|
Name |
Accession |
Description |
Interval |
E-value |
| HK_VicK |
NF033093 |
cell wall metabolism sensor histidine kinase VicK; This model describes the protein VicK (or ... |
1-439 |
0e+00 |
|
cell wall metabolism sensor histidine kinase VicK; This model describes the protein VicK (or WalK) as found in Streptococcus pneumoniae, This protein is shorter than the WalK of Staphylococcus aureus, although apparently is functionally similar. Compare to model NF033092 (HK_WalK). VicK is a sensor histidine kinase involved in regulating cell wall metabolism. Its two component system partner is the response regulatory VicR.
Pssm-ID: 467965 [Multi-domain] Cd Length: 448 Bit Score: 809.33 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 1 MLDLLKQTIFTRDFIFILILLGFILVVTLLLLENRRDNIQLKQINQKVKDLIAGDYSKVLDMQGGSEITNITNNLNDLSE 80
Cdd:NF033093 1 MIDNIKQNIFSFEFAFLLLLLGFILYFILLALRNRRDNKQLRQLNQKVKDLIAGDYSEVLDMQGDPELTELTNSLNDLSE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 81 VIRLTQENLEQESKRLNSILFYMTDGVLATNRRGQIIMINDTAKKQLGLVKEDVLNRSILELLKIEENYELRDLITQSPE 160
Cdd:NF033093 81 VFRLTHENLEQEKNRLASILSYMTDGVLATNRRGQIIMINDTAQKQLNVKREEALNMNILDLLDIDDEYDLRDLITKTPE 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 161 LLLDSQDINGEYLNLRVRFALIRRESGFISGLVAVLHDTTEQEKEERERRLFVSNVSHELRTPLTSVKSYLEALDEGALC 240
Cdd:NF033093 161 LTLDSRDENGEFLSLRVRFALIRRESGFISGLVAVLHDTTEQEKEERERRLFVSNVSHELRTPLTSVKSYLEALDEGALS 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 241 ETVAPDFIKVSLDETNRMMRMVTDLLHLSRIDNATSHLDVELINFTAFITFILNRFDKMKGQEKE--KKYELVRDYPINS 318
Cdd:NF033093 241 EPVAPSFIKVSLDETNRMMRMISDLLSLSRIDNQTSHLDVELTNFTAFITFILNRFDQIKSQDTEtgKKYEIVRDYPITS 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 319 IWMEIDTDKMTQVVDNILNNAIKYSPDGGKITVRMKTTEDQMILSISDHGLGIPKQDLPRIFDRFYRVDRARSRAQGGTG 398
Cdd:NF033093 321 IWVEIDTDKMTQVIDNILNNAIKYSPDGGKITVSMKTTDTQLIISISDEGLGIPKKDLPLIFDRFYRVDKARSRAQGGTG 400
|
410 420 430 440
....*....|....*....|....*....|....*....|.
gi 892137799 399 LGLSIAKEIIKQHKGFIWAKSEYGKGSTFTIVLPYDKDAVK 439
Cdd:NF033093 401 LGLAIAKEIIKQHKGFIWAKSEYGKGSTFTIVLPYDKDAVK 441
|
|
| HK_WalK |
NF033092 |
cell wall metabolism sensor histidine kinase WalK; This model describes WalK as found in ... |
54-433 |
0e+00 |
|
cell wall metabolism sensor histidine kinase WalK; This model describes WalK as found in Staphylococcus aureus (sp|Q2G2U4.1|WALK_STAA8). A shorter version, as found in Streptococcus pneumoniae, called WalK(Spn) or VicK, is not included. WalK is part of a two-component system and works with partner protein WalR.
Pssm-ID: 467964 [Multi-domain] Cd Length: 594 Bit Score: 527.01 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 54 GDYSKVLDMQGGSEITNITNNLNDLSEVIRLTQENLEQESKRLNSILFYMTDGVLATNRRGQIIMINDTAKKQLGLVKED 133
Cdd:NF033092 218 GDFSRKVKVYGNDEIGQLAEAFNNLTKRLQEAQATTESERRKLDSVLSHMTDGVIATDRRGRVILINDPALEMLNVSRET 297
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 134 VLNRSILELLKIEENYELRDLITQSPELLLDSQDINGEYLnLRVRFALIRRESGFISGLVAVLHDTTEQEKEERERRLFV 213
Cdd:NF033092 298 VLGQSILDVLGLEEEYTLRDLLEEQDSLLLDFSTEEEPLI-LRANFSVIQRESGFINGLIAVLHDVTEQEKIEQERREFV 376
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 214 SNVSHELRTPLTSVKSYLEALDEGALC-ETVAPDFIKVSLDETNRMMRMVTDLLHLSRIDNATSHLDVELINFTAFITFI 292
Cdd:NF033092 377 ANVSHELRTPLTTMRSYLEALADGAWKdPELAPRFLGVTQNETERMIRLVNDLLQLSRMDSKDYKLNKEWVNFNEFFNYI 456
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 293 LNRFDkMkgQEKEKKYELVRDYPINSIWMEIDTDKMTQVVDNILNNAIKYSPDGGKITVRMKTTEDQMILSISDHGLGIP 372
Cdd:NF033092 457 IDRFE-M--ILKNKNITFKREFPKRDLWVEIDTDKITQVLDNIISNAIKYSPEGGTITFRLLETHNRIIISISDQGLGIP 533
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 892137799 373 KQDLPRIFDRFYRVDRARSRAQGGTGLGLSIAKEIIKQHKGFIWAKSEYGKGSTFTIVLPY 433
Cdd:NF033092 534 KKDLDKIFDRFYRVDKARSRKMGGTGLGLAIAKEVVEAHGGRIWAESEEGKGTTIYFTLPY 594
|
|
| WalK |
COG5002 |
Sensor histidine kinase WalK [Signal transduction mechanisms]; |
75-436 |
2.92e-92 |
|
Sensor histidine kinase WalK [Signal transduction mechanisms];
Pssm-ID: 444026 [Multi-domain] Cd Length: 390 Bit Score: 284.52 E-value: 2.92e-92
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 75 LNDLSEVIRLTQENLEQESKRLNSILFYMTDGVLATNRRGQIIMINDTAKKQLGLVKEDVLNRSILELLKIEENYELRDL 154
Cdd:COG5002 36 LLLLLLLLLLLLLLLLLALLLLLLLLLLLLLALLLLLLLLLLLLALALLLLALLLLLLLLLLLLALLILLLLLALLILLA 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 155 ITQSPELLLDSQDINGEYLNLRVRFALIRRESgfisgLVAVLHDTTEQEKEERERRLFVSNVSHELRTPLTSVKSYLEAL 234
Cdd:COG5002 116 ALLLLLSELLLLLLLLGRLSLRLSALLLGLLL-----LAAVERDITELERLEQMRREFVANVSHELRTPLTSIRGYLELL 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 235 DEGAL-CETVAPDFIKVSLDETNRMMRMVTDLLHLSRIDNATSHLDVELINFTAFITFILNRFdkmKGQEKEKKYELVRD 313
Cdd:COG5002 191 LDGAAdDPEERREYLEIILEEAERLSRLVNDLLDLSRLESGELKLEKEPVDLAELLEEVVEEL---RPLAEEKGIELELD 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 314 YPINSIWMEIDTDKMTQVVDNILNNAIKYSPDGGKITVRMKTTEDQMILSISDHGLGIPKQDLPRIFDRFYRVDRARSRA 393
Cdd:COG5002 268 LPEDPLLVLGDPDRLEQVLTNLLDNAIKYTPEGGTITVSLREEDDQVRISVRDTGIGIPEEDLPRIFERFYRVDKSRSRE 347
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 892137799 394 QGGTGLGLSIAKEIIKQHKGFIWAKSEYGKGSTFTIVLPYDKD 436
Cdd:COG5002 348 TGGTGLGLAIVKHIVEAHGGRIWVESEPGKGTTFTITLPLARE 390
|
|
| phoR_proteo |
TIGR02966 |
phosphate regulon sensor kinase PhoR; Members of this protein family are the regulatory ... |
89-431 |
1.30e-73 |
|
phosphate regulon sensor kinase PhoR; Members of this protein family are the regulatory histidine kinase PhoR associated with the phosphate ABC transporter in most Proteobacteria. Related proteins from Gram-positive organisms are not included in this model. The phoR gene usually is adjacent to the response regulator phoB gene (TIGR02154). [Signal transduction, Two-component systems]
Pssm-ID: 274368 [Multi-domain] Cd Length: 333 Bit Score: 234.41 E-value: 1.30e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 89 LEQESKRLNSILFYMTDGVLATNRRGQIIMINDTAKKQLGLVKEDVLNRSILELLKIEENYE-LRDLITQSPelLLDSQD 167
Cdd:TIGR02966 1 LSALLSRFRAAAQALPDAVVVLDEEGQIEWCNPAAERLLGLRWPDDLGQRITNLIRHPEFVEyLAAGRFSEP--LELPSP 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 168 INGE-YLNLRVrFALirresgFISGLVAVLHDTTEQEKEERERRLFVSNVSHELRTPLTSVKSYLEALDEGALCE-TVAP 245
Cdd:TIGR02966 79 INSErVLEIRI-APY------GEEQKLLVARDVTRLRRLEQMRRDFVANVSHELRTPLTVLRGYLETLADGPDEDpEEWN 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 246 DFIKVSLDETNRMMRMVTDLLHLSRIDNATSHLDVELINFTAFITFILNRFdKMKGQEKEKKYELVRDypiNSIWMEIDT 325
Cdd:TIGR02966 152 RALEIMLEQSQRMQSLVEDLLTLSRLESAASPLEDEPVDMPALLDHLRDEA-EALSQGKNHQITFEID---GGVDVLGDE 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 326 DKMTQVVDNILNNAIKYSPDGGKITVRMKTTEDQMILSISDHGLGIPKQDLPRIFDRFYRVDRARSRAQGGTGLGLSIAK 405
Cdd:TIGR02966 228 DELRSAFSNLVSNAIKYTPEGGTITVRWRRDGGGAEFSVTDTGIGIAPEHLPRLTERFYRVDKSRSRDTGGTGLGLAIVK 307
|
330 340
....*....|....*....|....*.
gi 892137799 406 EIIKQHKGFIWAKSEYGKGSTFTIVL 431
Cdd:TIGR02966 308 HVLSRHHARLEIESELGKGSTFSFIF 333
|
|
| KdpD |
COG2205 |
K+-sensing histidine kinase KdpD [Signal transduction mechanisms]; |
212-432 |
3.88e-71 |
|
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 224.79 E-value: 3.88e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 212 FVSNVSHELRTPLTSVKSYLEAL-DEGALCETVAPDFIKVSLDETNRMMRMVTDLLHLSRIDNATSHLDVELINFTAFIT 290
Cdd:COG2205 19 FLANVSHELRTPLTSILGAAELLlDEEDLSPEERRELLEIIRESAERLLRLIEDLLDLSRLESGKLSLELEPVDLAELLE 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 291 FILNRFdkmKGQEKEKKYELVRDYPINSIWMEIDTDKMTQVVDNILNNAIKYSPDGGKITVRMKTTEDQMILSISDHGLG 370
Cdd:COG2205 99 EAVEEL---RPLAEEKGIRLELDLPPELPLVYADPELLEQVLANLLDNAIKYSPPGGTITISARREGDGVRISVSDNGPG 175
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 892137799 371 IPKQDLPRIFDRFYRVDRARSraQGGTGLGLSIAKEIIKQHKGFIWAKSEYGKGSTFTIVLP 432
Cdd:COG2205 176 IPEEELERIFERFYRGDNSRG--EGGTGLGLAIVKRIVEAHGGTIWVESEPGGGTTFTVTLP 235
|
|
| BaeS |
COG0642 |
Signal transduction histidine kinase [Signal transduction mechanisms]; |
100-432 |
2.61e-69 |
|
Signal transduction histidine kinase [Signal transduction mechanisms];
Pssm-ID: 440407 [Multi-domain] Cd Length: 328 Bit Score: 223.25 E-value: 2.61e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 100 LFYMTDGVLATNRRGQIIMINDTAKKQLGLVKEDVLNRSILELLKIEENYELRDLITQSPELLLDSQDINGEYLNLRVRF 179
Cdd:COG0642 1 LLLLLLLLVLLLLLLLLLLLALLLLLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 180 ALIRRESGFISGLVAVLHDTTEQEKEERERRLFVSNVSHELRTPLTSVKSYLEALDEGAlcETVAPDFIKVSLDETNRMM 259
Cdd:COG0642 81 LLLLLLLLLLLLLLLLLALLLLLEEANEAKSRFLANVSHELRTPLTAIRGYLELLLEEL--DEEQREYLETILRSADRLL 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 260 RMVTDLLHLSRIDNATSHLDVELINFTAFITFILNRFdkmKGQEKEKKYELVRDYPINSIWMEIDTDKMTQVVDNILNNA 339
Cdd:COG0642 159 RLINDLLDLSRLEAGKLELEPEPVDLAELLEEVVELF---RPLAEEKGIELELDLPDDLPTVRGDPDRLRQVLLNLLSNA 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 340 IKYSPDGGKITVRMKTTEDQMILSISDHGLGIPKQDLPRIFDRFYRVDraRSRAQGGTGLGLSIAKEIIKQHKGFIWAKS 419
Cdd:COG0642 236 IKYTPEGGTVTVSVRREGDRVRISVEDTGPGIPPEDLERIFEPFFRTD--PSRRGGGTGLGLAIVKRIVELHGGTIEVES 313
|
330
....*....|...
gi 892137799 420 EYGKGSTFTIVLP 432
Cdd:COG0642 314 EPGKGTTFTVTLP 326
|
|
| NtrY |
COG5000 |
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ... |
7-438 |
9.68e-66 |
|
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];
Pssm-ID: 444024 [Multi-domain] Cd Length: 422 Bit Score: 216.75 E-value: 9.68e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 7 QTIFTRDFIFILILLGFILVVTLLLLeNRRDNIQLKQINQKVKDLIAGDYSKVLDMQGGSEITNITNNLNDLSEVIRLTQ 86
Cdd:COG5000 4 QILFLLLLLLIALLLLLLALWLALLL-ARRLTRPLRRLAEATRAVAAGDLSVRLPVTGDDEIGELARAFNRMTDQLKEQR 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 87 ENLEQESKRLNSILFYMTDGVLATNRRGQIIMINDTAKKQLGLVKEDVLNRSILELLKIEENYELRDLITQSPELLLDSQ 166
Cdd:COG5000 83 EELEERRRYLETILENLPAGVIVLDADGRITLANPAAERLLGIPLEELIGKPLEELLPELDLAELLREALERGWQEEIEL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 167 DINGEyLNLRVRFALIRREsgfisGLVAVLHDTTEQEKEERERRL--FVSNVSHELRTPLTSVKSYLEAL-----DEGAL 239
Cdd:COG5000 163 TRDGR-RTLLVRASPLRDD-----GYVIVFDDITELLRAERLAAWgeLARRIAHEIKNPLTPIQLSAERLrrklaDKLEE 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 240 CETVAPDFIKVSLDETNRMMRMVTDLLHLSRIDNAT-SHLDV-ELINFTAFItfilnrfdkMKGQEKEKKYELVRDYPIN 317
Cdd:COG5000 237 DREDLERALDTIIRQVDRLKRIVDEFLDFARLPEPQlEPVDLnELLREVLAL---------YEPALKEKDIRLELDLDPD 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 318 SIWMEIDTDKMTQVVDNILNNAIKYSPDGGKITVRMKTTEDQMILSISDHGLGIPKQDLPRIFDRFYrvdrarSRAQGGT 397
Cdd:COG5000 308 LPEVLADRDQLEQVLINLLKNAIEAIEEGGEIEVSTRREDGRVRIEVSDNGPGIPEEVLERIFEPFF------TTKPKGT 381
|
410 420 430 440
....*....|....*....|....*....|....*....|.
