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Conserved domains on  [gi|119594661|gb|EAW74255|]
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hCG1775361, partial [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HkD_Gipie cd22230
Hook domain found in Gipie (GRP78-interacting protein induced by ER stress) and similar ...
 10-180 8.37e-87

Hook domain found in Gipie (GRP78-interacting protein induced by ER stress) and similar proteins; Gipie, also called coiled-coil domain-containing protein 88B (CCDC88B), or brain leucine zipper domain-containing protein, or Hook-related protein 3 (HkRP3), is a novel actin cytoskeleton-binding protein and Akt substrate that regulates cell migratory responses in various biological contexts. It acts as a positive regulator of T-cell maturation and inflammatory function. As a microtubule-binding protein, Gipie regulates lytic granule clustering and NK cell killing.


:

Pssm-ID: 411801  Cd Length: 170  Bit Score: 253.21  E-value: 8.37e-87
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119594661  10 RDFLSGSLATWALGLAGLVGEAEDSEGEEEEEEEEPPLWLEKRFLRLSDGALLLRVLGIIAPSSRGGPRMlRGLDGPAAW 89
Cdd:cd22230    1 EEFMSGALVTWALGFEGLVGEEEDSLGFPEEEEEEGTLDAEKRFLRLSNGDLLNRVMGIIDPSPRGGPRM-RGDDGPAAH 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119594661  90 RVWNLNHLWGRLRDFYQEELQLLILSPPPDLQTLGFDPLSEEAVEQLEGVLRLLLGASVQCEHRELFIRHIQGLSLEVQS 169
Cdd:cd22230   80 RVQNLHILWGRLRDFYQEELQQLILSPPPDLQVMGRDPFTEEAVQELEKLLRLLLGAAVQCERRELFIRHIQGLDLDVQA 159

                        170
                 ....*....|.
gi 119594661 170 ELAAAIQEVTQ 180
Cdd:cd22230  160 ELAEAIQEVTQ 170
 
Name Accession Description Interval E-value
HkD_Gipie cd22230
Hook domain found in Gipie (GRP78-interacting protein induced by ER stress) and similar ...
 10-180 8.37e-87

Hook domain found in Gipie (GRP78-interacting protein induced by ER stress) and similar proteins; Gipie, also called coiled-coil domain-containing protein 88B (CCDC88B), or brain leucine zipper domain-containing protein, or Hook-related protein 3 (HkRP3), is a novel actin cytoskeleton-binding protein and Akt substrate that regulates cell migratory responses in various biological contexts. It acts as a positive regulator of T-cell maturation and inflammatory function. As a microtubule-binding protein, Gipie regulates lytic granule clustering and NK cell killing.


Pssm-ID: 411801  Cd Length: 170  Bit Score: 253.21  E-value: 8.37e-87
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119594661  10 RDFLSGSLATWALGLAGLVGEAEDSEGEEEEEEEEPPLWLEKRFLRLSDGALLLRVLGIIAPSSRGGPRMlRGLDGPAAW 89
Cdd:cd22230    1 EEFMSGALVTWALGFEGLVGEEEDSLGFPEEEEEEGTLDAEKRFLRLSNGDLLNRVMGIIDPSPRGGPRM-RGDDGPAAH 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119594661  90 RVWNLNHLWGRLRDFYQEELQLLILSPPPDLQTLGFDPLSEEAVEQLEGVLRLLLGASVQCEHRELFIRHIQGLSLEVQS 169
Cdd:cd22230   80 RVQNLHILWGRLRDFYQEELQQLILSPPPDLQVMGRDPFTEEAVQELEKLLRLLLGAAVQCERRELFIRHIQGLDLDVQA 159

                        170
                 ....*....|.
gi 119594661 170 ELAAAIQEVTQ 180
Cdd:cd22230  160 ELAEAIQEVTQ 170
HOOK_N pfam19047
HOOK domain; This domain is found at the N-terminus of HOOK proteins.
 56-178 1.98e-08

HOOK domain; This domain is found at the N-terminus of HOOK proteins.


