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Conserved domains on  [gi|893302591|emb|CNF01474|]
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methyl-accepting chemotaxis protein [Yersinia similis]

Protein Classification

methyl-accepting chemotaxis protein( domain architecture ID 1000955)

methyl-accepting chemotaxis protein (MCP) is a bacterial receptor that mediates chemotaxis to diverse signals, responding to changes in the concentration of attractants and repellents in the environment by altering swimming behavior

CATH:  1.10.287.950
Gene Ontology:  GO:0006935
PubMed:  18165013|20738376
SCOP:  4003862

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MCP_signal super family cl46910
Methyl-accepting chemotaxis protein (MCP), signaling domain; Methyl-accepting chemotaxis ...
 27-579 5.73e-143

Methyl-accepting chemotaxis protein (MCP), signaling domain; Methyl-accepting chemotaxis proteins (MCPs or chemotaxis receptors) are an integral part of the transmembrane protein complex that controls bacterial chemotaxis, together with the histidine kinase CheA, the receptor-coupling protein CheW, receptor-modification enzymes, and localized phosphatases. MCPs contain a four helix trans membrane region, an N-terminal periplasmic ligand binding domain, and a C-terminal HAMP domain followed by a cytoplasmic signaling domain. This C-terminal signaling domain dimerizes into a four-helix bundle and interacts with CheA through the adaptor protein CheW.


The actual alignment was detected with superfamily member PRK15048:

Pssm-ID: 481250 [Multi-domain]  Cd Length: 553  Bit Score: 424.80  E-value: 5.73e-143
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 893302591  27 INNMRLVTLFIVILAGILLLFAAAIGTSGYFLKQSNRSLAQATQEIDIRQGLSNSSNHLRTARLILiqAASSARIGDATG 106
Cdd:PRK15048   2 INRIRVVTLLVMVLGVFALLQLISGSLFFSSLHHSQKSFVVSNQLREQQGELTSTWDLMLQTRINL--SRSAVRMMMDSS 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 893302591 107 YQQG------LKNAEGRIAQSQQMFDLYYN---RPTKSETDIALDvplkKAYEQYRDdGMKPMLAATKEGHFEEVIsleA 177
Cdd:PRK15048  80 NQQSnakvelLDSARKTLAQAATHYKKFKSmapLPEMVATSRNID----EKYKNYYT-ALTELIDYLDYGNTGAYF---A 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 893302591 178 EKISQLDEGYNEPLLKAVKYRTEQANQINQSAQQEARLGYILMAGAFVLVILLTIIAFLLISKVIINPINWLVTRIQRIA 257
Cdd:PRK15048 152 QPTQGMQNAMGEAFAQYALSSEKLYRDIVTDNADDYRFAQWQLAVIALVVVLILLVAWYGIRRMLLTPLAKIIAHIREIA 231

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 893302591 258 QGDLTQAPVSFGHNEIGVLGSNIQQMQDSLAITVEAVRSSAESIYQGSREIALGNTDLSARTEQQAASLEQTAASMEQLT 337
Cdd:PRK15048 232 GGNLANTLTIDGRSEMGDLAQSVSHMQRSLTDTVTHVREGSDAIYAGTREIAAGNTDLSSRTEQQASALEETAASMEQLT 311

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 893302591 338 ATVKQNAENAHHASQLAANASGKAAQGGDIVSDVVSTMDKISLSSMKIAEITNVINSIAFQTNILALNAAVEAARAGEQG 417
Cdd:PRK15048 312 ATVKQNADNARQASQLAQSASDTAQHGGKVVDGVVKTMHEIADSSKKIADIISVIDGIAFQTNILALNAAVEAARAGEQG 391

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 893302591 418 RGFAVVASEVRNLAQRSADAAKEIESLIEASVDLIGDGSILVSDAGKTMNEIVTAVTHVTDIMGEIASASDEQSRGISQV 497
Cdd:PRK15048 392 RGFAVVAGEVRNLASRSAQAAKEIKALIEDSVSRVDTGSVLVESAGETMNNIVNAVTRVTDIMGEIASASDEQSRGIDQV 471

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 893302591 498 AQAVSEMDNVTQQNASLVQEASAAAASLEQQAEILTQAVAVFQLRGHPSIKEFKKPVSPPTGQNGSGINKKPTDDSLNWE 577
Cdd:PRK15048 472 ALAVSEMDRVTQQNASLVQESAAAAAALEEQASRLTQAVSAFRLAASPLTNKPQTPSRPASEQPPAQPRLRIAEQDPNWE 551


                 ..
gi 893302591 578 TF 579
Cdd:PRK15048 552 TF 553
 
Name Accession Description Interval E-value
PRK15048 PRK15048
methyl-accepting chemotaxis protein II; Provisional
 27-579 5.73e-143

methyl-accepting chemotaxis protein II; Provisional


Pssm-ID: 185008 [Multi-domain]  Cd Length: 553  Bit Score: 424.80  E-value: 5.73e-143
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 893302591  27 INNMRLVTLFIVILAGILLLFAAAIGTSGYFLKQSNRSLAQATQEIDIRQGLSNSSNHLRTARLILiqAASSARIGDATG 106
Cdd:PRK15048   2 INRIRVVTLLVMVLGVFALLQLISGSLFFSSLHHSQKSFVVSNQLREQQGELTSTWDLMLQTRINL--SRSAVRMMMDSS 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 893302591 107 YQQG------LKNAEGRIAQSQQMFDLYYN---RPTKSETDIALDvplkKAYEQYRDdGMKPMLAATKEGHFEEVIsleA 177
Cdd:PRK15048  80 NQQSnakvelLDSARKTLAQAATHYKKFKSmapLPEMVATSRNID----EKYKNYYT-ALTELIDYLDYGNTGAYF---A 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 893302591 178 EKISQLDEGYNEPLLKAVKYRTEQANQINQSAQQEARLGYILMAGAFVLVILLTIIAFLLISKVIINPINWLVTRIQRIA 257
Cdd:PRK15048 152 QPTQGMQNAMGEAFAQYALSSEKLYRDIVTDNADDYRFAQWQLAVIALVVVLILLVAWYGIRRMLLTPLAKIIAHIREIA 231

