 2.81e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798   2 KKILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRK---TSSVPILML 78
Cdd:PRK10161   3 RRILVVEDEAPIREMVCFVLEQNGFQPVEAEDYDSAVNQLNEPWPDLILLDWMLPGGSGIQFIKHLKResmTRDIPVVML 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798  79 SAKDSEFDKVIGLELGADDYVTKPFSNRELQARVKALLRRSQPMPVDgqeadskpQPIQIGDLEIVPDAYVAKKYGEELD 158
Cdd:PRK10161  83 TARGEEEDRVRGLETGADDYITKPFSPKELVARIKAVMRRISPMAVE--------EVIEMQGLSLDPTSHRVMAGEEPLE 154

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798 159 LTHREFELLYHLASHTGQVITREHLLETVWGYDYFGDVRTVDVTVRRLREKIEDTpSRPEYILTRRGVGY 228
Cdd:PRK10161 155 MGPTEFKLLHFFMTHPERVYSREQLLNHVWGTNVYVEDRTVDVHIRRLRKALEPG-GHDRMVQTVRGTGY 223
PRK10701 PRK10701
DNA-binding transcriptional regulator RstA; Provisional
 1-234 8.58e-49

DNA-binding transcriptional regulator RstA; Provisional


Pssm-ID: 236738 [Multi-domain]  Cd Length: 240  Bit Score: 160.19  E-value: 8.58e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798   1 MKKILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRKTSSVPILMLSA 80
Cdd:PRK10701   1 MNKIVFVEDDAEVGSLIAAYLAKHDIDVTVEPRGDRAEATILREQPDLVLLDIMLPGKDGMTICRDLRPKWQGPIVLLTS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798  81 KDSEFDKVIGLELGADDYVTKPFSNRELQARVKALLRRSQPMPVDGQEADSKPQP---IQIGDLEIVPDAYVAKKYGEEL 157
Cdd:PRK10701  81 LDSDMNHILALEMGACDYILKTTPPAVLLARLRLHLRQNEQATQTKGLQETSLTPykaLHFGTLTIDPVNRQVTLAGEEI 160

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 892137798 158 DLTHREFELLYHLASHTGQVITREHLLETVWGYDYFGDVRTVDVTVRRLREKIEDTPSRPEYILTRRGVGYYMRNNA 234
Cdd:PRK10701 161 SLSTADFDLLWELATHAGQIMDRDALLKNLRGVSYDGLDRSVDVAISRLRKKLLDNAAEPYRIKTVRNKGYLFAPHA 237
PRK10766 PRK10766
two-component system response regulator TorR;
2-211 4.23e-47

two-component system response regulator TorR;


Pssm-ID: 182711 [Multi-domain]  Cd Length: 221  Bit Score: 155.20  E-value: 4.23e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798   2 KKILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRKTSSVPILMLSAK 81
Cdd:PRK10766   3 YHILVVEDEPVTRARLQGYFEQEGYTVSEAASGAGMREIMQNQHVDLILLDINLPGEDGLMLTRELRSRSTVGIILVTGR 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798  82 DSEFDKVIGLELGADDYVTKPFSNRELQARVKALLRRSQPMPVDGQEADSKPQPIQIGDLEIVPDAYVAKKYGEELDLTH 161
Cdd:PRK10766  83 TDSIDRIVGLEMGADDYVTKPLELRELLVRVKNLLWRISLARQAQPHAQEEDNCYRFAGYCLNVSRRTLERNGEPIKLTK 162

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 892137798 162 REFELLYHLASHTGQVITREHLLETVWGYDYFGDVRTVDVTVRRLREKIE 211
Cdd:PRK10766 163 AEYELLVAFVTNPGQVLSRERLLRMLSHRVENPNDRTIDVLIRRLRHKLN 212
PRK11173 PRK11173
two-component response regulator; Provisional
 3-228 1.46e-46

two-component response regulator; Provisional


Pssm-ID: 183013 [Multi-domain]  Cd Length: 237  Bit Score: 154.40  E-value: 1.46e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798   3 KILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRKTSSVPILMLSAKD 82
Cdd:PRK11173   5 HILIVEDELVTRNTLKSIFEAEGYDVFEATDGAEMHQILSENDINLVIMDINLPGKNGLLLARELREQANVALMFLTGRD 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798  83 SEFDKVIGLELGADDYVTKPFSNRELQARVKALLRRSQPmpvdGQEADSKPQPIQI-----GDLEIVPDAYVAKKyGEEL 157
Cdd:PRK11173  85 NEVDKILGLEIGADDYITKPFNPRELTIRARNLLSRTMN----LGTVSEERRSVESykfngWELDINSRSLISPD-GEQY 159

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 892137798 158 DLTHREFELLYHLASHTGQVITREHLLETVWGYDYFGDVRTVDVTVRRLREKIEDTPSRPEYILTRRGVGY 228
Cdd:PRK11173 160 KLPRSEFRAMLHFCENPGKIQSRAELLKKMTGRELKPHDRTVDVTIRRIRKHFESTPDTPEIIATIHGEGY 230
REC_OmpR_DrrD-like cd17625
phosphoacceptor receiver (REC) domain of DrrD-like OmpR family response regulators; DrrD is a ...
 5-118 1.26e-44

phosphoacceptor receiver (REC) domain of DrrD-like OmpR family response regulators; DrrD is a OmpR/PhoB homolog from Thermotoga maritima whose function is not yet known. This subfamily also includes Streptococcus agalactiae transcriptional regulatory protein DltR, part of the DltS/DltR two-component system (TCS), and Pseudomonas aeruginosa transcriptional activator protein PfeR, part of the PfeR/PfeS TCS, which activates expression of the ferric enterobactin receptor. The DltS/DltR TCS regulates the expression of the dlt operon, which comprises four genes (dltA, dltB, dltC, and dltD) that catalyze the incorporation of D-alanine residues into the lipoteichoic acids. Members of this subfamily belong to the OmpR/PhoB family, which comprises of two domains, an N-terminal receiver domain and a C-terminal DNA-binding winged helix-turn-helix effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381140 [Multi-domain]  Cd Length: 115  Bit Score: 145.44  E-value: 1.26e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798   5 LIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRKTS-SVPILMLSAKDS 83
Cdd:cd17625    1 LVVEDEKDLSEAITKHLKKEGYTVDVCFDGEEGLEYALSGIYDLIILDIMLPGMDGLEVLKSLREEGiETPVLLLTALDA 80

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 892137798  84 EFDKVIGLELGADDYVTKPFSNRELQARVKALLRR 118
Cdd:cd17625   81 VEDRVKGLDLGADDYLPKPFSLAELLARIRALLRR 115
REC_OmpR_PhoB cd17618
phosphoacceptor receiver (REC) domain of PhoB response regulator from the OmpR family; The ...
 2-116 2.08e-44

phosphoacceptor receiver (REC) domain of PhoB response regulator from the OmpR family; The transcription factor PhoB is a component of the PhoR/PhoB two-component system, a key regulatory protein network that facilitates response to inorganic phosphate (Pi) starvation conditions by turning on the phosphate (pho) regulon whose products are involved in phosphorus uptake and metabolism. PhoB is a member of the OmpR family of DNA-binding response regulators that contains REC and winged helix-turn-helix (wHTH) DNA-binding output effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381133 [Multi-domain]  Cd Length: 118  Bit Score: 144.70  E-value: 2.08e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798   2 KKILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRK---TSSVPILML 78
Cdd:cd17618    1 RTILIVEDEPAIREMIAFNLERAGFDVVEAEDAESAVNLIVEPRPDLILLDWMLPGGSGIQFIRRLKRdemTRDIPIIML 80

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 892137798  79 SAKDSEFDKVIGLELGADDYVTKPFSNRELQARVKALL 116
Cdd:cd17618   81 TARGEEEDKVRGLEAGADDYITKPFSPRELVARIKAVL 118
PRK09836 PRK09836
DNA-binding transcriptional activator CusR; Provisional
 3-230 5.71e-44

DNA-binding transcriptional activator CusR; Provisional


Pssm-ID: 182102 [Multi-domain]  Cd Length: 227  Bit Score: 147.38  E-value: 5.71e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798   3 KILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRKTSS-VPILMLSAK 81
Cdd:PRK09836   2 KLLIVEDEKKTGEYLTKGLTEAGFVVDLADNGLNGYHLAMTGDYDLIILDIMLPDVNGWDIVRMLRSANKgMPILLLTAL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798  82 DSEFDKVIGLELGADDYVTKPFSNRELQARVKALLRRSQPMPVDGQeadskpqpIQIGDLEIVPDAYVAKKYGEELDLTH 161
Cdd:PRK09836  82 GTIEHRVKGLELGADDYLVKPFAFAELLARVRTLLRRGAAVIIESQ--------FQVADLMVDLVSRKVTRSGTRITLTS 153

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 892137798 162 REFELLYHLASHTGQVITREHLLETVWGYDYFGDVRTVDVTVRRLREKIeDTPSRPEYILTRRGVGYYM 230
Cdd:PRK09836 154 KEFTLLEFFLRHQGEVLPRSLIASQVWDMNFDSDTNAIDVAVKRLRGKI-DNDFEPKLIQTVRGVGYML 221
PleD COG3706
Two-component response regulator, PleD family, consists of two REC domains and a diguanylate ...
 1-117 1.92e-43

Two-component response regulator, PleD family, consists of two REC domains and a diguanylate cyclase (GGDEF) domain [Signal transduction mechanisms, Transcription];


Pssm-ID: 442920 [Multi-domain]  Cd Length: 179  Bit Score: 144.28  E-value: 1.92e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798   1 MKKILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIR---KTSSVPILM 77
Cdd:COG3706    1 PARILVVDDDPTNRKLLRRLLEAAGYEVVEAADGEEALELLQEHRPDLILLDLEMPDMDGLELCRRLRadpRTADIPIIF 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 892137798  78 LSAKDSEFDKVIGLELGADDYVTKPFSNRELQARVKALLR 117
Cdd:COG3706   81 LTALDDEEDRARALEAGADDYLTKPFDPEELLARVDLVAR 120
REC_OmpR_CpxR cd17623
phosphoacceptor receiver (REC) domain of CpxR-like OmpR family response regulators; CpxR is ...
 4-118 7.79e-42

phosphoacceptor receiver (REC) domain of CpxR-like OmpR family response regulators; CpxR is part of the CpxA/CpxR two-component regulatory system that mediates envelope stress responses that is key for virulence and antibiotic resistance in several Gram negative pathogens. CpxR is a transcription factor/response regulator that controls the expression of numerous genes, including those of the classical porins OmpF and OmpC. It belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381138 [Multi-domain]  Cd Length: 115  Bit Score: 138.21  E-value: 7.79e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798   4 ILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRKTSSVPILMLSAKDS 83
Cdd:cd17623    1 ILLIDDDRELTELLTEYLEMEGFNVRAAHDGEQGLAALLEGSPDLVVLDVMLPKMNGLDVLKELRKTSQVPVLMLTARGD 80

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 892137798  84 EFDKVIGLELGADDYVTKPFSNRELQARVKALLRR 118
Cdd:cd17623   81 DIDRILGLELGADDYLPKPFNPRELVARIRAILRR 115
PRK10643 PRK10643
two-component system response regulator PmrA;
3-228 3.47e-41

two-component system response regulator PmrA;


Pssm-ID: 182612 [Multi-domain]  Cd Length: 222  Bit Score: 140.17  E-value: 3.47e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798   3 KILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRK-TSSVPILMLSAK 81
Cdd:PRK10643   2 KILIVEDDTLLLQGLILALQTEGYACDCASTAREAEALLESGHYSLVVLDLGLPDEDGLHLLRRWRQkKYTLPVLILTAR 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798  82 DSEFDKVIGLELGADDYVTKPFSNRELQARVKALLRRSQpmpvdGQeADSKpqpIQIGDLEIVPDAYVAKKYGEELDLTH 161
Cdd:PRK10643  82 DTLEDRVAGLDVGADDYLVKPFALEELHARIRALIRRHQ-----GQ-GENE---LQVGNLTLNLGRQQVWLDGQELILTP 152

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 892137798 162 REFELLYHLASHTGQVITREHLLETVWGYDYFGDVRTVDVTVRRLREKIEDtpsrpEYILTRRGVGY 228
Cdd:PRK10643 153 KEFALLSRLMLKAGSPVHREILYQDIYNWDDEPSSNTLEVHIHNLRDKVGK-----DRIRTVRGFGY 214
REC_OmpR_PrrA-like cd17627
phosphoacceptor receiver (REC) domain of PrrA-like OmpR family response regulators; The ...
 4-118 4.18e-41

phosphoacceptor receiver (REC) domain of PrrA-like OmpR family response regulators; The Mycobacterium tuberculosis PrrA is part of the PrrA/PrrB two-component system (TCS) that has been implicated in early intracellular multiplication and is essential for viability. Also included in this subfamily is Mycobacterium tuberculosis MprA, part of the MprAB TCS that regulates EspR, a key regulator of the ESX-1 secretion system, and is required for establishment and maintenance of persistent infection in a tissue- and stage-specific fashion. PrrA and MprA belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381142 [Multi-domain]  Cd Length: 116  Bit Score: 136.36  E-value: 4.18e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798   4 ILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRKT-SSVPILMLSAKD 82
Cdd:cd17627    1 ILVVDDDRAVRESLRRSLRFEGYEVETAVDGAEALRVISGNRPDAVVLDVMMPRLDGLEVCRRLRAAgNDLPILVLTARD 80

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 892137798  83 SEFDKVIGLELGADDYVTKPFSNRELQARVKALLRR 118
Cdd:cd17627   81 SVSDRVAGLDAGADDYLVKPFALEELLARVRALLRR 116
REC_OmpR_BfmR-like cd19939
phosphoacceptor receiver (REC) domain of BfmR-like OmpR family response regulators; ...
 3-118 2.39e-40

phosphoacceptor receiver (REC) domain of BfmR-like OmpR family response regulators; Acinetobacter baumannii BfmR is part of the BfmR/S two-component system that functions as the master regulator of biofilm initiation. BfmR confers resistance to complement-mediated bactericidal activity, independent of capsular polysaccharide, and also increases resistance to the clinically important antimicrobials meropenem and colistin, making it a potential antimicrobial target. Its inhibition would have the dual benefit of significantly decreasing in vivo survival and increasing sensitivity to selected antimicrobials. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381166 [Multi-domain]  Cd Length: 116  Bit Score: 134.42  E-value: 2.39e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798   3 KILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRKTSSVPILMLSAKD 82
Cdd:cd19939    1 RILIVEDELELARLTRDYLIKAGLEVSVFTDGQRAVRRIIDEQPSLVVLDIMLPGMDGLTVCREVREHSHVPILMLTART 80

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 892137798  83 SEFDKVIGLELGADDYVTKPFSNRELQARVKALLRR 118
Cdd:cd19939   81 EEMDRVLGLEMGADDYLCKPFSPRELLARVRALLRR 116
REC_OmpR_EcPhoP-like cd19934
phosphoacceptor receiver (REC) domain of EcPhoP-like OmpR family response regulators; ...
 4-119 1.02e-39

phosphoacceptor receiver (REC) domain of EcPhoP-like OmpR family response regulators; Escherichia coli PhoP (EcPhoP) is part of the PhoQ/PhoP two-component system (TCS) that regulates virulence genes and plays an essential role in the response of the bacteria to the environment of their mammalian hosts, sensing several stimuli such as extracellular magnesium limitation, low pH, the presence of cationic antimicrobial peptides, and osmotic upshift. This subfamily also includes Brucella suis FeuP, part of the FeuPQ TCS that is involved in the regulation of iron uptake, and Microchaete diplosiphon RcaC, which is required for chromatic adaptation. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381161 [Multi-domain]  Cd Length: 117  Bit Score: 132.79  E-value: 1.02e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798   4 ILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRKTS-SVPILMLSAKD 82
Cdd:cd19934    1 LLLVEDDALLAAQLKEQLSDAGYVVDVAEDGEEALFQGEEEPYDLVVLDLGLPGMDGLSVLRRWRSEGrATPVLILTARD 80

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 892137798  83 SEFDKVIGLELGADDYVTKPFSNRELQARVKALLRRS 119
Cdd:cd19934   81 SWQDKVEGLDAGADDYLTKPFHIEELLARLRALIRRA 117
REC_OmpR_MtPhoP-like cd17615
phosphoacceptor receiver (REC) domain of MtPhoP-like OmpR family response regulators; ...
 3-119 2.20e-39

phosphoacceptor receiver (REC) domain of MtPhoP-like OmpR family response regulators; Mycobacterium tuberculosis PhoP (MtPhoP) is part of the PhoP/PhoR two-component system that is involved in phosphate control by stimulating expression of genes involved in scavenging, transport and mobilization of phosphate, and repressing the utilization of nitrogen sources. Also included in this subfamily is Mycobacterium tuberculosis transcriptional regulatory protein TcrX, part of the two-component regulatory system TcrY/TcrX that may be involved in virulence. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381131 [Multi-domain]  Cd Length: 118  Bit Score: 132.09  E-value: 2.20e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798   3 KILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRK-TSSVPILMLSAK 81
Cdd:cd17615    1 RVLVVDDEPNITELLSMALRYEGWDVETAADGAEALAAAREFRPDAVVLDIMLPDMDGLEVLRRLRAdGPDVPVLFLTAK 80

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 892137798  82 DSEFDKVIGLELGADDYVTKPFSNRELQARVKALLRRS 119
Cdd:cd17615   81 DSVEDRIAGLTAGGDDYVTKPFSLEEVVARLRALLRRS 118
REC_OmpR_PmrA-like cd17624
phosphoacceptor receiver (REC) domain of PmrA-like OmpR family response regulators; This ...
 4-117 1.06e-38

phosphoacceptor receiver (REC) domain of PmrA-like OmpR family response regulators; This subfamily contains various OmpR family response regulators including PmrA, BasR, QseB, tctD, and RssB, which are components of two-component regulatory systems (TCSs). The PmrA/PmrB TCS controls transcription of genes that are involved in lipopolysaccharide modification in the outer membrane of bacteria, increasing bacterial resistance to host-derived antimicrobial peptides. The BasS/BasR TCS functions as an iron- and zinc-sensing transcription regulator. The QseB/QseC TCS activates the flagella regulon by activating transcription of FlhDC. The RssA/RssB TCS regulates swarming behavior in Serratia marcescens. OmpR family DNA-binding response regulators contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381139 [Multi-domain]  Cd Length: 115  Bit Score: 130.30  E-value: 1.06e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798   4 ILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRKT-SSVPILMLSAKD 82
Cdd:cd17624    1 ILLVEDDALLGDGLKTGLRKAGYAVDWVRTGAEAEAALASGPYDLVILDLGLPDGDGLDLLRRWRRQgQSLPVLILTARD 80

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 892137798  83 SEFDKVIGLELGADDYVTKPFSNRELQARVKALLR 117
Cdd:cd17624   81 GVDDRVAGLDAGADDYLVKPFALEELLARLRALLR 115
CheY COG0784
CheY-like REC (receiver) domain, includes chemotaxis protein CheY and sporulation regulator ...
 1-121 1.17e-38

CheY-like REC (receiver) domain, includes chemotaxis protein CheY and sporulation regulator Spo0F [Signal transduction mechanisms];


Pssm-ID: 440547 [Multi-domain]  Cd Length: 128  Bit Score: 130.36  E-value: 1.17e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798   1 MKKILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRK---TSSVPILM 77
Cdd:COG0784    5 GKRILVVDDNPDNRELLRRLLERLGYEVTTAEDGAEALELLRAGPPDLILLDINMPGMDGLELLRRIRAlprLPDIPIIA 84

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 892137798  78 LSAKDSEFDKVIGLELGADDYVTKPFSNRELQARVKALLRRSQP 121
Cdd:COG0784   85 LTAYADEEDRERALEAGADDYLTKPVDPEELLEALRRLLARASA 128
REC_D1_PleD-like cd17538
first (D1) phosphoacceptor receiver (REC) domain of response regulator PleD and similar ...
 3-103 4.39e-38

first (D1) phosphoacceptor receiver (REC) domain of response regulator PleD and similar domains; PleD contains a REC domain (D1) with the phosphorylatable aspartate, a REC-like adaptor domain (D2), and the enzymatic diguanylate cyclase (DGC) domain, also called the GGDEF domain according to a conserved sequence motif, as its output domain. The GGDEF-containing PleD response regulators are global regulators of cell metabolism in some important human pathogens. This model describes D1 of PleD and similar domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381093 [Multi-domain]  Cd Length: 104  Bit Score: 128.38  E-value: 4.39e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798   3 KILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIR---KTSSVPILMLS 79
Cdd:cd17538    1 KILVVDDEPANRELLEALLSAEGYEVLTADSGQEALALAEEELPDLILLDVMMPGMDGFEVCRRLKedpETRHIPVIMIT 80

