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Conserved domains on  [gi|119568488|gb|EAW48103|]
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enoyl Coenzyme A hydratase domain containing 1, isoform CRA_c [Homo sapiens]

Protein Classification

enoyl-CoA hydratase/isomerase family protein( domain architecture ID 10787157)

enoyl-CoA hydratase/isomerase family protein similar to human ethylmalonyl-CoA decarboxylase that decarboxylates ethylmalonyl-CoA, a potentially toxic metabolite, to form butyryl-CoA

CATH:  3.90.226.10
Gene Ontology:  GO:0016829
PubMed:  12467702|22016388

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CaiD COG1024
Enoyl-CoA hydratase/carnithine racemase [Lipid transport and metabolism]; Enoyl-CoA hydratase ...
 19-149 5.79e-31

Enoyl-CoA hydratase/carnithine racemase [Lipid transport and metabolism]; Enoyl-CoA hydratase/carnithine racemase is part of the Pathway/BioSystem: Fatty acid biosynthesis


:

Pssm-ID: 440647 [Multi-domain]  Cd Length: 249  Bit Score: 111.41  E-value: 5.79e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119568488  19 GKILLGLSRLPLISVALVQGWALGGGAEFTTACDFRLMTPESKIRFVHKEMGIIPSWGGTTRLVEIIGSRQALKVLSGAL 98
Cdd:COG1024   82 QRLFRALRRLPKPVIAAVNGAALGGGLELALACDLRIAAEDARFGLPEVRLGLIPGGGGTQRLPRLVGLARAKELLLTGR 161

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 119568488  99 KLDSKNALNIGMVEEVLqSSDETksLEEAQEWLKQFIQGPPEVIRALKKSV 149
Cdd:COG1024  162 RIDAEEALELGLVNRVV-PDDEL--LAAALALAARLAAGPPLALAATKRAL 209
 
Name Accession Description Interval E-value
CaiD COG1024
Enoyl-CoA hydratase/carnithine racemase [Lipid transport and metabolism]; Enoyl-CoA hydratase ...
 19-149 5.79e-31

Enoyl-CoA hydratase/carnithine racemase [Lipid transport and metabolism]; Enoyl-CoA hydratase/carnithine racemase is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440647 [Multi-domain]  Cd Length: 249  Bit Score: 111.41  E-value: 5.79e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119568488  19 GKILLGLSRLPLISVALVQGWALGGGAEFTTACDFRLMTPESKIRFVHKEMGIIPSWGGTTRLVEIIGSRQALKVLSGAL 98
Cdd:COG1024   82 QRLFRALRRLPKPVIAAVNGAALGGGLELALACDLRIAAEDARFGLPEVRLGLIPGGGGTQRLPRLVGLARAKELLLTGR 161

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 119568488  99 KLDSKNALNIGMVEEVLqSSDETksLEEAQEWLKQFIQGPPEVIRALKKSV 149
Cdd:COG1024  162 RIDAEEALELGLVNRVV-PDDEL--LAAALALAARLAAGPPLALAATKRAL 209
crotonase-like cd06558
Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse ...
 20-133 6.48e-29

Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. Many of these play important roles in fatty acid metabolism. In addition to a conserved structural core and the formation of trimers (or dimers of trimers), a common feature in this superfamily is the stabilization of an enolate anion intermediate derived from an acyl-CoA substrate. This is accomplished by two conserved backbone NH groups in active sites that form an oxyanion hole.


Pssm-ID: 119339 [Multi-domain]  Cd Length: 195  Bit Score: 104.56  E-value: 6.48e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119568488  20 KILLGLSRLPLISVALVQGWALGGGAEFTTACDFRLMTPESKIRFVHKEMGIIPSWGGTTRLVEIIGSRQALKVLSGALK 99
Cdd:cd06558   84 ELLRALLRLPKPVIAAVNGAALGGGLELALACDIRIAAEDAKFGLPEVKLGLVPGGGGTQRLPRLVGPARARELLLTGRR 163

                         90       100       110
                 ....*....|....*....|....*....|....
gi 119568488 100 LDSKNALNIGMVEEVLqssDETKSLEEAQEWLKQ 133
Cdd:cd06558  164 ISAEEALELGLVDEVV---PDEELLAAALELARR 194
fadB PRK11730
fatty acid oxidation complex subunit alpha FadB;
20-148 1.06e-19

fatty acid oxidation complex subunit alpha FadB;


Pssm-ID: 183293 [Multi-domain]  Cd Length: 715  Bit Score: 84.14  E-value: 1.06e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119568488  20 KILLGLSRLPLISVALVQGWALGGGAEFTTACDFRLMTPESKIRFVHKEMGIIPSWGGTTRLVEIIGSRQALKVLSGALK 99
Cdd:PRK11730  93 SIFNRLEDLPVPTVAAINGYALGGGCECVLATDYRVASPDARIGLPETKLGIMPGFGGTVRLPRLIGADNALEWIAAGKD 172

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 119568488 100 LDSKNALNIGMVEEVLqSSDetKSLEEAQEWLKQFIQGPPE--VIRALKKS 148
Cdd:PRK11730 173 VRAEDALKVGAVDAVV-APE--KLQEAALALLKQAIAGKLDwkARRQPKLE 220
ECH_1 pfam00378
Enoyl-CoA hydratase/isomerase; This family contains a diverse set of enzymes including: ...
 20-149 1.19e-17

Enoyl-CoA hydratase/isomerase; This family contains a diverse set of enzymes including: enoyl-CoA hydratase, napthoate synthase, carnitate racemase, 3-hydroxybutyryl-CoA dehydratase and dodecanoyl-CoA delta-isomerase.


Pssm-ID: 395302 [Multi-domain]  Cd Length: 251  Bit Score: 76.63  E-value: 1.19e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119568488   20 KILLGLSRLPLISVALVQGWALGGGAEFTTACDFRLMTPESKIRFVHKEMGIIPSWGGTTRLVEIIGSRQALKVLSGALK 99
Cdd:pfam00378  79 DLWTLLYTCPKPVIAAVNGYAIGGGCELALACDIIIAADNASFGLNETKLGIIPGAGGTDRLPRIIGHSKAMEMLLLGRR 158

