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pyruvate kinase, muscle, isoform CRA_b [Homo sapiens]
Protein Classification
pyruvate kinase ( domain architecture ID 1562468 )
pyruvate kinase catalyzes the phosphorylation of pyruvate to form phosphoenolpyruvate and functions in regulating glycolysis
List of domain hits
Name
Accession
Description
Interval
E-value
Pyruvate_Kinase super family
cl39076 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of ...
42-330
1.60e-174
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low affinity T state. PK exists as several different isozymes, depending on organism and tissue type. In mammals, there are four PK isozymes: R, found in red blood cells, L, found in liver, M1, found in skeletal muscle, and M2, found in kidney, adipose tissue, and lung. PK forms a homotetramer, with each subunit containing three domains. The T state to R state transition of PK is more complex than in most allosteric enzymes, involving a concerted rotation of all 3 domains of each monomer in the homotetramer.
cd00288 :Pssm-ID: 453956 [Multi-domain]
Cd Length: 480
Bit Score: 493.37
E-value: 1.60e-174
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119598295 42 A R N T G I I CTIGPA SR SVE T LK EM IK S GMNVAR L NFSHG T HEYH AET I K NVR T A T E SFA sdpily R PVA V ALDTKGPEIRT 121
Cdd:cd00288 1 L R R T K I V CTIGPA TD SVE N LK KL IK A GMNVAR M NFSHG S HEYH QSR I D NVR E A A E KTG ------ G PVA I ALDTKGPEIRT 74
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119598295 122 GL I KG S gt AEVE LK K G ATLKI T L D N A y ME K CDENILWL DYKN IC K V V EV G SK I Y VDDGL I SL Q V KQ K GA D - F LV T EV E NG 200
Cdd:cd00288 75 GL F KG G -- KDIS LK A G DKFLV T T D P A - AK K GTKEKIYV DYKN LT K D V SP G NT I L VDDGL L SL K V LS K DD D k T LV C EV L NG 151
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119598295 201 G S LGS K KGVNLPG AA VDLPA V SEKD IQ DL K FGVEQ D VDM V FASF I RKASDV H E V R K VLGEKGK N IKII S KIEN H EGV RR q 280
Cdd:cd00288 152 G V LGS R KGVNLPG TD VDLPA L SEKD KA DL R FGVEQ G VDM I FASF V RKASDV L E I R E VLGEKGK D IKII A KIEN Q EGV NN - 230
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 119598295 281 FDEILEASDGIMVARGDLG I EIPAE K VFLAQKM M I GR CN R AGKPVI C ATQ 330
Cdd:cd00288 231 FDEILEASDGIMVARGDLG V EIPAE E VFLAQKM L I AK CN L AGKPVI T ATQ 280
Name
Accession
Description
Interval
E-value
Pyruvate_Kinase
cd00288 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of ...
42-330
1.60e-174
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low affinity T state. PK exists as several different isozymes, depending on organism and tissue type. In mammals, there are four PK isozymes: R, found in red blood cells, L, found in liver, M1, found in skeletal muscle, and M2, found in kidney, adipose tissue, and lung. PK forms a homotetramer, with each subunit containing three domains. The T state to R state transition of PK is more complex than in most allosteric enzymes, involving a concerted rotation of all 3 domains of each monomer in the homotetramer.
Pssm-ID: 238178 [Multi-domain]
Cd Length: 480
Bit Score: 493.37
E-value: 1.60e-174
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119598295 42 A R N T G I I CTIGPA SR SVE T LK EM IK S GMNVAR L NFSHG T HEYH AET I K NVR T A T E SFA sdpily R PVA V ALDTKGPEIRT 121
Cdd:cd00288 1 L R R T K I V CTIGPA TD SVE N LK KL IK A GMNVAR M NFSHG S HEYH QSR I D NVR E A A E KTG ------ G PVA I ALDTKGPEIRT 74
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119598295 122 GL I KG S gt AEVE LK K G ATLKI T L D N A y ME K CDENILWL DYKN IC K V V EV G SK I Y VDDGL I SL Q V KQ K GA D - F LV T EV E NG 200
Cdd:cd00288 75 GL F KG G -- KDIS LK A G DKFLV T T D P A - AK K GTKEKIYV DYKN LT K D V SP G NT I L VDDGL L SL K V LS K DD D k T LV C EV L NG 151
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119598295 201 G S LGS K KGVNLPG AA VDLPA V SEKD IQ DL K FGVEQ D VDM V FASF I RKASDV H E V R K VLGEKGK N IKII S KIEN H EGV RR q 280
Cdd:cd00288 152 G V LGS R KGVNLPG TD VDLPA L SEKD KA DL R FGVEQ G VDM I FASF V RKASDV L E I R E VLGEKGK D IKII A KIEN Q EGV NN - 230
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 119598295 281 FDEILEASDGIMVARGDLG I EIPAE K VFLAQKM M I GR CN R AGKPVI C ATQ 330
Cdd:cd00288 231 FDEILEASDGIMVARGDLG V EIPAE E VFLAQKM L I AK CN L AGKPVI T ATQ 280
PK
pfam00224 Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain ...
42-330
1.11e-173
Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain nested within a larger TIM barrel. The active site is found in a cleft between the two domains.