                         90       100
                 ....*....|....*....|....
gi 892137798  80 AKDSEFDKVIGLELGADDYVTKPF 103
Cdd:cd17538   81 ALDDREDRIRGLEAGADDFLSKPI 104
RpfG COG3437
Response regulator c-di-GMP phosphodiesterase, RpfG family, contains REC and HD-GYP domains ...
 1-120 6.09e-38

Response regulator c-di-GMP phosphodiesterase, RpfG family, contains REC and HD-GYP domains [Signal transduction mechanisms];


Pssm-ID: 442663 [Multi-domain]  Cd Length: 224  Bit Score: 131.83  E-value: 6.09e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798   1 MKKILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRK---TSSVPILM 77
Cdd:COG3437    6 APTVLIVDDDPENLELLRQLLRTLGYDVVTAESGEEALELLLEAPPDLILLDVRMPGMDGFELLRLLRAdpsTRDIPVIF 85

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 892137798  78 LSAKDSEFDKVIGLELGADDYVTKPFSNRELQARVKALLRRSQ 120
Cdd:COG3437   86 LTALADPEDRERALEAGADDYLTKPFDPEELLARVRNALELRR 128
REC_OmpR_CusR-like cd19935
phosphoacceptor receiver (REC) domain of CusR-like OmpR family response regulators; ...
 4-102 1.71e-37

phosphoacceptor receiver (REC) domain of CusR-like OmpR family response regulators; Escherichia coli CusR is part of the CusS/CusR two-component system (TCS) that is involved in response to copper and silver. Other members of this subfamily include Escherichia coli PcoR, Pseudomonas syringae CopR, and Streptomyces coelicolor CutR, which are all transcriptional regulatory proteins and components of TCSs that regulate genes involved in copper resistance and/or metabolism. member of the subfamily is Escherichia coli HprR (hydrogen peroxide response regulator), previously called YdeW, which is part of the HprSR (or YedVW) TCS involved in stress response to hydrogen peroxide, as well as Cupriavidus metallidurans CzcR, which is part of the CzcS/CzcR TCS involved in the control of cobalt, zinc, and cadmium homeostasis. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381162 [Multi-domain]  Cd Length: 100  Bit Score: 126.40  E-value: 1.71e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798   4 ILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRKT-SSVPILMLSAKD 82
Cdd:cd19935    1 ILVVEDEKKLAEYLKKGLTEEGYAVDVAYDGEDGLHLALTNEYDLIILDVMLPGLDGLEVLRRLRAAgKQTPVLMLTARD 80

                         90       100
                 ....*....|....*....|
gi 892137798  83 SEFDKVIGLELGADDYVTKP 102
Cdd:cd19935   81 SVEDRVKGLDLGADDYLVKP 100
REC_OmpR_BaeR-like cd19938
phosphoacceptor receiver (REC) domain of BaeR-like OmpR family response regulators; BaeR is ...
 3-116 1.85e-37

phosphoacceptor receiver (REC) domain of BaeR-like OmpR family response regulators; BaeR is part of the BaeSR two-component system that is involved in regulating genes that confer multidrug and metal resistance. In Salmonella, BaeSR induces AcrD and MdtABC drug efflux systems, increasing multidrug and metal resistance. In Escherichia coli, BaeR stimulates multidrug resistance via mdtABC (multidrug transporter ABC, formerly known as yegMNO) genes, which encode a resistance-nodulation-cell division (RND) drug efflux system. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381165 [Multi-domain]  Cd Length: 114  Bit Score: 127.11  E-value: 1.85e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798   3 KILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRKTSSVPILMLSAKD 82
Cdd:cd19938    1 RILIVEDEPKLAQLLIDYLRAAGYAPTLLAHGDQVLPYVRHTPPDLILLDLMLPGTDGLTLCREIRRFSDVPIIMVTARV 80

                         90       100       110
                 ....*....|....*....|....*....|....
gi 892137798  83 SEFDKVIGLELGADDYVTKPFSNRELQARVKALL 116
Cdd:cd19938   81 EEIDRLLGLELGADDYICKPYSPREVVARVKAIL 114
REC_OmpR_MtrA-like cd17626
phosphoacceptor receiver (REC) domain of MtrA-like OmpR family response regulators; MtrA is ...
 3-116 1.95e-37

phosphoacceptor receiver (REC) domain of MtrA-like OmpR family response regulators; MtrA is part of MtrA/MtrB (or MtrAB), a highly conserved two-component system (TCS) implicated in the regulation of cell division in the actinobacteria. In unicellular Mycobacterium tuberculosis, MtrAB coordinates DNA replication with cell division and regulates the transcription of resuscitation-promoting factor B. In filamentous Streptomyces venezuelae, it links antibiotic production to sporulation. MtrA belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381141 [Multi-domain]  Cd Length: 115  Bit Score: 126.82  E-value: 1.95e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798   3 KILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRKTSSVPILMLSAKD 82
Cdd:cd17626    2 RILVVDDDAALAEMIGIVLRGEGFDPAFCGDGTQALAAFREVRPDLVLLDLMLPGIDGIEVCRQIRAESGVPIVMLTAKS 81

                         90       100       110
                 ....*....|....*....|....*....|....
gi 892137798  83 SEFDKVIGLELGADDYVTKPFSNRELQARVKALL 116
Cdd:cd17626   82 DTVDVVLGLESGADDYVAKPFKPKELVARIRARL 115
REC_OmpR_KdpE-like cd17620
phosphoacceptor receiver (REC) domain of KdpE-like OmpR family response regulators; KdpE is a ...
 4-102 2.40e-37

phosphoacceptor receiver (REC) domain of KdpE-like OmpR family response regulators; KdpE is a component of the KdpD/KdpE two-component system (TCS) and is activated when histidine kinase KdpD senses a drop in external K+ concentration or upshift in ionic osmolarity, resulting in the expression of a heterooligomeric transporter KdpFABC. In addition, the KdpD/KdpE TCS is also an adaptive regulator involved in the virulence and intracellular survival of pathogenic bacteria. KdpE is a member of the OmpR family of DNA-binding response regulators that contain REC and winged helix-turn-helix (wHTH) DNA-binding output effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381135 [Multi-domain]  Cd Length: 99  Bit Score: 126.13  E-value: 2.40e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798   4 ILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRKTSSVPILMLSAKDS 83
Cdd:cd17620    1 ILVIEDEPQIRRFLRTALEAHGYRVFEAETGQEGLLEAATRKPDLIILDLGLPDMDGLEVIRRLREWSAVPVIVLSARDE 80

                         90
                 ....*....|....*....
gi 892137798  84 EFDKVIGLELGADDYVTKP 102
Cdd:cd17620   81 ESDKIAALDAGADDYLTKP 99
REC_OmpR_RegX3-like cd17621
phosphoacceptor receiver (REC) domain of RegX3-like OmpR family response regulators; RegX3 is ...
 4-102 2.43e-37

phosphoacceptor receiver (REC) domain of RegX3-like OmpR family response regulators; RegX3 is a member of the SenX3-RegX3 two-component system that is involved in phosphate-sensing signal transduction. Phosphorylated RegX3 functions as a transcriptional activator of phoA. It induces transcription in phosphate limiting environment and also controls expression of several critical metabolic enzymes in aerobic condition. RegX3 belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381136 [Multi-domain]  Cd Length: 99  Bit Score: 126.16  E-value: 2.43e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798   4 ILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRKTSSVPILMLSAKDS 83
Cdd:cd17621    1 VLVVEDEESFSDPLAYLLRKEGFEVTVATDGPAALAEFDRAGADIVLLDLMLPGLSGTEVCRQLRARSNVPVIMVTAKDS 80

                         90
                 ....*....|....*....
gi 892137798  84 EFDKVIGLELGADDYVTKP 102
Cdd:cd17621   81 EIDKVVGLELGADDYVTKP 99
PRK10336 PRK10336
two-component system response regulator QseB;
3-228 2.60e-37

two-component system response regulator QseB;


Pssm-ID: 182387 [Multi-domain]  Cd Length: 219  Bit Score: 130.02  E-value: 2.60e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798   3 KILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIR-KTSSVPILMLSAK 81
Cdd:PRK10336   2 RILLIEDDMLIGDGIKTGLSKMGFSVDWFTQGRQGKEALYSAPYDAVILDLTLPGMDGRDILREWReKGQREPVLILTAR 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798  82 DSEFDKVIGLELGADDYVTKPFSNRELQARVKALLRRSQpmpvdGQEADSkpqpIQIGDLEIVPDAYVAKKYGEELDLTH 161
Cdd:PRK10336  82 DALAERVEGLRLGADDYLCKPFALIEVAARLEALMRRTN-----GQASNE----LRHGNVMLDPGKRIATLAGEPLTLKP 152

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 892137798 162 REFELLYHLASHTGQVITREHLLETVWGYDYFGDVRTVDVTVRRLREKIEDtpsrpEYILTRRGVGY 228
Cdd:PRK10336 153 KEFALLELLMRNAGRVLPRKLIEEKLYTWDEEVTSNAVEVHVHHLRRKLGS-----DFIRTVHGIGY 214
PRK15479 PRK15479
transcriptional regulator TctD;
3-228 1.87e-36

transcriptional regulator TctD;


Pssm-ID: 185376 [Multi-domain]  Cd Length: 221  Bit Score: 127.92  E-value: 1.87e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798   3 KILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRKT-SSVPILMLSAK 81
Cdd:PRK15479   2 RLLLAEDNRELAHWLEKALVQNGFAVDCVFDGLAADHLLQSEMYALAVLDINMPGMDGLEVLQRLRKRgQTLPVLLLTAR 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798  82 DSEFDKVIGLELGADDYVTKPFSNRELQARVKALLRRSQPMPVDGQeadskpqpiQIGDLEIVPDAYVAKKyGEELDLTH 161
Cdd:PRK15479  82 SAVADRVKGLNVGADDYLPKPFELEELDARLRALLRRSAGQVQEVQ---------QLGELIFHDEGYFLLQ-GQPLALTP 151

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 892137798 162 REFELLYHLASHTGQVITREHLLETVWGYDYFGDVRTVDVTVRRLREKIEDTPSRpeyILTRRGVGY 228
Cdd:PRK15479 152 REQALLTVLMYRRTRPVSRQQLFEQVFSLNDEVSPESIELYIHRLRKKLQGSDVR---ITTLRGLGY 215
REC_OmpR_kpRstA-like cd17622
phosphoacceptor receiver (REC) domain of kpRstA-like OmpR family response regulators; ...
 3-117 3.30e-35

phosphoacceptor receiver (REC) domain of kpRstA-like OmpR family response regulators; Klebsiella pneumoniae RstA (kpRstA) is part of the RstA/RstB two-component regulatory system that may play a regulatory role in virulence. It belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381137 [Multi-domain]  Cd Length: 116  Bit Score: 121.33  E-value: 3.30e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798   3 KILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRKTSSVPILMLSAKD 82
Cdd:cd17622    2 RILLVEDDPKLARLIADFLESHGFNVVVEHRGDRALEVIAREKPDAVLLDIMLPGIDGLTLCRDLRPKYQGPILLLTALD 81

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 892137798  83 SEFDKVIGLELGADDYVTKPFSNRELQARVKALLR 117
Cdd:cd17622   82 SDIDHILGLELGADDYVVKPVEPAVLLARLRALLR 116
Response_reg pfam00072
Response regulator receiver domain; This domain receives the signal from the sensor partner in ...
 4-113 6.73e-35

Response regulator receiver domain; This domain receives the signal from the sensor partner in bacterial two-component systems. It is usually found N-terminal to a DNA binding effector domain.


Pssm-ID: 395025 [Multi-domain]  Cd Length: 111  Bit Score: 120.33  E-value: 6.73e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798    4 ILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRKTS-SVPILMLSAKD 82
Cdd:pfam00072   1 VLIVDDDPLIRELLRQLLEKEGYVVAEADDGKEALELLKEERPDLILLDINMPGMDGLELLKRIRRRDpTTPVIILTAHG 80

                          90       100       110
                  ....*....|....*....|....*....|.
gi 892137798   83 SEFDKVIGLELGADDYVTKPFSNRELQARVK 113
Cdd:pfam00072  81 DEDDAVEALEAGADDFLSKPFDPDELLAAIR 111
Trans_reg_C pfam00486
Transcriptional regulatory protein, C terminal;
154-230 8.50e-35

Transcriptional regulatory protein, C terminal;


Pssm-ID: 425712 [Multi-domain]  Cd Length: 77  Bit Score: 118.77  E-value: 8.50e-35
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 892137798  154 GEELDLTHREFELLYHLASHTGQVITREHLLETVWGYDYFGDVRTVDVTVRRLREKIEDTPSRPEYILTRRGVGYYM 230
Cdd:pfam00486   1 GEEVELTPKEFKLLELLAENPGRVVSREQLLEEVWGEDYDVDDNTVDVHISRLRKKLEDDPRDPRLIKTVRGVGYRL 77
AtoC COG2204
DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, ...
 1-120 9.01e-35

DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, and a Fis-type DNA-binding domains [Signal transduction mechanisms];


Pssm-ID: 441806 [Multi-domain]  Cd Length: 418  Bit Score: 128.16  E-value: 9.01e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798   1 MKKILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRKT-SSVPILMLS 79
Cdd:COG2204    2 MARILVVDDDPDIRRLLKELLERAGYEVETAASGEEALALLREEPPDLVLLDLRMPGMDGLELLRELRALdPDLPVILLT 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 892137798  80 AKDSEFDKVIGLELGADDYVTKPFSNRELQARVKALLRRSQ 120
Cdd:COG2204   82 GYGDVETAVEAIKAGAFDYLTKPFDLEELLAAVERALERRR 122
REC_OmpR_NsrR-like cd18159
phosphoacceptor receiver (REC) domain of Streptococcus agalactiae NsrR-like OmpR family ...
 4-116 3.30e-34

phosphoacceptor receiver (REC) domain of Streptococcus agalactiae NsrR-like OmpR family response regulators; Streptococcus agalactiae NsrR is a lantibiotic resistance-associated response regulator and is part of the nisin resistance operon. It is a member of the NsrRK two-component system (TCS) that is involved in the regulation of lantibiotic resistance genes such as a membrane-associated lipoprotein of LanI, and the nsr gene cluster which encodes for the resistance protein NSR and the ABC transporter NsrFP, both conferring resistance against nisin. This subfamily also includes Staphylococcus epidermidis GraR, part of the GraR/GraS TCS involved in resistance against cationic antimicrobial peptides, and Bacillus subtilis BceR, part of the BceS/BceR TCS involved in the regulation of bacitracin resistance. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381143 [Multi-domain]  Cd Length: 113  Bit Score: 118.54  E-value: 3.30e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798   4 ILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRKTSSVPILMLSAKDS 83
Cdd:cd18159    1 ILIVEDDETIASLLKKHLEKWGYEVVLIEDFEDVLEEFLQFKPDLVLLDINLPYFDGFYWCREIRQISNVPIIFISSRDD 80

                         90       100       110
                 ....*....|....*....|....*....|...
gi 892137798  84 EFDKVIGLELGADDYVTKPFSNRELQARVKALL 116
Cdd:cd18159   81 NMDQVMAINMGGDDYITKPFDLDVLLAKIKAIL 113
trans_reg_C cd00383
DNA-binding effector domain of two-component system response regulators; Bacteria and some ...
 141-230 6.29e-34

DNA-binding effector domain of two-component system response regulators; Bacteria and some eukaryotes use two-component signal transduction systems to detect and respond to changes in the environment. The systems consists of a sensor histidine kinase and a response regulator. The former autophosphorylates a histidine residue on detecting an external stimulus. The phosphate is then transferred to an invariant aspartate residue in a highly conserved receiver domain of the response regulator. Phosphorylation activates a variable effector domain of the response regulator, which triggers the cellular response. This C-terminal effector domain belongs to the winged helix-turn-helix family of transcriptional regulators and contains DNA and RNA polymerase binding sites. Several dimers or monomers bind head to tail to small tandem repeats upstream of the genes. The RNA polymerase binding sites interact with the alpha or sigma subunit of RNA polymerase.


Pssm-ID: 294013 [Multi-domain]  Cd Length: 89  Bit Score: 117.19  E-value: 6.29e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798 141 LEIVPDAYVAKKYGEELDLTHREFELLYHLASHTGQVITREHLLETVWGYDYFGDVRTVDVTVRRLREKIEDTPSrPEYI 220
Cdd:cd00383    1 LRLDPARREVTVDGEEVELTPKEFELLELLARNPGRVVSREELLEAVWGYDYEVDDRTVDVHISRLRKKLEDDPE-PRLI 79

                         90
                 ....*....|
gi 892137798 221 LTRRGVGYYM 230
Cdd:cd00383   80 KTVRGVGYRL 89
REC cd00156
phosphoacceptor receiver (REC) domain of response regulators (RRs) and pseudo response ...
 5-102 6.11e-33

phosphoacceptor receiver (REC) domain of response regulators (RRs) and pseudo response regulators (PRRs); Two-component systems (TCSs) involving a sensor and a response regulator are used by bacteria to adapt to changing environments. Processes regulated by two-component systems in bacteria include sporulation, pathogenicity, virulence, chemotaxis, and membrane transport. Response regulators (RRs) share the common phosphoacceptor REC domain and different effector/output domains such as DNA, RNA, ligand-binding, protein-binding, or enzymatic domains. Response regulators regulate transcription, post-transcription or post-translation, or have functions such as methylesterases, adenylate or diguanylate cyclase, c-di-GMP-specific phosphodiesterases, histidine kinases, serine/threonine protein kinases, and protein phosphatases, depending on their output domains. The function of some output domains are still unknown. TCSs are found in all three domains of life - bacteria, archaea, and eukaryotes, however, the presence and abundance of particular RRs vary between the lineages. Archaea encode very few RRs with DNA-binding output domains; most are stand-alone REC domains. Among eukaryotes, TCSs are found primarily in protozoa, fungi, algae, and green plants. REC domains function as phosphorylation-mediated switches within RRs, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381085 [Multi-domain]  Cd Length: 99  Bit Score: 115.02  E-value: 6.11e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798   5 LIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRKTSS-VPILMLSAKDS 83
Cdd:cd00156    1 LIVDDDPAIRELLKSLLEREGYEVDTAADGEEALELLREERPDLVLLDLMMPGMDGLELLRKLRELPPdIPVIVLTAKAD 80

                         90
                 ....*....|....*....
gi 892137798  84 EFDKVIGLELGADDYVTKP 102
Cdd:cd00156   81 EEDAVRALELGADDYLVKP 99
PRK13856 PRK13856
two-component response regulator VirG; Provisional
 1-230 9.62e-33

two-component response regulator VirG; Provisional


Pssm-ID: 172377 [Multi-domain]  Cd Length: 241  Bit Score: 118.76  E-value: 9.62e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798   1 MKKILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRKTSSVPILMLS- 79
Cdd:PRK13856   1 MKHVLVIDDDVAMRHLIVEYLTIHAFKVTAVADSQQFNRVLASETVDVVVVDLNLGREDGLEIVRSLATKSDVPIIIISg 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798  80 AKDSEFDKVIGLELGADDYVTKPFSNRELQARVKALLRRSQPMPvdgQEADSKpqPIQIGDLEI-VPDAYVAKKYGEELD 158
Cdd:PRK13856  81 DRLEEADKVVALELGATDFIAKPFGTREFLARIRVALRVRPNVV---RTKDRR--SFCFADWTLnLRQRRLISEAGGEVK 155

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 892137798 159 LTHREFELLYHLASHTGQVITREHLL-------ETVwgYDyfgdvRTVDVTVRRLREKIEDTPSRPEYILTRRGVGYYM 230
Cdd:PRK13856 156 LTAGEFNLLVAFLEKPRDVLSREQLLiasrvreEEV--YD-----RSIDVLILRLRRKLEQDPANPQLIKTARGAGYFF 227
REC_OmpR_ArcA_TorR-like cd17619
phosphoacceptor receiver (REC) domain of ArcA- and TorR-like OmpR family response regulators; ...
 4-113 8.04e-31

phosphoacceptor receiver (REC) domain of ArcA- and TorR-like OmpR family response regulators; This subfamily includes Escherichia coli TorR and ArcA, both OmpR family response regulators that mediate adaptation to changes in various respiratory growth conditions. The TorS-TorR two-component system (TCS) is responsible for the tight regulation of the torCAD operon, which encodes the trimethylamine N-oxide (TMAO) reductase respiratory system in response to anaerobic conditions and the presence of TMAO. The ArcA-ArcB TCS is involved in cell growth during anaerobiosis. ArcA is a global regulator that controls more than 30 operons involved in redox regulation (the Arc modulon). OmpR family DNA-binding response regulators are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381134 [Multi-domain]  Cd Length: 113  Bit Score: 109.78  E-value: 8.04e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798   4 ILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRKTSSVPILMLSAKDS 83
Cdd:cd17619    3 ILIVEDEPVTRATLKSYFEQEGYDVSEAGDGEEMRQILARQDIDLVLLDINLPGKDGLSLTRELREQSEVGIILVTGRDD 82

                         90       100       110
                 ....*....|....*....|....*....|
gi 892137798  84 EFDKVIGLELGADDYVTKPFSNRELQARVK 113
Cdd:cd17619   83 EVDRIVGLEIGADDYVTKPFNPRELLVRAK 112
Trans_reg_C smart00862
Transcriptional regulatory protein, C terminal; This domain is almost always found associated ...
 154-230 1.37e-30

Transcriptional regulatory protein, C terminal; This domain is almost always found associated with the response regulator receiver domain. It may play a role in DNA binding.


