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Conserved domains on  [gi|998806961|emb|CZJ96809|]
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Uncharacterised protein [Legionella pneumophila]

Protein Classification

GNAT family N-acetyltransferase( domain architecture ID 10136841)

GNAT family N-acetyltransferase catalyzes the transfer of an acetyl group from acetyl-CoA to a substrate

CATH:  3.40.630.30
EC:  2.3.1.-
Gene Ontology:  GO:0008080
PubMed:  10940244|9175471|15581578
SCOP:  3000403

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 57-114 1.50e-05

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


:

Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 40.34  E-value: 1.50e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 998806961  57 IIARIKNSMVGIVLFTDFESE---VFINHLYVSPIHRFKGIGSNLLKELKAFMGQRTVSYI 114
Cdd:cd04301    2 LVAEDDGEIVGFASLSPDGSGgdtAYIGDLAVLPEYRGKGIGSALLEAAEEEARERGAKRL 62
 
Name Accession Description Interval E-value
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 57-114 1.50e-05

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 40.34  E-value: 1.50e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 998806961  57 IIARIKNSMVGIVLFTDFESE---VFINHLYVSPIHRFKGIGSNLLKELKAFMGQRTVSYI 114
Cdd:cd04301    2 LVAEDDGEIVGFASLSPDGSGgdtAYIGDLAVLPEYRGKGIGSALLEAAEEEARERGAKRL 62
PhnO COG0454
N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, ...
 42-133 1.26e-04

N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, General function prediction only];


Pssm-ID: 440222 [Multi-domain]  Cd Length: 136  Bit Score: 39.65  E-value: 1.26e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998806961  42 ELAAyMLKPENYKYAIIARIKNSMVGIVLFTDFESEV-FINHLYVSPIHRFKGIGSNLLKELKAFMGQRTVSYIdtsnny 120
Cdd:COG0454   23 ELKA-MEGSLAGAEFIAVDDKGEPIGFAGLRRLDDKVlELKRLYVLPEYRGKGIGKALLEALLEWARERGCTAL------ 95

                         90
                 ....*....|...
gi 998806961 121 mpWMEVLDVSKKA 133
Cdd:COG0454   96 --ELDTLDGNPAA 106
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 65-114 3.46e-04

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 37.88  E-value: 3.46e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 998806961   65 MVGIVLFTDFESEVFINHLYVSPIHRFKGIGSNLLKELKAFMGQRTVSYI 114
Cdd:pfam00583  47 FASLSIIDDEPPVGEIEGLAVAPEYRGKGIGTALLQALLEWARERGCERI 96
 
Name Accession Description Interval E-value
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 57-114 1.50e-05

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 40.34  E-value: 1.50e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 998806961  57 IIARIKNSMVGIVLFTDFESE---VFINHLYVSPIHRFKGIGSNLLKELKAFMGQRTVSYI 114
Cdd:cd04301    2 LVAEDDGEIVGFASLSPDGSGgdtAYIGDLAVLPEYRGKGIGSALLEAAEEEARERGAKRL 62
PhnO COG0454
N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, ...
 42-133 1.26e-04

N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, General function prediction only];


Pssm-ID: 440222 [Multi-domain]  Cd Length: 136  Bit Score: 39.65  E-value: 1.26e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998806961  42 ELAAyMLKPENYKYAIIARIKNSMVGIVLFTDFESEV-FINHLYVSPIHRFKGIGSNLLKELKAFMGQRTVSYIdtsnny 120
Cdd:COG0454   23 ELKA-MEGSLAGAEFIAVDDKGEPIGFAGLRRLDDKVlELKRLYVLPEYRGKGIGKALLEALLEWARERGCTAL------ 95

                         90
                 ....*....|...
gi 998806961 121 mpWMEVLDVSKKA 133
Cdd:COG0454   96 --ELDTLDGNPAA 106
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 65-114 3.46e-04

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 37.88  E-value: 3.46e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 998806961   65 MVGIVLFTDFESEVFINHLYVSPIHRFKGIGSNLLKELKAFMGQRTVSYI 114
Cdd:pfam00583  47 FASLSIIDDEPPVGEIEGLAVAPEYRGKGIGTALLQALLEWARERGCERI 96
Acetyltransf_7 pfam13508
Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.
 57-119 4.08e-04

Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.


Pssm-ID: 463905 [Multi-domain]  Cd Length: 84  Bit Score: 37.05  E-value: 4.08e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 998806961   57 IIARIKNSMVG--IVLFTDFESEVFINHLYVSPIHRFKGIGSNLLKELKAFMGQRTVSYIDTSNN 119
Cdd:pfam13508   6 FVAEDDGKIVGfaALLPLDDEGALAELRLAVHPEYRGQGIGRALLEAAEAAAKEGGIKLLELETT 70
Acetyltransf_10 pfam13673
Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase ...
 38-105 1.10e-03

Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 463953 [Multi-domain]  Cd Length: 128  Bit Score: 36.87  E-value: 1.10e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 998806961   38 MTSTELAAYMLKPENYKYAiiARIKNSMVGIVLFTDfesEVFINHLYVSPIHRFKGIGSNLLKELKAF 105
Cdd:pfam13673  17 ISPEALRERIDQGEYFFFV--AFEGGQIVGVIALRD---RGHISLLFVDPDYQGQGIGKALLEAVEDY 79
RimI COG0456
Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal ...
 68-133 1.14e-03

Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440224 [Multi-domain]  Cd Length: 92  Bit Score: 36.17  E-value: 1.14e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 998806961  68 IVLFTDFESEVFINHLYVSPIHRFKGIGSNLLKELKAFMGQRTVSYIdtsnnympWMEVLDVSKKA 133
Cdd:COG0456    4 LLGLVDGGDEAEIEDLAVDPEYRGRGIGRALLEAALERARERGARRL--------RLEVREDNEAA 61
yhbS COG3153
Predicted N-acetyltransferase YhbS [General function prediction only];
42-114 1.62e-03

Predicted N-acetyltransferase YhbS [General function prediction only];


Pssm-ID: 442387 [Multi-domain]  Cd Length: 142  Bit Score: 36.60  E-value: 1.62e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 998806961  42 ELAAYMLKPENYKYAIIARIKNSMVGIVLFTDFESE-----VFINHLYVSPIHRFKGIGSNLLKELKAFMGQRTVSYI 114
Cdd:COG3153   27 ELVDRLREDPAAGLSLVAEDDGEIVGHVALSPVDIDgegpaLLLGPLAVDPEYRGQGIGRALMRAALEAARERGARAV 104
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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