Pssm-ID: 395168 [Multi-domain]
Cd Length: 348
Bit Score: 486.11
E-value: 1.11e-173
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119598295 42 A R N T G I I CTIGPAS R SVE T L KEM I KS G M NVAR L NFSHG T HEYH AET I K NVR T A T E SFASD pilyrp VA V ALDTKGPEIRT 121
Cdd:pfam00224 1 L R R T K I V CTIGPAS N SVE N L EKL I EA G A NVAR M NFSHG S HEYH QSR I D NVR E A E E KTGGT ------ VA I ALDTKGPEIRT 74
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119598295 122 G LI K G s G TAEV ELK K G ATLKITL D NA Y MEK CD ENILWL DYKNI C K V V E VG SK I Y VDDGL I SL Q V KQ K GA D F - LV T EV E NG 200
Cdd:pfam00224 75 G NT K D - G KKDI ELK A G DEMIVST D AK Y KGA CD DEMIYV DYKNI V K D V S VG GT I L VDDGL L SL K V LS K DD D K t LV V EV L NG 153
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119598295 201 G SL GS K KGVNLPG AA VDLPA V SEKD IQ DL K FGV EQD VDM V FASF I RKASDV H E V R K VLGE K GKNI K II S KIEN H EGV RR q 280
Cdd:pfam00224 154 G VI GS R KGVNLPG TD VDLPA L SEKD KA DL R FGV KNG VDM I FASF V RKASDV L E I R E VLGE A GKNI Q II A KIEN Q EGV NN - 232
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 119598295 281 FDEILEA S DGIMVARGDLGIEIPAE K VFLAQKM M I GR CN R AGKPVI C ATQ 330
Cdd:pfam00224 233 FDEILEA T DGIMVARGDLGIEIPAE E VFLAQKM L I AK CN L AGKPVI T ATQ 282
pyruv_kin
TIGR01064 pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of ...
43-330
5.08e-165
pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of fructose-1,6-bisphosphate or similar phosphorylated sugars. [Energy metabolism, Glycolysis/gluconeogenesis]
Pssm-ID: 273424 [Multi-domain]
Cd Length: 472
Bit Score: 468.68
E-value: 5.08e-165
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119598295 43 R N T G I I CTIGPA SR S V E T LK EMIKS GMNVARLNFSHG T HE Y H AET I K NVR T A T E SFA sdpily RPVA VA LDTKGPEIRTG 122
Cdd:TIGR01064 1 R R T K I V CTIGPA TN S P E M LK KLLDA GMNVARLNFSHG S HE E H GKR I E NVR E A A E KLG ------ RPVA IL LDTKGPEIRTG 74
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119598295 123 L IKG S gta EV E LKKG ATLK IT L D NAYM E k C DE NILWL DYK NIC K V V EV G S KI Y VDDG L ISL Q V KQKGA D FLVT EV E NGG S 202
Cdd:TIGR01064 75 E IKG G --- EV K LKKG DKVI IT T D DIKG E - G DE EKVYV DYK GLT K D V VE G D KI L VDDG K ISL V V VSVEG D KVIC EV L NGG T 150
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119598295 203 L G SKKGVNLPGA A VDLPA V SEKD IQ DLKFGVEQ D VDMV F ASF I R K A S DV H EVR K VLGEKG - K NI KII S KIEN H EGV RR q F 281
Cdd:TIGR01064 151 L K SKKGVNLPGA D VDLPA L SEKD KK DLKFGVEQ G VDMV A ASF V R T A E DV L EVR E VLGEKG a K DV KII A KIEN Q EGV DN - I 229
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 119598295 282 DEI L EASDGIMVARGDLG I EIPAE K V FL AQK M MI GR CNRAGKPVI C ATQ 330
Cdd:TIGR01064 230 DEI A EASDGIMVARGDLG V EIPAE E V PI AQK K MI RK CNRAGKPVI T ATQ 278
PykF
COG0469 Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the ...
43-330
3.02e-149
Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the Pathway/BioSystem: Glycolysis
Pssm-ID: 440237 [Multi-domain]
Cd Length: 471
Bit Score: 428.68
E-value: 3.02e-149
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119598295 43 R N T G I IC T I GPAS R S V E T L KEM I KS GM N VARLNFSHG T HE Y H A E T I KNV R T A TE sfasdp I L Y RPVA VA LD TK GP E IRTG 122
Cdd:COG0469 3 R R T K I VA T L GPAS D S P E V L RKL I EA GM D VARLNFSHG D HE E H R E R I ELI R E A AK ------ E L G RPVA IL LD LQ GP K IRTG 76
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119598295 123 LI K GSG tae VELKKG A T LKI T L D N aym EKC D ENILWLD Y KNICKV V EV G SK I YV DDG L I S L Q V KQKGA D FL V T EV E NGG S 202
Cdd:COG0469 77 KF K EGP --- VELKKG D T FTL T T D D --- VEG D AERVSVT Y PELPED V KP G DR I LL DDG K I E L R V EEVEG D EV V C EV V NGG V 150
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119598295 203 L G S K KGVNLPG AAVD LPA VS EKD IQ DLKF GV E QD VD MVFA SF I R K A S DV H E V R KV L G E K G KNIK II S KIE NH E G V RR q F D 282
Cdd:COG0469 151 L S S R KGVNLPG VGLS LPA LT EKD RE DLKF AL E LG VD FIAL SF V R S A E DV L E A R EL L E E A G GRAP II A KIE KP E A V EN - L D 229
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 119598295 283 EI L EASDGIMVARGDLG I EIP A E K V F L A QK MM I GRCN RAGKPVI C ATQ 330
Cdd:COG0469 230 EI I EASDGIMVARGDLG V EIP L E E V P L I QK RI I RKAR RAGKPVI T ATQ 277
PRK05826
PRK05826 pyruvate kinase; Provisional
43-330
3.71e-130
pyruvate kinase; Provisional
Pssm-ID: 235619 [Multi-domain]
Cd Length: 465
Bit Score: 379.88
E-value: 3.71e-130
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119598295 43 R N T G I IC T I GPAS R S V E T L KEM I KS G M NV A RLNFSHG T HE Y H AETIKN VR TATES fasdpi L Y RPVA VA LD T KGP E IR T G 122
Cdd:PRK05826 4 R R T K I VA T L GPAS D S P E N L EKL I EA G V NV V RLNFSHG S HE E H GKRAAL VR EIAAK ------ L G RPVA IL LD L KGP K IR V G 77
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119598295 123 LI K GS gta EVE LK K G A tl K I TLD NAYM E KC D ENILWL DYK NIC K V V EV G SKIYV DDG LIS L Q V KQKGA D FLV TEV E NGG S 202
Cdd:PRK05826 78 KF K EG --- KIT LK T G D -- K F TLD TDQK E EG D KERVGV DYK GLP K D V KP G DILLL DDG KLQ L K V VEVDG D EVE TEV K NGG P 152
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119598295 203 L GSK KG V N L PG AAVD LPA VS EKD IQ D L KF GV EQ D VD MVFA SF I R K A S DV H E V R KV L G E K G - KNI KII S KIE NH E G V RR q F 281
Cdd:PRK05826 153 L SNN KG I N I PG GGLS LPA LT EKD KA D I KF AA EQ G VD YIAV SF V R S A E DV E E A R RL L R E A G c PHA KII A KIE RA E A V DN - I 231
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 119598295 282 DEI L EASDGIMVARGDLG I EIP A E K V FLA QK MM I GRCNR AGKPVI C ATQ 330
Cdd:PRK05826 232 DEI I EASDGIMVARGDLG V EIP D E E V PGL QK KI I RKARE AGKPVI T ATQ 280
Name
Accession
Description
Interval
E-value
Pyruvate_Kinase
cd00288 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of ...
