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Conserved domains on  [gi|907114016|emb|CTE11247|]
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Tranposase (orf2) [Streptococcus pneumoniae]

Protein Classification

transposase( domain architecture ID 1750052)

transposase binds to the end of a transposon and catalyzes the movement of the transposon to another part of the genome by a cut and paste mechanism or a replicative transposition mechanism

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
transpos_IS5_4 super family cl41333
IS5 family transposase;
1-99 5.95e-26

IS5 family transposase;


The actual alignment was detected with superfamily member NF033581:

Pssm-ID: 468098 [Multi-domain]  Cd Length: 284  Bit Score: 97.39  E-value: 5.95e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 907114016   1 MKLFKMS-CRNIRQVGKILA---DSGYQGLMKICPQAQTSRKSSKLKPLTAEDKAYNHALSKERSKVENIFAKVKTFKMF 76
Cdd:NF033581 180 SRAAKELlHGDEKTVYADKGydgDEGYQGLREAGVKPHIPRKKSRNRPLTEAQKRRNRLKSKIRARVEHVFGVLKRFFGL 259

                         90       100
                 ....*....|....*....|...
gi 907114016  77 STTYRNHRKRFGLRMNLIAGIIN 99
Cdd:NF033581 260 SKVRYRGLKRVGARFNLIAALYN 282
 
Name Accession Description Interval E-value
transpos_IS5_4 NF033581
IS5 family transposase;
1-99 5.95e-26

IS5 family transposase;


Pssm-ID: 468098 [Multi-domain]  Cd Length: 284  Bit Score: 97.39  E-value: 5.95e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 907114016   1 MKLFKMS-CRNIRQVGKILA---DSGYQGLMKICPQAQTSRKSSKLKPLTAEDKAYNHALSKERSKVENIFAKVKTFKMF 76
Cdd:NF033581 180 SRAAKELlHGDEKTVYADKGydgDEGYQGLREAGVKPHIPRKKSRNRPLTEAQKRRNRLKSKIRARVEHVFGVLKRFFGL 259

                         90       100
                 ....*....|....*....|...
gi 907114016  77 STTYRNHRKRFGLRMNLIAGIIN 99
Cdd:NF033581 260 SKVRYRGLKRVGARFNLIAALYN 282
IS5 COG3039
Transposase and inactivated derivatives, IS5 family [Mobilome: prophages, transposons];
17-71 2.28e-08

Transposase and inactivated derivatives, IS5 family [Mobilome: prophages, transposons];


Pssm-ID: 442273 [Multi-domain]  Cd Length: 316  Bit Score: 49.87  E-value: 2.28e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 907114016  17 ILADSGYQG------LMKICPQAQTSRKSSKLKPLTAEDKAYNHALSKERSKVENIFAKVK 71
Cdd:COG3039  217 VYADKGYQGaekreeLKARGIRWHIARKPGRNKPLSELQKRRNRRKAKVRAKVEHPFGVIK 277
DDE_Tnp_4 pfam13359
DDE superfamily endonuclease; This family of proteins are related to pfam00665 and are ...
 16-87 1.53e-05

DDE superfamily endonuclease; This family of proteins are related to pfam00665 and are probably endonucleases of the DDE superfamily. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis. The catalytic activity of this enzyme involves DNA cleavage at a specific site followed by a strand transfer reaction.


Pssm-ID: 463855 [Multi-domain]  Cd Length: 158  Bit Score: 41.11  E-value: 1.53e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 907114016   16 KILADSGYQGLMKICpqaqTSRKSSKLKPLTAEDKAYNHALSKERSKVENIFAKVK-TFKMFSTTYRNHRKRF 87
Cdd:pfam13359  77 YILADKGFPISDWLL----VPYKKPGGAQLSPEEVEFNRRIASARIHVERVIGRLKgRFRILRGRLPISLPER 145
 
Name Accession Description Interval E-value
transpos_IS5_4 NF033581
IS5 family transposase;
1-99 5.95e-26

IS5 family transposase;


Pssm-ID: 468098 [Multi-domain]  Cd Length: 284  Bit Score: 97.39  E-value: 5.95e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 907114016   1 MKLFKMS-CRNIRQVGKILA---DSGYQGLMKICPQAQTSRKSSKLKPLTAEDKAYNHALSKERSKVENIFAKVKTFKMF 76
Cdd:NF033581 180 SRAAKELlHGDEKTVYADKGydgDEGYQGLREAGVKPHIPRKKSRNRPLTEAQKRRNRLKSKIRARVEHVFGVLKRFFGL 259

                         90       100
                 ....*....|....*....|...
gi 907114016  77 STTYRNHRKRFGLRMNLIAGIIN 99
Cdd:NF033581 260 SKVRYRGLKRVGARFNLIAALYN 282
IS5 COG3039
Transposase and inactivated derivatives, IS5 family [Mobilome: prophages, transposons];
17-71 2.28e-08

Transposase and inactivated derivatives, IS5 family [Mobilome: prophages, transposons];


Pssm-ID: 442273 [Multi-domain]  Cd Length: 316  Bit Score: 49.87  E-value: 2.28e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 907114016  17 ILADSGYQG------LMKICPQAQTSRKSSKLKPLTAEDKAYNHALSKERSKVENIFAKVK 71
Cdd:COG3039  217 VYADKGYQGaekreeLKARGIRWHIARKPGRNKPLSELQKRRNRRKAKVRAKVEHPFGVIK 277
DDE_Tnp_4 pfam13359
DDE superfamily endonuclease; This family of proteins are related to pfam00665 and are ...
 16-87 1.53e-05

DDE superfamily endonuclease; This family of proteins are related to pfam00665 and are probably endonucleases of the DDE superfamily. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis. The catalytic activity of this enzyme involves DNA cleavage at a specific site followed by a strand transfer reaction.


Pssm-ID: 463855 [Multi-domain]  Cd Length: 158  Bit Score: 41.11  E-value: 1.53e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 907114016   16 KILADSGYQGLMKICpqaqTSRKSSKLKPLTAEDKAYNHALSKERSKVENIFAKVK-TFKMFSTTYRNHRKRF 87
Cdd:pfam13359  77 YILADKGFPISDWLL----VPYKKPGGAQLSPEEVEFNRRIASARIHVERVIGRLKgRFRILRGRLPISLPER 145
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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