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Conserved domains on  [gi|285812431|tpg|DAA08331|]
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TPA: 6-phosphofructokinase subunit alpha [Saccharomyces cerevisiae S288C]

Protein Classification

ATP-dependent 6-phosphofructokinase( domain architecture ID 1572373)

ATP-dependent 6-phosphofructokinase catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committed step of glycolysis

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
6PF1K_euk super family cl37119
6-phosphofructokinase, eukaryotic type; Members of this family are eukaryotic (with one ...
206-972 0e+00

6-phosphofructokinase, eukaryotic type; Members of this family are eukaryotic (with one exception) ATP-dependent 6-phosphofructokinases (EC 2.7.1.11) in which two tandem copies of the phosphofructokinase are found. Members are found, often including several isozymes, in animals and fungi and in the bacterium Propionibacterium acnes KPA171202 (a human skin commensal).


The actual alignment was detected with superfamily member TIGR02478:

Pssm-ID: 274152 [Multi-domain]  Cd Length: 746  Bit Score: 1154.40  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285812431  206 KKIAVMTSGGDSPGMNAAVRAVVRTGIHFGCDVFAVYEGYEGLLRGGKYLKKMAWEDVRGWLSEGGTLIGTARSMEFRKR 285
Cdd:TIGR02478   1 KRIAVLTSGGDAQGMNAAVRAVVRMAIYVGCRVYAIREGYQGLVDGGDNIEEAQWEDVRGILSLGGTIIGTARCKEFRER 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285812431  286 EGRRQAAGNLISQGIDALVVCGGDGSLTGADLFRHEWPSLVDELVAEGRFTKEEVAPYKNLSIVGLVGSIDNDMSGTDST 365
Cdd:TIGR02478  81 PGRLKAARNLVSNGIDALVVIGGDGSLTGADLFREEWPSLLEELVDTGKITAEQAEEHRHLTIVGLVGSIDNDMCGTDMT 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285812431  366 IGAYSALERICEMVDYIDATAKSHSRAFVVEVMGRHCGWLALMAGIATGADYIFIPERAvPHGKWQDELKEVCQRHRSKG 445
Cdd:TIGR02478 161 IGADSALHRICEAIDAISSTAQSHQRAFVVEVMGRHCGYLALMAAIATGADYVFIPERP-PEEGWEDQLCHKLKRNRKAG 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285812431  446 RRNNTIIVAEGALDDQLNPVTANDVKDALIE-LGLDTKVTILGHVQRGGTAVAHDRWLATLQGVDAVKAVLEFTPETPSP 524
Cdd:TIGR02478 240 KRKTIVIVAEGAIDRDLNPITSEDVKDVLVErLGLDTRITVLGHVQRGGAPSAFDRILATRQGVEAVLAVLESTPETPSP 319
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285812431  525 LIGILENKIIRMPLVESVKLTKSVATAIENKDFDKAISLRDTEFIELYENFLSTTVKDDGSELLPVS-DRLNIGIVHVGA 603
Cdd:TIGR02478 320 VISLRGNKIVRKPLVEAVAQTKTVAKAIEEKDFDEAMRLRGREFAENLETFLFLSIPDDDKKLVPSEaSRLRIAIIHVGA 399
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285812431  604 PSAALNAATRAATLYCLSHGHKPYAIMNGFSGLIqTGEVKELSWIDVENWHNLGGSEIGTNRSVASEDLGTIAYYFQKNK 683
Cdd:TIGR02478 400 PAGGMNAATRSAVRYALARGHTVIAIHNGFSGLA-RHDVRELTWSDVEGWVGEGGSELGTNRSLPGDDLGTIAYYFQQHK 478
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285812431  684 LDGLIILGGFEGFRSLKQLRDGRTQHPIFNIPMCLIPATVSNNVPGTEYSLGVDTCLNALVNYTDDIKQSASATRRRVFV 763
Cdd:TIGR02478 479 IDGLIIIGGFEAFEALYQLDAAREKYPAFRIPMVVIPATISNNVPGTEYSLGSDTALNEITEYCDNIKQSASASKRRVFV 558
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285812431  764 CEVQGGHSGYIASFTGLITGAVSVYTPEKKIDLASIREDITLLKENFRHDkgenRNGKLLVRNEQASSVYSTQLLADIIS 843
Cdd:TIGR02478 559 VETMGGYSGYLATMAGLATGADAAYIPEEGISLKDLQEDIEHLKETFAEG----RAGKLILRNEKASKVYTTDFIARIIS 634
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285812431  844 EASKGKFGVRTAIPGHVQQGGVPSSKDRVTASRFAVKCIKFIEQWNKKNEASPNTDAkvlrfkfdthgekvptvehEDDS 923
Cdd:TIGR02478 635 EEGKGRFDARTAVLGHMQQGGSPSPFDRVRATRLAIRAVDFIEEKIKANKHADKLSA-------------------DDTS 695
                         730       740       750       760
                  ....*....|....*....|....*....|....*....|....*....
gi 285812431  924 AAVICVNGSHVSFKPIANLWENETNVELRKGFEVHWAEYNKIGDILSGR 972
Cdd:TIGR02478 696 AVVIGIRGSNVLFTPVKQLLANETDFEHRRPKNQWWLQLRPLVRILAGR 744
Pfk_N super family cl39800
Phosphofructokinase N-terminal domain yeast; This is a phosphofructokinase (Pfk) N-terminal ...
8-101 1.79e-31

Phosphofructokinase N-terminal domain yeast; This is a phosphofructokinase (Pfk) N-terminal domain found in yeast ATP-dependent 6-phosphofructokinase subunit alpha. ATP-dependent 6-phosphofructokinases (Pfks, EC 2.7.1.11) catalyze the phosphorylation of fructose 6-phosphate (F-6-P) to fructose 1,6-bisphosphate, a key control step of glycolysis in most organizms. The N-terminal domain contains the active site and is related to glyoxalase I (E.C. 4.4.1.5).


The actual alignment was detected with superfamily member pfam18468:

Pssm-ID: 408261  Cd Length: 98  Bit Score: 118.40  E-value: 1.79e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285812431    8 YGVAFRSIITNDEALFKKTIHFYHTLGFATVKDFNKFKHGENSLLssGTSQDSLREVWLESFKLSEVDASGFRIPQQEAT 87
Cdd:pfam18468   1 SGLSFISFVTNDPDKFEATIKFYTKLGFSATKSYSKDTNNDFELI--GVSTDSIKEIWLESFPLSEVDSHGFRIPWQESP 78
                          90       100
                  ....*....|....*....|
gi 285812431   88 N------KAQSQGALLKIRL 101
Cdd:pfam18468  79 GyqgdysPKLSDGVVIKLRL 98
 
Name Accession Description Interval E-value
6PF1K_euk TIGR02478
6-phosphofructokinase, eukaryotic type; Members of this family are eukaryotic (with one ...
206-972 0e+00

6-phosphofructokinase, eukaryotic type; Members of this family are eukaryotic (with one exception) ATP-dependent 6-phosphofructokinases (EC 2.7.1.11) in which two tandem copies of the phosphofructokinase are found. Members are found, often including several isozymes, in animals and fungi and in the bacterium Propionibacterium acnes KPA171202 (a human skin commensal).


Pssm-ID: 274152 [Multi-domain]  Cd Length: 746  Bit Score: 1154.40  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285812431  206 KKIAVMTSGGDSPGMNAAVRAVVRTGIHFGCDVFAVYEGYEGLLRGGKYLKKMAWEDVRGWLSEGGTLIGTARSMEFRKR 285
Cdd:TIGR02478   1 KRIAVLTSGGDAQGMNAAVRAVVRMAIYVGCRVYAIREGYQGLVDGGDNIEEAQWEDVRGILSLGGTIIGTARCKEFRER 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285812431  286 EGRRQAAGNLISQGIDALVVCGGDGSLTGADLFRHEWPSLVDELVAEGRFTKEEVAPYKNLSIVGLVGSIDNDMSGTDST 365
Cdd:TIGR02478  81 PGRLKAARNLVSNGIDALVVIGGDGSLTGADLFREEWPSLLEELVDTGKITAEQAEEHRHLTIVGLVGSIDNDMCGTDMT 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285812431  366 IGAYSALERICEMVDYIDATAKSHSRAFVVEVMGRHCGWLALMAGIATGADYIFIPERAvPHGKWQDELKEVCQRHRSKG 445
Cdd:TIGR02478 161 IGADSALHRICEAIDAISSTAQSHQRAFVVEVMGRHCGYLALMAAIATGADYVFIPERP-PEEGWEDQLCHKLKRNRKAG 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285812431  446 RRNNTIIVAEGALDDQLNPVTANDVKDALIE-LGLDTKVTILGHVQRGGTAVAHDRWLATLQGVDAVKAVLEFTPETPSP 524
Cdd:TIGR02478 240 KRKTIVIVAEGAIDRDLNPITSEDVKDVLVErLGLDTRITVLGHVQRGGAPSAFDRILATRQGVEAVLAVLESTPETPSP 319
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285812431  525 LIGILENKIIRMPLVESVKLTKSVATAIENKDFDKAISLRDTEFIELYENFLSTTVKDDGSELLPVS-DRLNIGIVHVGA 603
Cdd:TIGR02478 320 VISLRGNKIVRKPLVEAVAQTKTVAKAIEEKDFDEAMRLRGREFAENLETFLFLSIPDDDKKLVPSEaSRLRIAIIHVGA 399
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285812431  604 PSAALNAATRAATLYCLSHGHKPYAIMNGFSGLIqTGEVKELSWIDVENWHNLGGSEIGTNRSVASEDLGTIAYYFQKNK 683
Cdd:TIGR02478 400 PAGGMNAATRSAVRYALARGHTVIAIHNGFSGLA-RHDVRELTWSDVEGWVGEGGSELGTNRSLPGDDLGTIAYYFQQHK 478
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285812431  684 LDGLIILGGFEGFRSLKQLRDGRTQHPIFNIPMCLIPATVSNNVPGTEYSLGVDTCLNALVNYTDDIKQSASATRRRVFV 763
Cdd:TIGR02478 479 IDGLIIIGGFEAFEALYQLDAAREKYPAFRIPMVVIPATISNNVPGTEYSLGSDTALNEITEYCDNIKQSASASKRRVFV 558
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285812431  764 CEVQGGHSGYIASFTGLITGAVSVYTPEKKIDLASIREDITLLKENFRHDkgenRNGKLLVRNEQASSVYSTQLLADIIS 843
Cdd:TIGR02478 559 VETMGGYSGYLATMAGLATGADAAYIPEEGISLKDLQEDIEHLKETFAEG----RAGKLILRNEKASKVYTTDFIARIIS 634
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285812431  844 EASKGKFGVRTAIPGHVQQGGVPSSKDRVTASRFAVKCIKFIEQWNKKNEASPNTDAkvlrfkfdthgekvptvehEDDS 923
Cdd:TIGR02478 635 EEGKGRFDARTAVLGHMQQGGSPSPFDRVRATRLAIRAVDFIEEKIKANKHADKLSA-------------------DDTS 695
                         730       740       750       760
                  ....*....|....*....|....*....|....*....|....*....
gi 285812431  924 AAVICVNGSHVSFKPIANLWENETNVELRKGFEVHWAEYNKIGDILSGR 972
Cdd:TIGR02478 696 AVVIGIRGSNVLFTPVKQLLANETDFEHRRPKNQWWLQLRPLVRILAGR 744
Eukaryotic_PFK cd00764
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ...
204-954 0e+00

Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent phosphofructokinases. These have evolved from the bacterial PFKs by gene duplication and fusion events and exhibit complex allosteric behavior.