42-330
1.60e-174
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low affinity T state. PK exists as several different isozymes, depending on organism and tissue type. In mammals, there are four PK isozymes: R, found in red blood cells, L, found in liver, M1, found in skeletal muscle, and M2, found in kidney, adipose tissue, and lung. PK forms a homotetramer, with each subunit containing three domains. The T state to R state transition of PK is more complex than in most allosteric enzymes, involving a concerted rotation of all 3 domains of each monomer in the homotetramer.
Pssm-ID: 238178 [Multi-domain]
Cd Length: 480
Bit Score: 493.37
E-value: 1.60e-174
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119598295 42 A R N T G I I CTIGPA SR SVE T LK EM IK S GMNVAR L NFSHG T HEYH AET I K NVR T A T E SFA sdpily R PVA V ALDTKGPEIRT 121
Cdd:cd00288 1 L R R T K I V CTIGPA TD SVE N LK KL IK A GMNVAR M NFSHG S HEYH QSR I D NVR E A A E KTG ------ G PVA I ALDTKGPEIRT 74
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119598295 122 GL I KG S gt AEVE LK K G ATLKI T L D N A y ME K CDENILWL DYKN IC K V V EV G SK I Y VDDGL I SL Q V KQ K GA D - F LV T EV E NG 200
Cdd:cd00288 75 GL F KG G -- KDIS LK A G DKFLV T T D P A - AK K GTKEKIYV DYKN LT K D V SP G NT I L VDDGL L SL K V LS K DD D k T LV C EV L NG 151
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119598295 201 G S LGS K KGVNLPG AA VDLPA V SEKD IQ DL K FGVEQ D VDM V FASF I RKASDV H E V R K VLGEKGK N IKII S KIEN H EGV RR q 280
Cdd:cd00288 152 G V LGS R KGVNLPG TD VDLPA L SEKD KA DL R FGVEQ G VDM I FASF V RKASDV L E I R E VLGEKGK D IKII A KIEN Q EGV NN - 230
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 119598295 281 FDEILEASDGIMVARGDLG I EIPAE K VFLAQKM M I GR CN R AGKPVI C ATQ 330
Cdd:cd00288 231 FDEILEASDGIMVARGDLG V EIPAE E VFLAQKM L I AK CN L AGKPVI T ATQ 280
PK
pfam00224 Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain ...
42-330
1.11e-173
Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain nested within a larger TIM barrel. The active site is found in a cleft between the two domains.
Pssm-ID: 395168 [Multi-domain]
Cd Length: 348
Bit Score: 486.11
E-value: 1.11e-173
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119598295 42 A R N T G I I CTIGPAS R SVE T L KEM I KS G M NVAR L NFSHG T HEYH AET I K NVR T A T E SFASD pilyrp VA V ALDTKGPEIRT 121
Cdd:pfam00224 1 L R R T K I V CTIGPAS N SVE N L EKL I EA G A NVAR M NFSHG S HEYH QSR I D NVR E A E E KTGGT ------ VA I ALDTKGPEIRT 74
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119598295 122 G LI K G s G TAEV ELK K G ATLKITL D NA Y MEK CD ENILWL DYKNI C K V V E VG SK I Y VDDGL I SL Q V KQ K GA D F - LV T EV E NG 200
Cdd:pfam00224 75 G NT K D - G KKDI ELK A G DEMIVST D AK Y KGA CD DEMIYV DYKNI V K D V S VG GT I L VDDGL L SL K V LS K DD D K t LV V EV L NG 153
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119598295 201 G SL GS K KGVNLPG AA VDLPA V SEKD IQ DL K FGV EQD VDM V FASF I RKASDV H E V R K VLGE K GKNI K II S KIEN H EGV RR q 280
Cdd:pfam00224 154 G VI GS R KGVNLPG TD VDLPA L SEKD KA DL R FGV KNG VDM I FASF V RKASDV L E I R E VLGE A GKNI Q II A KIEN Q EGV NN - 232
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 119598295 281 FDEILEA S DGIMVARGDLGIEIPAE K VFLAQKM M I GR CN R AGKPVI C ATQ 330
Cdd:pfam00224 233 FDEILEA T DGIMVARGDLGIEIPAE E VFLAQKM L I AK CN L AGKPVI T ATQ 282
pyruv_kin
TIGR01064 pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of ...