gi 892137799 398 GLGLSIAKEIIKQHKGFIWAKSEYGKGSTFTIVLPYDKDAV 438
Cdd:COG5000 382 GLGLAIVKKIVEEHGGTIELESRPGGGTTFTIRLPLAEEAE 422
|
|
| NtrB |
COG3852 |
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms]; |
89-432 |
3.03e-52 |
|
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
Pssm-ID: 443061 [Multi-domain] Cd Length: 361 Bit Score: 179.66 E-value: 3.03e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 89 LEQESKRLNSILFYMTDGVLATNRRGQIIMINDTAKKQLGLVKEDVLNRSILELLkiEENYELRDLITQS-------PEL 161
Cdd:COG3852 2 LRESEELLRAILDSLPDAVIVLDADGRITYVNPAAERLLGLSAEELLGRPLAELF--PEDSPLRELLERAlaegqpvTER 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 162 LLDSQDINGEYLNLRVRFALIRRESGFIsGLVAVLHDTTEQEKEERERRL---------FVSNVSHELRTPLTSVKSYLE 232
Cdd:COG3852 80 EVTLRRKDGEERPVDVSVSPLRDAEGEG-GVLLVLRDITERKRLERELRRaeklaavgeLAAGLAHEIRNPLTGIRGAAQ 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 233 ----ALDEGALCEtvapdFIKVSLDETNRMMRMVTDLLHLSRidnaTSHLDVELINftafITFILNRFDKMKGQEKEKKY 308
Cdd:COG3852 159 llerELPDDELRE-----YTQLIIEEADRLNNLVDRLLSFSR----PRPPEREPVN----LHEVLERVLELLRAEAPKNI 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 309 ELVRDYPINSIWMEIDTDKMTQVVDNILNNAIKYSPDGGKITVR----------MKTTEDQMILSISDHGLGIPKQDLPR 378
Cdd:COG3852 226 RIVRDYDPSLPEVLGDPDQLIQVLLNLVRNAAEAMPEGGTITIRtrverqvtlgGLRPRLYVRIEVIDNGPGIPEEILDR 305
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 892137799 379 IFDRFYRvdrarSRAqGGTGLGLSIAKEIIKQHKGFIWAKSEYGKGSTFTIVLP 432
Cdd:COG3852 306 IFEPFFT-----TKE-KGTGLGLAIVQKIVEQHGGTIEVESEPGKGTTFRIYLP 353
|
|
| KinE |
COG5809 |
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ... |
87-437 |
1.35e-47 |
|
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444511 [Multi-domain] Cd Length: 489 Bit Score: 170.54 E-value: 1.35e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 87 ENLEQESKRLNSILFYMTDGVLATNRRGQIIMINDTAKKQLGLVKEDVLNRSILELLKIEENYELRDLITQspelLLDSQ 166
Cdd:COG5809 134 EALRESEEKFRLIFNHSPDGIIVTDLDGRIIYANPAACKLLGISIEELIGKSILELIHSDDQENVAAFISQ----LLKDG 209
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 167 DI----------NGEYLNLRVRFALIRRESGfISGLVAVLHDTTEQEKEERERRL---------FVSNVSHELRTPLTSV 227
Cdd:COG5809 210 GIaqgevrfwtkDGRWRLLEASGAPIKKNGE-VDGIVIIFRDITERKKLEELLRKseklsvvgeLAAGIAHEIRNPLTSL 288
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 228 KSYLEALDEGALCETvaPDFIKVSLDETNRMMRMVTDLLHLSRIDNatshLDVELINFTAFI----TFILNRFDkMKGQE 303
Cdd:COG5809 289 KGFIQLLKDTIDEEQ--KTYLDIMLSELDRIESIISEFLVLAKPQA----IKYEPKDLNTLIeeviPLLQPQAL-LKNVQ 361
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 304 KEKKYElvrdYPINSIWMeiDTDKMTQVVDNILNNAIKYSPDGGKITVRMKTTE-DQMILSISDHGLGIPKQDLPRIFDR 382
Cdd:COG5809 362 IELELE----DDIPDILG--DENQLKQVFINLLKNAIEAMPEGGNITIETKAEDdDKVVISVTDEGCGIPEERLKKLGEP 435
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 892137799 383 FYrvdrarSRAQGGTGLGLSIAKEIIKQHKGFIWAKSEYGKGSTFTIVLPYDKDA 437
Cdd:COG5809 436 FY------TTKEKGTGLGLMVSYKIIEEHGGKITVESEVGKGTTFSITLPIKLSE 484
|
|
| phoR |
PRK11006 |
phosphate regulon sensor histidine kinase PhoR; |
105-432 |
3.08e-46 |
|
phosphate regulon sensor histidine kinase PhoR;
Pssm-ID: 182895 [Multi-domain] Cd Length: 430 Bit Score: 165.57 E-value: 3.08e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 105 DGVLATNRRGQIIMINDTAKKQLGLVKEDVLNRSILELLKIEE--NYELRDLITQSPELLLDsqdiNGEYLNLRVrfalI 182
Cdd:PRK11006 109 DAVVLTTEEGNIFWCNGLAQQLLGFRWPEDNGQNILNLLRYPEftQYLKTRDFSRPLTLVLN----NGRHLEIRV----M 180
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 183 RRESGfisGLVAVLHDTTEQEKEERERRLFVSNVSHELRTPLTSVKSYLEALDEGALCETVAPDFIKVSLDETNRMMRMV 262
Cdd:PRK11006 181 PYTEG---QLLMVARDVTQMHQLEGARRNFFANVSHELRTPLTVLQGYLEMMQDQPLEGALREKALHTMREQTQRMEGLV 257
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 263 TDLLHLSRIDNATSHLDVELINFTAFitfilnrfdkMKGQEKE------KKYELVRDypINSIWMEI-DTDKMTQVVDNI 335
Cdd:PRK11006 258 KQLLTLSKIEAAPTIDLNEKVDVPMM----------LRVLEREaqtlsqGKHTITFE--VDNSLKVFgNEDQLRSAISNL 325
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 336 LNNAIKYSPDGGKITVRMKTTEDQMILSISDHGLGIPKQDLPRIFDRFYRVDRARSRAQGGTGLGLSIAKEIIKQHKGFI 415
Cdd:PRK11006 326 VYNAVNHTPEGTHITVRWQRVPQGAEFSVEDNGPGIAPEHIPRLTERFYRVDKARSRQTGGSGLGLAIVKHALSHHDSRL 405
|
330
....*....|....*..
gi 892137799 416 WAKSEYGKGSTFTIVLP 432
Cdd:PRK11006 406 EIESEVGKGTRFSFVLP 422
|
|
| PRK11360 |
PRK11360 |
two-component system sensor histidine kinase AtoS; |
15-435 |
2.38e-45 |
|
two-component system sensor histidine kinase AtoS;
Pssm-ID: 236901 [Multi-domain] Cd Length: 607 Bit Score: 166.30 E-value: 2.38e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 15 IFILILLGFILVVTLLllenRRDNIQLKQINQKVKDLiAGDYSKVL-DMQGgsEITNITNNLNDLSEVIRltqenleqES 93
Cdd:PRK11360 196 LAAGLVIGLLLIFLLS----RRFSANVDIIKDGLSTL-ENDLSTRLpPLPG--ELGEISQAINNLAQALR--------ET 260
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 94 KRLNS-ILFYMTDGVLATNRRGQIIMINDTAKKQLGLVKEDVLNRSILELLKIEE---NYELRDLI--TQSPELLLDSQD 167
Cdd:PRK11360 261 RSLNElILESIADGVIAIDRQGKITTMNPAAEVITGLQRHELVGKPYSELFPPNTpfaSPLLDTLEhgTEHVDLEISFPG 340
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 168 INGEyLNLRVRFALIRRESGFISGLVAVLHDTTEQEKEERERRL---------FVSNVSHELRTPLTSVKSYLEALDEGA 238
Cdd:PRK11360 341 RDRT-IELSVSTSLLHNTHGEMIGALVIFSDLTERKRLQRRVARqerlaalgeLVAGVAHEIRNPLTAIRGYVQIWRQQT 419
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 239 lCETVAPDFIKVSLDETNRMMRMVTDLLHLSRidnaTSHLDVELINFTAFITFILNRFDKMKGQEKeKKYELVRDYPINS 318
Cdd:PRK11360 420 -SDPPSQEYLSVVLREVDRLNKVIDQLLEFSR----PRESQWQPVSLNALVEEVLQLFQTAGVQAR-VDFETELDNELPP 493
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 319 IWmeIDTDKMTQVVDNILNNAIKYSPDGGKITVRMK-TTEDQMILSISDHGLGIPKQDLPRIFDRFYRvdrarSRAQGgT 397
Cdd:PRK11360 494 IW--ADPELLKQVLLNILINAVQAISARGKIRIRTWqYSDGQVAVSIEDNGCGIDPELLKKIFDPFFT-----TKAKG-T 565
|
410 420 430
....*....|....*....|....*....|....*...
gi 892137799 398 GLGLSIAKEIIKQHKGFIWAKSEYGKGSTFTIVLPYDK 435
Cdd:PRK11360 566 GLGLALSQRIINAHGGDIEVESEPGVGTTFTLYLPINP 603
|
|
| COG4251 |
COG4251 |
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ... |
1-432 |
9.37e-42 |
|
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];
Pssm-ID: 443393 [Multi-domain] Cd Length: 503 Bit Score: 154.94 E-value: 9.37e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 1 MLDLLKQTIFTRDFIFILILLGFILVVTLLLLENRRDNIQLKQINQKVKDLIAGDYSKVLDMQGGSEITNITNNLNDLSE 80
Cdd:COG4251 48 IRLLLLLLLSLLALLLLLLLLLLLLLVLAALALLLLLLLLELALVLLALLLVLLLLLALLLLLALLLLLELLLLLLALLL 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 81 VIRLTQENLEQESKRLNSILFYMTDGVLATNRRGQIIMINDTAKKQLGLVKEDVLNRSI---LELLKIEENYELRDLITQ 157
Cdd:COG4251 128 LLLLLALLLLEELALLRLALALLLLLLLLLLLLLLLLALILALLLAALAELELLLLLLLvllLLLLLLLLLLLLLLRLLL 207
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 158 SPELLLDSQDINGEYLNLRVRFALIRRESGFISGLVAVLHDTTEQEKEERERRL-----------------------FVS 214
Cdd:COG4251 208 ELLLLLEAELLLSLGGGLGLLLLLLLLLVLLLLLILLLLLLILVLELLELRLELeeleeeleertaelersneeleqFAY 287
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 215 NVSHELRTPLTSVKSYLEALDE--GALCETVAPDFIKVSLDETNRMMRMVTDLLHLSRIDNATSHLdvELINFTAFITFI 292
Cdd:COG4251 288 VASHDLREPLRKISGFSQLLEEdyGDKLDEEGREYLERIRDAAERMQALIDDLLAYSRVGRQELEF--EPVDLNELLEEV 365
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 293 LnrfDKMKGQEKEKKYELVRDYpinsiWMEIDTDK--MTQVVDNILNNAIKYSPDG--GKITVRMKTTEDQMILSISDHG 368
Cdd:COG4251 366 L---EDLEPRIEERGAEIEVGP-----LPTVRGDPtlLRQVFQNLISNAIKYSRPGepPRIEIGAEREGGEWVFSVRDNG 437
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 892137799 369 LGIPKQDLPRIFDRFYRVDRARSRaqGGTGLGLSIAKEIIKQHKGFIWAKSEYGKGSTFTIVLP 432
Cdd:COG4251 438 IGIDPEYAEKIFEIFQRLHSRDEY--EGTGIGLAIVKKIVERHGGRIWVESEPGEGATFYFTLP 499
|
|
| COG4191 |
COG4191 |
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ... |
213-432 |
6.60e-41 |
|
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];
Pssm-ID: 443345 [Multi-domain] Cd Length: 361 Bit Score: 149.56 E-value: 6.60e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 213 VSNVSHELRTPLTSVKSYLEALDEgALCETVAPDFIKVSLDE----TNRMMRMVTDLLHLSRidnaTSHLDVELINFTAF 288
Cdd:COG4191 146 AAGIAHEINNPLAAILGNAELLRR-RLEDEPDPEELREALERilegAERAAEIVRSLRAFSR----RDEEEREPVDLNEL 220
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 289 ITFILNRfdkMKGQEKEKKYELVRDYPINSIWMEIDTDKMTQVVDNILNNAIKYSPDG--GKITVRMKTTEDQMILSISD 366
Cdd:COG4191 221 IDEALEL---LRPRLKARGIEVELDLPPDLPPVLGDPGQLEQVLLNLLINAIDAMEEGegGRITISTRREGDYVVISVRD 297
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 892137799 367 HGLGIPKQDLPRIFDRFY--RvdrarsRAQGGTGLGLSIAKEIIKQHKGFIWAKSEYGKGSTFTIVLP 432
Cdd:COG4191 298 NGPGIPPEVLERIFEPFFttK------PVGKGTGLGLSISYGIVEKHGGRIEVESEPGGGTTFTITLP 359
|
|
| HATPase |
cd00075 |
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ... |
328-431 |
2.34e-40 |
|
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.
Pssm-ID: 340391 [Multi-domain] Cd Length: 102 Bit Score: 139.66 E-value: 2.34e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 328 MTQVVDNILNNAIKYSPDGGKITVRMKTTEDQMILSISDHGLGIPKQDLPRIFDRFYRVDRARSRaqGGTGLGLSIAKEI 407
Cdd:cd00075 1 LEQVLSNLLDNALKYSPPGGTIEISLRQEGDGVVLEVEDNGPGIPEEDLERIFERFYRGDKSREG--GGTGLGLAIVRRI 78
|
90 100
....*....|....*....|....
gi 892137799 408 IKQHKGFIWAKSEYGKGSTFTIVL 431
Cdd:cd00075 79 VEAHGGRITVESEPGGGTTFTVTL 102
|
|
| cztS_silS_copS |
TIGR01386 |
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ... |
212-432 |
8.36e-40 |
|
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.