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 119568488  100 LDSKNALNIGMVEEVLQssdETKSLEEAQEWLKQFIQGPPEVIRALKKSV 149
Cdd:pfam00378 159 ISAQEALKWGLVDKVVP---EDQLLDEARELAEKLAEKSPAALAQLKKAL 205
menB TIGR01929
naphthoate synthase (dihydroxynaphthoic acid synthetase); This model represents an enzyme, ...
 7-148 1.37e-09

naphthoate synthase (dihydroxynaphthoic acid synthetase); This model represents an enzyme, naphthoate synthase (dihydroxynaphthoic acid synthetase), which is involved in the fifth step of the menaquinone biosynthesis pathway. Together with o-succinylbenzoate-CoA ligase (menE: TIGR01923), this enzyme takes 2-succinylbenzoate and converts it into 1,4-di-hydroxy-2-naphthoate. Included above the trusted cutoff are two enzymes from Arabadopsis thaliana and one from Staphylococcus aureus which are identified as putative enoyl-CoA hydratase/isomerases. These enzymes group with the naphthoate synthases when building a tree and when doing BLAST searches. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 200143 [Multi-domain]  Cd Length: 259  Bit Score: 54.47  E-value: 1.37e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119568488    7 HLNkIYEVKKQrgkillgLSRLPLISVALVQGWALGGGAEFTTACDFRLMTPESKIRFVHKEMGIIPSWGGTTRLVEIIG 86
Cdd:TIGR01929  83 RLN-VLDVQRQ-------IRTCPKPVIAMVNGYAIGGGHVLHMMCDLTIAAENARFGQTGPKVGSFDGGYGSSYMARIVG 154

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 119568488   87 SRQALKVLSGALKLDSKNALNIGMVEEVLQSSDetksLE-EAQEWLKQFIQGPPEVIRALKKS 148
Cdd:TIGR01929 155 QKKAREIWFLCRQYDAKQALDMGLVNTVVPLAD----LEkETVRWCREILQKSPMAIRMLKAA 213
 
Name Accession Description Interval E-value
CaiD COG1024
Enoyl-CoA hydratase/carnithine racemase [Lipid transport and metabolism]; Enoyl-CoA hydratase ...
 19-149 5.79e-31

Enoyl-CoA hydratase/carnithine racemase [Lipid transport and metabolism]; Enoyl-CoA hydratase/carnithine racemase is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440647 [Multi-domain]  Cd Length: 249  Bit Score: 111.41  E-value: 5.79e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119568488  19 GKILLGLSRLPLISVALVQGWALGGGAEFTTACDFRLMTPESKIRFVHKEMGIIPSWGGTTRLVEIIGSRQALKVLSGAL 98
Cdd:COG1024   82 QRLFRALRRLPKPVIAAVNGAALGGGLELALACDLRIAAEDARFGLPEVRLGLIPGGGGTQRLPRLVGLARAKELLLTGR 161

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 119568488  99 KLDSKNALNIGMVEEVLqSSDETksLEEAQEWLKQFIQGPPEVIRALKKSV 149
Cdd:COG1024  162 RIDAEEALELGLVNRVV-PDDEL--LAAALALAARLAAGPPLALAATKRAL 209
crotonase-like cd06558
Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse ...
 20-133 6.48e-29

Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. Many of these play important roles in fatty acid metabolism. In addition to a conserved structural core and the formation of trimers (or dimers of trimers), a common feature in this superfamily is the stabilization of an enolate anion intermediate derived from an acyl-CoA substrate. This is accomplished by two conserved backbone NH groups in active sites that form an oxyanion hole.


Pssm-ID: 119339 [Multi-domain]  Cd Length: 195  Bit Score: 104.56  E-value: 6.48e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119568488  20 KILLGLSRLPLISVALVQGWALGGGAEFTTACDFRLMTPESKIRFVHKEMGIIPSWGGTTRLVEIIGSRQALKVLSGALK 99
Cdd:cd06558   84 ELLRALLRLPKPVIAAVNGAALGGGLELALACDIRIAAEDAKFGLPEVKLGLVPGGGGTQRLPRLVGPARARELLLTGRR 163

                         90       100       110
                 ....*....|....*....|....*....|....
gi 119568488 100 LDSKNALNIGMVEEVLqssDETKSLEEAQEWLKQ 133
Cdd:cd06558  164 ISAEEALELGLVDEVV---PDEELLAAALELARR 194
fadB PRK11730
fatty acid oxidation complex subunit alpha FadB;
20-148 1.06e-19

fatty acid oxidation complex subunit alpha FadB;


Pssm-ID: 183293 [Multi-domain]  Cd Length: 715  Bit Score: 84.14  E-value: 1.06e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119568488  20 KILLGLSRLPLISVALVQGWALGGGAEFTTACDFRLMTPESKIRFVHKEMGIIPSWGGTTRLVEIIGSRQALKVLSGALK 99
Cdd:PRK11730  93 SIFNRLEDLPVPTVAAINGYALGGGCECVLATDYRVASPDARIGLPETKLGIMPGFGGTVRLPRLIGADNALEWIAAGKD 172

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 119568488 100 LDSKNALNIGMVEEVLqSSDetKSLEEAQEWLKQFIQGPPE--VIRALKKS 148
Cdd:PRK11730 173 VRAEDALKVGAVDAVV-APE--KLQEAALALLKQAIAGKLDwkARRQPKLE 220
ECH_1 pfam00378
Enoyl-CoA hydratase/isomerase; This family contains a diverse set of enzymes including: ...
 20-149 1.19e-17

Enoyl-CoA hydratase/isomerase; This family contains a diverse set of enzymes including: enoyl-CoA hydratase, napthoate synthase, carnitate racemase, 3-hydroxybutyryl-CoA dehydratase and dodecanoyl-CoA delta-isomerase.


Pssm-ID: 395302 [Multi-domain]  Cd Length: 251  Bit Score: 76.63  E-value: 1.19e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119568488   20 KILLGLSRLPLISVALVQGWALGGGAEFTTACDFRLMTPESKIRFVHKEMGIIPSWGGTTRLVEIIGSRQALKVLSGALK 99
Cdd:pfam00378  79 DLWTLLYTCPKPVIAAVNGYAIGGGCELALACDIIIAADNASFGLNETKLGIIPGAGGTDRLPRIIGHSKAMEMLLLGRR 158

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 119568488  100 LDSKNALNIGMVEEVLQssdETKSLEEAQEWLKQFIQGPPEVIRALKKSV 149
Cdd:pfam00378 159 ISAQEALKWGLVDKVVP---EDQLLDEARELAEKLAEKSPAALAQLKKAL 205
PRK07658 PRK07658
enoyl-CoA hydratase; Provisional
 29-145 1.93e-15

enoyl-CoA hydratase; Provisional


Pssm-ID: 181070 [Multi-domain]  Cd Length: 257  Bit Score: 70.82  E-value: 1.93e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119568488  29 PLIsvALVQGWALGGGAEFTTACDFRLMTPESKIRFVHKEMGIIPSWGGTTRLVEIIGSRQALKVLSGALKLDSKNALNI 108
Cdd:PRK07658  96 PVI--AAIHGAALGGGLELAMSCHIRFATESAKLGLPELNLGLIPGFAGTQRLPRYVGKAKALEMMLTSEPITGAEALKW 173

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 119568488 109 GMVEEVLqssDETKSLEEAQEWLKQFIQGPPEVIRAL 145
Cdd:PRK07658 174 GLVNGVF---PEETLLDDAKKLAKKIAGKSPATTRAV 207
PRK05809 PRK05809
short-chain-enoyl-CoA hydratase;
20-149 2.74e-15

short-chain-enoyl-CoA hydratase;