43-330
5.08e-165
pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of fructose-1,6-bisphosphate or similar phosphorylated sugars. [Energy metabolism, Glycolysis/gluconeogenesis]
Pssm-ID: 273424 [Multi-domain]
Cd Length: 472
Bit Score: 468.68
E-value: 5.08e-165
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119598295 43 R N T G I I CTIGPA SR S V E T LK EMIKS GMNVARLNFSHG T HE Y H AET I K NVR T A T E SFA sdpily RPVA VA LDTKGPEIRTG 122
Cdd:TIGR01064 1 R R T K I V CTIGPA TN S P E M LK KLLDA GMNVARLNFSHG S HE E H GKR I E NVR E A A E KLG ------ RPVA IL LDTKGPEIRTG 74
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119598295 123 L IKG S gta EV E LKKG ATLK IT L D NAYM E k C DE NILWL DYK NIC K V V EV G S KI Y VDDG L ISL Q V KQKGA D FLVT EV E NGG S 202
Cdd:TIGR01064 75 E IKG G --- EV K LKKG DKVI IT T D DIKG E - G DE EKVYV DYK GLT K D V VE G D KI L VDDG K ISL V V VSVEG D KVIC EV L NGG T 150
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119598295 203 L G SKKGVNLPGA A VDLPA V SEKD IQ DLKFGVEQ D VDMV F ASF I R K A S DV H EVR K VLGEKG - K NI KII S KIEN H EGV RR q F 281
Cdd:TIGR01064 151 L K SKKGVNLPGA D VDLPA L SEKD KK DLKFGVEQ G VDMV A ASF V R T A E DV L EVR E VLGEKG a K DV KII A KIEN Q EGV DN - I 229
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 119598295 282 DEI L EASDGIMVARGDLG I EIPAE K V FL AQK M MI GR CNRAGKPVI C ATQ 330
Cdd:TIGR01064 230 DEI A EASDGIMVARGDLG V EIPAE E V PI AQK K MI RK CNRAGKPVI T ATQ 278
PykF
COG0469 Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the ...
43-330
3.02e-149
Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the Pathway/BioSystem: Glycolysis
Pssm-ID: 440237 [Multi-domain]
Cd Length: 471
Bit Score: 428.68
E-value: 3.02e-149
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119598295 43 R N T G I IC T I GPAS R S V E T L KEM I KS GM N VARLNFSHG T HE Y H A E T I KNV R T A TE sfasdp I L Y RPVA VA LD TK GP E IRTG 122
Cdd:COG0469 3 R R T K I VA T L GPAS D S P E V L RKL I EA GM D VARLNFSHG D HE E H R E R I ELI R E A AK ------ E L G RPVA IL LD LQ GP K IRTG 76
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119598295 123 LI K GSG tae VELKKG A T LKI T L D N aym EKC D ENILWLD Y KNICKV V EV G SK I YV DDG L I S L Q V KQKGA D FL V T EV E NGG S 202
Cdd:COG0469 77 KF K EGP --- VELKKG D T FTL T T D D --- VEG D AERVSVT Y PELPED V KP G DR I LL DDG K I E L R V EEVEG D EV V C EV V NGG V 150
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119598295 203 L G S K KGVNLPG AAVD LPA VS EKD IQ DLKF GV E QD VD MVFA SF I R K A S DV H E V R KV L G E K G KNIK II S KIE NH E G V RR q F D 282
Cdd:COG0469 151 L S S R KGVNLPG VGLS LPA LT EKD RE DLKF AL E LG VD FIAL SF V R S A E DV L E A R EL L E E A G GRAP II A KIE KP E A V EN - L D 229
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 119598295 283 EI L EASDGIMVARGDLG I EIP A E K V F L A QK MM I GRCN RAGKPVI C ATQ 330
Cdd:COG0469 230 EI I EASDGIMVARGDLG V EIP L E E V P L I QK RI I RKAR RAGKPVI T ATQ 277
PRK05826
PRK05826 pyruvate kinase; Provisional
43-330
3.71e-130
pyruvate kinase; Provisional
Pssm-ID: 235619 [Multi-domain]
Cd Length: 465
Bit Score: 379.88
E-value: 3.71e-130
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119598295 43 R N T G I IC T I GPAS R S V E T L KEM I KS G M NV A RLNFSHG T HE Y H AETIKN VR TATES fasdpi L Y RPVA VA LD T KGP E IR T G 122
Cdd:PRK05826 4 R R T K I VA T L GPAS D S P E N L EKL I EA G V NV V RLNFSHG S HE E H GKRAAL VR EIAAK ------ L G RPVA IL LD L KGP K IR V G 77
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119598295 123 LI K GS gta EVE LK K G A tl K I TLD NAYM E KC D ENILWL DYK NIC K V V EV G SKIYV DDG LIS L Q V KQKGA D FLV TEV E NGG S 202
Cdd:PRK05826 78 KF K EG --- KIT LK T G D -- K F TLD TDQK E EG D KERVGV DYK GLP K D V KP G DILLL DDG KLQ L K V VEVDG D EVE TEV K NGG P 152
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119598295 203 L GSK KG V N L PG AAVD LPA VS EKD IQ D L KF GV EQ D VD MVFA SF I R K A S DV H E V R KV L G E K G - KNI KII S KIE NH E G V RR q F 281
Cdd:PRK05826 153 L SNN KG I N I PG GGLS LPA LT EKD KA D I KF AA EQ G VD YIAV SF V R S A E DV E E A R RL L R E A G c PHA KII A KIE RA E A V DN - I 231
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 119598295 282 DEI L EASDGIMVARGDLG I EIP A E K V FLA QK MM I GRCNR AGKPVI C ATQ 330
Cdd:PRK05826 232 DEI I EASDGIMVARGDLG V EIP D E E V PGL QK KI I RKARE AGKPVI T ATQ 280
PLN02461
PLN02461 Probable pyruvate kinase
45-330
3.81e-122
Probable pyruvate kinase
Pssm-ID: 215255 [Multi-domain]
Cd Length: 511
Bit Score: 361.22
E-value: 3.81e-122
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119598295 45 T G I I CT I GPASRSV ET L KEMIKS GMNVAR L NFSHG T HEYH A ET IK N V R T A T esf A SDP IL yrp V AV A LDTKGPEIRTG LI 124
Cdd:PLN02461 23 T K I V CT L GPASRSV PM L EKLLRA GMNVAR F NFSHG S HEYH Q ET LD N L R Q A M --- A NTG IL --- C AV M LDTKGPEIRTG FL 96