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 893302591 258 QGDLTQAPVSFGHNEIGVLGSNIQQMQDSLAITVEAVRSSAESIYQGSREIALGNTDLSARTEQQAASLEQTAASMEQLT 337
Cdd:PRK15048 232 GGNLANTLTIDGRSEMGDLAQSVSHMQRSLTDTVTHVREGSDAIYAGTREIAAGNTDLSSRTEQQASALEETAASMEQLT 311

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 893302591 338 ATVKQNAENAHHASQLAANASGKAAQGGDIVSDVVSTMDKISLSSMKIAEITNVINSIAFQTNILALNAAVEAARAGEQG 417
Cdd:PRK15048 312 ATVKQNADNARQASQLAQSASDTAQHGGKVVDGVVKTMHEIADSSKKIADIISVIDGIAFQTNILALNAAVEAARAGEQG 391

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 893302591 418 RGFAVVASEVRNLAQRSADAAKEIESLIEASVDLIGDGSILVSDAGKTMNEIVTAVTHVTDIMGEIASASDEQSRGISQV 497
Cdd:PRK15048 392 RGFAVVAGEVRNLASRSAQAAKEIKALIEDSVSRVDTGSVLVESAGETMNNIVNAVTRVTDIMGEIASASDEQSRGIDQV 471

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 893302591 498 AQAVSEMDNVTQQNASLVQEASAAAASLEQQAEILTQAVAVFQLRGHPSIKEFKKPVSPPTGQNGSGINKKPTDDSLNWE 577
Cdd:PRK15048 472 ALAVSEMDRVTQQNASLVQESAAAAAALEEQASRLTQAVSAFRLAASPLTNKPQTPSRPASEQPPAQPRLRIAEQDPNWE 551


                 ..
gi 893302591 578 TF 579
Cdd:PRK15048 552 TF 553
Tar COG0840
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];
37-541 9.81e-98

Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];


Pssm-ID: 440602 [Multi-domain]  Cd Length: 533  Bit Score: 307.72  E-value: 9.81e-98
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 893302591  37 IVILAGILLLFAAAIGTSGYFLKQSNRSLAQATQEIDIRQGLSNSSNHLRTARLILIQAASSARIGDATGYQQGLKNAEG 116
Cdd:COG0840    1 LLILLLLLALLLALLLLALSLLALLAAALLILLALLLAALTALALLLLLSLLALLLLLLLLALALLLVLLALLLLLALVV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 893302591 117 RIAQSQQMFDLYYNRPTKSETDIALDVPLKKAYEQYRDDGMKPMLAATKEGHFEEVISLEAEKISQLDEGYNEPLLKAVK 196
Cdd:COG0840   81 LLALLLALLLLLLALLALALAALALLAALAALLALLELLLAALLAALAIALLALAALLALAALALALLALALLAAAAAAA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 893302591 197 YRTEQANQINQSAQQEARLGYILMAGAFVLVILLTIIAFLLISKVIINPINWLVTRIQRIAQGDLTQAPVSFGHNEIGVL 276
Cdd:COG0840  161 AALAALLEAAALALAAAALALALLAAALLALVALAIILALLLSRSITRPLRELLEVLERIAEGDLTVRIDVDSKDEIGQL 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 893302591 277 GSNIQQMQDSLAITVEAVRSSAESIYQGSREIALGNTDLSARTEQQAASLEQTAASMEQLTATVKQNAENAHHASQLAAN 356
Cdd:COG0840  241 ADAFNRMIENLRELVGQVRESAEQVASASEELAASAEELAAGAEEQAASLEETAAAMEELSATVQEVAENAQQAAELAEE 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 893302591 357 ASGKAAQGGDIVSDVVS--------------TMDKISLSSMKIAEITNVINSIAFQTNILALNAAVEAARAGEQGRGFAV 422
Cdd:COG0840  321 ASELAEEGGEVVEEAVEgieeiresveetaeTIEELGESSQEIGEIVDVIDDIAEQTNLLALNAAIEAARAGEAGRGFAV 400

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 893302591 423 VASEVRNLAQRSADAAKEIESLIEASVD--------------LIGDGSILVSDAGKTMNEIVTAVTHVTDIMGEIASASD 488
Cdd:COG0840  401 VADEVRKLAERSAEATKEIEELIEEIQSeteeaveameegseEVEEGVELVEEAGEALEEIVEAVEEVSDLIQEIAAASE 480

                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|...
gi 893302591 489 EQSRGISQVAQAVSEMDNVTQQNASLVQEASAAAASLEQQAEILTQAVAVFQL 541
Cdd:COG0840  481 EQSAGTEEVNQAIEQIAAAAQENAASVEEVAAAAEELAELAEELQELVSRFKL 533
MA smart00283
Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Thought to undergo ...
 293-540 1.75e-72

Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Thought to undergo reversible methylation in response to attractants or repellants during bacterial chemotaxis.


Pssm-ID: 214599 [Multi-domain]  Cd Length: 262  Bit Score: 232.95  E-value: 1.75e-72
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 893302591   293 AVRSSAESIYQGSREIALGNTDLSARTEQQAASLEQTAASMEQLTATVKQNAENAHHASQLAANASGKAAQGGDIVSDVV 372
Cdd:smart00283   1 DVSEAVEEIAAGAEEQAEELEELAERMEELSASIEEVAANADEIAATAQSAAEAAEEGREAVEDAITAMDQIREVVEEAV 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 893302591   373 STMDKISLSSMKIAEITNVINSIAFQTNILALNAAVEAARAGEQGRGFAVVASEVRNLAQRSADAAKEIESLI------- 445
Cdd:smart00283  81 SAVEELEESSDEIGEIVSVIDDIADQTNLLALNAAIEAARAGEAGRGFAVVADEVRKLAERSAESAKEIESLIkeiqeet 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 893302591   446 -------EASVDLIGDGSILVSDAGKTMNEIVTAVTHVTDIMGEIASASDEQSRGISQVAQAVSEMDNVTQQNASLVQEA 518
Cdd:smart00283 161 neavaamEESSSEVEEGVELVEETGDALEEIVDSVEEIADLVQEIAAATDEQAAGSEEVNAAIDEIAQVTQETAAMSEEI 240

                          250       260
                   ....*....|....*....|..
gi 893302591   519 SAAAASLEQQAEILTQAVAVFQ 540
Cdd:smart00283 241 SAAAEELSGLAEELDELVERFK 262
MCP_signal cd11386
Methyl-accepting chemotaxis protein (MCP), signaling domain; Methyl-accepting chemotaxis ...
 320-517 1.15e-60

Methyl-accepting chemotaxis protein (MCP), signaling domain; Methyl-accepting chemotaxis proteins (MCPs or chemotaxis receptors) are an integral part of the transmembrane protein complex that controls bacterial chemotaxis, together with the histidine kinase CheA, the receptor-coupling protein CheW, receptor-modification enzymes, and localized phosphatases. MCPs contain a four helix trans membrane region, an N-terminal periplasmic ligand binding domain, and a C-terminal HAMP domain followed by a cytoplasmic signaling domain. This C-terminal signaling domain dimerizes into a four-helix bundle and interacts with CheA through the adaptor protein CheW.


