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Conserved domains on  [gi|119592983|gb|EAW72577|]
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zinc finger protein 497, isoform CRA_a [Homo sapiens]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11472214)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
167-552 6.71e-19

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 89.75  E-value: 6.71e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119592983 167 RCGECGKAFSQGSYLLQHRRVHTGEKPYTC--PECGKAFAWSSNLSQHQRIHSGEKPYacRECGKAFRAHSQLIHHQETH 244
Cdd:COG5048   35 SCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSD--LNSKSLPLSNSKASSSSLSS 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119592983 245 SGLKPFRCPDC-GKSFGRSTTLVQHRRTHTGEKPYECPecgkaFSWNSNFLEHRRVHTGARP--HACRDCGKAFSQSSNL 321
Cdd:COG5048  113 SSSNSNDNNLLsSHSLPPSSRDPQLPDLLSISNLRNNP-----LPGNNSSSVNTPQSNSLHPplPANSLSKDPSSNLSLL 187

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119592983 322 AeHLKIHAGARPHACPDCGKAFVRVAGLRQHRRTHSSEKPFPCAECGKAFRESSQLLQHQRTHTGERPFECAECGQAfvM 401
Cdd:COG5048  188 I-SSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRS--S 264

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119592983 402 GSYLAEHRRVHTG---------EKPHACAQCGKAFSQRSNLLSHRRT--HSG--AKPFAC--ADCGKAF-RGSSGLAHHR 465
Cdd:COG5048  265 LPTASSQSSSPNEsdsssekgfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGesLKPFSCpySLCGKLFsRNDALKRHIL 344

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119592983 466 LsHTGERPFAC--AECGKAFRGSSELRQHQRLH-----SGERPFVCAH--CSKAFVRKSELLSHRRTHTGERPYAC--GE 534
Cdd:COG5048  345 L-HTSISPAKEklLNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETLSnsCIRNFKRDSNLSLHIITHLSFRPYNCknPP 423

                        410
                 ....*....|....*...
gi 119592983 535 CGKPFSHRCNLNEHQKRH 552
Cdd:COG5048  424 CSKSFNRHYNLIPHKKIH 441
PRK07764 super family cl35613
DNA polymerase III subunits gamma and tau; Validated
 25-164 7.38e-04

DNA polymerase III subunits gamma and tau; Validated


The actual alignment was detected with superfamily member PRK07764:

Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 42.67  E-value: 7.38e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119592983  25 PAPRPQEELVPRTEEGEEQEAPLGPFQAPPPGHRREmESPRGWTLQVAPEEGQVLCNVKTATRGLSEGAVSGGWGAWEN- 103
Cdd:PRK07764 603 PASSGPPEEAARPAAPAAPAAPAAPAPAGAAAAPAE-ASAAPAPGVAAPEHHPKHVAVPDASDGGDGWPAKAGGAAPAAp 681

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 119592983 104 ---STEVPREAGDGQRQQATLGAADEQGGPGRELGPADGGRDGAGPRSEPADRALRPSPLPEEP 164
Cdd:PRK07764 682 ppaPAPAAPAAPAGAAPAQPAPAPAATPPAGQADDPAAQPPQAAQGASAPSPAADDPVPLPPEP 745
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
167-552 6.71e-19

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 89.75  E-value: 6.71e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119592983 167 RCGECGKAFSQGSYLLQHRRVHTGEKPYTC--PECGKAFAWSSNLSQHQRIHSGEKPYacRECGKAFRAHSQLIHHQETH 244
Cdd:COG5048   35 SCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSD--LNSKSLPLSNSKASSSSLSS 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119592983 245 SGLKPFRCPDC-GKSFGRSTTLVQHRRTHTGEKPYECPecgkaFSWNSNFLEHRRVHTGARP--HACRDCGKAFSQSSNL 321
Cdd:COG5048  113 SSSNSNDNNLLsSHSLPPSSRDPQLPDLLSISNLRNNP-----LPGNNSSSVNTPQSNSLHPplPANSLSKDPSSNLSLL 187

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119592983 322 AeHLKIHAGARPHACPDCGKAFVRVAGLRQHRRTHSSEKPFPCAECGKAFRESSQLLQHQRTHTGERPFECAECGQAfvM 401
Cdd:COG5048  188 I-SSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRS--S 264