Pssm-ID: 273593 [Multi-domain] Cd Length: 457 Bit Score: 148.69 E-value: 8.36e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 212 FVSNVSHELRTPLT--------------SVKSYLEALDEgalcetvapdfikvSLDETNRMMRMVTDLLHLSRIDNATSH 277
Cdd:TIGR01386 244 FSADLAHELRTPLTnllgqtqvalsqprTGEEYREVLES--------------NLEELERLSRMVSDMLFLARADNGQLA 309
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 278 LDVELINFTAFITFILNRFDKMKgqEKEKKYELVRdypiNSIWMEIDTDKMTQVVDNILNNAIKYSPDGGKITVRMKTTE 357
Cdd:TIGR01386 310 LERVRLDLAAELAKVAEYFEPLA--EERGVRIRVE----GEGLVRGDPQMFRRAISNLLSNALRHTPDGGTITVRIERRS 383
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 892137799 358 DQMILSISDHGLGIPKQDLPRIFDRFYRVDRARSRAQGGTGLGLSIAKEIIKQHKGFIWAKSEYGKgSTFTIVLP 432
Cdd:TIGR01386 384 DEVRVSVSNPGPGIPPEHLSRLFDRFYRVDPARSNSGEGTGLGLAIVRSIMEAHGGRASAESPDGK-TRFILRFP 457
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
323-433 |
3.14e-39 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 137.01 E-value: 3.14e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 323 IDTDKMTQVVDNILNNAIKYSPDGGKITVRMKTTEDQMILSISDHGLGIPKQDLPRIFDRFYRVDrARSRAQGGTGLGLS 402
Cdd:smart00387 1 GDPDRLRQVLSNLLDNAIKYTPEGGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTD-KRSRKIGGTGLGLS 79
|
90 100 110
....*....|....*....|....*....|.
gi 892137799 403 IAKEIIKQHKGFIWAKSEYGKGSTFTIVLPY 433
Cdd:smart00387 80 IVKKLVELHGGEISVESEPGGGTTFTITLPL 110
|
|
| MtrAB_MtrB |
NF040691 |
MtrAB system histidine kinase MtrB; |
212-432 |
4.44e-39 |
|
MtrAB system histidine kinase MtrB;
Pssm-ID: 468655 [Multi-domain] Cd Length: 507 Bit Score: 147.48 E-value: 4.44e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 212 FVSNVSHELRTPLTSVK--SYLEALDEGALCETVAPdfiKVSL--DETNRMMRMVTDLLHLSRIDNATSHLDVELINFTA 287
Cdd:NF040691 274 FVSDVSHELRTPLTTIRmaADVIHDSRDDFDPATAR---SAELlhTELDRFESLLSDLLEISRFDAGAAELDVEPVDLRP 350
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 288 FITFILnrfDKMKGQEKEKKYELVRDYPINSIWMEIDTDKMTQVVDNILNNAIKYSpDGGKITVRMKTTEDQMILSISDH 367
Cdd:NF040691 351 LVRRVV---DALRQLAERAGVELRVDAPGTPVVAEVDPRRVERVLRNLVVNAIEHG-EGKPVVVTVAQDDTAVAVTVRDH 426
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 892137799 368 GLGIPKQDLPRIFDRFYRVDRARSRAQGGTGLGLSIAKEIIKQHKGFIWAKSEYGKGSTFTIVLP 432
Cdd:NF040691 427 GVGLKPGEVALVFDRFWRADPARARTTGGTGLGLAIALEDARLHGGWLEAWGRPGQGSQFRLTLP 491
|
|
| PRK09835 |
PRK09835 |
Cu(+)/Ag(+) sensor histidine kinase; |
212-432 |
1.45e-38 |
|
Cu(+)/Ag(+) sensor histidine kinase;
Pssm-ID: 182101 [Multi-domain] Cd Length: 482 Bit Score: 145.69 E-value: 1.45e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 212 FVSNVSHELRTPLTSvksyLEALDEGALCETVAP----DFIKVSLDETNRMMRMVTDLLHLSRIDNATSHLDVELINFTA 287
Cdd:PRK09835 265 FSADIAHEIRTPITN----LITQTEIALSQSRSQkeleDVLYSNLEELTRMAKMVSDMLFLAQADNNQLIPEKKMLDLAD 340
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 288 FITFILNRFDKMkGQEKEKKYELVRDYPinsiWMEIDTDKMTQVVDNILNNAIKYSPDGGKITVRMKTTEDQMILSISDH 367
Cdd:PRK09835 341 EVGKVFDFFEAW-AEERGVELRFVGDPC----QVAGDPLMLRRAISNLLSNALRYTPAGEAITVRCQEVDHQVQLVVENP 415
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 892137799 368 GLGIPKQDLPRIFDRFYRVDRARSRAQGGTGLGLSIAKEIIKQHKGFIWAKSEyGKGSTFTIVLP 432
Cdd:PRK09835 416 GTPIAPEHLPRLFDRFYRVDPSRQRKGEGSGIGLAIVKSIVVAHKGTVAVTSD-ARGTRFVISLP 479
|
|
| KinA |
COG5805 |
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ... |
86-432 |
9.77e-34 |
|
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444507 [Multi-domain] Cd Length: 496 Bit Score: 132.55 E-value: 9.77e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 86 QENLEQESKRLNSILFYMTDGVLATNRRGQIIMINDTAKKQLGLVKEDVLNRSILELLKIEENYELRDLITQSPELLLDS 165
Cdd:COG5805 149 EEILQEQEERLQTLIENSPDLICVIDTDGRILFINESIERLFGAPREELIGKNLLELLHPCDKEEFKERIESITEVWQEF 228
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 166 Q------DINGEYLNLRVRFALIRRESGFISGLVAVLHDTTEQEKEERERRLF---------VSNVSHELRTPLTSVKSY 230
Cdd:COG5805 229 IiereiiTKDGRIRYFEAVIVPLIDTDGSVKGILVILRDITEKKEAEELMARSeklsiagqlAAGIAHEIRNPLTSIKGF 308
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 231 LEALDEGALCETvapDFIKVSLDETNRMMRMVTDLLHLSRIDNAtsHLDVELIN--FTAFITFilnrfdkMKGQEKEKKY 308
Cdd:COG5805 309 LQLLQPGIEDKE---EYFDIMLSELDRIESIISEFLALAKPQAV--NKEKENINelIQDVVTL-------LETEAILHNI 376
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 309 ELVRDYPINSIWMEIDTDKMTQVVDNILNNAIKYSPDGGKITVRMKTTEDQMILSISDHGLGIPKQDLPRIFDRFYrvdr 388
Cdd:COG5805 377 QIRLELLDEDPFIYCDENQIKQVFINLIKNAIEAMPNGGTITIHTEEEDNSVIIRVIDEGIGIPEERLKKLGEPFF---- 452
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 892137799 389 arSRAQGGTGLGLSIAKEIIKQHKGFIWAKSEYGKGSTFTIVLP 432
Cdd:COG5805 453 --TTKEKGTGLGLMVSYKIIENHNGTIDIDSKVGKGTTFTITLP 494
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
324-435 |
1.02e-33 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 122.48 E-value: 1.02e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 324 DTDKMTQVVDNILNNAIKYSPDGGKITVRMKTtEDQMILSISDHGLGIPKQDLPRIFDRFYRVDrarSRAQGGTGLGLSI 403
Cdd:pfam02518 2 DELRLRQVLSNLLDNALKHAAKAGEITVTLSE-GGELTLTVEDNGIGIPPEDLPRIFEPFSTAD---KRGGGGTGLGLSI 77
|
90 100 110
....*....|....*....|....*....|..
gi 892137799 404 AKEIIKQHKGFIWAKSEYGKGSTFTIVLPYDK 435
Cdd:pfam02518 78 VRKLVELLGGTITVESEPGGGTTVTLTLPLAQ 109
|
|
| PRK10364 |
PRK10364 |
two-component system sensor histidine kinase ZraS; |
216-432 |
4.16e-33 |
|
two-component system sensor histidine kinase ZraS;
Pssm-ID: 236674 [Multi-domain] Cd Length: 457 Bit Score: 129.91 E-value: 4.16e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 216 VSHELRTPLTSVKSYLEALDEGALCETVAPDFIKVSLDETNRMMRMVTDLLHLSRidnaTSHLDVELINFTAFITFILnr 295
Cdd:PRK10364 244 VAHEIRNPLSSIKGLAKYFAERAPAGGEAHQLAQVMAKEADRLNRVVSELLELVK----PTHLALQAVDLNDLINHSL-- 317
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 296 fdKMKGQEKEKKyELVRDYPINSIWMEI--DTDKMTQVVDNILNNAIKYSPDGGKITVRMKTTEDQMILSISDHGLGIPK 373
Cdd:PRK10364 318 --QLVSQDANSR-EIQLRFTANDTLPEIqaDPDRLTQVLLNLYLNAIQAIGQHGVISVTASESGAGVKISVTDSGKGIAA 394
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 892137799 374 QDLPRIFDRFYrvdraRSRAQgGTGLGLSIAKEIIKQHKGFIWAKSEYGKGSTFTIVLP 432
Cdd:PRK10364 395 DQLEAIFTPYF-----TTKAE-GTGLGLAVVHNIVEQHGGTIQVASQEGKGATFTLWLP 447
|
|
| PRK09303 |
PRK09303 |
histidine kinase; |
216-432 |
5.22e-33 |
|
histidine kinase;
Pssm-ID: 236462 [Multi-domain] Cd Length: 380 Bit Score: 128.15 E-value: 5.22e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 216 VSHELRTPLTSVKSYLEAL------DEGALCETVAPDFIKVSLDETNRMMRMVTDLLHLSRIDNAT---SHLDVELINFT 286
Cdd:PRK09303 158 LAHDLRTPLTAASLALETLelgqidEDTELKPALIEQLQDQARRQLEEIERLITDLLEVGRTRWEAlrfNPQKLDLGSLC 237
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 287 AFITFIL-NRFdkmkgqeKEKKYELVRDYPINSIWMEIDTDKMTQVVDNILNNAIKYSPDGGKITVRM--KTTEdQMILS 363
Cdd:PRK09303 238 QEVILELeKRW-------LAKSLEIQTDIPSDLPSVYADQERIRQVLLNLLDNAIKYTPEGGTITLSMlhRTTQ-KVQVS 309
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 892137799 364 ISDHGLGIPKQDLPRIFDRFYRVDRarSRAQGGTGLGLSIAKEIIKQHKGFIWAKSEYGKGSTFTIVLP 432
Cdd:PRK09303 310 ICDTGPGIPEEEQERIFEDRVRLPR--DEGTEGYGIGLSVCRRIVRVHYGQIWVDSEPGQGSCFHFTLP 376
|
|
| HATPase_EvgS-ArcB-TorS-like |
cd16922 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ... |
330-432 |
9.97e-33 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340399 [Multi-domain] Cd Length: 110 Bit Score: 119.52 E-value: 9.97e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 330 QVVDNILNNAIKYSPDGGkITVRMKTTED-----QMILSISDHGLGIPKQDLPRIFDRFYRVDRARSRAQGGTGLGLSIA 404
Cdd:cd16922 3 QILLNLLGNAIKFTEEGE-VTLRVSLEEEeedgvQLRFSVEDTGIGIPEEQQARLFEPFSQADSSTTRKYGGTGLGLAIS 81
|
90 100
....*....|....*....|....*...
gi 892137799 405 KEIIKQHKGFIWAKSEYGKGSTFTIVLP 432
Cdd:cd16922 82 KKLVELMGGDISVESEPGQGSTFTFTLP 109
|
|
| AdeS_HK |
NF012226 |
two-component sensor histidine kinase AdeS; Mutations in this component of the two-component ... |
216-432 |
9.55e-32 |
|
two-component sensor histidine kinase AdeS; Mutations in this component of the two-component regulatory system for the AdeABC efflux pump can confer adaptive resistance to certain antibiotics, including tigecycline.
Pssm-ID: 411090 [Multi-domain] Cd Length: 353 Bit Score: 124.34 E-value: 9.55e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 216 VSHELRTPLTSVKSYLEALDEGALceTVAPDFIKVSLDETNRMMRMVTDLLHLSRIDNATSHLDVELINFTAFITFILNR 295
Cdd:NF012226 145 IAHELRTPITILQGRLQGILDGVF--EPDPALFKSLLNQVEGLSHLVEDLRTLSLVENQQLRLNYESVDLKDSIEKVLKM 222
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 296 FdkmkgQEKEKKYELVRDYPINSIWMEIDTDKMTQVVDNILNNAIKYSpDGGKITVRMKTTEDQMILSISDHGLGIPKQD 375
Cdd:NF012226 223 F-----EDRLEQAQLTIVLNLTATPVFCDRRRIEQVLIALIDNAIRYA-NAGKLKISSSVIQDDWILQIEDEGPGIAEEY 296
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 376 LPRIFDRFYRVDRARSRAQGGTGLGLSIAKEIIKQHKGFIwaksEYGK---GSTFTIVLP 432
Cdd:NF012226 297 QQDLFNPFFRLEQSRNKEFGGTGLGLAVVHAIVIAHKGSI----EYSNsqgNSVFTIKLP 352
|
|
| HATPase_EcPhoR-like |
cd16952 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
334-432 |
4.46e-31 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.
Pssm-ID: 340428 [Multi-domain] Cd Length: 108 Bit Score: 115.38 E-value: 4.46e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 334 NILNNAIKYSPDGGKITVRMKTTEDQMILSISDHGLGIPKQDLPRIFDRFYRVDRARSRAQGGTGLGLSIAKEIIKQHKG 413
Cdd:cd16952 7 NLVSNAVKYTPPSDTITVRWSQEESGARLSVEDTGPGIPPEHIPRLTERFYRVDIERCRNTGGTGLGLAIVKHVMSRHDA 86
|
90
....*....|....*....
gi 892137799 414 FIWAKSEYGKGSTFTIVLP 432
Cdd:cd16952 87 RLLIASELGKGSRFTCLFP 105
|
|
| PRK11100 |
PRK11100 |
sensory histidine kinase CreC; Provisional |
212-432 |
1.33e-30 |
|
sensory histidine kinase CreC; Provisional
Pssm-ID: 236846 [Multi-domain] Cd Length: 475 Bit Score: 123.03 E-value: 1.33e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 212 FVSNVSHELRTPLTSVKSYLEALDEGALCETVApDFIKVSLDETNRMMRMVTDLLHLSRIDNATSHLDVELINFTAFITF 291
Cdd:PRK11100 259 YVQTLTHELKSPLAAIRGAAELLQEDPPPEDRA-RFTGNILTQSARLQQLIDRLLELARLEQRQELEVLEPVALAALLEE 337
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 292 ILNRFDkmkGQEKEKKYELVRDypINSIWMEIDTDKMTQVVDNILNNAIKYSPDGGKITVRMKTTEDQMILSISDHGLGI 371
Cdd:PRK11100 338 LVEARE---AQAAAKGITLRLR--PDDARVLGDPFLLRQALGNLLDNAIDFSPEGGTITLSAEVDGEQVALSVEDQGPGI 412
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 892137799 372 PKQDLPRIFDRFY---RVDRARSraqgGTGLGLSIAKEIIKQHKGFIWAKSEYGKGSTFTIVLP 432
Cdd:PRK11100 413 PDYALPRIFERFYslpRPANGRK----STGLGLAFVREVARLHGGEVTLRNRPEGGVLATLTLP 472
|
|
| HATPase_CpxA-like |
cd16949 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
330-432 |
1.66e-30 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.
