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Conserved domains on  [gi|285815173|tpg|DAA11066|]
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TPA: Rax1p [Saccharomyces cerevisiae S288C]

Protein Classification

regulator of G-protein signaling domain-containing protein( domain architecture ID 10645745)

regulator of G-protein signaling (RGS) domain-containing protein belongs to a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs)

CATH:  1.10.167.10
PubMed:  10203790|10836135|8774882

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RGS smart00315
Regulator of G protein signalling domain; RGS family members are GTPase-activating proteins ...
 189-255 6.37e-08

Regulator of G protein signalling domain; RGS family members are GTPase-activating proteins for heterotrimeric G-protein alpha-subunits.


:

Pssm-ID: 214613  Cd Length: 118  Bit Score: 50.73  E-value: 6.37e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 285815173   189 NTYLVSPEQSERYLSNIPMETRNRIIESVQIERkydiEIFDDLKNLTYQFLEMDCFPKFLSRVALHN 255
Cdd:smart00315  55 DKFLSPNAPKEVNLDSDLREKIEENLESEEPPP----DLFDEAQREVYELLEKDSFPRFLESDYYLR 117
 
Name Accession Description Interval E-value
RGS smart00315
Regulator of G protein signalling domain; RGS family members are GTPase-activating proteins ...
 189-255 6.37e-08

Regulator of G protein signalling domain; RGS family members are GTPase-activating proteins for heterotrimeric G-protein alpha-subunits.


Pssm-ID: 214613  Cd Length: 118  Bit Score: 50.73  E-value: 6.37e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 285815173   189 NTYLVSPEQSERYLSNIPMETRNRIIESVQIERkydiEIFDDLKNLTYQFLEMDCFPKFLSRVALHN 255
Cdd:smart00315  55 DKFLSPNAPKEVNLDSDLREKIEENLESEEPPP----DLFDEAQREVYELLEKDSFPRFLESDYYLR 117
RGS pfam00615
Regulator of G protein signaling domain; RGS family members are GTPase-activating proteins for ...
 188-248 3.25e-03

Regulator of G protein signaling domain; RGS family members are GTPase-activating proteins for heterotrimeric G-protein alpha-subunits.


Pssm-ID: 459870  Cd Length: 117  Bit Score: 37.21  E-value: 3.25e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 285815173  188 CNTYLVSPEQSER----------YLS-------NIPMETRNRIIESvqIERKYDIEIFDDLKNLTYQFLEMDCFPKFL 248
Cdd:pfam00615  34 CEEFKKADPDEERlkkakeiyneFLApgspkeiNLDSDLREEIREN--LEKEPTRDLFDEAQAEVYELMEKDSYPRFL 109
 
Name Accession Description Interval E-value
RGS smart00315
Regulator of G protein signalling domain; RGS family members are GTPase-activating proteins ...
 189-255 6.37e-08

Regulator of G protein signalling domain; RGS family members are GTPase-activating proteins for heterotrimeric G-protein alpha-subunits.


Pssm-ID: 214613  Cd Length: 118  Bit Score: 50.73  E-value: 6.37e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 285815173   189 NTYLVSPEQSERYLSNIPMETRNRIIESVQIERkydiEIFDDLKNLTYQFLEMDCFPKFLSRVALHN 255
Cdd:smart00315  55 DKFLSPNAPKEVNLDSDLREKIEENLESEEPPP----DLFDEAQREVYELLEKDSFPRFLESDYYLR 117
RGS pfam00615
Regulator of G protein signaling domain; RGS family members are GTPase-activating proteins for ...
 188-248 3.25e-03

Regulator of G protein signaling domain; RGS family members are GTPase-activating proteins for heterotrimeric G-protein alpha-subunits.


Pssm-ID: 459870  Cd Length: 117  Bit Score: 37.21  E-value: 3.25e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 285815173  188 CNTYLVSPEQSER----------YLS-------NIPMETRNRIIESvqIERKYDIEIFDDLKNLTYQFLEMDCFPKFL 248
Cdd:pfam00615  34 CEEFKKADPDEERlkkakeiyneFLApgspkeiNLDSDLREEIREN--LEKEPTRDLFDEAQAEVYELMEKDSYPRFL 109
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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