Pssm-ID: 238389 [Multi-domain]  Cd Length: 762  Bit Score: 1143.40  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285812431 204 KKKKIAVMTSGGDSPGMNAAVRAVVRTGIHFGCDVFAVYEGYEGLLRGGKYLKKMAWEDVRGWLSEGGTLIGTARSMEFR 283
Cdd:cd00764    2 AGKAIAVLTSGGDAQGMNAAVRAVVRMGIYVGAKVFFVYEGYEGLVKGGDYIKQAEWESVSNWLQEGGTIIGSARCKEFR 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285812431 284 KREGRRQAAGNLISQGIDALVVCGGDGSLTGADLFRHEWPSLVDELVAEGRFTKEEVAPYKNLSIVGLVGSIDNDMSGTD 363
Cdd:cd00764   82 EREGRLQAAYNLIQRGITNLCVIGGDGSLTGADLFRSEWPSLLEELVKDGKITEEEVAKYQHLNIVGMVGSIDNDFCGTD 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285812431 364 STIGAYSALERICEMVDYIDATAKSHSRAFVVEVMGRHCGWLALMAGIATGADYIFIPERAvPHGKWQDELKEVCQRHRS 443
Cdd:cd00764  162 MTIGTDSALHRICEVVDAITTTAQSHQRTFVLEVMGRHCGYLALVSGLATGADWIFIPERP-PEDGWEDQMCRRLSEHRS 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285812431 444 KGRRNNTIIVAEGALDDQLNPVTANDVKDALIE-LGLDTKVTILGHVQRGGTAVAHDRWLATLQGVDAVKAVLEFTPETP 522
Cdd:cd00764  241 RGKRLNIIIVAEGAIDDQLKPITSEDVKDLVVErLGLDTRVTTLGHVQRGGTPSAFDRILASLMGVEAVMALLEATPDTP 320
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285812431 523 SPLIGILENKIIRMPLVESVKLTKSV-----------ATAIENKDFDKAISLRDTEFIELYenflsttvkddgsELLPVS 591
Cdd:cd00764  321 ACVVSLNGNKAVRLPLMECVQLTKDVqkamdekrfdeAAALRGKSFDKNWNLYKLLAIELP-------------QPLPEK 387
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285812431 592 DRLNIGIVHVGAPSAALNAATRAATLYCLSHGHKPYAIMNGFSGLIQtGEVKELSWIDVENWHNLGGSEIGTNRSVASED 671
Cdd:cd00764  388 TNLNIAIVNVGAPAAGMNAAVRSAVRYGLAHGHRPYAIYDGFEGLAK-GQIVELGWIDVGGWTGRGGSELGTKRTLPKKD 466
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285812431 672 LGTIAYYFQKNKLDGLIILGGFEGFRSLKQLRDGRTQHPIFNIPMCLIPATVSNNVPGTEYSLGVDTCLNALVNYTDDIK 751
Cdd:cd00764  467 LETIAYNFQKYGIDGLIIVGGFEAYKGLLQLREAREQYEEFCIPMVLIPATVSNNVPGTDFSLGSDTALNALMKYCDRIK 546
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285812431 752 QSASATRRRVFVCEVQGGHSGYIASFTGLITGAVSVYTPEKKIDLASIREDITLLKENFRHDKGENRNGKLLVRNEQASS 831
Cdd:cd00764  547 QSASGTKRRVFIVETMGGYCGYLATMTGLAVGADAAYVFEEPFNIRDLQENVEHLTEKMKTTIGRGLVLRNEKCNENYTT 626
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285812431 832 VYSTQLLADIIseasKGKFGVRTAIPGHVQQGGVPSSKDRVTASRFAVKCIKFIEQWNKKNEASPNTDAKVLRFK----- 906
Cdd:cd00764  627 VFTYELYSEEG----KGVFDCRTNVLGHVQQGGAPSPFDRNFGTKFAVKAMKWIEQKLKENYAAGNEFANDPDFNcvngv 702
                        730       740       750       760       770
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 285812431 907 -----FDTHGE--KVPTVEH----EDDSAAVICVNGSHVSFKPIANLWENETNVELRKG 954
Cdd:cd00764  703 kkyavLFEPVEelKQTTFEHripkEQWWLSLRPLLKILAKYKISADISDHGQLEHVTRG 761
PFK pfam00365
Phosphofructokinase;
207-512 5.22e-137

Phosphofructokinase;


Pssm-ID: 459783 [Multi-domain]  Cd Length: 271  Bit Score: 411.73  E-value: 5.22e-137
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285812431  207 KIAVMTSGGDSPGMNAAVRAVVRTGIHFGCDVFAVYEGYEGLLRGGkyLKKMAWEDVRGWLSEGGTLIGTARSMEFRKRE 286
Cdd:pfam00365   1 RIGILTSGGDAPGMNAAIRAVVRTAIYRGHEVYGIRNGYEGLVEGD--IDELTWRDVSGILNRGGTILGTSRSKPFKTEE 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285812431  287 GRRQAAGNLISQGIDALVVCGGDGSLTGADLFRHEWpslvdelvaegrftkeevapykNLSIVGLVGSIDNDMSGTDSTI 366
Cdd:pfam00365  79 GREKIAENLKKLGIDALVVIGGDGSLTGANKLSEER----------------------GIPVVGIPKTIDNDIPGTDYTI 136
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285812431  367 GAYSALERICEMVDYIDATAKSHSRAFVVEVMGRHCGWLALMAGIATGADYIFIPERAVphgkwqdELKEVCQ--RHRSK 444
Cdd:pfam00365 137 GFDTALNTIVEAIDRIRDTASSHNRVFVVEVMGRHCGWLALMAGLAGGADAILIPEIPF-------DIEELCEkiKELRK 209
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 285812431  445 GRRNNTIIVAEGALDdqlnpvtANDVKDALIE-LGLDTKVTILGHVQRGGTAVAHDRWLATLQGVDAVK 512
Cdd:pfam00365 210 GKRFSIIVVAEGASD-------GEFLAKLIEEgTGIETRVTVLGHVQRGGTPSAFDRILATRLGVKAVE 271
PRK03202 PRK03202
ATP-dependent 6-phosphofructokinase;
206-548 1.64e-116

ATP-dependent 6-phosphofructokinase;


Pssm-ID: 235111 [Multi-domain]  Cd Length: 320  Bit Score: 360.16  E-value: 1.64e-116
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285812431 206 KKIAVMTSGGDSPGMNAAVRAVVRTGIHFGCDVFAVYEGYEGLLRGgkYLKKMAWEDVRGWLSEGGTLIGTARSMEFRKR 285
Cdd:PRK03202   2 KRIGVLTSGGDAPGMNAAIRAVVRTAISEGLEVYGIYDGYAGLLEG--DIVKLDLKSVSDIINRGGTILGSARFPEFKDE 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285812431 286 EGRRQAAGNLISQGIDALVVCGGDGSLTGA-DLFRHEWPslvdelvaegrftkeevapyknlsIVGLVGSIDNDMSGTDS 364
Cdd:PRK03202  80 EGRAKAIENLKKLGIDALVVIGGDGSYMGAkRLTEHGIP------------------------VIGLPGTIDNDIAGTDY 135
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285812431 365 TIGAYSALERICEMVDYIDATAKSHSRAFVVEVMGRHCGWLALMAGIATGADYIFIPERAVPHgkwqDELKEVCQRHRSK 444
Cdd:PRK03202 136 TIGFDTALNTAVEAIDRLRDTASSHERVFIVEVMGRHAGDLALHAGIAGGAEVILIPEVPFDI----EELCAKIKKGRER 211
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285812431 445 GRRNNTIIVAEGALDdqlnpvtANDVKDALIE-LGLDTKVTILGHVQRGGTAVAHDRWLATLQGVDAVKAVLEftpETPS 523
Cdd:PRK03202 212 GKKHAIIVVAEGVMP-------AEELAKEIEErTGLETRVTVLGHIQRGGSPTAFDRVLASRMGAHAVELLLE---GKGG 281
                        330       340
                 ....*....|....*....|....*
gi 285812431 524 PLIGILENKIIRMPLVESVKLTKSV 548
Cdd:PRK03202 282 RMVGIQNNKIVHVPIEEAVENMKHP 306
PfkA COG0205
6-phosphofructokinase [Carbohydrate transport and metabolism]; 6-phosphofructokinase is part ...
205-548 1.41e-114