Pssm-ID: 214866 [Multi-domain]  Cd Length: 76  Bit Score: 108.02  E-value: 1.37e-30
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 892137798   154 GEELDLTHREFELLYHLASHTGQVITREHLLETVWGYDYFGDVRTVDVTVRRLREKIEDtPSRPEYILTRRGVGYYM 230
Cdd:smart00862   1 GEPIKLTPKEFRLLELLLRNPGRVVSREELLEAVWGDDEDVDDNTLDVHISRLRKKLED-DGDPRLIETVRGVGYRL 76
pleD PRK09581
response regulator PleD; Reviewed
 3-117 2.25e-30

response regulator PleD; Reviewed


Pssm-ID: 236577 [Multi-domain]  Cd Length: 457  Bit Score: 116.54  E-value: 2.25e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798   3 KILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIR---KTSSVPILMLS 79
Cdd:PRK09581   4 RILVVDDIPANVKLLEAKLLAEYYTVLTASSGAEAIAICEREQPDIILLDVMMPGMDGFEVCRRLKsdpATTHIPVVMVT 83

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 892137798  80 AKDSEFDKVIGLELGADDYVTKPFSNRELQARVKALLR 117
Cdd:PRK09581  84 ALDDPEDRVRGLEAGADDFLTKPINDVALFARVKSLTR 121
REC_PA4781-like cd19920
phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase PA4781 and similar ...
 4-103 5.12e-30

phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase PA4781 and similar domains; Pseudomonas aeruginosa cyclic di-GMP phosphodiesterase PA4781 contains an N-terminal REC domain and a C-terminal catalytic HD-GYP domain, characteristics of RpfG family response regulators. PA4781 is involved in cyclic di-3',5'-GMP (c-di-GMP) hydrolysis/degradation in a two-step reaction via the linear intermediate pGpG to produce GMP. Its unphosphorylated REC domain prevents accessibility of c-di-GMP to the active site. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381147 [Multi-domain]  Cd Length: 103  Bit Score: 107.60  E-value: 5.12e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798   4 ILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIR---KTSSVPILMLSA 80
Cdd:cd19920    1 ILIVDDVPDNLRLLSELLRAAGYRVLVATDGQQALQRAQAEPPDLILLDVMMPGMDGFEVCRRLKadpATRHIPVIFLTA 80

                         90       100
                 ....*....|....*....|...
gi 892137798  81 KDSEFDKVIGLELGADDYVTKPF 103
Cdd:cd19920   81 LTDTEDKVKGFELGAVDYITKPF 103
REC_RR468-like cd17552
phosphoacceptor receiver (REC) domain of Thermotoga maritima response regulator RR468 and ...
 1-116 8.02e-30

phosphoacceptor receiver (REC) domain of Thermotoga maritima response regulator RR468 and similar domains; Thermotoga maritima RR468 (encoded by gene TM0468) is the cognate response regulator (RR) of the class I histidine kinase HK853 (product of gene TM0853). HK853/RR468 comprise a two-component system (TCS) that couples environmental stimuli to adaptive responses. This subfamily also includes Fremyella diplosiphon complementary adaptation response regulator homolog RcaF, a small RR that is involved in four-step phosphorelays of the complementary chromatic adaptation (CCA) system that occurs in many cyanobacteria. Both RR468 and RcaF are stand-alone RRs containing only a REC domain with no output/effector domain. The REC domain itself functions as an effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381104 [Multi-domain]  Cd Length: 121  Bit Score: 107.64  E-value: 8.02e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798   1 MKKILIVDDEKPISDIIKFNMTKE-GYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIR---KTSSVPIL 76
Cdd:cd17552    1 SKRILVIDDEEDIREVVQACLEKLaGWEVLTASSGQEGLEKAATEQPDAILLDVMMPDMDGLATLKKLQanpETQSIPVI 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 892137798  77 MLSAKDSEFDKVIGLELGADDYVTKPFSNRELQARVKALL 116
Cdd:cd17552   81 LLTAKAQPSDRQRFASLGVAGVIAKPFDPLTLAEQIAKLL 120
YesN COG4753
Two-component response regulator, YesN/AraC family, consists of REC and AraC-type DNA-binding ...
 3-102 2.74e-29

Two-component response regulator, YesN/AraC family, consists of REC and AraC-type DNA-binding domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443786 [Multi-domain]  Cd Length: 103  Bit Score: 105.63  E-value: 2.74e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798   3 KILIVDDEKPISDIIKFNMTKE-GYEVV-TAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRKTS-SVPILMLS 79
Cdd:COG4753    1 KVLIVDDEPLIREGLKRILEWEaGFEVVgEAENGEEALELLEEHKPDLVITDINMPGMDGLELLEAIRELDpDTKIIILS 80

                         90       100
                 ....*....|....*....|....
gi 892137798  80 AkDSEFDKVI-GLELGADDYVTKP 102
Cdd:COG4753   81 G-YSDFEYAQeAIKLGADDYLLKP 103
CitB COG4565
DNA-binding response regulator DpiB of citrate/malate metabolism [Transcription, Signal ...
 1-130 6.79e-29

DNA-binding response regulator DpiB of citrate/malate metabolism [Transcription, Signal transduction mechanisms];


Pssm-ID: 443622 [Multi-domain]  Cd Length: 138  Bit Score: 105.82  E-value: 6.79e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798   1 MKKILIVDDEKPISDIIKFNMTK-EGYEVV-TAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRK-TSSVPILM 77
Cdd:COG4565    3 MIRVLIVEDDPMVAELLRRYLERlPGFEVVgVASSGEEALALLAEHRPDLILLDIYLPDGDGLELLRELRArGPDVDVIV 82

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 892137798  78 LSAKDSEFDKVIGLELGADDYVTKPFSNRELQARVKALLRRSQPMPVDgQEAD 130
Cdd:COG4565   83 ITAARDPETVREALRAGVVDYLIKPFTFERLREALERYLEYRRLLRED-QEED 134
Spo0F COG5803
Stage 0 sporulation initiation response regulator Spo0F [Cell cycle control, cell division, ...
 1-116 7.32e-29

Stage 0 sporulation initiation response regulator Spo0F [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444505 [Multi-domain]  Cd Length: 119  Bit Score: 104.88  E-value: 7.32e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798   1 MKKILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRKT-SSVPILMLS 79
Cdd:COG5803    2 MKKILIVDDQAGIRMLLKEVLKKEGYEVFQAANGKEALEKVKELKPDLVLLDMKMPGMDGIEILKEIKEIdPDIPVIMMT 81

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 892137798  80 AkDSEFDKVI-GLELGADDYVTKPFSNRELQARVKALL 116
Cdd:COG5803   82 A-YGELDMVEeAKELGAKGYFTKPFDIDELREAVNKLL 118
REC_RpfG-like cd17551
phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase response regulator ...
 3-113 4.31e-28

phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase response regulator RpfG and similar proteins; Cyclic di-GMP phosphodiesterase response regulator RpfG, together with sensory/regulatory protein RpfC, constitute a two-component system implicated in sensing and responding to the diffusible signal factor (DSF) that is essential for cell-cell signaling. RpfC is a hybrid sensor/histidine kinase that phosphorylates and activates RpfG, which degrades cyclic di-GMP to GMP, leading to the activation of Clp, a global transcriptional regulator that regulates a large set of genes in the DSF pathway. RpfG contains a CheY-like receiver domain attached to a histidine-aspartic acid-glycine-tyrosine-proline (HD-GYP) cyclic di-GMP phosphodiesterase domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381103 [Multi-domain]  Cd Length: 118  Bit Score: 102.91  E-value: 4.31e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798   3 KILIVDDEKPISDIIKFNMTKEGYEVVTAF-NGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRKTSS---VPILML 78
Cdd:cd17551    2 RILIVDDNPTNLLLLEALLRSAGYLEVVSFtDPREALAWCRENPPDLILLDYMMPGMDGLEFIRRLRALPGledVPIVMI 81

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 892137798  79 SAKDSEFDKVIGLELGADDYVTKPFSNRELQARVK 113
Cdd:cd17551   82 TADTDREVRLRALEAGATDFLTKPFDPVELLARVR 116
PRK10816 PRK10816
two-component system response regulator PhoP;
3-228 4.43e-28

two-component system response regulator PhoP;


Pssm-ID: 182755 [Multi-domain]  Cd Length: 223  Bit Score: 105.98  E-value: 4.43e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798   3 KILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIR-KTSSVPILMLSAK 81
Cdd:PRK10816   2 RVLVVEDNALLRHHLKVQLQDAGHQVDAAEDAKEADYYLNEHLPDIAIVDLGLPDEDGLSLIRRWRsNDVSLPILVLTAR 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798  82 DSEFDKVIGLELGADDYVTKPFSNRELQARVKALLRRSQPMpvdgqeadsKPQPIQIGDLEIVPDAYVAKKYGEELDLTH 161
Cdd:PRK10816  82 ESWQDKVEVLSAGADDYVTKPFHIEEVMARMQALMRRNSGL---------ASQVISLPPFQVDLSRRELSINDEVIKLTA 152

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 892137798 162 REFELLYHLASHTGQVITREHLLETVWGYDYFGDVRTVDVTVRRLREKIEDTPSrPEYILTRRGVGY 228
Cdd:PRK10816 153 FEYTIMETLIRNNGKVVSKDSLMLQLYPDAELRESHTIDVLMGRLRKKIQAQYP-QEVITTVRGQGY 218
REC_TrrA-like cd17554
phosphoacceptor receiver (REC) domain of Thermotoga maritima response regulator TrrA and ...
 2-115 4.61e-28

phosphoacceptor receiver (REC) domain of Thermotoga maritima response regulator TrrA and similar domains; Thermotoga maritima contains a two-component signal transduction system (TCS) composed of the ThkA sensory histidine kinase (HK) and its cognate response regulator (RR) TrrA; the specific function of the system is unknown. TCSs couple environmental stimuli to adaptive responses. TrrA is a stand-alone RR containing only a REC domain with no output/effector domain. The REC domain itself functions as an effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381106 [Multi-domain]  Cd Length: 113  Bit Score: 102.68  E-value: 4.61e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798   2 KKILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIR-KTSSVPILMLSA 80
Cdd:cd17554    1 KKILVVDDEENIRELYKEELEDEGYEVVTAGNGEEALEKLESEDPDLVILDIKMPGMDGLETLRKIReKKPDLPVIICTA 80

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 892137798  81 ---KDSEFDKvigleLGADDYVTKPFSNRELQARVKAL 115
Cdd:cd17554   81 yseYKSDFSS-----WAADAYVVKSSDLTELKETIKRL 113
REC_OmpR_ChvI-like cd19936
phosphoacceptor receiver (REC) domain of ChvI-like OmpR family response regulators; ...
 4-102 3.71e-27

phosphoacceptor receiver (REC) domain of ChvI-like OmpR family response regulators; Sinorhizobium meliloti ChvI is part of the ExoS/ChvI two-component regulatory system (TCS) that is required for nitrogen-fixing symbiosis and exopolysaccharide synthesis. ExoS/ChvI also play important roles in regulating biofilm formation, motility, nutrient utilization, and the viability of free-living bacteria. ChvI belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381163 [Multi-domain]  Cd Length: 99  Bit Score: 100.21  E-value: 3.71e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798   4 ILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRKTSSVPILMLSAKDS 83
Cdd:cd19936    1 IALVDDDRNILTSVSMALEAEGFSVETYTDGASALDGLNARPPDLAILDIKMPRMDGMELLQRLRQKSTLPVIFLTSKDD 80

                         90
                 ....*....|....*....
gi 892137798  84 EFDKVIGLELGADDYVTKP 102
Cdd:cd19936   81 EIDEVFGLRMGADDYITKP 99
REC_RssB-like cd17555
phosphoacceptor receiver (REC) domain of Pseudomonas aeruginosa RssB and similar domains; ...
 2-102 3.82e-27

phosphoacceptor receiver (REC) domain of Pseudomonas aeruginosa RssB and similar domains; Pseudomonas aeruginosa RssB is an orphan atypical response regulator containing a REC domain and a PP2C-type protein phosphatase output domain. Its function is still unknown. Escherichia RssB, which is not included in this subfamily, is a ClpX adaptor protein which alters ClpX specificity by mediating a specific interaction between ClpX and the substrates such as RpoS, an RNA polymerase sigma factor. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381107 [Multi-domain]  Cd Length: 116  Bit Score: 100.35  E-value: 3.82e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798   2 KKILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRKTSS-VPILMLSA 80
Cdd:cd17555    1 ATILVIDDDEVVRESIAAYLEDSGFQVLQAADGRQGLELFRSEQPDLVLCDLRMPEMDGLEVLKQITKESPdTPVIVVSG 80

                         90       100
                 ....*....|....*....|..
gi 892137798  81 KDSEFDKVIGLELGADDYVTKP 102
Cdd:cd17555   81 AGVMSDAVEALRLGAWDYLTKP 102
REC_hyHK_CKI1_RcsC-like cd17546
phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinases/response regulators ...
 4-108 2.95e-26

phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinases/response regulators similar to Arabidopsis thaliana CKI1 and Escherichia coli RcsC; This family is composed of hybrid sensor histidine kinases/response regulators that are sensor histidine kinases (HKs) fused with a REC domain, similar to the sensor histidine kinase CKI1 from Arabidopsis thaliana, which is involved in multi-step phosphorelay (MSP) signaling that mediates responses to a variety of important stimuli in plants. MSP involves a signal being transferred from HKs via histidine phosphotransfer proteins (AHP1-AHP5) to nuclear response regulators. The CKI1 REC domain specifically interacts with the downstream signaling protein AHP2, AHP3 and AHP5. The plant MSP system has evolved from the prokaryotic two-component system (TCS), which allows organisms to sense and respond to changes in environmental conditions. This family also includes bacterial hybrid sensor HKs such as Escherichia coli RcsC, which is a component of the Rcs signalling pathway that controls a variety of physiological functions like capsule synthesis, cell division, and motility. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381099 [Multi-domain]  Cd Length: 113  Bit Score: 97.93  E-value: 2.95e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798   4 ILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRK----TSSVPILMLS 79
Cdd:cd17546    1 VLVVDDNPVNRKVLKKLLEKLGYEVDVAENGQEALELLKEEPFDLVLMDLQMPVMDGLEATRRIREleggGRRTPIIALT 80

                         90       100
                 ....*....|....*....|....*....
gi 892137798  80 AKDSEFDKVIGLELGADDYVTKPFSNREL 108
Cdd:cd17546   81 ANALEEDREKCLEAGMDDYLSKPVKLDQL 109
REC_OmpR_VirG cd17594
phosphoacceptor receiver (REC) domain of VirG-like OmpR family response regulators; VirG is ...
 3-114 1.24e-25

phosphoacceptor receiver (REC) domain of VirG-like OmpR family response regulators; VirG is part of the VirA/VirG two-component system that regulates the expression of virulence (vir) genes. The histidine kinase VirA senses a phenolic wound response signal, undergoes autophosphorylation, and phosphorelays to the VirG response regulator, which induces transcription of the vir regulon. VirG belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381125 [Multi-domain]  Cd Length: 113  Bit Score: 96.36  E-value: 1.24e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798   3 KILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRKTSSVPILMLSA-K 81
Cdd:cd17594    1 HVLVVDDDAAMRHLLILYLRERGFDVTAAADGAEEARLMLHRRVDLVLLDLRLGQESGLDLLRTIRARSDVPIIIISGdR 80

                         90       100       110
                 ....*....|....*....|....*....|...
gi 892137798  82 DSEFDKVIGLELGADDYVTKPFSNRELQARVKA 114
Cdd:cd17594   81 RDEIDRVVGLELGADDYLAKPFGLRELLARVRA 113
REC_CheY cd17542
phosphoacceptor receiver (REC) domain of chemotaxis protein CheY; The chemotaxis response ...
 2-116 1.29e-25

phosphoacceptor receiver (REC) domain of chemotaxis protein CheY; The chemotaxis response regulator CheY contains a stand-alone REC domain. Chemotaxis is a behavior known for motile bacteria that directs their movement in response to chemical gradients. CheY is involved in transmitting sensory signals from chemoreceptors to the flagellar motors. Phosphorylated CheY interacts with the flagella switch components FliM and FliY, which causes counterclockwise rotation of the flagella, resulting in smooth swimming. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381097 [Multi-domain]  Cd Length: 117  Bit Score: 96.58  E-value: 1.29e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798   2 KKILIVDDEKPISDIIKFNMTKEGYEVV-TAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRK-TSSVPILMLS 79
Cdd:cd17542    1 KKVLIVDDAAFMRMMLKDILTKAGYEVVgEAANGEEAVEKYKELKPDLVTMDITMPEMDGIEALKEIKKiDPNAKVIMCS 80

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 892137798  80 AKDSEfDKVI-GLELGADDYVTKPFSNRELQARVKALL 116
Cdd:cd17542   81 AMGQE-EMVKeAIKAGAKDFIVKPFQPERVLEAVEKVL 117
REC_OmpR_CtrA cd17616
phosphoacceptor receiver (REC) domain of CtrA-like OmpR family response regulators; CtrA is ...
 4-116 1.79e-25

phosphoacceptor receiver (REC) domain of CtrA-like OmpR family response regulators; CtrA is part of the CckA-ChpT-CtrA phosphorelay that is conserved in alphaproteobacteria and is important in orchestrating the cell cycle, polar development, and flagellar biogenesis. CtrA is the master regulator of flagella synthesis genes and also regulates genes involved in the cell cycle, exopolysaccharide synthesis, and cyclic-di-GMP signaling. CtrA is active as a transcription factor when phosphorylated. It is a member of the OmpR family of DNA-binding response regulators, characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381132 [Multi-domain]  Cd Length: 114  Bit Score: 96.32  E-value: 1.79e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798   4 ILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRKTS-SVPILMLSAKD 82
Cdd:cd17616    1 VLLIEDDSATAQSIELMLKSEGFNVYTTDLGEEGLDLGKLYDYDIILLDLNLPDMSGYEVLRTLRLAKvKTPILILSGLA 80