Pssm-ID: 465958  Cd Length: 151  Bit Score: 51.25  E-value: 1.98e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119594661   56 LSDGALLLRVLGIIAPSSRGGPRMLRGLDGPAA-WR--VWNLNHLWGRLRDFYQEELQLLILSPP-PDLQTLG--FDPls 129
Cdd:pfam19047  25 LTDGVAMAQVLHQIDPSWFTEAWLSRIKEDVGDnWRlkVSNLKKILQSVVDYYQDVLGQQISDFLlPDVNLIGehSDP-- 102

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 119594661  130 eeavEQLEGVLRLLLGASVQCEHRELFIRHIQGLSLEVQSELAAAIQEV 178
Cdd:pfam19047 103 ----AELGRLLQLILGCAVNCEKKQEYIQQIMTLEESVQHVVMTAIQEL 147
 
Name Accession Description Interval E-value
HkD_Gipie cd22230
Hook domain found in Gipie (GRP78-interacting protein induced by ER stress) and similar ...
 10-180 8.37e-87

Hook domain found in Gipie (GRP78-interacting protein induced by ER stress) and similar proteins; Gipie, also called coiled-coil domain-containing protein 88B (CCDC88B), or brain leucine zipper domain-containing protein, or Hook-related protein 3 (HkRP3), is a novel actin cytoskeleton-binding protein and Akt substrate that regulates cell migratory responses in various biological contexts. It acts as a positive regulator of T-cell maturation and inflammatory function. As a microtubule-binding protein, Gipie regulates lytic granule clustering and NK cell killing.


Pssm-ID: 411801  Cd Length: 170  Bit Score: 253.21  E-value: 8.37e-87
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119594661  10 RDFLSGSLATWALGLAGLVGEAEDSEGEEEEEEEEPPLWLEKRFLRLSDGALLLRVLGIIAPSSRGGPRMlRGLDGPAAW 89
Cdd:cd22230    1 EEFMSGALVTWALGFEGLVGEEEDSLGFPEEEEEEGTLDAEKRFLRLSNGDLLNRVMGIIDPSPRGGPRM-RGDDGPAAH 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119594661  90 RVWNLNHLWGRLRDFYQEELQLLILSPPPDLQTLGFDPLSEEAVEQLEGVLRLLLGASVQCEHRELFIRHIQGLSLEVQS 169
Cdd:cd22230   80 RVQNLHILWGRLRDFYQEELQQLILSPPPDLQVMGRDPFTEEAVQELEKLLRLLLGAAVQCERRELFIRHIQGLDLDVQA 159

                        170
                 ....*....|.
gi 119594661 170 ELAAAIQEVTQ 180
Cdd:cd22230  160 ELAEAIQEVTQ 170
HkD_HkRP cd22223
Hook domain found in the Hook-related protein (HkRP) family; The HkRP family includes Daple, ...
 12-180 3.28e-54

Hook domain found in the Hook-related protein (HkRP) family; The HkRP family includes Daple, Girdin and Gipie. Daple, also called Dvl-associating protein with a high frequency of leucine residues, or coiled-coil domain-containing protein 88C (CCDC88C), or Hook-related protein 2 (HkRP2), is a novel non-receptor nucleotide exchange factor (GEF) required for activation of guanine nucleotide-binding proteins (G-proteins) during non-canonical Wnt signaling. Girdin, also called Akt phosphorylation enhancer (APE), or coiled-coil domain-containing protein 88A (CCDC88A), or G alpha-interacting vesicle-associated protein (GIV), or Girders of actin filament, or Hook-related protein 1 (HkRP1), is a bifunctional modulator of guanine nucleotide-binding proteins (G proteins). It acts as a non-receptor guanine nucleotide exchange factor which binds to and activates guanine nucleotide-binding protein G(i) alpha subunits. It also acts as a guanine nucleotide dissociation inhibitor for guanine nucleotide-binding protein G(s) subunit alpha GNAS. In addition, Girdin plays an essential role in cell migration. Gipie, also called GRP78-interacting protein induced by ER stress, or coiled-coil domain-containing protein 88B (CCDC88B), or brain leucine zipper domain-containing protein, or Hook-related protein 3 (HkRP3), is a novel actin cytoskeleton-binding protein and Akt substrate that regulates cell migratory responses in various biological contexts. It acts as a positive regulator of T-cell maturation and inflammatory function. As a microtubule-binding protein, Gipie regulates lytic granule clustering and NK cell killing. All family members contain a conserved globular Hook domain which folds as a variant of the helical calponin homology (CH) domain.