Pssm-ID: 180270 [Multi-domain]  Cd Length: 260  Bit Score: 70.16  E-value: 2.74e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119568488  20 KILLGLSRLPLISVALVQGWALGGGAEFTTACDFRLMTpeSKIRFVHKE--MGIIPSWGGTTRLVEIIGSRQALKVLSGA 97
Cdd:PRK05809  88 KVFRKLENLDKPVIAAINGFALGGGCELSMACDIRIAS--EKAKFGQPEvgLGITPGFGGTQRLARIVGPGKAKELIYTG 165

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 119568488  98 LKLDSKNALNIGMVEEVLQSSdetKSLEEAQEWLKQFIQGPPEVIRALKKSV 149
Cdd:PRK05809 166 DMINAEEALRIGLVNKVVEPE---KLMEEAKALANKIAANAPIAVKLCKDAI 214
PRK06144 PRK06144
enoyl-CoA hydratase; Provisional
 12-149 9.22e-15

enoyl-CoA hydratase; Provisional


Pssm-ID: 180424 [Multi-domain]  Cd Length: 262  Bit Score: 68.87  E-value: 9.22e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119568488  12 YEVKKQRgkILLGLSRLPLISVALVQGWALGGGAEFTTACDFRLMTPESKIRF-VHKEMGIIPSWGGTTRLVEIIGSRQA 90
Cdd:PRK06144  87 YERRIDR--VLGALEQLRVPTIAAIAGACVGGGAAIAAACDLRIATPSARFGFpIARTLGNCLSMSNLARLVALLGAARV 164

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 119568488  91 LKVLSGALKLDSKNALNIGMVEEVLQssDETKSlEEAQEWLKQFIQGPPEVIRALKKSV 149
Cdd:PRK06144 165 KDMLFTARLLEAEEALAAGLVNEVVE--DAALD-ARADALAELLAAHAPLTLRATKEAL 220
PLN02600 PLN02600
enoyl-CoA hydratase
 28-149 5.29e-14

enoyl-CoA hydratase


Pssm-ID: 178210 [Multi-domain]  Cd Length: 251  Bit Score: 66.75  E-value: 5.29e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119568488  28 LPLISVALVQGWALGGGAEFTTACDFRLMTPESKIRFVHKEMGIIPSWGGTTRLVEIIGSRQALKVLSGALKLDSKNALN 107
Cdd:PLN02600  87 LSIPTIAVVEGAALGGGLELALSCDLRICGEEAVFGLPETGLAIIPGAGGTQRLPRLVGRSRAKELIFTGRRIGAREAAS 166

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 119568488 108 IGMVEEVLQSSDE-TKSLEEAQEwlkqFIQGPPEVIRALKKSV 149
Cdd:PLN02600 167 MGLVNYCVPAGEAyEKALELAQE----INQKGPLAIKMAKKAI 205
PRK05869 PRK05869
enoyl-CoA hydratase; Validated
 25-149 5.79e-14

enoyl-CoA hydratase; Validated


Pssm-ID: 235632 [Multi-domain]  Cd Length: 222  Bit Score: 66.02  E-value: 5.79e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119568488  25 LSRLPLISVALVQGWALGGGAEFTTACDFRLMTPESKIRFVHKEMGIIPSWGGTTRLVEIIGSRQALK-VLSGALkLDSK 103
Cdd:PRK05869  95 VAAIPKPTVAAITGYALGAGLTLALAADWRVSGDNVKFGATEILAGLAPSGDGMARLTRAAGPSRAKElVFSGRF-FDAE 173

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 119568488 104 NALNIGMVEEVLQSSDetkSLEEAQEWLKQFIQGPPEVIRALKKSV 149
Cdd:PRK05869 174 EALALGLIDEMVAPDD---VYDAAAAWARRFLDGPPHALAAAKAGI 216
PRK05870 PRK05870
enoyl-CoA hydratase; Provisional
 8-149 1.81e-13

enoyl-CoA hydratase; Provisional


Pssm-ID: 180298  Cd Length: 249  Bit Score: 65.13  E-value: 1.81e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119568488   8 LNKIYEVkkqrgkiLLGLSRLPLISVALVQGWALGGGAEFTTACDFRLMTPESK--IRFVhkEMGIIPSWGGTTRLVEII 85
Cdd:PRK05870  81 LRRIYDG-------FLAVASCPLPTIAAVNGAAVGAGLNLALAADVRIAGPKALfdARFQ--KLGLHPGGGATWMLQRAV 151

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 119568488  86 GSRQALKVLSGALKLDSKNALNIGMVEEVlqsSDETksLEEAQEWLKQFIQGPPEVIRALKKSV 149
Cdd:PRK05870 152 GPQVARAALLFGMRFDAEAAVRHGLALMV---ADDP--VAAALELAAGPAAAPRELVLATKASM 210
PRK07657 PRK07657
enoyl-CoA hydratase; Provisional
 19-128 5.76e-13

enoyl-CoA hydratase; Provisional


Pssm-ID: 181069 [Multi-domain]  Cd Length: 260  Bit Score: 63.99  E-value: 5.76e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119568488  19 GKILLGLSRLPLISVALVQGWALGGGAEFTTACDFRLMTPESKIRFVHKEMGIIPSWGGTTRLVEIIGSRQALKVLSGAL 98
Cdd:PRK07657  87 RTTMEMVEQLPQPVIAAINGIALGGGLELALACDFRIAAESASLGLTETTLAIIPGAGGTQRLPRLIGVGRAKELIYTGR 166

                         90       100       110
                 ....*....|....*....|....*....|.
gi 119568488  99 KLDSKNALNIGMVEEVLQSSD-ETKSLEEAQ 128
Cdd:PRK07657 167 RISAQEAKEIGLVEFVVPAHLlEEKAIEIAE 197
PRK08138 PRK08138
enoyl-CoA hydratase; Provisional
 29-149 2.89e-12

enoyl-CoA hydratase; Provisional


Pssm-ID: 236162 [Multi-domain]  Cd Length: 261  Bit Score: 61.99  E-value: 2.89e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119568488  29 PLIsvALVQGWALGGGAEFTTACDF-------RLMTPESKIrfvhkemGIIPSWGGTTRLVEIIGSRQALK-VLSGALkL 100
Cdd:PRK08138 100 PVI--AAVNGYALGGGCELAMHADIivagesaSFGQPEIKV-------GLMPGAGGTQRLVRAVGKFKAMRmALTGCM-V 169

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 119568488 101 DSKNALNIGMVEEVlqsSDETKSLEEAQEWLKQFIQGPPEVIRALKKSV 149
Cdd:PRK08138 170 PAPEALAIGLVSEV---VEDEQTLPRALELAREIARMPPLALAQIKEVV 215
PRK07509 PRK07509
crotonase/enoyl-CoA hydratase family protein;
23-149 5.06e-12

crotonase/enoyl-CoA hydratase family protein;