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119592983 402 GSYLAEHRRVHTG---------EKPHACAQCGKAFSQRSNLLSHRRT--HSG--AKPFAC--ADCGKAF-RGSSGLAHHR 465
Cdd:COG5048  265 LPTASSQSSSPNEsdsssekgfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGesLKPFSCpySLCGKLFsRNDALKRHIL 344

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119592983 466 LsHTGERPFAC--AECGKAFRGSSELRQHQRLH-----SGERPFVCAH--CSKAFVRKSELLSHRRTHTGERPYAC--GE 534
Cdd:COG5048  345 L-HTSISPAKEklLNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETLSnsCIRNFKRDSNLSLHIITHLSFRPYNCknPP 423

                        410
                 ....*....|....*...
gi 119592983 535 CGKPFSHRCNLNEHQKRH 552
Cdd:COG5048  424 CSKSFNRHYNLIPHKKIH 441
zf-H2C2_2 pfam13465
Zinc-finger double domain;
265-288 2.17e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.20  E-value: 2.17e-05
                          10        20
                  ....*....|....*....|....
gi 119592983  265 LVQHRRTHTGEKPYECPECGKAFS 288
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
PHA00733 PHA00733
hypothetical protein
 193-240 5.25e-04

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 40.24  E-value: 5.25e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 119592983 193 PYTCPECGKAFAWSSNLSQHqrIHSGEKPYACRECGKAFRAHSQLIHH 240
Cdd:PHA00733  73 PYVCPLCLMPFSSSVSLKQH--IRYTEHSKVCPVCGKEFRNTDSTLDH 118
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 25-164 7.38e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 42.67  E-value: 7.38e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119592983  25 PAPRPQEELVPRTEEGEEQEAPLGPFQAPPPGHRREmESPRGWTLQVAPEEGQVLCNVKTATRGLSEGAVSGGWGAWEN- 103
Cdd:PRK07764 603 PASSGPPEEAARPAAPAAPAAPAAPAPAGAAAAPAE-ASAAPAPGVAAPEHHPKHVAVPDASDGGDGWPAKAGGAAPAAp 681

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 119592983 104 ---STEVPREAGDGQRQQATLGAADEQGGPGRELGPADGGRDGAGPRSEPADRALRPSPLPEEP 164
Cdd:PRK07764 682 ppaPAPAAPAAPAGAAPAQPAPAPAATPPAGQADDPAAQPPQAAQGASAPSPAADDPVPLPPEP 745
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
167-552 6.71e-19

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 89.75  E-value: 6.71e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119592983 167 RCGECGKAFSQGSYLLQHRRVHTGEKPYTC--PECGKAFAWSSNLSQHQRIHSGEKPYacRECGKAFRAHSQLIHHQETH 244
Cdd:COG5048   35 SCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSD--LNSKSLPLSNSKASSSSLSS 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119592983 245 SGLKPFRCPDC-GKSFGRSTTLVQHRRTHTGEKPYECPecgkaFSWNSNFLEHRRVHTGARP--HACRDCGKAFSQSSNL 321
Cdd:COG5048  113 SSSNSNDNNLLsSHSLPPSSRDPQLPDLLSISNLRNNP-----LPGNNSSSVNTPQSNSLHPplPANSLSKDPSSNLSLL 187

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119592983 322 AeHLKIHAGARPHACPDCGKAFVRVAGLRQHRRTHSSEKPFPCAECGKAFRESSQLLQHQRTHTGERPFECAECGQAfvM 401
Cdd:COG5048  188 I-SSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRS--S 264

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119592983 402 GSYLAEHRRVHTG---------EKPHACAQCGKAFSQRSNLLSHRRT--HSG--AKPFAC--ADCGKAF-RGSSGLAHHR 465
Cdd:COG5048  265 LPTASSQSSSPNEsdsssekgfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGesLKPFSCpySLCGKLFsRNDALKRHIL 344

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119592983 466 LsHTGERPFAC--AECGKAFRGSSELRQHQRLH-----SGERPFVCAH--CSKAFVRKSELLSHRRTHTGERPYAC--GE 534
Cdd:COG5048  345 L-HTSISPAKEklLNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETLSnsCIRNFKRDSNLSLHIITHLSFRPYNCknPP 423