6-phosphofructokinase [Carbohydrate transport and metabolism]; 6-phosphofructokinase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 439975 [Multi-domain]  Cd Length: 344  Bit Score: 355.92  E-value: 1.41e-114
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285812431 205 KKKIAVMTSGGDSPGMNAAVRAVVRTGIHFGCDVFAVYEGYEGLLRGGkyLKKMAWEDVRGWLSEGGTLIGTARSMEFRK 284
Cdd:COG0205    1 MKRIGILTSGGDAPGLNAAIRAVVRTAIKYGIEVYGIRDGYEGLLEGD--IIDLTREDVSGILQRGGTILGSSRSKPFKT 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285812431 285 REGRRQAAGNLISQGIDALVVCGGDGSLTGADLFrHEwpslvdelvaegrftkeevapYKNLSIVGLVGSIDNDMSGTDS 364
Cdd:COG0205   79 EEGREKALENLKKLGIDALVVIGGDGSLDGAAKL-AE---------------------EYGIPVVGIPKTIDNDLPGTDY 136
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285812431 365 TIGAYSALERICEMVDYIDATAKSHSRAFVVEVMGRHCGWLALMAGIATGADYIFIPERAVPhgkwQDELKEVCQRHRSK 444
Cdd:COG0205  137 TIGFDTAVNTAAEAIDRLRDTAASHERVFVVEVMGRHAGWLALAAGLAGGADLILIPEVPFD----LDKLLEKLKERRKR 212
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285812431 445 GRRNNTIIVAEGALDDQLNPV---------------TANDVKDALIE-LGLDTKVTILGHVQRGGTAVAHDRWLATLQGV 508
Cdd:COG0205  213 GKGYSIIVVAEGAGDEDGEAVleadtdafghvrlggIGEYLAKEIEErTGIETRVTVLGHLQRGGSPSAFDRVLASRLGA 292
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|
gi 285812431 509 DAVKAVLEftpETPSPLIGILENKIIRMPLVESVKLTKSV 548
Cdd:COG0205  293 AAVELLLE---GKTGVMVGIRRGEIVLVPLEEVANKEKPV 329
Pfk_N pfam18468
Phosphofructokinase N-terminal domain yeast; This is a phosphofructokinase (Pfk) N-terminal ...
8-101 1.79e-31

Phosphofructokinase N-terminal domain yeast; This is a phosphofructokinase (Pfk) N-terminal domain found in yeast ATP-dependent 6-phosphofructokinase subunit alpha. ATP-dependent 6-phosphofructokinases (Pfks, EC 2.7.1.11) catalyze the phosphorylation of fructose 6-phosphate (F-6-P) to fructose 1,6-bisphosphate, a key control step of glycolysis in most organizms. The N-terminal domain contains the active site and is related to glyoxalase I (E.C. 4.4.1.5).


Pssm-ID: 408261  Cd Length: 98  Bit Score: 118.40  E-value: 1.79e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285812431    8 YGVAFRSIITNDEALFKKTIHFYHTLGFATVKDFNKFKHGENSLLssGTSQDSLREVWLESFKLSEVDASGFRIPQQEAT 87
Cdd:pfam18468   1 SGLSFISFVTNDPDKFEATIKFYTKLGFSATKSYSKDTNNDFELI--GVSTDSIKEIWLESFPLSEVDSHGFRIPWQESP 78
                          90       100
                  ....*....|....*....|
gi 285812431   88 N------KAQSQGALLKIRL 101
Cdd:pfam18468  79 GyqgdysPKLSDGVVIKLRL 98
 
Name Accession Description Interval E-value
6PF1K_euk TIGR02478
6-phosphofructokinase, eukaryotic type; Members of this family are eukaryotic (with one ...
206-972 0e+00

6-phosphofructokinase, eukaryotic type; Members of this family are eukaryotic (with one exception) ATP-dependent 6-phosphofructokinases (EC 2.7.1.11) in which two tandem copies of the phosphofructokinase are found. Members are found, often including several isozymes, in animals and fungi and in the bacterium Propionibacterium acnes KPA171202 (a human skin commensal).


Pssm-ID: 274152 [Multi-domain]  Cd Length: 746  Bit Score: 1154.40  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285812431  206 KKIAVMTSGGDSPGMNAAVRAVVRTGIHFGCDVFAVYEGYEGLLRGGKYLKKMAWEDVRGWLSEGGTLIGTARSMEFRKR 285
Cdd:TIGR02478   1 KRIAVLTSGGDAQGMNAAVRAVVRMAIYVGCRVYAIREGYQGLVDGGDNIEEAQWEDVRGILSLGGTIIGTARCKEFRER 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285812431  286 EGRRQAAGNLISQGIDALVVCGGDGSLTGADLFRHEWPSLVDELVAEGRFTKEEVAPYKNLSIVGLVGSIDNDMSGTDST 365
Cdd:TIGR02478  81 PGRLKAARNLVSNGIDALVVIGGDGSLTGADLFREEWPSLLEELVDTGKITAEQAEEHRHLTIVGLVGSIDNDMCGTDMT 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285812431  366 IGAYSALERICEMVDYIDATAKSHSRAFVVEVMGRHCGWLALMAGIATGADYIFIPERAvPHGKWQDELKEVCQRHRSKG 445
Cdd:TIGR02478 161 IGADSALHRICEAIDAISSTAQSHQRAFVVEVMGRHCGYLALMAAIATGADYVFIPERP-PEEGWEDQLCHKLKRNRKAG 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285812431  446 RRNNTIIVAEGALDDQLNPVTANDVKDALIE-LGLDTKVTILGHVQRGGTAVAHDRWLATLQGVDAVKAVLEFTPETPSP 524
Cdd:TIGR02478 240 KRKTIVIVAEGAIDRDLNPITSEDVKDVLVErLGLDTRITVLGHVQRGGAPSAFDRILATRQGVEAVLAVLESTPETPSP 319
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285812431  525 LIGILENKIIRMPLVESVKLTKSVATAIENKDFDKAISLRDTEFIELYENFLSTTVKDDGSELLPVS-DRLNIGIVHVGA 603
Cdd:TIGR02478 320 VISLRGNKIVRKPLVEAVAQTKTVAKAIEEKDFDEAMRLRGREFAENLETFLFLSIPDDDKKLVPSEaSRLRIAIIHVGA 399
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285812431  604 PSAALNAATRAATLYCLSHGHKPYAIMNGFSGLIqTGEVKELSWIDVENWHNLGGSEIGTNRSVASEDLGTIAYYFQKNK 683
Cdd:TIGR02478 400 PAGGMNAATRSAVRYALARGHTVIAIHNGFSGLA-RHDVRELTWSDVEGWVGEGGSELGTNRSLPGDDLGTIAYYFQQHK 478
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285812431  684 LDGLIILGGFEGFRSLKQLRDGRTQHPIFNIPMCLIPATVSNNVPGTEYSLGVDTCLNALVNYTDDIKQSASATRRRVFV 763
Cdd:TIGR02478 479 IDGLIIIGGFEAFEALYQLDAAREKYPAFRIPMVVIPATISNNVPGTEYSLGSDTALNEITEYCDNIKQSASASKRRVFV 558
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285812431  764 CEVQGGHSGYIASFTGLITGAVSVYTPEKKIDLASIREDITLLKENFRHDkgenRNGKLLVRNEQASSVYSTQLLADIIS 843
Cdd:TIGR02478 559 VETMGGYSGYLATMAGLATGADAAYIPEEGISLKDLQEDIEHLKETFAEG----RAGKLILRNEKASKVYTTDFIARIIS 634
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285812431  844 EASKGKFGVRTAIPGHVQQGGVPSSKDRVTASRFAVKCIKFIEQWNKKNEASPNTDAkvlrfkfdthgekvptvehEDDS 923
Cdd:TIGR02478 635 EEGKGRFDARTAVLGHMQQGGSPSPFDRVRATRLAIRAVDFIEEKIKANKHADKLSA-------------------DDTS 695
                         730       740       750       760
                  ....*....|....*....|....*....|....*....|....*....
gi 285812431  924 AAVICVNGSHVSFKPIANLWENETNVELRKGFEVHWAEYNKIGDILSGR 972
Cdd:TIGR02478 696 AVVIGIRGSNVLFTPVKQLLANETDFEHRRPKNQWWLQLRPLVRILAGR 744
Eukaryotic_PFK cd00764
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ...
204-954 0e+00

Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent phosphofructokinases. These have evolved from the bacterial PFKs by gene duplication and fusion events and exhibit complex allosteric behavior.


Pssm-ID: 238389 [Multi-domain]  Cd Length: 762  Bit Score: 1143.40  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285812431 204 KKKKIAVMTSGGDSPGMNAAVRAVVRTGIHFGCDVFAVYEGYEGLLRGGKYLKKMAWEDVRGWLSEGGTLIGTARSMEFR 283
Cdd:cd00764    2 AGKAIAVLTSGGDAQGMNAAVRAVVRMGIYVGAKVFFVYEGYEGLVKGGDYIKQAEWESVSNWLQEGGTIIGSARCKEFR 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285812431 284 KREGRRQAAGNLISQGIDALVVCGGDGSLTGADLFRHEWPSLVDELVAEGRFTKEEVAPYKNLSIVGLVGSIDNDMSGTD 363
Cdd:cd00764   82 EREGRLQAAYNLIQRGITNLCVIGGDGSLTGADLFRSEWPSLLEELVKDGKITEEEVAKYQHLNIVGMVGSIDNDFCGTD 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285812431 364 STIGAYSALERICEMVDYIDATAKSHSRAFVVEVMGRHCGWLALMAGIATGADYIFIPERAvPHGKWQDELKEVCQRHRS 443
Cdd:cd00764  162 MTIGTDSALHRICEVVDAITTTAQSHQRTFVLEVMGRHCGYLALVSGLATGADWIFIPERP-PEDGWEDQMCRRLSEHRS 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285812431 444 KGRRNNTIIVAEGALDDQLNPVTANDVKDALIE-LGLDTKVTILGHVQRGGTAVAHDRWLATLQGVDAVKAVLEFTPETP 522
Cdd:cd00764  241 RGKRLNIIIVAEGAIDDQLKPITSEDVKDLVVErLGLDTRVTTLGHVQRGGTPSAFDRILASLMGVEAVMALLEATPDTP 320
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285812431 523 SPLIGILENKIIRMPLVESVKLTKSV-----------ATAIENKDFDKAISLRDTEFIELYenflsttvkddgsELLPVS 591
Cdd:cd00764  321 ACVVSLNGNKAVRLPLMECVQLTKDVqkamdekrfdeAAALRGKSFDKNWNLYKLLAIELP-------------QPLPEK 387
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285812431 592 DRLNIGIVHVGAPSAALNAATRAATLYCLSHGHKPYAIMNGFSGLIQtGEVKELSWIDVENWHNLGGSEIGTNRSVASED 671
Cdd:cd00764  388 TNLNIAIVNVGAPAAGMNAAVRSAVRYGLAHGHRPYAIYDGFEGLAK-GQIVELGWIDVGGWTGRGGSELGTKRTLPKKD 466
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285812431 672 LGTIAYYFQKNKLDGLIILGGFEGFRSLKQLRDGRTQHPIFNIPMCLIPATVSNNVPGTEYSLGVDTCLNALVNYTDDIK 751
Cdd:cd00764  467 LETIAYNFQKYGIDGLIIVGGFEAYKGLLQLREAREQYEEFCIPMVLIPATVSNNVPGTDFSLGSDTALNALMKYCDRIK 546
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285812431 752 QSASATRRRVFVCEVQGGHSGYIASFTGLITGAVSVYTPEKKIDLASIREDITLLKENFRHDKGENRNGKLLVRNEQASS 831
Cdd:cd00764  547 QSASGTKRRVFIVETMGGYCGYLATMTGLAVGADAAYVFEEPFNIRDLQENVEHLTEKMKTTIGRGLVLRNEKCNENYTT 626
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285812431 832 VYSTQLLADIIseasKGKFGVRTAIPGHVQQGGVPSSKDRVTASRFAVKCIKFIEQWNKKNEASPNTDAKVLRFK----- 906
Cdd:cd00764  627 VFTYELYSEEG----KGVFDCRTNVLGHVQQGGAPSPFDRNFGTKFAVKAMKWIEQKLKENYAAGNEFANDPDFNcvngv 702
                        730       740       750       760       770
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 285812431 907 -----FDTHGE--KVPTVEH----EDDSAAVICVNGSHVSFKPIANLWENETNVELRKG 954
Cdd:cd00764  703 kkyavLFEPVEelKQTTFEHripkEQWWLSLRPLLKILAKYKISADISDHGQLEHVTRG 761
PFK cd00363
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ...
206-562 4.43e-165

Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases. Some members evolved by gene duplication and thus have a large C-terminal/N-terminal extension comprising a second PFK domain. Generally, ATP-PFKs are allosteric homotetramers, and PPi-PFKs are dimeric and nonallosteric except for plant PPi-PFKs which are allosteric heterotetramers.