                         90       100       110
                 ....*....|....*....|....*....|....
gi 892137798  83 SEFDKVIGLELGADDYVTKPFSNRELQARVKALL 116
Cdd:cd17616   81 DIEDKVKGLGFGADDYMTKPFHKDELVARIHAIV 114
REC_YesN-like cd17536
phosphoacceptor receiver (REC) domain of YesN and related helix-turn-helix containing response ...
 4-118 2.06e-25

phosphoacceptor receiver (REC) domain of YesN and related helix-turn-helix containing response regulators; This family is composed of uncharacterized response regulators that contain a REC domain and a AraC family helix-turn-helix (HTH) DNA-binding output domain, including Bacillus subtilis uncharacterized transcriptional regulatory protein YesN and Staphylococcus aureus uncharacterized response regulatory protein SAR0214. YesN is a member of the two-component regulatory system YesM/YesN and SAR0214 is a member of the probable two-component regulatory system SAR0215/SAR0214. Also included in this family is the AlgR-like group of LytTR/AlgR family response, which includes Pseudomonas aeruginosa positive alginate biosynthesis regulatory protein AlgR and Bacillus subtilis sensory transduction protein LytT, among others. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381091 [Multi-domain]  Cd Length: 121  Bit Score: 96.25  E-value: 2.06e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798   4 ILIVDDEKPISDIIK--FNMTKEGYEVV-TAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRKTS-SVPILMLS 79
Cdd:cd17536    1 VLIVDDEPLIREGLKklIDWEELGFEVVgEAENGEEALELIEEHKPDIVITDIRMPGMDGLELIEKIRELYpDIKIIILS 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 892137798  80 AKDsEFD---KviGLELGADDYVTKPFSNRELQARVKALLRR 118
Cdd:cd17536   81 GYD-DFEyaqK--AIRLGVVDYLLKPVDEEELEEALEKAKEE 119
REC_NtrX-like cd17550
phosphoacceptor receiver (REC) domain of nitrogen assimilation regulatory protein NtrX and ...
 4-104 2.63e-25

phosphoacceptor receiver (REC) domain of nitrogen assimilation regulatory protein NtrX and similar proteins; NtrX is part of the two-component regulatory system NtrY/NtrX that is involved in the activation of nitrogen assimilatory genes such as Gln. It is phosphorylated by the histidine kinase NtrY and interacts with sigma-54. NtrX is a member of the NtrC family, characterized by a domain architecture containing an N-terminal REC domain, followed by a central sigma-54 interaction/ATPase domain, and a C-terminal DNA binding domain. NtrC family response regulators are sigma54-dependent transcriptional activators. Also included in this subfamily is Aquifex aeolicus NtrC4. The ability of the central domain to hydrolyze ATP and thus to interact effectively with a complex of RNA polymerase, sigma54, and promoter, is controlled by the phosphorylation status of the REC domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381102 [Multi-domain]  Cd Length: 115  Bit Score: 95.64  E-value: 2.63e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798   4 ILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRKTSS-VPILMLSAKD 82
Cdd:cd17550    1 ILIVDDEEDIRESLSGILEDEGYEVDTAADGEEALKLIKERRPDLVLLDIWLPDMDGLELLKEIKEKYPdLPVIMISGHG 80

                         90       100
                 ....*....|....*....|..
gi 892137798  83 SEFDKVIGLELGADDYVTKPFS 104
Cdd:cd17550   81 TIETAVKATKLGAYDFIEKPLS 102
REC_CheY4-like cd17562
phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY4 and similar CheY ...
 2-116 4.19e-25

phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY4 and similar CheY family proteins; CheY family chemotaxis response regulators (RRs) comprise about 17% of bacterial RRs and almost half of all RRs in archaea. This subfamily contains Vibrio cholerae CheY4 and similar CheY family RRs. CheY proteins control bacterial motility and participate in signaling phosphorelays and in protein-protein interactions. CheY RRs contain only the REC domain with no output/effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381110 [Multi-domain]  Cd Length: 118  Bit Score: 95.45  E-value: 4.19e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798   2 KKILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRKTSS---VPILML 78
Cdd:cd17562    1 KKILAVDDSASIRQMVSFTLRGAGYEVVEAADGRDALSKAQSKKFDLIITDQNMPNMDGIELIKELRKLPAykfTPILML 80

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 892137798  79 SAKDSEFDKVIGLELGADDYVTKPFSNRELQARVKALL 116
Cdd:cd17562   81 TTESSDEKKQEGKAAGATGWLVKPFDPEQLLEVVKKVL 118
REC_DC-like cd17534
phosphoacceptor receiver (REC) domain of modulated diguanylate cyclase and similar domains; ...
 2-110 1.49e-24

phosphoacceptor receiver (REC) domain of modulated diguanylate cyclase and similar domains; This groups includes a modulated diguanylate cyclase containing a PAS sensor domain from Desulfovibrio desulfuricans G20. Members of this group contain N-terminal REC domains and various output domains including the GGDEF, histidine kinase, and helix-turn-helix (HTH) DNA binding domains. Also included in this family is Mycobacterium tuberculosis PdtaR, a transcriptional antiterminator that contains a REC domain and an ANTAR RNA-binding output domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381089 [Multi-domain]  Cd Length: 117  Bit Score: 93.63  E-value: 1.49e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798   2 KKILIVDDEKPISDIIKFNMTKEGYEVV-TAFNGREALEQFEAEQPDIIILDLMLP-EIDGLEVAKTIRKTSSVPILMLS 79
Cdd:cd17534    1 KKILIVEDEAIIALDLKEILESLGYEVVgIADSGEEAIELAEENKPDLILMDINLKgDMDGIEAAREIREKFDIPVIFLT 80

                         90       100       110
                 ....*....|....*....|....*....|...
gi 892137798  80 AKDSE--FDKVIglELGADDYVTKPFSNRELQA 110
Cdd:cd17534   81 AYSDEetLERAK--ETNPYGYLVKPFNERELKA 111
REC_hyHK cd17598
phosphoacceptor receiver (REC) domain of uncharacterized hybrid sensor histidine kinase ...
 4-116 2.70e-24

phosphoacceptor receiver (REC) domain of uncharacterized hybrid sensor histidine kinase/response regulators; Typically, two-component regulatory systems (TCSs) consist of a sensor (histidine kinase) that responds to specific input(s) by modifying the output of a cognate response regulator (RR). TCSs allow organisms to sense and respond to changes in environmental conditions. Hybrid sensor histidine kinase/response regulators contain all the elements of a classical TCS in a single polypeptide chain. RRs share the common phosphoacceptor REC domain and different effector/output domains such as DNA, RNA, ligand-binding, protein-binding, or enzymatic domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381128 [Multi-domain]  Cd Length: 118  Bit Score: 93.16  E-value: 2.70e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798   4 ILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIR---KTSSVPILMLSA 80
Cdd:cd17598    1 ILIVEDSPTQAEQLKHILEEQGYKVQVARNGREALAMLAEHRPTLVISDIVMPEMDGYELCRKIKsdpDLKDIPVILLTT 80

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 892137798  81 KDSEFDKVIGLELGADDYVTKPFSNRELQARVKALL 116
Cdd:cd17598   81 LSDPRDVIRGLECGADNFITKPYDEKYLLSRIKYIL 116
REC_2_DhkD-like cd17580
second phosphoacceptor receiver (REC) domain of Dictyostelium discoideum hybrid signal ...
 4-110 9.48e-24

second phosphoacceptor receiver (REC) domain of Dictyostelium discoideum hybrid signal transduction histidine kinase D and similar domains; Dictyostelium discoideum hybrid signal transduction histidine kinase D (DhkD) is a large protein that contains two histidine kinase (HK) and two REC domains on the intracellular side of a single pass transmembrane domain, and extracellular PAS and PAC domains that likely are involved in ligand binding. This model represents the second REC domain and similar domains. DhkD activates the cAMP phosphodiesterase RegA to ensure proper prestalk and prespore patterning, tip formation, and the vertical elongation of the mound into a finger, in Dictyostelium discoideum. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381118 [Multi-domain]  Cd Length: 112  Bit Score: 91.37  E-value: 9.48e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798   4 ILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRKT---SSVPILMLSA 80
Cdd:cd17580    1 ILVVDDNEDAAEMLALLLELEGAEVTTAHSGEEALEAAQRFRPDVILSDIGMPGMDGYELARRLRELpwlANTPAIALTG 80

                         90       100       110
                 ....*....|....*....|....*....|
gi 892137798  81 KDSEFDKVIGLELGADDYVTKPFSNRELQA 110
Cdd:cd17580   81 YGQPEDRERALEAGFDAHLVKPVDPDELIE 110
REC_CheB-like cd17541
phosphoacceptor receiver (REC) domain of chemotaxis response regulator protein-glutamate ...
 3-113 1.61e-23

phosphoacceptor receiver (REC) domain of chemotaxis response regulator protein-glutamate methylesterase CheB and similar chemotaxis proteins; Methylesterase CheB is a chemotaxis response regulator with an N-terminal REC domain and a C-terminal methylesterase domain. Chemotaxis is a behavior known in motile bacteria that directs their movement in response to chemical gradients. CheB is a phosphorylation-activated response regulator involved in the reversible modification of bacterial chemotaxis receptors. It catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR. The CheB REC domain packs against the active site of the C-terminal domain and inhibits methylesterase activity by directly restricting access to the active site. Also included in this family is chemotaxis response regulator CheY, which contains a stand-alone REC domain, and an uncharacterized subfamily composed of proteins containing an N-terminal REC domain and a C-terminal CheY-P phosphatase (CheC) domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381096 [Multi-domain]  Cd Length: 125  Bit Score: 91.30  E-value: 1.61e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798   3 KILIVDD----EKPISDIIKfnmTKEGYEVV-TAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRKTSSVPILM 77
Cdd:cd17541    2 RVLIVDDsavmRKLLSRILE---SDPDIEVVgTARDGEEALEKIKELKPDVITLDIEMPVMDGLEALRRIMAERPTPVVM 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 892137798  78 LSAKDSE-FDKVI-GLELGADDYVTKPFSN---------RELQARVK 113
Cdd:cd17541   79 VSSLTEEgAEITLeALELGAVDFIAKPSGGisldleeiaEELIEKIK 125
REC_DivK-like cd17548
phosphoacceptor receiver (REC) domain of DivK and similar proteins; Caulobacter crescentus ...
 3-113 7.53e-23

phosphoacceptor receiver (REC) domain of DivK and similar proteins; Caulobacter crescentus DivK is an essential response regulator that is involved in the complex phosphorelay pathways controlling both cell division and motility. It localizes cell cycle regulators to specific poles of the cell during division. DivK contains a stand-alone REC domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381100 [Multi-domain]  Cd Length: 115  Bit Score: 89.14  E-value: 7.53e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798   3 KILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRK---TSSVPILMLS 79
Cdd:cd17548    1 KILIVEDNPLNMKLARDLLESAGYEVLEAADGEEALEIARKEKPDLILMDIQLPGMDGLEATRLLKEdpaTRDIPVIALT 80

                         90       100       110
                 ....*....|....*....|....*....|....
gi 892137798  80 AKDSEFDKVIGLELGADDYVTKPFSNRELQARVK 113
Cdd:cd17548   81 AYAMKGDREKILEAGCDGYISKPIDTREFLETVA 114
LytT COG3279
DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction ...
 1-132 1.21e-22

DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction mechanisms];


Pssm-ID: 442510 [Multi-domain]  Cd Length: 235  Bit Score: 92.19  E-value: 1.21e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798   1 MKKILIVDDEKPISDIIKFNMTK-EGYEVVTAF-NGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRKTSSVP-ILM 77
Cdd:COG3279    1 MMKILIVDDEPLARERLERLLEKyPDLEVVGEAsNGEEALELLEEHKPDLVFLDIQMPGLDGFELARQLRELDPPPpIIF 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 892137798  78 LSAKDsefDKVI-GLELGADDYVTKPFSNRELQARVKALLRRSQPMPVDGQEADSK 132
Cdd:COG3279   81 TTAYD---EYALeAFEVNAVDYLLKPIDEERLAKALEKAKERLEAKAAAEASPEEK 133
REC_NarL-like cd17535
phosphoacceptor receiver (REC) domain of NarL (Nitrate/Nitrite response regulator L) family ...
 4-117 3.60e-21

phosphoacceptor receiver (REC) domain of NarL (Nitrate/Nitrite response regulator L) family response regulators; The NarL family is one of the more abundant families of DNA-binding response regulators (RRs). Members of the NarL family contain a REC domain and a helix-turn-helix (HTH) DNA-binding output domain, with a majority of members containing a LuxR-type HTH domain. They function as transcriptional regulators. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381090 [Multi-domain]  Cd Length: 117  Bit Score: 84.87  E-value: 3.60e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798   4 ILIVDDEKPISDIIKFNMTKE-GYEVV-TAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRKT-SSVPILMLSA 80
Cdd:cd17535    1 VLIVDDHPLVREGLRRLLESEpDIEVVgEAADGEEALALLRELRPDVVLMDLSMPGMDGIEALRRLRRRyPDLKVIVLTA 80

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 892137798  81 KDSEFDKVIGLELGADDYVTKPFSNRELQARVKALLR 117
Cdd:cd17535   81 HDDPEYVLRALKAGAAGYLLKDSSPEELIEAIRAVAA 117
Spo0A COG5801
Stage 0 sporulation initiation regulator Spo0A (response regulator, REC-HTH domains) [Cell ...
 1-142 5.42e-21

Stage 0 sporulation initiation regulator Spo0A (response regulator, REC-HTH domains) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444503 [Multi-domain]  Cd Length: 264  Bit Score: 88.32  E-value: 5.42e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798   1 MKKI--LIVDDEKPISDIIK--FNmTKEGYEVV-TAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRKTSSVP- 74
Cdd:COG5801    2 MEKIkvLIADDNREFCELLEeyLS-SQPDMEVVgVAYNGLEALELIEEKKPDVVILDIIMPHLDGLGVLEKLREMNLEKr 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 892137798  75 --ILMLSAKDSEfdKVI--GLELGADDYVTKPFSNRELQARVKALLRRSQPMPVDGQE-ADSKPQPIQIGDLE 142
Cdd:COG5801   81 pkVIMLTAFGQE--DITqrAVELGADYYILKPFDLDVLAERIRQLAGGKAESETSKKKsSPETASVDKARDLE 151
AmiR COG3707
Two-component response regulator, AmiR/NasT family, consists of REC and RNA-binding ...
 1-120 9.30e-21

Two-component response regulator, AmiR/NasT family, consists of REC and RNA-binding antiterminator (ANTAR) domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 442921 [Multi-domain]  Cd Length: 194  Bit Score: 86.16  E-value: 9.30e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798   1 MKKILIVDDEKPISDIIKFNMTKEGYEVVT-AFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRKTSSVPILMLS 79
Cdd:COG3707    3 GLRVLVVDDEPLRRADLREGLREAGYEVVAeAADGEDAVELVRELKPDLVIVDIDMPDRDGLEAARQISEERPAPVILLT 82

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 892137798  80 AKDSEFDKVIGLELGADDYVTKPFSNRELQARVKALLRRSQ 120
Cdd:COG3707   83 AYSDPELIERALEAGVSAYLVKPLDPEDLLPALELALARFR 123
REC_CheY_CheY3 cd19923
phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY3 and similar CheY ...
 3-116 1.54e-20

phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY3 and similar CheY family proteins; CheY family chemotaxis response regulators (RRs) comprise about 17% of bacterial RRs and almost half of all RRs in archaea. This subfamily contains Vibrio cholerae CheY3, Escherichia coli CheY, and similar CheY family RRs. CheY proteins control bacterial motility and participate in signaling phosphorelays and in protein-protein interactions. CheY RRs contain only the REC domain with no output/effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381150 [Multi-domain]  Cd Length: 119  Bit Score: 83.54  E-value: 1.54e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798   3 KILIVDDEKPISDIIKFNMTKEGYEVVT-AFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIR---KTSSVPILML 78
Cdd:cd19923    2 KVLVVDDFSTMRRIIKNLLKELGFNNVEeAEDGVDALEKLKAGGFDFVITDWNMPNMDGLELLKTIRadgALSHLPVLMV 81

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 892137798  79 SAKDSEFDKVIGLELGADDYVTKPFSNRELQARVKALL 116
Cdd:cd19923   82 TAEAKKENVIAAAQAGVNNYIVKPFTAATLKEKLEKIF 119
PRK11361 PRK11361
acetoacetate metabolism transcriptional regulator AtoC;
3-119 4.17e-20

acetoacetate metabolism transcriptional regulator AtoC;


Pssm-ID: 183099 [Multi-domain]  Cd Length: 457  Bit Score: 87.98  E-value: 4.17e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798   3 KILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRK-TSSVPILMLSAK 81
Cdd:PRK11361   6 RILIVDDEDNVRRMLSTAFALQGFETHCANNGRTALHLFADIHPDVVLMDIRMPEMDGIKALKEMRShETRTPVILMTAY 85

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 892137798  82 DSEFDKVIGLELGADDYVTKPFSNRELqarvKALLRRS 119
Cdd:PRK11361  86 AEVETAVEALRCGAFDYVIKPFDLDEL----NLIVQRA 119
PRK00742 PRK00742
chemotaxis-specific protein-glutamate methyltransferase CheB;
3-135 5.16e-20

chemotaxis-specific protein-glutamate methyltransferase CheB;


Pssm-ID: 234828 [Multi-domain]  Cd Length: 354  Bit Score: 87.13  E-value: 5.16e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798   3 KILIVDD----EKPISDIIkfnmTKE-GYEVV-TAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRKTSSVPIL 76
Cdd:PRK00742   5 RVLVVDDsafmRRLISEIL----NSDpDIEVVgTAPDGLEAREKIKKLNPDVITLDVEMPVMDGLDALEKIMRLRPTPVV 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 892137798  77 MLSA---KDSE--FDkviGLELGADDYVTKPFSN---------RELQARVKAL----LRRSQPMPVDGQEADSKPQP 135
Cdd:PRK00742  81 MVSSlteRGAEitLR---ALELGAVDFVTKPFLGislgmdeykEELAEKVRAAararVRALPPRAAAAARAAAAAPA 154
REC_Ycf29 cd19927
phosphoacceptor receiver (REC) domain of probable transcriptional regulator Ycf29; Ycf29 is a ...
 4-102 1.24e-19

phosphoacceptor receiver (REC) domain of probable transcriptional regulator Ycf29; Ycf29 is a probable response regulator of a two-component system (TCS), typically consisting a sensor and a response regulator, that functions in adaptation to changing environments. Processes regulated by TCSs in bacteria include sporulation, pathogenicity, virulence, chemotaxis, and membrane transport. Ycf29 contains an N-terminal REC domain and a LuxR-type helix-turn-helix DNA-binding output domain. REC domains function as phosphorylation-mediated switches within RRs, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381154 [Multi-domain]  Cd Length: 102  Bit Score: 80.50  E-value: 1.24e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798   4 ILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRKT---SSVPILMLSA 80
Cdd:cd19927    1 ILLVDDDPGIRLAVKDYLEDQGFTVIAASNGLEALDLLNQYIPDLIISDIIMPGVDGYSLLGKLRKNadfDTIPVIFLTA 80

                         90       100
                 ....*....|....*....|..
gi 892137798  81 KDSEFDKVIGLELGADDYVTKP 102
Cdd:cd19927   81 KGMTSDRIKGYNAGCDGYLSKP 102
REC_2_GGDEF cd17544
second phosphoacceptor receiver (REC) domain of uncharacterized GGDEF domain proteins; This ...
 3-112 2.01e-19

second phosphoacceptor receiver (REC) domain of uncharacterized GGDEF domain proteins; This family is composed of uncharacterized PleD-like response regulators that contain two N-terminal REC domains and a C-terminal diguanylate cyclase output domain with the characteristic GGDEF motif at the active site. Unlike PleD which contains a REC-like adaptor domain, the second REC domain of these uncharacterized GGDEF domain proteins, described in this model, contains characteristic metal-binding and active site residues. PleD response regulators are global regulators of cell metabolism in some important human pathogens. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381098 [Multi-domain]  Cd Length: 122  Bit Score: 80.64  E-value: 2.01e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798   3 KILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEaEQPDI--IILDLMLPEIDGLEVAKTIRKTSS---VPILM 77
Cdd:cd17544    2 KVLVVDDSATSRNHLRALLRRHNFQVLEAANGQEALEVLE-QHPDIklVITDYNMPEMDGFELVREIRKKYSrdqLAIIG 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 892137798  78 LSAKDS-----EFdkvigLELGADDYVTKPFSNRELQARV 112
Cdd:cd17544   81 ISASGDnalsaRF-----IKAGANDFLTKPFLPEEFYCRV 115
CadC1 COG3710
DNA-binding winged helix-turn-helix (wHTH) domain [Transcription];
134-228 1.00e-18

DNA-binding winged helix-turn-helix (wHTH) domain [Transcription];