Pssm-ID: 206779 [Multi-domain]  Cd Length: 200  Bit Score: 199.77  E-value: 1.15e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 893302591 320 EQQAASLEQTAASMEQLTATVKQNAENAHHASQLAANASGKAAQGGDIVSDVVSTMDKISLSSMKIAEITNVINSIAFQT 399
Cdd:cd11386    1 EELSASIEEVAASADQVAETSQQAAELAEKGREAAEDAINQMNQIDESVDEAVSAVEELEESSAEIGEIVEVIDDIAEQT 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 893302591 400 NILALNAAVEAARAGEQGRGFAVVASEVRNLAQRSADAAKEIESLIEASVDLIGDGSILVSDAGKTMNEIVTAVTHVTDI 479
Cdd:cd11386   81 NLLALNAAIEAARAGEAGRGFAVVADEVRKLAEESAEAAKEIEELIEEIQEQTEEAVEAMEETSEEVEEGVELVEETGRA 160

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 893302591 480 MGEIASASDEQSRGISQVAQAVSEMDNVTQQNASLVQE 517
Cdd:cd11386  161 FEEIVASVEEVADGIQEISAATQEQSASTQEIAAAVEE 198
MCPsignal pfam00015
Methyl-accepting chemotaxis protein (MCP) signalling domain; This domain is thought to ...
 351-508 1.99e-56

Methyl-accepting chemotaxis protein (MCP) signalling domain; This domain is thought to transduce the signal to CheA since it is highly conserved in very diverse MCPs.


Pssm-ID: 333767 [Multi-domain]  Cd Length: 172  Bit Score: 187.26  E-value: 1.99e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 893302591  351 SQLAANASGKAAQGGDIVSDVVSTMDKISLSSMKIAEITNVINSIAFQTNILALNAAVEAARAGEQGRGFAVVASEVRNL 430
Cdd:pfam00015   1 SDLAQLASEEAQDGGKEVANVVGQMEQIAQSSKKISDIISVIDEIAFQTNLLALNAAIEAARAGEQGRGFAVVADEVRKL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 893302591  431 AQRSADAAKEIESLIEASVDLIGD--------------GSILVSDAGKTMNEIVTAVTHVTDIMGEIASASDEQSRGISQ 496
Cdd:pfam00015  81 AERSAQAAKEIEALIIEIQKQTNDstasiestrqrvevGSTIVESTGEALKEIVDAVAEIADIVQEIAAASDEQSAGIDQ 160

                         170
                  ....*....|..
gi 893302591  497 VAQAVSEMDNVT 508
Cdd:pfam00015 161 VNQAVARMDQVT 172
 
Name Accession Description Interval E-value
PRK15048 PRK15048
methyl-accepting chemotaxis protein II; Provisional
 27-579 5.73e-143

methyl-accepting chemotaxis protein II; Provisional


Pssm-ID: 185008 [Multi-domain]  Cd Length: 553  Bit Score: 424.80  E-value: 5.73e-143
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 893302591  27 INNMRLVTLFIVILAGILLLFAAAIGTSGYFLKQSNRSLAQATQEIDIRQGLSNSSNHLRTARLILiqAASSARIGDATG 106
Cdd:PRK15048   2 INRIRVVTLLVMVLGVFALLQLISGSLFFSSLHHSQKSFVVSNQLREQQGELTSTWDLMLQTRINL--SRSAVRMMMDSS 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 893302591 107 YQQG------LKNAEGRIAQSQQMFDLYYN---RPTKSETDIALDvplkKAYEQYRDdGMKPMLAATKEGHFEEVIsleA 177
Cdd:PRK15048  80 NQQSnakvelLDSARKTLAQAATHYKKFKSmapLPEMVATSRNID----EKYKNYYT-ALTELIDYLDYGNTGAYF---A 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 893302591 178 EKISQLDEGYNEPLLKAVKYRTEQANQINQSAQQEARLGYILMAGAFVLVILLTIIAFLLISKVIINPINWLVTRIQRIA 257
Cdd:PRK15048 152 QPTQGMQNAMGEAFAQYALSSEKLYRDIVTDNADDYRFAQWQLAVIALVVVLILLVAWYGIRRMLLTPLAKIIAHIREIA 231

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 893302591 258 QGDLTQAPVSFGHNEIGVLGSNIQQMQDSLAITVEAVRSSAESIYQGSREIALGNTDLSARTEQQAASLEQTAASMEQLT 337
Cdd:PRK15048 232 GGNLANTLTIDGRSEMGDLAQSVSHMQRSLTDTVTHVREGSDAIYAGTREIAAGNTDLSSRTEQQASALEETAASMEQLT 311

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 893302591 338 ATVKQNAENAHHASQLAANASGKAAQGGDIVSDVVSTMDKISLSSMKIAEITNVINSIAFQTNILALNAAVEAARAGEQG 417
Cdd:PRK15048 312 ATVKQNADNARQASQLAQSASDTAQHGGKVVDGVVKTMHEIADSSKKIADIISVIDGIAFQTNILALNAAVEAARAGEQG 391

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 893302591 418 RGFAVVASEVRNLAQRSADAAKEIESLIEASVDLIGDGSILVSDAGKTMNEIVTAVTHVTDIMGEIASASDEQSRGISQV 497
Cdd:PRK15048 392 RGFAVVAGEVRNLASRSAQAAKEIKALIEDSVSRVDTGSVLVESAGETMNNIVNAVTRVTDIMGEIASASDEQSRGIDQV 471