Pssm-ID: 238216 [Multi-domain]  Cd Length: 338  Bit Score: 486.81  E-value: 4.43e-165
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285812431 206 KKIAVMTSGGDSPGMNAAVRAVVRTGIHFGCDVFAVYEGYEGLLRGgkYLKKMAWEDVRGWLSEGGTLIGTARSMEFRKR 285
Cdd:cd00363    1 KKIGVLTSGGDAPGMNAAIRGVVRSAIAEGLEVYGIYEGYAGLVEG--DIKELDWESVSDIINRGGTIIGSARCKEFRTE 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285812431 286 EGRRQAAGNLISQGIDALVVCGGDGSLTGADLFRHEWPSLvdelvaegrftkeevapYKNLSIVGLVGSIDNDMSGTDST 365
Cdd:cd00363   79 EGRAKAAENLKKHGIDALVVIGGDGSYTGADLLTEEWPSK-----------------YQGFNVIGLPGTIDNDIKGTDYT 141
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285812431 366 IGAYSALERICEMVDYIDATAKSHSRAFVVEVMGRHCGWLALMAGIATGADYIFIPERaVPHGKWQDELKEVCQRHRSKG 445
Cdd:cd00363  142 IGFDTALKTIVEAIDRIRDTASSHQRTFVVEVMGRHCGDIALEAGLATGADIIFIPEE-PAADEWEEEMVDVIKKRRERG 220
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285812431 446 RRNNTIIVAEGALDDQLNPVTANDVKDALIE-LGLDTKVTILGHVQRGGTAVAHDRWLATLQGVDAVKAVLEFTPETPSP 524
Cdd:cd00363  221 KRHGIVIVAEGAIDFIPKPITEKLLAKLVEErLGFDTRATVLGHVQRGGTPTAFDRILASRLGAEAVELLLEGTGGTPVG 300
                        330       340       350
                 ....*....|....*....|....*....|....*...
gi 285812431 525 LIGILENKIIRMPLVESVKLTKSVATAIENKDFDKAIS 562
Cdd:cd00363  301 IQNLNENQVVRHPLTEAVNMTKRVGVDLEGRPFKKFAK 338
PFK pfam00365
Phosphofructokinase;
207-512 5.22e-137

Phosphofructokinase;


Pssm-ID: 459783 [Multi-domain]  Cd Length: 271  Bit Score: 411.73  E-value: 5.22e-137
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285812431  207 KIAVMTSGGDSPGMNAAVRAVVRTGIHFGCDVFAVYEGYEGLLRGGkyLKKMAWEDVRGWLSEGGTLIGTARSMEFRKRE 286
Cdd:pfam00365   1 RIGILTSGGDAPGMNAAIRAVVRTAIYRGHEVYGIRNGYEGLVEGD--IDELTWRDVSGILNRGGTILGTSRSKPFKTEE 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285812431  287 GRRQAAGNLISQGIDALVVCGGDGSLTGADLFRHEWpslvdelvaegrftkeevapykNLSIVGLVGSIDNDMSGTDSTI 366
Cdd:pfam00365  79 GREKIAENLKKLGIDALVVIGGDGSLTGANKLSEER----------------------GIPVVGIPKTIDNDIPGTDYTI 136
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285812431  367 GAYSALERICEMVDYIDATAKSHSRAFVVEVMGRHCGWLALMAGIATGADYIFIPERAVphgkwqdELKEVCQ--RHRSK 444
Cdd:pfam00365 137 GFDTALNTIVEAIDRIRDTASSHNRVFVVEVMGRHCGWLALMAGLAGGADAILIPEIPF-------DIEELCEkiKELRK 209
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 285812431  445 GRRNNTIIVAEGALDdqlnpvtANDVKDALIE-LGLDTKVTILGHVQRGGTAVAHDRWLATLQGVDAVK 512
Cdd:pfam00365 210 GKRFSIIVVAEGASD-------GEFLAKLIEEgTGIETRVTVLGHVQRGGTPSAFDRILATRLGVKAVE 271
PRK03202 PRK03202
ATP-dependent 6-phosphofructokinase;
206-548 1.64e-116

ATP-dependent 6-phosphofructokinase;


Pssm-ID: 235111 [Multi-domain]  Cd Length: 320  Bit Score: 360.16  E-value: 1.64e-116
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285812431 206 KKIAVMTSGGDSPGMNAAVRAVVRTGIHFGCDVFAVYEGYEGLLRGgkYLKKMAWEDVRGWLSEGGTLIGTARSMEFRKR 285
Cdd:PRK03202   2 KRIGVLTSGGDAPGMNAAIRAVVRTAISEGLEVYGIYDGYAGLLEG--DIVKLDLKSVSDIINRGGTILGSARFPEFKDE 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285812431 286 EGRRQAAGNLISQGIDALVVCGGDGSLTGA-DLFRHEWPslvdelvaegrftkeevapyknlsIVGLVGSIDNDMSGTDS 364
Cdd:PRK03202  80 EGRAKAIENLKKLGIDALVVIGGDGSYMGAkRLTEHGIP------------------------VIGLPGTIDNDIAGTDY 135
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285812431 365 TIGAYSALERICEMVDYIDATAKSHSRAFVVEVMGRHCGWLALMAGIATGADYIFIPERAVPHgkwqDELKEVCQRHRSK 444
Cdd:PRK03202 136 TIGFDTALNTAVEAIDRLRDTASSHERVFIVEVMGRHAGDLALHAGIAGGAEVILIPEVPFDI----EELCAKIKKGRER 211
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285812431 445 GRRNNTIIVAEGALDdqlnpvtANDVKDALIE-LGLDTKVTILGHVQRGGTAVAHDRWLATLQGVDAVKAVLEftpETPS 523
Cdd:PRK03202 212 GKKHAIIVVAEGVMP-------AEELAKEIEErTGLETRVTVLGHIQRGGSPTAFDRVLASRMGAHAVELLLE---GKGG 281
                        330       340
                 ....*....|....*....|....*
gi 285812431 524 PLIGILENKIIRMPLVESVKLTKSV 548
Cdd:PRK03202 282 RMVGIQNNKIVHVPIEEAVENMKHP 306
PfkA COG0205
6-phosphofructokinase [Carbohydrate transport and metabolism]; 6-phosphofructokinase is part ...
205-548 1.41e-114

6-phosphofructokinase [Carbohydrate transport and metabolism]; 6-phosphofructokinase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 439975 [Multi-domain]  Cd Length: 344  Bit Score: 355.92  E-value: 1.41e-114
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285812431 205 KKKIAVMTSGGDSPGMNAAVRAVVRTGIHFGCDVFAVYEGYEGLLRGGkyLKKMAWEDVRGWLSEGGTLIGTARSMEFRK 284
Cdd:COG0205    1 MKRIGILTSGGDAPGLNAAIRAVVRTAIKYGIEVYGIRDGYEGLLEGD--IIDLTREDVSGILQRGGTILGSSRSKPFKT 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285812431 285 REGRRQAAGNLISQGIDALVVCGGDGSLTGADLFrHEwpslvdelvaegrftkeevapYKNLSIVGLVGSIDNDMSGTDS 364
Cdd:COG0205   79 EEGREKALENLKKLGIDALVVIGGDGSLDGAAKL-AE---------------------EYGIPVVGIPKTIDNDLPGTDY 136
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285812431 365 TIGAYSALERICEMVDYIDATAKSHSRAFVVEVMGRHCGWLALMAGIATGADYIFIPERAVPhgkwQDELKEVCQRHRSK 444
Cdd:COG0205  137 TIGFDTAVNTAAEAIDRLRDTAASHERVFVVEVMGRHAGWLALAAGLAGGADLILIPEVPFD----LDKLLEKLKERRKR 212
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285812431 445 GRRNNTIIVAEGALDDQLNPV---------------TANDVKDALIE-LGLDTKVTILGHVQRGGTAVAHDRWLATLQGV 508
Cdd:COG0205  213 GKGYSIIVVAEGAGDEDGEAVleadtdafghvrlggIGEYLAKEIEErTGIETRVTVLGHLQRGGSPSAFDRVLASRLGA 292
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|
gi 285812431 509 DAVKAVLEftpETPSPLIGILENKIIRMPLVESVKLTKSV 548
Cdd:COG0205  293 AAVELLLE---GKTGVMVGIRRGEIVLVPLEEVANKEKPV 329
PFKA_ATP TIGR02482
6-phosphofructokinase; 6-phosphofructokinase (EC 2.7.1.11) catalyzes the addition of phosphate ...
207-542 4.49e-99