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119598295 125 K GSGT ae V E LK K G ATLK IT L D na Y ME K C DEN ILWLD YK NICKV V EV GS K I YVD DG L I S L Q V ---- KQK G adf L V T - EV EN 199
Cdd:PLN02461 97 K DGKP -- V Q LK Q G QEIT IT T D -- Y SI K G DEN MIAMS YK KLAVD V KP GS V I LCA DG T I T L T V lscd VEA G --- T V R c RC EN 169
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119598295 200 GGS LG SK K G VNLPG AA VDLP AVS EKD IQ D - L KF GV EQDV D MVFA SF I RK A SD VH EVRKVLGE KG K N I KI ISK I EN H EG VR 278
Cdd:PLN02461 170 SAM LG ER K N VNLPG VV VDLP TLT EKD KE D i L QW GV PNKI D FIAL SF V RK G SD LV EVRKVLGE HA K S I LL ISK V EN Q EG LD 249
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 119598295 279 r Q FD E IL EA SD GI MVARGDLG I EIP A EK V FLAQKMMI GR CN R AGKPV IC ATQ 330
Cdd:PLN02461 250 - N FD D IL AE SD AF MVARGDLG M EIP I EK I FLAQKMMI YK CN L AGKPV VT ATQ 300
PRK09206
PRK09206 pyruvate kinase PykF;
43-330
4.55e-120
pyruvate kinase PykF;
Pssm-ID: 181699 [Multi-domain]
Cd Length: 470
Bit Score: 354.36
E-value: 4.55e-120
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119598295 43 RN T G I I CTIGP ASR S V E T L KEMIKS GMNV A RLNFSHG THEY H AET IKN V R TATESFA sdpily RPV A VA LDTKGPEIRT g 122
Cdd:PRK09206 2 KK T K I V CTIGP KTE S E E M L TKLLDA GMNV M RLNFSHG DYAE H GQR IKN L R NVMSKTG ------ KKA A IL LDTKGPEIRT - 74
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119598295 123 l I K GS G TAE V E LK K G A T LKI T L D NAYME kc DENILWLD Y KNICKVVE VG SKIY VDDGLI SLQ V KQKGADFLVTE V E N G G S 202
Cdd:PRK09206 75 - M K LE G GND V S LK A G Q T FTF T T D KSVVG -- NKERVAVT Y EGFTADLS VG NTVL VDDGLI GME V TAITGNEVICK V L N N G D 151
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119598295 203 LG SK KGVNLPG AAVD LPA VS EKD I QDL K FG V EQ D VD M V F ASFIRK A SDV H E V R KV L GE - K G K NI K IISKIEN H EG V r RQ F 281
Cdd:PRK09206 152 LG EN KGVNLPG VSIA LPA LA EKD K QDL I FG C EQ G VD F V A ASFIRK R SDV L E I R EH L KA h G G E NI Q IISKIEN Q EG L - NN F 230
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 119598295 282 DEILEASDGIMVARGDLG I EIP A E K V FL AQKMMI GR CNRA G K P VI C ATQ 330
Cdd:PRK09206 231 DEILEASDGIMVARGDLG V EIP V E E V IF AQKMMI EK CNRA R K V VI T ATQ 279
PRK06354
PRK06354 pyruvate kinase; Provisional
30-330
1.97e-112
pyruvate kinase; Provisional
Pssm-ID: 235784 [Multi-domain]
Cd Length: 590
Bit Score: 338.82
E-value: 1.97e-112
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119598295 30 M CRL D idsppi TA R N T G I IC TIGPAS R S V E T L KEM I KS G MNV ARLNFSHG T HE Y H AET IKN V R T A TE sfasdp I L YRP V A 109
Cdd:PRK06354 1 M SLR D ------ LM R R T K I VA TIGPAS E S P E K L RQL I EA G ATT ARLNFSHG D HE E H GAR IKN I R E A SK ------ K L GKT V G 68
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119598295 110 VAL D TK GP E IR T G LIKGSG tae V ELK K G ATLKI T LDNA yme KCDENILWLD Y KNICKV V E VGS K I YV DDGLI S L Q V KQ -- 187
Cdd:PRK06354 69 ILQ D LQ GP K IR L G RFEDGP --- I ELK T G DEFIL T SREV --- LGTQEKFSVT Y DGLADE V P VGS R I LL DDGLI E L E V EE vd 142
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119598295 188 K GADF L VTE V EN GG S L GS KKGVN L PG AAVD LPA VS EKD IQ DL K FG V EQ D VD MVFA SF I R KA SDV H E V R KVLG E K - GK N I K 266
Cdd:PRK06354 143 K ADGE L HCK V LV GG V L SN KKGVN F PG VSLS LPA IT EKD RE DL I FG L EQ G VD WIAL SF V R NP SDV L E I R ELIE E H n GK H I P 222
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 119598295 267 II S KIE NH E GV r RQF D E ILE AS DG I MVARGDLG I EIPAE K V F L A QK MM I GRC NR A GKPVI C ATQ 330
Cdd:PRK06354 223 II A KIE KQ E AI - DNI D A ILE LC DG L MVARGDLG V EIPAE E V P L L QK RL I KKA NR L GKPVI T ATQ 285
PTZ00300
PTZ00300 pyruvate kinase; Provisional
69-330
4.91e-109
pyruvate kinase; Provisional
Pssm-ID: 140321 [Multi-domain]
Cd Length: 454
Bit Score: 325.85
E-value: 4.91e-109
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119598295 69 M N VAR L NFSHG T HEYH AE TI K NVR T A TESFASD pilyrp V A V ALDTKGPEIRTGL IK G SGTA eve LKK GAT LKI T L D N A Y 148
Cdd:PTZ00300 1 M S VAR M NFSHG S HEYH QT TI N NVR Q A AAELGVN ------ I A I ALDTKGPEIRTGL FV G GEAV --- MER GAT CYV T T D P A F 71
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119598295 149 ME K CDENILWL DY K N IC KVV EV G SK IY V DDG LIS L Q V KQKGADF - L VTE V E N GGSLGSKK GVNLPG AA VDLPAVS E KD IQ 227
Cdd:PTZ00300 72 AD K GTKDKFYI DY Q N LS KVV RP G GY IY I DDG ILI L H V QSHEDEQ t L KCT V T N AHTISDRR GVNLPG CD VDLPAVS A KD CA 151
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119598295 228 DL K FGVEQ D VDM V FASFIR K A SD V H EVRK V LG E KG KN I K II S KIENH E GV r RQF D E I L E A SDGIMVARGDLG I EIPAEKV 307
Cdd:PTZ00300 152 DL Q FGVEQ G VDM I FASFIR S A EQ V G EVRK A LG A KG GD I M II C KIENH Q GV - QNI D S I I E E SDGIMVARGDLG V EIPAEKV 230
250 260
....*....|....*....|...
