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Conserved domains on  [gi|285813127|tpg|DAA09024|]
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TPA: Hsk3p [Saccharomyces cerevisiae S288C]

Protein Classification

DASH complex subunit HSK3 family protein( domain architecture ID 10548802)

DASH complex subunit HSK3 is a component of the DASH complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation

Gene Ontology:  GO:0051301|GO:0045787

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DASH_Hsk3 pfam08227
DASH complex subunit Hsk3 like; The DASH complex is a ~10 subunit microtubule-binding complex ...
 6-52 1.02e-12

DASH complex subunit Hsk3 like; The DASH complex is a ~10 subunit microtubule-binding complex that is transferred to the kinetochore prior to mitosis. In Saccharomyces cerevisiae DASH forms both rings and spiral structures on microtubules in vitro. This family also includes several higher eukaryotic proteins. However, other DASH subunits do not appear to be conserved in higher eukaryotes.


:

Pssm-ID: 429874 [Multi-domain]  Cd Length: 45  Bit Score: 56.03  E-value: 1.02e-12
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 285813127   6 QRQYNQLAHELRELQTNLQETTKQLDIMSKQCNEnlVGQLGKVHGSW 52
Cdd:pfam08227  1 QRQYSHLASQLAQLQANLADTEELLRMTSEQANS--IRKLGKYHASW 45
 
Name Accession Description Interval E-value
DASH_Hsk3 pfam08227
DASH complex subunit Hsk3 like; The DASH complex is a ~10 subunit microtubule-binding complex ...
 6-52 1.02e-12

DASH complex subunit Hsk3 like; The DASH complex is a ~10 subunit microtubule-binding complex that is transferred to the kinetochore prior to mitosis. In Saccharomyces cerevisiae DASH forms both rings and spiral structures on microtubules in vitro. This family also includes several higher eukaryotic proteins. However, other DASH subunits do not appear to be conserved in higher eukaryotes.


Pssm-ID: 429874 [Multi-domain]  Cd Length: 45  Bit Score: 56.03  E-value: 1.02e-12
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 285813127   6 QRQYNQLAHELRELQTNLQETTKQLDIMSKQCNEnlVGQLGKVHGSW 52
Cdd:pfam08227  1 QRQYSHLASQLAQLQANLADTEELLRMTSEQANS--IRKLGKYHASW 45
 
Name Accession Description Interval E-value
DASH_Hsk3 pfam08227
DASH complex subunit Hsk3 like; The DASH complex is a ~10 subunit microtubule-binding complex ...
 6-52 1.02e-12

DASH complex subunit Hsk3 like; The DASH complex is a ~10 subunit microtubule-binding complex that is transferred to the kinetochore prior to mitosis. In Saccharomyces cerevisiae DASH forms both rings and spiral structures on microtubules in vitro. This family also includes several higher eukaryotic proteins. However, other DASH subunits do not appear to be conserved in higher eukaryotes.


Pssm-ID: 429874 [Multi-domain]  Cd Length: 45  Bit Score: 56.03  E-value: 1.02e-12
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 285813127   6 QRQYNQLAHELRELQTNLQETTKQLDIMSKQCNEnlVGQLGKVHGSW 52
Cdd:pfam08227  1 QRQYSHLASQLAQLQANLADTEELLRMTSEQANS--IRKLGKYHASW 45
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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