Pssm-ID: 340425 [Multi-domain] Cd Length: 104 Bit Score: 113.57 E-value: 1.66e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 330 QVVDNILNNAIKYSPdgGKITVRMKTTEDQMILSISDHGLGIPKQDLPRIFDRFYRVDRARSRAQGGTGLGLSIAKEIIK 409
Cdd:cd16949 3 RALENVLRNALRYSP--SKILLDISQDGDQWTITITDDGPGVPEDQLEQIFLPFYRVDSARDRESGGTGLGLAIAERAIE 80
|
90 100
....*....|....*....|...
gi 892137799 410 QHKGFIWAKSEYGKGSTFTIVLP 432
Cdd:cd16949 81 QHGGKIKASNRKPGGLRVRIWLP 103
|
|
| PRK10549 |
PRK10549 |
two-component system sensor histidine kinase BaeS; |
212-436 |
2.05e-29 |
|
two-component system sensor histidine kinase BaeS;
Pssm-ID: 182539 [Multi-domain] Cd Length: 466 Bit Score: 119.74 E-value: 2.05e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 212 FVSNVSHELRTPLTSVKSYLEALDEGALCETvaPDFIKVSLDETNRMMRMVTDLLHLSRIDNATSHLDVELINFTAFITF 291
Cdd:PRK10549 243 FMADISHELRTPLAVLRGELEAIQDGVRKFT--PESVASLQAEVGTLTKLVDDLHQLSLSDEGALAYRKTPVDLVPLLEV 320
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 292 ILNRFdkmKGQEKEKKYELVRDYPINSIwMEIDTDKMTQVVDNILNNAIKYSPDGGKITVRMKTTEDQMILSISDHGLGI 371
Cdd:PRK10549 321 AGGAF---RERFASRGLTLQLSLPDSAT-VFGDPDRLMQLFNNLLENSLRYTDSGGSLHISAEQRDKTLRLTFADSAPGV 396
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 892137799 372 PKQDLPRIFDRFYRVDRARSRAQGGTGLGLSIAKEIIKQHKGFIWAK-SEYGkGSTFTIVLPYDKD 436
Cdd:PRK10549 397 SDEQLQKLFERFYRTEGSRNRASGGSGLGLAICLNIVEAHNGRIIAAhSPFG-GVSITVELPLERD 461
|
|
| cpxA |
PRK09470 |
envelope stress sensor histidine kinase CpxA; |
213-432 |
3.98e-28 |
|
envelope stress sensor histidine kinase CpxA;
Pssm-ID: 236532 [Multi-domain] Cd Length: 461 Bit Score: 115.80 E-value: 3.98e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 213 VSNVSHELRTPLTSVKSYLeAL--------DEGALCETvapdfikvsldETNRMMRMVTDLLHLSRIdNATSHLDVELIn 284
Cdd:PRK09470 247 LSDISHELRTPLTRLQLAT-ALlrrrqgesKELERIET-----------EAQRLDSMINDLLVLSRN-QQKNHLERETF- 312
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 285 ftafitfilnrfdkmkgqekekkyelvrdyPINSIWMEIDTD---------KMTQV-------------------VDNIL 336
Cdd:PRK09470 313 ------------------------------KANSLWSEVLEDakfeaeqmgKSLTVsappgpwpingnpnalasaLENIV 362
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 337 NNAIKYSPDggKITVRMKTTEDQMILSISDHGLGIPKQDLPRIFDRFYRVDRARSRAQGGTGLGLSIAKEIIKQHKGFIW 416
Cdd:PRK09470 363 RNALRYSHT--KIEVAFSVDKDGLTITVDDDGPGVPEEEREQIFRPFYRVDEARDRESGGTGLGLAIVENAIQQHRGWVK 440
|
250
....*....|....*..
gi 892137799 417 A-KSEYGkGSTFTIVLP 432
Cdd:PRK09470 441 AeDSPLG-GLRLTIWLP 456
|
|
| HATPase_BceS-YxdK-YvcQ-like |
cd16948 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
325-432 |
1.01e-27 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.
Pssm-ID: 340424 [Multi-domain] Cd Length: 109 Bit Score: 106.22 E-value: 1.01e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 325 TDK--MTQVVDNILNNAIKYSPDGGKITVRMKTTEDQMILSISDHGLGIPKQDLPRIFDRFYRVDRARsRAQGGTGLGLS 402
Cdd:cd16948 1 TDAkwLSFIIGQIVSNALKYSKQGGKIEIYSETNEQGVVLSIKDFGIGIPEEDLPRVFDKGFTGENGR-NFQESTGMGLY 79
|
90 100 110
....*....|....*....|....*....|..
gi 892137799 403 IAKEIIKQ--HKgfIWAKSEYGKGSTFTIVLP 432
Cdd:cd16948 80 LVKKLCDKlgHK--IDVESEVGEGTTFTITFP 109
|
|
| BaeS_SmeS |
NF012163 |
sensor histidine kinase efflux regulator BaeS; |
212-432 |
6.56e-27 |
|
sensor histidine kinase efflux regulator BaeS;
Pssm-ID: 411086 [Multi-domain] Cd Length: 457 Bit Score: 112.23 E-value: 6.56e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 212 FVSNVSHELRTPLTSVKSYLEALDEGAlcETVAPDFIKVSLDETNRMMRMVTDLLHLSRIDNATSHLDVELINftaFITF 291
Cdd:NF012163 243 FMADISHELRTPLAVLRAELEAIQDGI--RKFTPESLDSLQAEVGTLTKLVDDLHDLSMSDEGALAYQKASVD---LVPL 317
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 292 ILNRFDKMKGQEKEKKYELVRDYPiNSIWMEIDTDKMTQVVDNILNNAIKYSPDGGKITVRMKTTEDQMILSISDHGLGI 371
Cdd:NF012163 318 LEVEGGAFRERFASAGLELEVSLP-DSSLVFGDRDRLMQLFNNLLENSLRYTDSGGSLHISASQRPKEVTLTVADSAPGV 396
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 892137799 372 PKQDLPRIFDRFYRVDRARSRAQGGTGLGLSIAKEIIKQHKGFI-WAKSEYGkGSTFTIVLP 432
Cdd:NF012163 397 SDEQLARLFERFYRVEVSRNRASGGSGLGLAISLNIVQAHGGTLhAAHSPLG-GLRIVVTLP 457
|
|
| HATPase_TutC-TodS-like |
cd16925 |
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ... |
324-432 |
1.26e-26 |
|
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.
Pssm-ID: 340402 [Multi-domain] Cd Length: 110 Bit Score: 103.34 E-value: 1.26e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 324 DTDKMTQVVDNILNNAIKYSPDGGKITVRM-KTTEDQMILSISDHGLGIPKQDLPRIFDRFYRVDRARSRAQGGTGLGLS 402
Cdd:cd16925 1 DAEKYERVVLNLLSNAFKFTPDGGRIRCILeKFRLNRFLLTVSDSGPGIPPNLREEIFERFRQGDGSSTRAHGGTGLGLS 80
|
90 100 110
....*....|....*....|....*....|
gi 892137799 403 IAKEIIKQHKGFIWAKSEYGKGSTFTIVLP 432
Cdd:cd16925 81 IVKEFVELHGGTVTVSDAPGGGALFQVELP 110
|
|
| HATPase_BaeS-like |
cd16946 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
324-432 |
1.30e-26 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.
Pssm-ID: 340422 [Multi-domain] Cd Length: 109 Bit Score: 103.31 E-value: 1.30e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 324 DTDKMTQVVDNILNNAIKYSPDGGKITVRMKTTEDQMILSISDHGLGIPKQDLPRIFDRFYRVDRARSRAQGGTGLGLSI 403
Cdd:cd16946 1 DRDRLQQLFVNLLENSLRYTDTGGKLRIRAAQTPQEVRLDVEDSAPGVSDDQLARLFERFYRVESSRNRASGGSGLGLAI 80
|
90 100 110
....*....|....*....|....*....|
gi 892137799 404 AKEIIKQHKGFIWAK-SEYGkGSTFTIVLP 432
Cdd:cd16946 81 CHNIALAHGGTISAEhSPLG-GLRLVLTLP 109
|
|
| HATPase_AtoS-like |
cd16943 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
330-432 |
2.79e-26 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.
Pssm-ID: 340419 [Multi-domain] Cd Length: 105 Bit Score: 102.12 E-value: 2.79e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 330 QVVDNILNNAIKYSPDGGKITVRMKTTEDQMILSISDHGLGIPKQDLPRIFDRFYRVDRARSraqgGTGLGLSIAKEIIK 409
Cdd:cd16943 6 QVLLNLLVNAAQAMEGRGRITIRTWAHVDQVLIEVEDTGSGIDPEILGRIFDPFFTTKPVGE----GTGLGLSLSYRIIQ 81
|
90 100
....*....|....*....|...
gi 892137799 410 QHKGFIWAKSEYGKGSTFTIVLP 432
Cdd:cd16943 82 KHGGTIRVASVPGGGTRFTIILP 104
|
|
| TMAO_torS |
TIGR02956 |
TMAO reductase sytem sensor TorS; This protein, TorS, is part of a regulatory system for the ... |
212-434 |
1.54e-23 |
|
TMAO reductase sytem sensor TorS; This protein, TorS, is part of a regulatory system for the torCAD operon that encodes the pterin molybdenum cofactor-containing enzyme trimethylamine-N-oxide (TMAO) reductase (TorA), a cognate chaperone (TorD), and a penta-haem cytochrome (TorC). TorS works together with the inducer-binding protein TorT and the response regulator TorR. TorS contains histidine kinase ATPase (pfam02518), HAMP (pfam00672), phosphoacceptor (pfam00512), and phosphotransfer (pfam01627) domains and a response regulator receiver domain (pfam00072). [Signal transduction, Two-component systems]
Pssm-ID: 274362 [Multi-domain] Cd Length: 968 Bit Score: 104.09 E-value: 1.54e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 212 FVSNVSHELRTPLTSVKSYLEALDEGALCETVApDFIKVSLDETNRMMRMVTDLLHLSRIDnaTSHLDVELINFT--AFI 289
Cdd:TIGR02956 467 FLATMSHEIRTPLNGILGTLELLGDTGLTSQQQ-QYLQVINRSGESLLDILNDILDYSKIE--AGHLSISPRPFDlnALL 543
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 290 TFILNRfdkMKGQEKEKKYELVRDYPIN-SIWMEIDTDKMTQVVDNILNNAIKYSpDGGKITVRMKTTEDQMIL-SISDH 367
Cdd:TIGR02956 544 DDVHHL---MVSRAQLKGIQLRLNIPEQlPNWWQGDGPRIRQVLINLVGNAIKFT-DRGSVVLRVSLNDDSSLLfEVEDT 619
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 892137799 368 GLGIPKQDLPRIFDRFYRVDRARSraQGGTGLGLSIAKEIIKQHKGFIWAKSEYGKGSTFTIVLPYD 434
Cdd:TIGR02956 620 GCGIAEEEQATLFDAFTQADGRRR--SGGTGLGLAISQRLVEAMDGELGVESELGVGSCFWFTLPLT 684
|
|
| PRK10604 |
PRK10604 |
sensor protein RstB; Provisional |
215-432 |
1.14e-22 |
|
sensor protein RstB; Provisional
Pssm-ID: 236724 [Multi-domain] Cd Length: 433 Bit Score: 99.68 E-value: 1.14e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 215 NVSHELRTPLTSVKSYLEALDEGALCETVApdfIKVSLDETNRMmrmVTDLLHLSRIDNATSHLDVELINFTAFITFILN 294
Cdd:PRK10604 218 GIAHELRTPLVRLRYRLEMSDNLSAAESQA---LNRDIGQLEAL---IEELLTYARLDRPQNELHLSEPDLPAWLSTHLA 291
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 295 RFDKMkgqEKEKKYELVRdyPINSIWMEIDTDKMTQVVDNILNNAIKYSpdGGKITVRMKTTEDQMILSISDHGLGIPKQ 374
Cdd:PRK10604 292 DIQAV---TPEKTVRLDT--PHQGDYGALDMRLMERVLDNLLNNALRYA--HSRVRVSLLLDGNQACLIVEDDGPGIPPE 364
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 892137799 375 DLPRIFDRFYRVDRARSRAQGGTGLGLSIAKEIIKQHKGFIWAKSEYGKGSTFTIVLP 432
Cdd:PRK10604 365 ERERVFEPFVRLDPSRDRATGGCGLGLAIVHSIALAMGGSVNCDESELGGARFSFSWP 422
|
|
| KinB |
COG5806 |
Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome ... |
216-433 |
1.80e-22 |
|
Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444508 [Multi-domain] Cd Length: 412 Bit Score: 98.79 E-value: 1.80e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 216 VSHELRTPLTSVKSYLEALDEGALCETVAPDFIKVSLDETNRMMRMVTDLLHLSR--IDNaTSHLDVELInfTAFITFIL 293
Cdd:COG5806 208 IAHEVRNPLTVVRGFIQLLQEPELSDEKRKQYIRIALEELDRAEAIITDYLTFAKpqPEK-LEKIDVSEE--LEHVIDVL 284
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 294 NRFDKMKGQEkekkyelVRDYPINSIWMEIDTDKMTQVVDNILNNAIKYSPDGGKITVRMKTTEDQMILSISDHGLGIPK 373
Cdd:COG5806 285 SPYANMNNVE-------IQTELEPGLYIEGDRQKLQQCLINIIKNGIEAMPNGGTLTIDVSIDKNKVIISIKDTGVGMTK 357
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 374 QDLPRIFDRFYrvdrarSRAQGGTGLGLSIAKEIIKQHKGFIWAKSEYGKGSTFTIVLPY 433
Cdd:COG5806 358 EQLERLGEPYF------STKEKGTGLGTMVSYRIIEAMNGTIRVESEVGKGTTFTITLPL 411
|
|
| PRK11091 |
PRK11091 |
aerobic respiration control sensor protein ArcB; Provisional |
212-432 |
2.36e-22 |
|
aerobic respiration control sensor protein ArcB; Provisional
Pssm-ID: 236842 [Multi-domain] Cd Length: 779 Bit Score: 100.02 E-value: 2.36e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 212 FVSNVSHELRTPLTSVKSYLEALDEGAL-------CETvapdfIKVSldetnrmmrMVT------DLLHLSRIDNATSHL 278
Cdd:PRK11091 286 FISTISHELRTPLNGIVGLSRILLDTELtaeqrkyLKT-----IHVS---------AITlgnifnDIIDMDKMERRKLQL 351
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 279 DVELINFTAFITFILNrFDKMKGQEKEKKYELVRDYPInSIWMEIDTDKMTQVVDNILNNAIKYSPDGGkITVRM-KTTE 357
Cdd:PRK11091 352 DNQPIDFTDFLADLEN-LSGLQAEQKGLRFDLEPLLPL-PHKVITDGTRLRQILWNLISNAVKFTQQGG-VTVRVrYEEG 428
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 892137799 358 DQMILSISDHGLGIPKQDLPRIFDRFYRV-DRARSRAQGGTGLGLSIAKEIIKQHKGFIWAKSEYGKGSTFTIVLP 432
Cdd:PRK11091 429 DMLTFEVEDSGIGIPEDELDKIFAMYYQVkDSHGGKPATGTGIGLAVSKRLAQAMGGDITVTSEEGKGSCFTLTIH 504
|
|
| PRK09959 |
PRK09959 |
acid-sensing system histidine kinase EvgS; |
212-434 |
5.84e-22 |
|
acid-sensing system histidine kinase EvgS;
Pssm-ID: 182169 [Multi-domain] Cd Length: 1197 Bit Score: 99.42 E-value: 5.84e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 212 FVSNVSHELRTPLTSVKSYLEALDEGALCETVAPDFIKVSLDETNRMMRMVTDLLHLSRIDNATSHLDVELINFTAFITF 291
Cdd:PRK09959 715 FLATMSHEIRTPISSIMGFLELLSGSGLSKEQRVEAISLAYATGQSLLGLIGEILDVDKIESGNYQLQPQWVDIPTLVQN 794
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 292 ILNRFDKMKGQeKEKKYELVRDYPiNSIWMEIDTDKMTQVVDNILNNAIKYSPDGG-KITVRMKTTEDQ---MILSISDH 367
Cdd:PRK09959 795 TCHSFGAIAAS-KSIALSCSSTFP-DHYLVKIDPQAFKQVLSNLLSNALKFTTEGAvKITTSLGHIDDNhavIKMTIMDS 872
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 892137799 368 GLGIPKQDLPRIFDRFYRVdrARSRAQGGTGLGLSIAKEIIKQHKGFIWAKSEYGKGSTFTIVLPYD 434
Cdd:PRK09959 873 GSGLSQEEQQQLFKRYSQT--SAGRQQTGSGLGLMICKELIKNMQGDLSLESHPGIGTTFTITIPVE 937
|
|
| CitA |
COG3290 |
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ... |
1-436 |
7.09e-22 |
|
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];