Pssm-ID: 411794  Cd Length: 149  Bit Score: 169.69  E-value: 3.28e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119594661  12 FLSGSLATWALGLAGLVGeaedsegeeeeeeeepplwLEKRFLRLSDGALLLRVLGIIAPSSRGGPRMlRGLDGPAAWRV 91
Cdd:cd22223    1 FLSSPLVTWAKTFADDGS-------------------AELSYTDLVDGVFLNNVMLQIDPRPFSEVSN-RNVDDDVNARI 60

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119594661  92 WNLNHLWGRLRDFYQEELQLLILSPPPDLQTLGFDPLSEEAVEQLEGVLRLLLGASVQCEHRELFIRHIQGLSLEVQSEL 171
Cdd:cd22223   61 QNLDLLLRNIKSFYQEVLQQLIVMKLPDILTIGREPESEQSLEELEKLLLLLLGCAVQCERKEEFIERIKNLDLEVQHAL 140


                 ....*....
gi 119594661 172 AAAIQEVTQ 180
Cdd:cd22223  141 VACIQEVTD 149
HkD_Girdin cd22229
Hook domain found in Girdin and similar proteins; Girdin, also called Akt phosphorylation ...
 53-180 1.41e-26

Hook domain found in Girdin and similar proteins; Girdin, also called Akt phosphorylation enhancer (APE), or coiled-coil domain-containing protein 88A (CCDC88A), or G alpha-interacting vesicle-associated protein (GIV), or Girders of actin filament, or Hook-related protein 1 (HkRP1), is a bifunctional modulator of guanine nucleotide-binding proteins (G proteins). It acts as a non-receptor guanine nucleotide exchange factor which binds to and activates guanine nucleotide-binding protein G(i) alpha subunits. It also acts as a guanine nucleotide dissociation inhibitor for guanine nucleotide-binding protein G(s) subunit alpha GNAS. In addition, Girdin plays an essential role in cell migration.


Pssm-ID: 411800  Cd Length: 156  Bit Score: 99.09  E-value: 1.41e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119594661  53 FLRLSDGALLLRVLGIIAPSSRGgPRMLRGLDGPAAWRVWNLNHLWGRLRDFYQEELQLLILSPPPDLQTLGFDPLSEEA 132
Cdd:cd22229   30 YVALVDGVFLNEVMLQINPKSSN-QRVNKKVNNDASLRIQNLSILVKQIKLYYQETLQQLIMMSLPNVLVLGRNPLSEQG 108

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 119594661 133 VEQLEGVLRLLLGASVQCEHRELFIRHIQGLSLEVQSELAAAIQEVTQ 180
Cdd:cd22229  109 TEEMKKLLLLLLGCAVQCERKEEFIERIQTLDFDTKAAVAAHIQEVTH 156
HkD_Daple cd22228
Hook domain found in Daple (Dvl-associating protein with a high frequency of leucine residues) ...
 53-180 3.63e-23

Hook domain found in Daple (Dvl-associating protein with a high frequency of leucine residues) and similar proteins; Protein Daple, also called coiled-coil domain-containing protein 88C (CCDC88C), or Hook-related protein 2 (HkRP2), is a novel non-receptor nucleotide exchange factor (GEF) required for activation of guanine nucleotide-binding proteins (G-proteins) during non-canonical Wnt signaling.


Pssm-ID: 411799  Cd Length: 153  Bit Score: 90.37  E-value: 3.63e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119594661  53 FLRLSDGALLLRVLGIIAPSSRGgPRMLRGLDGPAAWRVWNLNHLWGRLRDFYQEELQLLILSPPPDLQTLGFDPLSEEA 132
Cdd:cd22228   27 YMDLVDGVFLNKIMLQIDPRPTN-QRVNKHVNNDVNLRIQNLTILVRHIKTYYQEVLQQLIVMNLPNVLMIGKDPLSGKS 105

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 119594661 133 VEQLEGVLRLLLGASVQCEHRELFIRHIQGLSLEVQSELAAAIQEVTQ 180
Cdd:cd22228  106 MEEIKKMLLLVLGCAVQCERKEEFIERIKQLDIETQAAIVSHIQEVTH 153
HkD_SF cd22211
Hook domain-containing proteins superfamily; The Hook domain superfamily includes Hook adaptor ...
 56-180 9.53e-22