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 893302591 498 AQAVSEMDNVTQQNASLVQEASAAAASLEQQAEILTQAVAVFQLRGHPSIKEFKKPVSPPTGQNGSGINKKPTDDSLNWE 577
Cdd:PRK15048 472 ALAVSEMDRVTQQNASLVQESAAAAAALEEQASRLTQAVSAFRLAASPLTNKPQTPSRPASEQPPAQPRLRIAEQDPNWE 551


                 ..
gi 893302591 578 TF 579
Cdd:PRK15048 552 TF 553
PRK15041 PRK15041
methyl-accepting chemotaxis protein;
27-579 4.08e-131

methyl-accepting chemotaxis protein;


Pssm-ID: 185001 [Multi-domain]  Cd Length: 554  Bit Score: 394.32  E-value: 4.08e-131
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 893302591  27 INNMRLVTLFIVILAGILLLFAAAIGTSGYFLKQSNRSLAqATQEIDIRQGLSNSS--------NHLRTARLILIQAASS 98
Cdd:PRK15041   2 LKRIKIVTSLLLVLAVFGLLQLTSGGLFFNALKNDKENFT-VLQTIRQQQSTLNGSwvallqtrNTLNRAGIRYMMDQNN 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 893302591  99 arIGDATGYQQGLKNAEGRIAQSQQMFDLYYNRPTKSETDIALDVPLKKAYEQYRD--DGMKPMLAATKEGHFeevisle 176
Cdd:PRK15041  81 --IGSGSTVAELMQSASISLKQAEKNWADYEALPRDPRQSTAAAAEIKRNYDIYHNalAELIQLLGAGKINEF------- 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 893302591 177 aekISQLDEGYNEPLLKAVKYRTEQANQINQSAQQEARLGY----ILMAGAFVLVILLTIIAFLLISKVIINPINWLVTR 252
Cdd:PRK15041 152 ---FDQPTQGYQDGFEKQYVAYMEQNDRLYDIAVSDNNASYsqamWILVGVMIVVLAVIFAVWFGIKASLVAPMNRLIDS 228

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 893302591 253 IQRIAQGDLTQAPVSFGHNEIGVLGSNIQQMQDSLAITVEAVRSSAESIYQGSREIALGNTDLSARTEQQAASLEQTAAS 332
Cdd:PRK15041 229 IRHIAGGDLVKPIEVDGSNEMGQLAESLRHMQGELMRTVGDVRNGANAIYSGASEIATGNNDLSSRTEQQAASLEETAAS 308

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 893302591 333 MEQLTATVKQNAENAHHASQLAANASGKAAQGGDIVSDVVSTMDKISLSSMKIAEITNVINSIAFQTNILALNAAVEAAR 412
Cdd:PRK15041 309 MEQLTATVKQNAENARQASHLALSASETAQRGGKVVDNVVQTMRDISTSSQKIADIISVIDGIAFQTNILALNAAVEAAR 388

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 893302591 413 AGEQGRGFAVVASEVRNLAQRSADAAKEIESLIEASVDLIGDGSILVSDAGKTMNEIVTAVTHVTDIMGEIASASDEQSR 492
Cdd:PRK15041 389 AGEQGRGFAVVAGEVRNLAQRSAQAAREIKSLIEDSVGKVDVGSTLVESAGETMAEIVSAVTRVTDIMGEIASASDEQSR 468

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 893302591 493 GISQVAQAVSEMDNVTQQNASLVQEASAAAASLEQQAEILTQAVAVFQL-------RGHPSIKEFKKPVSPPtgqngsgi 565
Cdd:PRK15041 469 GIDQVGLAVAEMDRVTQQNAALVEESAAAAAALEEQASRLTEAVAVFRIqqqqqqqRETSAVVKTVTPATPR-------- 540

                        570
                 ....*....|....
gi 893302591 566 NKKPTDDSLNWETF 579
Cdd:PRK15041 541 KMAVADSGENWETF 554
PRK09793 PRK09793
methyl-accepting chemotaxis protein IV;
27-544 5.94e-120

methyl-accepting chemotaxis protein IV;


Pssm-ID: 182079 [Multi-domain]  Cd Length: 533  Bit Score: 365.16  E-value: 5.94e-120
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 893302591  27 INNMRL-VTLF-IVILAGILLLfaAAIGTSGYFLKQSNRSLAQATQEIDIRQGLSNSSNHLRTARLILIQAAS-SARIGD 103
Cdd:PRK09793   2 FNRIRIsTTLFlILILCGILQI--GSNGMSFWAFRDDLQRLNQVEQSNQQRAALAQTRAVMLQASTALNKAGTlTALSYP 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 893302591 104 ATGYQQGLKNAEGRIAQSQQMFDLYYNRPTKSETDIALDVPLKKAYEQYRDDGMkpmlaatkeghfEEVISLEAEKISQL 183
Cdd:PRK09793  80 ADDIKTLMTTARASLTQSTTLFKSFMAMTAGNEHVRALQKETEKSFARWHNDLE------------HQATWLESNQLSDF 147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 893302591 184 ----DEGYNEPLLKAVKYRTEQANQINQSAQQEARLGY----ILMAGAFVLVILLTIIAFLLISKVIINPINWLVTRIQR 255
Cdd:PRK09793 148 ltapVQGSQNAFDVNFEAWQLEINHVLEAASAQSQRNYqisaLVFISMIIVAAIYISSALWWTRKMIVQPLAIIGSHFDS 227

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 893302591 256 IAQGDLTQAPVSFGHNEIGVLGSNIQQMQDSLAITVEAVRSSAESIYQGSREIALGNTDLSARTEQQAASLEQTAASMEQ 335
Cdd:PRK09793 228 IAAGNLARPIAVYGRNEITAIFASLKTMQQALRGTVSDVRKGSQEMHIGIAEIVAGNNDLSSRTEQQAASLAQTAASMEQ 307

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 893302591 336 LTATVKQNAENAHHASQLAANASGKAAQGGDIVSDVVSTMDKISLSSMKIAEITNVINSIAFQTNILALNAAVEAARAGE 415
Cdd:PRK09793 308 LTATVGQNADNARQASELAKNAATTAQAGGVQVSTMTHTMQEIATSSQKIGDIISVIDGIAFQTNILALNAAVEAARAGE 387

