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Conserved domains on  [gi|333469289|gb|EAA10534|]
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AGAP010815-PA, partial [Anopheles gambiae str. PEST]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MG2 super family cl47206
MG2 domain; This is the MG2 (macroglobulin) domain of alpha-2-macroglobulin in eukaryotes. ...
 122-173 6.32e-10

MG2 domain; This is the MG2 (macroglobulin) domain of alpha-2-macroglobulin in eukaryotes. Alpha-2-macroglobulins (A2Ms) are plasma proteins that trap and inhibit a broad range of proteases and are major components of the eukaryotic innate immune system. However, A2M-like proteins were identified in pathogenically invasive bacteria and species that colonize higher eukaryotes. This domain is found in eukaryotic and bacterial proteins. In human A2Ms, this domain is termed macroglobulin-like (MG) domain 2 and in Salmonella enterica ser A2Ms, this is domain 4.


The actual alignment was detected with superfamily member pfam01835:

Pssm-ID: 426464 [Multi-domain]  Cd Length: 95  Bit Score: 53.47  E-value: 6.32e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 333469289  122 SGLIQVDKPVFKPGDTVNFRVIVLDTELKPPARvKSVYVTIRDPQRNVIRKW 173
Cdd:pfam01835   1 RAFVYTDRGIYRPGETVHFKGLLRDQDLRPLAG-LPVTLTVTDPDGNEVRRL 51
 
Name Accession Description Interval E-value
MG2 pfam01835
MG2 domain; This is the MG2 (macroglobulin) domain of alpha-2-macroglobulin in eukaryotes. ...
 122-173 6.32e-10

MG2 domain; This is the MG2 (macroglobulin) domain of alpha-2-macroglobulin in eukaryotes. Alpha-2-macroglobulins (A2Ms) are plasma proteins that trap and inhibit a broad range of proteases and are major components of the eukaryotic innate immune system. However, A2M-like proteins were identified in pathogenically invasive bacteria and species that colonize higher eukaryotes. This domain is found in eukaryotic and bacterial proteins. In human A2Ms, this domain is termed macroglobulin-like (MG) domain 2 and in Salmonella enterica ser A2Ms, this is domain 4.


Pssm-ID: 426464 [Multi-domain]  Cd Length: 95  Bit Score: 53.47  E-value: 6.32e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 333469289  122 SGLIQVDKPVFKPGDTVNFRVIVLDTELKPPARvKSVYVTIRDPQRNVIRKW 173
Cdd:pfam01835   1 RAFVYTDRGIYRPGETVHFKGLLRDQDLRPLAG-LPVTLTVTDPDGNEVRRL 51
YfaS COG2373
Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function ...
 128-172 2.15e-05

Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function prediction only];


Pssm-ID: 441940 [Multi-domain]  Cd Length: 1605  Bit Score: 43.92  E-value: 2.15e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 333469289  128 DKPVFKPGDTVNFRVIVLDTELKPPARVKsVYVTIRDPQRNVIRK 172
Cdd:COG2373   376 DRGIYRPGETVHLKALLRDADGKAPAGLP-LTLELTDPDGKEVRR 419
 
Name Accession Description Interval E-value
MG2 pfam01835
MG2 domain; This is the MG2 (macroglobulin) domain of alpha-2-macroglobulin in eukaryotes. ...
 122-173 6.32e-10

MG2 domain; This is the MG2 (macroglobulin) domain of alpha-2-macroglobulin in eukaryotes. Alpha-2-macroglobulins (A2Ms) are plasma proteins that trap and inhibit a broad range of proteases and are major components of the eukaryotic innate immune system. However, A2M-like proteins were identified in pathogenically invasive bacteria and species that colonize higher eukaryotes. This domain is found in eukaryotic and bacterial proteins. In human A2Ms, this domain is termed macroglobulin-like (MG) domain 2 and in Salmonella enterica ser A2Ms, this is domain 4.


Pssm-ID: 426464 [Multi-domain]  Cd Length: 95  Bit Score: 53.47  E-value: 6.32e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 333469289  122 SGLIQVDKPVFKPGDTVNFRVIVLDTELKPPARvKSVYVTIRDPQRNVIRKW 173
Cdd:pfam01835   1 RAFVYTDRGIYRPGETVHFKGLLRDQDLRPLAG-LPVTLTVTDPDGNEVRRL 51
YfaS COG2373
Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function ...
 128-172 2.15e-05

Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function prediction only];


Pssm-ID: 441940 [Multi-domain]  Cd Length: 1605  Bit Score: 43.92  E-value: 2.15e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 333469289  128 DKPVFKPGDTVNFRVIVLDTELKPPARVKsVYVTIRDPQRNVIRK 172
Cdd:COG2373   376 DRGIYRPGETVHLKALLRDADGKAPAGLP-LTLELTDPDGKEVRR 419
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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