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Conserved domains on  [gi|285814498|tpg|DAA10392|]
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TPA: phosphatase regulator [Saccharomyces cerevisiae S288C]

Protein Classification

endosulfine family protein( domain architecture ID 10519919)

endosulfine family protein similar to Saccharomyces cerevisiae mRNA stability protein IGO1 that is required for TORC1 to properly control gene expression and chronological life span

Gene Ontology:  GO:0004864

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Endosulfine pfam04667
cAMP-regulated phosphoprotein/endosulfine conserved region; Conserved region found in both ...
 27-109 2.02e-35

cAMP-regulated phosphoprotein/endosulfine conserved region; Conserved region found in both cAMP-regulated phosphoprotein 19 (ARPP-19) and Alpha/Beta endosulfine. No function has yet been assigned to ARPP-19. Endosulfine is the endogenous ligand for the ATP-dependent potassium (K ATP) channels which occupy a key position in the control of insulin release from the pancreatic beta cell by coupling cell polarity to metabolism. In both cases the region occupies the majority of the protein.


:

Pssm-ID: 398375  Cd Length: 80  Bit Score: 118.18  E-value: 2.02e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285814498   27 DTSKFSPNEMKLYKMYGKLPSKKDIFKHTMQKRKYFDSGDYALQKAGIQNNDpinYGKNNLPLTNPSKLREDIIKRRIST 106
Cdd:pfam04667   1 DLSSLSPEELKLYKKYGKLPKKKDLLSKKLQERKYFDSGDYALSKAGVKKSQ---KSPGGLPSLHPSPERTPHIQRRSSR 77


                  ...
gi 285814498  107 CPS 109
Cdd:pfam04667  78 SAC 80
 
Name Accession Description Interval E-value
Endosulfine pfam04667
cAMP-regulated phosphoprotein/endosulfine conserved region; Conserved region found in both ...
 27-109 2.02e-35

cAMP-regulated phosphoprotein/endosulfine conserved region; Conserved region found in both cAMP-regulated phosphoprotein 19 (ARPP-19) and Alpha/Beta endosulfine. No function has yet been assigned to ARPP-19. Endosulfine is the endogenous ligand for the ATP-dependent potassium (K ATP) channels which occupy a key position in the control of insulin release from the pancreatic beta cell by coupling cell polarity to metabolism. In both cases the region occupies the majority of the protein.


Pssm-ID: 398375  Cd Length: 80  Bit Score: 118.18  E-value: 2.02e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285814498   27 DTSKFSPNEMKLYKMYGKLPSKKDIFKHTMQKRKYFDSGDYALQKAGIQNNDpinYGKNNLPLTNPSKLREDIIKRRIST 106
Cdd:pfam04667   1 DLSSLSPEELKLYKKYGKLPKKKDLLSKKLQERKYFDSGDYALSKAGVKKSQ---KSPGGLPSLHPSPERTPHIQRRSSR 77


                  ...
gi 285814498  107 CPS 109
Cdd:pfam04667  78 SAC 80
 
Name Accession Description Interval E-value
Endosulfine pfam04667
cAMP-regulated phosphoprotein/endosulfine conserved region; Conserved region found in both ...
 27-109 2.02e-35

cAMP-regulated phosphoprotein/endosulfine conserved region; Conserved region found in both cAMP-regulated phosphoprotein 19 (ARPP-19) and Alpha/Beta endosulfine. No function has yet been assigned to ARPP-19. Endosulfine is the endogenous ligand for the ATP-dependent potassium (K ATP) channels which occupy a key position in the control of insulin release from the pancreatic beta cell by coupling cell polarity to metabolism. In both cases the region occupies the majority of the protein.


Pssm-ID: 398375  Cd Length: 80  Bit Score: 118.18  E-value: 2.02e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285814498   27 DTSKFSPNEMKLYKMYGKLPSKKDIFKHTMQKRKYFDSGDYALQKAGIQNNDpinYGKNNLPLTNPSKLREDIIKRRIST 106
Cdd:pfam04667   1 DLSSLSPEELKLYKKYGKLPKKKDLLSKKLQERKYFDSGDYALSKAGVKKSQ---KSPGGLPSLHPSPERTPHIQRRSSR 77


                  ...
gi 285814498  107 CPS 109
Cdd:pfam04667  78 SAC 80
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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