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 893302591 416 QGRGFAVVASEVRNLAQRSADAAKEIESLIEASVDLIGDGSILVSDAGKTMNEIVTAVTHVTDIMGEIASASDEQSRGIS 495
Cdd:PRK09793 388 QGRGFAVVAGEVRNLASRSAQAAKEIKGLIEESVNRVQQGSKLVNNAAATMTDIVSSVTRVNDIMGEIASASEEQRRGIE 467

                        490       500       510       520
                 ....*....|....*....|....*....|....*....|....*....
gi 893302591 496 QVAQAVSEMDNVTQQNASLVQEASAAAASLEQQAEILTQAVAVFQLRGH 544
Cdd:PRK09793 468 QVAQAVSQMDQVTQQNASLVEEAAVATEQLANQADHLSSRVAVFTLEEH 516
Tar COG0840
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];
37-541 9.81e-98

Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];


Pssm-ID: 440602 [Multi-domain]  Cd Length: 533  Bit Score: 307.72  E-value: 9.81e-98
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 893302591  37 IVILAGILLLFAAAIGTSGYFLKQSNRSLAQATQEIDIRQGLSNSSNHLRTARLILIQAASSARIGDATGYQQGLKNAEG 116
Cdd:COG0840    1 LLILLLLLALLLALLLLALSLLALLAAALLILLALLLAALTALALLLLLSLLALLLLLLLLALALLLVLLALLLLLALVV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 893302591 117 RIAQSQQMFDLYYNRPTKSETDIALDVPLKKAYEQYRDDGMKPMLAATKEGHFEEVISLEAEKISQLDEGYNEPLLKAVK 196
Cdd:COG0840   81 LLALLLALLLLLLALLALALAALALLAALAALLALLELLLAALLAALAIALLALAALLALAALALALLALALLAAAAAAA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 893302591 197 YRTEQANQINQSAQQEARLGYILMAGAFVLVILLTIIAFLLISKVIINPINWLVTRIQRIAQGDLTQAPVSFGHNEIGVL 276
Cdd:COG0840  161 AALAALLEAAALALAAAALALALLAAALLALVALAIILALLLSRSITRPLRELLEVLERIAEGDLTVRIDVDSKDEIGQL 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 893302591 277 GSNIQQMQDSLAITVEAVRSSAESIYQGSREIALGNTDLSARTEQQAASLEQTAASMEQLTATVKQNAENAHHASQLAAN 356
Cdd:COG0840  241 ADAFNRMIENLRELVGQVRESAEQVASASEELAASAEELAAGAEEQAASLEETAAAMEELSATVQEVAENAQQAAELAEE 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 893302591 357 ASGKAAQGGDIVSDVVS--------------TMDKISLSSMKIAEITNVINSIAFQTNILALNAAVEAARAGEQGRGFAV 422
Cdd:COG0840  321 ASELAEEGGEVVEEAVEgieeiresveetaeTIEELGESSQEIGEIVDVIDDIAEQTNLLALNAAIEAARAGEAGRGFAV 400

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 893302591 423 VASEVRNLAQRSADAAKEIESLIEASVD--------------LIGDGSILVSDAGKTMNEIVTAVTHVTDIMGEIASASD 488
Cdd:COG0840  401 VADEVRKLAERSAEATKEIEELIEEIQSeteeaveameegseEVEEGVELVEEAGEALEEIVEAVEEVSDLIQEIAAASE 480

                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|...
gi 893302591 489 EQSRGISQVAQAVSEMDNVTQQNASLVQEASAAAASLEQQAEILTQAVAVFQL 541
Cdd:COG0840  481 EQSAGTEEVNQAIEQIAAAAQENAASVEEVAAAAEELAELAEELQELVSRFKL 533
MA smart00283
Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Thought to undergo ...
 293-540 1.75e-72

Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Thought to undergo reversible methylation in response to attractants or repellants during bacterial chemotaxis.


Pssm-ID: 214599 [Multi-domain]  Cd Length: 262  Bit Score: 232.95  E-value: 1.75e-72
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 893302591   293 AVRSSAESIYQGSREIALGNTDLSARTEQQAASLEQTAASMEQLTATVKQNAENAHHASQLAANASGKAAQGGDIVSDVV 372
Cdd:smart00283   1 DVSEAVEEIAAGAEEQAEELEELAERMEELSASIEEVAANADEIAATAQSAAEAAEEGREAVEDAITAMDQIREVVEEAV 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 893302591   373 STMDKISLSSMKIAEITNVINSIAFQTNILALNAAVEAARAGEQGRGFAVVASEVRNLAQRSADAAKEIESLI------- 445
Cdd:smart00283  81 SAVEELEESSDEIGEIVSVIDDIADQTNLLALNAAIEAARAGEAGRGFAVVADEVRKLAERSAESAKEIESLIkeiqeet 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 893302591   446 -------EASVDLIGDGSILVSDAGKTMNEIVTAVTHVTDIMGEIASASDEQSRGISQVAQAVSEMDNVTQQNASLVQEA 518
Cdd:smart00283 161 neavaamEESSSEVEEGVELVEETGDALEEIVDSVEEIADLVQEIAAATDEQAAGSEEVNAAIDEIAQVTQETAAMSEEI 240

                          250       260
                   ....*....|....*....|..
gi 893302591   519 SAAAASLEQQAEILTQAVAVFQ 540
Cdd:smart00283 241 SAAAEELSGLAEELDELVERFK 262
MCP_signal cd11386
Methyl-accepting chemotaxis protein (MCP), signaling domain; Methyl-accepting chemotaxis ...
 320-517 1.15e-60

Methyl-accepting chemotaxis protein (MCP), signaling domain; Methyl-accepting chemotaxis proteins (MCPs or chemotaxis receptors) are an integral part of the transmembrane protein complex that controls bacterial chemotaxis, together with the histidine kinase CheA, the receptor-coupling protein CheW, receptor-modification enzymes, and localized phosphatases. MCPs contain a four helix trans membrane region, an N-terminal periplasmic ligand binding domain, and a C-terminal HAMP domain followed by a cytoplasmic signaling domain. This C-terminal signaling domain dimerizes into a four-helix bundle and interacts with CheA through the adaptor protein CheW.