gi 119598295 308 FL AQK MM I GR CN R AGKPVICATQ 330
Cdd:PTZ00300 231 VV AQK IL I SK CN V AGKPVICATQ 253
PTZ00066
PTZ00066 pyruvate kinase; Provisional
8-330
1.75e-108
pyruvate kinase; Provisional
Pssm-ID: 173361 [Multi-domain]
Cd Length: 513
Bit Score: 326.33
E-value: 1.75e-108
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119598295 8 A G T AFIQTQQ L HA A m ADTF L EHMCR l D I DSPPITARN T G I I CT I GPA SRS VETL KEM I KS GMN VA R L NFSHG T HE Y H AE T 87
Cdd:PTZ00066 5 A S T SSVMGCS L GK A - TNIS L DKILE - P I SDNDLRQKK T H I V CT M GPA CKN VETL VKL I DA GMN IC R F NFSHG D HE S H KK T 82
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119598295 88 IK NVR T A TES fasdpily RP --- VAVA LDTKGPEIRTG LI K GS gt AEVE LK K G A TLKIT L D na Y MEKC DE NILWLD YK NI 164
Cdd:PTZ00066 83 LN NVR E A AKA -------- RP nan LGIL LDTKGPEIRTG FL K NH -- KPIT LK E G Q TLKIT T D -- Y TFLG DE TCISCS YK KL 150
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119598295 165 CKV V E VG SK I YVD DG LI S LQ V KQKGA D FLV T E V E N GGSL G SK K GV NLPG AA V D LP AVS EKD IQ D - L K F GVEQDV D MVFA S 243
Cdd:PTZ00066 151 PQS V K VG NI I LIA DG SL S CK V LEVHD D YII T K V L N NATI G ER K NM NLPG VK V E LP VIG EKD KN D i L N F AIPMGC D FIAL S 230
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119598295 244 F IRK A S DV HEV R KV LGE K G KN IKII S KIEN H EG VR r Q FDEIL EA SDGIMVARGDLG I EIP A EKVFLAQKMMI GR CN R AGK 323
Cdd:PTZ00066 231 F VQS A D DV RLC R QL LGE R G RH IKII P KIEN I EG LI - N FDEIL AE SDGIMVARGDLG M EIP P EKVFLAQKMMI SK CN V AGK 309
....*..
gi 119598295 324 PVI C ATQ 330
Cdd:PTZ00066 310 PVI T ATQ 316
PRK06247
PRK06247 pyruvate kinase; Provisional
42-330
6.94e-93
pyruvate kinase; Provisional
Pssm-ID: 180487 [Multi-domain]
Cd Length: 476
Bit Score: 284.90
E-value: 6.94e-93
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119598295 42 A R NTG I IC T I GPAS R S VETLKEMIKS G MN V A RLNFSHG T H EY H A E TI K NV R TATES fasdpi LY RP VAVAL D TK GP EI R T 121
Cdd:PRK06247 4 N R RVK I LA T L GPAS S S EDMIRKLVEA G AD V F RLNFSHG D H DD H R E LY K RI R EVEDE ------ TG RP IGILA D LQ GP KL R L 77
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119598295 122 G LIKGS gta E V E L KK G A T LKITL D N A yme KC D ENILW L DYKN I CKVVEV G SKIY VDDG LIS L Q V KQKGA D FL V TE V EN GG 201
Cdd:PRK06247 78 G RFADG --- K V Q L AN G Q T FRLDV D D A --- PG D HDRVS L PHPE I AAALKP G DRLL VDDG KVR L V V EACDG D DV V CR V VE GG 151
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119598295 202 SLGSK KGV N LPG AAVDLP A VS EKD IQ DL K F GV E QD VD M V FA SF IRKAS DV H EVRK VL G EK gkn IKIIS KIE NHEGVR R q F 281
Cdd:PRK06247 152 PVSDR KGV S LPG TVLSVS A LT EKD RA DL E F AL E LG VD W V AL SF VQRPE DV E EVRK II G GR --- VPVMA KIE KPQAID R - L 227
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 119598295 282 DE I L EASD G IMVARGDLG I E I P A E K V F L A QK MM I GRCN RAGKPV IC ATQ 330
Cdd:PRK06247 228 EA I V EASD A IMVARGDLG V E V P L E Q V P L I QK RI I RAAR RAGKPV VV ATQ 276
PRK06739
PRK06739 pyruvate kinase; Validated
48-341
1.78e-76
pyruvate kinase; Validated
Pssm-ID: 180676 [Multi-domain]
Cd Length: 352
Bit Score: 239.08
E-value: 1.78e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119598295 48 ICTIGPAS RSV ETL KEM I KS GM NVA RLN F SHGTHE Y H AET I KN V RTATE S fasdpilyrp VAVAL D TK GP E IR T G L IKG S 127
Cdd:PRK06739 6 ICTIGPAS NNK ETL AQL I NN GM KIV RLN L SHGTHE S H KDI I RL V KSLDD S ---------- IKILG D VQ GP K IR L G E IKG E 75
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119598295 128 gta EVE L KK G ATLKITLDNAYMEKCDENI lwl DY KN I CKV V E VGS K I YVD DG LIS L Q V KQKGA D FLV T E V EN GG SLG S K K 207
Cdd:PRK06739 76 --- QIT L QA G DSFILHTQPVTGSSTEASV --- DY EG I AND V K VGS R I LMN DG EVE L I V EKVST D KIE T K V KT GG NIS S H K 149
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119598295 208 GVNLPGA A V D LPA VS EKD IQ D LK F GV E Q DVD MVFA SF I RK A S DVH E V R KVLGEKGKNI - KI I S KIE NH E GV r RQ F DE I LE 286