Hook domain-containing proteins superfamily; The Hook domain superfamily includes Hook adaptor proteins, Hook-related proteins and nuclear mitotic apparatus protein (NuMA). They share an N-terminal conserved globular Hook domain, which folds as a variant of the helical calponin homology (CH) domain with an extended alpha-helix. The Hook domain is responsible for the binding of microtubule. The Hook family includes microtubule-binding proteins, Hook1-3. Hook1 is required for spermatid differentiation. Hook2 contributes to the establishment and maintenance of centrosome function. Hook3 is an adaptor protein for microtubule-dependent intracellular vesicle and protein trafficking, and is involved in Golgi and endosome transport. Hook proteins are components of the FTS/Hook/FHIP complex (FHF complex), which may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting (HOPS) complex. The Hook-related protein (HkRP) family includes Daple, Girdin and Gipie. Daple, also called Dvl-associating protein with a high frequency of leucine residues, or coiled-coil domain-containing protein 88C(CCDC88C), or Hook-related protein 2 (HkRP2), is a novel non-receptor nucleotide exchange factor (GEF) required for activation of guanine nucleotide-binding proteins (G-proteins) during non-canonical Wnt signaling. Girdin, also called Akt phosphorylation enhancer (APE), or coiled-coil domain-containing protein 88A (CCDC88A), or G alpha-interacting vesicle-associated protein (GIV), or Girders of actin filament, or Hook-related protein 1 (HkRP1), is a bifunctional modulator of guanine nucleotide-binding proteins (G proteins). Gipie, also called GRP78-interacting protein induced by ER stress, or coiled-coil domain-containing protein 88B(CCDC88B), or brain leucine zipper domain-containing protein, or Hook-related protein 3 (HkRP3), is a novel actin cytoskeleton-binding protein and Akt substrate that regulates cell migratory responses in various biological contexts. NuMA, also called nuclear mitotic apparatus protein 1, or nuclear matrix protein-22 (NMP-22), or SP-H antigen, is a microtubule (MT)-binding protein that plays a role in the formation and maintenance of the spindle poles and the alignment and the segregation of chromosomes during mitotic cell division.


Pssm-ID: 411792  Cd Length: 145  Bit Score: 86.56  E-value: 9.53e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119594661  56 LSDGALLLRVLGIIAPSSRGGPRmLRGLDGPAAWRV-W-NLNHLWGRLRDFYQEEL-QLLILSPPPDLQTLGFDPlSEEA 132
Cdd:cd22211   23 LSDGVVLAEILSQIDPSYFDSEW-LESRDSSDNWVLkLnNLKKLYRSLSKYYREVLgQQLSDLPLPDLSAIARDG-DEEE 100

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 119594661 133 VEQLegvLRLLLGASVQCEHRELFIRHIQGLSLEVQSELAAAIQEVTQ 180
Cdd:cd22211  101 IVKL---LELVLGAAVQCENKEEYIARIQQLDESTQAELMLIIQEVLE 145
HkD_Hook cd22222
Hook domain found in Hook family of microtubule-binding proteins; The Hook family includes ...
 56-178 4.24e-16

Hook domain found in Hook family of microtubule-binding proteins; The Hook family includes Hook1-3. Hook1 is a microtubule-binding protein required for spermatid differentiation. Hook2, also a microtubule-binding protein, contributes to the establishment and maintenance of centrosome function. It may function in the positioning or formation of aggresomes, which are pericentriolar accumulations of misfolded proteins, proteasomes and chaperones. Hook3 is an adaptor protein for microtubule-dependent intracellular vesicle and protein trafficking. It is involved in Golgi and endosome transport. It acts as a scaffold for the opposite-polarity microtubule-based motors cytoplasmic dynein-1 and the kinesin KIF1C. It may participate in the turnover of the endocytosed scavenger receptor. Hook proteins are components of the FTS/Hook/FHIP complex (FHF complex), which may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting (HOPS) complex. Hook adaptor proteins share an N-terminal conserved globular Hook domain, which folds as a variant of the helical calponin homology (CH) domain, and contacts the helix alpha1 of dynein light intermediate chain 1 (LIC1) in a hydrophobic groove.


Pssm-ID: 411793  Cd Length: 147  Bit Score: 71.51  E-value: 4.24e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119594661  56 LSDGALLLRVLGIIAPSSRGGPRMLRGLDGPAA-WR--VWNLNHLWGRLRDFYQEEL-QLLILSPPPDLQTLGfdplSEE 131
Cdd:cd22222   23 LSDGVAIAQVLNQIDPEYFSDSWLSKIKPDVGDnWRlkVSNLKKILKGIVDYYSEVLgQQISGFTMPDVNAIA----EKE 98

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 119594661 132 AVEQLEGVLRLLLGASVQCEHRELFIRHIQGLSLEVQSELAAAIQEV 178
Cdd:cd22222   99 DPKELGRLLQLVLGCAVNCERKEEYIQAIMGLEESVQHVVMEAIQEL 145
HOOK_N pfam19047
HOOK domain; This domain is found at the N-terminus of HOOK proteins.
 56-178 1.98e-08

HOOK domain; This domain is found at the N-terminus of HOOK proteins.