Pssm-ID: 181008 [Multi-domain]  Cd Length: 262  Bit Score: 61.43  E-value: 5.06e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119568488  23 LGLSRLPLISVALVQGWALGGGAEFTTACDFRLMTPESKIRFVHKEMGIIPSWGGTTRLVEIIGSRQALKVLSGALKLDS 102
Cdd:PRK07509  96 LGWRRLPVPVIAALEGVCFGGGLQIALGADIRIAAPDTKLSIMEAKWGLVPDMAGTVSLRGLVRKDVARELTYTARVFSA 175

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 119568488 103 KNALNIGMVEEVlqsSDETksLEEAQEWLKQFIQGPPEVIRALKKSV 149
Cdd:PRK07509 176 EEALELGLVTHV---SDDP--LAAALALAREIAQRSPDAIAAAKRLI 217
fadJ PRK11154
fatty acid oxidation complex subunit alpha FadJ;
25-118 6.60e-12

fatty acid oxidation complex subunit alpha FadJ;


Pssm-ID: 236864 [Multi-domain]  Cd Length: 708  Bit Score: 61.84  E-value: 6.60e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119568488  25 LSRLPLISVALVQGWALGGGAEFTTACDFRLMTPESKIRFVHKE--MGIIPSWGGTTRLVEIIGSRQALK-VLSGAlKLD 101
Cdd:PRK11154  97 IEALPIPVVAAIHGACLGGGLELALACHYRVCTDDPKTVLGLPEvqLGLLPGSGGTQRLPRLIGVSTALDmILTGK-QLR 175

                         90
                 ....*....|....*..
gi 119568488 102 SKNALNIGMVEEVLQSS 118
Cdd:PRK11154 176 AKQALKLGLVDDVVPHS 192
PRK06494 PRK06494
enoyl-CoA hydratase; Provisional
 29-149 8.84e-12

enoyl-CoA hydratase; Provisional


Pssm-ID: 180591 [Multi-domain]  Cd Length: 259  Bit Score: 60.83  E-value: 8.84e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119568488  29 PLIsvALVQGWALGGGAEFTTACD---------FRLmtPESKIrfvhkemGIIPSWGGTTRLVEIIGSRQALKVLSGALK 99
Cdd:PRK06494  96 PII--AAVNGVAMGGGFELALACDlivaaenatFAL--PEPRV-------GLAALAGGLHRLPRQIGLKRAMGMILTGRR 164

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 119568488 100 LDSKNALNIGMVEEVLQSSDetkSLEEAQEWLKQFIQGPPEVIRALKKSV 149
Cdd:PRK06494 165 VTAREGLELGFVNEVVPAGE---LLAAAERWADDILACSPLSIRASKQAV 211
PRK06127 PRK06127
enoyl-CoA hydratase; Provisional
 32-149 2.31e-11

enoyl-CoA hydratase; Provisional


Pssm-ID: 235705  Cd Length: 269  Bit Score: 59.72  E-value: 2.31e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119568488  32 SVALVQGWALGGGAEFTTACDFRLMTPESKIRFVHKEMGIIPSWGGTTRLVEIIGSRQALKVLSGALKLDSKNALNIGMV 111
Cdd:PRK06127 109 TIACIRGYCIGGGMGIALACDIRIAAEDSRFGIPAARLGLGYGYDGVKNLVDLVGPSAAKDLFYTARRFDAAEALRIGLV 188

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 119568488 112 EEVLQSSDetksLE-EAQEWLKQFIQGPPEVIRALKKSV 149
Cdd:PRK06127 189 HRVTAADD----LEtALADYAATIAGNAPLTLRAAKRAI 223
PRK09674 PRK09674
enoyl-CoA hydratase-isomerase; Provisional
 29-149 3.02e-11

enoyl-CoA hydratase-isomerase; Provisional


Pssm-ID: 182026 [Multi-domain]  Cd Length: 255  Bit Score: 59.39  E-value: 3.02e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119568488  29 PLIsvALVQGWALGGGAEFTTACDfrLMTPESKIRFVHKE--MGIIPSWGGTTRLVEIIGSRQALK-VLSGAlKLDSKNA 105
Cdd:PRK09674  94 PLI--AAVNGYALGAGCELALLCD--IVIAGENARFGLPEitLGIMPGAGGTQRLIRSVGKSLASQmVLTGE-SITAQQA 168

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 119568488 106 LNIGMVEEVLQSSdetKSLEEAQEWLKQFIQGPPEVIRALKKSV 149
Cdd:PRK09674 169 QQAGLVSEVFPPE---LTLERALQLASKIARHSPLALRAAKQAL 209
PRK06688 PRK06688
enoyl-CoA hydratase; Provisional
 21-146 3.46e-11

enoyl-CoA hydratase; Provisional


Pssm-ID: 235852 [Multi-domain]  Cd Length: 259  Bit Score: 59.11  E-value: 3.46e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119568488  21 ILLGLSRLPLISVALVQGWALGGGAEFTTACDFR-------LMTPESKIrfvhkemGIIPSWGGTTRLVEIIGS-RQALK 92
Cdd:PRK06688  88 FLRAIAALPKPVVAAVNGPAVGVGVSLALACDLVyasesakFSLPFAKL-------GLCPDAGGSALLPRLIGRaRAAEM 160

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 119568488  93 VLSGAlKLDSKNALNIGMVEEVLQSSDetkSLEEAQEWLKQFIQGPPEVIRALK 146
Cdd:PRK06688 161 LLLGE-PLSAEEALRIGLVNRVVPAAE---LDAEADAQAAKLAAGPASALRYTK 210
PRK03580 PRK03580
crotonobetainyl-CoA hydratase;
29-149 6.11e-11

crotonobetainyl-CoA hydratase;


Pssm-ID: 179599 [Multi-domain]  Cd Length: 261  Bit Score: 58.55  E-value: 6.11e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119568488  29 PLIsvALVQGWALGGGAEFTTACDFRLMTPESKIRFVHKEMGIIPSWGGTTRLVEIIGSRQALKVLSGALKLDSKNALNI 108
Cdd:PRK03580  96 PVI--AAVNGYAFGGGFELALAADFIVCADNASFALPEAKLGIVPDSGGVLRLPKRLPPAIANEMVMTGRRMDAEEALRW 173

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 119568488 109 GMVEEVLQSsdeTKSLEEAQEWLKQFIQGPPEVIRALKKSV 149
Cdd:PRK03580 174 GIVNRVVPQ---AELMDRARELAQQLVNSAPLAIAALKEIY 211
PRK06190 PRK06190
enoyl-CoA hydratase; Provisional
 27-148 1.48e-10

enoyl-CoA hydratase; Provisional


Pssm-ID: 235733  Cd Length: 258  Bit Score: 57.29  E-value: 1.48e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119568488  27 RLPLISValVQGWALGGGAEFTTACDFrLMTPEsKIRF--VHKEMGIIPSWGGTTRLVEIIGSRQALKV-LSGALkLDSK 103
Cdd:PRK06190  94 RKPVIGA--INGAAVTGGLELALACDI-LIASE-RARFadTHARVGILPGWGLSVRLPQKVGIGRARRMsLTGDF-LDAA 168