Cdd:PRK06739 150 GVNLPGA I V R LPA IT EKD KK D IQ F LL E E DVD FIAC SF V RK P S HIK E I R DFIQQYKETS p NL I A KIE TM E AI - EN F QD I CK 228
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 119598295 287 AS DGIM V ARGDLG I E I P AEKVF L A QKMMI GR CNR AGKP VI C ATQ AYAGEH D QEA P 341
Cdd:PRK06739 229 EA DGIM I ARGDLG V E L P YQFIP L L QKMMI QE CNR TNTY VI T ATQ MLQSMV D HSI P 283
PLN02623
PLN02623 pyruvate kinase
37-329
4.32e-69
pyruvate kinase
Pssm-ID: 215334 [Multi-domain]
Cd Length: 581
Bit Score: 226.35
E-value: 4.32e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119598295 37 S P P ITA R N T G I I CTIGP ASRSV E TLKEMIKS GMNVARLN F SHG T H EY H AET I KN V RTATESFASDP I lyrpv A VA LDTKG 116
Cdd:PLN02623 104 S K P SVR R K T K I V CTIGP STNTR E MIWKLAEA GMNVARLN M SHG D H AS H QKV I DL V KEYNAQSKDNV I ----- A IM LDTKG 178
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119598295 117 PE I R T G LIK gsgt AEVE L KK G ATLKI T LDNAY - M E K C deni LWLD Y KNICKV VEVG SKIY VD D G LI SL Q VK Q K GA D FLVT 195
Cdd:PLN02623 179 PE V R S G DLP ---- QPIM L EE G QEFTF T IKRGV s T E D C ---- VSVN Y DDFVND VEVG DMLL VD G G MM SL A VK S K TS D SVKC 250
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119598295 196 EV EN GG S L G S KKGV N LP G AAVD LP AVS EKD IQ D L KFGVE QD VD MVFA SF IRK A SD VHE VRKV L GEKGKN I KI I S KIE NHE 275
Cdd:PLN02623 251 EV VD GG E L K S RRHL N VR G KSAT LP SIT EKD WE D I KFGVE NK VD FYAV SF VKD A QV VHE LKDY L KSCNAD I HV I V KIE SAD 330
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 119598295 276 GV r RQFDE I LE ASDG I MVARGDLG I E I P A E K V F L A Q KMM I G RC NRA GKPVI C AT 329
Cdd:PLN02623 331 SI - PNLHS I IT ASDG A MVARGDLG A E L P I E E V P L L Q EEI I R RC RSM GKPVI V AT 383
PLN02765
PLN02765 pyruvate kinase
45-326
6.20e-65
pyruvate kinase
Pssm-ID: 215409 [Multi-domain]
Cd Length: 526
Bit Score: 214.15
E-value: 6.20e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119598295 45 T G I IC T I GP A SRSVE TLKEMI K S GM N VAR LN FS H G TH EYH A ET IK N VRT A TES fasdpi LYRPV AV A LDT K GPE IR tgl I 124
Cdd:PLN02765 30 T K I VG T L GP K SRSVE VIEACL K A GM S VAR FD FS W G DA EYH Q ET LE N LKI A VKN ------ TKKLC AV M LDT V GPE LQ --- V 100
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119598295 125 KGSGTAEVE LK K G A T LKI T L D N ay MEKCDENI L WLDYKNIC K V V EV G SK I Y V DDG L IS -------- L Q V KQKGA D FL V TE 196
Cdd:PLN02765 101 INKTEKPIS LK A G N T VTL T P D Q -- SKEASSEV L PINFPGLA K A V KP G DT I F V GQY L FT gsettsvw L E V DEVKG D DV V CT 178
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119598295 197 V E N GGS L - GS KKGVNLPGAAV DLP AV SEKD IQDLK - F GV EQDV D MVFA S FI R K A S DV H E V R KV L GEK G - KNIK I IS KIEN 273
Cdd:PLN02765 179 V K N SAT L a GS LFTLHVSQVRI DLP TL SEKD KEVIS t W GV PNKI D FLSL S YT R H A E DV R E A R EF L SSL G l SQTQ I FA KIEN 258
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 119598295 274 H EG VR r Q FDEIL EAS DGI MVA RG D LGI EI P A EKVFL A QK MMIGR CN R AGKP VI 326
Cdd:PLN02765 259 V EG LT - H FDEIL QEA DGI ILS RG N LGI DL P P EKVFL F QK AALYK CN M AGKP AV 310
PLN02762
PLN02762 pyruvate kinase complex alpha subunit
42-330
6.49e-51
pyruvate kinase complex alpha subunit
Pssm-ID: 215407 [Multi-domain]
Cd Length: 509
Bit Score: 176.47
E-value: 6.49e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119598295 42 A R N T GII CTIGPA SRSV E T L KEMIKS GMNVARLN FS HGT H E Y H AET I KN VR -- TATES FA sdpilyrp VAV AL DT K G P EI 119
Cdd:PLN02762 24 T R R T KLV CTIGPA CCGF E Q L EALAMG GMNVARLN MC HGT R E W H RDV I RR VR rl NEEKG FA -------- VAV MM DT E G S EI 95
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119598295 120 RT G LIK G SGT A EV E lk K G ATLKI T L d NAYMEKCD E NILWLD Y KNICKV V E VG SKIY VD D G LISLQ V KQ K - G A D FLVTEVE 198
Cdd:PLN02762 96 HM G DLG G ASS A KA E -- D G EEWTF T V - RKFDGSRP E FTIQVN Y DGFAED V K VG DELV VD G G MVRFE V IE K i G P D VKCKCTD 172