Pssm-ID: 442924 [Multi-domain]  Cd Length: 106  Bit Score: 78.41  E-value: 1.00e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798 134 QPIQIGDLEIVPDAYVAKKYGEELDLTHREFELLYHLASHTGQVITREHLLETVWGyDYFGDVRTVDVTVRRLREKIEDT 213
Cdd:COG3710    1 MRYRFGDFRLDPARRELLRDGEPVRLSPRAFDLLLLLLEHPGRVVSRDELLAAVWP-GRVVSDNSLTQAISRLRKALGDD 79

                         90
                 ....*....|....*
gi 892137798 214 PSRPEYILTRRGVGY 228
Cdd:COG3710   80 GLEPRLIRTVPRRGY 94
COG4567 COG4567
DNA-binding response regulator, ActR/RegA family, consists of REC and Fis-type HTH domains ...
 2-131 1.13e-18

DNA-binding response regulator, ActR/RegA family, consists of REC and Fis-type HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443624 [Multi-domain]  Cd Length: 177  Bit Score: 79.96  E-value: 1.13e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798   2 KKILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRKTS-SVPILMLSA 80
Cdd:COG4567    5 RSLLLVDDDEAFARVLARALERRGFEVTTAASVEEALALLEQAPPDYAVLDLRLGDGSGLDLIEALRERDpDARIVVLTG 84

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 892137798  81 KDSEFDKVIGLELGADDYVTKPFSNRELQArvkALLRRSQPMPVDGQEADS 131
Cdd:COG4567   85 YASIATAVEAIKLGADDYLAKPADADDLLA---ALERAEGDAPAPPENPMS 132
REC_RegA-like cd17563
phosphoacceptor receiver (REC) domain of photosynthetic apparatus regulatory protein RegA; ...
 2-110 3.83e-18

phosphoacceptor receiver (REC) domain of photosynthetic apparatus regulatory protein RegA; Rhodobacter sphaeroides RegA, also called response regulator PrrA, is the DNA binding regulatory protein of a redox-responsive two-component regulatory system RegB/RegA that is involved in transactivating anaerobic expression of the photosynthetic apparatus. It contains a REC domain and a DNA-binding helix-turn-helix output domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381111 [Multi-domain]  Cd Length: 112  Bit Score: 76.71  E-value: 3.83e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798   2 KKILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRKTS-SVPILMLSA 80
Cdd:cd17563    1 KSLLLVDDDEVFAERLARALERRGFEVETAHSVEEALALAREEKPDYAVLDLRLGGDSGLDLIPPLRALQpDARIVVLTG 80

                         90       100       110
                 ....*....|....*....|....*....|
gi 892137798  81 KDSEFDKVIGLELGADDYVTKPFSNRELQA 110
Cdd:cd17563   81 YASIATAVEAIKLGADDYLAKPADADEILA 110
REC_NtrC1-like cd17572
phosphoacceptor receiver (REC) domain of nitrogen regulatory protein C 1 (NtrC1) from Aquifex ...
 4-119 4.67e-18

phosphoacceptor receiver (REC) domain of nitrogen regulatory protein C 1 (NtrC1) from Aquifex aeolicus and similar NtrC family response regulators; NtrC family proteins are transcriptional regulators that have REC, AAA+ ATPase/sigma-54 interaction, and DNA-binding output domains. This subfamily of NtrC proteins include Aquifex aeolicus NtrC1 and Vibrio quorum-sensing signal integrator LuxO. The N-terminal REC domain of NtrC proteins regulate the activity of the protein and its phosphorylation controls the AAA+ domain oligomerization, while the central AAA+ domain participates in nucleotide binding, hydrolysis, oligomerization, and sigma54 interaction. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381114 [Multi-domain]  Cd Length: 121  Bit Score: 76.85  E-value: 4.67e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798   4 ILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRKTS-SVPILMLSAKD 82
Cdd:cd17572    1 VLLVEDSPSLAALYQEYLSDEGYKVTHVETGKEALAFLSDQPPDVVLLDLKLPDMSGMEILKWIQERSlPTSVIVITAHG 80

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 892137798  83 SEFDKVIGLELGADDYVTKPFSNRELQARV-KALLRRS 119
Cdd:cd17572   81 SVDIAVEAMRLGAYDFLEKPFDADRLRVTVrNALKHRK 118
REC_PdtaR-like cd19932
phosphoacceptor receiver (REC) domain of PdtaR and similar proteins; This subfamily includes ...
 2-108 1.12e-17

phosphoacceptor receiver (REC) domain of PdtaR and similar proteins; This subfamily includes Mycobacterium tuberculosis PdtaR, also called Rv1626, and similar proteins containing a REC domain and an ANTAR (AmiR and NasR transcription antitermination regulators) RNA-binding output domain. PdtaR is a response regulator that acts at the level of transcriptional antitermination and is a member of the PdtaR/PdtaS two-component regulatory system. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381159 [Multi-domain]  Cd Length: 118  Bit Score: 75.91  E-value: 1.12e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798   2 KKILIVDDEKPISDIIKFNMTKEGYEVV-TAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRKTSSVPILMLSA 80
Cdd:cd19932    1 VRVLIAEDEALIRMDLREMLEEAGYEVVgEASDGEEAVELAKKHKPDLVIMDVKMPRLDGIEAAKIITSENIAPIVLLTA 80

                         90       100
                 ....*....|....*....|....*....
gi 892137798  81 -KDSEFDKVIGlELGADDYVTKPFSNREL 108
Cdd:cd19932   81 ySQQDLVERAK-EAGAMAYLVKPFSESDL 108
REC_PatA-like cd17602
phosphoacceptor receiver (REC) domain of PatA and similar domains; Nostoc sp. (or Anabaena sp.) ...
 4-102 1.28e-17

phosphoacceptor receiver (REC) domain of PatA and similar domains; Nostoc sp. (or Anabaena sp.) PatA is necessary for proper patterning of heterocysts along filaments. PatA contains phosphoacceptor REC domain at its C-terminus and an N-terminal PATAN (PatA N-terminus) domain, which was proposed in a bioinformatics study to mediate protein-protein interactions. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays. Some members of this group may have an inactive REC domain, lacking canonical metal-binding and active site residues.


Pssm-ID: 381129 [Multi-domain]  Cd Length: 102  Bit Score: 75.10  E-value: 1.28e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798   4 ILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRKTS---SVPILMLSA 80
Cdd:cd17602    1 VACVDDRPSIQKMIEYFLEKQGFRVVVIDDPLRALTTLLNSKPDLILIDIDMPDLDGYELCSLLRKSSalkDTPIIMLTG 80

                         90       100
                 ....*....|....*....|..
gi 892137798  81 KDSEFDKVIGLELGADDYVTKP 102
Cdd:cd17602   81 KDGLVDRIRAKMAGASGYLTKP 102
REC_Rcp-like cd17557
phosphoacceptor receiver (REC) domain of cyanobacterial phytochrome response regulator Rcp and ...
 3-115 1.44e-17

phosphoacceptor receiver (REC) domain of cyanobacterial phytochrome response regulator Rcp and similar domains; This family is composed of response regulators (RRs) that are members of phytochrome-associated, light-sensing two-component signal transduction pathways such as Synechocystis sp. Rcp1, Tolypothrix sp. RcpA, and Agrobacterium tumefaciens bacteriophytochrome response regulator AtBRR. They are stand-alone RRs containing only a REC domain with no output/effector domain. The REC domain itself functions as an effector domain. Also included in this family us Methanosaeta harundinacea methanogenesis regulatory protein FilR2, also a stand-alone RR. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381108 [Multi-domain]  Cd Length: 129  Bit Score: 75.92  E-value: 1.44e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798   3 KILIVDDEKPISDIIKFNMTKEG--YEVVTAFNGREAL-------EQFEAEQPDIIILDLMLPEIDGLEVAKTIRK---T 70
Cdd:cd17557    1 TILLVEDNPGDAELIQEAFKEAGvpNELHVVRDGEEALdflrgegEYADAPRPDLILLDLNMPRMDGFEVLREIKAdpdL 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 892137798  71 SSVPILMLSAKDSEFDKVIGLELGADDYVTKPFSNRELQARVKAL 115
Cdd:cd17557   81 RRIPVVVLTTSDAEEDIERAYELGANSYIVKPVDFEEFVEAIRSL 125
REC_CheV-like cd19924
phosphoacceptor receiver (REC) domain of chemotaxis protein CheV and similar proteins; This ...
 4-102 5.45e-17

phosphoacceptor receiver (REC) domain of chemotaxis protein CheV and similar proteins; This subfamily includes the REC domains of Bacillus subtilis chemotaxis protein CheV, Myxococcus xanthus gliding motility regulatory protein FrzE, and similar proteins. CheV is a hybrid protein with an N-terminal CheW-like domain and a C-terminal CheY-like REC domain. The CheV pathway is one of three systems employed by B. subtilis for sensory adaptation that contribute to chemotaxis. It is involved in the transmission of sensory signals from chemoreceptors to flagellar motors. Together with CheW, it is involved in the coupling of methyl-accepting chemoreceptors to the central two-component histidine kinase CheA. FrzE is a hybrid sensor histidine kinase/response regulator that is part of the Frz pathway that controls cell reversal frequency to support directional motility during swarming and fruiting body formation. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381151 [Multi-domain]  Cd Length: 111  Bit Score: 73.95  E-value: 5.45e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798   4 ILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEA---------EQPDIIILDLMLPEIDGLEVAKTIRKT---S 71
Cdd:cd19924    1 ILVVDDSPTARKQLRDLLKNLGFEIAEAVDGEEALNKLENlakegndlsKELDLIITDIEMPKMDGYELTFELRDDprlA 80

                         90       100       110
                 ....*....|....*....|....*....|.
gi 892137798  72 SVPILMLSAKDSEFDKVIGLELGADDYVTKP 102
Cdd:cd19924   81 NIPVILNSSLSGEFSRARGKKVGADAYLAKF 111
spore_0_A TIGR02875
sporulation transcription factor Spo0A; Spo0A, the stage 0 sporulation protein A, is a ...
 3-115 6.72e-17

sporulation transcription factor Spo0A; Spo0A, the stage 0 sporulation protein A, is a transcription factor critical for the initiation of sporulation. It contains a response regulator receiver domain (pfam00072). In Bacillus subtilis, it works together with response regulator Spo0F and the phosphotransferase Spo0B, both of which are missing from at least some sporulating species and thus not part of the endospore forming bacteria minimal gene set. Spo0A, however, is universal among endospore-forming species. [Cellular processes, Sporulation and germination]


Pssm-ID: 131922 [Multi-domain]  Cd Length: 262  Bit Score: 77.14  E-value: 6.72e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798    3 KILIVDDEKPISDIIK-FNMTKEGYEVV-TAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIR--KTSSVP-ILM 77
Cdd:TIGR02875   4 RIVIADDNKEFCNLLKeYLAAQPDMEVVgVAHNGVDALELIKEQQPDVVVLDIIMPHLDGIGVLEKLNeiELSARPrVIM 83

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 892137798   78 LSAKDSEFDKVIGLELGADDYVTKPFSNRELQARVKAL 115
Cdd:TIGR02875  84 LSAFGQEKITQRAVALGADYYVLKPFDLEILAARIRQL 121
REC_typeB_ARR-like cd17584
phosphoacceptor receiver (REC) domain of type B Arabidopsis response regulators (ARRs) and ...
 4-110 7.92e-17

phosphoacceptor receiver (REC) domain of type B Arabidopsis response regulators (ARRs) and similar domains; Type-B ARRs (Arabidopsis response regulators) are a class of MYB-type transcription factors that act as major players in the transcriptional activation of cytokinin-responsive genes. They directly regulate the expression of type-A ARR genes and other downstream target genes. Cytokinin is a plant hormone implicated in many growth and development processes including shoot organogenesis, leaf senescence, sink/source relationships, vascular development, lateral bud release, and photomorphogenic development. Cytokinin signaling involves a phosphorelay cascade by histidine kinase receptors (AHKs), histidine phosphotransfer proteins (AHPs) and downstream ARRs. ARRs are divided into two groups, type-A and -B, according to their sequence and domain structure. Type-B ARRs contain a receiver (REC) domain and a large C-terminal extension that has characteristics of an effector or output domain, with a Myb-like DNA binding domain referred to as the GARP domain. The GARP domain is a motif specific to plant transcription factors. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381121 [Multi-domain]  Cd Length: 115  Bit Score: 73.43  E-value: 7.92e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798   4 ILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFE--AEQPDIIILDLMLPEIDGLEVAKTIRKTSSVPILMLSAK 81
Cdd:cd17584    1 VLVVDDDPTCLAILKRMLLRCGYQVTTCTDAEEALSMLRenKDEFDLVITDVHMPDMDGFEFLELIRLEMDLPVIMMSAD 80

                         90       100
                 ....*....|....*....|....*....
gi 892137798  82 DSEFDKVIGLELGADDYVTKPFSNRELQA 110
Cdd:cd17584   81 GSTSTVMKGLAHGACDYLLKPVSIEDLKN 109
REC_Spo0F-like cd17553
phosphoacceptor receiver (REC) domain of Spo0F and similar domains; Spo0F, a stand-alone ...
 2-116 1.43e-16

phosphoacceptor receiver (REC) domain of Spo0F and similar domains; Spo0F, a stand-alone response regulator containing only a REC domain with no output/effector domain, controls sporulation in Bacillus subtilis through the exchange of a phosphoryl group. Bacillus subtilis forms spores when conditions for growth become unfavorable. The initiation of sporulation is controlled by a phosphorelay (an expanded version of the two-component system) that consists of four main components: a histidine kinase (KinA), a secondary messenger (Spo0F), a phosphotransferase (Spo0B), and a transcription factor (Spo0A). REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381105 [Multi-domain]  Cd Length: 117  Bit Score: 72.97  E-value: 1.43e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798   2 KKILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRK-TSSVPILMLSA 80
Cdd:cd17553    1 EKILIVDDQYGIRILLNEVFNKEGYQTFQAANGLQALDIVTKERPDLVLLDMKIPGMDGIEILKRMKViDENIRVIIMTA 80

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 892137798  81 KdSEFDKVI-GLELGADDYVTKPFSNRELQARVKALL 116
Cdd:cd17553   81 Y-GELDMIQeSKELGALTHFAKPFDIDEIRDAVKKYL 116
REC smart00448
cheY-homologous receiver domain; CheY regulates the clockwise rotation of E. coli flagellar ...
 2-56 2.29e-16

cheY-homologous receiver domain; CheY regulates the clockwise rotation of E. coli flagellar motors. This domain contains a phosphoacceptor site that is phosphorylated by histidine kinase homologues.


Pssm-ID: 214668 [Multi-domain]  Cd Length: 55  Bit Score: 70.68  E-value: 2.29e-16
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 892137798     2 KKILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLP 56
Cdd:smart00448   1 MRILVVDDDPLLRELLKALLEKEGYEVDEATDGEEALELLKEEKPDLILLDIMMP 55
REC_LytTR_AlgR-like cd17532
phosphoacceptor receiver (REC) domain of LytTR/AlgR family response regulators similar to AlgR; ...
 4-117 8.28e-16

phosphoacceptor receiver (REC) domain of LytTR/AlgR family response regulators similar to AlgR; Members of the LytTR/AlgR family of response regulators contain a REC domain and a unique LytTR DNA-binding output domain that lacks the helix-turn-helix motif and consists mostly of beta-strands. Transcriptional regulators with the LytTR-type output domains are involved in biosynthesis of extracellular polysaccharides, fimbriation, expression of exoproteins, including toxins, and quorum sensing. Included in this AlgR-like group of LytTR/AlgR family response regulators are Streptococcus agalactiae sensory transduction protein LytR, Pseudomonas aeruginosa positive alginate biosynthesis regulatory protein AlgR, Bacillus subtilis sensory transduction protein LytT, and Escherichia coli transcriptional regulatory protein BtsR, which are members of two-component regulatory systems. LytR and LytT are components of regulatory systems that regulate genes involved in cell wall metabolism. AlgR positively regulates the algD gene, which codes for a GDP-mannose dehydrogenase, a key enzyme in the alginate biosynthesis pathway. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381087 [Multi-domain]  Cd Length: 118  Bit Score: 71.03  E-value: 8.28e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798   4 ILIVDDEKPISDIIKFNMTKEGY--EVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRKTSSVP-ILMLSA 80
Cdd:cd17532    1 ALIVDDEPLAREELRYLLEEHPDieIVGEAENGEEALEAIEELKPDVVFLDIQMPGLDGLELAKKLSKLAKPPlIVFVTA 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 892137798  81 KDsEFdKVIGLELGADDYVTKPFSNRELQ---ARVKALLR 117
Cdd:cd17532   81 YD-EY-AVEAFELNAVDYLLKPFSEERLAealAKLRKRLS 118
REC_HupR-like cd17569
phosphoacceptor receiver (REC) domain of hydrogen uptake protein regulator (HupR) and similar ...
 2-117 1.03e-15

phosphoacceptor receiver (REC) domain of hydrogen uptake protein regulator (HupR) and similar domains; This family is composed of mostly uncharacterized response regulators with similarity to the REC domains of response regulator components of two-component systems that regulates hydrogenase activity, including HupR and HoxA. HupR is part of the HupT/HupR system that controls the synthesis of the membrane-bound [NiFe]hydrogenase, HupSL, of the photosynthetic bacterium Rhodobacter capsulatus. It contains an N-terminal REC domain, a central sigma-54 interaction domain that lacks ATPase activity, and a C-terminal DNA-binding domain. Members of this family contain a REC domain and various output domains including the cyclase homology domain (CHD) and the c-di-GMP phosphodiesterase domains, HD-GYP and EAL. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381113 [Multi-domain]  Cd Length: 118  Bit Score: 70.51  E-value: 1.03e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798   2 KKILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRKTSSVPI-LMLSA 80
Cdd:cd17569    1 PTILLVDDEPNILKALKRLLRREGYEVLTATSGEEALEILKQEPVDVVISDQRMPGMDGAELLKRVRERYPDTVrILLTG 80

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 892137798  81 kDSEFDKVIGL--ELGADDYVTKPFSNRELQARVKALLR 117
Cdd:cd17569   81 -YADLDAAIEAinEGEIYRFLTKPWDDEELKETIRQALE 118
REC_Spo0A cd17561
phosphoacceptor receiver (REC) domain of Spo0A; Spo0A is a response regulator of the ...
 3-103 2.29e-15

phosphoacceptor receiver (REC) domain of Spo0A; Spo0A is a response regulator of the phosphorelay system in the early stage of spore formation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress and may act in the with sigma factor spo0H to control the expression of some genes that are critical to the sporulation process. Spo0A contains a regulatory N-terminal REC domain and a C-terminal DNA-binding transcription activation domain as its effector/output domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381109 [Multi-domain]  Cd Length: 108  Bit Score: 69.56  E-value: 2.29e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798   3 KILIVDDEKPISDII-KFNMTKEGYEVV-TAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRKT--SSVP-ILM 77
Cdd:cd17561    3 KVLIADDNREFVQLLeEYLNSQPDMEVVgVAHNGQEALELIEEKEPDVLLLDIIMPHLDGIGVLEKLRRMrlEKRPkIIM 82

                         90       100
                 ....*....|....*....|....*.
gi 892137798  78 LSAKDSEFDKVIGLELGADDYVTKPF 103
Cdd:cd17561   83 LTAFGQEDITQRAVELGASYYILKPF 108
PRK10365 PRK10365
sigma-54-dependent response regulator transcription factor ZraR;
4-125 5.51e-15

sigma-54-dependent response regulator transcription factor ZraR;


Pssm-ID: 182412 [Multi-domain]  Cd Length: 441  Bit Score: 73.14  E-value: 5.51e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798   4 ILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRKTS-SVPILMLSAKD 82
Cdd:PRK10365   8 ILVVDDDISHCTILQALLRGWGYNVALANSGRQALEQVREQVFDLVLCDVRMAEMDGIATLKEIKALNpAIPVLIMTAYS 87

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 892137798  83 SEFDKVIGLELGADDYVTKPFSNRELQARVKALLRRSQPMPVD 125
Cdd:PRK10365  88 SVETAVEALKTGALDYLIKPLDFDNLQATLEKALAHTHSIDAE 130
PRK12555 PRK12555
chemotaxis-specific protein-glutamate methyltransferase CheB;
3-117 8.96e-15

chemotaxis-specific protein-glutamate methyltransferase CheB;