Pssm-ID: 206779 [Multi-domain]  Cd Length: 200  Bit Score: 199.77  E-value: 1.15e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 893302591 320 EQQAASLEQTAASMEQLTATVKQNAENAHHASQLAANASGKAAQGGDIVSDVVSTMDKISLSSMKIAEITNVINSIAFQT 399
Cdd:cd11386    1 EELSASIEEVAASADQVAETSQQAAELAEKGREAAEDAINQMNQIDESVDEAVSAVEELEESSAEIGEIVEVIDDIAEQT 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 893302591 400 NILALNAAVEAARAGEQGRGFAVVASEVRNLAQRSADAAKEIESLIEASVDLIGDGSILVSDAGKTMNEIVTAVTHVTDI 479
Cdd:cd11386   81 NLLALNAAIEAARAGEAGRGFAVVADEVRKLAEESAEAAKEIEELIEEIQEQTEEAVEAMEETSEEVEEGVELVEETGRA 160

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 893302591 480 MGEIASASDEQSRGISQVAQAVSEMDNVTQQNASLVQE 517
Cdd:cd11386  161 FEEIVASVEEVADGIQEISAATQEQSASTQEIAAAVEE 198
MCPsignal pfam00015
Methyl-accepting chemotaxis protein (MCP) signalling domain; This domain is thought to ...
 351-508 1.99e-56

Methyl-accepting chemotaxis protein (MCP) signalling domain; This domain is thought to transduce the signal to CheA since it is highly conserved in very diverse MCPs.


Pssm-ID: 333767 [Multi-domain]  Cd Length: 172  Bit Score: 187.26  E-value: 1.99e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 893302591  351 SQLAANASGKAAQGGDIVSDVVSTMDKISLSSMKIAEITNVINSIAFQTNILALNAAVEAARAGEQGRGFAVVASEVRNL 430
Cdd:pfam00015   1 SDLAQLASEEAQDGGKEVANVVGQMEQIAQSSKKISDIISVIDEIAFQTNLLALNAAIEAARAGEQGRGFAVVADEVRKL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 893302591  431 AQRSADAAKEIESLIEASVDLIGD--------------GSILVSDAGKTMNEIVTAVTHVTDIMGEIASASDEQSRGISQ 496
Cdd:pfam00015  81 AERSAQAAKEIEALIIEIQKQTNDstasiestrqrvevGSTIVESTGEALKEIVDAVAEIADIVQEIAAASDEQSAGIDQ 160

                         170
                  ....*....|..
gi 893302591  497 VAQAVSEMDNVT 508
Cdd:pfam00015 161 VNQAVARMDQVT 172
TarH pfam02203
Tar ligand binding domain homolog; This entry represents the ligand-binding domain found in a ...
 52-202 8.09e-19

Tar ligand binding domain homolog; This entry represents the ligand-binding domain found in a number of methyl-accepting chemotaxis receptors, such as E.coli Tar (taxis to aspartate and repellents), which is a receptor for the attractant L-aspartate and also recognizes proteogenic amino acids, phthalic acid, Malic acid, 3,4-dihydroxymandelic acid, citrate, benzoate and derivatives, protocatechuate, vanillate, quinate, shikimate and dehydroshikimate (Matilla et al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 426656 [Multi-domain]  Cd Length: 152  Bit Score: 83.51  E-value: 8.09e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 893302591   52 GTSGYFLKQSNRSLAQA-TQEIDIRQGLSNSSNHLRTARLILIQAASSARIGDATGYQQGLKNAEGRIAQSQQMFDLYYN 130
Cdd:pfam02203   2 GLGLSGLSRSNDALREVyTNRLQQQAALADAWLLLLQARLTLNRAGIAALLPDAPDAAELLARARESLAQSDAAWKAYLA 81

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 893302591  131 RPTKSETDIALDVPLKKAYEQYRdDGMKPMLAATKEGHFEEVISLEAEKISQLDEGYNEPLLKAVKYRTEQA 202
Cdd:pfam02203  82 LPRTPDEEEALAAELKAKYDALQ-DGLAPLIAALRAGDLDAFFDQPTQKIQPLFEALYNAYLALRKFQNDAA 152
TarH smart00319
Homologues of the ligand binding domain of Tar; Homologues of the ligand binding domain of the ...
 62-196 1.74e-07

Homologues of the ligand binding domain of Tar; Homologues of the ligand binding domain of the wild-type bacterial aspartate receptor, Tar.


Pssm-ID: 128614 [Multi-domain]  Cd Length: 135  Bit Score: 50.54  E-value: 1.74e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 893302591    62 NRSLAQATQEIDIRQGLSNSSNHLRTARLILIQAASSARIGDAtgyqqgLKNAEGRIAQSQQMFDLYYNRPTKSETDIAL 141
Cdd:smart00319   1 ATSSYQQAALSLSRVLLLQARNNLNRAGIRMMQNNIGSKAKKL------MTAASESLKQAEKNYKSYENMTALPRADRAL 74

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 893302591   142 DVPLKKAYEQYRdDGMKPMLAATKEGHFEEVISLEAEKI-SQLDEGYNEPLLKAVK 196
Cdd:smart00319  75 DAELKEKFQQYI-TALQELIQILGNGNLGAFFDQPTQGMqDGFDPAYRDWLQQAVA 129
HAMP pfam00672
HAMP domain;
237-287 1.70e-06

HAMP domain;


Pssm-ID: 459898 [Multi-domain]  Cd Length: 53  Bit Score: 45.31  E-value: 1.70e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 893302591  237 LISKVIINPINWLVTRIQRIAQGDLTQAPVSFGHNEIGVLGSNIQQMQDSL 287
Cdd:pfam00672   1 LLARRILRPLRRLAEAARRIASGDLDVRLPVSGRDEIGELARAFNQMAERL 51
HAMP cd06225
Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; ...
 243-287 2.47e-06

Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The structure of the Af1503 HAMP dimer from Archaeoglobus fulgidus has been solved using nuclear magnetic resonance, revealing a parallel four-helix bundle; this structure has been confirmed by cross-linking analysis of HAMP domains from the Escherichia coli aerotaxis receptor Aer. It has been suggested that the four-helix arrangement can rotate between the unusually packed conformation observed in the NMR structure and a canonical coiled-coil arrangement. Such rotation may coincide with signal transduction, but a common mechanism by which HAMP domains relay a variety of input signals has yet to be established.