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 119568488 104 NALNIGMVEEVLQSSDetkSLEEAQEWLKQFIQGPPEVIRALKKS 148
Cdd:PRK06190 169 DALRAGLVTEVVPHDE---LLPRARRLAASIAGNNPAAVRALKAS 210
PLN02888 PLN02888
enoyl-CoA hydratase
 27-129 2.56e-10

enoyl-CoA hydratase


Pssm-ID: 215480  Cd Length: 265  Bit Score: 56.68  E-value: 2.56e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119568488  27 RLPLISValVQGWALGGGAEFTTACDFRLMTPESKIRFVHKEMGIIPSWGGTTRLVEIIGSRQALKVLSGALKLDSKNAL 106
Cdd:PLN02888  99 RKPIIGA--INGFAITAGFEIALACDILVASRGAKFIDTHAKFGIFPSWGLSQKLSRIIGANRAREVSLTAMPLTAETAE 176

                         90       100
                 ....*....|....*....|...
gi 119568488 107 NIGMVEEVLqssDETKSLEEAQE 129
Cdd:PLN02888 177 RWGLVNHVV---EESELLKKARE 196
PRK09076 PRK09076
enoyl-CoA hydratase; Provisional
 31-147 4.07e-10

enoyl-CoA hydratase; Provisional


Pssm-ID: 236373 [Multi-domain]  Cd Length: 258  Bit Score: 56.08  E-value: 4.07e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119568488  31 ISVALVQGWALGGGAEFTTACDFR-------LMTPESKIrfvhkemGIIPSWGGTTRLVEIIGSRQALKVLSGALKLDSK 103
Cdd:PRK09076  97 VSIAAINGYAMGGGLECALACDIRiaeeqaqMALPEASV-------GLLPCAGGTQNLPWLVGEGWAKRMILCGERVDAA 169

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 119568488 104 NALNIGMVEEVLqssDETKSLEEAQEWLKQFIQGPPEVIRALKK 147
Cdd:PRK09076 170 TALRIGLVEEVV---EKGEAREAALALAQKVANQSPSAVAACKT 210
menB TIGR01929
naphthoate synthase (dihydroxynaphthoic acid synthetase); This model represents an enzyme, ...
 7-148 1.37e-09

naphthoate synthase (dihydroxynaphthoic acid synthetase); This model represents an enzyme, naphthoate synthase (dihydroxynaphthoic acid synthetase), which is involved in the fifth step of the menaquinone biosynthesis pathway. Together with o-succinylbenzoate-CoA ligase (menE: TIGR01923), this enzyme takes 2-succinylbenzoate and converts it into 1,4-di-hydroxy-2-naphthoate. Included above the trusted cutoff are two enzymes from Arabadopsis thaliana and one from Staphylococcus aureus which are identified as putative enoyl-CoA hydratase/isomerases. These enzymes group with the naphthoate synthases when building a tree and when doing BLAST searches. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 200143 [Multi-domain]  Cd Length: 259  Bit Score: 54.47  E-value: 1.37e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119568488    7 HLNkIYEVKKQrgkillgLSRLPLISVALVQGWALGGGAEFTTACDFRLMTPESKIRFVHKEMGIIPSWGGTTRLVEIIG 86
Cdd:TIGR01929  83 RLN-VLDVQRQ-------IRTCPKPVIAMVNGYAIGGGHVLHMMCDLTIAAENARFGQTGPKVGSFDGGYGSSYMARIVG 154

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 119568488   87 SRQALKVLSGALKLDSKNALNIGMVEEVLQSSDetksLE-EAQEWLKQFIQGPPEVIRALKKS 148
Cdd:TIGR01929 155 QKKAREIWFLCRQYDAKQALDMGLVNTVVPLAD----LEkETVRWCREILQKSPMAIRMLKAA 213
PRK06142 PRK06142
crotonase/enoyl-CoA hydratase family protein;
27-146 1.78e-09

crotonase/enoyl-CoA hydratase family protein;


Pssm-ID: 235714  Cd Length: 272  Bit Score: 54.21  E-value: 1.78e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119568488  27 RLPLIsvALVQGWALGGGAEFTTACDFRLMTPESKirFVHKE--MGIIPSWGGTTRLVEIIGSRQALKVLSGALKLDSKN 104
Cdd:PRK06142 109 RKPVI--AAVQGWCIGGGVDLISACDMRYASADAK--FSVREvdLGMVADVGSLQRLPRIIGDGHLRELALTGRDIDAAE 184

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 119568488 105 ALNIGMVEEVLqsSDETKSLEEAQEWLKQFIQGPPEVIRALK 146
Cdd:PRK06142 185 AEKIGLVNRVY--DDADALLAAAHATAREIAAKSPLAVRGTK 224
PRK08260 PRK08260
enoyl-CoA hydratase; Provisional
 26-114 1.90e-09

enoyl-CoA hydratase; Provisional


Pssm-ID: 236206 [Multi-domain]  Cd Length: 296  Bit Score: 54.24  E-value: 1.90e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119568488  26 SRLPLIsvALVQGWALGGGAEFTTACDFRLMTPESKIRFVHKEMGIIPSWGGTTRLVEIIGSRQALK-VLSGALkLDSKN 104
Cdd:PRK08260 112 SLKPVI--AAVNGPAVGVGATMTLAMDIRLASTAARFGFVFGRRGIVPEAASSWFLPRLVGLQTALEwVYSGRV-FDAQE 188

                         90
                 ....*....|
gi 119568488 105 ALNIGMVEEV 114
Cdd:PRK08260 189 ALDGGLVRSV 198
PRK05674 PRK05674
gamma-carboxygeranoyl-CoA hydratase; Validated
 19-146 2.46e-08

gamma-carboxygeranoyl-CoA hydratase; Validated


Pssm-ID: 168168  Cd Length: 265  Bit Score: 50.96  E-value: 2.46e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119568488  19 GKILLGLSRLPLISVALVQGWALGGGAEFTTACDFRLMTPESKIRFVHKEMGIIPSWGGTTrLVEIIGSRQALKVLSGAL 98
Cdd:PRK05674  91 AELMYNLYRLKIPTLAVVQGAAFGGALGLISCCDMAIGADDAQFCLSEVRIGLAPAVISPF-VVKAIGERAARRYALTAE 169

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 119568488  99 KLDSKNALNIGMVEEVLQSSDetksLE-EAQEWLKQFIQGPPEVIRALK 146
Cdd:PRK05674 170 RFDGRRARELGLLAESYPAAE----LEaQVEAWIANLLLNSPQALRASK 214
fa_ox_alpha_mit TIGR02441
fatty acid oxidation complex, alpha subunit, mitochondrial; Members represent alpha subunit of ...
 33-116 4.90e-08

fatty acid oxidation complex, alpha subunit, mitochondrial; Members represent alpha subunit of mitochondrial multifunctional fatty acid degradation enzyme complex. Subunit activities include: enoyl-CoA hydratase (EC 4.2.1.17) _ 3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.35). Some characterization in human (SP:P40939), pig (SP:Q29554), and rat (SP:Q64428). The beta subunit has activity: acetyl-CoA C-acyltransferase (EC 2.3.1.16).