Pssm-ID: 442519 [Multi-domain] Cd Length: 389 Bit Score: 96.84 E-value: 7.09e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 1 MLDLLKQTIFTRDFIFILILLGFILVVTLLLLENRRDNIQLKQINQKVKDLIAGDYSKVLDMqggseitnitnnLNDLSE 80
Cdd:COG3290 3 LLLLLLLLLLILLILILILLLLLLIILLLILLLVLLLLLFLLFVIILLLLLLILLLILLLLL------------LLLLAA 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 81 VIRLTQENLEQESKRLNSILFYMTDGVLATNRRGQIIMINDTAKKQLGLvkeDVLNRSILELLKIEENYELRDLItqspe 160
Cdd:COG3290 71 LLLKLLEEIARLVEEREAVLESIREGVIAVDRDGRITLINDAARRLLGL---DAIGRPIDEVLAEVLETGERDEE----- 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 161 llldsQDINGEYLNLRVRFAlirRESGFISGLVAVLHDTTEQekeererrlfvsnvsHELRTPLTSVKSYLEALdegalc 240
Cdd:COG3290 143 -----ILLNGRVLVVNRVPI---RDDGRVVGAVATFRDRTEL---------------ERLEEELEGVKELAEAL------ 193
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 241 etvapdfiKVSLDETNRMMRMVTDLLHLSRIDNATSHLDVELINFTAFITFILNRFD----------KMKgQEKEKKYEL 310
Cdd:COG3290 194 --------RAQRHDFRNHLHTISGLLQLGEYDEALEYIDEISEELQELIDSLLSRIGnpvlaalllgKAA-RARERGIDL 264
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 311 VRDYPINSIWMEIDTDKMTQVVDNILNNAI----KYSPDGGKITVRMKTTEDQMILSISDHGLGIPKQDLPRIFDRFYRv 386
Cdd:COG3290 265 TIDIDSDLPDLPLSDTDLVTILGNLLDNAIeaveKLPEEERRVELSIRDDGDELVIEVEDSGPGIPEELLEKIFERGFS- 343
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|
gi 892137799 387 drarSRAQGGTGLGLSIAKEIIKQHKGFIWAKSEYGKGSTFTIVLPYDKD 436
Cdd:COG3290 344 ----TKLGEGRGLGLALVKQIVEKYGGTIEVESEEGEGTVFTVRLPKEGE 389
|
|
| PRK15347 |
PRK15347 |
two component system sensor kinase; |
215-432 |
1.01e-21 |
|
two component system sensor kinase;
Pssm-ID: 237951 [Multi-domain] Cd Length: 921 Bit Score: 98.18 E-value: 1.01e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 215 NVSHELRTPLTSVKSYLEALDEGALCETVApDFIKVSLDETNRMMRMVTDLLHLSRIDNATSHLDVELinfTAFITFILN 294
Cdd:PRK15347 404 TISHEIRTPLNGVLGALELLQNTPLTAEQM-DLADTARQCTLSLLAIINNLLDFSRIESGQMTLSLEE---TALLPLLDQ 479
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 295 RFDKMKGQEKEKK---YELV-RDYPINsiwMEIDTDKMTQVVDNILNNAIKYSPDGGkITVRMKTTEDQMILSISDHGLG 370
Cdd:PRK15347 480 AMLTIQGPAQSKSltlRTFVgAHVPLY---LHLDSLRLRQILVNLLGNAVKFTETGG-IRLRVKRHEQQLCFTVEDTGCG 555
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 892137799 371 IPKQDLPRIFDRFYRVDrarsRAQGGTGLGLSIAKEIIKQHKGFIWAKSEYGKGSTFTIVLP 432
Cdd:PRK15347 556 IDIQQQQQIFTPFYQAD----THSQGTGLGLTIASSLAKMMGGELTLFSTPGVGSCFSLVLP 613
|
|
| HATPase_FilI-like |
cd16921 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
328-432 |
1.34e-21 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340398 [Multi-domain] Cd Length: 105 Bit Score: 89.31 E-value: 1.34e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 328 MTQVVDNILNNAIKYSPDG--GKITVRMKTTEDQMILSISDHGLGIPKQDLPRIFDRFYRVDrarSRAQ-GGTGLGLSIA 404
Cdd:cd16921 1 LGQVLTNLLGNAIKFRRPRrpPRIEVGAEDVGEEWTFYVRDNGIGIDPEYAEKVFGIFQRLH---SREEyEGTGVGLAIV 77
|
90 100
....*....|....*....|....*...
gi 892137799 405 KEIIKQHKGFIWAKSEYGKGSTFTIVLP 432
Cdd:cd16921 78 RKIIERHGGRIWLESEPGEGTTFYFTLP 105
|
|
| HATPase_VanS-like |
cd16923 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
328-432 |
3.80e-21 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.
Pssm-ID: 340400 [Multi-domain] Cd Length: 102 Bit Score: 87.83 E-value: 3.80e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 328 MTQVVDNILNNAIKYSPDGGKITVRMKTTEDQMILSISDHGLGIPKQDLPRIFDRFYRVDraRSRAQGGTGLGLSIAKEI 407
Cdd:cd16923 1 LQRVFSNLLSNAIKYSPENTRIYITSFLTDDVVNIMFKNPSSHPLDFKLEKLFERFYRGD--NSRNTEGAGLGLSIAKAI 78
|
90 100
....*....|....*....|....*
gi 892137799 408 IKQHKGFIWAKSEyGKGSTFTIVLP 432
Cdd:cd16923 79 IELHGGSASAEYD-DNHDLFKVRLP 102
|
|
| marine_sort_HK |
TIGR03785 |
proteobacterial dedicated sortase system histidine kinase; This histidine kinase protein is ... |
212-432 |
4.68e-21 |
|
proteobacterial dedicated sortase system histidine kinase; This histidine kinase protein is paired with an adjacent response regulator (TIGR03787) gene. It co-occurs with a variant sortase enzyme (TIGR03784), usually in the same gene neighborhood, in proteobacterial species most of which are marine, and with an LPXTG motif-containing sortase target conserved protein (TIGR03788). Sortases and LPXTG proteins are far more common in Gram-positive bacteria, where sortase systems mediate attachment to the cell wall or cross-linking of pilin structures. We give this predicted sensor histidine kinase the gene symbol psdS, for Proteobacterial Dedicated Sortase system Sensor histidine kinase.
Pssm-ID: 163497 [Multi-domain] Cd Length: 703 Bit Score: 95.97 E-value: 4.68e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 212 FVSNVSHELRTPLTSVKSYLEALDEGALcETVAPDFIKVSLDETNRMMRMVTDLLHLSRIDNATSHLDVELINFTAFITf 291
Cdd:TIGR03785 488 MSSRLSHELRTPVAVVRSSLENLELQAL-EQEKQKYLERAREGTERLSMILNNMSEATRLEQAIQSAEVEDFDLSEVLS- 565
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 292 ilnrfdkmkgqEKEKKYELVrdYPINSIWMEIDTDKMT---------QVVDNILNNAIKYSPDGGKITVRMKTTEDQMIL 362
Cdd:TIGR03785 566 -----------GCMQGYQMT--YPPQRFELNIPETPLVmrgspeliaQMLDKLVDNAREFSPEDGLIEVGLSQNKSHALL 632
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 892137799 363 SISDHGLGIPKQDLPRIFDRFYRVdrarsRAQGGT-----GLGLSIAKEIIKQHKGFIWAKSEY-GKGSTFTIVLP 432
Cdd:TIGR03785 633 TVSNEGPPLPEDMGEQLFDSMVSV-----RDQGAQdqphlGLGLYIVRLIADFHQGRIQAENRQqNDGVVFRISLP 703
|
|
| HATPase_BvrS-ChvG-like |
cd16953 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
328-432 |
1.21e-20 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.
Pssm-ID: 340429 [Multi-domain] Cd Length: 110 Bit Score: 86.86 E-value: 1.21e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 328 MTQVVDNILNNAIKYSP-DGGKITVRMKTTEDQMILSISDHGLGIPKQDLPRIFDRFYrVDRARSRAQG-GTGLGLSIAK 405
Cdd:cd16953 1 LGQVLRNLIGNAISFSPpDTGRITVSAMPTGKMVTISVEDEGPGIPQEKLESIFDRFY-TERPANEAFGqHSGLGLSISR 79
|
90 100 110
....*....|....*....|....*....|.
gi 892137799 406 EIIKQHKGFIWAKS----EYGKGSTFTIVLP 432
Cdd:cd16953 80 QIIEAHGGISVAENhnqpGQVIGARFTVQLP 110
|
|
| PRK10490 |
PRK10490 |
sensor protein KdpD; Provisional |
217-435 |
1.96e-20 |
|
sensor protein KdpD; Provisional
Pssm-ID: 236701 [Multi-domain] Cd Length: 895 Bit Score: 94.33 E-value: 1.96e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 217 SHELRTPLTSVKSYLEAL-----DEGALCETVAPDFIKVSLDETnrmmRMVTDLLHLSRIDNATSHLDVELINFTAFITF 291
Cdd:PRK10490 672 SHDLRTPLTVLFGQAEILtldlaSEGSPHARQASEIRQQVLNTT----RLVNNLLDMARIQSGGFNLRKEWLTLEEVVGS 747
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 292 ILNRFDKMKGqekekKYELVRDYPINSIWMEIDTDKMTQVVDNILNNAIKYSPDGGKITVRMKTTEDQMILSISDHGLGI 371
Cdd:PRK10490 748 ALQMLEPGLS-----GHPINLSLPEPLTLIHVDGPLFERVLINLLENAVKYAGAQAEIGIDAHVEGERLQLDVWDNGPGI 822
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 892137799 372 PKQDLPRIFDRFYRVDraRSRAQGGTGLGLSIAKEIIKQHKGFIWAKSEYGKGSTFTIVLPYDK 435
Cdd:PRK10490 823 PPGQEQLIFDKFARGN--KESAIPGVGLGLAICRAIVEVHGGTIWAENRPEGGACFRVTLPLET 884
|
|
| HATPase_CreC-like |
cd16945 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
330-415 |
5.43e-20 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.
Pssm-ID: 340421 [Multi-domain] Cd Length: 106 Bit Score: 84.82 E-value: 5.43e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 330 QVVDNILNNAIKYSPDGGKITVRMKTTEDQMILSISDHGLGIPKQDLPRIFDRFYRVDRARSrAQGGTGLGLSIAKEIIK 409
Cdd:cd16945 7 QAINNLLDNAIDFSPEGGLIALQLEADTEGIELLVFDEGSGIPDYALNRVFERFYSLPRPHS-GQKSTGLGLAFVQEVAQ 85
|
....*.
gi 892137799 410 QHKGFI 415
Cdd:cd16945 86 LHGGRI 91
|
|
| PRK10755 |
PRK10755 |
two-component system sensor histidine kinase PmrB; |
211-413 |
1.55e-19 |
|
two-component system sensor histidine kinase PmrB;
Pssm-ID: 236751 [Multi-domain] Cd Length: 356 Bit Score: 89.64 E-value: 1.55e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 211 LFVSNVSHELRTPLTSVKSYLEaldegaLCETVAPDFIKVSLDETNRMMRMVTDLLHLSRIDNATS---HLDVELINftA 287
Cdd:PRK10755 139 LFTADVAHELRTPLAGIRLHLE------LLEKQHHIDVAPLIARLDQMMHTVEQLLQLARAGQSFSsghYQTVKLLE--D 210
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 288 FITFILNRFDKMKGQekekkyelvRDYPInsIWMEIDTDKMTQ--------VVDNILNNAIKYSPDGGKITVRMKTTEDQ 359
Cdd:PRK10755 211 VILPSQDELSEMLEQ---------RQQTL--LLPESAADITVQgdatllrlLLRNLVENAHRYSPEGSTITIKLSQEDGG 279
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 892137799 360 MILSISDHGLGIPKQDLPRIFDRFYRVDrarSRAqGGTGLGLSIAKEIIKQHKG 413
Cdd:PRK10755 280 AVLAVEDEGPGIDESKCGELSKAFVRMD---SRY-GGIGLGLSIVSRITQLHHG 329
|
|
| HATPase_BasS-like |
cd16940 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
324-413 |
3.10e-19 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.
Pssm-ID: 340417 [Multi-domain] Cd Length: 113 Bit Score: 82.84 E-value: 3.10e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 324 DTDKMTQVVDNILNNAIKYSPDGGKITVRMKTtEDQMILSISDHGLGIPKQDLPRIFDRFYRVDrarSRAQGGTGLGLSI 403
Cdd:cd16940 10 DALLLFLLLRNLVDNAVRYSPQGSRVEIKLSA-DDGAVIRVEDNGPGIDEEELEALFERFYRSD---GQNYGGSGLGLSI 85
|
90
....*....|
gi 892137799 404 AKEIIKQHKG 413
Cdd:cd16940 86 VKRIVELHGG 95
|
|
| PRK11466 |
PRK11466 |
hybrid sensory histidine kinase TorS; Provisional |
212-432 |
1.18e-17 |
|
hybrid sensory histidine kinase TorS; Provisional
Pssm-ID: 236914 [Multi-domain] Cd Length: 914 Bit Score: 85.73 E-value: 1.18e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 212 FVSNVSHELRTPLTSVKSYLEALDEGALCETvAPDFIKVSLDETNRMMRMVTDLLHLSRIDNATSHLDVELINFTAFiTF 291
Cdd:PRK11466 447 FLAAMSHEIRTPLYGILGTAQLLADNPALNA-QRDDLRAITDSGESLLTILNDILDYSAIEAGGKNVSVSDEPFEPR-PL 524
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 292 ILNRFDKMKGQEKEKKYELVRDYPIN-SIWMEIDTDKMTQVVDNILNNAIKYSpDGGKITVRMKTTEDQMILSISDHGLG 370
Cdd:PRK11466 525 LESTLQLMSGRVKGRPIRLATDIADDlPTALMGDPRRIRQVITNLLSNALRFT-DEGSIVLRSRTDGEQWLVEVEDSGCG 603
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 892137799 371 IPKQDLPRIFDRFYRVDRARsraqGGTGLGLSIAKEIIKQHKGFIWAKSEYGKGSTFTIVLP 432
Cdd:PRK11466 604 IDPAKLAEIFQPFVQVSGKR----GGTGLGLTISSRLAQAMGGELSATSTPEVGSCFCLRLP 661
|
|
| PRK10337 |
PRK10337 |
sensor protein QseC; Provisional |
212-411 |
3.50e-17 |
|
sensor protein QseC; Provisional
Pssm-ID: 182388 [Multi-domain] Cd Length: 449 Bit Score: 83.55 E-value: 3.50e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 212 FVSNVSHELRTPLTSVKSYLE----ALDEGALCETvAPDFIKVSLDetnRMMRMVTDLLHLSRIDNATSHLDVELINFTA 287
Cdd:PRK10337 240 FTSDAAHELRSPLAALKVQTEvaqlSDDDPQARKK-ALLQLHAGID---RATRLVDQLLTLSRLDSLDNLQDVAEIPLED 315
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 288 FI-TFILNRFDKMKGQEKEKKYELVRDYPINSIWMEIdtdkMTQVVDNILNNAIKYSPDGGKITVRMKTTEdqmiLSISD 366
Cdd:PRK10337 316 LLqSAVMDIYHTAQQAGIDVRLTLNAHPVIRTGQPLL----LSLLVRNLLDNAIRYSPQGSVVDVTLNARN----FTVRD 387
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 892137799 367 HGLGIPKQDLPRIFDRFYrvdRARSRAQGGTGLGLSIAKEIIKQH 411
Cdd:PRK10337 388 NGPGVTPEALARIGERFY---RPPGQEATGSGLGLSIVRRIAKLH 429
|
|
| HATPase_TmoS-FixL-DctS-like |
cd16920 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
330-432 |
3.77e-17 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340397 [Multi-domain] Cd Length: 104 Bit Score: 76.67 E-value: 3.77e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 330 QVVDNILNNAIK----YSPDGGKITVR-MKTTEDQMILSISDHGLGIPKQDLPRIFDRFYRvdrarSRAQGgTGLGLSIA 404
Cdd:cd16920 3 QVLINLVRNGIEamseGGCERRELTIRtSPADDRAVTISVKDTGPGIAEEVAGQLFDPFYT-----TKSEG-LGMGLSIC 76
|
90 100
....*....|....*....|....*...
gi 892137799 405 KEIIKQHKGFIWAKSEYGKGSTFTIVLP 432
Cdd:cd16920 77 RSIIEAHGGRLSVESPAGGGATFQFTLP 104
|
|
| HATPase_YcbM-like |
cd16947 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
313-431 |
4.07e-17 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).