Pssm-ID: 381743 [Multi-domain]  Cd Length: 45  Bit Score: 44.36  E-value: 2.47e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 893302591 243 INPINWLVTRIQRIAQGDLTQ-APVSfGHNEIGVLGSNIQQMQDSL 287
Cdd:cd06225    1 TRPLRRLTEAARRIAEGDLDVrVPVR-SKDEIGELARAFNQMAERL 45
YesM COG2972
Sensor histidine kinase YesM [Signal transduction mechanisms];
211-287 3.68e-06

Sensor histidine kinase YesM [Signal transduction mechanisms];


Pssm-ID: 442211 [Multi-domain]  Cd Length: 445  Bit Score: 49.63  E-value: 3.68e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 893302591 211 QEARLGYILMAGAFVLVILLTIIAFLLISKVIINPINWLVTRIQRIAQGDLTQAPVSfGHNEIGVLGSNIQQMQDSL 287
Cdd:COG2972  150 RGLFSLRRLILLIILLLLLLALLLSYLLSRSITRPIKRLKKAMKKVEKGDLVRLEVS-GNDEIGILARSFNEMVERI 225
NarQ COG3850
Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction ...
 219-547 4.31e-06

Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction mechanisms];


Pssm-ID: 443059 [Multi-domain]  Cd Length: 448  Bit Score: 49.50  E-value: 4.31e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 893302591 219 LMAGAFVLVILLTIIAFLLISKVIINPINWLVTRIQRIAQGDLTQAPVSFGHNEIGVLGSNIQQMQDSLAITVEAVRSSA 298
Cdd:COG3850  119 LALLRLLLALLLALLLAYLLRRRIVRPLRRLTQAAERIARGDFDARVPVSGRDELGTLARAFNRMADELQELYAELEEEE 198

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 893302591 299 ESIYQGSREIALGNTDLSARTEQQAASLEQTAASMEQLTATVKQNAENAHHASQLAANASGKAAQGGDIVSDVVSTMDKI 378
Cdd:COG3850  199 ELEAELELLALLDELLLLAALLLLLALLLALLLAALLAALLLLLLLQDALAESELLALNILAGLLELLLALLLLLLASAL 278

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 893302591 379 SLSSMKIAEITNVINSIAFQTNILALNAAVEAARAGEQGRGFAVVASEVRNLAQRSADAAKEIESLIEASVDLIGDGSIL 458
Cdd:COG3850  279 LLLELELLALLLELVELLALAAAEEALLLLVELAALLLLLLLQAIANASLLLIALASVVAALLELASILALQAALEAAAA 358

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 893302591 459 VSDAGKTMNEIVTAVTHVTDIMGEIASASDEQSRGISQVAQAVSEMDNVTQQNASLVQEASAAAASLEQQAEILTQAVAV 538
Cdd:COG3850  359 GAALAAAAAAAGLARALAQAGADAAEALGLLAEASEGAAGQGAGLVDVEGGVAGEGGLVVLIVSIIAGGEAIARGEALAA 438


                 ....*....
gi 893302591 539 FQLRGHPSI 547
Cdd:COG3850  439 RGLAAAAAL 447
NtrY COG5000
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ...
 217-288 5.19e-06

Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];


Pssm-ID: 444024 [Multi-domain]  Cd Length: 422  Bit Score: 49.19  E-value: 5.19e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 893302591 217 YILMAGAFVLVILLTIIAFLLISKVIINPINWLVTRIQRIAQGDLTQAPVSFGHNEIGVLGSNIQQMQDSLA 288
Cdd:COG5000    8 LLLLLLIALLLLLLALWLALLLARRLTRPLRRLAEATRAVAAGDLSVRLPVTGDDEIGELARAFNRMTDQLK 79
COG4192 COG4192
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ...
 160-378 8.17e-06

Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];


Pssm-ID: 443346 [Multi-domain]  Cd Length: 640  Bit Score: 48.91  E-value: 8.17e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 893302591 160 MLAATKEGhfEEVISLEAEKISQLDEGYNEPLLKAvkyrTEQANQINQSAQQEARLGYILMAGAFVLVILLTI-IAFLLI 238
Cdd:COG4192  274 ELAAQATL--EALAEENNSILEQLRTQISGLVGNS----REQLVALNQETAQLVQQSGILLLAIALLSLLLAVlINYFYV 347

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 893302591 239 SKVIINPINWLVTRIQRIAQGDLTQAPVSFGHNEIGVLGSNIQQMQDSLaitVEAVRSSAESIyqgSREIALGNTDLSAR 318
Cdd:COG4192  348 RRRLVKRLNALSDAMAAIAAGDLDVPIPVDGNDEIGRIARLLRVFRDQA---IEKTQELETEI---EERKRIEKNLRQTQ 421

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 893302591 319 TE-QQAASLEQTAASMEQLTATVKQ--NAENAHHASQLAANASGKAAQGG---DIVSDVVSTMDKI 378
Cdd:COG4192  422 DElIQAAKMAVVGQTMTSLAHELNQplNAMSMYLFSAKKALEQENYAQLPtslDKIEGLIERMDKI 487
HAMP COG2770
HAMP domain [Signal transduction mechanisms];
19-542 2.53e-05

HAMP domain [Signal transduction mechanisms];


Pssm-ID: 442051 [Multi-domain]  Cd Length: 631  Bit Score: 47.03  E-value: 2.53e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 893302591  19 YKDTKVSFINNMRLVTLFIVILAGILLLFAAAIGTSGYFLKQSNRSLAQATQEIDIRQGLSNSSNHLRTARLILIQAASS 98
Cdd:COG2770   13 LLLLLLLLLAGALLVLALISLRLLLALLLLLLLLLALLLLLLLLLLLLLAALVLLALLLAAALLLLLLLLSLVALAALLL 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 893302591  99 ARIGDATGYQQGLKNAEGRIAQSQQMFDLYYNRPTKSETDIALDVPLKKAYEQYRDDGMKPMLAATKEGHFEEVISLEAE 178
Cdd:COG2770   93 ALLLLLLLALLLLLAALLLLLLLAALALLLLLLLLLAALLALLLALALLALLLGLAAARLLLAALLALAAALALALGAGE 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 893302591 179 KISQLDEGYNEPLLKAVKYRTEQANQINQSAQQEARLGYILMAGAFVLVILLTIIAFLLISKVIINPINWLVTRIQRIAQ 258
Cdd:COG2770  173 LLLLADLAAAIAALLAALLLLLLGGLLLVVLLEAALAALLLLLLLALLALLLALLLALLLARRITRPLRRLAEAARRIAA 252