Pssm-ID: 131494 [Multi-domain]  Cd Length: 737  Bit Score: 50.61  E-value: 4.90e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119568488   33 VALVQGWALGGGAEFTTACDFRLMTPESKIRFVHKE--MGIIPSWGGTTRLVEIIGSRQALKVLSGALKLDSKNALNIGM 110
Cdd:TIGR02441 112 VAAISGSCLGGGLELALACHYRIATKDRKTLLGLPEvmLGLLPGAGGTQRLPKLTGVPAALDMMLTGKKIRADRAKKMGI 191


                  ....*.
gi 119568488  111 VEEVLQ 116
Cdd:TIGR02441 192 VDQLVD 197
PRK05862 PRK05862
enoyl-CoA hydratase; Provisional
 27-129 4.99e-08

enoyl-CoA hydratase; Provisional


Pssm-ID: 180295 [Multi-domain]  Cd Length: 257  Bit Score: 50.04  E-value: 4.99e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119568488  27 RLPLIsvALVQGWALGGGAEFTTACDF-------RLMTPESKirfvhkeMGIIPSWGGTTRLVEIIGSRQALKVLSGALK 99
Cdd:PRK05862  94 RKPVI--AAVAGYALGGGCELAMMCDIiiaadtaKFGQPEIK-------LGVLPGMGGSQRLTRAVGKAKAMDLCLTGRM 164

                         90       100       110
                 ....*....|....*....|....*....|
gi 119568488 100 LDSKNALNIGMVEEVLQSSdetKSLEEAQE 129
Cdd:PRK05862 165 MDAAEAERAGLVSRVVPAD---KLLDEALA 191
PRK06563 PRK06563
crotonase/enoyl-CoA hydratase family protein;
29-148 1.08e-07

crotonase/enoyl-CoA hydratase family protein;


Pssm-ID: 180625 [Multi-domain]  Cd Length: 255  Bit Score: 49.19  E-value: 1.08e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119568488  29 PLISValVQGWALGGGAEFTTACDFRLMTpeSKIRFVHKEM--GIIPSWGGTTRLVEIIGSRQALKVLSGALKLDSKNAL 106
Cdd:PRK06563  94 PLVVA--VQGYCLTLGIELMLAADIVVAA--DNTRFAQLEVqrGILPFGGATLRFPQAAGWGNAMRYLLTGDEFDAQEAL 169

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 119568488 107 NIGMVEEVLQSSDE-TKSLEEAQEWLKQfiqgPPEVIRALKKS 148
Cdd:PRK06563 170 RLGLVQEVVPPGEQlERAIELAERIARA----APLGVQATLAS 208
PRK06143 PRK06143
enoyl-CoA hydratase; Provisional
 28-146 2.79e-07

enoyl-CoA hydratase; Provisional


Pssm-ID: 180423  Cd Length: 256  Bit Score: 48.11  E-value: 2.79e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119568488  28 LPLISVALVQGWALGGGAEFTTACDFRLMT-------PESKIRfvhkemgiIPSWGGTTRLVEIIG-SRQALKVLSGALk 99
Cdd:PRK06143  99 FPVPVIARIPGWCLGGGLELAAACDLRIAAhdaqfgmPEVRVG--------IPSVIHAALLPRLIGwARTRWLLLTGET- 169

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 119568488 100 LDSKNALNIGMVEEVLQSSDETKSLEEAQEWLKQFiqgPPEVIRALK 146
Cdd:PRK06143 170 IDAAQALAWGLVDRVVPLAELDAAVERLAASLAGC---GPQALRQQK 213
PRK07854 PRK07854
enoyl-CoA hydratase; Provisional
 22-130 5.49e-07

enoyl-CoA hydratase; Provisional


Pssm-ID: 236115 [Multi-domain]  Cd Length: 243  Bit Score: 47.33  E-value: 5.49e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119568488  22 LLGLSRLPLISVALVQGWALGGGAEFTTACDFRLMTPESKIRFVHKEMGI-IPSWgGTTRLVEIIGSRQALKVLSGALKL 100
Cdd:PRK07854  79 LHAIDAAPVPVIAAINGPAIGAGLQLAMACDLRVVAPEAYFQFPVAKYGIaLDNW-TIRRLSSLVGGGRARAMLLGAEKL 157

                         90       100       110
                 ....*....|....*....|....*....|
gi 119568488 101 DSKNALNIGMVEEVlqssdetKSLEEAQEW 130
Cdd:PRK07854 158 TAEQALATGMANRI-------GTLADAQAW 180
PRK09245 PRK09245
crotonase/enoyl-CoA hydratase family protein;
24-147 5.91e-07

crotonase/enoyl-CoA hydratase family protein;


Pssm-ID: 181723  Cd Length: 266  Bit Score: 47.27  E-value: 5.91e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119568488  24 GLSRLPLI-------SVALVQGWALGGGAEFTTACDFRLMTPESKI--RFVhkEMGIIPSWGGTTRLVEIIG-SRQALKV 93
Cdd:PRK09245  91 GIQRIPLAlynlevpVIAAVNGPAIGAGCDLACMCDIRIASETARFaeSFV--KLGLIPGDGGAWLLPRIIGmARAAEMA 168

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 119568488  94 LSGAlKLDSKNALNIGMVEEVLQSSDetkSLEEAQEWLKQFIQGPPEVIRALKK 147
Cdd:PRK09245 169 FTGD-AIDAATALEWGLVSRVVPADQ---LLPAARALAERIAANPPHALRLTKR 218
PLN02664 PLN02664
enoyl-CoA hydratase/delta3,5-delta2,4-dienoyl-CoA isomerase
 27-120 8.54e-07

enoyl-CoA hydratase/delta3,5-delta2,4-dienoyl-CoA isomerase


Pssm-ID: 178269 [Multi-domain]  Cd Length: 275  Bit Score: 46.82  E-value: 8.54e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119568488  27 RLPLIsvALVQGWALGGGAEFTTACDFRLMTPESKIRFVHKEMGIIPSWGGTTRLVEIIGSRQALKVLSGALKLDSKNAL 106
Cdd:PLN02664 111 RKPVI--AAIHGACIGGGVDIVTACDIRYCSEDAFFSVKEVDLAITADLGTLQRLPSIVGYGNAMELALTGRRFSGSEAK 188

                         90
                 ....*....|....
gi 119568488 107 NIGMVEEVLQSSDE 120
Cdd:PLN02664 189 ELGLVSRVFGSKED 202
PRK08321 PRK08321
1,4-dihydroxy-2-naphthoyl-CoA synthase;
11-146 1.06e-06