Pssm-ID: 237135 [Multi-domain]  Cd Length: 337  Bit Score: 72.22  E-value: 8.96e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798   3 KILIVDDEKPISDIIKFNMTKE-GYEVV-TAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRKTSSVPILMLSA 80
Cdd:PRK12555   2 RIGIVNDSPLAVEALRRALARDpDHEVVwVATDGAQAVERCAAQPPDVILMDLEMPRMDGVEATRRIMAERPCPILIVTS 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 892137798  81 -KDSEFDKVI-GLELGADDYVTKPFSN--RELQARVKALLR 117
Cdd:PRK12555  82 lTERNASRVFeAMGAGALDAVDTPTLGigAGLEEYAAELLA 122
FixJ COG4566
DNA-binding response regulator, FixJ family, consists of REC and HTH domains [Signal ...
 4-120 1.02e-14

DNA-binding response regulator, FixJ family, consists of REC and HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443623 [Multi-domain]  Cd Length: 196  Bit Score: 69.74  E-value: 1.02e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798   4 ILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRKT-SSVPILMLSAKd 82
Cdd:COG4566    2 VYIVDDDEAVRDSLAFLLESAGLRVETFASAEAFLAALDPDRPGCLLLDVRMPGMSGLELQEELAARgSPLPVIFLTGH- 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 892137798  83 sefdkviG--------LELGADDYVTKPFSNRELQARVKALLRRSQ 120
Cdd:COG4566   81 -------GdvpmavraMKAGAVDFLEKPFDDQALLDAVRRALARDR 119
PRK10610 PRK10610
chemotaxis protein CheY;
3-118 1.08e-14

chemotaxis protein CheY;


Pssm-ID: 170568 [Multi-domain]  Cd Length: 129  Bit Score: 68.46  E-value: 1.08e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798   3 KILIVDDEKPISDIIKfNMTKE-GYE-VVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRK---TSSVPILM 77
Cdd:PRK10610   7 KFLVVDDFSTMRRIVR-NLLKElGFNnVEEAEDGVDALNKLQAGGFGFVISDWNMPNMDGLELLKTIRAdgaMSALPVLM 85

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 892137798  78 LSAKDSEFDKVIGLELGADDYVTKPFSNRELQARVKALLRR 118
Cdd:PRK10610  86 VTAEAKKENIIAAAQAGASGYVVKPFTAATLEEKLNKIFEK 126
REC_DctD-like cd17549
phosphoacceptor receiver (REC) domain of C4-dicarboxylic acid transport protein D (DctD) and ...
 4-119 1.32e-14

phosphoacceptor receiver (REC) domain of C4-dicarboxylic acid transport protein D (DctD) and similar proteins; C4-dicarboxylic acid transport protein D (DctD) is part of the two-component regulatory system DctB/DctD, which regulates C4-dicarboxylate transport via regulation of expression of the dctPQM operon and dctA. It is an activator of sigma(54)-RNA polymerase holoenzyme that uses the energy released from ATP hydrolysis to stimulate the isomerization of a closed promoter complex to an open complex capable of initiating transcription. DctD is a member of the NtrC family, characterized by a domain architecture containing an N-terminal REC domain, followed by a central sigma-54 interaction/ATPase domain, and a C-terminal DNA binding domain. The ability of the central domain to hydrolyze ATP and thus to interact effectively with a complex of RNA polymerase, sigma54, and promoter, is controlled by the phosphorylation status of the REC domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381101 [Multi-domain]  Cd Length: 130  Bit Score: 67.90  E-value: 1.32e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798   4 ILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRKT-SSVPILMLS--- 79
Cdd:cd17549    1 VLLVDDDADVREALQQTLELAGFRVRAFADAEEALAALSPDFPGVVISDIRMPGMDGLELLAQIRELdPDLPVILITghg 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 892137798  80 ----AkdsefdkVIGLELGADDYVTKPFSNRELQARVK-ALLRRS 119
Cdd:cd17549   81 dvpmA-------VEAMRAGAYDFLEKPFDPERLLDVVRrALEKRR 118
REC_FixJ cd17537
phosphoacceptor receiver (REC) domain of FixJ family response regulators; FixJ family response ...
 4-114 1.42e-14

phosphoacceptor receiver (REC) domain of FixJ family response regulators; FixJ family response regulators contain an N-terminal receiver domain (REC) and a C-terminal LuxR family helix-turn-helix (HTH) DNA-binding output domain. The Sinorhizobium meliloti two-component system FixL/FixJ regulates nitrogen fixation in response to oxygen during symbiosis. Under microaerobic conditions, the kinase FixL phosphorylates the response regulator FixJ resulting in the regulation of nitrogen fixation genes such as nifA and fixK. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381092 [Multi-domain]  Cd Length: 116  Bit Score: 67.62  E-value: 1.42e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798   4 ILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRKT-SSVPILMLSAKD 82
Cdd:cd17537    3 VYVVDDDEAVRDSLAFLLRSVGLAVKTFTSASAFLAAAPPDQPGCLVLDVRMPGMSGLELQDELLARgSNIPIIFITGHG 82

                         90       100       110
                 ....*....|....*....|....*....|..
gi 892137798  83 SEFDKVIGLELGADDYVTKPFSNRELQARVKA 114
Cdd:cd17537   83 DVPMAVEAMKAGAVDFLEKPFRDQVLLDAIEQ 114
REC_NtrC cd19919
phosphoacceptor receiver (REC) domain of DNA-binding transcriptional regulator NtrC; ...
 2-103 2.10e-14

phosphoacceptor receiver (REC) domain of DNA-binding transcriptional regulator NtrC; DNA-binding transcriptional regulator NtrC is also called nitrogen regulation protein NR(I) or nitrogen regulator I (NRI). It contains an N-terminal receiver (REC) domain, followed by a sigma-54 interaction domain, and a C-terminal helix-turn-helix DNA-binding domain. It is part of the two-component regulatory system NtrB/NtrC, which controls expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. DNA-binding response regulator NtrC is phosphorylated by NtrB; phosphorylation of the N-terminal REC domain activates the central sigma-54 interaction domain and leads to the transcriptional activation from promoters that require sigma(54)-containing RNA polymerase. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381146 [Multi-domain]  Cd Length: 116  Bit Score: 67.30  E-value: 2.10e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798   2 KKILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIR-KTSSVPILMLSA 80
Cdd:cd19919    1 KTVWIVDDDSSIRWVLERALAGAGLTVTSFENAQEALAALASSQPDVLISDIRMPGMDGLALLAQIKqRHPDLPVIIMTA 80

                         90       100
                 ....*....|....*....|....
gi 892137798  81 KdSEFDK-VIGLELGADDYVTKPF 103
Cdd:cd19919   81 H-SDLDSaVSAYQGGAFEYLPKPF 103
PRK15115 PRK15115
response regulator GlrR; Provisional
 4-121 2.95e-14

response regulator GlrR; Provisional


Pssm-ID: 185070 [Multi-domain]  Cd Length: 444  Bit Score: 71.02  E-value: 2.95e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798   4 ILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRKTS-SVPILMLSAKD 82
Cdd:PRK15115   8 LLLVDDDPGLLKLLGMRLTSEGYSVVTAESGQEALRVLNREKVDLVISDLRMDEMDGMQLFAEIQKVQpGMPVIILTAHG 87

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 892137798  83 SEFDKVIGLELGADDYVTKPFSNRELQARVKALLRRSQP 121
Cdd:PRK15115  88 SIPDAVAATQQGVFSFLTKPVDRDALYKAIDDALEQSAP 126
pleD PRK09581
response regulator PleD; Reviewed
 2-120 7.72e-14

response regulator PleD; Reviewed


Pssm-ID: 236577 [Multi-domain]  Cd Length: 457  Bit Score: 69.93  E-value: 7.72e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798   2 KKILIVDDEKPISDIIKfNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIR---KTSSVPILML 78
Cdd:PRK09581 156 GRILLVDDDVSQAERIA-NILKEEFRVVVVSDPSEALFNAAETNYDLVIVSANFENYDPLRLCSQLRskeRTRYVPILLL 234

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 892137798  79 SAKDSEFDKVIGLELGADDYVTKPFSNRELQARVKALLRRSQ 120
Cdd:PRK09581 235 VDEDDDPRLVKALELGVNDYLMRPIDKNELLARVRTQIRRKR 276
REC_citrate_TCS cd19925
phosphoacceptor receiver (REC) domain of citrate family two-component system response ...
 3-111 2.79e-13

phosphoacceptor receiver (REC) domain of citrate family two-component system response regulators; This family includes Lactobacillus paracasei MaeR, Escherichia coli DcuR and DpiA, Klebsiella pneumoniae CitB, as well as Bacillus DctR, MalR, and CitT. These are all response regulators of two-component systems (TCSs) from the citrate family, and are involved in the transcriptional regulation of genes associated with L-malate catabolism (MaeRK), citrate-specific fermentation (DpiAB, CitAB), plasmid inheritance (DpiAB), anaerobic fumarate respiratory system (DcuRS), and malate transport/utilization (MalKR). REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381152 [Multi-domain]  Cd Length: 118  Bit Score: 64.19  E-value: 2.79e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798   3 KILIVDDEKPISDIIKFNMTK-EGYEVV-TAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRKTS-SVPILMLS 79
Cdd:cd19925    2 NVLIVEDDPMVAEIHRAYVEQvPGFTVIgTAGTGEEALKLLKERQPDLILLDIYLPDGNGLDLLRELRAAGhDVDVIVVT 81

                         90       100       110
                 ....*....|....*....|....*....|...
gi 892137798  80 AkDSEFDKV-IGLELGADDYVTKPFSNRELQAR 111
Cdd:cd19925   82 A-ANDVETVrEALRLGVVDYLIKPFTFERLRQR 113
PRK10693 PRK10693
two-component system response regulator RssB;
31-105 5.92e-13

two-component system response regulator RssB;


Pssm-ID: 182652 [Multi-domain]  Cd Length: 303  Bit Score: 66.55  E-value: 5.92e-13
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 892137798  31 AFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIR-KTSSVPILMLSAKD--SEFDKVigLELGADDYVTKPFSN 105
Cdd:PRK10693   3 AANGVDALELLGGFTPDLIICDLAMPRMNGIEFVEHLRnRGDQTPVLVISATEnmADIAKA--LRLGVQDVLLKPVKD 78
REC_CheC-like cd17593
phosphoacceptor receiver (REC) domain of uncharacterized response regulators containing a CheC ...
 2-118 9.23e-13

phosphoacceptor receiver (REC) domain of uncharacterized response regulators containing a CheC domain; This subfamily is composed of uncharacterized proteins containing an N-terminal REC domain and a C-terminal CheC domain that may function as the output/effector domain of a response regulator. CheC is a CheY-P phosphatase, affecting the level of phosphorylated CheY which controls the sense of flagella rotation and determine swimming behavior of chemotactic bacteria. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381124 [Multi-domain]  Cd Length: 117  Bit Score: 62.94  E-value: 9.23e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798   2 KKILIVDDEKPI-SDIIKFNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRKTS-SVPILMLS 79
Cdd:cd17593    1 MKVLICDDSSMArKQLARALPADWDVEITFAENGEEALEILREGRIDVLFLDLTMPVMDGYEVLEALPVEQlETKVIVVS 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 892137798  80 A--KDSEFDKVigLELGADDYVTKPFSnrelQARVKALLRR 118
Cdd:cd17593   81 GdvQPEAKERV--LELGALAFLKKPFD----PEKLAQLLEE 115
psREC-like_D2_PleD cd17539
REC-like adaptor domain (D2) of response regulator PleD; PleD contains a REC domain (D1) with ...
 4-118 1.13e-12

REC-like adaptor domain (D2) of response regulator PleD; PleD contains a REC domain (D1) with the phosphorylatable aspartate, a pseudo receiver (psREC)-like adaptor domain (D2), and the enzymatic diguanylate cyclase (DGC) domain, also called the GGDEF domain according to a conserved sequence motif, as its output domain. The GGDEF-containing PleD response regulators are global regulators of cell metabolism in some important human pathogens. This model describes the REC-like adaptor domain D2 of PleD, which is an inactive domain.


Pssm-ID: 381094 [Multi-domain]  Cd Length: 124  Bit Score: 62.72  E-value: 1.13e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798   4 ILIVDDEKPISDIIkFNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIR---KTSSVPILMLSA 80
Cdd:cd17539    1 VLLVDDRPSSAERI-AAMLSSEHEVVVEADPDEALFRAAEGPFDLVIVSLALEDFDGLRLCSQLRsleRTRQLPILAVAD 79

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 892137798  81 KDSEFDKVIGLELGADDYVTKPFSNRELQARVKALLRR 118
Cdd:cd17539   80 PGDRGRLIRALEIGVNDYLVRPIDPNELLARVRTQIRR 117
REC_HP-RR-like cd17573
phosphoacceptor receiver (REC) domain of orphan response regulator HP-RR and similar proteins; ...
 4-112 1.14e-12

phosphoacceptor receiver (REC) domain of orphan response regulator HP-RR and similar proteins; Helicobacter pylori response regulator hp1043 (HP-RR) is an orphan response regulator which is phosphorylation-independent and is essential for growth. HP-RR functions as a cell growth-associated regulator in the absence of post-translational modification. Members of this subfamily contain REC and DNA-binding output domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381115 [Multi-domain]  Cd Length: 110  Bit Score: 62.45  E-value: 1.14e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798   4 ILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIR-KTSSVPILMLSAKD 82
Cdd:cd17573    1 ILLIEDDSTLGKEISKGLNEKGYQADVAESLKDGEYYIDIRNYDLVLVSDKLPDGNGLSIVSRIKeKHPSIVVIVLSDNP 80

                         90       100       110
                 ....*....|....*....|....*....|
gi 892137798  83 SEFDKVIGLELGADDYVTKPFSNRELQARV 112
Cdd:cd17573   81 KTEQEIEAFKEGADDYIAKPFDFKVLVARI 110
PRK11091 PRK11091
aerobic respiration control sensor protein ArcB; Provisional
 4-142 1.71e-12

aerobic respiration control sensor protein ArcB; Provisional


Pssm-ID: 236842 [Multi-domain]  Cd Length: 779  Bit Score: 66.12  E-value: 1.71e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798   4 ILIVDDekpisdiIKFNMT-------KEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRKTSSV--- 73
Cdd:PRK11091 528 ILLVED-------IELNVIvarsvleKLGNSVDVAMTGKEALEMFDPDEYDLVLLDIQLPDMTGLDIARELRERYPRedl 600

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 892137798  74 -PILMLSA---KDS-EFdkvigLELGADDYVTKPFSNRELQARVKALLRRSQPMPVDGQEADSKPQPIQIGDLE 142
Cdd:PRK11091 601 pPLVALTAnvlKDKkEY-----LDAGMDDVLSKPLSVPALTAMIKKFWDTQDDEESTVTTEESSKANEALLDIP 669
CitB COG2197
DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal ...
 1-67 1.76e-12

DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 441799 [Multi-domain]  Cd Length: 131  Bit Score: 62.22  E-value: 1.76e-12
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 892137798   1 MKKILIVDDEKPISDIIKFNMTKE-GYEVV-TAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTI 67
Cdd:COG2197    1 MIRVLIVDDHPLVREGLRALLEAEpDIEVVgEAADGEEALELLEELRPDVVLLDIRMPGMDGLEALRRL 69
PRK15347 PRK15347
two component system sensor kinase;
3-187 6.56e-12

two component system sensor kinase;


Pssm-ID: 237951 [Multi-domain]  Cd Length: 921  Bit Score: 64.66  E-value: 6.56e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798   3 KILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRKT-----SSVPILM 77
Cdd:PRK15347 692 QILLVDDVETNRDIIGMMLVELGQQVTTAASGTEALELGRQHRFDLVLMDIRMPGLDGLETTQLWRDDpnnldPDCMIVA 771

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798  78 LSAKDSEFDKVIGLELGADDYVTKPFS----NRELQARVKALLRRSQPMpvdgQEADSKPQPIqigdLEIVpdayvakky 153
Cdd:PRK15347 772 LTANAAPEEIHRCKKAGMNHYLTKPVTlaqlARALELAAEYQLLRGIEL----SPQDSSCSPL----LDTD--------- 834

                        170       180       190
                 ....*....|....*....|....*....|....
gi 892137798 154 geELDLTHREFELLYHLASHTGQVITREHLLETV 187
Cdd:PRK15347 835 --DMALNSKLYQSLLLLLAQIEQAVENQEVLSQL 866
REC_CpdR_CckA-like cd18160
phosphoacceptor receiver (REC) domain of Brucella abortus CpdR and CckA, and similar domains; ...
 3-79 7.87e-12

phosphoacceptor receiver (REC) domain of Brucella abortus CpdR and CckA, and similar domains; Two-component systems (TCSs), consisting of a sensor and a response regulator, are used by bacteria to adapt to changing environments. Processes regulated by TCSs in bacteria include sporulation, pathogenicity, virulence, chemotaxis and membrane transport. Response regulators share the common phosphoacceptor REC domain and differ output domains such as DNA, RNA, ligand, and protein-binding, or enzymatic domain. CpdR is a stand-alone REC protein. CckA is a sensor histidine kinase containing N-terminal PAS domains and a C-terminal REC domain. CpdR and CckA are components of a regulatory phosphorelay system (composed of CckA, ChpT, CtrA and CpdR) that controls Brucella abortus cell growth, division, and intracellular survival inside mammalian host cells. CckA autophosphorylates in the presence of ATP and transfers a phosphoryl group to the conserved aspartic acid residue on its C-terminal REC domain, which is relayed to the ChpT phosphotransferase. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381144 [Multi-domain]  Cd Length: 103  Bit Score: 59.82  E-value: 7.87e-12
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 892137798   3 KILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAEQP-DIIILDLMLPEIDGLEVAKTIRKTS-SVPILMLS 79
Cdd:cd18160    1 TILLADDEPSVRKFIVTTLKKAGYAVTEAESGAEALEKLQQGKDiDIVVTDIVMPEMDGIELAREARKIDpDVKILFIS 79
REC_PilR cd19926
phosphoacceptor receiver (REC) domain of type 4 fimbriae expression regulatory protein PilR ...
 4-102 1.34e-11

phosphoacceptor receiver (REC) domain of type 4 fimbriae expression regulatory protein PilR and similar proteins; Pseudomonas aeruginosa PilR is the response regulator of the PilS/PilR two-component regulatory system (PilSR TCS) that acts in conjunction with sigma-54 to regulate the expression of type 4 pilus (T4P) major subunit PilA. In addition, the PilSR TCS regulates flagellum-dependent swimming motility and pilus-dependent twitching motility. PilR contains an N-terminal REC domain, a central sigma-54 interaction domain, and a C-terminal Fis-type helix-turn-helix DNA-binding domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381153 [Multi-domain]  Cd Length: 100  Bit Score: 59.09  E-value: 1.34e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798   4 ILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTI-RKTSSVPILMLSAKD 82
Cdd:cd19926    1 VLVVDDEPDIRELLEITLGRMGLDVRSARNVKEARELLASEPYDLCLTDMRLPDGSGLELVQHIqQRLPQTPVAVITAYG 80

                         90       100
                 ....*....|....*....|
gi 892137798  83 SEFDKVIGLELGADDYVTKP 102
Cdd:cd19926   81 SLDTAIEALKAGAFDFLTKP 100
PRK15369 PRK15369
two component system response regulator;
3-113 1.63e-11

two component system response regulator;


Pssm-ID: 185267 [Multi-domain]  Cd Length: 211  Bit Score: 61.63  E-value: 1.63e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798   3 KILIVDDEKPISDIIKfNM--TKEGYEVVTAF-NGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRKT-SSVPILML 78
Cdd:PRK15369   5 KILLVDDHELIINGIK-NMlaPYPRYKIVGQVdNGLEVYNACRQLEPDIVILDLGLPGMNGLDVIPQLHQRwPAMNILVL 83

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 892137798  79 SAKDSEFDKVIGLELGADDYVTKPFSNRELQARVK 113
Cdd:PRK15369  84 TARQEEHMASRTLAAGALGYVLKKSPQQILLAAIQ 118
PRK10651 PRK10651
transcriptional regulator NarL; Provisional
 4-101 3.02e-11

transcriptional regulator NarL; Provisional


Pssm-ID: 182619 [Multi-domain]  Cd Length: 216  Bit Score: 60.81  E-value: 3.02e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798   4 ILIVDDEkPI--SDIIKFNMTKEGYEVVT-AFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRKTS-SVPILMLS 79
Cdd:PRK10651   9 ILLIDDH-PMlrTGVKQLISMAPDITVVGeASNGEQGIELAESLDPDLILLDLNMPGMNGLETLDKLREKSlSGRIVVFS 87

                         90       100
                 ....*....|....*....|..
gi 892137798  80 AKDSEFDKVIGLELGADDYVTK 101
Cdd:PRK10651  88 VSNHEEDVVTALKRGADGYLLK 109
glnG PRK10923
nitrogen regulation protein NR(I); Provisional
 3-148 4.73e-11

nitrogen regulation protein NR(I); Provisional


Pssm-ID: 182842 [Multi-domain]  Cd Length: 469  Bit Score: 61.81  E-value: 4.73e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798   3 KILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRKTS-SVPILMLSAK 81
Cdd:PRK10923   5 IVWVVDDDSSIRWVLERALAGAGLTCTTFENGNEVLEALASKTPDVLLSDIRMPGMDGLALLKQIKQRHpMLPVIIMTAH 84

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 892137798  82 dSEFD-KVIGLELGADDYVTKPFSNRELQARVKALLRRSQPMPVDGQEADSKPQPIQIGDLEIVPDAY 148
Cdd:PRK10923  85 -SDLDaAVSAYQQGAFDYLPKPFDIDEAVALVERAISHYQEQQQPRNIQVNGPTTDIIGEAPAMQDVF 151
REC_TPR cd17589
phosphoacceptor receiver (REC) domain of uncharacterized tetratricopeptide repeat (TPR) ...
 4-112 9.54e-11

phosphoacceptor receiver (REC) domain of uncharacterized tetratricopeptide repeat (TPR)-containing response regulators; Response regulators share the common phosphoacceptor REC domain and different output domains. This subfamily contains uncharacterized response regulators with TPR repeats as the effector or output domain, which might contain between 3 to 16 TPR repeats (each about 34 amino acids). TPR-containing proteins occur in all domains of life and the abundance of TPR-containing proteins in a bacterial proteome is not indicative of virulence. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays. Some members in this subfamily may contain inactive REC domains lacking canonical metal-binding and active site residues.