Pssm-ID: 340423 [Multi-domain] Cd Length: 125 Bit Score: 77.17 E-value: 4.07e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 313 DYPINSIWMEIDTDKMTQVVDNILNNAIKYSPDGGKITVRMKTTEDQMILSISDHGLGIPKQDLPRIFDRFYRVDRARSR 392
Cdd:cd16947 6 NIPDRPIYANANTEALQRILKNLISNAIKYGSDGKFLGMTLREDEKHVYIDIWDKGKGISETEKDHVFERLYTLEDSRNS 85
|
90 100 110
....*....|....*....|....*....|....*....
gi 892137799 393 AQGGTGLGLSIAKEIIKQHKGFIWAKSEYGKGSTFTIVL 431
Cdd:cd16947 86 AKQGNGLGLTITKRLAESMGGSIYVNSKPYEKTVFTVTL 124
|
|
| PRK10841 |
PRK10841 |
two-component system sensor histidine kinase RcsC; |
211-432 |
4.18e-17 |
|
two-component system sensor histidine kinase RcsC;
Pssm-ID: 182772 [Multi-domain] Cd Length: 924 Bit Score: 84.25 E-value: 4.18e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 211 LFVSNVSHELRTPLTSVKSYLEALDEGALCETVApDFIKVSLDETNRMMRMVTDLLHLSRIDnaTSHLDVELINFTA--F 288
Cdd:PRK10841 449 MFLATVSHELRTPLYGIIGNLDLLQTKELPKGVD-RLVTAMNNSSSLLLKIISDILDFSKIE--SEQLKIEPREFSPreV 525
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 289 ITFILNRFDKMKGQEKEKKYELVR-DYPinsiwMEIDTDKM--TQVVDNILNNAIKYSpDGGKITVRMKTTEDQMILSIS 365
Cdd:PRK10841 526 INHITANYLPLVVKKRLGLYCFIEpDVP-----VALNGDPMrlQQVISNLLSNAIKFT-DTGCIVLHVRVDGDYLSFRVR 599
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 892137799 366 DHGLGIPKQDLPRIFDRFYRVDRARSRAQGGTGLGLSIAKEIIKQHKGFIWAKSEYGKGSTFTIVLP 432
Cdd:PRK10841 600 DTGVGIPAKEVVRLFDPFFQVGTGVQRNFQGTGLGLAICEKLINMMDGDISVDSEPGMGSQFTIRIP 666
|
|
| HATPase_EnvZ-like |
cd16950 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
328-432 |
9.31e-17 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.
Pssm-ID: 340426 [Multi-domain] Cd Length: 101 Bit Score: 75.56 E-value: 9.31e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 328 MTQVVDNILNNAIKYSpdGGKITVRMKTTEDQMILSISDHGLGIPKQDLPRIFDRFYRVDRARSraQGGTGLGLSIAKEI 407
Cdd:cd16950 1 LKRVLSNLVDNALRYG--GGWVEVSSDGEGNRTRIQVLDNGPGIAPEEVDELFQPFYRGDNARG--TSGTGLGLAIVQRI 76
|
90 100
....*....|....*....|....*
gi 892137799 408 IKQHKGFIWAKSEYGKGSTFTIVLP 432
Cdd:cd16950 77 SDAHGGSLTLANRAGGGLCARIELP 101
|
|
| PRK13837 |
PRK13837 |
two-component system VirA-like sensor kinase; |
330-432 |
2.95e-16 |
|
two-component system VirA-like sensor kinase;
Pssm-ID: 237526 [Multi-domain] Cd Length: 828 Bit Score: 81.26 E-value: 2.95e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 330 QVVDNILNNAIKYSPDGGKITVRMK---------------TTEDQMILSISDHGLGIPKQDLPRIFDRFYRvdrarSRAq 394
Cdd:PRK13837 563 QVLMNLCSNAAQAMDGAGRVDISLSraklrapkvlshgvlPPGRYVLLRVSDTGAGIDEAVLPHIFEPFFT-----TRA- 636
|
90 100 110
....*....|....*....|....*....|....*...
gi 892137799 395 GGTGLGLSIAKEIIKQHKGFIWAKSEYGKGSTFTIVLP 432
Cdd:PRK13837 637 GGTGLGLATVHGIVSAHAGYIDVQSTVGRGTRFDVYLP 674
|
|
| HATPase_RstB-like |
cd16939 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
328-432 |
3.88e-16 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.
Pssm-ID: 340416 [Multi-domain] Cd Length: 104 Bit Score: 74.00 E-value: 3.88e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 328 MTQVVDNILNNAIKYSpdggKITVRMKTT--EDQMILSISDHGLGIPKQDLPRIFDRFYRVDRARSRAQGGTGLGLSIAK 405
Cdd:cd16939 1 MARALDNLLRNALRYA----HRTVRIALLvsGGRLTLIVEDDGPGIPAAARERVFEPFVRLDPSRDRATGGFGLGLAIVH 76
|
90 100
....*....|....*....|....*...
gi 892137799 406 EIIKQHKGFIWA-KSEYGkGSTFTIVLP 432
Cdd:cd16939 77 RVALWHGGHVECdDSELG-GACFRLTWP 103
|
|
| glnL |
PRK11073 |
nitrogen regulation protein NR(II); |
211-432 |
1.26e-15 |
|
nitrogen regulation protein NR(II);
Pssm-ID: 182947 [Multi-domain] Cd Length: 348 Bit Score: 77.81 E-value: 1.26e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 211 LFVSNVSHELRTPLTSVKSYLEALdEGALCETVAPDFIKVSLDETNRMMRMVTDLLHLSRIDNATSHldvelinftaFIT 290
Cdd:PRK11073 132 DLVRGLAHEIKNPLGGLRGAAQLL-SKALPDPALTEYTKVIIEQADRLRNLVDRLLGPQRPGTHVTE----------SIH 200
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 291 FILNRFDKMKGQEKEKKYELVRDYPINSIWMEIDTDKMTQVVDNILNNAIK-YSPDGGKITVRMKTTEDQMI-------- 361
Cdd:PRK11073 201 KVAERVVQLVSLELPDNVRLIRDYDPSLPELAHDPDQIEQVLLNIVRNALQaLGPEGGTITLRTRTAFQLTLhgeryrla 280
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 892137799 362 --LSISDHGLGIPkqdlPRIFDR-FYRVDRARsraQGGTGLGLSIAKEIIKQHKGFIWAKSEYGKgSTFTIVLP 432
Cdd:PRK11073 281 arIDIEDNGPGIP----PHLQDTlFYPMVSGR---EGGTGLGLSIARNLIDQHSGKIEFTSWPGH-TEFSVYLP 346
|
|
| HATPase_SpaK_NisK-like |
cd16975 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
324-415 |
3.64e-15 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.
Pssm-ID: 340434 [Multi-domain] Cd Length: 107 Bit Score: 71.34 E-value: 3.64e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 324 DTDKMTQVVDNILNNAIKYSPDGGKITVRMKTTEDQMILSISDHGLGIPKQDLPRIFDRFYRVDRARsRAQGGTGLGLSI 403
Cdd:cd16975 1 DTLLLSRALINIISNACQYAPEGGTVSISIYDEEEYLYFEIWDNGHGFSEQDLKKALELFYRDDTSR-RSGGHYGMGLYI 79
|
90
....*....|..
gi 892137799 404 AKEIIKQHKGFI 415
Cdd:cd16975 80 AKNLVEKHGGSL 91
|
|
| envZ |
PRK09467 |
osmolarity sensor protein; Provisional |
216-415 |
6.88e-15 |
|
osmolarity sensor protein; Provisional
Pssm-ID: 236531 [Multi-domain] Cd Length: 435 Bit Score: 76.10 E-value: 6.88e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 216 VSHELRTPLTSVKSYLEAL--DEGALCETVAPDfikvsLDETNRMMRMVTDLLhlsRIDNATShldVELINFTAFITFIL 293
Cdd:PRK09467 236 VSHDLRTPLTRIRLATEMMseEDGYLAESINKD-----IEECNAIIEQFIDYL---RTGQEMP---MEMADLNALLGEVI 304
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 294 NRFDKMKGQEKEKKYELVRDYPINSIwmeidtdKMTQVVDNILNNAIKYSpdGGKITVRMKTTEDQMILSISDHGLGIPK 373
Cdd:PRK09467 305 AAESGYEREIETALQPGPIEVPMNPI-------AIKRALANLVVNAARYG--NGWIKVSSGTEGKRAWFQVEDDGPGIPP 375
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 892137799 374 QDLPRIFDRFYRVDRARSRAqgGTGLGLSIAKEIIKQHKGFI 415
Cdd:PRK09467 376 EQLKHLFQPFTRGDSARGSS--GTGLGLAIVKRIVDQHNGKV 415
|
|
| PRK11107 |
PRK11107 |
hybrid sensory histidine kinase BarA; Provisional |
324-434 |
1.46e-14 |
|
hybrid sensory histidine kinase BarA; Provisional
Pssm-ID: 236848 [Multi-domain] Cd Length: 919 Bit Score: 76.04 E-value: 1.46e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 324 DTDKMTQVVDNILNNAIKYSpDGGKITVRMKT---TEDQMIL--SISDHGLGIPKQDLPRIFDRFYRVDRARSRAQGGTG 398
Cdd:PRK11107 405 DPLRLQQIITNLVGNAIKFT-ESGNIDILVELralSNTKVQLevQIRDTGIGISERQQSQLFQAFRQADASISRRHGGTG 483
|
90 100 110
....*....|....*....|....*....|....*.
gi 892137799 399 LGLSIAKEIIKQHKGFIWAKSEYGKGSTFTIVLPYD 434
Cdd:PRK11107 484 LGLVITQKLVNEMGGDISFHSQPNRGSTFWFHLPLD 519
|
|
| HATPase_Glnl-NtrB-like |
cd16918 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
328-432 |
4.77e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).
Pssm-ID: 340395 [Multi-domain] Cd Length: 109 Bit Score: 68.20 E-value: 4.77e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 328 MTQVVDNILNNAIKYSPD-GGKITVRMKTTEDQMI----------LSISDHGLGIPKQDLPRIFDRFYrvdrarSRAQGG 396
Cdd:cd16918 1 LIQVFLNLVRNAAQALAGsGGEIILRTRTQRQVTLghprhrlalrVSVIDNGPGIPPDLQDTIFYPMV------SGRENG 74
|
90 100 110
....*....|....*....|....*....|....*.
gi 892137799 397 TGLGLSIAKEIIKQHKGFIWAKSEYGKgSTFTIVLP 432
Cdd:cd16918 75 TGLGLAIAQNIVSQHGGVIECDSQPGH-TVFSVSLP 109
|
|
| HisKA |
pfam00512 |
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ... |
212-273 |
5.39e-14 |
|
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.
Pssm-ID: 459839 [Multi-domain] Cd Length: 66 Bit Score: 66.47 E-value: 5.39e-14
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 892137799 212 FVSNVSHELRTPLTSVKSYLEALDEGALCETVApDFIKVSLDETNRMMRMVTDLLHLSRIDN 273
Cdd:pfam00512 5 FLANLSHELRTPLTAIRGYLELLRDEKLDEEQR-EYLETILRSAERLLRLINDLLDLSRIEA 65
|
|
| PRK10815 |
PRK10815 |
two-component system sensor histidine kinase PhoQ; |
214-415 |
5.41e-14 |
|
two-component system sensor histidine kinase PhoQ;
Pssm-ID: 182754 [Multi-domain] Cd Length: 485 Bit Score: 73.90 E-value: 5.41e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 214 SNVSHELRTPLTSVKSYLEALDEGAL--CETVAPdfikVSLDETNRMMRMVTDLLHLSRIDNATSHLDVELINFTAFI-- 289
Cdd:PRK10815 271 TDLTHSLKTPLAVLQSTLRSLRSGKQmsVEQAEP----IMLEQISRISQQIGYYLHRASMRSEHNLLSRELHSVAPLLdn 346
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 290 -TFILNRFDKMKGqekekkYELVRDYPINSIWMEIDTDKMtQVVDNILNNAIKYSPDGGKITVRMktTEDQMILSISDHG 368
Cdd:PRK10815 347 lTSALNKVYQRKG------VNITLDISPEITFVGEKNDFM-EVMGNVLDNACKYCLEFVEISARQ--TDEHLHIVVEDDG 417
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 892137799 369 LGIP--KQDLprIFDRFYRVDRARSraqgGTGLGLSIAKEIIKQHKGFI 415
Cdd:PRK10815 418 PGIPesKREL--IFDRGQRADTLRP----GQGLGLSVAREITEQYEGKI 460
|
|
| HisKA |
cd00082 |
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ... |
212-270 |
1.15e-13 |
|
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.
Pssm-ID: 119399 [Multi-domain] Cd Length: 65 Bit Score: 65.70 E-value: 1.15e-13
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*....
gi 892137799 212 FVSNVSHELRTPLTSVKSYLEALDEGALCETVAPDFIKVSLDETNRMMRMVTDLLHLSR 270
Cdd:cd00082 7 FLANVSHELRTPLTAIRGALELLEEELLDDEEQREYLERIREEAERLLRLINDLLDLSR 65
|
|
| HATPase_PhoQ-like |
cd16954 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
305-431 |
1.47e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.