Pssm-ID: 465958  Cd Length: 151  Bit Score: 51.25  E-value: 1.98e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119594661   56 LSDGALLLRVLGIIAPSSRGGPRMLRGLDGPAA-WR--VWNLNHLWGRLRDFYQEELQLLILSPP-PDLQTLG--FDPls 129
Cdd:pfam19047  25 LTDGVAMAQVLHQIDPSWFTEAWLSRIKEDVGDnWRlkVSNLKKILQSVVDYYQDVLGQQISDFLlPDVNLIGehSDP-- 102

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 119594661  130 eeavEQLEGVLRLLLGASVQCEHRELFIRHIQGLSLEVQSELAAAIQEV 178
Cdd:pfam19047 103 ----AELGRLLQLILGCAVNCEKKQEYIQQIMTLEESVQHVVMTAIQEL 147
HkD_Hook1 cd22225
Hook domain found in protein Hook 1 (Hook1) and similar proteins; Hook1 is a ...
 89-178 1.64e-07

Hook domain found in protein Hook 1 (Hook1) and similar proteins; Hook1 is a microtubule-binding protein required for spermatid differentiation. It is a component of the FTS/Hook/FHIP complex (FHF complex), which may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting (HOPS) complex.


Pssm-ID: 411796  Cd Length: 150  Bit Score: 48.69  E-value: 1.64e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119594661  89 WR--VWNLNHLWGRLRDFYQEELQLLILSPP-PDLQTLG--FDPLseeaveQLEGVLRLLLGASVQCEHRELFIRHIQGL 163
Cdd:cd22225   58 WRikMSNLKKILQGIVDYYHEFLDQQISEFLlPDLNRIAehSDPV------ELGRLLQLILGCAVNCEKKQEHIQNIMTL 131

                         90
                 ....*....|....*
gi 119594661 164 SLEVQSELAAAIQEV 178
Cdd:cd22225  132 EESVQHVVMTAIQEL 146
HkD_Hook3 cd22226
Hook domain found in protein Hook 3 (Hook3) and similar proteins; Hook3 is an adaptor protein ...
 89-178 9.71e-05

Hook domain found in protein Hook 3 (Hook3) and similar proteins; Hook3 is an adaptor protein for microtubule-dependent intracellular vesicle and protein trafficking. It is involved in Golgi and endosome transport. It acts as a scaffold for the opposite-polarity microtubule-based motors cytoplasmic dynein-1 and the kinesin KIF1C. It may participate in the turnover of the endocytosed scavenger receptor. Hook3 is a component of the FTS/Hook/FHIP complex (FHF complex), which may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting (HOPS) complex.


Pssm-ID: 411797  Cd Length: 153  Bit Score: 41.11  E-value: 9.71e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119594661  89 WR--VWNLNHLWGRLRDFYQEEL-QLLILSPPPDLQTLGfdplSEEAVEQLEGVLRLLLGASVQCEHRELFIRHIQGLSL 165
Cdd:cd22226   62 WRlkISNLKKILKGILDYNHEILgQQINDFTLPDVNLIG----EHSDAAELGRMLQLILGCAVNCEQKQEYIQTIMMMEE 137

                         90
                 ....*....|...
gi 119594661 166 EVQSELAAAIQEV 178
Cdd:cd22226  138 SVQHVVMTAIQEL 150
HkD_Hook2 cd22227
Hook domain found in protein Hook 2 (Hook2) and similar proteins; Hook2 is a ...
 56-178 4.38e-04

Hook domain found in protein Hook 2 (Hook2) and similar proteins; Hook2 is a microtubule-binding protein that contributes to the establishment and maintenance of centrosome function. It may function in the positioning or formation of aggresomes, which are pericentriolar accumulations of misfolded proteins, proteasomes and chaperones. Hook2 is a component of the FTS/Hook/FHIP complex (FHF complex), which may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting (HOPS) complex.


Pssm-ID: 411798  Cd Length: 150  Bit Score: 39.09  E-value: 4.38e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119594661  56 LSDGALLLRVLGIIAPSSRGGPRMLRGLDGPAA-WR--VWNLNHLWGRLRDFYQEELQLLILSPP-PDLQTLG-FDPLSE 130
Cdd:cd22227   25 LTSGVAIAQVLNRIDPSWFNEAWLGRIKEDTGDnWRlkVSNLKKILQSLLEYYQDVLGHQVSEDHlPDVNLIGeFSDDTE 104

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 119594661 131 eaveqLEGVLRLLLGASVQCEHRELFIRHIQGLSLEVQSELAAAIQEV 178
Cdd:cd22227  105 -----LGKLLQLVLGCAISCEKKQEHIQQIMTLEESVQHVVMEAIQEL 147
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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