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Conserved domains on  [gi|1003717143|emb|CZR14578|]
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Serpentine Receptor, class J [Caenorhabditis elegans]

Protein Classification

serpentine receptor( domain architecture ID 366230)

serpentine receptor, also known as seven TM receptor (Str), belongs to a family of seven-transmembrane (7TM) G protein-coupled receptors involved in chemoreception, a central sense of soil nematodes like Caenorhabditis elegans

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
7TM_GPCR_Srd super family cl22924
Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis ...
 1-221 5.34e-99

Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srd is part of the larger Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


The actual alignment was detected with superfamily member pfam10319:

Pssm-ID: 419896  Cd Length: 310  Bit Score: 291.07  E-value: 5.34e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1003717143   1 MSNRCGFISLSYALLIIHFVYRYMALFHADKLPIFFQPLGIIISIIFLLMHAASWSVICQQCLAGNEEVREIISIDFLEN 80
Cdd:pfam10319  92 LSARCSFISASYAVLLIHFIYRYLVLFNPQLTRHYFRPWGILISILFFLFHGSVWTAICYFLLRANDEIRDYIREDFRET 171

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1003717143  81 FGANSKSLPMLAAIYYDASDYIRFRSWLGIFLLTAFSFYAMSVYIILGFKIMRKITLMQSTnkLSKNSIRLQKQLFQTLI 160
Cdd:pfam10319 172 YGVDSMDINMLGALYWEASDETVFRSWLGILLLTVISVYSIILYIVLGYKIMRKLNKMSVT--MSKKTKRLQKQLLKALI 249

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1003717143 161 IQTCIPIIGSFLPTVISWYAPIFGVNMEWWNMNVATVAMAAFPFIDPLAVIYLIPSYRNAI 221
Cdd:pfam10319 250 VQTIIPICISFSPCVLAWYSPIFGIDLGRWNNYLEVIALSAFPFIDPLAIILCLPVYRNRI 310
 
Name Accession Description Interval E-value
7TM_GPCR_Srj pfam10319
Serpentine type 7TM GPCR chemoreceptor Srj; Chemoreception is mediated in Caenorhabditis ...
 1-221 5.34e-99

Serpentine type 7TM GPCR chemoreceptor Srj; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srj is part of the Str superfamily of chemoreceptors. The srj family is designated as the out-group based on its location in preliminary phylogenetic analyses of the entire superfamily. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 370974  Cd Length: 310  Bit Score: 291.07  E-value: 5.34e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1003717143   1 MSNRCGFISLSYALLIIHFVYRYMALFHADKLPIFFQPLGIIISIIFLLMHAASWSVICQQCLAGNEEVREIISIDFLEN 80
Cdd:pfam10319  92 LSARCSFISASYAVLLIHFIYRYLVLFNPQLTRHYFRPWGILISILFFLFHGSVWTAICYFLLRANDEIRDYIREDFRET 171

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1003717143  81 FGANSKSLPMLAAIYYDASDYIRFRSWLGIFLLTAFSFYAMSVYIILGFKIMRKITLMQSTnkLSKNSIRLQKQLFQTLI 160
Cdd:pfam10319 172 YGVDSMDINMLGALYWEASDETVFRSWLGILLLTVISVYSIILYIVLGYKIMRKLNKMSVT--MSKKTKRLQKQLLKALI 249

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1003717143 161 IQTCIPIIGSFLPTVISWYAPIFGVNMEWWNMNVATVAMAAFPFIDPLAVIYLIPSYRNAI 221
Cdd:pfam10319 250 VQTIIPICISFSPCVLAWYSPIFGIDLGRWNNYLEVIALSAFPFIDPLAIILCLPVYRNRI 310
 
Name Accession Description Interval E-value
7TM_GPCR_Srj pfam10319
Serpentine type 7TM GPCR chemoreceptor Srj; Chemoreception is mediated in Caenorhabditis ...
 1-221 5.34e-99

Serpentine type 7TM GPCR chemoreceptor Srj; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srj is part of the Str superfamily of chemoreceptors. The srj family is designated as the out-group based on its location in preliminary phylogenetic analyses of the entire superfamily. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 370974  Cd Length: 310  Bit Score: 291.07  E-value: 5.34e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1003717143   1 MSNRCGFISLSYALLIIHFVYRYMALFHADKLPIFFQPLGIIISIIFLLMHAASWSVICQQCLAGNEEVREIISIDFLEN 80
Cdd:pfam10319  92 LSARCSFISASYAVLLIHFIYRYLVLFNPQLTRHYFRPWGILISILFFLFHGSVWTAICYFLLRANDEIRDYIREDFRET 171

