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Conserved domains on  [gi|119604667|gb|EAW84261|]
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zinc finger protein 625, isoform CRA_a [Homo sapiens]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11472214)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
104-284 3.79e-08

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 54.32  E-value: 3.79e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119604667 104 KSFISRSSIRRHRIMHSGDG-PYKCNFCGKALMCLSLYLIHKRT--HTGE--KPYEC--KQCGKAFSHSGSLRIHERTHT 176
Cdd:COG5048  268 ASSQSSSPNESDSSSEKGFSlPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHT 347

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119604667 177 GEKPYEC--SECGKAFHSS------TCLHAHKITHTgEKPYEC--KQCGKAFVSFNSVRYHERTHTGEKPYECK--QCGK 244
Cdd:COG5048  348 SISPAKEklLNSSSKFSPLlnneppQSLQQYKDLKN-DKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSK 426

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 119604667 245 AFRSASHLRTHGRTHTGEKPYECKQCGKAFGCASSVKIHE 284
Cdd:COG5048  427 SFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
104-284 3.79e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 54.32  E-value: 3.79e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119604667 104 KSFISRSSIRRHRIMHSGDG-PYKCNFCGKALMCLSLYLIHKRT--HTGE--KPYEC--KQCGKAFSHSGSLRIHERTHT 176
Cdd:COG5048  268 ASSQSSSPNESDSSSEKGFSlPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHT 347

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119604667 177 GEKPYEC--SECGKAFHSS------TCLHAHKITHTgEKPYEC--KQCGKAFVSFNSVRYHERTHTGEKPYECK--QCGK 244
Cdd:COG5048  348 SISPAKEklLNSSSKFSPLlnneppQSLQQYKDLKN-DKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSK 426

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 119604667 245 AFRSASHLRTHGRTHTGEKPYECKQCGKAFGCASSVKIHE 284
Cdd:COG5048  427 SFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
zf-H2C2_2 pfam13465
Zinc-finger double domain;
167-190 1.09e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.09e-03
                          10        20
                  ....*....|....*....|....
gi 119604667  167 SLRIHERTHTGEKPYECSECGKAF 190
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
104-284 3.79e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 54.32  E-value: 3.79e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119604667 104 KSFISRSSIRRHRIMHSGDG-PYKCNFCGKALMCLSLYLIHKRT--HTGE--KPYEC--KQCGKAFSHSGSLRIHERTHT 176
Cdd:COG5048  268 ASSQSSSPNESDSSSEKGFSlPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHT 347

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119604667 177 GEKPYEC--SECGKAFHSS------TCLHAHKITHTgEKPYEC--KQCGKAFVSFNSVRYHERTHTGEKPYECK--QCGK 244
Cdd:COG5048  348 SISPAKEklLNSSSKFSPLlnneppQSLQQYKDLKN-DKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSK 426

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 119604667 245 AFRSASHLRTHGRTHTGEKPYECKQCGKAFGCASSVKIHE 284
Cdd:COG5048  427 SFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
66-228 1.95e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 52.01  E-value: 1.95e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119604667  66 QKPYKCTYCKKAFSDLPYFRTH--EWAHTG--GKPYDCEE--CGKSFISRSSIRRHRIMHSGDGPYKCNFC-------GK 132
Cdd:COG5048  287 SLPIKSKQCNISFSRSSPLTRHlrSVNHSGesLKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLnssskfsPL 366

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119604667 133 ALMCLSLYLIHKRTHTGEKPYEC--KQCGKAFSHSGSLRIHERTHTGEKPYEC--SECGKAFHSSTCLHAHKITHTGEKP 208
Cdd:COG5048  367 LNNEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCknPPCSKSFNRHYNLIPHKKIHTNHAP 446

                        170       180
                 ....*....|....*....|
gi 119604667 209 YECKQCGKAFVSFNSVRYHE 228
Cdd:COG5048  447 LLCSILKSFRRDLDLSNHGK 466
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 149-232 2.42e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 45.48  E-value: 2.42e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119604667 149 GEKPYECK--QCGKAFSHSGSLRIHeRTHtgekpyecSECGKAFHSSTCLHAHKITHTGEKPYECKQCGKAFVSFNSVRY 226
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYH-MLH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ....*.
gi 119604667 227 HeRTHT 232
Cdd:COG5189  417 H-RKHS 421
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
124-195 3.79e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.99  E-value: 3.79e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 119604667 124 PYKCNFCGKALMCLSLYLIHKRTHTGEKPYEC--KQCGKAFSHSGSLRIHERTHTGEKPYECSECGKAFHSSTC 195
Cdd:COG5048   33 PDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKAS 106
zf-H2C2_2 pfam13465
Zinc-finger double domain;
167-190 1.09e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.09e-03
                          10        20
                  ....*....|....*....|....
gi 119604667  167 SLRIHERTHTGEKPYECSECGKAF 190
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
223-248 1.13e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.13e-03
                          10        20
                  ....*....|....*....|....*.
gi 119604667  223 SVRYHERTHTGEKPYECKQCGKAFRS 248
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
143-164 1.48e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 1.48e-03
                          10        20
                  ....*....|....*....|..
gi 119604667  143 HKRTHTGEKPYECKQCGKAFSH 164
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 150-260 1.56e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 39.70  E-value: 1.56e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119604667 150 EKPYECKQCGKAFSHSGSLRIHERTH----TGEKPYECS--ECGKAFHSSTCL-----HAHKITHTGEKPYECKQCGkaF 218
Cdd:COG5189  315 KLPCTNSSSNGKLAHGGERNIDTPSRmlkvKDGKPYKCPveGCNKKYKNQNGLkyhmlHGHQNQKLHENPSPEKMNI--F 392

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 119604667 219 VSFNsvryherthtgeKPYECKQCGKAFRSASHLRTHgRTHT 260
Cdd:COG5189  393 SAKD------------KPYRCEVCDKRYKNLNGLKYH-RKHS 421
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
151-223 2.39e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 39.29  E-value: 2.39e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 119604667 151 KPYECKQCGKAFSHSGSLRIHERTHTGEKPYECS--ECGKAFHSSTCLHAHKITHTGEKPYECKQCGKAFVSFNS 223
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKAS 106
zf-H2C2_2 pfam13465
Zinc-finger double domain;
251-274 4.32e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 4.32e-03
                          10        20
                  ....*....|....*....|....
gi 119604667  251 HLRTHGRTHTGEKPYECKQCGKAF 274
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
199-220 7.50e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.50  E-value: 7.50e-03
                          10        20
                  ....*....|....*....|..
gi 119604667  199 HKITHTGEKPYECKQCGKAFVS 220
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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