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Conserved domains on  [gi|919009075|emb|CTQ86751|]
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G protein-coupled receptor [Caenorhabditis elegans]

Protein Classification

serpentine receptor( domain architecture ID 366230)

serpentine receptor, also known as seven TM receptor (Str), belongs to a family of seven-transmembrane (7TM) G protein-coupled receptors involved in chemoreception, a central sense of soil nematodes like Caenorhabditis elegans

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
7TM_GPCR_Srd super family cl22924
Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis ...
 2-135 3.42e-32

Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srd is part of the larger Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


The actual alignment was detected with superfamily member pfam10326:

Pssm-ID: 419896  Cd Length: 307  Bit Score: 116.02  E-value: 3.42e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919009075    2 FAAGQYWIFGANGEKIWCLRDCFATLGLVGLMGICCFVIIFCGLKTFRKMIEVQGSMSKQTAALNKQLFLTLTLQTLLPF 81
Cdd:pfam10326 174 YVGPVYYPTDENGSKVIRWRSLIGLLIMTFIIGISFSIIIYCGIKMYFKMKKLKSLGSEKTRKLQKQLFKALVIQTLIPT 253

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 919009075   82 ILMYGPVGLIFFAPLFEWNLQLFVSSAGATTAIYPAFEPLIVIFCISLFRNAVF 135
Cdd:pfam10326 254 ILMYIPVGILFLLPLFNIEIGFLSGIITATIALYPAIDPLPAMFIIKEYRNAIK 307
 
Name Accession Description Interval E-value
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
 2-135 3.42e-32

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402099  Cd Length: 307  Bit Score: 116.02  E-value: 3.42e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919009075    2 FAAGQYWIFGANGEKIWCLRDCFATLGLVGLMGICCFVIIFCGLKTFRKMIEVQGSMSKQTAALNKQLFLTLTLQTLLPF 81
Cdd:pfam10326 174 YVGPVYYPTDENGSKVIRWRSLIGLLIMTFIIGISFSIIIYCGIKMYFKMKKLKSLGSEKTRKLQKQLFKALVIQTLIPT 253

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 919009075   82 ILMYGPVGLIFFAPLFEWNLQLFVSSAGATTAIYPAFEPLIVIFCISLFRNAVF 135
Cdd:pfam10326 254 ILMYIPVGILFLLPLFNIEIGFLSGIITATIALYPAIDPLPAMFIIKEYRNAIK 307
 
Name Accession Description Interval E-value
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
 2-135 3.42e-32

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402099  Cd Length: 307  Bit Score: 116.02  E-value: 3.42e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919009075    2 FAAGQYWIFGANGEKIWCLRDCFATLGLVGLMGICCFVIIFCGLKTFRKMIEVQGSMSKQTAALNKQLFLTLTLQTLLPF 81
Cdd:pfam10326 174 YVGPVYYPTDENGSKVIRWRSLIGLLIMTFIIGISFSIIIYCGIKMYFKMKKLKSLGSEKTRKLQKQLFKALVIQTLIPT 253

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 919009075   82 ILMYGPVGLIFFAPLFEWNLQLFVSSAGATTAIYPAFEPLIVIFCISLFRNAVF 135
Cdd:pfam10326 254 ILMYIPVGILFLLPLFNIEIGFLSGIITATIALYPAIDPLPAMFIIKEYRNAIK 307
7TM_GPCR_Srj pfam10319
Serpentine type 7TM GPCR chemoreceptor Srj; Chemoreception is mediated in Caenorhabditis ...
 27-134 1.69e-04

Serpentine type 7TM GPCR chemoreceptor Srj; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srj is part of the Str superfamily of chemoreceptors. The srj family is designated as the out-group based on its location in preliminary phylogenetic analyses of the entire superfamily. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 370974  Cd Length: 310  Bit Score: 40.30  E-value: 1.69e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919009075   27 LGLVGLMGICCFVIIFC---GLKTFRKMIEVQGSMSKQTAALNKQLFLTLTLQTLLPFILMYGPVGLIFFAPLF-----E 98
Cdd:pfam10319 199 LGILLLTVISVYSIILYivlGYKIMRKLNKMSVTMSKKTKRLQKQLLKALIVQTIIPICISFSPCVLAWYSPIFgidlgR 278

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 919009075   99 WNLQLFVSSAGAttaiYPAFEPLIVIFCISLFRNAV 134
Cdd:pfam10319 279 WNNYLEVIALSA----FPFIDPLAIILCLPVYRNRI 310
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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