Pssm-ID: 340430 [Multi-domain] Cd Length: 135 Bit Score: 67.27 E-value: 1.47e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 305 EKKYELVRDYPINSIWMeIDTDKMTQVVDNILNNAIKYSpdGGKITVRMKTTEDQMILSISDHGLGIPKQDLPRIFDRFY 384
Cdd:cd16954 16 RKGVSISLDISPELRFP-GERNDLMELLGNLLDNACKWC--LEFVEVTARQTDGGLHLIVDDDGPGVPESQRSKIFQRGQ 92
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 892137799 385 RVDRARSraqgGTGLGLSIAKEIIKQHKGFIWAKSEYGKGSTFTIVL 431
Cdd:cd16954 93 RLDEQRP----GQGLGLAIAKEIVEQYGGELSLSDSPLGGARFEVVF 135
|
|
| HisKA |
smart00388 |
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ... |
212-273 |
6.22e-13 |
|
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.
Pssm-ID: 214644 [Multi-domain] Cd Length: 66 Bit Score: 63.35 E-value: 6.22e-13
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 892137799 212 FVSNVSHELRTPLTSVKSYLEALDEGALCETVApDFIKVSLDETNRMMRMVTDLLHLSRIDN 273
Cdd:smart00388 5 FLANLSHELRTPLTAIRGYLELLLDTELSEEQR-EYLETILREAERLLRLINDLLDLSRIEA 65
|
|
| HATPase_HupT_MifS-like |
cd16976 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
330-431 |
9.36e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.
Pssm-ID: 340435 [Multi-domain] Cd Length: 102 Bit Score: 64.02 E-value: 9.36e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 330 QVVDNILNNAIK--YSPDGGKITVRMKTTEDQMILSISDHGLGIPKQDLPRIFDRFYRvdrarSRAQG-GTGLGLSIAKE 406
Cdd:cd16976 3 QVLMNLLQNALDamGKVENPRIRIAARRLGGRLVLVVRDNGPGIAEEHLSRVFDPFFT-----TKPVGkGTGLGLSISYG 77
|
90 100
....*....|....*....|....*
gi 892137799 407 IIKQHKGFIWAKSEYGKGSTFTIVL 431
Cdd:cd16976 78 IVEEHGGRLSVANEEGAGARFTFDL 102
|
|
| HATPase_CckA-like |
cd16919 |
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ... |
334-432 |
9.64e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).
Pssm-ID: 340396 [Multi-domain] Cd Length: 116 Bit Score: 64.71 E-value: 9.64e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 334 NILNNAIKYSPDGGKITVRMKTTE---------------DQMILSISDHGLGIPKQDLPRIFDRFYRvdrarSRAQG-GT 397
Cdd:cd16919 7 NLAVNARDAMPEGGRLTIETSNQRvdadyalnyrdlipgNYVCLEVSDTGSGMPAEVLRRAFEPFFT-----TKEVGkGT 81
|
90 100 110
....*....|....*....|....*....|....*
gi 892137799 398 GLGLSIAKEIIKQHKGFIWAKSEYGKGSTFTIVLP 432
Cdd:cd16919 82 GLGLSMVYGFVKQSGGHLRIYSEPGVGTTVRIYLP 116
|
|
| HATPase_NtrY-like |
cd16944 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
324-432 |
1.49e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.
Pssm-ID: 340420 [Multi-domain] Cd Length: 108 Bit Score: 63.71 E-value: 1.49e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 324 DTDKMTQVVDNILNNA---IKYSPDG-GKITVRMKTTEDQMI-LSISDHGLGIPKQDLPRIFDRfYRVDRARsraqgGTG 398
Cdd:cd16944 1 DTTQISQVLTNILKNAaeaIEGRPSDvGEVRIRVEADQDGRIvLIVCDNGKGFPREMRHRATEP-YVTTRPK-----GTG 74
|
90 100 110
....*....|....*....|....*....|....
gi 892137799 399 LGLSIAKEIIKQHKGFIWAKSEYGKGSTFTIVLP 432
Cdd:cd16944 75 LGLAIVKKIMEEHGGRISLSNREAGGACIRIILP 108
|
|
| HATPase_DpiB-CitA-like |
cd16915 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
331-432 |
2.15e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.
Pssm-ID: 340392 [Multi-domain] Cd Length: 104 Bit Score: 63.08 E-value: 2.15e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 331 VVDNILNNAIKY---SPDGGK-ITVRMKTTEDQMILSISDHGLGIPKQDLPRIFDRFYRvdrarSRAQGGTGLGLSIAKE 406
Cdd:cd16915 4 IVGNLIDNALDAlaaTGAPNKqVEVFLRDEGDDLVIEVRDTGPGIAPELRDKVFERGVS-----TKGQGERGIGLALVRQ 78
|
90 100
....*....|....*....|....*.
gi 892137799 407 IIKQHKGFIWAKSEYGKGSTFTIVLP 432
Cdd:cd16915 79 SVERLGGSITVESEPGGGTTFSIRIP 104
|
|
| PRK13557 |
PRK13557 |
histidine kinase; Provisional |
216-438 |
1.55e-11 |
|
histidine kinase; Provisional
Pssm-ID: 237425 [Multi-domain] Cd Length: 540 Bit Score: 66.23 E-value: 1.55e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 216 VSHELRTPLTSVKSYLEALDEGALCETVAPDFIKVSLDE----TNRMMRMVTDLLHLSRidnaTSHLDVELINFTAFITF 291
Cdd:PRK13557 170 IAHDFNNLLQVMSGYLDVIQAALSHPDADRGRMARSVENiraaAERAATLTQQLLAFAR----KQRLEGRVLNLNGLVSG 245
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 292 ILNRFDKMKGQEKEKKYELVRDYPiNSiwmEIDTDKMTQVVDNILNNAIKYSPDGGKITVRMK----TTEDQMI------ 361
Cdd:PRK13557 246 MGELAERTLGDAVTIETDLAPDLW-NC---RIDPTQAEVALLNVLINARDAMPEGGRVTIRTRnveiEDEDLAMyhglpp 321
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 362 -----LSISDHGLGIPKQDLPRIFDRFYRvdrarSRAQG-GTGLGLSIAKEIIKQHKGFIWAKSEYGKGSTFTIVLPYDK 435
Cdd:PRK13557 322 gryvsIAVTDTGSGMPPEILARVMDPFFT-----TKEEGkGTGLGLSMVYGFAKQSGGAVRIYSEVGEGTTVRLYFPASD 396
|
...
gi 892137799 436 DAV 438
Cdd:PRK13557 397 QAE 399
|
|
| RocR |
COG3829 |
RocR-type transcriptional regulator, contains PAS, AAA-type ATPase, and DNA-binding Fis ... |
86-200 |
5.38e-10 |
|
RocR-type transcriptional regulator, contains PAS, AAA-type ATPase, and DNA-binding Fis domains [Transcription, Signal transduction mechanisms];
Pssm-ID: 443041 [Multi-domain] Cd Length: 448 Bit Score: 60.94 E-value: 5.38e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 86 QENLEQESKRLNSILFYMTDGVLATNRRGQIIMINDTAKKQLGLVKEDVLNRSILELLkieENYELRDLITQSPELLLDS 165
Cdd:COG3829 3 ELELKELEEELEAILDSLDDGIIVVDADGRITYVNRAAERILGLPREEVIGKNVTELI---PNSPLLEVLKTGKPVTGVI 79
|
90 100 110
....*....|....*....|....*....|....*
gi 892137799 166 QDINGEYLNLRVRFALIrRESGFISGLVAVLHDTT 200
Cdd:COG3829 80 QKTGGKGKTVIVTAIPI-FEDGEVIGAVETFRDIT 113
|
|
| PRK11086 |
PRK11086 |
sensory histidine kinase DcuS; Provisional |
331-436 |
9.92e-10 |
|
sensory histidine kinase DcuS; Provisional
Pssm-ID: 236839 [Multi-domain] Cd Length: 542 Bit Score: 60.31 E-value: 9.92e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 331 VVDNILNNAIKY--SPDGGKITVRMKTTEDQMILSISDHGLGIPKQDLPRIFDRFYrvdrarSRAQGGTGLGLSIAKEII 408
Cdd:PRK11086 437 ILGNLIENALEAvgGEEGGEISVSLHYRNGWLHCEVSDDGPGIAPDEIDAIFDKGY------STKGSNRGVGLYLVKQSV 510
|
90 100
....*....|....*....|....*...
gi 892137799 409 KQHKGFIWAKSEYGKGSTFTIVLPYDKD 436
Cdd:PRK11086 511 ENLGGSIAVESEPGVGTQFFVQIPWDGE 538
|
|
| PAS |
cd00130 |
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ... |
103-198 |
7.21e-09 |
|
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in signal transduction.
Pssm-ID: 238075 [Multi-domain] Cd Length: 103 Bit Score: 53.02 E-value: 7.21e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 103 MTDGVLATNRRGQIIMINDTAKKQLGLVKEDVLNRSILELLKIEENYELRDLITQSpELLLDSQDI-------NGEYLNL 175
Cdd:cd00130 1 LPDGVIVLDLDGRILYANPAAEQLLGYSPEELIGKSLLDLIHPEDREELRERLENL-LSGGEPVTLevrlrrkDGSVIWV 79
|
90 100
....*....|....*....|...
gi 892137799 176 RVRFALIRRESGFISGLVAVLHD 198
Cdd:cd00130 80 LVSLTPIRDEGGEVIGLLGVVRD 102
|
|
| YesM |
COG2972 |
Sensor histidine kinase YesM [Signal transduction mechanisms]; |
335-436 |
9.07e-09 |
|
Sensor histidine kinase YesM [Signal transduction mechanisms];
Pssm-ID: 442211 [Multi-domain] Cd Length: 445 Bit Score: 57.34 E-value: 9.07e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 335 ILNNAIKY----SPDGGKITVRMKTTEDQMILSISDHGLGIPKQDLPRIFDRFyrvdrarSRAQGGTGLGLSIAKEIIKQ 410
Cdd:COG2972 344 LVENAIEHgiepKEGGGTIRISIRKEGDRLVITVEDNGVGMPEEKLEKLLEEL-------SSKGEGRGIGLRNVRERLKL 416
|
90 100
....*....|....*....|....*....
gi 892137799 411 H---KGFIWAKSEYGKGSTFTIVLPYDKD 436
Cdd:COG2972 417 YygeEYGLEIESEPGEGTTVTIRIPLEEE 445
|
|
| PAS |
pfam00989 |
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined ... |
94-198 |
2.89e-08 |
|
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs. The PAS fold appears in archaea, eubacteria and eukarya. This domain can bind gases (O2, CO and NO), FAD, 4-hydroxycinnamic acid and NAD+ (Matilla et.al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 395786 [Multi-domain] Cd Length: 113 Bit Score: 51.65 E-value: 2.89e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 94 KRLNSILFYMTDGVLATNRRGQIIMINDTAKKQLGLVKEDVLNRSILELLKIEENYELRDLITQSPELLLDSQDI----- 168
Cdd:pfam00989 1 EDLRAILESLPDGIFVVDEDGRILYVNAAAEELLGLSREEVIGKSLLDLIPEEDDAEVAELLRQALLQGEESRGFevsfr 80
|
90 100 110
....*....|....*....|....*....|..
gi 892137799 169 --NGEYLNLRVRFALIRRESGFISGLVAVLHD 198
Cdd:pfam00989 81 vpDGRPRHVEVRASPVRDAGGEILGFLGVLRD 112
|
|
| PAS |
smart00091 |
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ... |
95-158 |
7.06e-08 |
|
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels.
Pssm-ID: 214512 Cd Length: 67 Bit Score: 49.32 E-value: 7.06e-08
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 892137799 95 RLNSILFYMTDGVLATNRRGQIIMINDTAKKQLGLVKEDVLNRSILELLKIEENYELRDLITQS 158
Cdd:smart00091 2 RLRAILESLPDGIFVLDLDGRILYANPAAEELLGYSPEELIGKSLLELIHPEDRERVQEALQRL 65
|
|
| PAS_9 |
pfam13426 |
PAS domain; This domain is found in many signalling proteins in which it functions as a sensor ... |
114-200 |
9.21e-08 |
|
PAS domain; This domain is found in many signalling proteins in which it functions as a sensor domain. It recognizes FMN, Zn(II), FAD and riboflavin (MAtilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 463873 [Multi-domain] Cd Length: 93 Bit Score: 49.77 E-value: 9.21e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 114 GQIIMINDTAKKQLGLVKEDVLNRSILELLKIEEN----YELRDLITQSPELLLDSQDINGEYLNLRVRFALIRRESGFI 189
Cdd:pfam13426 2 GRIIYVNDAALRLLGYTREELLGKSITDLFAEPEDserlREALREGKAVREFEVVLYRKDGEPFPVLVSLAPIRDDGGEL 81
|
90
....*....|.
gi 892137799 190 SGLVAVLHDTT 200
Cdd:pfam13426 82 VGIIAILRDIT 92
|
|
| PAS |
COG2202 |
PAS domain [Signal transduction mechanisms]; |
86-200 |
1.43e-07 |
|
PAS domain [Signal transduction mechanisms];
Pssm-ID: 441804 [Multi-domain] Cd Length: 258 Bit Score: 52.33 E-value: 1.43e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 86 QENLEQESKRLNSILFYMTDGVLATNRRGQIIMINDTAKKQLGLVKEDVLNRSILELLKIEENYELRDLITQspeLLLDS 165
Cdd:COG2202 3 EEALEESERRLRALVESSPDAIIITDLDGRILYVNPAFERLTGYSAEELLGKTLRDLLPPEDDDEFLELLRA---ALAGG 79
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 892137799 166 QDINGEYLNLR---------VRFALIRRESGFISGLVAVLHDTT 200
Cdd:COG2202 80 GVWRGELRNRRkdgslfwveLSISPVRDEDGEITGFVGIARDIT 123
|
|
| PAS |
COG2202 |
PAS domain [Signal transduction mechanisms]; |
59-200 |
2.37e-07 |
|
PAS domain [Signal transduction mechanisms];
Pssm-ID: 441804 [Multi-domain] Cd Length: 258 Bit Score: 51.95 E-value: 2.37e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 59 VLDMQGgsEITNITNNLNDLSEvIRLTQENLEQESKRLNSILFYMTDGVLATNRRGQIIMINDTAKKQLGLVKEDVLNRS 138
Cdd:COG2202 105 VRDEDG--EITGFVGIARDITE-RKRAEEALRESEERLRLLVENAPDGIFVLDLDGRILYVNPAAEELLGYSPEELLGKS 181
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 892137799 139 ILELLKIEENYELRDLI-------TQSPELLLDSQDINGEYLNLRVRFALIRRESGFIsGLVAVLHDTT 200
Cdd:COG2202 182 LLDLLHPEDRERLLELLrrlleggRESYELELRLKDGDGRWVWVEASAVPLRDGGEVI-GVLGIVRDIT 249
|
|
| RsbW |
COG2172 |
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; |
322-401 |
3.00e-06 |
|
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
Pssm-ID: 441775 [Multi-domain] Cd Length: 127 Bit Score: 46.44 E-value: 3.00e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 322 EIDTDKMTQVVDNILNNAIKYS---PDGGKITVRMKTTEDQMILSISDHGLGIPKQDLPrifdrfyrvDRARSRAQGGTG 398
Cdd:COG2172 29 EDDADDLVLAVSEAVTNAVRHAyggDPDGPVEVELELDPDGLEIEVRDEGPGFDPEDLP---------DPYSTLAEGGRG 99
|
...