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119598295 199 N G ------------- GSL GSKKGVN lpgaavd LP AV S E KD IQ D LK FG VEQD VD MVFA SF IRK A SDVHEVRKVLGEKGKN - 264
Cdd:PLN02762 173 P G lllpranltfwrd GSL VRERNAM ------- LP TI S S KD WL D ID FG ISEG VD FIAV SF VKS A EVIKHLKSYIAARSRD s 245
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 119598295 265 - I KI I S KIE NHEGVRR q FD EI LE ASDG I MVARGDLG IE IP A E K V FLA Q KMMIGR C NRAG KPVI C A T Q 330
Cdd:PLN02762 246 d I GV I A KIE SLDSLKN - LE EI IR ASDG A MVARGDLG AQ IP L E Q V PSV Q EKIVRL C RQLN KPVI V A S Q 311
PRK08187
PRK08187 pyruvate kinase; Validated
38-330
1.16e-39
pyruvate kinase; Validated
Pssm-ID: 236178
Cd Length: 493
Bit Score: 145.93
E-value: 1.16e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119598295 38 P PIT AR N T G I IC T I - GP A SRSVETLKEMIKS GM NV AR L N FS H GTHEYHAET I KNV R T A TESFA sdpily R PVAVAL D TK G 116
Cdd:PRK08187 128 P RPA AR R T R I MV T L p SE A ADDPDFVLRLAER GM DC AR I N CA H DDPAAWQAM I GHL R Q A ERATG ------ R RCKILM D LA G 201
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119598295 117 P E IRTG LIK G s GTAEVE L KK G AT L KITLDNA y MEKC DE NILWLD ykni C KV ------ VE VG SKIYV DDG LISLQ V KQK G A 190
Cdd:PRK08187 202 P K IRTG AVA G - PLGKTR L YT G DR L ALVAQGP - PRRI DE EHFQVT ---- C TL peilar LA VG ARVWI DDG KLGAR V ERV G P 275
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119598295 191 DFLVT EV ---- EN G GS L GSK KG V N L P GA A V DLPA VS EKD IQ DL K F GVEQ d V D M V FA SF IRKAS DV HEVRKV L GEKGKN -- 264
Cdd:PRK08187 276 GGALL EV thar PK G LK L KPE KG L N F P DT A L DLPA LT EKD RA DL D F VARH - A D L V GY SF VQSPG DV EALQAA L AARRPD dw 354
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 119598295 265 -- IKIIS KIE NHEG V RRQFDE I LE A SD ---- G I M V ARGDL GI EI PA E KVFLA Q KMMIGR C NR A GK PVI C ATQ 330
Cdd:PRK08187 355 rk LGLVL KIE TPRA V ANLPEL I VQ A AG rqpf G V M I ARGDL AV EI GF E RLAEM Q EEILWL C EA A HV PVI W ATQ 426
PRK14725
PRK14725 pyruvate kinase; Provisional
38-330
8.61e-29
pyruvate kinase; Provisional
Pssm-ID: 237804
Cd Length: 608
Bit Score: 116.97
E-value: 8.61e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119598295 38 PP ITA R N T G I IC T I - GP A SRSVETLKEMIKS GM NV AR L N FS H GTH E YHAET I K NVRTA T E S fasdpi L Y R PVAV A L D TK G 116
Cdd:PRK14725 134 PP PSG R P T R I MV T L p TE A ADDPDLVRRLLAA GM DI AR I N CA H DDP E AWRAM I A NVRTA E E E ------ L G R RCRI A M D LA G 207
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119598295 117 P EI RTG --------------------------- LIKG S GTAEVE ----------------- L KK G AT L ---------- K I 142
Cdd:PRK14725 208 P KL RTG piapgprviklrptrdalgrvltparl WLTA S ESPPPS pppgpvglpvdpewlar L EP G DE L rftdargkkr K L 287
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119598295 143 T L ------------- DN AY ME kc DENI L W L DYKNICK V ------------------------------------------ 167
Cdd:PRK14725 288 T V tevddegvlaegs QT AY LA -- NGTL L R L GRHDSTR V gglppveqklrlkvgdrlvltrddapgdpaqgdapparisct 365
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119598295 168 ------- VE VG SKIYV DDG L I SLQ V KQKG AD FLVTEVENGGSL GSK ---- KG V NLP GAAVD LPA VSE KD IQ DL K F GVEQ d 236
Cdd:PRK14725 366 lpeafra AR VG ERVWF DDG K I GAV V VKVE AD EVELRITHARPG GSK lkag KG I NLP DSHLP LPA LTD KD LE DL A F VAKH - 444
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119598295 237 V D M V FA SF I R KAS DV HEVRKV L GE - KGKNIKIIS KIE NHEGVRRQFDEI LEA ---- SD G I M V ARGDL GI E IPA E KVFLA Q 311
Cdd:PRK14725 445 A D I V AL SF V R SPE DV RLLLDA L EK l GADDLGVVL KIE TRRAFENLPRIL LEA mrhp RF G V M I ARGDL AV E VGF E RLAEV Q 524
410
....*....|....*....
gi 119598295 312 KMMIGR C NR A GK PVI C ATQ 330
Cdd:PRK14725 525 EEILWL C EA A HV PVI W ATQ 543
Blast search parameters
Data Source:
Precalculated data, version = cdd.v.3.21
Preset Options: Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