6-phosphofructokinase; 6-phosphofructokinase (EC 2.7.1.11) catalyzes the addition of phosphate from ATP to fructose 6-phosphate to give fructose 1,6-bisphosphate. This represents a key control step in glycolysis. This model hits bacterial ATP-dependent 6-phosphofructokinases which lack a beta-hairpin loop present in TIGR02483 family members. TIGR02483 contains members that are ATP-dependent as well as members that are pyrophosphate-dependent. TIGR02477 represents the pyrophosphate-dependent phosphofructokinase, diphosphate--fructose-6-phosphate 1-phosphotransferase (EC 2.7.1.90). [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 213713 [Multi-domain]  Cd Length: 301  Bit Score: 313.52  E-value: 4.49e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285812431  207 KIAVMTSGGDSPGMNAAVRAVVRTGIHFGCDVFAVYEGYEGLLRGgkYLKKMAWEDVRGWLSEGGTLIGTARSMEFRKRE 286
Cdd:TIGR02482   1 KIGILTSGGDAPGMNAAIRAVVRTAIYHGFEVYGIRRGYKGLING--KIEPLESKNVSGIIHRGGTILGTARCPEFKTEE 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285812431  287 GRRQAAGNLISQGIDALVVCGGDGSLTGADLFRHEwpslvdelvaegrftkeevapyKNLSIVGLVGSIDNDMSGTDSTI 366
Cdd:TIGR02482  79 VREKAVENLKKLGIEGLVVIGGDGSYTGAQKLYEE----------------------GGIPVIGLPGTIDNDIPGTDYTI 136
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285812431  367 GAYSALERICEMVDYIDATAKSHSRAFVVEVMGRHCGWLALMAGIATGADYIFIPERAVPHgkwqDELKEVCQRHRSKGR 446
Cdd:TIGR02482 137 GFDTALNTIIDAVDKIRDTATSHERAFVIEVMGRHAGDLALYAGIATGAEIIIIPEFDYDI----DELIQRLKEQHEAGK 212
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285812431  447 RNNTIIVAEGALDDQLNPVtANDVKDAlieLGLDTKVTILGHVQRGGTAVAHDRWLATLQGVDAVKAVLEFTPETpspLI 526
Cdd:TIGR02482 213 KHSIIIVAEGNIVGSAKEV-AKKIEEK---TGIETRVTVLGHTQRGGSPSAFDRVLASRLGAKAVELLLEGKGGV---MI 285
                         330
                  ....*....|....*.
gi 285812431  527 GILENKIIRMPLVESV 542
Cdd:TIGR02482 286 GIQNNKIVTHPIEEAL 301
PFK pfam00365
Phosphofructokinase;
595-883 2.00e-93

Phosphofructokinase;


Pssm-ID: 459783 [Multi-domain]  Cd Length: 271  Bit Score: 297.33  E-value: 2.00e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285812431  595 NIGIVHVGAPSaalnaatraaTLYCLSHGHKPYAIMNGFSGLIQtGEVKELSWIDVENWHNLGGSEIGTNRSVAS---ED 671
Cdd:pfam00365   1 RIGILTSGGDApgmnaairavVRTAIYRGHEVYGIRNGYEGLVE-GDIDELTWRDVSGILNRGGTILGTSRSKPFkteEG 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285812431  672 LGTIAYYFQKNKLDGLIILGGFEGFRSLKQLRDGRtqhpifNIPMCLIPATVSNNVPGTEYSLGVDTCLNALVNYTDDIK 751
Cdd:pfam00365  80 REKIAENLKKLGIDALVVIGGDGSLTGANKLSEER------GIPVVGIPKTIDNDIPGTDYTIGFDTALNTIVEAIDRIR 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285812431  752 QSASATrRRVFVCEVQGGHSGYIASFTGLITGAVSVYTPEKKIDLASIREDITLLKENFRHdkgenrngKLLVRNEQASs 831
Cdd:pfam00365 154 DTASSH-NRVFVVEVMGRHCGWLALMAGLAGGADAILIPEIPFDIEELCEKIKELRKGKRF--------SIIVVAEGAS- 223
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 285812431  832 vySTQLLADIISEasKGKFGVRTAIPGHVQQGGVPSSKDRVTASRFAVKCIK 883
Cdd:pfam00365 224 --DGEFLAKLIEE--GTGIETRVTVLGHVQRGGTPSAFDRILATRLGVKAVE 271
Bacterial_PFK cd00763
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ...
206-561 1.49e-84

Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent phosphofructokinases. These are allosrterically regulated homotetramers; the subunits are of about 320 amino acids.


Pssm-ID: 238388 [Multi-domain]  Cd Length: 317  Bit Score: 275.44  E-value: 1.49e-84
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285812431 206 KKIAVMTSGGDSPGMNAAVRAVVRTGIHFGCDVFAVYEGYEGLLRGgkYLKKMAWEDVRGWLSEGGTLIGTARSMEFRKR 285
Cdd:cd00763    1 KRIGVLTSGGDAPGMNAAIRGVVRSAIAEGLEVYGIRDGYAGLIAG--DIVPLDRYSVSDIINRGGTFLGSARFPEFKDE 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285812431 286 EGRRQAAGNLISQGIDALVVCGGDGSLTGA-DLFRHEWPSlvdelvaegrftkeevapyknlsiVGLVGSIDNDMSGTDS 364
Cdd:cd00763   79 EGQAKAIEQLKKHGIDALVVIGGDGSYMGAmRLTEHGFPC------------------------VGLPGTIDNDIPGTDY 134
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285812431 365 TIGAYSALERICEMVDYIDATAKSHSRAFVVEVMGRHCGWLALMAGIATGADYIFIPERAVPhgkwQDELKEVCQRHRSK 444
Cdd:cd00763  135 TIGFDTALNTVVEAIDRIRDTSSSHQRISVVEVMGRHCGDIALAAGIAGGAEFIVIPEAEFD----REEVANRIKAGIER 210
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285812431 445 GRRNNTIIVAEGALD-DQLnpvtANDVKDAlieLGLDTKVTILGHVQRGGTAVAHDRWLATLQGVDAVKAVLEftpETPS 523
Cdd:cd00763  211 GKKHAIVVVAEGVYDvDEL----AKEIEEA---TGFETRATVLGHIQRGGSPTAFDRILASRMGAYAVELLLA---GKGG 280
                        330       340       350
                 ....*....|....*....|....*....|....*....
gi 285812431 524 PLIGILENKIIRMPLVEsvkltksvatAIEN-KDFDKAI 561
Cdd:cd00763  281 LAVGIQNEQLVHHDIID----------AIENmKPFKKDW 309
PFK_mixed TIGR02483
phosphofructokinase; Members of this family that are characterized, save one, are ...
207-542 2.49e-79

phosphofructokinase; Members of this family that are characterized, save one, are phosphofructokinases dependent on pyrophosphate (EC 2.7.1.90) rather than ATP (EC 2.7.1.11). The exception is one of three phosphofructokinases from Streptomyces coelicolor. Family members are both bacterial and archaeal. [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 274155 [Multi-domain]  Cd Length: 324  Bit Score: 261.47  E-value: 2.49e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285812431  207 KIAVMTSGGDSPGMNAAVRAVVRTGIH-FGCDVFAVYEGYEGLLRGgKYLKKMAWEDVRGWLSEGGTLIGTARSMEFRK- 284
Cdd:TIGR02483   1 RIGVLTGGGDCPGLNAVIRGVVRRAIAeYGWEVIGIRDGWRGLLEG-DTVPLLDLEDVRGILPRGGTILGSSRTNPFKYe 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285812431  285 REGRRQAAGNLISQGIDALVVCGGDGSLTGAdlfrhewpslvdelvaeGRFTKeevapyKNLSIVGLVGSIDNDMSGTDS 364
Cdd:TIGR02483  80 EDGDDKIVANLKELGLDALIAIGGDGTLGIA-----------------RRLAD------KGLPVVGVPKTIDNDLEATDY 136
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285812431  365 TIGAYSALERICEMVDYIDATAKSHSRAFVVEVMGRHCGWLALMAGIATGADYIFIPERavpHGKWQDELKEVCQRhRSK 444
Cdd:TIGR02483 137 TFGFDTAVEIATEALDRLHTTAESHHRVMVVEVMGRHAGWIALHSGIAGGADVILIPEI---PFDIDSVCEKVRER-FAR 212
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285812431  445 GRRNNTIIVAEGALDDQLNPVTANDVKDA---------------LIE--LGLDTKVTILGHVQRGGTAVAHDRWLATLQG 507
Cdd:TIGR02483 213 GKRFAIVVVAEGAKPKGGEMVVQEGVKDAfghvrlggignwlaeEIErrTGIETRATVLGHLQRGGSPSAFDRVLATRFG 292
                         330       340       350
                  ....*....|....*....|....*....|....*
gi 285812431  508 VDAVKAVLEFTPETPSPLIGileNKIIRMPLVESV 542
Cdd:TIGR02483 293 VAAVDLVHEGQFGHMVALRG---TDIVYVPIAEAV 324
PRK14071 PRK14071
ATP-dependent 6-phosphofructokinase;
204-511 2.11e-52

ATP-dependent 6-phosphofructokinase;


Pssm-ID: 184487 [Multi-domain]  Cd Length: 360  Bit Score: 187.97  E-value: 2.11e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285812431 204 KKKKIAVMTSGGDSPGMNAAVRAVVRTGI-HFGCDVFAVYEGYEGLL-RGGKYLKkMAWEDVRGWLSEGGTLIGTA---- 277
Cdd:PRK14071   3 EKKRIGILTSGGDCAGLNAVIRAVVHRARgTYGWEVIGIRDATQGLMaRPPQYIE-LDLDQVDDLLRMGGTILGTTnkgd 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285812431 278 -------------RSMEFRkrEGRRQAagnlisqGIDALVVCGGDGSLtgadlfrhewpSLVDELVAEGrftkeevapyk 344
Cdd:PRK14071  82 pfafpmpdgslrdRSQEII--DGYHSL-------GLDALIGIGGDGSL-----------AILRRLAQQG----------- 130
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285812431 345 NLSIVGLVGSIDNDMSGTDSTIGAYSALERICEMVDYIDATAKSHSRAFVVEVMGRHCGWLALMAGIATGADYIFIPEra 424
Cdd:PRK14071 131 GINLVGIPKTIDNDVGATEVSIGFDTAVNIATEALDRLHFTAASHNRVMILEVMGRDAGHIALAAGIAGGADVILIPE-- 208
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285812431 425 VPHgKWQDELKEVCQRhRSKGRRNNTIIVAEGALDDQLNPVT-----------------ANDVKDAlieLGLDTKVTILG 487
Cdd:PRK14071 209 IPY-TLENVCKKIRER-QEEGKNFCLVVVSEAVRTEEGEQVTktqalgedryggigqylAEQIAER---TGAETRVTVLG 283
                        330       340
                 ....*....|....*....|....
gi 285812431 488 HVQRGGTAVAHDRWLATLQGVDAV 511
Cdd:PRK14071 284 HIQRGGIPSPRDRLLASAFGVAAV 307
6PF1K_euk TIGR02478
6-phosphofructokinase, eukaryotic type; Members of this family are eukaryotic (with one ...
196-524 7.91e-49

6-phosphofructokinase, eukaryotic type; Members of this family are eukaryotic (with one exception) ATP-dependent 6-phosphofructokinases (EC 2.7.1.11) in which two tandem copies of the phosphofructokinase are found. Members are found, often including several isozymes, in animals and fungi and in the bacterium Propionibacterium acnes KPA171202 (a human skin commensal).