Pssm-ID: 381123 [Multi-domain]  Cd Length: 115  Bit Score: 57.27  E-value: 9.54e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798   4 ILIVDDEKPISDIIKFNMTKEGY-EVVTAFNGREALEQFEAEQPDIIILDLMLPE-IDG------LEVAKTIrKTSSVPI 75
Cdd:cd17589    1 FLIVDDQPTFRSMLKSMLRSLGVtRIDTASSGEEALRMCENKTYDIVLCDYNLGKgKNGqqlleeLRHKKLI-SPSTVFI 79

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 892137798  76 lMLSAkDSEFDKVIG-LELGADDYVTKPFSNRELQARV 112
Cdd:cd17589   80 -MVTG-ESSRAMVLSaLELEPDDYLLKPFTVSELRERL 115
psREC_PRR cd17582
pseudo receiver domain of pseudo-response regulators; In Arabidopsis, five pseudo-response ...
 4-102 1.87e-10

pseudo receiver domain of pseudo-response regulators; In Arabidopsis, five pseudo-response regulators (PRRs), also called APRRs, comprise a core group of clock components that controls the pace of the central oscillator of the circadian clock, an endogenous time-keeping mechanism that enables organisms to adapt to external daily cycles. The coordinated sequential expression of PRR9 (APRR9), PRR7 (APRR7), PRR5 (APRR5), PRR3 (APRR3), and PRR1 (APRR1) results in circadian waves that may be at the basis of the endogenous circadian clock. PRRs contain an N-terminal pseudo receiver (psREC) domain that resembles the receiver domain of a two-component response regulator, but lacks an aspartate residue that accepts a phosphoryl group from the sensor kinase, and a CCT motif at the C-terminus that contains a putative nuclear localization signal. The psREC domain is involved in protein-protein interactions.


Pssm-ID: 381120 [Multi-domain]  Cd Length: 104  Bit Score: 56.25  E-value: 1.87e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798   4 ILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAEQP--DIIILDLMLPEIDGLEVAKTIRKTSS---VPILML 78
Cdd:cd17582    1 VLLVENDDSTRQIVTALLRKCSYEVTAASDGLQAWDVLEDEQNeiDLILTEVDLPVSSGFKLLSYIMRHKIcknIPVIMM 80

                         90       100
                 ....*....|....*....|....
gi 892137798  79 SAKDSEFDKVIGLELGADDYVTKP 102
Cdd:cd17582   81 SSQDSVGVVFKCLSKGAADYLVKP 104
REC_RcNtrC-like cd19928
phosphoacceptor receiver (REC) domain of Rhodobacter capsulatus nitrogen regulatory protein C ...
 4-102 9.62e-10

phosphoacceptor receiver (REC) domain of Rhodobacter capsulatus nitrogen regulatory protein C (NtrC) and similar NtrC family response regulators; NtrC family proteins are transcriptional regulators that have REC, AAA+ ATPase/sigma-54 interaction, and DNA-binding output domains. This subfamily of NtrC proteins include NtrC, also called nitrogen regulator I (NRI), from Rhodobacter capsulatus, Azospirillum brasilense, and Azorhizobium caulinodans. NtrC is part of the NtrB/NtrC two-component system that controls the expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. The N-terminal REC domain of NtrC proteins regulate the activity of the protein and its phosphorylation controls the AAA+ domain oligomerization, while the central AAA+ domain participates in nucleotide binding, hydrolysis, oligomerization, and sigma54 interaction. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381155 [Multi-domain]  Cd Length: 100  Bit Score: 54.05  E-value: 9.62e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798   4 ILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRKTS-SVPILMLSAKD 82
Cdd:cd19928    1 ILVADDDRAIRTVLTQALGRAGYEVRTTGNAATLWRWVEEGEGDLVITDVVMPDENGLDLIPRIKKARpDLPIIVMSAQN 80

                         90       100
                 ....*....|....*....|
gi 892137798  83 SEFDKVIGLELGADDYVTKP 102
Cdd:cd19928   81 TLMTAVKAAERGAFEYLPKP 100
PRK09959 PRK09959
acid-sensing system histidine kinase EvgS;
4-123 1.75e-09

acid-sensing system histidine kinase EvgS;


Pssm-ID: 182169 [Multi-domain]  Cd Length: 1197  Bit Score: 57.44  E-value: 1.75e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798    4 ILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIR-KTSSVPILMLSAKD 82
Cdd:PRK09959  961 ILIADDHPTNRLLLKRQLNLLGYDVDEATDGVQALHKVSMQHYDLLITDVNMPNMDGFELTRKLReQNSSLPIWGLTANA 1040

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 892137798   83 SEFDKVIGLELGADDYVTKPFSNRELQARVKALLRRSQPMP 123
Cdd:PRK09959 1041 QANEREKGLSCGMNLCLFKPLTLDVLKTHLSQLHQVAHIAP 1081
REC_NarL cd19931
phosphoacceptor receiver (REC) domain of Nitrate/Nitrite response regulator L (NarL); Nitrate ...
 4-101 3.70e-09

phosphoacceptor receiver (REC) domain of Nitrate/Nitrite response regulator L (NarL); Nitrate/nitrite response regulator protein NarL contains an N-terminal REC domain and a C-terminal LuxR family helix-turn-helix (HTH) DNA-binding output domain. Escherichia coli NarL activates the expression of the nitrate reductase (narGHJI) and formate dehydrogenase-N (fdnGHI) operons, and represses the transcription of the fumarate reductase (frdABCD) operon in response to a nitrate/nitrite induction signal. Phosphorylation of the NarL REC domain releases the C-terminal HTH output domain that subsequently binds specific DNA promoter sites to repress or activate gene expression. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381158 [Multi-domain]  Cd Length: 117  Bit Score: 53.12  E-value: 3.70e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798   4 ILIVDD----EKPISDIIKFNMTkegYEVV-TAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRKTS-SVPILM 77
Cdd:cd19931    1 VLLIDDhpllRKGIKQLIELDPD---FTVVgEASSGEEGIELAERLDPDLILLDLNMKGMSGLDTLKALREEGvSARIVI 77

                         90       100
                 ....*....|....*....|....
gi 892137798  78 LSAKDSEFDKVIGLELGADDYVTK 101
Cdd:cd19931   78 LTVSDAEDDVVTALRAGADGYLLK 101
REC_ETR-like cd19933
phosphoacceptor receiver (REC) domain of plant ethylene receptors ETR1, ETR2, and EIN4, and ...
 3-112 3.88e-09

phosphoacceptor receiver (REC) domain of plant ethylene receptors ETR1, ETR2, and EIN4, and similar proteins; Plant ethylene receptors contain N-terminal transmembrane domains that contain an ethylene binding site and also serve in localization of the receptor to the endoplasmic reticulum or the Golgi apparatus and a C-terminal histidine kinase (HK)-like domain. There are five ethylene receptors (ETR1, ERS1, ETR2, ERS2, and EIN4) in Arabidopsis thaliana. ETR1, ETR2, and EIN4 also contain REC domains C-terminal to the HK domain. ETR1 and ERS1 belong to subfamily 1, and have functional HK domains while ETR2, ERS2, and EIN4 belong to subfamily 2, and lack the necessary residues for HK activity and may function as serine/threonine kinases. The plant hormone ethylene plays an important role in plant growth and development. It regulates seed germination, seedling growth, leaf and petal abscission, fruit ripening, organ senescence, and pathogen responses. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381160 [Multi-domain]  Cd Length: 117  Bit Score: 52.79  E-value: 3.88e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798   3 KILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAEQPD--IIILDLMLPEIDGLEVAKTIRKT---SSVP-IL 76
Cdd:cd19933    2 KVLLVDDNAVNRMVTKGLLEKLGCEVTTVSSGEECLNLLASAEHSfqLVLLDLCMPEMDGFEVALRIRKLfgrRERPlIV 81

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 892137798  77 MLSAKDSEFDKVIGLELGADDYVTKPFSNRELQARV 112
Cdd:cd19933   82 ALTANTDDSTREKCLSLGMNGVITKPVSLHALGDEL 117
REC_WspR-like cd17575
phosphoacceptor receiver (REC) domain of WspR response regulator and similar proteins; The ...
 4-113 4.42e-09

phosphoacceptor receiver (REC) domain of WspR response regulator and similar proteins; The GGDEF response regulator WspR is part of the Wsp system that is homologous to chemotaxis systems and also includes the membrane-bound receptor protein WspA. In response to growth on surfaces, WspR is phosphorylated by the Wsp signal transduction complex and is activated, functioning as a diguanylate cyclase (DGC) that catalyzes c-di-GMP synthesis. WspR is a hybrid response regulator-diguanylate cyclase, containing an N-terminal REC domain and a C-terminal GGDEF domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381117 [Multi-domain]  Cd Length: 128  Bit Score: 53.18  E-value: 4.42e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798   4 ILIVDDEKPISDIIKFNMTKEGyEVVTAF--NGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIR---KTSSVPILML 78
Cdd:cd17575    3 VLLVDDQAIIGEAVRRALADEE-DIDFHYcsDPTEAIEVASQIKPTVILQDLVMPGVDGLTLVRFFRanpATRDIPIIVL 81

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 892137798  79 SAKDSEFDKVIGLELGADDYVTKPFSNRELQARVK 113
Cdd:cd17575   82 STKEEPEVKSEAFALGANDYLVKLPDKIELVARIR 116
REC_GlnL-like cd17565
phosphoacceptor receiver (REC) domain of transcriptional regulatory protein GlnL and similar ...
 4-102 4.86e-09

phosphoacceptor receiver (REC) domain of transcriptional regulatory protein GlnL and similar proteins; Bacillus subtilis GlnL is part of the GlnK-GlnL (formerly YcbA-YcbB) two-component system that positively regulates the expression of the glsA-glnT (formerly ybgJ-ybgH) operon in response to glutamine. It contains a REC domain and a DNA-binding output domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381112 [Multi-domain]  Cd Length: 103  Bit Score: 52.28  E-value: 4.86e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798   4 ILIVDDEKPISDIIKFNMTKE--GYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRKTSSVP-ILMLSA 80
Cdd:cd17565    1 FYIVDDDKNIIKILSDIIEDDdlGEVVGEADNGAQAYDEILFLQPDIVLIDLLMPGMDGIQLVRKLKDTGSNGkFIMISQ 80

                         90       100
                 ....*....|....*....|..
gi 892137798  81 KDSEFDKVIGLELGADDYVTKP 102
Cdd:cd17565   81 VSDKEMIGKAYQAGIEFFINKP 102
PRK09958 PRK09958
acid-sensing system DNA-binding response regulator EvgA;
5-101 1.50e-08

acid-sensing system DNA-binding response regulator EvgA;


Pssm-ID: 182168 [Multi-domain]  Cd Length: 204  Bit Score: 52.98  E-value: 1.50e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798   5 LIVDDEkPISDI-IKFNMTKEGYEVVTAF-NGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRKTS-SVPILMLSAK 81
Cdd:PRK09958   4 IIIDDH-PLAIAaIRNLLIKNDIEILAELtEGGSAVQRVETLKPDIVIIDVDIPGVNGIQVLETLRKRQySGIIIIVSAK 82

                         90       100
                 ....*....|....*....|
gi 892137798  82 DSEFDKVIGLELGADDYVTK 101
Cdd:PRK09958  83 NDHFYGKHCADAGANGFVSK 102
PRK13557 PRK13557
histidine kinase; Provisional
 4-116 2.87e-08

histidine kinase; Provisional


Pssm-ID: 237425 [Multi-domain]  Cd Length: 540  Bit Score: 53.52  E-value: 2.87e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798   4 ILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAE-QPDIIILDLMLP-EIDGLEVAKTIRKT-SSVPILMLS- 79
Cdd:PRK13557 418 ILIVDDRPDVAELARMILEDFGYRTLVASNGREALEILDSHpEVDLLFTDLIMPgGMNGVMLAREARRRqPKIKVLLTTg 497

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 892137798  80 -AKDS-EFDKVIGLELgadDYVTKPFSNRELQARVKALL 116
Cdd:PRK13557 498 yAEASiERTDAGGSEF---DILNKPYRRAELARRVRMVL 533
fixJ PRK09390
response regulator FixJ; Provisional
 6-182 5.02e-08

response regulator FixJ; Provisional


Pssm-ID: 181815 [Multi-domain]  Cd Length: 202  Bit Score: 51.54  E-value: 5.02e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798   6 IVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRKT-SSVPILMLSAKDSE 84
Cdd:PRK09390   8 VVDDDEAMRDSLAFLLDSAGFEVRLFESAQAFLDALPGLRFGCVVTDVRMPGIDGIELLRRLKARgSPLPVIVMTGHGDV 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798  85 FDKVIGLELGADDYVTKPFSNRELQARVKALLRRSQPMPVDGQEADSKPQPIQigdleivpdayvakkygeelDLTHREF 164
Cdd:PRK09390  88 PLAVEAMKLGAVDFIEKPFEDERLIGAIERALAQAPEAAKSEAVAADIRARIA--------------------SLSERER 147

                        170
                 ....*....|....*....
gi 892137798 165 ELLYHL-ASHTGQVITREH 182
Cdd:PRK09390 148 QVMDGLvAGLSNKVIARDL 166
PRK11107 PRK11107
hybrid sensory histidine kinase BarA; Provisional
 27-102 7.16e-08

hybrid sensory histidine kinase BarA; Provisional


Pssm-ID: 236848 [Multi-domain]  Cd Length: 919  Bit Score: 52.54  E-value: 7.16e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798  27 EVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRKTS---SVPILMLSAK--DSEFDKVigLELGADDYVTK 101
Cdd:PRK11107 693 HVVLCDSGHQAVEQAKQRPFDLILMDIQMPGMDGIRACELIRQLPhnqNTPIIAVTAHamAGERERL--LSAGMDDYLAK 770


                 .
gi 892137798 102 P 102
Cdd:PRK11107 771 P 771
REC_RocR cd17530
phosphoacceptor receiver (REC) domain of response regulator RocR; The response regulator RocR ...
 3-110 9.94e-08

phosphoacceptor receiver (REC) domain of response regulator RocR; The response regulator RocR from some pathogens contains an N-terminal phosphoreceiver (REC) domain and a C-terminal EAL domain that possesses c-di-GMP specific phosphodiesterase activity. The RocR REC domain is phosphorylated and modulates its EAL domain enzymatic activity, regulating the local level of c-di-GMP. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381086 [Multi-domain]  Cd Length: 123  Bit Score: 49.36  E-value: 9.94e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798   3 KILIVDDEKPISDIIKFNMTKEGYEVVTAF-NGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRKTSSVPILMLSak 81
Cdd:cd17530    2 RVLVLDDDPFQCMMAATILEDLGPGNVDEAdDGREALVILLCNAPDIIICDLKMPDMDGIEFLRHLAESHSNAAVILM-- 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 892137798  82 dSEFDKVI-----------GLELGADdyVTKPFSNRELQA 110
Cdd:cd17530   80 -SGLDGGIlesaetlaganGLNLLGT--LSKPFSPEELTE 116
PRK14084 PRK14084
DNA-binding response regulator;
3-144 1.10e-07

DNA-binding response regulator;


Pssm-ID: 184495 [Multi-domain]  Cd Length: 246  Bit Score: 50.91  E-value: 1.10e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798   3 KILIVDDEKPISDIIKFNMTK-EGYEVVT-AFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRKTSSVPILMLSA 80
Cdd:PRK14084   2 KALIVDDEPLARNELTYLLNEiGGFEEINeAENVKETLEALLINQYDIIFLDINLMDESGIELAAKIQKMKEPPAIIFAT 81

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 892137798  81 KDSEFdKVIGLELGADDYVTKPFSnrelQARVKALLRRSQPMPVDGQEADSKPQPIQIGDLEIV 144
Cdd:PRK14084  82 AHDQF-AVKAFELNATDYILKPFE----QKRIEQAVNKVRATKAKDDNNASAIANDMSANFDQS 140
REC_DesR-like cd19930
phosphoacceptor receiver (REC) domain of DesR and similar proteins; This group is composed of ...
 28-108 1.22e-07

phosphoacceptor receiver (REC) domain of DesR and similar proteins; This group is composed of Bacillus subtilis DesR, Streptococcus pneumoniae response regulator spr1814, and similar proteins, all containing an N-terminal REC domain and a C-terminal LuxR family helix-turn-helix (HTH) DNA-binding output domain. DesR is a response regulator that, together with its cognate sensor kinase DesK, comprises a two-component regulatory system that controls membrane fluidity. Phosphorylation of the REC domain of DesR is allosterically coupled to two distinct exposed surfaces of the protein, controlling noncanonical dimerization/tetramerization, cooperative activation, and DesK binding. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381157 [Multi-domain]  Cd Length: 117  Bit Score: 48.81  E-value: 1.22e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798  28 VVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRK---TSSVPILMLSAKDSEFDKviGLELGADDYVTKPFS 104
Cdd:cd19930   27 VAQASNGQEALRLVLKHSPDVAILDIEMPGRTGLEVAAELREelpDTKVLIVTTFGRPGYFRR--ALAAGVDGYVLKDRP 104


                 ....
gi 892137798 105 NREL 108
Cdd:cd19930  105 IEEL 108
REC_PhyR cd17540
phosphoacceptor receiver (REC) domain of response regulator PhyR and similar proteins; PhyR is ...
 3-112 4.46e-07

phosphoacceptor receiver (REC) domain of response regulator PhyR and similar proteins; PhyR is a hybrid stress regulator that contains an N-terminal sigma-like (SL) domain and a C-terminal REC domain. Phosphorylation of the REC domain is known to promote binding of the SL domain to an anti-sigma factor. PhyR thus functions as an anti-anti-sigma factor in its phosphorylated state. It is involved in the general stress response. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381095 [Multi-domain]  Cd Length: 117  Bit Score: 47.24  E-value: 4.46e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798   3 KILIVDDEKPISDIIKFNMTKEGYEVV-TAFNGREALEQFEAEQPDIIILDLMLPE-IDGLEVAKTIRKTSSVPILMLSA 80
Cdd:cd17540    2 RVLIIEDEPLIAMDLEQIVEDLGHQVVgIARTRDEAVALARRERPDLILADIQLADgSSGIDAVNEILTTHDVPVIFVTA 81