                        410
                 ....*....|....*...
gi 119592983 535 CGKPFSHRCNLNEHQKRH 552
Cdd:COG5048  424 CSKSFNRHYNLIPHKKIH 441
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
184-464 2.38e-14

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 75.50  E-value: 2.38e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119592983 184 HRRVHTGEKPYTCPECGKAFAWSSNLSQHQRIHSGEKPYACRECGKAFRAHSQLIHHQETHSGLKPFRCPDCGKSfgrST 263
Cdd:COG5048  189 SSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRS---SL 265

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119592983 264 TLVQHRRTHtgekpyecpecgkafSWNSNFLEHRRVHTgarPHACRDCGKAFSQSSNLAEHL--KIH--AGARPHACP-- 337
Cdd:COG5048  266 PTASSQSSS---------------PNESDSSSEKGFSL---PIKSKQCNISFSRSSPLTRHLrsVNHsgESLKPFSCPys 327

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119592983 338 DCGKAFVRVAGLRQHRRTHSSEKPFPC--AECGKAFRESS-----QLLQHQRTHTGERPFECA--ECGQAFVMGSYLAEH 408
Cdd:COG5048  328 LCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLnneppQSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLH 407

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 119592983 409 RRVHTGEKPHAC--AQCGKAFSQRSNLLSHRRTHSGAKPFACADCGKaFRGSSGLAHH 464
Cdd:COG5048  408 IITHLSFRPYNCknPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS-FRRDLDLSNH 464
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
166-280 8.08e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.54  E-value: 8.08e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119592983 166 CRCGECGKAFSQGSYLLQHRR--VHTGE--KPYTCPE--CGKAFAWSSNLSQHQRIHSGEKPYAC--RECGKAFR----- 232
Cdd:COG5048  290 IKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSpllnn 369

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119592983 233 AHSQLIHHQETHSGLKP--------------------------------FRCPDCGKSFGRSTTLVQHRRTHTGEKPYEC 280
Cdd:COG5048  370 EPPQSLQQYKDLKNDKKsetlsnscirnfkrdsnlslhiithlsfrpynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLC 449
zf-H2C2_2 pfam13465
Zinc-finger double domain;
265-288 2.17e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.20  E-value: 2.17e-05
                          10        20
                  ....*....|....*....|....
gi 119592983  265 LVQHRRTHTGEKPYECPECGKAFS 288
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
180-204 6.64e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.05  E-value: 6.64e-05
                          10        20
                  ....*....|....*....|....*
gi 119592983  180 YLLQHRRVHTGEKPYTCPECGKAFA 204
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
208-231 9.00e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.66  E-value: 9.00e-05
                          10        20
                  ....*....|....*....|....
gi 119592983  208 NLSQHQRIHSGEKPYACRECGKAF 231
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
404-429 2.95e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 2.95e-04
                          10        20
                  ....*....|....*....|....*.
gi 119592983  404 YLAEHRRVHTGEKPHACAQCGKAFSQ 429
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 274-357 3.15e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.17  E-value: 3.15e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119592983 274 GEKPYECP--ECGKAFSwNSNFLEHRRVHTgarpHacrdCGKAFSQSSNLAEHLKIHAGARPHACPDCGKAFVRVAGLRQ 351
Cdd:COG5189  346 DGKPYKCPveGCNKKYK-NQNGLKYHMLHG----H----QNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ....*.
gi 119592983 352 HrRTHS 357
Cdd:COG5189  417 H-RKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
349-371 4.04e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 4.04e-04
                          10        20
                  ....*....|....*....|...
gi 119592983  349 LRQHRRTHSSEKPFPCAECGKAF 371
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
PHA00733 PHA00733
hypothetical protein
 193-240 5.25e-04