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1003717143  81 FGANSKSLPMLAAIYYDASDYIRFRSWLGIFLLTAFSFYAMSVYIILGFKIMRKITLMQSTnkLSKNSIRLQKQLFQTLI 160
Cdd:pfam10319 172 YGVDSMDINMLGALYWEASDETVFRSWLGILLLTVISVYSIILYIVLGYKIMRKLNKMSVT--MSKKTKRLQKQLLKALI 249

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1003717143 161 IQTCIPIIGSFLPTVISWYAPIFGVNMEWWNMNVATVAMAAFPFIDPLAVIYLIPSYRNAI 221
Cdd:pfam10319 250 VQTIIPICISFSPCVLAWYSPIFGIDLGRWNNYLEVIALSAFPFIDPLAIILCLPVYRNRI 310
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
 5-222 1.63e-41

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402099  Cd Length: 307  Bit Score: 143.75  E-value: 1.63e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1003717143   5 CGFISLSYALLIIHFVYRYMALFHADKLpIFFQPLGIIISIIFLLMHAASWSVICQQCLAGNEEVREIISIDFLENFGAN 84
Cdd:pfam10326  90 CGFYGVSISLLAVQFIYRYLALCRPGKL-KYFDGKKLILWFLYPLIFGAIWGLLVYFFLGPDEETDEYLREELLENYNLD 168

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1003717143  85 SKSLPMLAAIYY----DASDYIRFRSWLGIFLLTAFSFYAMSVYIILGFKIMRKITLMQSTNklSKNSIRLQKQLFQTLI 160
Cdd:pfam10326 169 IDEVAYVGPVYYptdeNGSKVIRWRSLIGLLIMTFIIGISFSIIIYCGIKMYFKMKKLKSLG--SEKTRKLQKQLFKALV 246

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1003717143 161 IQTCIPIIGSFLPTVISWYAPIFGVNMEWWNmNVATVAMAAFPFIDPLAVIYLIPSYRNAIL 222
Cdd:pfam10326 247 IQTLIPTILMYIPVGILFLLPLFNIEIGFLS-GIITATIALYPAIDPLPAMFIIKEYRNAIK 307
7TM_GPCR_Srd pfam10317
Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis ...
 5-223 1.62e-10

Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srd is part of the larger Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402094  Cd Length: 292  Bit Score: 59.87  E-value: 1.62e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1003717143   5 CGFISLSYALLIIHFVYRYMALFHADKLPIFFQPLGIIISIIFLLMHAASWSVICQQCLAGNEEVREIISIDF-LENFGA 83
Cdd:pfam10317  90 QHFLLHSGWSLLLTFYYRYYILKHVDPKRKKLILLIIIHYIPSLSQLIVIFLSPTDFLPVEALTKELHPNYNLtDYTVTG 169

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1003717143  84 NSkslpmlaaiyydasDYIRFRSWLGIFLLTAFSFYAMSVYIILGFKIMRKITLMQSTnkLSKNSIRLQKQLFQTLIIQT 163
Cdd:pfam10317 170 FS--------------DLQSFPALINTLIMTIPVFPIPIIILILRRKILKLLNSNSVN--MSPTTKAQHRQLIKGLTIQA 233

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1003717143 164 CIPIIgSFLPTVISWYAPIFGVNMEWWNMNVATVAMAAFPFIDPLAVIYLIPSYRNAILR 223
Cdd:pfam10317 234 LLPLF-SYIPGVTLYLLSQLTGTEFLILEYFIFVLPALPPLLDPLITIYFVTPYRRAILR 292
7TM_GPCR_Srh pfam10318
Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis ...
 98-223 1.01e-07

Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srh is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402095  Cd Length: 302  Bit Score: 51.77  E-value: 1.01e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1003717143  98 ASDYIRFRSWLGIFLLTAFSFyaMSVYIILGFKIMRKitlmQSTNKLSKNSIRLQKQLFQTLIIQTCIPIIGSFLPTVIS 177
Cdd:pfam10318 180 AIDSTYFLICIVLLILILIIQ--ILFFVFLTIYYLFK----SVKSSLSKKTRKLQKKFFIALIIQVSIPLIVILIPLIYI 253

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1003717143 178 WYAPIFGV-NMEWwnMNVATVAMAAFPFIDPLAVIYLIPSYRNAILR 223
Cdd:pfam10318 254 LFSIIFGYyNQAL--NNLLFIIISLHGLLSTIAMLLVHKPYRKFVLS 298
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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