                         90       100       110
                 ....*....|....*....|....*....|..
gi 892137798  81 KDSEFdkVIGLELGADDYVTKPFSNRELQARV 112
Cdd:cd17540   82 YPERL--LTGERPEPTFLITKPFDPEMVKAAI 111
REC_hyHK_blue-like cd18161
phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinase/response regulators ...
 4-103 1.99e-06

phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinase/response regulators similar to Pseudomonas savastanoi blue-light-activated histidine kinase; Typically, two-component regulatory systems (TCSs) consist of a sensor (histidine kinase) that responds to specific input(s) by modifying the output of a cognate response regulator (RR). TCSs allow organisms to sense and respond to changes in environmental conditions. Hybrid sensor histidine kinase (HK)/response regulators contain all the elements of a classical TCS in a single polypeptide chain. Pseudomonas savastanoi blue-light-activated histidine kinase is a photosensitive HK and RR that is involved in increased bacterial virulence upon exposure to light. RRs share the common phosphoacceptor REC domain and different effector/output domains such as DNA, RNA, ligand-binding, protein-binding, or enzymatic domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381145 [Multi-domain]  Cd Length: 102  Bit Score: 45.03  E-value: 1.99e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798   4 ILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAE-QPDIIILDLMLP-EIDGLEVAKTIRKT-SSVPILMLSA 80
Cdd:cd18161    1 VLVVEDDPDVRRLTAEVLEDLGYTVLEAASGDEALDLLESGpDIDLLVTDVIMPgGMNGSQLAEEARRRrPDLKVLLTSG 80

                         90       100
                 ....*....|....*....|...
gi 892137798  81 KDSEFDKVIGLELGAdDYVTKPF 103
Cdd:cd18161   81 YAENAIEGGDLAPGV-DVLSKPF 102
REC_HupR cd17596
phosphoacceptor receiver (REC) domain of hydrogen uptake protein regulator (HupR); Members of ...
 4-117 2.55e-06

phosphoacceptor receiver (REC) domain of hydrogen uptake protein regulator (HupR); Members of this subfamily are response regulator components of two-component systems that regulates hydrogenase activity, including HupR and HoxA. HupR is part of the HupT/HupR system that controls the synthesis of the membrane-bound [NiFe]hydrogenase, HupSL, of the photosynthetic bacterium Rhodobacter capsulatus. It belongs to the nitrogen regulatory protein C (NtrC) family of response regulators, which activate transcription by RNA polymerase (RNAP) in response to a change in the environment. HupR is an unusual member of this family as it activates transcription when unphosphorylated, and transcription is inhibited by phosphorylation. Proteins in this subfamily contain an N-terminal REC domain, a central sigma-54 interaction domain that lacks ATPase activity, and a C-terminal DNA-binding domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381127 [Multi-domain]  Cd Length: 133  Bit Score: 45.44  E-value: 2.55e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798   4 ILIVDDEKPISDIIKFNMtKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRKT--SSVPILMLSAK 81
Cdd:cd17596    3 ILVVDDEVRSLEALRRTL-EEDFDVLTAASAEEALAILEEEWVQVILCDQRMPGTTGVEFLKEVRERwpEVVRIIISGYT 81

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 892137798  82 DSEfDKVIGL-ELGADDYVTKPFSNRELQARVKALLR 117
Cdd:cd17596   82 DSE-DIIAGInEAGIYQYLTKPWHPDQLLLTVRNAAR 117
PEP_resp_reg TIGR02915
PEP-CTERM-box response regulator transcription factor; Members of this protein family share ...
 4-117 2.94e-06

PEP-CTERM-box response regulator transcription factor; Members of this protein family share full-length homology with (but do not include) the acetoacetate metabolism regulatory protein AtoC (see SP|Q06065). These proteins have a Fis family DNA binding sequence (pfam02954), a response regulator receiver domain (pfam00072), and sigma-54 interaction domain (pfam00158). [Regulatory functions, DNA interactions]


Pssm-ID: 274348 [Multi-domain]  Cd Length: 445  Bit Score: 47.44  E-value: 2.94e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798    4 ILIVDDEKPISDIIKFNMtkEGYEVVTAFNGREALEQFEAEQPDIIILDLMLP-----EIDGLEVAKTIRKTS-SVPILM 77
Cdd:TIGR02915   1 LLIVEDDLGLQKQLKWSF--ADYELAVAADRESAIALVRRHEPAVVTLDLGLPpdadgASEGLAALQQILAIApDTKVIV 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 892137798   78 LSAKDSEFDKVIGLELGADDYVTKPFSNRELQARVKALLR 117
Cdd:TIGR02915  79 ITGNDDRENAVKAIGLGAYDFYQKPIDPDVLKLIVDRAFH 118
PRK11697 PRK11697
two-component system response regulator BtsR;
1-129 4.68e-06

two-component system response regulator BtsR;


Pssm-ID: 236956 [Multi-domain]  Cd Length: 238  Bit Score: 45.99  E-value: 4.68e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798   1 MKKILIVDDEKPISDIIKFNMTKEG-YEVV-TAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRKTSSVPILML 78
Cdd:PRK11697   1 MIKVLIVDDEPLAREELRELLQEEGdIEIVgECSNAIEAIGAIHRLKPDVVFLDIQMPRISGLELVGMLDPEHMPYIVFV 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 892137798  79 SAKDsEFdKVIGLELGADDYVTKPFSNRELQARVKALLRRSQPMPVDGQEA 129
Cdd:PRK11697  81 TAFD-EY-AIKAFEEHAFDYLLKPIDPARLAKTLARLRQERSPQDVLLPEA 129
REC_RitR-like cd19922
receiver (REC) domain of orphan response regulator RitR and similar domains; Streptococcus ...
 4-112 9.83e-06

receiver (REC) domain of orphan response regulator RitR and similar domains; Streptococcus pneumoniae RitR (Repressor of iron transport Regulator, formerly RR489) is an orphan two-component signal transduction response regulator that is required for lung pathogenicity. It acts to repress iron uptake via binding the pneumococcal iron uptake (Piu) transporter promoter. Members of this subfamily contain REC and DNA-binding output domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays. However, members of this family do not contain the phosphorylatable aspartic acid residue and are phosphorylation-independent.


Pssm-ID: 381149 [Multi-domain]  Cd Length: 110  Bit Score: 43.24  E-value: 9.83e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798   4 ILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRKT--SSVPILMLSAK 81
Cdd:cd19922    1 ILLLEKERNLAHFLSLELQKEGYRVDLVETGQEALSLALETDYDLILLNVNLSDMSAQDFAEKLSRIkpASVIIVLDHWE 80

                         90       100       110
                 ....*....|....*....|....*....|..
gi 892137798  82 D-SEFDKVIglELGADDYVTKPFSNRELQARV 112
Cdd:cd19922   81 DlQEELEEV--QRFAVSYVVKPVLISNLVDKI 110
PRK10360 PRK10360
transcriptional regulator UhpA;
1-171 2.09e-05

transcriptional regulator UhpA;


Pssm-ID: 182408 [Multi-domain]  Cd Length: 196  Bit Score: 43.81  E-value: 2.09e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798   1 MKKILIVDDEKPI-SDIIKFNMTKEGYEVVTAF-NGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRKTSSVpiLML 78
Cdd:PRK10360   1 MITVALIDDHLIVrSGFAQLLGLEPDLQVVAEFgSGREALAGLPGRGVQVCICDISMPDISGLELLSQLPKGMAT--IML 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798  79 SAKDSEFDKVIGLELGADDYVTKPFSNRELQARVKAllrrsqpmpvdgqeadskpqpIQIGDLEIVPDAYVAKKYGEELD 158
Cdd:PRK10360  79 SVHDSPALVEQALNAGARGFLSKRCSPDELIAAVHT---------------------VATGGCYLTPDIAIKLASGRQDP 137

                        170
                 ....*....|...
gi 892137798 159 LTHREFELLYHLA 171
Cdd:PRK10360 138 LTKRERQVAEKLA 150
PRK10403 PRK10403
nitrate/nitrite response regulator protein NarP;
3-101 2.47e-05

nitrate/nitrite response regulator protein NarP;


Pssm-ID: 182431 [Multi-domain]  Cd Length: 215  Bit Score: 43.69  E-value: 2.47e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798   3 KILIVDDEkPI--SDIIKFNMTKEGYEVVT-AFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRKTS-SVPILML 78
Cdd:PRK10403   8 QVLIVDDH-PLmrRGVRQLLELDPGFEVVAeAGDGASAIDLANRLDPDVILLDLNMKGMSGLDTLNALRRDGvTAQIIIL 86

                         90       100
                 ....*....|....*....|...
gi 892137798  79 SAKDSEFDKVIGLELGADDYVTK 101
Cdd:PRK10403  87 TVSDASSDVFALIDAGADGYLLK 109
REC_LytTR_AgrA-like cd17533
phosphoacceptor receiver (REC) domain of LytTR/AlgR family response regulators similar to AgrA; ...
 3-116 2.55e-05

phosphoacceptor receiver (REC) domain of LytTR/AlgR family response regulators similar to AgrA; Members of the LytTR/AlgR family of response regulators contain a REC domain and a unique LytTR DNA-binding output domain that lacks the helix-turn-helix motif and consists mostly of beta-strands. Transcriptional regulators with the LytTR-type output domains are involved in biosynthesis of extracellular polysaccharides, fimbriation, expression of exoproteins, including toxins, and quorum sensing. Included in this AgrA-like group of LytTR/AlgR family response regulators are Staphylococcus aureus accessory gene regulator protein A (AgrA) and Streptococcus pneumoniae response regulator ComE, which are members of two-component regulatory systems. AgrA is a global regulator that controls the synthesis of virulence factors and other exoproteins. ComE is part of the ComD-ComE system that is part of a quorum-sensing signaling pathway that controls the development of competence, a physiological state required for genetic transformation. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381088 [Multi-domain]  Cd Length: 131  Bit Score: 42.61  E-value: 2.55e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798   3 KILIVDDEKP----ISDIIKFNMTKEGYEVV--TAFNGREALEQ---FEAEQPDIIILDLMLPEIDGLEVAKTIRKTS-S 72
Cdd:cd17533    2 NIFILEDDKIqrvrLEEIIENILKIENIEYVieLTGKTEELLEKikeRGKNGIYFLDIDIKMEEKNGLEVAQKIRKYDpY 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 892137798  73 VPILMLSAKdSEFDKViGLE--LGADDYVTKPFSNRELQARVKALL 116
Cdd:cd17533   82 AIIIFVTTH-SEFAPL-TFEykVAALDFILKPLKLEEFKKRIEECI 125
REC_1_GGDEF cd19921
first phosphoacceptor receiver (REC) domain of uncharacterized GGDEF domain proteins; This ...
 3-118 3.74e-05

first phosphoacceptor receiver (REC) domain of uncharacterized GGDEF domain proteins; This family is composed of uncharacterized PleD-like response regulators that contain two N-terminal REC domains and a C-terminal diguanylate cyclase output domain with the characteristic GGDEF motif at the active site. Unlike PleD which contains a REC-like adaptor domain, the second REC domain of these uncharacterized GGDEF domain proteins contains characteristic metal-binding and active site residues. PleD response regulators are global regulators of cell metabolism in some important human pathogens. This model describes the first REC domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381148 [Multi-domain]  Cd Length: 115  Bit Score: 41.78  E-value: 3.74e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798   3 KILIVDDEKPISDIIKFNMTKE-GYEVVTAFNGREALEQFEAEQPDII-ILDLMLPEI-DGlEVAKTIRKtSSVPILMLS 79
Cdd:cd19921    1 KVLIVEDSKTFSKVLKHLIAQElGLEVDVAETLAEAKALLEEGDDYFAaLVDLNLPDApNG-EAVDLVLE-KGIPVIVLT 78

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 892137798  80 AKDSEFDKVIGLELGADDYVTKpfSNRELQARVKALLRR 118
Cdd:cd19921   79 GSFDEDKRETLLSKGVVDYVLK--DSRYSYDYVVKLVRR 115
PRK10841 PRK10841
two-component system sensor histidine kinase RcsC;
3-104 5.48e-05

two-component system sensor histidine kinase RcsC;


Pssm-ID: 182772 [Multi-domain]  Cd Length: 924  Bit Score: 43.81  E-value: 5.48e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798   3 KILIVDDEkPI-----SDiikfNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRKTS-SVPIL 76
Cdd:PRK10841 803 MILVVDDH-PInrrllAD----QLGSLGYQCKTANDGVDALNVLSKNHIDIVLTDVNMPNMDGYRLTQRLRQLGlTLPVI 877

                         90       100
                 ....*....|....*....|....*...
gi 892137798  77 MLSAKDSEFDKVIGLELGADDYVTKPFS 104
Cdd:PRK10841 878 GVTANALAEEKQRCLEAGMDSCLSKPVT 905
PRK09935 PRK09935
fimbriae biosynthesis transcriptional regulator FimZ;
5-116 9.79e-05

fimbriae biosynthesis transcriptional regulator FimZ;


Pssm-ID: 182154 [Multi-domain]  Cd Length: 210  Bit Score: 42.17  E-value: 9.79e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798   5 LIVDDEKPI---SDIIKFNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRK-TSSVPILMLSA 80
Cdd:PRK09935   6 VIIMDTHPIirmSIEVLLQKNSELQIVLKTDDYRITIDYLRTRPVDLIIMDIDLPGTDGFTFLKRIKQiQSTVKVLFLSS 85

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 892137798  81 KDSEFDKVIGLELGADDYVTKPFSNRELQARVKALL 116
Cdd:PRK09935  86 KSECFYAGRAIQAGANGFVSKCNDQNDIFHAVQMIL 121
PRK09483 PRK09483
response regulator; Provisional
 1-101 1.48e-04

response regulator; Provisional


Pssm-ID: 236538 [Multi-domain]  Cd Length: 217  Bit Score: 41.63  E-value: 1.48e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798   1 MKKILIVDDEKPISDIIKFNMTKE-GYEVV-TAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTI-RKTSSVPILM 77
Cdd:PRK09483   1 MINVLLVDDHELVRAGIRRILEDIkGIKVVgEACCGEDAVKWCRTNAVDVVLMDMNMPGIGGLEATRKIlRYTPDVKIIM 80

                         90       100
                 ....*....|....*....|....*.
gi 892137798  78 LSA--KDSEFDKVigLELGADDYVTK 101
Cdd:PRK09483  81 LTVhtENPLPAKV--MQAGAAGYLSK 104
PLN03029 PLN03029
type-a response regulator protein; Provisional
 4-142 2.84e-04

type-a response regulator protein; Provisional


Pssm-ID: 215544 [Multi-domain]  Cd Length: 222  Bit Score: 40.79  E-value: 2.84e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798   4 ILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALE-----QFEAEQPDI---------------IILDLMLPEIDGLEV 63
Cdd:PLN03029  11 VLAVDDSLIDRKLIEKLLKTSSYQVTTVDSGSKALKflglhEDDRSNPDTpsvspnshqevevnlIITDYCMPGMTGYDL 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798  64 AKTIRKTSS---VPILMLSAKDSEFDKVIGLELGADDYVTKPFSNRELQaRVKALLRRSQpMPVDGQEADSKPQPIQIGD 140
Cdd:PLN03029  91 LKKIKESSSlrnIPVVIMSSENVPSRITRCLEEGAEEFFLKPVQLSDLN-RLKPHMMKTK-SKNQKQENQEKQEKLEESE 168


                 ..
gi 892137798 141 LE 142
Cdd:PLN03029 169 IQ 170
PRK10153 PRK10153
DNA-binding transcriptional activator CadC; Provisional
 137-225 3.52e-04

DNA-binding transcriptional activator CadC; Provisional


Pssm-ID: 236658 [Multi-domain]  Cd Length: 517  Bit Score: 41.18  E-value: 3.52e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798 137 QIGDLEIVPDAYVAKKYGEELDLTHREFELLYHLASHTGQVITREHLLETVWGydyfGDVRT---VDVTVRRLREKIED- 212
Cdd:PRK10153   7 RIGEWLVTPSENKISRQGREVTLEPRLIDLLVFFAQHSGEVLSRDELIDHVWD----RAIVTdhvVTQSISELRKSLKDg 82

                         90
                 ....*....|....*
gi 892137798 213 TPSRPEYILT--RRG 225
Cdd:PRK10153  83 REDNPEYIVTvpKRG 97
REC_typeA_ARR cd17581
phosphoacceptor receiver (REC) domain of type A Arabidopsis response regulators (ARRs) and ...
 4-102 5.28e-04

phosphoacceptor receiver (REC) domain of type A Arabidopsis response regulators (ARRs) and similar proteins; Type-A response regulators of Arabidopsis (ARRs) are involved in cytokinin signaling, which involves a phosphorelay cascade by histidine kinase receptors (AHKs), histidine phosphotransfer proteins (AHPs) and downstream ARRs. Cytokinin is a plant hormone implicated in many growth and development processes including shoot organogenesis, leaf senescence, sink/source relationships, vascular development, lateral bud release, and photomorphogenic development. Type-A ARRs function downstream of and are regulated by type-B ARRs, which are a class of MYB-type transcription factors. As primary cytokinin response genes, type-A ARRs act as redundant negative feedback regulators of cytokinin signaling by inactivating the phosphorelay. ARRs are divided into two groups, type-A and -B, according to their sequence and domain structure. Type-A ARRs are similar in domain structure to CheY, in that they lack a typical output domain and only contain a stand-alone receiver (REC) domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381119 [Multi-domain]  Cd Length: 122  Bit Score: 38.89  E-value: 5.28e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798   4 ILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALE-----------QFEAEQPDIIILDLMLPEIDGLEVAKTIRKTSS 72
Cdd:cd17581    1 VLAVDDSLVDRKVIERLLRISSCRVTAVDSGKRALEflgledeedssNFNEPKVNMIITDYCMPGMTGYDLLKKVKESSA 80

                         90       100       110
                 ....*....|....*....|....*....|...
gi 892137798  73 ---VPILMLSAKDSEFDKVIGLELGADDYVTKP 102
Cdd:cd17581   81 lkeIPVVIMSSENIPTRISRCLEEGAEDFLLKP 113
PRK09191 PRK09191
two-component response regulator; Provisional
 3-80 8.61e-04

two-component response regulator; Provisional


Pssm-ID: 236402 [Multi-domain]  Cd Length: 261  Bit Score: 39.45  E-value: 8.61e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798   3 KILIVDDEKPISDIIKfNMTKE-GYEVV-TAFNGREALEQFEAEQPDIIILDLML-PEIDGLEVAKTIRKTSSVPILMLS 79
Cdd:PRK09191 139 RVLIIEDEPIIAMDLE-QLVESlGHRVTgIARTRAEAVALAKKTRPGLILADIQLaDGSSGIDAVNDILKTFDVPVIFIT 217


                 .
gi 892137798  80 A 80
Cdd:PRK09191 218 A 218
PRK10430 PRK10430
two-component system response regulator DcuR;
1-127 1.02e-03

two-component system response regulator DcuR;


Pssm-ID: 182454 [Multi-domain]  Cd Length: 239  Bit Score: 39.32  E-value: 1.02e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798   1 MKKILIVDDEKPISDIIKFNMTK-EGYE----VVTAFNGREALeqFEAEQP-DIIILDLMLPEIDGLEVAKTIRKTS--S 72
Cdd:PRK10430   1 MINVLIVDDDAMVAELNRRYVAQiPGFQccgtASTLEQAKEII--FNSDTPiDLILLDIYMQQENGLDLLPVLHEAGckS 78

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 892137798  73 VPILMLSAKDSEFDKViGLELGADDYVTKPF-------------------SNREL--QARVKALLRRSQPMPVDGQ 127
Cdd:PRK10430  79 DVIVISSAADAATIKD-SLHYGVVDYLIKPFqasrfeealtgwrqkkmalEKHQYydQAELDQLIHGSSSNEQDPR 153
PRK13435 PRK13435
response regulator; Provisional
 1-109 7.20e-03

response regulator; Provisional


Pssm-ID: 184052 [Multi-domain]  Cd Length: 145  Bit Score: 35.80  E-value: 7.20e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137798   1 MKKILIVDDEKPISDIIKFNMTKEGYEVV-TAFNGREALEQFEAEQPDIIILDLMLpeIDGL---EVAKTIRKTSSVPIL 76
Cdd:PRK13435   5 QLKVLIVEDEALIALELEKLVEEAGHEVVgIAMSSEQAIALGRRRQPDVALVDVHL--ADGPtgvEVARRLSADGGVEVV 82

                         90       100       110
                 ....*....|....*....|....*....|....
gi 892137798  77 MLSAKdsefDKVIGLEL-GADDYVTKPFSNRELQ 109
Cdd:PRK13435  83 FMTGN----PERVPHDFaGALGVIAKPYSPRGVA 112
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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