Pssm-ID: 274152 [Multi-domain]  Cd Length: 746  Bit Score: 186.01  E-value: 7.91e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285812431  196 RQTLGSSQKKKKIAVMTSGGDSPGMNAAVRAVVRTGIHFGCDVFAVYEGYEGLLRGGkyLKKMAWEDVRGWLSEGGTLIG 275
Cdd:TIGR02478 380 KKLVPSEASRLRIAIIHVGAPAGGMNAATRSAVRYALARGHTVIAIHNGFSGLARHD--VRELTWSDVEGWVGEGGSELG 457
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285812431  276 TARSMEFRKREgrrQAAGNLISQGIDALVVCGGDGSLTGA---DLFRHEWPSLvdelvaegrftkeevapykNLSIVGLV 352
Cdd:TIGR02478 458 TNRSLPGDDLG---TIAYYFQQHKIDGLIIIGGFEAFEALyqlDAAREKYPAF-------------------RIPMVVIP 515
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285812431  353 GSIDNDMSGTDSTIGAYSALERICEMVDYIDATAK-SHSRAFVVEVMGRHCGWLALMAGIATGADYIFIPERAVPHGKWQ 431
Cdd:TIGR02478 516 ATISNNVPGTEYSLGSDTALNEITEYCDNIKQSASaSKRRVFVVETMGGYSGYLATMAGLATGADAAYIPEEGISLKDLQ 595
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285812431  432 ---DELKEVCQRHRSKGrrnnTIIVAEGALDDqlnpVTANDVKDALIELG---LDTKVTILGHVQRGGTAVAHDRWLATL 505
Cdd:TIGR02478 596 ediEHLKETFAEGRAGK----LILRNEKASKV----YTTDFIARIISEEGkgrFDARTAVLGHMQQGGSPSPFDRVRATR 667
                         330
                  ....*....|....*....
gi 285812431  506 QGVDAVKAVLEFTPETPSP 524
Cdd:TIGR02478 668 LAIRAVDFIEEKIKANKHA 686
PfkA COG0205
6-phosphofructokinase [Carbohydrate transport and metabolism]; 6-phosphofructokinase is part ...
616-887 1.80e-43

6-phosphofructokinase [Carbohydrate transport and metabolism]; 6-phosphofructokinase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 439975 [Multi-domain]  Cd Length: 344  Bit Score: 161.40  E-value: 1.80e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285812431 616 TLYCLSHGHKPYAIMNGFSGLIqTGEVKELSWIDVENWHNLGGSEIGTNRS---VASEDLGTIAYYFQKNKLDGLIILGG 692
Cdd:COG0205   24 VRTAIKYGIEVYGIRDGYEGLL-EGDIIDLTREDVSGILQRGGTILGSSRSkpfKTEEGREKALENLKKLGIDALVVIGG 102
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285812431 693 fEG-FRSLKQLRDgrtqhpIFNIPMCLIPATVSNNVPGTEYSLGVDTCLNALVNYTDDIKQSASATrRRVFVCEVQGGHS 771
Cdd:COG0205  103 -DGsLDGAAKLAE------EYGIPVVGIPKTIDNDLPGTDYTIGFDTAVNTAAEAIDRLRDTAASH-ERVFVVEVMGRHA 174
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285812431 772 GYIASFTGLITGAVSVYTPEKKIDLASIREDItllKENFRHDKG----------ENRNGKLLVRNEQASSVY-----STQ 836
Cdd:COG0205  175 GWLALAAGLAGGADLILIPEVPFDLDKLLEKL---KERRKRGKGysiivvaegaGDEDGEAVLEADTDAFGHvrlggIGE 251
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 285812431 837 LLADIISEASKGKfgVRTAIPGHVQQGGVPSSKDRVTASRFAVKCIKFIEQ 887
Cdd:COG0205  252 YLAKEIEERTGIE--TRVTVLGHLQRGGSPSAFDRVLASRLGAAAVELLLE 300
PRK03202 PRK03202
ATP-dependent 6-phosphofructokinase;
618-887 2.93e-39

ATP-dependent 6-phosphofructokinase;


Pssm-ID: 235111 [Multi-domain]  Cd Length: 320  Bit Score: 148.69  E-value: 2.93e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285812431 618 YCLSHGHKPYAIMNGFSGLIQtGEVKELSWIDVENWHNLGGSEIGTNRSVASEDLGT---IAYYFQKNKLDGLIILGGfE 694
Cdd:PRK03202  26 TAISEGLEVYGIYDGYAGLLE-GDIVKLDLKSVSDIINRGGTILGSARFPEFKDEEGrakAIENLKKLGIDALVVIGG-D 103
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285812431 695 G-FRSLKQLRDGrtqhpifNIPMCLIPATVSNNVPGTEYSLGVDTCLNALVNYTDDIKQSASAtRRRVFVCEVQGGHSGY 773
Cdd:PRK03202 104 GsYMGAKRLTEH-------GIPVIGLPGTIDNDIAGTDYTIGFDTALNTAVEAIDRLRDTASS-HERVFIVEVMGRHAGD 175
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285812431 774 IASFTGLITGAVSVYTPEKKIDLASIREDItllKENFRHDKgenRNGKLLVrneqASSVYSTQLLADIISEasKGKFGVR 853
Cdd:PRK03202 176 LALHAGIAGGAEVILIPEVPFDIEELCAKI---KKGRERGK---KHAIIVV----AEGVMPAEELAKEIEE--RTGLETR 243
                        250       260       270
                 ....*....|....*....|....*....|....
gi 285812431 854 TAIPGHVQQGGVPSSKDRVTASRFAVKCIKFIEQ 887
Cdd:PRK03202 244 VTVLGHIQRGGSPTAFDRVLASRMGAHAVELLLE 277
Pfk_N pfam18468
Phosphofructokinase N-terminal domain yeast; This is a phosphofructokinase (Pfk) N-terminal ...
8-101 1.79e-31

Phosphofructokinase N-terminal domain yeast; This is a phosphofructokinase (Pfk) N-terminal domain found in yeast ATP-dependent 6-phosphofructokinase subunit alpha. ATP-dependent 6-phosphofructokinases (Pfks, EC 2.7.1.11) catalyze the phosphorylation of fructose 6-phosphate (F-6-P) to fructose 1,6-bisphosphate, a key control step of glycolysis in most organizms. The N-terminal domain contains the active site and is related to glyoxalase I (E.C. 4.4.1.5).


Pssm-ID: 408261  Cd Length: 98  Bit Score: 118.40  E-value: 1.79e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285812431    8 YGVAFRSIITNDEALFKKTIHFYHTLGFATVKDFNKFKHGENSLLssGTSQDSLREVWLESFKLSEVDASGFRIPQQEAT 87
Cdd:pfam18468   1 SGLSFISFVTNDPDKFEATIKFYTKLGFSATKSYSKDTNNDFELI--GVSTDSIKEIWLESFPLSEVDSHGFRIPWQESP 78
                          90       100
                  ....*....|....*....|
gi 285812431   88 N------KAQSQGALLKIRL 101
Cdd:pfam18468  79 GyqgdysPKLSDGVVIKLRL 98
Bacterial_PFK cd00763
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ...
620-878 8.35e-31

Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent phosphofructokinases. These are allosrterically regulated homotetramers; the subunits are of about 320 amino acids.


Pssm-ID: 238388 [Multi-domain]  Cd Length: 317  Bit Score: 124.06  E-value: 8.35e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285812431 620 LSHGHKPYAIMNGFSGLIQtGEVKELSWIDVENWHNLGGSEIGTNRS--VASEDLGTIAY-YFQKNKLDGLIILGGFEGF 696
Cdd:cd00763   27 IAEGLEVYGIRDGYAGLIA-GDIVPLDRYSVSDIINRGGTFLGSARFpeFKDEEGQAKAIeQLKKHGIDALVVIGGDGSY 105
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285812431 697 RSLKQLrdgrTQHpifNIPMCLIPATVSNNVPGTEYSLGVDTCLNALVNYTDDIKQSASaTRRRVFVCEVQGGHSGYIAS 776
Cdd:cd00763  106 MGAMRL----TEH---GFPCVGLPGTIDNDIPGTDYTIGFDTALNTVVEAIDRIRDTSS-SHQRISVVEVMGRHCGDIAL 177
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285812431 777 FTGLITGAVSVYTPEKKIDLASIREDITLLkenfrHDKGEnRNGKLLVrneqASSVYSTQLLADIISEasKGKFGVRTAI 856
Cdd:cd00763  178 AAGIAGGAEFIVIPEAEFDREEVANRIKAG-----IERGK-KHAIVVV----AEGVYDVDELAKEIEE--ATGFETRATV 245
                        250       260
                 ....*....|....*....|..
gi 285812431 857 PGHVQQGGVPSSKDRVTASRFA 878
Cdd:cd00763  246 LGHIQRGGSPTAFDRILASRMG 267
PFK cd00363
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ...
594-879 1.91e-30

Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases. Some members evolved by gene duplication and thus have a large C-terminal/N-terminal extension comprising a second PFK domain. Generally, ATP-PFKs are allosteric homotetramers, and PPi-PFKs are dimeric and nonallosteric except for plant PPi-PFKs which are allosteric heterotetramers.