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 40.24  E-value: 5.25e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 119592983 193 PYTCPECGKAFAWSSNLSQHqrIHSGEKPYACRECGKAFRAHSQLIHH 240
Cdd:PHA00733  73 PYVCPLCLMPFSSSVSLKQH--IRYTEHSKVCPVCGKEFRNTDSTLDH 118
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 25-164 7.38e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 42.67  E-value: 7.38e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119592983  25 PAPRPQEELVPRTEEGEEQEAPLGPFQAPPPGHRREmESPRGWTLQVAPEEGQVLCNVKTATRGLSEGAVSGGWGAWEN- 103
Cdd:PRK07764 603 PASSGPPEEAARPAAPAAPAAPAAPAPAGAAAAPAE-ASAAPAPGVAAPEHHPKHVAVPDASDGGDGWPAKAGGAAPAAp 681

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 119592983 104 ---STEVPREAGDGQRQQATLGAADEQGGPGRELGPADGGRDGAGPRSEPADRALRPSPLPEEP 164
Cdd:PRK07764 682 ppaPAPAAPAAPAGAAPAQPAPAPAATPPAGQADDPAAQPPQAAQGASAPSPAADDPVPLPPEP 745
zf-H2C2_2 pfam13465
Zinc-finger double domain;
377-400 9.48e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 9.48e-04
                          10        20
                  ....*....|....*....|....
gi 119592983  377 LLQHQRTHTGERPFECAECGQAFV 400
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
416-509 1.28e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.61  E-value: 1.28e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119592983 416 KPHACAQCGKAFSQRSNLLSHRRTHSGAKPFACADCGkafrgssglahhrlshtgerpfacaeCGKAFRGSSELRQHQRL 495
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSG--------------------------CDKSFSRPLELSRHLRT 85

                         90
                 ....*....|....
gi 119592983 496 HSGERPFVCAHCSK 509
Cdd:COG5048   86 HHNNPSDLNSKSLP 99
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 250-272 1.64e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.12  E-value: 1.64e-03
                          10        20
                  ....*....|....*....|...
gi 119592983  250 FRCPDCGKSFGRSTTLVQHRRTH 272
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 185-273 3.10e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.09  E-value: 3.10e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119592983 185 RRVHTGEKPYTCP--ECGKAFAWSSNLSQHqRIHSgekpyacrECGKAFRAHSQLIHHQETHSGLKPFRCPDCGKSFGRS 262
Cdd:COG5189  341 MLKVKDGKPYKCPveGCNKKYKNQNGLKYH-MLHG--------HQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNL 411

                         90
                 ....*....|.
gi 119592983 263 TTLVQHrRTHT 273
Cdd:COG5189  412 NGLKYH-RKHS 421
PHA00733 PHA00733
hypothetical protein
 249-296 3.91e-03

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 37.55  E-value: 3.91e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 119592983 249 PFRCPDCGKSFGRSTTLVQHRRTHTGEKpyECPECGKAFSWNSNFLEH 296
Cdd:PHA00733  73 PYVCPLCLMPFSSSVSLKQHIRYTEHSK--VCPVCGKEFRNTDSTLDH 118
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 418-440 6.66e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.20  E-value: 6.66e-03
                          10        20
                  ....*....|....*....|...
gi 119592983  418 HACAQCGKAFSQRSNLLSHRRTH 440
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
PHA00733 PHA00733
hypothetical protein
 333-380 6.75e-03

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 37.16  E-value: 6.75e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 119592983 333 PHACPDCGKAFVRVAGLRQHRR--THSSEkpfpCAECGKAFRESSQLLQH 380
Cdd:PHA00733  73 PYVCPLCLMPFSSSVSLKQHIRytEHSKV----CPVCGKEFRNTDSTLDH 118
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 502-524 6.80e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.20  E-value: 6.80e-03
                          10        20
                  ....*....|....*....|...
gi 119592983  502 FVCAHCSKAFVRKSELLSHRRTH 524
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 362-384 6.86e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.20  E-value: 6.86e-03
                          10        20
                  ....*....|....*....|...
gi 119592983  362 FPCAECGKAFRESSQLLQHQRTH 384
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
432-455 7.17e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 7.17e-03
                          10        20
                  ....*....|....*....|....
gi 119592983  432 NLLSHRRTHSGAKPFACADCGKAF 455
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
516-541 8.65e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.88  E-value: 8.65e-03
                          10        20
                  ....*....|....*....|....*.
gi 119592983  516 ELLSHRRTHTGERPYACGECGKPFSH 541
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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