1,4-dihydroxy-2-naphthoyl-CoA synthase;


Pssm-ID: 181386  Cd Length: 302  Bit Score: 46.56  E-value: 1.06e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119568488  11 IYEVkkQRgkillgLSR-LPLISVALVQGWALGGGAEFTTACDFRLMTPE-SKIRFVHKEMGIIPSWGGTTRLVEIIGSR 88
Cdd:PRK08321 124 ILEV--QR------LIRfMPKVVIAVVPGWAAGGGHSLHVVCDLTLASREhARFKQTDADVGSFDGGYGSAYLARQVGQK 195

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 119568488  89 QALKVLSGALKLDSKNALNIGMVEEVLQSSDetksLE-EAQEWLKQFIQGPPEVIRALK 146
Cdd:PRK08321 196 FAREIFFLGRTYSAEEAHDMGAVNAVVPHAE----LEtEALEWAREINGKSPTAMRMLK 250
PLN03214 PLN03214
probable enoyl-CoA hydratase/isomerase; Provisional
 22-149 1.35e-06

probable enoyl-CoA hydratase/isomerase; Provisional


Pssm-ID: 215635  Cd Length: 278  Bit Score: 46.41  E-value: 1.35e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119568488  22 LLGLSRLPLISVALVQGWALGGGAEFTTACDFRLMTPESKIRFVHKEMGI-IPSWGGTTRLVEIIGSRQA-LKVLSGALk 99
Cdd:PLN03214 100 LVRLLRSRLATVCAIRGACPAGGCAVSLCCDYRLQTTEGTMGLNEVALGIpVPKFWARLFMGRVIDRKVAeSLLLRGRL- 178

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 119568488 100 LDSKNALNIGMVEEVLQSSdetKSLEEAQEWLKQFIQGPPEVIRALKKSV 149
Cdd:PLN03214 179 VRPAEAKQLGLIDEVVPAA---ALMEAAASAMERALKLPSAARAATKALL 225
PRK09120 PRK09120
p-hydroxycinnamoyl CoA hydratase/lyase; Validated
 32-146 3.88e-06

p-hydroxycinnamoyl CoA hydratase/lyase; Validated


Pssm-ID: 236383  Cd Length: 275  Bit Score: 45.00  E-value: 3.88e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119568488  32 SVALVQGWALGGGAEFTTACDFRLMTPESKIRFVHKEMGIIPSWGGTTRLVEIIGSRQAL-KVLSGALkLDSKNALNIGM 110
Cdd:PRK09120 107 TIAMVNGWCFGGGFSPLVACDLAIAADEAQFGLSEINWGIPPGGGVSKAMADTVGHRDALyYIMTGET-FTGRKAAEMGL 185

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 119568488 111 VEEVLQSSD-ETKSLEEAQEWLKQfiqgPPEVIRALK 146
Cdd:PRK09120 186 VNESVPLAQlRARTRELAAKLLEK----NPVVLRAAK 218
PRK08258 PRK08258
enoyl-CoA hydratase family protein;
19-138 4.77e-06

enoyl-CoA hydratase family protein;


Pssm-ID: 181329  Cd Length: 277  Bit Score: 44.57  E-value: 4.77e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119568488  19 GKILLGLSRLPLISVALVQGWALGGGAEFTTACDFRLMTPESKIRFVHKEMGIIPS-WGGTTRLVEIIGSRQALKVLSGA 97
Cdd:PRK08258 103 GDLVKAMRACPQPIIAAVDGVCAGAGAILAMASDLRLGTPSAKTAFLFTRVGLAGAdMGACALLPRIIGQGRASELLYTG 182

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 119568488  98 LKLDSKNALNIGMVEEVLQSSDetkSLEEAQEWLKQFIQGP 138
Cdd:PRK08258 183 RSMSAEEGERWGFFNRLVEPEE---LLAEAQALARRLAAGP 220
PRK08140 PRK08140
enoyl-CoA hydratase; Provisional
 25-148 1.21e-05

enoyl-CoA hydratase; Provisional


Pssm-ID: 236163  Cd Length: 262  Bit Score: 43.36  E-value: 1.21e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119568488  25 LSRLPLISVALVQGWALGGGAEFTTACDFRLMTPESKirFVHK--EMGIIPSWGGTTRLVEIIGSRQALKVLSGALKLDS 102
Cdd:PRK08140  95 LRALPLPVIAAVNGVAAGAGANLALACDIVLAARSAS--FIQAfvKIGLVPDSGGTWFLPRLVGMARALGLALLGEKLSA 172

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 119568488 103 KNALNIGMVEEVLqssDETKSLEEAQEWLKQFIQGPPEVIRALKKS 148
Cdd:PRK08140 173 EQAEQWGLIWRVV---DDAALADEAQQLAAHLATQPTRGLALIKQA 215
PLN02921 PLN02921
naphthoate synthase
 27-148 1.21e-05

naphthoate synthase


Pssm-ID: 178509 [Multi-domain]  Cd Length: 327  Bit Score: 43.62  E-value: 1.21e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119568488  27 RLPLISVALVQGWALGGGAEFTTACDFRLMTPESKIRFVHKEMGIIPSWGGTTRLVEIIGSRQALKVLSGALKLDSKNAL 106
Cdd:PLN02921 159 RLPKPVIAMVAGYAVGGGHILHMVCDLTIAADNAVFGQTGPKVGSFDAGYGSSIMARLVGQKKAREMWFLARFYTASEAL 238

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 119568488 107 NIGMVEEVLQSSDetksLE-EAQEWLKQFIQGPPEVIRALKKS 148
Cdd:PLN02921 239 KMGLVNTVVPLDE----LEgETVKWCREILRNSPTAIRVLKSA 277
PRK05995 PRK05995
enoyl-CoA hydratase; Provisional
 25-149 1.38e-05

enoyl-CoA hydratase; Provisional


Pssm-ID: 235664 [Multi-domain]  Cd Length: 262  Bit Score: 43.38  E-value: 1.38e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119568488  25 LSRLPLISVALVQGWALGGGAEFTTACDF-------RLMTPESKIrfvhkemGIIPSwggtT---RLVEIIGSRQALKVL 94
Cdd:PRK05995  95 IYRCPKPVIARVHGDAYAGGMGLVAACDIavaadhaVFCLSEVRL-------GLIPA----TispYVIRAMGERAARRYF 163

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 119568488  95 SGALKLDSKNALNIGMVEEVLqSSDEtksLEEAQEWL-KQFIQGPPEVIRALKKSV 149
Cdd:PRK05995 164 LTAERFDAAEALRLGLVHEVV-PAEA---LDAKVDELlAALVANSPQAVRAGKRLV 215
PRK08788 PRK08788
enoyl-CoA hydratase; Validated
 28-98 1.74e-05

enoyl-CoA hydratase; Validated


Pssm-ID: 236338  Cd Length: 287  Bit Score: 42.98  E-value: 1.74e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 119568488  28 LPLISVALVQGWALGGGAEFTTACDF-------RLMTPEskIRFvhkemGIIPSWGGTTRLVEIIGSRQALK-VLSGAL 98
Cdd:PRK08788 120 AGAISIALVQGDALGGGFEAALSHHTiiaergaKMGFPE--ILF-----NLFPGMGAYSFLARRVGPKLAEElILSGKL 191
PRK07799 PRK07799
crotonase/enoyl-CoA hydratase family protein;
27-149 3.77e-05

crotonase/enoyl-CoA hydratase family protein;