Pssm-ID: 238216 [Multi-domain]  Cd Length: 338  Bit Score: 123.56  E-value: 1.91e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285812431 594 LNIGIVHVGAPSAALNAATRAATLYCLSHGHKPYAIMNGFSGLIQtGEVKELSWIDVENWHNLGGSEIGTNRSVASED-- 671
Cdd:cd00363    1 KKIGVLTSGGDAPGMNAAIRGVVRSAIAEGLEVYGIYEGYAGLVE-GDIKELDWESVSDIINRGGTIIGSARCKEFRTee 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285812431 672 -LGTIAYYFQKNKLDGLIILGGFEGFRSLKQLRDGRTQHPIfNIPMCLIPATVSNNVPGTEYSLGVDTCLNALVNYTDDI 750
Cdd:cd00363   80 gRAKAAENLKKHGIDALVVIGGDGSYTGADLLTEEWPSKYQ-GFNVIGLPGTIDNDIKGTDYTIGFDTALKTIVEAIDRI 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285812431 751 KQSASaTRRRVFVCEVQGGHSGYIASFTGLITGAVSVYTPEKKIDLASIREDITLLKEnfRHDKGEnRNGKLLVRN---E 827
Cdd:cd00363  159 RDTAS-SHQRTFVVEVMGRHCGDIALEAGLATGADIIFIPEEPAADEWEEEMVDVIKK--RRERGK-RHGIVIVAEgaiD 234
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 285812431 828 QASSVYSTQLLADIISEasKGKFGVRTAIPGHVQQGGVPSSKDRVTASRFAV 879
Cdd:cd00363  235 FIPKPITEKLLAKLVEE--RLGFDTRATVLGHVQRGGTPTAFDRILASRLGA 284
PTZ00286 PTZ00286
6-phospho-1-fructokinase; Provisional
204-473 7.64e-25

6-phospho-1-fructokinase; Provisional


Pssm-ID: 185539  Cd Length: 459  Bit Score: 108.98  E-value: 7.64e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285812431 204 KKKKIAVMTSGGDSPGMNAAVRAVVRTGIH-FGC-DVFAVYEGYEGLLRGGKYlkKMAWEDVRGWLSEGGTLIGTARSME 281
Cdd:PTZ00286  86 KEVKAGIVTCGGLCPGLNVVIRELVMNLINnYGVkTIYGAKYGYKGLYKEDWI--KLDPKDVKTIHRLGGTILGSSRGGF 163
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285812431 282 FRKregrrQAAGNLISQGIDALVVCGGDGSLTGADlfrhewpslvdELVAEGRFTKEevapykNLSIVGLVGSIDNDMSG 361
Cdd:PTZ00286 164 DPK-----VMVDTLIRHGINILFTLGGDGTHRGAL-----------AIYKELRRRKL------NISVVGIPKTIDNDIPI 221
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285812431 362 TDSTIGAYSALERICEMVDYIDATAKSHSRAF-VVEVMGRHCGWLALMAGIATG-ADYIFIPERAVPhgkwqdeLKEVCQ 439
Cdd:PTZ00286 222 IDESFGFQTAVEEAQNAIRAAYVEAKSAKNGVgIVKLMGRDSGFIALHASVASAdVNVCLIPEFDIP-------LEGVLE 294
                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 285812431 440 --RHRSKGRRNNTIIVAEGALDDQLnPVTANDVKDA 473
Cdd:PTZ00286 295 yiEQRLQKKGHCVIVVAEGAGQSLK-DADLDLGTDA 329
PRK14071 PRK14071
ATP-dependent 6-phosphofructokinase;
622-887 2.05e-21

ATP-dependent 6-phosphofructokinase;


Pssm-ID: 184487 [Multi-domain]  Cd Length: 360  Bit Score: 97.06  E-value: 2.05e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285812431 622 HGHKPYAIMNGFSGLIQTG-EVKELSWIDVENWHNLGGSEIGT-NR-----------SVASEDLGTIAYYFQKNkLDGLI 688
Cdd:PRK14071  34 YGWEVIGIRDATQGLMARPpQYIELDLDQVDDLLRMGGTILGTtNKgdpfafpmpdgSLRDRSQEIIDGYHSLG-LDALI 112
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285812431 689 ILGGFEGFRSLKQLRDgrtqhpIFNIPMCLIPATVSNNVPGTEYSLGVDTCLNALVNYTDDIKQSAsATRRRVFVCEVQG 768
Cdd:PRK14071 113 GIGGDGSLAILRRLAQ------QGGINLVGIPKTIDNDVGATEVSIGFDTAVNIATEALDRLHFTA-ASHNRVMILEVMG 185
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285812431 769 GHSGYIASFTGLITGAVSVYTPEKKIDLASIREDItllkenfRHDKGENRNGKLL-----VRNEQASSVYST-------- 835
Cdd:PRK14071 186 RDAGHIALAAGIAGGADVILIPEIPYTLENVCKKI-------RERQEEGKNFCLVvvseaVRTEEGEQVTKTqalgedry 258
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 285812431 836 ----QLLADIISEASKGKfgVRTAIPGHVQQGGVPSSKDRVTASRFAVKCIKFIEQ 887
Cdd:PRK14071 259 ggigQYLAEQIAERTGAE--TRVTVLGHIQRGGIPSPRDRLLASAFGVAAVDLIAQ 312
PLN02884 PLN02884
6-phosphofructokinase
207-548 4.40e-19

6-phosphofructokinase


Pssm-ID: 178472 [Multi-domain]  Cd Length: 411  Bit Score: 91.03  E-value: 4.40e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285812431 207 KIAVMTSGGDSPGMNAAVRAVVRTGIHFGC-DVFAVYEGYEGLLRGGKYLKKMAWEDVRGWLSEGGTLIGTAR------- 278
Cdd:PLN02884  55 KAAIVTCGGLCPGLNDVIRQIVFTLEIYGVkNIVGIPFGYRGFFEKGLSEMPLSRKVVQNIHLSGGSLLGVSRggaktsd 134
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285812431 279 ---SMEFRkregrrqaagnlisqGIDALVVCGGDGSLTGADLFrHEwpslvdelvaEGRFTKEEVapyknlSIVGLVGSI 355
Cdd:PLN02884 135 ivdSIEAR---------------GINMLFVLGGNGTHAGANAI-HN----------ECRKRKMKV------SVVGVPKTI 182
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285812431 356 DNDMSGTDSTIGAYSALERICEMVD--YIDATAKSHSRAfVVEVMGRHCGWLALMAGIATG-ADYIFIPERAV----PHG 428
Cdd:PLN02884 183 DNDILLMDKTFGFDTAVEEAQRAINsaYIEAHSAYHGIG-LVKLMGRSSGFIAMHASLASGqVDICLIPEVPFtldgPNG 261
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285812431 429 KWQdELKEVCQrhrSKGRrnNTIIVAEGALDDQLNPVTAND-----------------VKDALIELGL--DTKVTILGHV 489
Cdd:PLN02884 262 VLR-HLEHLIE---TKGS--AVVCVAEGAGQDLLQKTNATDasgnpvlgdigvhlqqeIKKHFKDIGVpaDVKYIDPTYM 335
                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 285812431 490 QRGGTAVAHDRWLATLQGVDAVKAVLE-FTPETpsplIGILENKIIRMPLVESVKLTKSV 548
Cdd:PLN02884 336 IRACRANASDAILCTVLGQNAVHGAFAgFSGIT----VGICNTHYVYLPIPEVIAYPRRV 391
PRK06555 PRK06555
pyrophosphate--fructose-6-phosphate 1-phosphotransferase; Validated
205-457 1.62e-18

pyrophosphate--fructose-6-phosphate 1-phosphotransferase; Validated


Pssm-ID: 180620 [Multi-domain]  Cd Length: 403  Bit Score: 88.91  E-value: 1.62e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285812431 205 KKKIAVMTSGGDSPGMNAAVRAVVR--TGIHFGCDVFAVYEGYEGLLRGGKYLKKmawEDVRG----WLSEGGTLIGTAR 278
Cdd:PRK06555   3 VKKVALLTAGGLAPCLSSAVGGLIEryTEIAPEVEIIAYRSGYQGLLLGDSIEIT---PAVRAnaglLHRYGGSPIGNSR 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285812431 279 -----SMEFRKR----EGR---RQAAGNLISQGIDALVVCGGDGS-LTGADLFRHewpslvdeLVAEGrftkeevapYkN 345
Cdd:PRK06555  80 vkltnVADCVKRglvkEGEnplKVAAERLAADGVDILHTIGGDDTnTTAADLAAY--------LAENG---------Y-D 141
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285812431 346 LSIVGLVGSIDNDMSGTDSTIGAYSALERICEMVDYIDATAKSHSRAFVV-EVMGRHCGWLAlmagIATGADY------- 417
Cdd:PRK06555 142 LTVVGLPKTIDNDVVPIRQSLGAWTAAEQGARFFDNVINEHSANPRMLIIhEVMGRNCGWLT----AATARAYrewldrq 217
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 285812431 418 -----------------IFIPERAVPHGKWQDELKEVCQRHrskgrRNNTIIVAEGA 457
Cdd:PRK06555 218 eyvpgfglsaerwdihaVYLPEMAFDLEAEAERLKAVMDEV-----GNVNIFLSEGA 269
PRK14072 PRK14072
diphosphate--fructose-6-phosphate 1-phosphotransferase;
355-495 2.09e-15

diphosphate--fructose-6-phosphate 1-phosphotransferase;


Pssm-ID: 237600 [Multi-domain]  Cd Length: 416  Bit Score: 79.52  E-value: 2.09e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285812431 355 IDNDMSGTDSTIGAYSALERICE--MVDYIDATA-KSHSRAFVVEVMGRHCGWLALMAGIAT-----GADYIFIPERAVP 426
Cdd:PRK14072 142 IDNDLPGTDHCPGFGSAAKYIATsvLEAALDVAAmANTSKVFILEVMGRHAGWLAAAAALAKqnpddAPHLIYLPERPFD 221
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285812431 427 HGKWQDELKEVCQRHrskGRrnNTIIVAEGALDDQLNPVT-ANDVKDAlielgldtkvtiLGHVQRGGTA 495
Cdd:PRK14072 222 EEKFLADVRAIVKRY---GY--CVVVVSEGIRDADGKFIAeAGLAEDA------------FGHAQLGGVA 274
PRK06830 PRK06830
ATP-dependent 6-phosphofructokinase;
204-457 2.35e-14

ATP-dependent 6-phosphofructokinase;


Pssm-ID: 235869  Cd Length: 443  Bit Score: 76.45  E-value: 2.35e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285812431 204 KKKKIAVMTSGGDSPGMNAAVRAVVRTgIHFGCDVFAVY---EGYEGLL-RGGKYLKKMAWEDVRGWLSEGGTLIGTARS 279
Cdd:PRK06830  79 SKVKAAIVTCGGLCPGLNDVIRAIVLE-LHHHYGVRRILgirYGYQGLIpRYGHDPVELTPEVVADIHEFGGTILGSSRG 157
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285812431 280 MefrkregrrQAAG----NLISQGIDALVVCGGDGSLTGADlfrhewpSLVDELVAEGRftkeevapykNLSIVGLVGSI 355
Cdd:PRK06830 158 P---------QDPEeivdTLERMNINILFVIGGDGTLRGAS-------AIAEEIERRGL----------KISVIGIPKTI 211
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285812431 356 DNDMSGTDSTIGAYSALERICEmvdyidATAKSHSRAF-------VVEVMGRHCGWLALMAGIATG-ADYIFIPEraVP- 426
Cdd:PRK06830 212 DNDINFIQKSFGFETAVEKATE------AIRCAHVEANgapngigLVKLMGRHSGFIAAYAALASKdVNFVLIPE--VPf 283
                        250       260       270
                 ....*....|....*....|....*....|...
gi 285812431 427 --HGkwQDELKEVCQRhRSKGRRNNTIIVAEGA 457
Cdd:PRK06830 284 dlEG--PNGLLAALEK-RLAERGHAVIVVAEGA 313
PTZ00286 PTZ00286
6-phospho-1-fructokinase; Provisional
627-803 9.03e-12