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 893302591 259 GDLTQAPVSFGHNEIGVLGSNIQQMQDSLAITVEAVRSSAESIYQGSREIALGNTDLSARTEQQAASLEQTAASMEQLTA 338
Cdd:COG2770  253 GDLDVRIPVSRKDEIGELARAFNRMADSLRESIEEAEEEEELAEAELARLLEALLELLLALLLLLLALLLLAAAALLLEL 332

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 893302591 339 TVKQNAENAHHASQLAANASGKAAQGGDIVSDVVSTMDKISLSSMKIAEITNVINSIAFQTNILALNAAVEAARAGEQGR 418
Cdd:COG2770  333 LLLLLLALLLLLLLAADLLLALALAALLLLLALELLLEAELLVLLALEALALEAELAAVLALLAALAAALLLLELALEEL 412

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 893302591 419 GFAVVASEVRNLAQRSADAAKEIESLIEASVDLIGDGSILVSDAGKTMNEIVTAVTHVTDIMGEIASASDEQSRGISQVA 498
Cdd:COG2770  413 VLALLALALLALAAAAAAAEAAAAALELAAAAIAAAAAAEAEGGLAELEAEELVAAAEALLLLAALLLLAALGALELLLL 492

                        490       500       510       520
                 ....*....|....*....|....*....|....*....|....
gi 893302591 499 QAVSEMDNVTQQNASLVQEASAAAASLEQQAEILTQAVAVFQLR 542
Cdd:COG2770  493 EEEEEAGAAAEELAEELLLLEGLLLLLLLEAEALEVAEELLELE 536
HAMP smart00304
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain;
242-292 8.32e-05

HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain;


Pssm-ID: 197640 [Multi-domain]  Cd Length: 53  Bit Score: 40.31  E-value: 8.32e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 893302591   242 IINPINWLVTRIQRIAQGDLTQAPVSFGHNEIGVLGSNIQQMQDSLAITVE 292
Cdd:smart00304   3 LLRPLRRLAEAAQRIADGDLTVRLPVDGRDEIGELARAFNEMADRLEETIA 53
PRK10600 PRK10600
nitrate/nitrite two-component system sensor histidine kinase NarX;
147-328 8.22e-04

nitrate/nitrite two-component system sensor histidine kinase NarX;


Pssm-ID: 182581 [Multi-domain]  Cd Length: 569  Bit Score: 42.35  E-value: 8.22e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 893302591 147 KAYEQYRDDGMKPMLAATKegHFEEVISLEAEKISQLDEgynepLLKAVKYRTEQanqinqsaqqeaRLGYILM--AGAF 224
Cdd:PRK10600  71 QALQDYWRNELKPALQQAQ--NPEDVAADVAQFVAGLDA-----LVSAFDHTTEM------------RIETVVLvhRVFA 131

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 893302591 225 VLVILLTIIAFLLISKVIINPINWLVTRIQRIAQGDLTQAPVSFGHNEIGVLGSNIQQMQDSLAitveavrssaeSIYQg 304
Cdd:PRK10600 132 VFMALLLVFTIIWLRRRLLQPWRQLLSMANAVSHRDFTQRANISGRDEMAMLGTALNNMSAELA-----------ESYA- 199

                        170       180
                 ....*....|....*....|....
gi 893302591 305 sreialgntDLSARTEQQAASLEQ 328
Cdd:PRK10600 200 ---------VLEQRVQEKTAGLEQ 214
Tar_Tsr_sensor cd19407
ligand binding sensor domain of Tar- and Tsr-related chemoreceptors; Escherichia coli Tar ...
 70-165 4.89e-03

ligand binding sensor domain of Tar- and Tsr-related chemoreceptors; Escherichia coli Tar (taxis to aspartate and repellents) and Tsr (taxis to serine and repellents) are homologous transmembrane chemoreceptors that have a high specificity for aspartate and serine, respectively. Both are homodimeric receptors and contain an N-terminal periplasmic ligand binding domain, a transmembrane region, a HAMP domain and a C-terminal cytosolic signaling domain. E. coli Tar mediates bacterial chemotaxis toward attractants, including aspartate (Asp) and maltose, and away from repellents such as nickel and cobalt ions. Tsr has many roles, including sensing of external (serine, leucine) and internal (pH) environments. In Salmonella enterica serovar Typhimurium, Tsr, also called methyl-accepting chemotaxis protein (MCP), is involved in sensing host-derived nitrate in murine intestinal epithelium, thus contributing to invasion of Peyer's patches. This model represents the ligand binding domain of Tar and Tsr.


Pssm-ID: 438625 [Multi-domain]  Cd Length: 131  Bit Score: 37.69  E-value: 4.89e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 893302591  70 QEIDIRQGLSNSSNHLRTARLILIQAASSARIGDATGYQQG----LKNAEGRIAQSQQMFDLYYNRPTKSETDIALDVPL 145
Cdd:cd19407    2 QLRQQQSALNDSWVALLQARNTLNRAAIRYLLDANNGGGAAvaelLDQAKKSLAQAEKHFAQFKALPKLPGQDEALAAEL 81

                         90       100
                 ....*....|....*....|
gi 893302591 146 KKAYEQYRDDGMKPMLAATK 165
Cdd:cd19407   82 EQSYQAYHDALAELIQFLEA 101
MA smart00283
Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Thought to undergo ...
 290-369 5.70e-03

Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Thought to undergo reversible methylation in response to attractants or repellants during bacterial chemotaxis.


Pssm-ID: 214599 [Multi-domain]  Cd Length: 262  Bit Score: 38.81  E-value: 5.70e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 893302591   290 TVEAVRSSAESIYQGSREIALGNTDLSARTEQQAASLEQTAASMEQLTATVKQNAENAHHASQLAANASGKAAQGGDIVS 369
Cdd:smart00283 180 LVEETGDALEEIVDSVEEIADLVQEIAAATDEQAAGSEEVNAAIDEIAQVTQETAAMSEEISAAAEELSGLAEELDELVE 259
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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