gi 892137799 399 LGL 401
Cdd:COG2172 100 LFL 102
|
|
| ComP |
COG4585 |
Signal transduction histidine kinase ComP [Signal transduction mechanisms]; |
336-436 |
3.34e-06 |
|
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
Pssm-ID: 443642 [Multi-domain] Cd Length: 252 Bit Score: 48.08 E-value: 3.34e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 336 LNNAIKYSPdGGKITVRMKTTEDQMILSISDHGLGIPKQDLPrifdrfyrvdrarsraqgGTGLGLSIAKEIIKQHKGFI 415
Cdd:COG4585 171 LTNALKHAG-ATRVTVTLEVDDGELTLTVRDDGVGFDPEAAP------------------GGGLGLRGMRERAEALGGTL 231
|
90 100
....*....|....*....|.
gi 892137799 416 WAKSEYGKGSTFTIVLPYDKD 436
Cdd:COG4585 232 TIGSAPGGGTRVRATLPLAAA 252
|
|
| COG3920 |
COG3920 |
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ... |
335-437 |
7.26e-06 |
|
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];
Pssm-ID: 443125 [Multi-domain] Cd Length: 495 Bit Score: 48.36 E-value: 7.26e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 335 ILN----NAIKY---SPDGGKITVRMKTTEDQMILSISDHGLGIPKQdlprifdrfyrVDRARSRaqggtGLGLSIAKEI 407
Cdd:COG3920 403 ILNelvtNALKHaflSGEGGRIRVSWRREDGRLRLTVSDNGVGLPED-----------VDPPARK-----GLGLRLIRAL 466
|
90 100 110
....*....|....*....|....*....|
gi 892137799 408 IKQHKGFIwaKSEYGKGSTFTIVLPYDKDA 437
Cdd:COG3920 467 VRQLGGTL--ELDRPEGTRVRITFPLAELA 494
|
|
| COG4192 |
COG4192 |
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ... |
216-424 |
1.30e-05 |
|
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];
Pssm-ID: 443346 [Multi-domain] Cd Length: 640 Bit Score: 47.37 E-value: 1.30e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 216 VSHELRTPLTSVKSYLEALDEGALCE--TVAPDFIKVSLDETNRMMRMVTDLLHLSRIDNATshldVELINFTAFITfil 293
Cdd:COG4192 440 LAHELNQPLNAMSMYLFSAKKALEQEnyAQLPTSLDKIEGLIERMDKIIKSLRQFSRKSDTP----LQPVDLRQVIE--- 512
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 294 nrfDKMKGQEKEKKYELVRDYPINSIWMEIDTDKMTQVVDNILNNAIKYSPDGGKITVRMKTTEDQMILSISDHGLGIPk 373
Cdd:COG4192 513 ---QAWELVESRAKPQQITLHIPDDLMVQGDQVLLEQVLVNLLVNALDAVATQPQISVDLLSNAENLRVAISDNGNGWP- 588
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 892137799 374 qDLPRIFDRFYrvdrarSRAQGGTGLGLSIAKEIIKQHKGFIWAKSEYGKG 424
Cdd:COG4192 589 -LVDKLFTPFT------TTKEVGLGLGLSICRSIMQQFGGDLYLASTLERG 632
|
|
| HATPase_UhpB-NarQ-NarX-like |
cd16917 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
336-432 |
2.85e-05 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli UhpB, NarQ and NarX, and Bacillus subtilis YdfH, YhcY and YfiJ; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli UhpB, a HK of the UhpB-UhpA TCS, NarQ and NarX, HKs of the NarQ-NarP and NarX-NarL TCSs, respectively, and Bacillus YdfH, YhcY and YfiJ HKs, of the YdfH-YdfI, YhcY-YhcZ and YfiJ-YfiK TCSs, respectively. In addition, it includes Bacillus YxjM, ComP, LiaS and DesK, HKs of the YxjM-YxjML, ComP-ComA, LiaS-LiaR, DesR-DesK TCSs, respectively. Proteins having this HATPase domain have a histidine kinase dimerization and phosphoacceptor domain; some have accessory domains such as GAF, HAMP, PAS and MASE sensor domains.
Pssm-ID: 340394 [Multi-domain] Cd Length: 87 Bit Score: 42.54 E-value: 2.85e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 336 LNNAIKYSPdGGKITVRMKTTEDQMILSISDHGLGipkqdlprifdrFYRVDRArsraqGGTGLGLSIAKEIIKQHKGFI 415
Cdd:cd16917 9 LTNALKHAG-ASRVRVTLSYTADELTLTVVDDGVG------------FDGPAPP-----GGGGFGLLGMRERAELLGGTL 70
|
90
....*....|....*..
gi 892137799 416 WAKSEYGKGSTFTIVLP 432
Cdd:cd16917 71 TIGSRPGGGTRVTARLP 87
|
|
| dpiB |
PRK15053 |
sensor histidine kinase DpiB; Provisional |
105-432 |
3.00e-05 |
|
sensor histidine kinase DpiB; Provisional
Pssm-ID: 185013 [Multi-domain] Cd Length: 545 Bit Score: 46.36 E-value: 3.00e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 105 DGVLATNRRGQIIMINDTAKKQLGLVK--EDVLNRSILELLKIEENYelrdlITQSPElllDSQDI----NGeyLNLRVR 178
Cdd:PRK15053 233 EGLIAVDPHGYITAINRNARKMLGLSSpgRQWLGKPIAEVVRPADFF-----TEQIDE---KRQDVvanfNG--LSVIAN 302
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 179 FALIRRESGFISGLVAvlhdtteqekeererrlFVSNVS-HELRTPLTSVKSYLEALdegalcetvapdfiKVSLDETNR 257
Cdd:PRK15053 303 REAIRSGDDLLGAIIS-----------------FRSKDEiSTLNAQLTQIKQYVESL--------------RTLRHEHLN 351
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 258 MMRMVTDLLHLSRIDNATSHLDVELINFTAFITFILNRF-DKM----------KGQEKEKKYELVRDYPINSIWMEIDTD 326
Cdd:PRK15053 352 WMSTLNGLLQMKEYDRVLEMVQGESQAQQQLIDSLREAFaDRQvagllfgkvqRARELGLKMVIVPGSQLSQLPPGLDST 431
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 327 KMTQVVDNILNNAIKYS---PDGGK-ITVRMKTTEDQMILSISDHGLGIPKQDLPRIFDRFYrvdRARSRAQGGTGLGLS 402
Cdd:PRK15053 432 EFAAIVGNLLDNAFEASlrsDEGNKiVELFLSDEGDDVVIEVADQGCGVPESLRDKIFEQGV---STRADEPGEHGIGLY 508
|
330 340 350
....*....|....*....|....*....|
gi 892137799 403 IAKEIIKQHKGFIWAKSEYGKGSTFTIVLP 432
Cdd:PRK15053 509 LIASYVTRCGGVITLEDNDPCGTLFSIFIP 538
|
|
| PRK11388 |
PRK11388 |
DNA-binding transcriptional regulator DhaR; Provisional |
87-157 |
4.38e-05 |
|
DNA-binding transcriptional regulator DhaR; Provisional
Pssm-ID: 183114 [Multi-domain] Cd Length: 638 Bit Score: 45.82 E-value: 4.38e-05
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 892137799 87 ENLEQESKR----LNSILFYMTDGVLATNRRGQIIMINDTAKKQLGLVKEDVLNRSILELLKIEENyeLRDLITQ 157
Cdd:PRK11388 192 DSLLAESNRhlnqLNALLESMDDGVIAWDEQGNLQFLNAQAARLLRLDATASQGRAITELLTLPAV--LQQAIKQ 264
|
|
| sensory_box |
TIGR00229 |
PAS domain S-box; The PAS domain was previously described. This sensory box, or S-box domain ... |
94-200 |
9.67e-05 |
|
PAS domain S-box; The PAS domain was previously described. This sensory box, or S-box domain occupies the central portion of the PAS domain but is more widely distributed. It is often tandemly repeated. Known prosthetic groups bound in the S-box domain include heme in the oxygen sensor FixL, FAD in the redox potential sensor NifL, and a 4-hydroxycinnamyl chromophore in photoactive yellow protein. Proteins containing the domain often contain other regulatory domains such as response regulator or sensor histidine kinase domains. Other S-box proteins include phytochromes and the aryl hydrocarbon receptor nuclear translocator. [Regulatory functions, Small molecule interactions]
Pssm-ID: 272971 [Multi-domain] Cd Length: 124 Bit Score: 41.89 E-value: 9.67e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 94 KRLNSILFYMTDGVLATNRRGQIIMINDTAKKQLGLVKEDVLNRSILELL------KIEENYELRDLITQSP-ELLLDSQ 166
Cdd:TIGR00229 3 ERYRAIFESSPDAIIVIDLEGNILYVNPAFEEIFGYSAEELIGRNVLELIpeedreEVRERIERRLEGEPEPvSEERRVR 82
|
90 100 110
....*....|....*....|....*....|....
gi 892137799 167 DINGEYLNLRVRFALIRRESGFIsGLVAVLHDTT 200
Cdd:TIGR00229 83 RKDGSEIWVEVSVSPIRTNGGEL-GVVGIVRDIT 115
|
|
| TyrR |
COG3283 |
Transcriptional regulator TyrR of aromatic amino acids metabolism [Transcription, Amino acid ... |
90-144 |
1.29e-04 |
|
Transcriptional regulator TyrR of aromatic amino acids metabolism [Transcription, Amino acid transport and metabolism];
Pssm-ID: 442513 [Multi-domain] Cd Length: 514 Bit Score: 44.41 E-value: 1.29e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 892137799 90 EQESKRLNSILFYMTDGVLATNRRGQIIMINDTAKKQLGLVKEDVLNRSILELLK 144
Cdd:COG3283 76 EREHLELDALLEALPDPVFSIDLKGKIELANPAALSLLGLSEEELIGQPLSELLK 130
|
|
| HATPase_CheA-like |
cd16916 |
Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some ... |
347-432 |
6.69e-04 |
|
Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some hybrid sensor histidine kinases; This family includes the cytoplasmic histidine kinase (HK) CheA, a transmembrane receptor which, together with cytoplasmic adaptor protein (CheW), forms the lattice at the core of the chemosensory array that controls the cellular chemotaxis of motile bacteria and archaea. CheA forms a two-component signal transduction system (TCS) with the response regulator CheY. Proteins having this CheA-like HATPase domain generally also have a histidine-phosphotransfer domain, a histidine kinase homodimeric domain, and a regulatory domain; some are hybrid sensor histidine kinases as they contain a REC signal receiver domain.
Pssm-ID: 340393 [Multi-domain] Cd Length: 178 Bit Score: 40.64 E-value: 6.69e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 347 GKITVRMKTTEDQMILSISDHGLGIpkqDLPRIfdrfyrvdRARSRAQG------------------------------- 395
Cdd:cd16916 70 GTITLRAEHQGNQVVIEVSDDGRGI---DREKI--------REKAIERGlitadeaatlsddevlnlifapgfstaeqvt 138
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 892137799 396 ---GTGLGLSIAKEIIKQHKGFIWAKSEYGKGSTFTIVLP 432
Cdd:cd16916 139 dvsGRGVGMDVVKRSIESLGGTIEVESEPGQGTTFTIRLP 178
|
|
| PRK10618 |
PRK10618 |
phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional |
212-433 |
2.12e-03 |
|
phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional
Pssm-ID: 236726 [Multi-domain] Cd Length: 894 Bit Score: 40.69 E-value: 2.12e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 212 FVSNVSHELRTPLTSVKSYLEALDEGALCETVAPDfIKVSLDETNRMMRMVTDLLHLSRIDNATSHLDVELINFTAFITF 291
Cdd:PRK10618 453 FLQNIGDELKQPLQSLAQLAAQLRQTSDEEQQQPE-LDQLAEQSDVLVRLVDNIQLLNMLETQDWKPEQELFSLQDLIDE 531
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 292 IL-NRFDKMkgqeKEKKYELVRDYPINSIWMEI-DTDKMTQVVDNILNNAIKySPDGGKITVRMKTTE---DQMILSISD 366
Cdd:PRK10618 532 VLpEVLPAI----KRKGLQLLIHNHLKAEQLRIgDRDALRKILLLLLNYAIT-TTAYGKITLEVDQDEsspDRLTIRILD 606
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 892137799 367 HGLGIPKQDL---------PRIFDRFYRvdrarsraqgGTGLGLSIAKEIIKQHKGFIWAKSEYGKGSTFTIVLPY 433
Cdd:PRK10618 607 TGAGVSIKELdnlhfpflnQTQGDRYGK----------ASGLTFFLCNQLCRKLGGHLTIKSREGLGTRYSIHLKM 672
|
|
| HATPase_ETR2_ERS2-EIN4-like |
cd16938 |
Histidine kinase-like ATPase domain of Arabidopsis thaliana ETR2, ERS2, and EIN4, and related ... |
324-431 |
2.23e-03 |
|
Histidine kinase-like ATPase domain of Arabidopsis thaliana ETR2, ERS2, and EIN4, and related domains; This family includes the histidine kinase-like ATPase domains (HATPase) of three out of the five receptors that recognize the plant hormone ethylene in Arabidopsis thaliana. These three proteins have been classified as belonging to subfamily 2: ETR2, ERS2, and EIN4. They lack most of the motifs characteristic of histidine kinases, and EIN4 is the only one in this group containing the conserved histidine that is phosphorylated in two-component and phosphorelay systems. This family also includes the HATPase domains of Escherichia coli RcsD phosphotransferase which is a component of the Rcs-signaling system, a complex multistep phosphorelay involving five proteins, and is involved in many transcriptional networks such as cell division, biofilm formation, and virulence, among others. Also included is Schizosaccharomyces pombe Mak3 (Phk1) which participates in a multi-step two-component related system which regulates H2O2-induced activation of the Sty1 stress-activated protein kinase pathway. Most proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a GAF sensor domain; most are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340415 [Multi-domain] Cd Length: 133 Bit Score: 38.21 E-value: 2.23e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 324 DTDKMTQVVDNILNNAIKYSPDGGKITVRMKTTEDQMILSISDHGLGIPKQDLPRIFDRF-YRVDRARSRAQG------- 395
Cdd:cd16938 8 DERRVFQVLLHMLGNLLKMRNGGGNITFRVFLEGGSEDRSDRDWGPWRPSMSDESVEIRFeVEINDSGSPSIEsasmrns 87
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 892137799 396 ----------GTGLGLSIAKEIIKQHKGFIWAKSEYGKGSTFTIVL 431
Cdd:cd16938 88 lnrrynlselGEHLSFSICKQLVQLMGGNIWIVPGSGLGTTMSLLL 133
|
|
| CheA |
COG0643 |
Chemotaxis protein histidine kinase CheA [Signal transduction mechanisms]; |
347-432 |
2.84e-03 |
|
Chemotaxis protein histidine kinase CheA [Signal transduction mechanisms];
Pssm-ID: 440408 [Multi-domain] Cd Length: 563 Bit Score: 40.17 E-value: 2.84e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892137799 347 GKITVRMKTTEDQMILSISDHGLGIpkqDLPRIfdrfyrvdRARSRAQG------------------------------- 395
Cdd:COG0643 309 GTITLSAYHEGGRVVIEVSDDGRGL---DLEKI--------RAKAIEKGlitaeeaaalsdeellelifapgfstaeevt 377
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 892137799 396 ---GTGLGLSIAKEIIKQHKGFIWAKSEYGKGSTFTIVLP 432
Cdd:COG0643 378 dlsGRGVGMDVVKTNIEALGGTIEIESEPGKGTTFTLRLP 417
|
|
| |