6-phospho-1-fructokinase; Provisional


Pssm-ID: 185539  Cd Length: 459  Bit Score: 68.53  E-value: 9.03e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285812431 627 YAIMNGFSGLIQTGEVKeLSWIDVENWHNLGGSEIGTNRSvaSEDLGTIAYYFQKNKLDGLIILGGFEGFRS----LKQL 702
Cdd:PTZ00286 123 YGAKYGYKGLYKEDWIK-LDPKDVKTIHRLGGTILGSSRG--GFDPKVMVDTLIRHGINILFTLGGDGTHRGalaiYKEL 199
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285812431 703 RdgRTQHpifNIPMCLIPATVSNNVPGTEYSLGVDTCLNALVNYTDDIKQSASATRRRVFVCEVQGGHSGYIASFTGLIT 782
Cdd:PTZ00286 200 R--RRKL---NISVVGIPKTIDNDIPIIDESFGFQTAVEEAQNAIRAAYVEAKSAKNGVGIVKLMGRDSGFIALHASVAS 274
                        170       180
                 ....*....|....*....|..
gi 285812431 783 GAVSV-YTPEKKIDLASIREDI 803
Cdd:PTZ00286 275 ADVNVcLIPEFDIPLEGVLEYI 296
PLN02564 PLN02564
6-phosphofructokinase
207-479 5.01e-10

6-phosphofructokinase


Pssm-ID: 178178  Cd Length: 484  Bit Score: 63.23  E-value: 5.01e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285812431 207 KIAVMTSGGDSPGMNAAVRAVVrTGIHFGCDVFAVYeGYEGLLRG--GKYLKKMAWEDVRGWLSEGGTLIGTARSMEFRK 284
Cdd:PLN02564  89 RACIVTCGGLCPGLNTVIREIV-CGLSYMYGVTRIL-GIDGGYRGfySRNTIPLTPKVVNDIHKRGGTILGTSRGGHDTS 166
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285812431 285 RegrrqAAGNLISQGIDALVVCGGDGSLTGADLFRHEwpslvdelvAEGRFTKEEVApyknlsivGLVGSIDNDMSGTDS 364
Cdd:PLN02564 167 K-----IVDSIQDRGINQVYIIGGDGTQKGASVIYEE---------IRRRGLKVAVA--------GIPKTIDNDIPVIDK 224
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285812431 365 TIGAYSALERICEMVDYIDATAKS-HSRAFVVEVMGRHCGWLALMAGIAT-GADYIFIPEraVP---HGKwqDELKEVCQ 439
Cdd:PLN02564 225 SFGFDTAVEEAQRAINAAHVEAESvENGIGLVKLMGRYSGFIAMYATLASrDVDCCLIPE--SPfylEGK--GGLFEFIE 300
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 285812431 440 RhRSKGRRNNTIIVAEGALDDQL-NPVTANDVKDA-----LIELGL 479
Cdd:PLN02564 301 K-RLKENGHMVIVVAEGAGQDLIaESMESSDLQDAsgnklLLDVGL 345
Pyrophosphate_PFK cd00765
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ...
201-482 5.17e-06

Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include pyrophosphate-dependent phosphofructokinases. These are found in bacteria as well as plants. These may be dimeric nonallosteric enzymes as in bacteria or allosteric heterotetramers as in plants.


Pssm-ID: 238390  Cd Length: 550  Bit Score: 50.25  E-value: 5.17e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285812431 201 SSQKKKKIAVMTSGGDSPGMNAAVRAVVrTGI---HFGCDVFAVYEGYEGLLRgGKYLKKMAwEDVRGWLSEGG-TLIGT 276
Cdd:cd00765   68 SSAPKLKIGIVLSGGQAPGGHNVISGLF-DYLkerAKGSTLYGFKGGPAGILK-CDYIELNA-EYIQPYRNTGGfDMICS 144
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285812431 277 ARSmEFRKREGRRQAAGNLISQGIDALVVCGGDGSLTGADLfrhewpsLVDELVAEGRFTKeevapyknlsIVGLVGSID 356
Cdd:cd00765  145 GRT-KIETEDQFKQAEETAKKLDLDALVVIGGDDSNTNAAL-------LAENFRSKGLKTR----------VIGVPKTID 206
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285812431 357 NDM--SGTDSTIGAYSALERICEMVDYIDATAKSHSRAF-VVEVMGRHCGWLALMAGIATGADYIFIPERAVPHGKW--- 430
Cdd:cd00765  207 GDLknKEIETSFGFDTATKIYSELIGNVMRDARSTGKYWhFVKLMGRSASHIALECALKTHPNICIISEEVSAQKQTlkn 286
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 285812431 431 -QDELKEVCQRHRSKGRRNNTIIVAEG---------ALDDQLNPVTANDVKDaliELGLDTK 482
Cdd:cd00765  287 iTDYMVDVICKRAELGYNFGVVLVPEGliefipevkELIAELNEILANEVVE---FNGLWKK 345
PTZ00468 PTZ00468
phosphofructokinase family protein; Provisional
173-459 5.25e-06

phosphofructokinase family protein; Provisional


Pssm-ID: 185647 [Multi-domain]  Cd Length: 1328  Bit Score: 50.74  E-value: 5.25e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285812431  173 AFLEATSEDEIIS-RASSDASdllrqtlgSSQKK---KKIAVMTSGGDSPGMNAAVrAVVRTGIHFgCD----VFAVYEG 244
Cdd:PTZ00468   74 SYFPLTSGNSLVKfEAISDGS--------SSWKKfpaRRIGVVLSGGQASGGHNVI-AGLMSYIKL-CNqssqLFGFLGG 143
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285812431  245 YEGLLrgGKYLKKMAWEDVRGWLSEGG-TLIGTARSMefRKREGRRQAAGNLISQ-GIDALVVCGGDGSLTGAdlfrhew 322
Cdd:PTZ00468  144 PEGVY--SERYRELTEDDINGILNQGGfNIICSGRHK--IETEEQMRASLEICEKlKLHGLVVIGGDDSNTNA------- 212
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285812431  323 pslvdELVAEgRFTKEEvapyKNLSIVGLVGSIDNDMSG--TDSTIGAYSALERICEMVDYI-DATAKSHSRAFVVEVMG 399
Cdd:PTZ00468  213 -----AVLAE-YFKRNS----SSTVVVGCPKTIDGDLKNevIETSFGYDTAVKTYSEQIGSImDAIKTEGYGYYFVRLMG 282
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 285812431  400 RHCGWLALMAGIATGADYIFIPERAVPHGKWQ----DELKEVCQRHRSKGRRNNTIIVAEGALD 459
Cdd:PTZ00468  283 RSASHITLECGLQTRANMILIGEEIKEENRSLmsivDEIVEMILKRDSLGKKHGIVLLPEGLIE 346
PRK07085 PRK07085
diphosphate--fructose-6-phosphate 1-phosphotransferase; Provisional
201-456 1.81e-03

diphosphate--fructose-6-phosphate 1-phosphotransferase; Provisional


Pssm-ID: 235930  Cd Length: 555  Bit Score: 42.22  E-value: 1.81e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285812431 201 SSQKKKKIAVMTSGGDSPG-------MNAAVRAvvrtgIHFGCDVFAVYEGYEGLLRGgKY--LKKMAWEDVRgwlSEGG 271
Cdd:PRK07085  66 SSSKPLKVGVILSGGQAPGghnviagLFDGLKK-----LNPDSKLFGFIGGPLGLLNG-KYieITEEVIDEYR---NTGG 136
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285812431 272 -TLIGTARSmEFRKREGRRQAAGNLISQGIDALVVCGGDGSLTGAdlfrhewpslvdELVAEgRFTKEEVapykNLSIVG 350
Cdd:PRK07085 137 fDMIGSGRT-KIETEEQKEACLETVKKLKLDGLVIIGGDDSNTNA------------AILAE-YFAKHGC----KTQVIG 198
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285812431 351 LVGSIDNDMSGT--DSTIGAYSALERICEMVDYI--DA-TAKSHSraFVVEVMGRHCGWLALMAGIATGADYIFIPERAV 425
Cdd:PRK07085 199 VPKTIDGDLKNEfiETSFGFDTATKTYSEMIGNIsrDAlSAKKYW--HFIKLMGRSASHIALECALQTHPNICLISEEVA 276
                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 285812431 426 PHGKWQDELKE-----VCQRhRSKGRRNNTIIVAEG 456
Cdd:PRK07085 277 EKKMSLQDIVHyiasvIADR-AAKGKNYGVILIPEG 311
PRK14072 PRK14072
diphosphate--fructose-6-phosphate 1-phosphotransferase;
719-861 3.72e-03

diphosphate--fructose-6-phosphate 1-phosphotransferase;


Pssm-ID: 237600 [Multi-domain]  Cd Length: 416  Bit Score: 41.00  E-value: 3.72e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285812431 719 IPATVSNNVPGTEYSLG--------VDTCLNAlvnYTDdikQSASATRRRVFVCEVQGGHSGYIASFTGLIT-----GAV 785
Cdd:PRK14072 138 IPKTIDNDLPGTDHCPGfgsaakyiATSVLEA---ALD---VAAMANTSKVFILEVMGRHAGWLAAAAALAKqnpddAPH 211
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285812431 786 SVYTPEKKIDLASIREDI-TLLKENFR---------HDKgenrNGKLLVRNEQASSVYS-TQL--LADIISEASKGKFG- 851
Cdd:PRK14072 212 LIYLPERPFDEEKFLADVrAIVKRYGYcvvvvsegiRDA----DGKFIAEAGLAEDAFGhAQLggVAPVLANLIKEKLGk 287
                        170
                 ....*....|.
gi 285812431 852 -VRTAIPGHVQ 861
Cdd:PRK14072 288 kVHWAVLDYLQ 298
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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