Pssm-ID: 181122 [Multi-domain]  Cd Length: 263  Bit Score: 42.01  E-value: 3.77e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119568488  27 RLPLIsvALVQGWALGGGAEFTTACDFRLMTPESKIRFVHKEMGIIPSWGGTTRLVEIIGSRQALKVLSGALKLDSKNAL 106
Cdd:PRK07799 100 TKPLI--AAVEGPAIAGGTEILQGTDIRVAGESAKFGISEAKWSLFPMGGSAVRLVRQIPYTVACDLLLTGRHITAAEAK 177

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 119568488 107 NIGMVEEVLqssDETKSLEEAQEWLKQFIQGPPEVIRALKKSV 149
Cdd:PRK07799 178 EIGLIGHVV---PDGQALDKALELAELINANGPLAVQAILRTI 217
PRK08252 PRK08252
crotonase/enoyl-CoA hydratase family protein;
19-149 9.47e-05

crotonase/enoyl-CoA hydratase family protein;


Pssm-ID: 181325 [Multi-domain]  Cd Length: 254  Bit Score: 40.74  E-value: 9.47e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119568488  19 GKILLGLS----RLPLIsvALVQGWALGGGAEFTTACDFRLMTPESKIRFVHKEMGIIPSWGGTTRLVEIIGSRQALK-V 93
Cdd:PRK08252  79 GRGFGGLTerppRKPLI--AAVEGYALAGGFELALACDLIVAARDAKFGLPEVKRGLVAAGGGLLRLPRRIPYHIAMElA 156

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 119568488  94 LSGALkLDSKNALNIGMVEEVlqsSDETKSLEEAQEWLKQFIQGPPEVIRALKKSV 149
Cdd:PRK08252 157 LTGDM-LTAERAHELGLVNRL---TEPGQALDAALELAERIAANGPLAVAASKRIV 208
PRK08259 PRK08259
crotonase/enoyl-CoA hydratase family protein;
23-149 4.25e-04

crotonase/enoyl-CoA hydratase family protein;


Pssm-ID: 236205  Cd Length: 254  Bit Score: 39.11  E-value: 4.25e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119568488  23 LGLSRL----PLIsvALVQGWALGGGAEFTTACDFRLMTPESKI-----RFvhkemGIIPSWGGTTRLVEIIGSRQALK- 92
Cdd:PRK08259  85 MGPSRMrlskPVI--AAVSGYAVAGGLELALWCDLRVAEEDAVFgvfcrRW-----GVPLIDGGTVRLPRLIGHSRAMDl 157

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 119568488  93 VLSGAlKLDSKNALNIGMVEEVLQSSDetkSLEEAQEWLKQFIQGPPEVIRALKKSV 149
Cdd:PRK08259 158 ILTGR-PVDADEALAIGLANRVVPKGQ---ARAAAEELAAELAAFPQTCLRADRLSA 210
PRK06210 PRK06210
enoyl-CoA hydratase; Provisional
 27-119 4.82e-04

enoyl-CoA hydratase; Provisional


Pssm-ID: 180472  Cd Length: 272  Bit Score: 38.92  E-value: 4.82e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119568488  27 RLPLIsvALVQGWALGGGAEFTTACDFRLMTPESKIRFVHKEMGIIPSWGGTTRLVEIIGSRQALKVLSGALKLDSKNAL 106
Cdd:PRK06210 108 RKPVI--AAINGACAGIGLTHALMCDVRFAADGAKFTTAFARRGLIAEHGISWILPRLVGHANALDLLLSARTFYAEEAL 185

                         90
                 ....*....|...
gi 119568488 107 NIGMVEEVLQSSD 119
Cdd:PRK06210 186 RLGLVNRVVPPDE 198
PRK08150 PRK08150
crotonase/enoyl-CoA hydratase family protein;
27-129 5.36e-04

crotonase/enoyl-CoA hydratase family protein;


Pssm-ID: 181254  Cd Length: 255  Bit Score: 38.46  E-value: 5.36e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119568488  27 RLPLISvALvQGWALGGGAEFTTACDFRLMTPESKIRFVHKEMGIIPSWGGTTRLVEIIG-SRQALKVLSGALkLDSKNA 105
Cdd:PRK08150  92 RVPVIA-AL-HGAVVGGGLELASAAHIRVADESTYFALPEGQRGIFVGGGGSVRVPRLIGvARMTDMMLTGRV-YDAQEG 168

                         90       100
                 ....*....|....*....|....
gi 119568488 106 LNIGMVEEVLQSSdetKSLEEAQE 129
Cdd:PRK08150 169 ERLGLAQYLVPAG---EALDKAME 189
PRK05864 PRK05864
enoyl-CoA hydratase; Provisional
 21-111 6.88e-04

enoyl-CoA hydratase; Provisional


Pssm-ID: 168278 [Multi-domain]  Cd Length: 276  Bit Score: 38.28  E-value: 6.88e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119568488  21 ILLGLSRLPLISVALVQGWALGGGAEFTTACDFRLMTPESKIRFVHKEMGIIPSWGGTTRLV-EIIGSRQALKVLSGALK 99
Cdd:PRK05864 101 VILALRRLHQPVIAAVNGPAIGGGLCLALAADIRVASSSAYFRAAGINNGLTASELGLSYLLpRAIGSSRAFEIMLTGRD 180

                         90
                 ....*....|..
gi 119568488 100 LDSKNALNIGMV 111
Cdd:PRK05864 181 VDAEEAERIGLV 192
PRK07468 PRK07468
crotonase/enoyl-CoA hydratase family protein;
22-129 6.75e-03

crotonase/enoyl-CoA hydratase family protein;


Pssm-ID: 180987 [Multi-domain]  Cd Length: 262  Bit Score: 35.42  E-value: 6.75e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119568488  22 LLGLSRLPLISVALVQGWALGGGAEFTTACDFRLMTPESKIRFVHKEMGIIPSWGGTTrLVEIIGSRQALKVLSGALKLD 101
Cdd:PRK07468  93 LKALNDLPKPLIGRIQGQAFGGGVGLISVCDVAIAVSGARFGLTETRLGLIPATISPY-VVARMGEANARRVFMSARLFD 171

                         90       100
                 ....*....|....*....|....*...
gi 119568488 102 SKNALNIGMVEEVLQSSDetksLEEAQE 129
Cdd:PRK07468 172 AEEAVRLGLLSRVVPAER----LDAAVE 195
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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